{
    "QDMcmF8V": {
        "id": "QDMcmF8V",
        "title": "A 1H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats",
        "abstract": "To investigate and compare the metabonomic profiles of three stress-based models of depression, the effects of acute and chronic stress on the production of systemic endogenous metabolites were investigated. Such metabonomic analysis may provide researchers a new way of selecting appropriate animal models for the study of depression and antidepressants. Rats were subjected to one of three stress-based models: CUMS, FST-1d, or FST-14d. Endogenous metabolites excreted in plasma were analyzed using NMR in conjunction with multivariate and statistical techniques. The metabonomic study indicated that the concentration of different plasma metabolites could be used to differentiate among depression models: TMA, aspartic acid, glutamate, AcAc, NAc, alanine, lactate, Leu/Ile, lipids increased and proline, β-HB, valine decreased in the CUMS model; TMA decreased in the FST-1d model; α-glucose, β-glucose, β-HB, valine and lipids increased in the FST-14d model. The results suggested that metabonomics is a potentially appropriate method for evaluating depression models. According to the metabonomics study, CUMS model was more suitable and sensitive than the acute FST-1d model and predictable FST-14d model. The CUMS model was more appropriate for investigating both the efficacy of antidepressants and their mechanisms of action, while the FST-14d model should only be used for evaluating the efficacy of treatment.",
        "keywords": [
            "AcAc",
            "BCAAs",
            "β-HB",
            "CPMG",
            "CUMS",
            "D",
            "O",
            "FST",
            "Leu/Ile",
            "NAc",
            "NIH",
            "NMR",
            "PCA",
            "PLS-DA",
            "TCA",
            "TMA",
            "Metabonomics",
            "Chronic unpredicted mild stress",
            "Forced swim test",
            "Nuclear magnetic resonance",
            "Depression"
        ],
        "authors": [
            {
                "name": "Biyun Shi",
                "org": "College of Chemistry and Chemical Engineering of Shanxi University, Taiyuan 030006, PR China;Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, PR China"
            },
            {
                "name": "Junsheng Tian",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering of Ministry Education of Shanxi University, Taiyuan 030006, PR China;Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, PR China"
            },
            {
                "name": "Huan Xiang",
                "org": "Physical Education Department of Shanxi University, Taiyuan, 030006, PR China"
            },
            {
                "name": "Xiaoqing Guo",
                "org": "College of Chemistry and Chemical Engineering of Shanxi University, Taiyuan 030006, PR China;Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, PR China"
            },
            {
                "name": "Lizeng Zhang",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering of Ministry Education of Shanxi University, Taiyuan 030006, PR China;Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, PR China"
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China"
            },
            {
                "name": "Xuemei Qin",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering of Ministry Education of Shanxi University, Taiyuan 030006, PR China;Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, PR China"
            }
        ],
        "venue": "Behavioural Brain Research",
        "year": 2013
    },
    "o731Ylil": {
        "id": "o731Ylil",
        "title": "Analysis of the mechanisms underlying the vasorelaxant action of coptisine in rat aortic rings.",
        "abstract": "The aim of the present study was to evaluate the vasorelaxant effects of coptisine and its possible mechanisms in isolated rat aortic rings. Coptisine was evaluated on isolated rat aortic rings precontracted with norepinephrine (NE) and KCl. The mechanisms were evaluated in the presence or absence of specific pharmacological inhibitors. Coptisine (1 similar to 200 mu M) relaxed NE (1 mu M) or KCl (60 mM) induced sustained contraction with pEC(50) values of 4.49 +/- 0.48 and 4.85 +/- 0.57 in a concentration dependent manner. Pretreatment with coptisine (10, 50 or 100 mu M) also inhibited concentration-response curves to NE and KCl. The vasorelaxant effect of coptisine was attenuated significantly by endothelium removal, and incubation with N omega-nitro-L-arginine methyl ester (L-NAME, 100 mu M), methylene blue (10 mu M) and indomethacin (5 mu M) partially reduced the vasorelaxant effect of coptisine. In endothelium-denuded rings, the vasorelaxant effect of coptisine was reduced significantly by 4-aminopyridine (4-AP, 100 mu M), but not glibenclamide (10 mu M) ortetraethylammonium (TEA, 5 mM). Coptisine also reduced NE-induced transient contraction in Ca2+-free solution, and inhibited contraction induced by increasing external calcium in Ca2+-free medium plus 60mM KCl. It was concluded that coptisine induced both endothelium-dependent and -independent relaxation in rat aortic rings. The NO-cGMP mediated pathway may be involved in the endothelium-dependent relaxation and in the activation of voltage-dependent K+ channels, contributing in part to the endothelium-independent relaxation bycoptisine. Coptisine also blocks extracellular Ca2+ influx by interacting with both voltage- and receptor-operated Ca2+ channels.",
        "keywords": [
            "Coptisine",
            "Vasorelaxation",
            "Aorta",
            "Endothelium",
            "Nitric Oxide"
        ],
        "authors": [
            {
                "name": "Li-Li Gong",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China"
            },
            {
                "name": "Yang Lv",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "AMERICAN JOURNAL OF CHINESE MEDICINE",
        "year": 2012
    },
    "YRDwwNV5": {
        "id": "YRDwwNV5",
        "title": "Correlation between Effect of Icariin on Learning and Memory and Level of Estradiol in Serum in Senescence Accelerated Mouse Prone/8",
        "abstract": "Objective:To probe the correlation between the effect of icariin on learning and memory and the level of estadiol(E_2) in serum in senescence accelerated mouse prone/8(SAMP8).Methods:10 six-mon-old senescence accelerated mouse resistance 1(SAMR1) and 40 the same age SAMP8 were selected.SAMP8 were divided randomly into 4 groups(model,75 and 150 mg·kg~(-1) icariin ig,and 0.2 mg·kg~(-1) diethylstilbestrol ig).Then,the effects of icariin administration by oral gavage for 3 months on learning and memory deficits in SAMP8 and SAMR1 were investigated by the Morris water maze test;the level of E_2 in serum in SAMP8 and SAMR1 was determined by radioimmunoassay kit.The mice were sacrificed after ethology test,and the uterus coefficient was calculated. Results: The administration of icariin orally could enhance the learning and memory ability of SAMP8 in Morris water maze test;increase the level of E_2 in serum in SAMP8;create non-significant difference in the uterus coefficient of SAMP8.There was a significant negative correlation between the latency in Morris water maze test and the level of E_2 in serum in SAMP8 analyzed by Pearson correlation coefficient.Conclusions: Icariin could improve the cognitive impairments of SAMP8,and its mechanism may be related to the increase in the level of estrogen in serum in SAMP8.",
        "keywords": [
            "icariin",
            "learning and memory",
            "senescence accelerated mouse prone/8",
            "estradiol"
        ],
        "authors": [
            {
                "name": "ZHOU Wei-qin",
                "org": "Institute of Medicinal Plant Development,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing ,China"
            },
            {
                "name": "DENG Jing-yue",
                "org": "Institute of Medicinal Plant Development,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing ,China"
            },
            {
                "name": "BI Ming-gang",
                "org": "Institute of Medicinal Plant Development,Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing ,China;Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2009
    },
    "YgYV6410": {
        "id": "YgYV6410",
        "title": "Cloning and expression of human lectin-like oxidized low density lipoprotein receptor-1 inRequirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoproteinIncreased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbitsBiosynthesis and post-translational processing of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) N-linked glycosylation affects cell-surface expression and ligand binding. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in atherosclerosisEndothelial dysfunction and LOX-1Identification of soluble forms of lectin-like oxidized LDL receptor-1Endothelial dysfunction via lectin-like oxidized lipoprotein receptor-1: close relationships with oxidative stressAn endothelial receptor for oxidized low-density lipoprotein",
        "abstract": "Lectin-like oxidatively-modified LDL receptor-1 (LOX-1) is a major receptor for oxidized low-density lipoprotein (oxLDL) in aortic endothelial cells. Human LOX-1 (hLOX-1) gene (cDNA) was cloned from the monocytic leukemic cell line THP-1 and expressed in . The recombinant protein (rhLOX-1) was purified by his-tag affinity chromatography. Preliminary identification was performed by Western blot analysis and a ligand-receptor binding assay showed that the protein had specific oxLDL-binding activity.",
        "keywords": [
            "heterologous expression",
            "LOX-1",
            "Pichia pastoris",
            "recombinant protein"
        ],
        "authors": [
            {
                "name": "Zhentai Huang",
                "org": "Department of Biosynthesis of Natural Products,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,P.R. China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "National Pharmaceutical Screening Center, Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,P.R. China"
            },
            {
                "name": "Jinling Yang",
                "org": "Department of Biosynthesis of Natural Products,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,P.R. China"
            },
            {
                "name": "Ping Zhu",
                "org": "Department of Biosynthesis of Natural Products,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,P.R. China"
            },
            {
                "name": "Guanhua Du",
                "org": "National Pharmaceutical Screening Center, Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,P.R. China"
            },
            {
                "name": "Kedi Cheng",
                "org": "Department of Biosynthesis of Natural Products,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,P.R. China"
            }
        ],
        "venue": "Biotechnology LettersFEBS Lett.Arterioscler. Thromb. Vasc. Biol.J. Biol. Chem.Trends Cardiovasc. Med.Circ. Res.Thromb. Vasc. Biol.J. Pharmacol. Sci.Nature",
        "year": 2005
    },
    "atC3Wbnp": {
        "id": "atC3Wbnp",
        "title": "Ramulus Cinnamomi extract attenuates neuroinflammatory responses via downregulating TLR4/MyD88 signaling pathway in BV2 cells.",
        "abstract": "Ramulus Cinnamomi (RC), a traditional Chinese herb, has been used to attenuate inflammatory responses. The purpose of this study was to investigate the effect of RC extract on lipopolysaccharide (LPS)-induced neuroinflammation in BV2 microglial cells and the underlying mechanisms involved. BV2 cells were incubated with normal medium (control group), LPS, LPS plus 30 μg/mL RC extract, or LPS plus 100 μg/mL RC extract. The BV2 cell morphology was observed under an optical microscope and cell viability was detected by MTT assay. Nitric oxide level in BV2 cells was detected using Griess regents, and the levels of interleukin-6, interleukin-1β, and tumor necrosis factor α in BV2 cells were determined by ELISA. The expression levels of cyclooxygenase-2, Toll-like receptor 4 and myeloid differentiation factor 88 proteins were detected by western blot assay. Compared with the LPS group, both 30 and 100 μg/mL RC extract had no significant effect on the viability of BV2 cells. The levels of nitric oxide, interleukin-6, interleukin-1β and tumor necrosis factor α in BV2 cells were all significantly increased after LPS induction, and the levels were significantly reversed after treatment with 30 and 100 μg/mL RC extract. Furthermore, RC extract significantly inhibited the protein expression levels of cyclooxygenase-2, Toll-like receptor 4 and myeloid differentiation factor 88 in LPS-induced BV2 cells. Our findings suggest that RC extract alleviates neuroinflammation by downregulating the TLR4/MyD88 signaling pathway.",
        "keywords": [
            "BV2 cells",
            "Ramulus Cinnamomi",
            "TLR4/ MyD88 signaling pathway",
            "interleukin-1β",
            "interleukin-6",
            "lipopolysaccharide",
            "nerve regeneration",
            "neuroinflammation",
            "neuronal regeneration",
            "nitric oxide",
            "pro-inflammatory factors",
            "tumor necrosis factor α"
        ],
        "authors": [
            {
                "name": "Huan Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Xiao Cheng",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Ying-Lin Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Yue-Hua Wang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            }
        ],
        "venue": "Neural regeneration research",
        "year": 2017
    },
    "C2av28e5": {
        "id": "C2av28e5",
        "title": "High-throughput screening assay for groups of effective components extracted from Xiaoxuming Recipe]",
        "abstract": "To present a new approach for the research of effective components extracted from compounds of traditional Chinese medicine and their action mechanisms by high-throughput screening assay.We observed the anti-oxidation activities of 240 sequential components (L1-L120 and A1-A120) extracted from Xiaoxuming Recipe, the effects of these components on SH-SY5Y cells with H(2)O(2)-induced and L-glutamic acid-induced damages and the levels of resting calcium ion in neurocytes of rats.Some components (L1-L40, A100-A120) extracted from Xiaoxuming Recipe had the corresponding effects listed above. The combination of these components was regarded as the groups of effective components of Xiaoxuming Recipe in treating sequelae resulting from brain ischemia.Xiaoxuming Recipe has protective effect on brain-ischemia-induced damages through the actions of multiple components with multiple targets.",
        "keywords": [
            "brain ischemia",
            "high-throughput screening",
            "xiaoxuming decoction",
            "high throughput screening"
        ],
        "authors": [
            {
                "name": "Yue-Hua Wang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Hai-Xia Zhang",
                "org": ""
            },
            {
                "name": "Qi Li",
                "org": ""
            },
            {
                "name": "Yi Ding",
                "org": ""
            },
            {
                "name": "Juan-Juan Hu",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine",
        "year": 2006
    },
    "2OULkHT9": {
        "id": "2OULkHT9",
        "title": "Cloning and Prokaryotic Expression of Protein Tyrosine Phosphatase SHP-1 from Human Brain",
        "abstract": "With human brain mRNA as template,SHP-1 gene fragments were obtained by RT-PCR.The recombinant prokaryotic expression vector SHP-1-pEASY-E1 was constructed and transformed into E.coli TOP10.Selecting positive clonings and sequencing were conducted and recombinant plasmids were transformed into E.coli Transetta to express the SHP-1 protein.Optimizing the expressive condition of SHP-1 protein,the results showed that PCR screen and sequencing confirmed that the cDNA sequence of SHP-1 had been correctly inserted into the plasmid pEASY-E1.The optimal induction concentration of IPTG was 0.4 mmol/L,the best temperature for induction was 20 ℃.",
        "keywords": [
            "protein expression",
            "SHP-1",
            "gene cloning"
        ],
        "authors": [
            {
                "name": "LI Xiaoting",
                "org": "College of Pharmacy,Henan University,Henan Kaifeng ,China;National Center for Screening,Institute of Material Medical,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "XIE Xinmei",
                "org": "College of Pharmacy,Henan University,Henan Kaifeng ,China"
            },
            {
                "name": "ZHAO Qinghui",
                "org": "College of Pharmacy,Henan University,Henan Kaifeng ,China"
            },
            {
                "name": "PANG Xiaobin",
                "org": "College of Pharmacy,Henan University,Henan Kaifeng ,China"
            },
            {
                "name": "DU Guanhua",
                "org": "National Center for Screening,Institute of Material Medical,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Journal of Henan University(Natural Science)",
        "year": 2013
    },
    "AuYxiLvo": {
        "id": "AuYxiLvo",
        "title": "Elucidating the time-dependent changes in the urinary metabolome under doxorubicin-induced nephrotoxicity.",
        "abstract": "Doxorubicin has been indicated to be cardiotoxic and nephrotoxic, and thus it is often used as a model drug. Possible molecular mechanisms of this toxicity have been proposed, however, the systematic investigation of time-related metabolic trajectories specific to renal toxicity has rarely been reported. The present study was designed to assess time-dependent changes in doxorubicin-induced nephropathy through urinary metabolomics and to reveal the molecular mechanism based on key pathways. Urinary metabolomics revealed that the 14 day was the critical time point for model construction. Pathway analysis results showed that 5 pathways with impact (>0.01), FDR (<0.1) and p value (<0.05) were important. Furthermore, three pathways, including butanoate metabolism, alanine, aspartate and glutamate metabolism and arginine and proline metabolism, were focused on and validated by partial least squares regression analysis (PLS-RA) and molecular docking techniques. Our findings also showed that robust metabolomics combined with PLS-RA and molecular docking techniques is promising for elucidating time-dependent changes due to doxorubicin toxicity and for clarifying mechanisms, and the results provide a research foundation for the construction of a nephropathy model.",
        "keywords": [
            "PLS-RA",
            "doxorubicin",
            "metabolomics",
            "molecular docking",
            "nephrotoxicity",
            "time-dependent changes"
        ],
        "authors": [
            {
                "name": "Aiping Li",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, Shanxi, China."
            },
            {
                "name": "Wangning Zhang",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, Shanxi, China."
            },
            {
                "name": "Lichao Zhang",
                "org": "Institutes of Biomedical Sciences, Shanxi University, Taiyuan 030006, Shanxi, China."
            },
            {
                "name": "Yuetao Liu",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, Shanxi, China."
            },
            {
                "name": "Ke Li",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, Shanxi, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, Taiyuan 030006, Shanxi, China. Electronic address: qinxm@sxu.edu.cn."
            }
        ],
        "venue": "Toxicology letters",
        "year": 2019
    },
    "ny2zh1e6": {
        "id": "ny2zh1e6",
        "title": "Establishment of high throughput screening assay targeting the endonuclease activity of influenza virus PAN protein",
        "abstract": "Objective: To establish a high throughput screening (HTS) assay for the endonuclease activity of influenza virus PAN protein. Methods: The plasmid pET-28a/PAN was constructed and transformed into Escherichia coli to express PAN which was purified and concentrated next. The single-stranded circular DNA of phage M13K07 was prepared and used as a substrate (ph-DNA) of PAN endonuclease activity. The fluorescence quantitative method was applied to establish the HTS assay for PAN inhibitors, and then 100 samples selected by virtual screening strategy were evaluated. Results: PAN endonuclease had high reaction activity under the condition of 0.2 μg·mL-1 ph-DNA substrate, 1 mmol·L-1 Mn2+, pH value 9.0, temperature 37°C and reaction time 60 min. Z' factor was 0.77, indicating the assay could meet the HTS requirements, and the screening results showed that 7 samples displayed significant inhibitory activity on PAN. Conclusion: In this study, the HTS assay targeting the endonuclease activity of influenza virus PAN protein was established and optimized which was available for the screening of PAN inhibitors.",
        "keywords": [
            "Fluorescence quantitative method",
            "High throughput screening",
            "Influenza virus",
            "PAN endonuclease inhibitor"
        ],
        "authors": [
            {
                "name": "ZHOU Wei-ling",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fan Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Mian Zu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Chao Li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LIU Ai-lin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2013
    },
    "TyPA2y71": {
        "id": "TyPA2y71",
        "title": "Determination of aesculin concentration in rabbit pasma by RP-HPLC with fluorescence detector",
        "abstract": "Aim: To establish a HPLC-FLD method for determining the concentration of aesculin in rabbit plasma. Methods: The sample was separated with a C 18 column (150 mm x 4.6 mm, 5 μm) at 30°C with the mobile phase of methanol and water (74:26); A fluorescence detector was used (λex = 230 nm λem = 460 nm); The flow rate was 1 ml·min-1. Results: The retention time of aesculin was (3.620 ± 0.05) min; A good linear relationship of aesculin in the plasma samples at the concentration between 0.1 mg·L-1 and 100 mg·L-1 was observed (r = 0.997); The mean absolute recovery was 74.0%-82.6% and the lowest detective limit was 0.05 ng; Both the intra-day and inter-day precisions were less than 9.0%. After a single intravenous injection of aesculin (5 mg·kg-1) in rabbits, the T 1/2a and T1/2β were (0.196 ± 0.008)·h-1 and (6.70 ± 0.645)· h-1. Conclusions: The method was simple, sensitive and credible and could be used for the pharmacokinetic study of aesculin.",
        "keywords": [
            "Aesculin",
            "Pharmacokinetics",
            "RP-HPLC-FLD"
        ],
        "authors": [
            {
                "name": "CHEN Xiu-ping",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "WANG Yu-ying",
                "org": "Zunyi Medical College(Zunyi Medical College),Guiyang,China"
            },
            {
                "name": "Miao Wang",
                "org": "Zunyi Medical College(Zunyi Medical College),Guiyang,China"
            },
            {
                "name": "Qin Wu",
                "org": "Zunyi Medical College(Zunyi Medical College),Guiyang,China"
            },
            {
                "name": "SHI Jing-shan",
                "org": "Zunyi Medical College(Zunyi Medical College),Guiyang,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2007
    },
    "kpvtgNkW": {
        "id": "kpvtgNkW",
        "title": "Drug discovery of CLK1 inhibitors and their activity evaluation as anti-influenza viral agents (654.11)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ailin liu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2014
    },
    "GJUnIpFE": {
        "id": "GJUnIpFE",
        "title": "Overview of Modern Research on Danshen",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "juntian zhang",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "QsJZJXkC": {
        "id": "QsJZJXkC",
        "title": "[Network pharmacology study of Xiaoxuming Decoction based on vasodilatory and vasoconstrictory related GPCR targets].",
        "abstract": "In this study, bioinformatics methods such as molecular docking and network pharmacology were adopted to establish Xiaoxuming Decoction (XXMD) \"compound-vasodilatory and vasoconstrictory related G protein-coupled receptors (GPCR) targets\" network, then the vascular function regulatory effective components and the potential targets of XXMD were analyzed. Based on the XXMD herb sources, the chemical structures of the compounds were retrieved from the national scientific data sharing platform for population and health pharmaceutical information center, TCMSP database and the latest research literatures. The chemical molecular library was established after class prediction and screening for medicinal and metabolic properties. Then, five kinds of vasodilatory and vasoconstrictory related GPCR crystal structure including 5-HT receptors (5-HT1AR, 5-HT1BR), AT1R, β2-AR, hUTR and ETB were retrieved from RCSB Protein Data Bank database or constructed by homology modeling of Discovery Studio 4.1 built-in modeling tools. After virtual screening by Libdock molecular docking, the highest rated 50 compounds of each target were collected and analyzed. The collected data were further used to construct and analyze the network by Cytoscape 3.4.0. The results showed that most of the chemical composition effects were associated with different vasodilatory and vasoconstrictory related GPCR targets, while a few effective components could be applied to multiple GPCR targets at the same time, therefore forming synergies and vasorelaxant effects of XXMD.",
        "keywords": [
            " G protein-coupled receptors ",
            " Xiaoxuming Decoction ",
            " molecular docking ",
            " network pharmacology "
        ],
        "authors": [
            {
                "name": "Wen-Dan Lu",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Li Li",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yan-Jia Shen",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Rui Zhou",
                "org": "Biomedical Engineering Research Center of Kunming Medical University, Kunming 650500, China."
            },
            {
                "name": "Ran Yang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xiao-Cong Pang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2018
    },
    "F44p78eA": {
        "id": "F44p78eA",
        "title": "Low molecular weight heparin does not reduce miscarriages in non- thrombophilic IVF/ICSI-treated women.",
        "abstract": "We appreciated receiving comments from Guo (1) on our article (2), which is a meta-analysis on the efficacy of low-molecular-weight heparin (LMWH) on the outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) pregnancy in non-thrombophilic women. It highlights that the discussion on the efficacy of LMWH in assisted reproductive technology (ART) is a hot clinical topic. There are various interventions in clinic on promoting the success rate of IVF/ICSI in recent years. Among them, LWMH is a relatively safe drug for fetuses and pregnant women. The wide usage of LWMH in ART makes it worthy to be thoroughly evaluated in clinical trials. This article is protected by copyright. All rights reserved.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiu-Li Yang",
                "org": "Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing."
            },
            {
                "name": "Fei Chen",
                "org": "Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing."
            },
            {
                "name": "Xiu-Ying Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica of Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica of Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Yang Xu",
                "org": "Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing."
            }
        ],
        "venue": "Acta obstetricia et gynecologica Scandinavica",
        "year": 2018
    },
    "cHyx1Rdc": {
        "id": "cHyx1Rdc",
        "title": "Effect of Danshen on the Blood System and Microcirculatory Function",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jingyan han",
                "org": "peking union medical college"
            },
            {
                "name": "zhixin guo",
                "org": "peking union medical college"
            },
            {
                "name": "jinhua wang",
                "org": "peking union medical college"
            },
            {
                "name": "li zhang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "zrNg8tcS": {
        "id": "zrNg8tcS",
        "title": "Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain.",
        "abstract": "Embolism is responsible for at least 20% of all stroke and half of cerebral infarctions. A number of animal models have been developed to mimic thromboembolic stroke. However, little aimed directly at hippocampal damage and cognitive function. In the present study, three sizes of emboli (150-178 m, 74-124 m, and 48-74 m) were employed to induce thromboembolic stroke model in rats. Results showed that the diameter of the particle was critical for animal behavioral and histopathological consequences. Hematoxylin-eosin (HE) staining revealed that CA1 and CA2-3, which are two of the main hippocampal subdivisions were injured seriously, especially induced by emboli((48-74 m)). At 24 hr, the neurological deficit scores showed that emboli injection could cause significant neurological deficit, and the increase of neurological deficit scores correlated well to the diameter of emboli. At 60 days, emboli((150-178 m)) and emboli((48-74 m)) lead to obvious cognitive impairment, which correlated well to the hippocampal CA1 injury. Our research might be helpful to choose suitable size of emboli to induce animal model to research subcortical ischemia and vascular dementia. However, cognitive alterations and cerebral injury following different sizes of emboli injection in rats remains a topic for future investigation. Anat Rec, 2013. (c) 2013 Wiley Periodicals, Inc.",
        "keywords": [
            "hippocampal injury",
            "cognitive function",
            "different sizes of emboli",
            "cerebral thromboembolism"
        ],
        "authors": [
            {
                "name": "Heng-Ai Zhang",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Mei Gao",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Bainian Chen",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Lili Shi",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Qiaoyun Wang",
                "org": "Binzhou Med Univ, Binzhou 256603, Peoples R China"
            },
            {
                "name": "Xiaoyan Yu",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Zhaohong Xuan",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Li Gao",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Lab Drug Target Identificat & Drug Sc, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY",
        "year": 2013
    },
    "WqTeEEMf": {
        "id": "WqTeEEMf",
        "title": "Methyl salicylate 2-O-β-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes.",
        "abstract": "Neuroinflammation has been known to play a critical role in the pathogenesis of Alzheimer's disease (AD). Activation of microglia and astrocytes is a characteristic of brain inflammation. Epidemiological studies have shown that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) delays the onset of AD and suppresses its progression. Methyl salicylate-2-O-β-D-lactoside (DL0309) is a new molecule chemically related to salicylic acid. The present study aimed to evaluate the anti-inflammatory effects of DL0309.Our studies show that DL0309 significantly inhibits lipopolysaccharide (LPS)-induced release of the pro-inflammatory cytokines IL-6, IL-1β, and TNF-α; and the expression of the inflammation-related proteins iNOS, COX-1, and COX-2 by microglia and astrocytes. At a concentration of 10 μM, DL0309 prominently inhibited LPS-induced activation of NF-κB in glial cells by blocking phosphorylation of IKK and p65, and by blocking IκB degradation.We demonstrate here for the first time that DL0309 exerts anti-inflammatory effects in glial cells by suppressing different pro-inflammatory cytokines and iNOS/NO. Furthermore, it also regulates the NF-κB signaling pathway by blocking IKK and p65 activation and IκB degradation. DL0309 also acts as a non-selective COX inhibitor in glial cells. These studies suggest that DL0309 may be effective in the treatment of neuroinflammatory disorders, including AD.",
        "keywords": [
            "nitric oxide",
            "glycosides",
            "interleukin 6",
            "signal transduction",
            "tumor necrosis factor alpha",
            "molecular structure",
            "alzheimer disease"
        ],
        "authors": [
            {
                "name": "Xi Lan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Rui Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lan Sun",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of neuroinflammation",
        "year": 2011
    },
    "8CCIxSAb": {
        "id": "8CCIxSAb",
        "title": "Pinocembrin protects the neurovascular unit by reducing inflammation and extracellular proteolysis in MCAO rats: Original Article",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wencui zhang",
                "org": ""
            },
            {
                "name": "mei gao",
                "org": ""
            },
            {
                "name": "shenyin zhu",
                "org": ""
            },
            {
                "name": "chubing tan",
                "org": ""
            },
            {
                "name": "bei xu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "Journal of Asian Natural Products Research",
        "year": 2010
    },
    "dRyIx2Qm": {
        "id": "dRyIx2Qm",
        "title": "A new flavonoid from heartwood of Caesalpinia sappan]",
        "abstract": "To seek for new active components from Caesalpinia sappan.The chemical constituents were isolated and identified by means of chromatographic and spectroscopic technologies methods.Nine compounds were isolated, and their structures were identified as 3, 8-dihydroxy4, 10-dimethoxy-7-oxo-[2] benzopyrano[4,3-b] benzopyran (1), 3-deoxysappanchalcone (2), sappanchalcone (3), 3-deoxysappanone B (4), rhamnetin (5), protosappanin C (6), 3, 7-dihydroxy-chroman-4-one (7), dimethyl adipate (8), daucosterin (9).Compound 1 was a new compound, and compounds 7, 8 were isolated from this plant for the first time.",
        "keywords": [
            "10-dimethoxy-7-oxo-[2]benzopyrano[1]benzopyran-7(5h)-one",
            "cytotoxicity",
            "flavonoid",
            "8-dihydroxy-4",
            "3",
            "caesalpinia sappan"
        ],
        "authors": [
            {
                "name": "Shi-Hui Shu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine,Ministry of Education,Beijing ,China"
            },
            {
                "name": "Jing-Lan Han",
                "org": "The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine,Ministry of Education,Beijing ,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine,Ministry of Education,Beijing ,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2008
    },
    "5OFYgyu4": {
        "id": "5OFYgyu4",
        "title": "In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives.",
        "abstract": "The theaflavins fraction (TF80%, with a purity of 80%) and three theaflavin (TF) derivatives from black tea have been found to exhibit potent inhibitory effects against influenza virus in vitro. They were evaluated with a neuraminidase (NA) activity assay, a hemagglutination (HA) inhibition assay, a real-time quantitative PCR (qPCR) assay for gene expression of hemagglutinin (HA) and a cytopathic effect (CPE) reduction assay. The experimental results showed that they all exerted significant inhibitory effects on the NA of three different subtypes of influenza virus strains [A/PR/8/34(H1N1), A/Sydney/5/97(H3N2) and B/Jiangsu/10/2003] with 50% inhibitory concentration (IC(50)) values ranging from 9.27 to 36.55 μg/mL, and they also displayed an inhibitory effect on HA; these inhibitory effects might constitute two major mechanisms of their antiviral activity. Time-of-addition studies demonstrated that TF derivatives might have a direct effect on viral particle infectivity, which was consistent with the inhibitory effect on HA. Subsequently, the inhibitory effect of TF derivatives on the replication of the viral HA gene as assayed by qPCR and on the nuclear localization of the influenza virus vRNP further demonstrated that they may primarily act during the early stage of infection. Interestingly, besides the activity against functional viral proteins, TF derivatives also decreased the expression level of the inflammatory cytokine IL-6 during viral infection, expression of which may result in serious tissue injury and apoptosis. Our results indicated that TF derivatives are potential compounds with anti-influenza viral replication and anti-inflammatory properties. These findings will provide important information for new drug design and development for the treatment of influenza virus infection.",
        "keywords": [
            "anti-inflammatory",
            "antiviral",
            "influenza virus",
            "theaflavin derivatives"
        ],
        "authors": [
            {
                "name": "Mian Zu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fan Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Weiling Zhou",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Ailin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lishu Zheng",
                "org": "Chinese Center for Disease Control and Prevention(^ Chinese Center for Disease Control and Prevention),Beijing,China"
            }
        ],
        "venue": "Antiviral research",
        "year": 2012
    },
    "LWLGR9ll": {
        "id": "LWLGR9ll",
        "title": "Association of circulating levels of asymmetric dimethylarginine (ADMA) with carotid intima-media thickness: evidence from 6168 participants.",
        "abstract": "Background: Epidemiologic investigations have linked the circulating levels of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), to carotid intima-media thickness (IMT). However, these studies result in various extent of relation between ADMA and IMT, the conclusions were inconsistent, and the precise relationship is therefore under debate. The objective of this systematic review and meta-analysis is to provide an overview of the relevant studies evaluating the association of levels of ADMA with carotid IMT and to gain more robust estimate of the relationship. Methods: Studies were identified through PubMed, Cochrane Library, Embase, reviews, and reference lists of relevant papers. Weighted means of the correlation coefficient (R) and partial correlation coefficient (PR) were calculated for relations by using random-effect models. Results: 22 studies with a total of 6168 subjects were included in our meta-analysis. In an overall pooled estimate of correlation coefficient (R), levels of ADMA were significantly related to carotid IMT (pooled R: 0.29; 95% confidence interval [CI]: 0.20-0.38, P < 0.001). Pooled estimate of partial correlation coefficient (PR) also resulted in a significant association of ADMA with carotid IMT (pooled PR: 0.21; 95% CI: 0.14-0.29; P < 0.001). Furthermore, subgroup analysis found that the relation between ADMA and IMT was stronger in patients with chronic kidney diseases (CKDs) than that in subject with normal renal function. Conclusions: Circulating levels of ADMA were positively related to carotid IMT, especially in patients with CKDs. The findings need confirmation in longitudinal and interventional studies. (C) 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Asymmetric dimethylarginine (ADMA)",
            "Carotid intima-media thickness (IMT)",
            "Meta-analysis"
        ],
        "authors": [
            {
                "name": "Yongyi Bai",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Lan Sun",
                "org": "Chinese Acad Med Sci, Natl Ctr Pharmaceut Screening, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Lida Du",
                "org": "China Pharmaceut Univ, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Chinese Acad Med Sci, Natl Ctr Pharmaceut Screening, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Wenyu Xin",
                "org": "Chinese Acad Med Sci, Natl Ctr Pharmaceut Screening, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xi Lan",
                "org": "Chinese Acad Med Sci, Natl Ctr Pharmaceut Screening, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Acad Med Sci, Natl Ctr Pharmaceut Screening, Inst Mat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "AGEING RESEARCH REVIEWS",
        "year": 2013
    },
    "UE2DxvQd": {
        "id": "UE2DxvQd",
        "title": "Screening for protein tyrosine kinase inhibitors from the crude extracts of the Heat-Clearing and Detoxicating herbs",
        "abstract": "Objective: To screen potential protein tyrosine kinase(PTK) inhibitors from the crude extracts from the Heat-Clearing and Detoxicating herbs.Methods: Based on the enzyme-linked immunosorbent assay method,we screened the crude extracts from the Heat-Clearing and Detoxicating herbs from our chemical library.The samples with inhibition ratio greater than 80% were selected for the further re-screening and their IC50 values were calculated.Results: Most extracts from the Heat-Clearing and Detoxicating herbs,such as Moutan Cortex,Phellodendri Chinensis Cortex,Puerariae Lobatea Radix,Coptidis Rhizoma,Scutellariae Radix,Lonicerae Japonicae Flos,Sophorae Flavescentis Radix,Paeoniae Rubra Radix,Fraxini Cortex and Gardeniae Fructus,had potent inhibitory activities against PTKs.Conclusion: The Heat-Clearing and Detoxicating herbs may have inhibitory activities against PTKs.",
        "keywords": [
            "Crude extracts",
            "Heat-Clearing and Detoxicating",
            "Protein tyrosine kinases",
            "Screening",
            "Tumor"
        ],
        "authors": [
            {
                "name": "GUO Jing",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "FANG Lian-hua",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "CHEN Ruo-yun",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Hailin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LV Yang",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2011
    },
    "z1EcUgBd": {
        "id": "z1EcUgBd",
        "title": "Pharmacokinetics of methyl salicylate-2- O-β -D-lactoside, a novel salicylic acid analog isolated from Gaultheria yunnanensis ,in dogs: Pharmacokinetics of MSL in dogs",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "tiantai zhang",
                "org": ""
            },
            {
                "name": "weiku zhang",
                "org": ""
            },
            {
                "name": "chao huang",
                "org": ""
            },
            {
                "name": "wenyu xin",
                "org": ""
            },
            {
                "name": "xiaowei ma",
                "org": ""
            },
            {
                "name": "dan zhang",
                "org": ""
            }
        ],
        "venue": "Biomedical Chromatography",
        "year": 2013
    },
    "35Zw1hX7": {
        "id": "35Zw1hX7",
        "title": "The expression of recombinant human LOX-1 and identifying its mimic ligands by fluorescence polarization-based high throughput screening.",
        "abstract": "Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) was identified as a major receptor for oxidized low-density lipoprotein (oxLDL) in endothelial cells. LOX-1 critically mediates the endothelial dysfunction and the progression of atherosclerosis by oxLDL stimulation. It might be an important target for vascular endothelium. In order to obtain human LOX-1 and identify its mimic ligand for facilitating the study of LOX-1 function, a recombinant plasmid pPIC9K-His-hLOX-1 was structured and expressed human LOX-1 in Pichia pastoris GS115. Western blot analysis ensured the expressed recombinant human LOX-1 protein and a receptor-ligand binding assay showed that it had high binding affinity with oxLDL. With this receptor protein, a competitive fluorescence polarization-based high throughput screening method was established in a 384-well microplate to isolate the mimic ligands of human LOX-1. The evaluating parameter Z' value of 0.72 for this method showed that fluorescence polarization-based high throughput screening assay was robust and the results had a high reliability. By the fluorescence polarization-based high throughput screening assay, a total of 20,316 chemicals were screened, and 2 chemicals were identified that they have a high affinity with human LOX-1. Competitive uptake DiI-oxLDL assay by human LOX-1 transfected CHO-K1 cells further confirmed that two chemicals block the uptake of DiI-oxLDL. And the preliminary results indicated that isolated mimic ligands may act as a function of antagonist. The discovery of human LOX-1 mimic ligand would benefit to further study the function of LOX-1 and identify a novel avenue for prevention and treatment atherosclerosis.",
        "keywords": [
            "lectin-like low-density lipoprotein receptor-1",
            "atherosclerosis",
            "high throughput screening",
            "endothelial dysfunction",
            "fluorescence polarization",
            "endothelial cell",
            "binding affinity",
            "ligand binding",
            "low density lipoprotein receptor"
        ],
        "authors": [
            {
                "name": "Tiantai Zhang",
                "org": "National Centre for Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Zhentai Huang",
                "org": "Department of Natural Product Biosynthesis, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Ying Dai",
                "org": "National Centre for Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Xiuping Chen",
                "org": "National Centre for Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Ping Zhu",
                "org": "Department of Natural Product Biosynthesis, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Journal of biotechnology",
        "year": 2006
    },
    "xJdOEIWv": {
        "id": "xJdOEIWv",
        "title": "Echinacoside Protects against 6-Hydroxydopamine-Induced Mitochondrial Dysfunction and Inflammatory Responses in PC12 Cells via Reducing ROS Production.",
        "abstract": "Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. Mitochondrial dysfunction and inflammatory responses are involved in the mechanism of cell damage in PD. 6-Hydroxydopamine (6-OHDA), a dopamine analog, specifically damages dopaminergic neurons. Echinacoside (ECH) is a phenylethanoid glycoside isolated from the stems of Cistanche salsa, showing a variety of neuroprotective effects in previous studies. The present study was to investigate its effect against 6-OHDA-induced neurotoxicity and possible mechanisms in PC12 cells. The results showed that 6-OHDA reduced cell viability, decreased oxidation-reduction activity, decreased mitochondrial membrane potential, and induced mitochondria-mediated apoptosis compared with untreated PC12 cells. However, echinacoside treatment significantly attenuated these changes induced by 6-OHDA. In addition, echinacoside also could significantly alleviate the inflammatory responses induced by 6-OHDA. Further research showed that echinacoside could reduce 6-OHDA-induced ROS production in PC12 cells. These results suggest that the underlying mechanism of echinacoside against 6-OHDA-induced neurotoxicity may be involve in attenuating mitochondrial dysfunction and inflammatory responses by reducing ROS production.",
        "keywords": [],
        "authors": [
            {
                "name": "Yue-Hua Wang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Zhao-Hong Xuan",
                "org": "Shenyang Pharmaceutical University, Shenyang 110016, China."
            },
            {
                "name": "Shuo Tian",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "Evidence-based complementary and alternative medicine : eCAM",
        "year": 2015
    },
    "fYFxiSXL": {
        "id": "fYFxiSXL",
        "title": "Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation.",
        "abstract": "Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to determine the brain protective effects of SAA against cerebral ischemia reperfusion injury in rats, and to figure out whether SAA could protect the blood brain barrier (BBB) through matrix metallopeptidase 9 (MMP-9) inhibition. A focal cerebral ischemia reperfusion model was induced by middle cerebral artery occlusion (MCAO) for 1.5-h followed by 24-h reperfusion. SAA was administered intravenously at doses of 5, 10, and 20 mg·kg. SAA significantly reduced the infarct volumes and neurological deficit scores. Immunohistochemical analyses showed that SAA treatments could also improve the morphology of neurons in hippocampus CA1 and CA3 regions and increase the number of neurons. Western blotting analyses showed that SAA downregulated the levels of MMP-9 and upregulated the levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) to attenuate BBB injury. SAA treatment significantly prevented MMP-9-induced degradation of ZO-1, claudin-5 and occludin proteins. SAA also prevented cerebral NF-κB p65 activation and reduced inflammation response. Our results suggested that SAA could be a promising agent to attenuate cerebral ischemia reperfusion injury through MMP-9 inhibition and anti-inflammation activities.",
        "keywords": [
            "Blood brain barrier",
            "Ischemia",
            "MCAO",
            "MMP-9",
            "NF-κB",
            "Salvianolic acid A"
        ],
        "authors": [
            {
                "name": "Wen Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Jun-Ke Song",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xue Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Qi-Meng Zhou",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guo-Rong He",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xiao-Na Xu",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yan Rong",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Wen-Xia Zhou",
                "org": "Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China."
            },
            {
                "name": "Guan-Hua DU",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Chinese journal of natural medicines",
        "year": 2018
    },
    "gGrchoEM": {
        "id": "gGrchoEM",
        "title": "Prokaryotic Expressions of N-Terminal Sequences of BRCA2 and BRCA2a",
        "abstract": "Objective:Prokaryotic expression system was used to express N-terminal sequence of BRCA2 and BRCA2a in order to analyse the function of exon 3 of BRCA2 gene at protein level.Methods:cDNA fragments of nBRCA2 and nBRCA2a[1～18-105～500 aa] were obtained after RT-PCR amplification of cellular RNA of BT-474 cell line and inserted into pGEX-2TK vector,the transformants transformed into E.coli BL21(DE)plysS strain and checked with restriction enzyme were cultured and induced with IPTG in order to obtain fusion protein.Results & Conclusion:The recombinant plasmids,pGEX-2TK/nBRCA2 and pGEX-2TK/nBRCA2a,were constructed correctly.From SDS-PAGE result both partials of BRCA2 and BRCA2a were expressed in the manner of fusion with GST with molecular weight of 81 kD and 71 kD respectively.",
        "keywords": [
            "RT-PCR",
            "BRCA2",
            "prokaryotic expression"
        ],
        "authors": [
            {
                "name": "ZOU Jian-ping",
                "org": "Department of Neuosciences,Shenyang Pharceutical University,Shenyang "
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing "
            },
            {
                "name": "WU Chun-fu",
                "org": "Department of Neuosciences,Shenyang Pharceutical University,Shenyang "
            }
        ],
        "venue": "Letters in Biotechnology",
        "year": 2007
    },
    "9q2CJ9yb": {
        "id": "9q2CJ9yb",
        "title": "Anti-oxidative effect of Terminalia chebula Retz",
        "abstract": "Inhibitation rates of liver microsome lipid peroxidation in FeSO4/cysoxidative system were measured.Inhibitation rates of hemolysis caused H2O2 and self-oxidation were measured.DPPH free radical scavenging capacity was assayed.Our results showed that Terminalia chebula Retz ethanol extract can inhibit the liver microsome lipid peroxidation caused by FeSO4/cys and inhibit haemolysis caused by H2O2 and self-oxidation,that DPPH free radical was scavenged by Terminalia chebula Retz ethanol extract.It was concluded that Terminalia chebula Retz has anti-oxidative effect.",
        "keywords": [
            "Terminalia chebula Retz(诃子)",
            "fyee radicie",
            "haemolysis"
        ],
        "authors": [
            {
                "name": "Jinhua Wang",
                "org": "1 Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing  "
            },
            {
                "name": "Fangyun Sun",
                "org": "2 Tibet national college medicine department,Xianyang "
            },
            {
                "name": "Dongya Yuan",
                "org": "2 Tibet national college medicine department,Xianyang "
            },
            {
                "name": "Min Zhang",
                "org": "2 Tibet national college medicine department,Xianyang "
            },
            {
                "name": "Guanhua Du",
                "org": "1 Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing  "
            }
        ],
        "venue": "Pharmacology and Clinics of Chinese Materia Medica",
        "year": 2012
    },
    "OPSKp64G": {
        "id": "OPSKp64G",
        "title": "Syntheses and structure-activity relationships in cytotoxicities of 13-substituted quaternary coptisine derivatives.",
        "abstract": "Twenty five 13-substituted quaternary coptisine derivatives were synthesized to test their cytotoxicities against several cancer cell-lines and on intestinal epithelial cell-6 (IEC-6) in vitro to evaluate structure-activity relationship (SAR). Introduction of the alkyl groups into the C-13 position of quaternary coptisine (1) led to significant increase of the cytotoxic activity, while the substitution of arylmethyl groups and others at the same position showed no effect on improving cytotoxicities against the same cancer cell-lines. The cytotoxicities of quaternary 13-alkylcoptisines was significantly reinforced as the length of the aliphatic chain increased, with quaternary 13-n-undecylcoptisine (4l) showing 7, 23, 12, and 9 times, respectively, more active than quaternary coptisine (1) against HCT, A549, Bel7402, and C33A, and being 4, 11, 2, and 3 times, respectively, more active than the positive control, fluorouracil (5-FU), against the same cell-lines, by IC50 values. In comparison to quaternary 13-n-undecylcoptisine (4l) and the above references, quaternary 13-n-dodecylcoptisine (4m) almost showed the same cytotoxicities. In contrast with the n-alkyl chains, the arylmethyl substituents at C-13 displayed low cytotoxicity, except for naphthyl rings or phenyl rings with CF3 or methyl substituents. However, their low cytotoxicity could make them useful as drug candidates for other diseases (bowel, etc).",
        "keywords": [
            "alkyl group",
            "arylmethyl group",
            "cytotoxicity",
            "quaternary 13-substituted coptisines",
            "structure–activity relationship",
            "synthesis",
            "structure activity relationship"
        ],
        "authors": [
            {
                "name": "Zhi-Hui Zhang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "An-Jun Deng",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Lian-Qiu Wu",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Lian-Hua Fang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Jin-Qian Yu",
                "org": "Shandong Analysis and Test Center, Shandong Academy of Sciences, Jinan 250014, PR China."
            },
            {
                "name": "Zhi-Hong Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Tian-Yi Yuan",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Wen-Jie Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Hai-Lin Qin",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            }
        ],
        "venue": "European journal of medicinal chemistry",
        "year": 2014
    },
    "5Bnp9jzA": {
        "id": "5Bnp9jzA",
        "title": "Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats",
        "abstract": "Increasing studies have shown that dyslipidemia and inflammatory responses play important roles in the progression of microvascular diabetic complications. Esculin (ES), a coumarin derivative, was extracted from Fraxinus rhynchophylla. The present study was to evaluate the potential effects of ES on lipid metabolism, inflammation responses and renal damage in streptozotocin (STZ)-induced experimental diabetic rats and explore the possible mechanism.Diabetic rat model was established by administration high-glucose-fat diet and intraperitoneal injection of STZ 45 mg/kg. ES was administrated to diabetic rats intragastrically at 10, 30 and 90 mg/kg for 10 weeks respectively. The levels of triglycerides (TG), total cholesterol (T-CHO), low density lipoproteins (LDL), and high-density-cholesterol (HDL-C) in serum were measured. IL-1, IL-6, ICAM-1, NO, NAGL, and AGEs level in serum were detected by ELISA assay. The accumulation of AGEs in kidney tissue was examined by immunohistochemistry assay.The results showed that ES could decrease TG, T-CHO, LDL levels in serum of diabetic rats in a dose dependent manner. ES also decreased IL-1, IL-6, ICAM-1, NO and NGAL levels in serum of diabetic rats in a dose dependent manner. Furthermore, ES at 30 and 90 mg/kg significantly decreased AGEs level in serum and alleviated AGEs accumulation in renal in diabetic rats.Our findings indicate that ES could improve dyslipidemia, inflammation responses, renal damage in STZ-induced diabetic rats and the possible mechanism might be associated with the inhibition of AGEs formation.",
        "keywords": [
            "internal medicine"
        ],
        "authors": [
            {
                "name": "Yue-Hua Wang",
                "org": "Beijing Key Laboratory of Drug Target Identification,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China"
            },
            {
                "name": "Yan-Hong Liu",
                "org": "china pharmaceutical university"
            },
            {
                "name": "Guo-Rong He",
                "org": "Beijing Key Laboratory of Drug Target Identification,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China"
            },
            {
                "name": "yang lv",
                "org": "Beijing Key Laboratory of Drug Crystal Research,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China"
            }
        ],
        "venue": "BMC Complementary and Alternative Medicine",
        "year": 2015
    },
    "kiawYY7f": {
        "id": "kiawYY7f",
        "title": "Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).",
        "abstract": "Our previous work suggested that baicalein could delay senescence and improve cognitive dysfunction in senescence-accelerated mouse prone 8 (SAMP8). Although baicalein has shown therapeutical benefits in improving learning and memory impairment, the exact molecular mechanisms have not been fully understood. In the present work, transcriptomics was integrated with gene network analysis for revealing the potential mechanisms of baicalein in improving learning and memory in SAMP8 mice. The results showed that baicalein regulated fifty hub differently expressed genes (DEGs) that were enriched in eight signaling pathways. Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway was especially significant among them, therefore, the DEGs (Gh1, Il5, Il7, Il20rb, Prlr and Socs1) in JAK-STAT signaling pathway were verified by quantitative real-time PCR, and the key proteins (JAK2, p-JAK2, STAT1 and p-STAT1) and related proteins including β-amyloid peptide (Aβ) and receptor for advanced glycation end products (RAGE) were assayed by Western blot and enzyme-linked immunosorbent assay. Our results suggest that baicalein prevented the activation of JAK2/STAT1 signaling pathway and decreased the levels of Aβ and RAGE in the cortex of SAMP8 mice. Taken together, our study unmasks the mechanism of baicalein on improving learning and memory impairment in SAMP8 mice, which is dependent upon the inhibition of Aβ and RAGE/JAK2/STAT1 cascade.",
        "keywords": [
            "Baicalein",
            "Learning and memory",
            "Network analysis",
            "SAMP8",
            "Transcriptomics"
        ],
        "authors": [
            {
                "name": "Jiaqi Li",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China."
            },
            {
                "name": "Yuzhi Zhou",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China."
            },
            {
                "name": "Guanhua Du",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China. Electronic address: qinxm@sxu.edu.cn."
            },
            {
                "name": "Li Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China. Electronic address: gaoli87@sxu.edu.cn."
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2019
    },
    "sie4NKpt": {
        "id": "sie4NKpt",
        "title": "Study on screening strategy of anti-arrhythmic drugs",
        "abstract": "Anti-arrhythmic drug is basic therapy for the treatment of arrhythmias, the large randomized placebo-controlled clinical trails have shown that most anti-arrhythmic drugs have limited overall success and can sometimes induce arrhythmias, and even do not decrease mortality. This paper briefly reviews the history of anti-arrhythmic drugs, the problems, the progresses and the novel strategies for screening of anti-arrhythmic drugs.",
        "keywords": [
            "arrhythmia",
            "ionic channel",
            "target spot",
            "new drug screening"
        ],
        "authors": [
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing ,China"
            }
        ],
        "venue": "Journal of Harbin University of Commerce(Sciences Edition)",
        "year": 2005
    },
    "IRfuHkBz": {
        "id": "IRfuHkBz",
        "title": "Determination of Lutin in Oat Bran",
        "abstract": "Objective:To develop an HPLC method for determination of Lutin in oat bran.Methods:The methanol extract of oat bran was dissolved by methanol and Lutin was measured by HPLC(mobile phase:CH3OH:0.4%H3PO4=45:55;flow rate:1.0mL/min;temperature:30°C;wave length:360nm) .Results:The calibration curve was in good linearity over the range of 0.025～0.125μg with the regression equation of y=0.0007x-0.0029(r=0.9997) and the average recovery was 99.58%(RSD=1.32%) .Conclusion:The method is simple,quick and reproducible and can be applied in the quality control of oat bran.",
        "keywords": [
            "Lutin",
            "Oat Bran",
            "Avena Sativa Linn."
        ],
        "authors": [
            {
                "name": "Zhang Weiku",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Xu Jiekun",
                "org": "School of Preclinical Medicine,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "Zhao Ying",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Du Guanhua",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Asia-Pacific Traditional Medicine",
        "year": 2010
    },
    "YkAPYYuI": {
        "id": "YkAPYYuI",
        "title": "Synthesis and preliminary evaluation of peptidomimetic inhibitors of human beta-secretase.",
        "abstract": "Based on the structure of OM99-2 and the X-ray crystal structure of its complex with beta-secretase, a series of compounds containing the Leu*Ala hydroxyethylene isostere as a scissile bond substitution were designed. 31 compounds were synthesized and their beta-secretase inhibition activities were measured. It was found that isobutyl group was a better R3 substitution as C-terminus in our target compounds, and 4-nitrobenzyl group was the best R2 side chain. With the aid of molecular modeling, the binding modes of compounds 9 and 22 with beta-secretase were compared. The result revealed a stronger bonding mode of 22 than 9. This explored that the optimal length of this series of peptidomimetic inhibitors was P3-P2'. The molecular weights of compounds with this length are around 600.",
        "keywords": [],
        "authors": [
            {
                "name": "Yan Niu",
                "org": "Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing 100191, PR China."
            },
            {
                "name": "Yuehua Wang",
                "org": ""
            },
            {
                "name": "Xiaomin Zou",
                "org": ""
            },
            {
                "name": "Xiaoming Yang",
                "org": ""
            },
            {
                "name": "Chao Ma",
                "org": ""
            },
            {
                "name": "Yang Lü",
                "org": ""
            },
            {
                "name": "Bo Zhou",
                "org": ""
            },
            {
                "name": "Yue Yuan",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            },
            {
                "name": "Ping Xu",
                "org": ""
            }
        ],
        "venue": "European journal of medicinal chemistry",
        "year": 2010
    },
    "evh3V6zS": {
        "id": "evh3V6zS",
        "title": "Quercetin protects against the Aβ-induced amnesic injury through inhibiting RAGE-mediated pathway and preserving the neurovascular unit",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Liu",
                "org": ""
            },
            {
                "name": "Dan Zhou",
                "org": ""
            },
            {
                "name": "Xiaoyu Bai",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2016
    },
    "5AoWV7A2": {
        "id": "5AoWV7A2",
        "title": "Baicalein exerts neuroprotective effects in 6-hydroxydopamine induced experimental Parkisonism (LB625)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xin mu",
                "org": ""
            },
            {
                "name": "yang lu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2014
    },
    "j6in8SdT": {
        "id": "j6in8SdT",
        "title": "Solubility and Stability Advantages of a New Cocrystal of Berberine Chloride with Fumaric Acid.",
        "abstract": "BBC is a drug with a variety of activities but poor solubility. Cocrystal technology is an effective method to improve the solubility and stability of this type of compound. In this work, the cocrystal of BBC with fumaric acid was obtained at a stoichiometric ratio of 2:1. Studies on stabilities and solubilities were carried out using BBC dihydrate and tetrahydrate as reference materials. Results showed that this new cocrystal did not only significantly improve the dissolution rate of BBC but also highly improved the stability in high humidity and temperature. Given that the cocrystals formed by BBC as the host molecule were few, different techniques were applied for characterization and structural analyses. Moreover, theoretical calculations were performed on weak interactions, such as hydrogen bonding and π-π stacking interactions, which provided the research data for the study of this kind of cocrystal.",
        "keywords": "",
        "authors": [
            {
                "name": "Dezhi Yang",
                "org": "Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of MateriaMedica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Junzi Cao",
                "org": "Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of MateriaMedica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Lingtai Jiao",
                "org": "Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of MateriaMedica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Shiying Yang",
                "org": "Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of MateriaMedica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Li Zhang",
                "org": "Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of MateriaMedica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yang Lu",
                "org": "Beijing City Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Institute of MateriaMedica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing City Key Laboratory of Drug Target and Screening Research, National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "ACS omega",
        "year": 2020
    },
    "0Y5YOpSW": {
        "id": "0Y5YOpSW",
        "title": "Therapeutic effects of baicalein on rotenone-induced Parkinson's disease through protecting mitochondrial function and biogenesis.",
        "abstract": "Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD) for several decades, and disturbed mitochondrial biogenesis (mitobiogenesis) was recently found to be a common phenomenon in PD. Baicalein, a major bioactive flavone of Scutellaria baicalensis Georgi, exerted neuroprotective effects in several experimental PD models. However, the effects of baicalein in rotenone-induced PD rats and the possible mechanisms remain poorly understood. In this study, we evaluated the therapeutic effects of baicalein and explored its mechanism of action in rotenone-induced PD models. The results indicated that behavioural impairments and the depletion of dopaminergic neurons induced by rotenone were attenuated by baicalein. Furthermore, in rotenone-induced parkinsonian rats, baicalein treatment effectively restored mitochondrial function and improved mitobiogenesis, as determined by measuring the mitochondrial density and key regulators involved in mitobiogenesis. Additionally, we confirmed that baicalein enhanced mitobiogenesis through the cAMP-responsive element binding protein (CREB) and glycogen synthase kinase-3β (GSK-3β) pathways in rotenone-treated SH-SY5Y cells. Moreover, we demonstrated that the cytoprotective effects of baicalein could be attenuated by the mitobiogenesis inhibitor chloramphenicol as well as CREB siRNA transfection. Overall, our results suggested that baicalein partially enhanced mitobiogenesis to restore mitochondrial function, thus exerting therapeutic effects in rotenone-induced PD models.",
        "keywords": "",
        "authors": [
            {
                "name": "Xue Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China."
            },
            {
                "name": "Lida Du",
                "org": "School of Biomedical Science, The Chinese University of Hong Kong, Hong Kong, S.A.R., China."
            },
            {
                "name": "Wen Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China."
            },
            {
                "name": "Yulin Yang",
                "org": "Guangdong Pharmaceutical University, Guangzhou, 510006, China."
            },
            {
                "name": "Qimeng Zhou",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "Scientific reports",
        "year": 2017
    },
    "HGO9vBy9": {
        "id": "HGO9vBy9",
        "title": "The present situation and development direction of the research for polymorphic drugs in China",
        "abstract": "Solid drug polymorphism can affect the clinical efficacy and safety,as well as quality and stability.The research of solid drug polymorphism is of importance in the quality control and management of drugs.Therefore,the polymorphism research is strongly emphasized in the field of international drug R&D and management.In this review,the present situation of research and management of polymorphic drugs in China is summarized and analyzed.The development direction of the research and management of polymorphic drugs in China will be suggested scientifically on the basis of the latest research achievements and the management experiences in western developed countries.",
        "keywords": [
            "polymorphism",
            "preparation",
            "polymorphic drugs",
            "drug substance"
        ],
        "authors": [
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2009
    },
    "a60RTueU": {
        "id": "a60RTueU",
        "title": "Protective effects of icariin on cerebral mitochondria function in SAMP8 mice",
        "abstract": "AIM:To investigate the protective effects of icariin (ICA) on cerebral mitochondria in senescence accelerated mice (SAM). METHODS: The 8-month-old senescence-accelerated mouse prone /8(SAMP8) mice were divided into SAMP8 group, Donepezil Hydrochloride (DON)-treated SAMP8 group (1 mg/kg), Piracetam (PIR)-treated SAMP8 group (200 mg/kg) and ICA-treated SAMP8 groups (75 mg/kg and 150 mg/kg). The age-matched senescence-accelerated mouse resistance 1( SAMR1) mice served as control. After treatment for 30 d, the cerebral mitochondria were isolated. The ATP production, reactive oxygen species (ROS) level, oxidative phosphorylation parameters and mitochondrial permeability transition pore (MPTP) were detected to evaluate the function of mitochondria in SAM mice. RESULTS:Respiratory control index, ADP/O ratio, State Ⅲ respiration and oxidative phosphorylation rate (OPR) were significantly lower in SAMP8 than those in SAMR1(P<0.05). State Ⅳ respiration did not significantly change in SAMP8 compared with that in SAMR1. At the same time, the loss of mitochondrial membrane potential(MMP), the decreased of ATP content, the increase of mitochondrial swelling degree and the increased level of ROS were also observed in SAMP8 brain mitochondria. ICA at the dosage of 75 mg/kg and 150 mg/kg significantly improved oxidative phosphorylation process, mitochondria swelling degree, MMP and other biochemical functions. CONCLUSION: ICA has a protective effect on cerebral mitochondrial impairment in SAMP8 mice.",
        "keywords": [
            "Icariin",
            "Alzheimer's disease",
            "Mitochondria",
            "Senescence accelerated mice"
        ],
        "authors": [
            {
                "name": "WU Man-gang",
                "org": "Life Science and Environment Science Research Center, Harbin University of Commerce, Herbin , Heilongjiang,China"
            },
            {
                "name": "HE Xiao-li",
                "org": "Research Center for Pharmacology and Toxicology, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal Plant Development, Beijing ,China"
            },
            {
                "name": "QIANG Gui-fen",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing  ,China"
            },
            {
                "name": "SHI Li-li",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing  ,China"
            },
            {
                "name": "LI Xiao-xiu",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing  ,China"
            },
            {
                "name": "ZU Mian",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing  ,China"
            },
            {
                "name": "LIU Dong-hua",
                "org": "Life Science and Environment Science Research Center, Harbin University of Commerce, Herbin , Heilongjiang,China"
            },
            {
                "name": "BI Ming-gang",
                "org": "Research Center for Pharmacology and Toxicology, Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal Plant Development, Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing  ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Pharmacology and Therapeutics",
        "year": 2010
    },
    "0kCSw1p2": {
        "id": "0kCSw1p2",
        "title": "Polymorphism Analysis of Fluconazole by Raman Spectroscopy",
        "abstract": "OBJECTIVE To established a method for identification of different polymorpbs of fluconazole by Raman spectra.METHODS The analysis was performed by dispersive 780nm Raman system.Raman spectra of polymorphs A and B of fluconazole were obtained,and the result was verified by DSC,FTIR and Power X Ray Diffraction(PXRD).Without any pre-treatment,Raman analysis was directly carried on three different fluconazole solid oral products and the polymorphs A or B of fluconazole in the raw material was indicated by Raman spectra.The distribution of polymorphism contents was studied by Raman imaging technology.RESULTS The characteristic Raman spectra of polymorphs A and B of fluconazole were obtained.And the polymorphisms of the three test products were determined.Sample T1 contained polymorph A and starch or dextrin as the main excipient.Sample T3 contained polymorph B and lactose as the main excipient.CONCLUSION The polymorphs A and B of fluconazole in the raw material and solid oral products can be easily and quickly identified by Raman analysis.",
        "keywords": [
            "polymorphism",
            "fluconazole",
            "raman imaging",
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "LIN lin",
                "org": "National Instituted for the Food and Drug Control,Beijing ,China"
            },
            {
                "name": "LI Xiao-dong",
                "org": "National Instituted for the Food and Drug Control,Beijing ,China"
            },
            {
                "name": "DING Li-xia",
                "org": "National Instituted for the Food and Drug Control,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2012
    },
    "AZRFhQm9": {
        "id": "AZRFhQm9",
        "title": "Effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes.",
        "abstract": "Currently there is no effective treatment for nonalcoholic fatty liver disease (NAFLD), especially hepatic fibrosis induced by type 2 diabetes. Valsartan maybe has beneficial effect on the liver disease. The aim of the present study was to investigate the effect of valsartan on the pathological progression of hepatic fibrosis in rats with type 2 diabetes. An animal model of hepatic fibrosis with type 2 diabetes was developed using a high-sucrose, high-fat diet and low-dose streptozotocin. Valsartan (15 mg/kg/day, i.g.) was orally administered for four months. The livers were removed to make hematoxylin-eosin (HE) staining and Picric acid-Sirius red staining, and immunohistochemistry staining of α-smooth-muscle-actin (α-SMA), transforming growth factor β1 (TGF-β1), tumor necrosis factor (TNF-α) and monocyte chemotactic protein-1 (MCP-1). Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining was performed to detect hepatocyte apoptosis. The liver mitochondria were isolated to measure the mitochondrial respiratory function. The results showed that valsartan significantly alleviated the lesion of hepatic steatosis and hepatic fibrosis by HE staining and Picric acid-Sirius red staining. Immunohistochemical staining suggested that the expression of α-SMA, TGF-β1, TNF-α and MCP-1 in liver tissue of diabetic rats was markedly reduced by valsartan. TUNEL staining showed that there were fewer TUNEL-positive apoptotic hepatocytes in valsartan group. In addition, valsartan restored the injured hepatic mitochondrial respiratory function. The findings demonstrated that valsartan prevented the pathological progression of hepatic fibrosis in type 2 diabetic rats, correlated with reducing α-SMA, TGF-β1, TNF-α and MCP-1 expression, also anti-apoptosis and mitochondria-protective potential.",
        "keywords": [
            "pathological progression",
            "type 2 diabetes",
            "nonalcoholic fatty liver disease",
            "valsartan",
            "hepatic fibrosis"
        ],
        "authors": [
            {
                "name": "Guifen Qiang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Qi Xuan",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lili Shi",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hengai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Bainian Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiaoxiu Li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Mian Zu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dan Zhou",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Jing Guo",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Haiguang Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2012
    },
    "0a216s9h": {
        "id": "0a216s9h",
        "title": "Fluorescein Diacetate Microplate Assay in Cell Viability Detection.",
        "abstract": "Objective To investigate the application of the fluorescein diacetate (FDA) microplate assay in cell viability detection. Methods Cells were seeded in a 96-well culture plate until detection. After incubated with FDA,the plate was detected by fluorescence microplate analyzer. The effects of FDA incubation duration,concentration,and other factors on the assay's accuracy and stability were assessed. We also compared the results of FDA with methyl thiazolyl(MTT) in terms of cell numbers and HO injury. Results Within 0-30 minutes,the fluorescence-cell number coefficient of FDA assay increased with duration and reached 0.99 in 27-30 minutes. The optimum concentration of final FDA in this study was 10-30 μg/ml. On cell viability detection,the result of FDA method was equivalent to MTT method. As to HO injury assay,the sensitivity of FDA method was superior to MTT on the higher concentration HO treatment due to a relative shorter duration for detection. Conclusion As a stable and reliable method,FDA is feasible for cell variability detection under varied conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Chen",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, CAMS and PUMC,Beijing 100050,China."
            },
            {
                "name": "Xiu-Ying Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, CAMS and PUMC,Beijing 100050,China."
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, CAMS and PUMC,Beijing 100050,China."
            },
            {
                "name": "Guan-Hua DU",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, CAMS and PUMC,Beijing 100050,China."
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2016
    },
    "oFWmH5iG": {
        "id": "oFWmH5iG",
        "title": "Study on pharmacokinetics of thalidomide polymorphs in rats",
        "abstract": "Aim To study the gastrointestinal absorption process of thalidomide polymorphs in SD rats thus to find out the optimal crystal form and explore the factors that may affect the clinical effects of thalidomide.Method Each rat was intragastrically given one of three crystal forms of thalidomide.In plasma concentration of thalidomide were determined by HPLC method.The pharmacokinetic parameters were calculated and compared among polymorphs.Result The main pharmacokinetic parameters of thalidomide form α,β and γ were as follows;C max were 6.79,4.28 and 5.55 mg.L-1;T max were 8.33,8.00 and h;AUC 0→t were 40.73,30.34 and 38.74 mg.h.L-1;T1 2 were 2.29,1.95 and 1.93 h,respectively.Conclusion Thalidomide form α has the highest peak concentration and its plasma concentration is maintained for a longer time than others.",
        "keywords": [
            "HPLC",
            "drug polymorphs",
            "rats",
            "pharmacokinetics",
            "plasma concentration",
            "thalidomide"
        ],
        "authors": [
            {
                "name": "WANG Su-bo",
                "org": "aboratory of Drug Targets Identification and Drug Screening,2.Beijing Key Laboratory of Drug Crystal Form Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing )"
            },
            {
                "name": "CHEN Qian-xi",
                "org": "aboratory of Drug Targets Identification and Drug Screening,2.Beijing Key Laboratory of Drug Crystal Form Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing )"
            },
            {
                "name": "FANG Lian-hua",
                "org": "aboratory of Drug Targets Identification and Drug Screening,2.Beijing Key Laboratory of Drug Crystal Form Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing )"
            },
            {
                "name": "y L",
                "org": "aboratory of Drug Targets Identification and Drug Screening,2.Beijing Key Laboratory of Drug Crystal Form Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing )"
            },
            {
                "name": "DU Guan-hua",
                "org": "aboratory of Drug Targets Identification and Drug Screening,2.Beijing Key Laboratory of Drug Crystal Form Research,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing )"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2012
    },
    "TBUCFxRO": {
        "id": "TBUCFxRO",
        "title": "Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB.",
        "abstract": "Abnormal vascular smooth muscle cell (VSMC) proliferation and migration contribute to the pathogenesis of vascular diseases including atherosclerosis and restenosis. Brazilin isolated from the heartwood of Caesalpinia sappan L. has been reported to exhibit various biological activities, such as anti-platelet aggregation, anti-inflammation, vasorelaxation and pro-apoptosis. However, the functional effects of Brazilin on VSMCs remain unexplored. The present study investigated the potential effects of Brazilin on platelet-derived growth factor (PDGF)-BB induced VSMC proliferation and migration as well as the underlying mechanism of action. VSMC proliferation and migration were measured by Crystal Violet Staining, wound-healing and Boyden chamber assays, respectively. Cell cycle was analyzed by flow cytometry. Enzymatic action of matrix metalloproteinase-9 (MMP-9) was carried out by gelatin zymography. Expression of adhesion molecules, cell cycle regulatory proteins, the phosphorylated levels of PDGF receptor beta (PDGF-R beta), Src, extra-cellular signal regulated kinase (ERK) and Akt were tested by immunoblotting. The present study demonstrated that pretreatment with Brazilin dose-dependently inhibited PDGF-BB stimulated VSMC proliferation and migration, which were associated with a cell-cycle arrest at G0/G1 phase, a reduction in the adhesion molecule expression and MMP-9 activation in VSMCs. Furthermore, the increase in PDGF-R beta, Src, ERK1/2 and Akt phosphorylation induced by PDGF-BB were suppressed by Brazilin. These findings indicate that Brazilin inhibits PDGF-BB induced VSMC proliferation and migration, and the inhibitory effects of Brazilin may be associated with the blockade of PDGF-R beta - ERK1/2 and Akt signaling pathways. In conclusion, the present study implicates that Brazilin may be useful as an anti-proliferative agent for the treatment of vascular diseases.",
        "keywords": [
            "Brazilin",
            "Vascular Smooth Muscle Cell",
            "Proliferation",
            "Migration",
            "PDGF"
        ],
        "authors": [
            {
                "name": "Jing Guo",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Li Li",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Yu-Jie Wu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China; Peking Union Med Coll, Beijing 100050, Peoples R China"
            },
            {
                "name": "Yu Yan",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China; Peking Union Med Coll, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xiao-Na Xu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China; Peking Union Med Coll, Beijing 100050, Peoples R China"
            },
            {
                "name": "Shou-Bao Wang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Tian-Yi Yuan",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China; Peking Union Med Coll, Beijing 100050, Peoples R China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Targets Identificat & Drug S, Beijing 100050, Peoples R China; Peking Union Med Coll, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "AMERICAN JOURNAL OF CHINESE MEDICINE",
        "year": 2013
    },
    "kCzxeiNJ": {
        "id": "kCzxeiNJ",
        "title": "A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1.",
        "abstract": "Broad spectrum Bcl-2 small molecule inhibitors act as BH3 mimetics are effective antitumor agents. Herein, we have identified S1, a previously discovered small molecule Bcl-2 inhibitor, as the first authentic BH3 mimetic as well as a dual, nanomolar inhibitor of Bcl-2 and Mcl-1 (K(i) = 310 nM and 58 nM, respectively). The results of fluorescence polarization assays, coimmunoprecipitation, fluorescent resonance energy transfer, and shRNA indicated that S1 can disrupt Bcl-2/Bax, Mcl-1/Bak and Bcl-2/Bim heterodimerization in multiple cell lines, activate Bax accompanied by its translocation to mitochondrial, activate caspase 3 completely dependent on Bax/Bak, and in turn induce a Bim-independent apoptosis. Moreover, S1 could induce apoptosis on the primary acute lymphoblastic leukemia cells regardless of Mcl-1 level. Mechanism-based single agent antitumor activity in a mouse xenograft H22 (mouse liver carcinoma) model ascertain its therapeutic potential. S1 represents a novel chemical class of antitumor leads that function solely as BH3 mimetics and pan-Bcl-2 inhibitors. In the meanwhile, S1 could become a unique tool for interactions between Bcl-2 family proteins.",
        "keywords": [
            "bcl-2",
            "bh3 mimetics",
            "mcl-1",
            "pan-bcl-2 inhibitor",
            "bcl 2"
        ],
        "authors": [
            {
                "name": "Zhichao Zhang",
                "org": ""
            },
            {
                "name": "Ting Song",
                "org": ""
            },
            {
                "name": "Tiantai Zhang",
                "org": ""
            },
            {
                "name": "Jin Gao",
                "org": ""
            },
            {
                "name": "Guiye Wu",
                "org": ""
            },
            {
                "name": "Lijia An",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "International journal of cancer. Journal international du cancer",
        "year": 2011
    },
    "t6DKtiVs": {
        "id": "t6DKtiVs",
        "title": "High-throughput fluorescence polarization method for identifying ligands of LOX-1.",
        "abstract": "To develop and optimize a competitive fluorescence polarization (FP) method, and use it as a high-throughput screening (HTS) assay for drug discovery.Human lectin-like oxidized low-density lipoprotein receptor-1 (hLOX-1) and oxidized low-density lipoprotein (oxLDL) were used to establish a high-throughput fluorescence polarization assay to screen ligands of human LOX-1. A 96-well plate assay was performed with a fast plate reader. Three fluorescein isothiocyanate-labeled hLOX-1 concentrations (100, 200, and 400 nmol/L) were selected to be titrated by oxLDL (from 0.05 nmol/L to 100 micromol/L) in order to obtain optimal reactive concentrations. The concentration of Me2SO used (0%, 1%, 3%, 5%) and incubation time (15 min, 30 min, 1 h, 2 h) were optimized. The Z' factor was calculated to estimate the quality of FP-based HTS.Concentrations of 200 nmol/L for human LOX-1 and 50 micromol/L for oxLDL were used in the actual assay. Concentrations of 0% to 5% Me2SO and different reaction times did not affect the FP-based HTS. The Z' value was 0.66. By using this detection and screening system, 12 700 compounds were screened and 3 ligands with an IC50 of less than 4.5 micromol/L were found.The established competitive FP-based assay is sensitive, stable, highly reproducible and robust, and suitable for HTS for ligands of the hLOX-1 receptor.",
        "keywords": [
            "ldl receptors",
            "oxidized low density lipoprotein",
            "high-throughput screening",
            "fluorescence polarization assay",
            "pharmacokinetics",
            "clinical pharmacology",
            "genitourinary",
            "neuropharmacology",
            "drug discovery",
            "pharmaceutics",
            "high throughput screening",
            "pharmacology"
        ],
        "authors": [
            {
                "name": "Tian-Tai Zhang",
                "org": ""
            },
            {
                "name": "Zhen-Tai Huang",
                "org": ""
            },
            {
                "name": "Ying Dai",
                "org": ""
            },
            {
                "name": "Xiu-Ping Chen",
                "org": ""
            },
            {
                "name": "Ping Zhu",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Acta pharmacologica Sinica",
        "year": 2006
    },
    "hlNlxroS": {
        "id": "hlNlxroS",
        "title": "The Discussion on strategy improving the safety in human bioequivalence study",
        "abstract": "The human bioequivalence (BE) study is simple, but the safety of study should not be ignored. Referring to the guideline on BE study of generic drugs issued by FDA, we summarized a series of experiences concerning subjects' safety based on a number of BE studies we finished. For the special drugs that may influence safety of subjects, we should deliberately take the safety and rights of subjects into considerations from clinical trial design, investigational products, subject screening, and clinical monitoring to the collection of biological samples. These will reduce the exposure risk of subjects. In this paper, we discussed the strategy improving the safety of human BE study in order to supply the constructive suggestions for standardizing the design and improving the safety of BE study in China.",
        "keywords": [
            "Bioequivalence study",
            "Generic drug",
            "Safety"
        ],
        "authors": [
            {
                "name": "QIANG Gui-fen",
                "org": "Aerospace Center Hospital(Aerospace Center Hospital,Central Hospital of Aerospace Bureau,Thirteen Department of Aerospace Central Hospital),Beijing,China"
            },
            {
                "name": "Man Yang",
                "org": "Aerospace Center Hospital(Aerospace Center Hospital,Central Hospital of Aerospace Bureau,Thirteen Department of Aerospace Central Hospital),Beijing,China"
            },
            {
                "name": "ZHANG Ya-nan",
                "org": "Aerospace Center Hospital(Aerospace Center Hospital,Central Hospital of Aerospace Bureau,Thirteen Department of Aerospace Central Hospital),Beijing,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LIU Hui-chen",
                "org": "Aerospace Center Hospital(Aerospace Center Hospital,Central Hospital of Aerospace Bureau,Thirteen Department of Aerospace Central Hospital),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2011
    },
    "k1TgmVIU": {
        "id": "k1TgmVIU",
        "title": "Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca 2+ ] i and ERK1/2 activation through blocking AT 1 R in the rat aorta",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "li li",
                "org": ""
            },
            {
                "name": "xiaobin pang",
                "org": ""
            },
            {
                "name": "bainian chen",
                "org": ""
            },
            {
                "name": "li gao",
                "org": ""
            },
            {
                "name": "le wang",
                "org": ""
            },
            {
                "name": "shoubao wang",
                "org": ""
            },
            {
                "name": "depei liu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "Biochemical and Biophysical Research Communications",
        "year": 2013
    },
    "xjedoIX6": {
        "id": "xjedoIX6",
        "title": "The flavonoid apigenin protects brain neurovascular coupling against amyloid-β 25-35-induced toxicity in mice",
        "abstract": "Apigenin, one of the most common flavonoids, has demonstrated anti-inflammatory, anticarcinogenic, and free radical-scavenging activities. Recent studies revealed its protective effects against amyloid-β (Aβ)-induced neurotoxicity, but the mechanism was unclear. In the present study, we aimed to explore the anti-amnesic and protective effects of apigenin against Aβ 25-35-induced toxicity and the underlying mechanisms in the cerebral cortex in mice. The learning and memory impairments, changes in morphology of major components of neurovascular unit, ultrastructural changes and oxidative stress of cerebral cortex, cerebrovascular dysfunction, and neuronal changes were detected after oral administration of apigenin continuously for 8 days. Our results demonstrate that oral administration of apigenin for Aβ 25-35-induced amnesic mice conferred robust neurovascular coupling protection, involving improvement of the learning and memory capabilities, maintenance of neurovascular unit integrity, modulation of microvascular function, reduction of neurovascular oxidative damage, increase of regional cerebral blood flow, improvement of cholinergic system involving the inhibition of AChE activity and elevation of ACh level, and modification of BNDF, TrkB, and phospho-CREB levels. © 2011 - IOS Press and the authors. All rights reserved.",
        "keywords": [
            "Amyloid-β peptide",
            "apigenin",
            "blood-brain barrier",
            "neurovascular unit"
        ],
        "authors": [
            {
                "name": "Rui Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Haiguang Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xi Lan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Jian Ying",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of Alzheimer's Disease",
        "year": 2011
    },
    "6UK2ZV7n": {
        "id": "6UK2ZV7n",
        "title": "DL0410 can reverse cognitive impairment, synaptic loss and reduce plaque load in APP/PS1 transgenic mice.",
        "abstract": "Cholinesterase inhibitors are first-line therapy for Alzheimer's disease (AD). DL0410 is an AChE/BuChE dual inhibitor with a novel new structural scaffold. It has been demonstrated that DL0410 could improve memory deficits in both Aβ1-42-induced and scopolamine-induced amnesia in mice. In the present study, the therapeutic effect of DL0410 and its action mechanism were investigated in APP/PS1 transgenic mice. Six-month old APP/PS1 transgenic mice were orally administered with DL0410 (3, 10, 30mg/kg/day). After 60days, several behavioural tests, including the Morris water maze and step-down tests, were used to investigate the effects of DL0410 on mice behaviours. All the behavioural experimental results showed that DL0410 significantly ameliorated memory deficits. Meanwhile, DL0410 attenuated neural cell damage and reduced senile plaques significantly in the hippocampus of APP/PS1 transgenic mice. In addition, DL0410 significantly decreased Aβ plaques, while increasing the number of synapses and the thickness of PSD in the hippocampus. We also found DL0410 decreased the expression of APP, NMDAR1B and the phosphorylation level of NMDAR2B, and increased the phosphorylation level of CAMKII and the expression of PSD-95. In this study, the results of behavioural tests demonstrated for the first time that DL0410 could improve learning and memory dysfunction in APP/PS1 transgenic mice. The mechanism of its beneficial effects might be related to cholinesterase inhibition, Aβ plaques inhibition, improvement of synapse loss by regulating of expression of proteins related to synapses. As a result, DL0410 could be considered as a candidate drug for the therapy of AD.",
        "keywords": [
            "AD",
            "Aβ",
            "APP",
            "PS1",
            "PBS",
            "AChE",
            "BuChE",
            "ASCh",
            "BuSCh",
            "DTNB",
            "HRP",
            "MWM",
            "IHC",
            "NMDA",
            "NMDAR",
            "CAMKII",
            "PSD-95",
            "DL0410",
            "Alzheimer's disease",
            "Amyloid β",
            "Senile plaque",
            "Synapse",
            "Cholinesterase inhibitor"
        ],
        "authors": [
            {
                "name": "Ran-Yao Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Jining No. 1 People's Hospital in Shandong Province, Jining 272011, China."
            },
            {
                "name": "Gang Zhao",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Dong-Mei Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xiao-Cong Pang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Shou-Bao Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Jian-Song Fang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Chao Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Ai-Lin Liu",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China."
            },
            {
                "name": "Song Wu",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China."
            }
        ],
        "venue": "Pharmacology, biochemistry, and behavior",
        "year": 2015
    },
    "Uybtnlp7": {
        "id": "Uybtnlp7",
        "title": "Asymmetric dimethylarginine induces Vascular Smooth Muscle Cells migration via the activation of Rho/ROCK signal pathway",
        "abstract": "Background Endogenous nitric oxide synthase (NOS) inhibitor,asymmetric dimethylarginine (ADMA) has been positively related to initiation and progression of atherosclerotic cardiovascular disease.Rho and Rho-kinase/ROCK mediate phenotypic change and migration of vascular smooth muscle cells (VSMCs).Here,we tested the hypothesis that ADMA induces VSMC migration and phenotypic change via the activation of Rho/ROCK pathway.Methods and Findings ADMA activated the Rho/ROCK signal pathway by elevating RhoA activity and by stimulating phosphorylation of a ROCK substrate,regulatory myosin phosphatase targeting subunit (MYPT)-1.The migrating ability was induced in VSMC,which suggested the phenotypic changes from a differentiated type to a dedifferentiated type induced by ADMA.Blocking the Rho/ROCK signal way with the ROCK inhibitor Y27632,and elimination of ADMA via overexpression of human dimethylarginine dimethylaminohydrolase 2 (hDDAH2) and the precursor of NO,L-arginine all attenuated ADMA pathological effects on VSMC phenotypic changes.Morphological detection showed disassembly of actin cytoskeleton and focal adhesions (FAs) induced by ADMA,which further verify the phenotypic changes from differentiation to dedifferentiation while can be blocked by Y27632 and L-arginine.Conclusions ADMA activates Rho/ROCK signal transduction pathway and leads to the migration of VSMCs.Our study may help to provide novel insights into the therapy and prevention of atherosclerosis.",
        "keywords": [
            "Rho kinase/ROCK",
            "Vascular smooth muscle cells (VSMCs)",
            "Asymmetric dimethylarginine (ADMA)",
            "Phenotypic changes",
            "Migration"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College"
            },
            {
                "name": "Wenyu Xin",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College"
            },
            {
                "name": "yu Xin",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College"
            },
            {
                "name": "Xi La",
                "org": ""
            },
            {
                "name": "Chao Huang",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College"
            },
            {
                "name": "Zhao Rui",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College"
            },
            {
                "name": "Guanhua Du",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College"
            }
        ],
        "venue": "Molecular Cardiology of China",
        "year": 2012
    },
    "GxS3aegb": {
        "id": "GxS3aegb",
        "title": "Kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats.",
        "abstract": "Kaempferol has been reported to act as an anti-inflammation agent in LPS-induced neuroinflammation in vitro and in vivo, but its role in the inflammation after cerebral ischemia/reperfusion (I/R) is unclear. The present study was to investigate the effect of kaempferol on inflammation in ischemic brain tissue and explore its mechanisms in cerebral I/R rats. Cerebral I/R rat model was established by middle cerebral artery occlusion for 60 min and following reperfusion. Kaempferol at doses of 25, 50 and 100 mg/kg was administered for 7 days after cerebral I/R. Kaempferol treatment significantly reduced cerebral infarct volume, attenuated inflammation and blood-brain barrier (BBB) disruption after cerebral I/R, thus improved neurological outcomes at the day 7 after cerebral I/R. Furthermore, the results also showed kaempferol treatment decreased the phosphorylation and nuclear transposition of transcription factor NF-κB p65, thus inhibited expression of various pro-inflammatory proteins. In conclusion, kaempferol attenuates neuroinflammation and blood brain barrier dysfunction to improve neurological deficits in cerebral ischemia/reperfusion rats, its mechanism is related to NF-κB pathway.",
        "keywords": [
            "Cerebral ischemia/reperfusion (I/R)",
            "Cytokines",
            "Inflammation",
            "Microglial activation",
            "NF-κB pathway"
        ],
        "authors": [
            {
                "name": "Wei-Han Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xiao Cheng",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Ying-Lin Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Man Liu",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Shan-Shan Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yue-Hua Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: wangyuehua@pku.org.cn."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Brain research",
        "year": 2019
    },
    "cM0Gmmvp": {
        "id": "cM0Gmmvp",
        "title": "Network pharmacology: new guidelines for drug discovery]",
        "abstract": "The development of new drug is not only the main driving force for the development of pharmaceutical industry, but also plays a very important role in the social development. However, with the increasing demands, new drug development is facing great difficulties in recent years. The hypothesis of highly selective single-target is meeting the challenges because of its limitations. Network pharmacology has been one of the new strategies for new drug discovery based on single-target drug research in recent years. This paper focused on the basis of network pharmacology and its research progress, discussed its development direction and application prospects, and analyzed its limitations and problems as well. The application of network pharmacology in new drug development is discussed by comparing its guidelines with those of traditional Chinese medicine theory and Effective Components Group hypothesis of Chinese medicines.",
        "keywords": [
            "disease-drug network",
            "network pharmacology",
            "drug discovery",
            "network computational approach"
        ],
        "authors": [
            {
                "name": "Ai-lin Liu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2010
    },
    "1Ag7N2Oi": {
        "id": "1Ag7N2Oi",
        "title": "Dynamic Alterations of Brain Injury, Functional Recovery, and Metabolites Profile after Cerebral Ischemia/Reperfusion in Rats Contributes to Potential Biomarkers.",
        "abstract": "Cerebral ischemia-reperfusion (I/R) is characterized by initial transient cerebral ischemia followed by reperfusion. Various pathophysiological processes are involved in brain injury and functional recovery during cerebral I/R. There are few studies on dynamic metabolic process after cerebral I/R. The present study was to observe dynamic alteration of brain injury, functional recovery, and metabolites after cerebral I/R in rats and discover potential metabolic markers. The cerebral I/R model was established by middle cerebral artery occlusion (MCAO) for 90 min, following reperfusion in rats. The results of cerebral infarction area, cerebral edema, and behavior test showed that there were dynamic changes in brain injury and functional recovery at different periods after cerebral I/R. Further analysis showed that the brain injury was severe on the first day of cerebral I/R, and there was a significant functional recovery from the 7th day of cerebral I/R, followed by an aggravation trend of brain injury from the days 7 to 28. Furthermore, Matrix-assisted laser desorption ionization mass spectrometry imaging analysis showed that the expression of ATP, glucose, and citric acid on 7th day was the highest during cerebral I/R, which indicated that energy metabolism and oxidative phosphorylation played important roles during cerebral I/R. In addition, the untargeted metabolomic results showed that the level of isocitric acid, the ratio of oxyglutaric acid/glutamic acid, and the level of pyruvic acid associated with the TCA cycle were also the highest on the 7th day during cerebral I/R, which indicated that the transient spontaneous recovery of ischemic brain on the 7th day after ischemia-reperfusion might be related to oxidative phosphorylation and energy metabolism in the brain in this period. In conclusion, the results suggest that some small molecule metabolites participate in the brain injury and functional recovery during cerebral I/R, which is of great significance to the development of therapeutic drugs and diagnostic markers.",
        "keywords": [
            "Cerebral ischemia-reperfusion",
            " Stroke",
            " MALDI-MSI",
            " Untargeted metabolomics",
            " Metabolic marker"
        ],
        "authors": [
            {
                "name": "Xiao Cheng",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Ying-Lin Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Wei-Han Li",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Man Liu",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Shan-Shan Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Yue-Hua Wang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            }
        ],
        "venue": "Journal of Molecular Neuroscience",
        "year": 2020
    },
    "GqNB8EKo": {
        "id": "GqNB8EKo",
        "title": "A high-throughput fluorescent polarization model for screening EPO receptor ligand",
        "abstract": "Aim: To discover lead compound whose function is similar to EPO. Methods: A high-throughput Fluorescent Polarization (FP) assay was established for screening ligand of EPO receptor from small molescules and natural products. In the FP assay, EPO receptor was abstracted from FVA cell. EPO was labeled with FITC. Results: The optimized concentration of FITC-EPO was 10-9 mol · L-1. Different concentrations of DMSO (VDMSO/Vtotal: 0%, 0.5%, 1%, 2.5%, 5%) didn't affect the FP assay. The value of Z′ in the FP assay was 0.78. Conclusion: The assay was robust and of high sensitivity.",
        "keywords": [
            "EPO",
            "Fluorescent polarization",
            "High-throughput screening",
            "Z′ factor"
        ],
        "authors": [
            {
                "name": "WANG Jin-hua",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "HAN Guang-liang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "ZHANG Tian-tai",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2006
    },
    "SqGQFQeK": {
        "id": "SqGQFQeK",
        "title": "Determination and structure analysis of related substances of nitrofurantion enteric-coated tablets",
        "abstract": "Objective:To develop an HPLC method for the identification of 5-nitro furfural diacetate,nitrofurazone and substance A in nitrofurantion enteric-coated tablets,and to do structure analysis of common unknown substances by LC-ESI-MS.Methods:A phenomenex C18 column for 5-nitro furfural diacetate determination was adopted with a mobile phase consisting of phosphate buffer(adjusted to pH 4.5 with 6.8 g KH2PO4 added with 500 mL water)-acetonitrile(50∶50),and the detection wavelength was 306 nm.The mobile phase of nitrofurazone and substance A consisted of phosphate buffer(adjusted to pH 4.5 with 6.8 g KH2PO4added with 500 mL water)-acetonitrile(90∶10),and the detection wavelength was 365 nm.Results:The resolution and sensitivity of related substances were acceptable.The detected limit of 5-nitro furfural diacetate was 1.5 ng,and the detected limits of nitrofurazone and substance A were 0.08 ng and 0.14 ng respectively.Conclusion:The method of HPLC is sensitive,accurate and specific to be used to determinate the related substances in nitrofurantion tablets;Initial structure of related substance 1 was inferred by LC-ESI-MS.",
        "keywords": [
            "HPLC",
            "5-nitro furfural diacetate",
            "LC-ESI-MS",
            "hydrolysate impurity",
            "related substances",
            "nitrofurantion tablets",
            "nitrofurazone"
        ],
        "authors": [
            {
                "name": "XU Chang-gen",
                "org": "Shaanxi Institute for Food and Drug Control,Xi'an ,China"
            },
            {
                "name": "LIU Xiao-qin",
                "org": "Shaanxi Institute for Food and Drug Control,Xi'an ,China"
            },
            {
                "name": "WU Shao-ping",
                "org": "Shaanxi Institute for Food and Drug Control,Xi'an ,China"
            },
            {
                "name": "LIU Hai-jing",
                "org": "Shaanxi Institute for Food and Drug Control,Xi'an ,China"
            },
            {
                "name": "DING Li-xia",
                "org": "National Institutes for Food and Drug Control,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Pharmaceutical Analysis",
        "year": 2012
    },
    "jobVcQRj": {
        "id": "jobVcQRj",
        "title": "Targeting the neurovascular unit: Development of a new model and consideration for novel strategy fo",
        "abstract": "",
        "keywords": [
            "endothelial cell",
            "neuronal activity",
            "functional unit"
        ],
        "authors": [
            {
                "name": "rui liu",
                "org": ""
            },
            {
                "name": "tiantai zhang",
                "org": ""
            },
            {
                "name": "caixia wu",
                "org": ""
            },
            {
                "name": "xi lan",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "Fuel and Energy Abstracts",
        "year": 2011
    },
    "DYUBDpsE": {
        "id": "DYUBDpsE",
        "title": "Drug interaction potential of oral baicalein on metabolic enzymes in rats",
        "abstract": "Objective: To study the interaction potential of oral baicalein on main metabolic enzymes, including six hepatic CYP450 isoforms, GST and UGT. Methods: Hepatic microsomes and cytoplasm were prepared by a differential centrifugation method after oral administration of baicalein at 200 mg·kg-1 for 7 days in rats. Specific substrates were used as probes of six CYP450 isoforms to describe the activities of CYP450 isoforms. The activities of GST and UGT were detected by a colorimetric method. Results: Repeated dosing of baicalein showed a significant inhibition of CYP2C9, CYP2E1, GST and UGT in rats. The inhibition rates were 26.76%, 29.12%, 37.45% and 70.86% (P<0.05 or 0.01), respectively. No significant effects on the activities of CYP1A2, CYP2C19, CYP2D6 and CYP3A4 were observed. Conclusion: The inhibition of baicalein on several metabolic enzymes indicates that potential drug-drug interaction may occur when baicalein administered with other drugs.",
        "keywords": [
            "Baicalein",
            "Cytochrome P450 (CYP450)",
            "Drug-drug interaction",
            "Glutathione-S-transferase (GST)",
            "UDP-glucuronosyltransferase (UGT)"
        ],
        "authors": [
            {
                "name": "Shuo Tian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "HE Guo-rong",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Mei Gao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "SUN Jia-lin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "WANG Su-bo",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2012
    },
    "foUcU5Dl": {
        "id": "foUcU5Dl",
        "title": "GC and GC-MS rapid identification of total components and effective components in petroleum ether extracts of Xiaoxuming decoction",
        "abstract": "Objective:To identify the total components and effective components in petroleum ether extracts of Xi- aoxuming decoction.Methods:After the research on bioactivity effects,GC and GC-MS methods were used to i- dentify the effective fatty-dissolved components of Xiaoxuming decoction.Results:More than 100 components in petroleum ether extracts of Xiaoxuming decoction were separated and most of them were identified.The effective components were judged by their activity.Conclusion:With the identification of the total components and effective components,we can better ascertain the effective compounds and their action mechanism.",
        "keywords": [
            "Xiaoxuming decoction",
            "GC - MS",
            "traditional Chinese medicine compound prescriptions",
            "effective compound"
        ],
        "authors": [
            {
                "name": "LI Zhong-hong",
                "org": "China Pharmaceutical University,Nanjing ,China;Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "NI Kun-yi",
                "org": "China Pharmaceutical University,Nanjing ,China"
            },
            {
                "name": "LIAO Xue-wei",
                "org": "Analysis & Testing Center,Nanjing Normal University,Nanjing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Pharmaceutical Analysis",
        "year": 2006
    },
    "MF35TWjV": {
        "id": "MF35TWjV",
        "title": "Preparation of the Related Substances of Rivastigmine Tartrate",
        "abstract": "To perform the quality control of rivastigmine tartrate,eight related substances: 3-[(1S)-1-(dimethylamino-N-oxo)ethyl]phenyl ethylmethylcarbamate(3),3-[(1S)-1-(dimethylamino)ethyl]phenol N-oxide(4),3-vinylphenyl ethylmethylcarbamate(5),3-acetoxylacetophenone(6),3-acetylphenyl ethylmethylcarbamate(7),3-[(1S)-1-(dimethylamino)ethyl]phenyl dimethylcarbamate(8),3-[1-(dimethylamino)ethyl]phenyl ethylmethylcarbamate(9) and 3-[(1S)-1-(methylamino)ethyl]phenyl ethylmethylcarbamate(10) were synthesized.The chemical structures were confirmed by 1H NMR,13C NMR and HRMS.",
        "keywords": [
            "related substance",
            "rivastigmine",
            "synthesis"
        ],
        "authors": [
            {
                "name": "LI Jingya",
                "org": "State Key Lab.of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Lab.of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing "
            },
            {
                "name": "ZHOU Xingning",
                "org": "State Key Lab.of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Lab.of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing "
            },
            {
                "name": "WU Song",
                "org": "State Key Lab.of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Lab.of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing "
            },
            {
                "name": "DU Guanhua",
                "org": "State Key Lab.of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Lab.of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing "
            },
            {
                "name": "WANG Dongmei",
                "org": "State Key Lab.of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Lab.of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing "
            }
        ],
        "venue": "Chinese Journal of Pharmaceuticals",
        "year": 2013
    },
    "jQw62Zkw": {
        "id": "jQw62Zkw",
        "title": "Effects of the effective component group of Chinese herbal medicine Xiaoxuming Decoction on brain mitochondria in rats with chronic cerebral ischemia]",
        "abstract": "To investigate the effects of the effective component group of Xiaoxuming Decoction (XXM), a compound traditional Chinese herbal medicine, on cerebral mitochondria in rats with chronic cerebral ischemia.Rats were subjected to permanent bilateral common carotid artery occlusion to induce chronic cerebral ischemia. Then, the rats with chronic cerebral ischemia were randomly divided into five groups: model group, extract of Ginkgo biloba group and low-, medium- and high-dose effective component group of XXM groups. Another 11 rats without common carotid artery occlusion were used as a sham control. Gradient centrifugation was used to obtain the mitochondria from the rat brain. Clark oxygen electrode method was used to determine mitochondrial respiratory function. Photometric determination was used to measure mitochondrial swelling. Rodamine 123 was used to measure mitochondrial membrane potential. Western blotting was used to detect mitochondrial apoptosis.Compared with the sham group, the mitochondria dysfunction was caused by chronic cerebral ischemia associated with the decrease of oxidative phosphorylation parameters and the mitochondrial membrane potential, the increase of the mitochondrial degree, the elevation of reactive oxygen species level, the decrease in Bcl-2/Bax ratio, and the release of cytochrome c. The effective component group of XXM could reduce mitochondrial damage induced by chronic cerebral ischemia by improving the indexes mentioned above.The effective component group of Xiaoxuming Decoction can protect brain mitochondrial homeostasis and improve the function of mitochondria in rats with chronic cerebral ischemia, which may be the mechanism of its protection against chronic cerebral ischemia.",
        "keywords": [
            "mitochondria",
            "rats",
            "brain ischemia",
            "bcl-2-associated x protein",
            "plant extracts",
            "reactive oxygen species"
        ],
        "authors": [
            {
                "name": "Yue-hua Wang",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Xiao-li He",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Xiao-xiu Li",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Hai-lin Qin",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Guan-hua Du",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine",
        "year": 2012
    },
    "qEgFPEx3": {
        "id": "qEgFPEx3",
        "title": "Study on chemical constituents from roots of Saussurea lappa]",
        "abstract": "To study the chemical constituents in roots of Saussurea lappa.Isolation and purification were carried out by silica gel, Sephadex LH-20 and RP-18 column chromatography. The chemical structures of constituents were elucidated on the basis of spectral data.Eleven compounds were isolated and identified as: 5,7-dihydroxy-2-methylchromone (1), p-hydroxybenzaldehyde (2), 3,5-dimethoxy-4-hydroxy-benzaldehyde (3), 3,5-dimethoxy-4-hydroxy-acetophenone (4), ethyl 2-pyrrolidinone-5(s)-carboxylate (5), 5-hydroxymethyl-furaldehyde (6), palmitic acid (7), succinic acid (8), glucose (9), daucosterol (10), beta-sitosterol (11).Compounds 1, 2, 4, 5, 7, 9 were isolated from the genus Saussurea for the first time.",
        "keywords": [
            "Compositae",
            "Saussurea",
            "Saussurea lappa"
        ],
        "authors": [
            {
                "name": "Ting Zhang",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Hongqing Wang",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Ruoyun Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2009
    },
    "wqbPxTR6": {
        "id": "wqbPxTR6",
        "title": "Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model.",
        "abstract": "The treatment of acute ischemic stroke (AIS) using thrombolysis with recombinant tissue-plasminogen activator (rtPA, alteplase) is limited by its narrow time window and the risk of hemorrhage. Recombinant plasminogen activator (rPA, reteplase) has been used clinically on coronary artery thrombosis and acute myocardial infarction. It is necessary to induce strokes experimentally as a means of validating the rPA timing on patients with AIS. However, current embolic models cannot mimic clinical situations well due to the embolus's composition of dried blood clots or artificial materials. In this paper, we used two novel rat thromboembolic models to determine the dosage-effect relationship and therapeutic time window of r-PA. Male rats were administered rPA or rtPA intravenously at 2 to 12h postischemia. Cerebral blood flow, behavioral outcomes and infarct volume within the same animal group were determined. Our results demonstrated that rPA (0.2 and 0.4mg/kg) or rtPA (0.2mg/kg) restored focal perfusion, reduced cerebral infarction, and improved behavioral outcomes at 2 to 4h postischemia. rPA but not rtPA significantly restored focal perfusion at 6h postischemia. However, delayed rPA-treatment neither decreased infarct volume nor improved the neurological disorder. Cerebral hemorrhage occurred at 6h postischemia detected by Evan's blue leakage and tissue hemoglobin content. Collectively, Thrombolysis with rPA may be beneficial in revascularization at an acceptable dosage of 0.2 to 0.4mg/kg within 6h after the cerebral infarct onset.",
        "keywords": [
            "cerebral embolism",
            "rtPA",
            "stroke",
            "thrombolytic",
            "time window"
        ],
        "authors": [
            {
                "name": "Yinzhong Ma",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Li Li",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Ziran Niu",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Junke Song",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Yihuang Lin",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Huifang Zhang",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China."
            }
        ],
        "venue": "Pharmacological research",
        "year": 2016
    },
    "njLXek1S": {
        "id": "njLXek1S",
        "title": "Effect of different sizes of exogenous emboli on the cerebral injury in rats",
        "abstract": "Aim: To present the effect of different sizes of homologues exogenous emboli on the cerebral injury in rats. Methods: A 0.5 ml clot suspension with homologues blood emboli in three diameters (150-178 μm, 74-124 μm and 48-74 μm) or normal saline was injected to the right internal carotid artery of a rat. Relative regional cerebral blood flow (rCBF) was continuously monitored before and during the first 1 h following emboli injection. Neurological deficit and morphology of brain cortex were tested at 24 h after injection. Results: The rCBF was significantly decreased fewer than 30% at once after three sizes of emboli injection. Then, the rCBF increased at various degrees. At 1 h, the rCBF was up to 37.7% , 40.2% and 60.2%, respectively. Injection of different sizes of blood emboli in rats also significantly increased the neurological deficit scores to 2.55, 1.75 and 1.67 at 24 h after emboli injection, respectively. These results suggested that the bigger the emboli injected, the more decrease of rCBF and more increase of neurological deficit scores induced. HE staining revealed that rats injected with homologues blood emboli had multiple, widespread and sporadic injury in brain cortex but rats in N and NS groups had no injury. Conclusions: Injection of three sizes of emboli can lead to significant rCBF decrease, neurological deficit, and brain cortex injury. Basically, the decrease of rCBF and increase of nerurological deficit scores have positive correlation to the size of blood emboli.",
        "keywords": [
            "Brain cortex",
            "Different size of blood emboli",
            "Homologues",
            "Neurological deficit",
            "Rats",
            "rCBF"
        ],
        "authors": [
            {
                "name": "ZHANG Heng-ai",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Mei Gao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "SHI Li-li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "CHEN Bai-nian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "YU xiao-yan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2011
    },
    "ktOi3mrp": {
        "id": "ktOi3mrp",
        "title": "Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia.",
        "abstract": "A phytochemical investigation of root extracts of Salvia grandifolia led to isolation of six previously unreported diterpenoids, grandifolias A-F, along with eight known compounds. The structures of grandifolias A-F were primarily established by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Their absolute configurations were assigned by their calculated and experimental electronic circular dichroism spectra or by X-ray diffraction analysis. All of the diterpenoids were evaluated for their vasorelaxant effects. Grandifolia B and isograndifoliol both exhibited dose-dependent vasorelaxant effects on rat aortic rings, preconstricted by KCl or norepinephrine, with EC50 values of 36.36-74.51μg/mL.",
        "keywords": [
            "absolute configuration",
            "biological activity",
            "diterpenoid",
            "isolation",
            "labiatae",
            "salvia grandifolia",
            "structural elucidation",
            "vasorelaxant effect"
        ],
        "authors": [
            {
                "name": "Jie Kang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Li Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Dingding Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Hongqing Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Chao Liu",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Baoming Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Yu Yan",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Lianhua Fang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            },
            {
                "name": "Ruoyun Chen",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, No. 1 Xiannongtan Street, Beijing 100050, China."
            }
        ],
        "venue": "Phytochemistry",
        "year": 2015
    },
    "NzYiiPfm": {
        "id": "NzYiiPfm",
        "title": "Myocardial protection from ischemia-reperfusion injury by Salvianolic acid A in rats",
        "abstract": "Aim: To investigate the protective effect of Salvianolic acid A (SalA) on myocardial ischemia-reperfusion injury and the related mechanisms. Methods: Male Sprague Dawley rats were subjected to 10 min of ischemia induced by ligation of the left coronary artery and followed by 2h of reperfusion. 10 min before ischemia, SalA groups were given SalA (1.5 mg·kg -1, 0.5 mg·kg -1 respectively) by intravenous injection , control group received Lidocaine (5 mg·kg -1). The effect of SalA on ischemia-reperfusion induced arrhythmia in vivo was observed. We further investigated the effect of SalA on cultured primary neonatal rats cardiac myocytes exposed to hypoxia-reoxygenation. Results: Sal A (1.5 mg·kg -1) decreased the ischemic-reperfusion induced arrhythmia and reduced the blood CK and CK-MB levels. SalA had a protective effect on the hypoxia-reoxygenation injury in cardiac myocytes. SalA increased the intracelluar ATP production, and decreased the KCl-induced intracelluar Ca 2+ elevation and mitochondrial membrane potential. Conclusion: SalA has a protective effect on the myocardial injury induced by ischemia- reperfusion, which might be attributed to the antioxidant activity, the inhibition of calcium paradox, protection of mitochondrial function, and enhancement of the cardiac myocytes' ATP content.",
        "keywords": [
            "Cardiac arrhythmias",
            "Cardiac myocytes",
            "Hypoxia-reoxygenation",
            "Mitochondria",
            "Rats",
            "Reperfusion injury",
            "Salvianolic acid A"
        ],
        "authors": [
            {
                "name": "YANG Xiu-ying",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "QIANG Gui-fen",
                "org": "Aerospace Central Hospital(Aerospace Central Hospital),Beijing,China"
            },
            {
                "name": "Liping Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2011
    },
    "EaJTRfJd": {
        "id": "EaJTRfJd",
        "title": "Research progress of neuraminidase inhibitors for anti-influenza]",
        "abstract": "Influenza is a global contagious disease, which causes hundreds of thousands of people deaths. And new subtype of influenza may cause pandemic influenza, and lead to more serious consequence. Drugs for anti-influenza have played very important roles in influenza treatment and prevention, especially neuraminidase inhibitors are effective on both influenza A and B which have more safety and tolerance, therefore they have been widely used for influenza treatment. However, several viral drug-resistant cases have been reported. In this paper, the clinic therapy, prevention and drug resistance of neuraminidase inhibitors, including zanamivir, oseltamivir and peramivir, and progress in the research and development in our country are presented in order to promote research and development of new drugs for influenza treatment and prevention.",
        "keywords": [
            "drug resistance",
            "prophylaxis",
            "influenza",
            "clinical therapy",
            "neuraminidase inhibitor"
        ],
        "authors": [
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Hai-Di Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Fan Yang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2009
    },
    "PDfH52Rj": {
        "id": "PDfH52Rj",
        "title": "Effects of salvianolic scid A on plantar microcirculation and peripheral nerve function in diabetic rats.",
        "abstract": "Salvianolic acid A (SalA) is the main efficacious, water-soluble constituent of Salvia miltiorrhiza Bunge. This study evaluated the effects of SalA on plantar microcirculation and peripheral nerve dysfunction in streptozotocin (STZ )-induced type 2 diabetic rats. The rats were given a high-fat and high-sucrose diet for a month followed by intraperitoneal injection of STZ (30 mg/kg). Oral administration of SalA (1 and 3mg/kg, respectively) was performed daily for 10 weeks after modeling. Diabetic rats were given a high-fat diet, while age-matched healthy rats were given a standard chow. Plantar microcirculation was measured by Laser Doppler flowmetry, and peripheral nerve function was measured with regard to pain withdrawal latency and motor nerve conduction velocity. The results show that the plantar blood perfusion and vasodilation reactivities decreased significantly, and latency of pain withdrawal and motor nerve conduction velocity rose in diabetic rats compared with the normal control group. SalA increased peripheral blood perfusion and vascular activities; improved peripheral nerve function; and decreased AGEs levels, vascular eNOS expression, and blood glucose, lipid, vWF and malondialdehyde levels in diabetic rats. The beneficial effects of SalA on plantar microcirculation and peripheral nerve function in diabetic rats might be attributed to improvements in lipid and glucose metabolism in diabetic rats, the inhibition of AGEs formation and the development of oxidative stress-related nervous and vascular damage. Based on these findings, we proposed that therapeutic use of SalA to prevent the development of diabetic foot problems.",
        "keywords": [
            "diabetes",
            "microcirculation",
            "diabetic foot",
            "peripheral neuropathy",
            "salvianolic acid a",
            "water soluble",
            "laser doppler flowmetry",
            "glucose metabolism"
        ],
        "authors": [
            {
                "name": "Xiu-Ying Yang",
                "org": ""
            },
            {
                "name": "Lan Sun",
                "org": ""
            },
            {
                "name": "Pei Xu",
                "org": ""
            },
            {
                "name": "Li-Li Gong",
                "org": ""
            },
            {
                "name": "Gui-Fen Qiang",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2011
    },
    "fyc3rHxP": {
        "id": "fyc3rHxP",
        "title": "Neuroprotective and Cytotoxic Phthalides from Angelicae Sinensis Radix.",
        "abstract": "Seven phthalides, including a new dimeric one named tokinolide C (7), were isolated from Angelicae Sinensis Radix and characterized. The structures of these compounds were elucidated on the basis of comprehensive analysis of spectroscopic data and comparison with literature data. All of the compounds were evaluated for their cytotoxic activities against the A549, HCT-8, and HepG2 cancer cell lines. Riligustilide (4) showed cytotoxicity against three cancer cell lines, with IC50 values of 13.82, 6.79, and 7.92 μM, respectively. Tokinolide A (6) and tokinolide C (6) exerted low cytotoxicity in these cancer cell lines, while the remaining compounds were inactive. Flow cytometry analysis was employed to evaluate the possible mechanism of cytotoxic action of riligustilide (4). We observed that compound 4 was able to arrest the cell cycle in the G1, S phases and induce apoptosis in a time-dependent manner in HCT-8 cell lines. In addition, these compounds were evaluated for neuroprotective effect against SH-SY5Y cells injured by glutamate. The result showed that ligustilide (1), Z-butylidenephthalide (3) and tokinolide A (6) exhibited significant neuroprotective effects.",
        "keywords": [
            "Angelicae Sinensis Radix",
            "cytotoxicity activity",
            "flow cytometry",
            "neuroprotective effect",
            "phthalides"
        ],
        "authors": [
            {
                "name": "Wenxia Gong",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. 18835126271@163.com."
            },
            {
                "name": "Yuzhi Zhou",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. zhouyuzhi@sxu.edu.cn."
            },
            {
                "name": "Xiao Li",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. lixiaoedu@126.com."
            },
            {
                "name": "Xiaoxia Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. gaoxiaoxia@sxu.edu.cn."
            },
            {
                "name": "Junsheng Tian",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. jstian@sxu.edu.cn."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. qinxm@sxu.edu.cn."
            },
            {
                "name": "Guanhua Du",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No.92, Wucheng Road, Taiyuan 030006, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 0
    },
    "9fqMyQwR": {
        "id": "9fqMyQwR",
        "title": "Research of Determination Methods of Fluorouracil Injection",
        "abstract": "OBJECTIVE To confirm the best content determination method of fluorouracil injection.METHODS The contents of 95 batches of fluorouracil injection were determined by UV spectrophotometry absorption coefficient method and high performance liquid chromatography(HPLC),respectively.Through investigation of method recoveries,the reasons for difference in the content determination results were further analyzed.RESULTS The HPLC determination results were slightly higher than those of the UV method(P<0.05),The intervonversion of double alcohol type structure and double ketone type structure of fluorouracil might lead to the lower recovery and determination results of UV method.CONCLUSION The HPLC method is more accurate and reliable than UV method qualitatively and quantitatively.",
        "keywords": [
            "HPLC",
            "double ketone type structure",
            "fluorouracil injection",
            "double alcohol type",
            "UV spectrophotometry absorption coefficient method"
        ],
        "authors": [
            {
                "name": "WANG Chang-he",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "GUO Huan-ying",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "WU Pei-jia",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "XU Chang-gen",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "LIU Hai-jing",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "DING Li-xia",
                "org": "Chinese Pharmaceutical Association,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2013
    },
    "n5v59aEn": {
        "id": "n5v59aEn",
        "title": "Effect of Rhodiola n-butanol extract on the haemolysis induced by oxidant in vitro",
        "abstract": " Objective: To study the antioxidative effect and its mechanism of Rhodiola n-butanol extract.Method:Inhibition rates of liver microsome lipid peroxidation caused by FeSO_4/Cys were measured.Inhibition rates of haemolysis caused H_2O_2 were measured.DPPH free radical scavenging capacity was assayed.Result: Rhodiola nbutanol extracts can inhibit the liver microsome lipid peroxidation caused by FeSO_4/Cys,haemolysis caused H_2O_2.DPPH radical was scavenged by Rhodiola n-butanol extracts.Conclusion: Rhodiola has an antioxidative effect.",
        "keywords": [
            "Rhodiola herb",
            "fyee radicie",
            "haemolysis",
            "antioxidative"
        ],
        "authors": [
            {
                "name": "Sun Fangyun",
                "org": ""
            },
            {
                "name": "Wang Jinhua",
                "org": "Tibet National College Medicine Department,Xianyang "
            },
            {
                "name": "Zhang Bin",
                "org": "Tibet National College Medicine Department,Xianyang "
            },
            {
                "name": "Liang Zhi",
                "org": "Tibet National College Medicine Department,Xianyang "
            },
            {
                "name": "Qin Hailin",
                "org": "Tibet National College Medicine Department,Xianyang "
            },
            {
                "name": "Du Guanhua",
                "org": "Tibet National College Medicine Department,Xianyang "
            }
        ],
        "venue": "Pharmacology and Clinics of Chinese Materia Medica",
        "year": 2006
    },
    "oWJInxSV": {
        "id": "oWJInxSV",
        "title": "Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats.",
        "abstract": "A sensitive, specific and rapid LC-MS method was developed and validated for the determination of salvianolic acid D (SalD) in rat plasma. This method used a single quadrupole mass spectrometer with an electrospray ionization (ESI) source. A single ion monitoring scanning (SIM) mode was employed. It showed good linearity over the concentration range from 3.3 to 666.7 ng/mL for the determination of SalD. The R.S.D.% of intra-day and inter-day precision values were no more than 7.69%, and the accuracy was within 91%-104% at all quality control levels. This LC-MS method was applied to the pharmacokinetic study of SalD in rats. A two-compartmental model analysis was employed. The plasma concentrations at 2 min (C 2min) were 5756.06±719.61, 11,073.01±1783.46 and 21,077.58±5581.97 μg/L for 0.25, 0.5 and 1 mg/kg intravenous injection, respectively. The peak plasma concentration (C max) was 333.08±61.21 μg/L for 4 mg/kg oral administration. The area under curve (AUC0-t ) was 14,384.379±8443.184, 22,813.369±11,860.823, 46,406.122±27,592.645 and 8201.740±4711.961 μg/L·h for intravenous injection (0.25, 0.5 and 1 mg/kg) and oral administration (4 mg/kg), respectively. The bioavailability of SalD was calculated to be 4.159%±0.517%.",
        "keywords": [
            "AUC",
            " the area under curve",
            "Analysis method",
            "Bioavailability",
            "CI",
            " confidence interval",
            "CL",
            " clearance",
            "Cmax",
            " peak plasma concentration",
            "Danshen",
            "Dose proportionality",
            "ECE-1",
            " endothelin converting enzyme 1",
            "ESI",
            " electrospray ionization",
            "IS",
            " internal standard",
            "LC-MS",
            "LLOQ",
            " lower limit of quantification",
            "Pharmacokinetics",
            "QC",
            " quality control",
            "R.E.",
            " relative error",
            "R.S.D.",
            " relative standard deviation",
            "SIM",
            " single ion monitoring",
            "SalB",
            " salvianolic acid B",
            "SalD",
            " salvianolic acid D",
            "Salvia miltiorrhiza",
            "Salvianolic acid D",
            "TCM",
            " traditional Chinese medicine",
            "ULOQ",
            " upper limit of quantification"
        ],
        "authors": [
            {
                "name": "Junke Song",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Wen Zhang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Jialin Sun",
                "org": "Pharmacy Department of the Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China."
            },
            {
                "name": "Xiaona Xu",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xue Zhang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Li Zhang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Zhangying Feng",
                "org": "The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "Acta pharmaceutica Sinica. B",
        "year": 2015
    },
    "Z47X7pNX": {
        "id": "Z47X7pNX",
        "title": "Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis.",
        "abstract": "It is known that amyloid-β peptide (Aβ) plays a pivotal role in the pathogenesis of Alzheimer's disease (AD). Interaction between Aβ and the receptor for advanced glycation end products (RAGE) has been implicated in neuronal degeneration associated with this disease. Pinocembrin, a flavonoid abundant in propolis, has been reported to possess numerous biological activities beneficial to health. Our previous studies have demonstrated that pinocembrin has neuroprotective effects on ischemic and vascular dementia in animal models. It has been approved by the State Food and Drug Administration of China for clinical use in stroke patients. Against this background, we investigated the effects of pinocembrin on cognitive function and neuronal protection against Aβ-induced toxicity and explored its potential mechanism.Mice received an intracerebroventricular fusion of Aβ25-35. Pinocembrin was administrated orally at 20 mg/kg/day and 40 mg/kg/day for 8 days. Behavioral performance, cerebral cortex neuropil ultrastructure, neuronal degeneration and RAGE expression were assessed. Further, a RAGE-overexpressing cell model and an AD cell model were used for investigating the mechanisms of pinocembrin. The mechanisms underlying the efficacy of pinocembrin were conducted on target action, mitochondrial function and potential signal transduction using fluorescence-based multiparametric technologies on a high-content analysis platform.Our results showed that oral administration of pinocembrin improved cognitive function, preserved the ultrastructural neuropil and decreased neurodegeneration of the cerebral cortex in Aβ25-35-treated mice. Pinocembrin did not have a significant effect on inhibiting Aβ1-42 production and scavenging intracellular reactive oxygen species (ROS). However, pinocembrin significantly inhibited the upregulation of RAGE transcripts and protein expression both in vivo and in vitro, and also markedly depressed the activation of p38 mitogen-activated protein kinase (MAPK)-MAPKAP kinase-2 (MK2)-heat shock protein 27 (HSP27) and stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK)-c-Jun pathways and the downstream nuclear factor κB (NFκB) inflammatory response subsequent to Aβ-RAGE interaction. In addition, pinocembrin significantly alleviated mitochondrial dysfunction through improving mitochondrial membrane potential and inhibiting mitochondrial oxidative stress, and regulated mitochondrion-mediated apoptosis by restoration of B cell lymphoma 2 (Bcl-2) and cytochrome c and inactivation of caspase 3 and caspase 9.Pinocembrin was shown to infer cognitive improvement and neuronal protection in AD models. The mechanisms of action of the compound were illustrated on RAGE-dependent transduction inhibition and mitochondrion protection. It appears to be a promising candidate for the prevention and therapy of AD.",
        "keywords": [
            "amyloid-β peptide",
            "apoptosis",
            "pinocembrin",
            "receptor for advanced glycation end products",
            "alzheimer's disease",
            "gene expression profiling",
            "cognition",
            "signal transduction",
            "mitochondria",
            "alzheimer disease"
        ],
        "authors": [
            {
                "name": "Rui Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Cai-Xia Wu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dan Zhou",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fan Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shuo Tian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tian-Tai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "BMC medicine",
        "year": 2012
    },
    "RjoyaTIa": {
        "id": "RjoyaTIa",
        "title": "Evaluation of Chinese traditional patent medicines against influenza virus in vitro]",
        "abstract": "To study in vitro anti-influenza viral activities of Chinese traditional patent medicines for influenza prevention and treatment, neuraminidase (NA) activity assay was used to examine NA inhibitory activity of 33 Chinese traditional patent medicines through fluorimetric assay, and influenza virus induced cytopathic effect (CPE) inhibition assay was used to verify their anti-influenza viral activities in vitro. The assay results showed that most liquid preparations displayed relatively high NA inhibitory activities, such as Shuanghuanglian oral liquid, Qingkailing oral liquid, Qingre Jiedu oral liquid, and Reduning injection. Among liquid preparations, Shuanghuanglian oral liquid not only displayed the highest NA inhibitory effect, but also exhibited obvious in vitro anti-viral activity in CPE experiment. Among solid preparations, Shuanghuanglian powder for injection showed the highest activity on NA inhibition, and Fufang Yuxingcao tablet showed relatively strong anti-influenza viral activity in CPE cells. From the results, it can be concluded that most Chinese traditional patent medicines possessed NA inhibitory activity, but only a few of them displayed significant in vitro anti-influenza viral activities. These results will provide important information for the isolation of active constituents, and for the clinical uses of Chinese traditional patent medicines for influenza treatment and prevention.",
        "keywords": [
            "Chinese traditional patent medicine",
            "Cytopathic effect",
            "Influenza virus",
            "Neuraminidase"
        ],
        "authors": [
            {
                "name": "Mian Zu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"
            },
            {
                "name": "Dan Zhou",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"
            },
            {
                "name": "Li Gao",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"
            },
            {
                "name": "Ai-lin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing , China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2010
    },
    "nfAH1o8J": {
        "id": "nfAH1o8J",
        "title": "Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.",
        "abstract": "Insulin replacement therapy is a widely adopted treatment for all patients with type 1 diabetes and some with type 2 diabetes. However, injection of insulin has suffered from problems such as tissue irritation, abscesses, discomfort, and inconvenience. The use of orally bioactive insulin mimetics thus represents an ideal treatment alternative. Here we show that a chaetochromin derivative (4548-G05) acts as a new nonpeptidyl insulin mimetic. 4548-G05 selectively activates an insulin receptor (IR) but not insulin-like growth factor receptor-I or other receptor tyrosine kinases. Through binding to the extracellular domain of the IR, 4548-G05 induces activation of the receptor and initiates the downstream Akt and extracellular signal-related kinase pathways to trigger glucose uptake in C2C12 myotubes. Moreover, it displays a potent blood glucose-lowering effect when administrated orally in normal, type 1 diabetic, and type 2 diabetic mice models. Therefore, 4548-G05 may represent a novel pharmacological agent for antidiabetes drug development.",
        "keywords": [],
        "authors": [
            {
                "name": "Guifen Qiang",
                "org": "Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA."
            },
            {
                "name": "Shenghui Xue",
                "org": ""
            },
            {
                "name": "Jenny J Yang",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            },
            {
                "name": "Xiaobin Pang",
                "org": ""
            },
            {
                "name": "Xiaoting Li",
                "org": ""
            },
            {
                "name": "Devrishi Goswami",
                "org": ""
            },
            {
                "name": "Patrick R Griffin",
                "org": ""
            },
            {
                "name": "Eric A Ortlund",
                "org": ""
            },
            {
                "name": "Chi Bun Chan",
                "org": ""
            },
            {
                "name": "Keqiang Ye",
                "org": ""
            }
        ],
        "venue": "Diabetes",
        "year": 2014
    },
    "xgY4A5Y1": {
        "id": "xgY4A5Y1",
        "title": "Studies on the Antibacterial and Anti-inflammatory Actions of Danshen and Its Effects on the Immune System",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "li zhang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "fFbMHpmz": {
        "id": "fFbMHpmz",
        "title": "A drug target for Alzheimers disease: β-Secretase",
        "abstract": "Recent research suggests that the β-amyloid peptide (Aβ) is central to the pathophysiology of Alzheimers disease (AD). Amyloid plaques, primarily composed of Aβ, have significant neurotoxic effects. So it is therapeutic strategies for AD to lower the production of Aβ in the brain. Aβ is a product of catabolism of amyloid precursor protein (APP) by β-secretase and γ-secretase. BACE (β-secretase) exhibits all the properties of the β-secretase, and as the key rate-limiting enzyme that initiates the formation of Aβ, BACE is an attractive drug target for AD. The recent research of β-secretase is reviewed in this paper.",
        "keywords": [
            "β-Amyloid peptide",
            "βSecretase",
            "Alzheimers disease"
        ],
        "authors": [
            {
                "name": "Yuehua Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2003
    },
    "aQlaADWZ": {
        "id": "aQlaADWZ",
        "title": "Discovery of Influenza A virus neuraminidase inhibitors using support vector machine and Naïve Bayesian models",
        "abstract": "Abstract Neuraminidase (NA) is a critical enzyme in the life cycle of influenza virus, which is known as a successful paradigm in the design of anti-influenza agents. However, to date there are no classification models for the virtual screening of NA inhibitors. In this work, we built support vector machine and Naïve Bayesian models of NA inhibitors and non-inhibitors, with different ratios of active-to-inactive compounds in the training set and different molecular descriptors. Four models with sensitivity or Matthews correlation coefficients greater than 0.9 were chosen to predict the NA inhibitory activities of 15,600 compounds in our in-house database. We combined the results of four optimal models and selected 60 representative compounds to assess their NA inhibitory profiles in vitro. Nine NA inhibitors were identified, five of which were oseltamivir derivatives with large C-5 substituents exhibiting potent inhibition against H1N1 NA with \\(\\hbox {IC}_{50}\\) values in the range of 12.9–185.0 nM, and against H3N2 NA with \\(\\hbox {IC}_{50}\\) values between 18.9 and 366.1 nM. The other four active compounds belonged to novel scaffolds, with \\(\\hbox {IC}_{50}\\) values ranging 39.5–63.8 \\(\\upmu \\)M against H1N1 NA and 44.5–114.1 \\(\\upmu \\)M against H3N2 NA. This is the first time that classification models of NA inhibitors and non-inhibitors are built and their prediction results validated experimentally using in vitro assays.",
        "keywords": [
            "Influenza virus",
            "Neuraminidase inhibitor",
            "Support vector machine",
            "Naïve Bayesian",
            "Virtual screening",
            "H1N1",
            "H3N2",
            "SVM"
        ],
        "authors": [
            {
                "name": "Wenwen Lian",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People’s Republic of China"
            },
            {
                "name": "Jiansong Fang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People’s Republic of China"
            },
            {
                "name": "Chao Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People’s Republic of China"
            },
            {
                "name": "Xiaocong Pang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People’s Republic of China"
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People’s Republic of China ; Beijing Key Laboratory of Drug Target Research and Drug Screening, Beijing, 100050, People’s Republic of China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, 1 Xian Nong Tan Street, Beijing, 100050, People’s Republic of China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People’s Republic of China ; Beijing Key Laboratory of Drug Target Research and Drug Screening, Beijing, 100050, People’s Republic of China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, 1 Xian Nong Tan Street, Beijing, 100050, People’s Republic of China"
            }
        ],
        "venue": "Molecular Diversity",
        "year": 2015
    },
    "F1xciLdu": {
        "id": "F1xciLdu",
        "title": "SIRT1 acts as a modulator of neointima formation following vascular injury in mice.",
        "abstract": "Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events involved in the pathophysiology of vascular diseases. Sirtuin 1 (SIRT1), a class III histone deacetylase (HDAC), has been reported to have the function of antiatherosclerosis, but its role in neointima formation remains unknown.The present study was designed to investigate the role of SIRT1 in the regulation of neointima formation and to elucidate the underlying mechanisms.A decrease in SIRT1 expression was observed following carotid artery ligation. smooth muscle cell (SMC)-specific human SIRT1 transgenic (Tg) mice were generated. SIRT1 overexpression substantially inhibited neointima formation after carotid artery ligation or carotid artery wire injury. In the intima of injured carotid arteries, VSMC proliferation (proliferating cell nuclear antigen (PCNA)-positive cells) was significantly reduced. SIRT1 overexpression markedly inhibited VSMC proliferation and migration and induced cell cycle arrest at G1/S transition in vitro. Accordingly, SIRT1 overexpression decreased the induction of cyclin D1 and matrix metalloproteinase-9 (MMP-9) expression by treatment with serum and TNF-α, respectively, whereas RNAi knockdown of SIRT1 resulted in the opposite effect. Decreased cyclin D1 and MMP-9 expression/activity were also observed in injured carotid arteries from SMC-SIRT1 Tg mice. Furthermore, 2 targets of SIRT1, c-Fos and c-Jun, were involved in the downregulation of cyclin D1 and MMP-9 expression.Our findings demonstrate the inhibitory effect of SIRT1 on the VSMC proliferation and migration that underlie neointima formation and implicate SIRT1 as a potential target for intervention in vascular diseases.",
        "keywords": [
            "sirt1",
            "neointima formation",
            "proliferation",
            "migration",
            "vascular smooth muscle cells"
        ],
        "authors": [
            {
                "name": "Li Li",
                "org": "National Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, No 5 Dong Dan San Tiao, Beijing 100005, People's Republic of China."
            },
            {
                "name": "Hui-Na Zhang",
                "org": ""
            },
            {
                "name": "Hou-Zao Chen",
                "org": ""
            },
            {
                "name": "Peng Gao",
                "org": ""
            },
            {
                "name": "Li-Hua Zhu",
                "org": ""
            },
            {
                "name": "Hong-Liang Li",
                "org": ""
            },
            {
                "name": "Xiang Lv",
                "org": ""
            },
            {
                "name": "Qing-Jun Zhang",
                "org": ""
            },
            {
                "name": "Ran Zhang",
                "org": ""
            },
            {
                "name": "Zhao Wang",
                "org": ""
            },
            {
                "name": "Zhi-Gang She",
                "org": ""
            },
            {
                "name": "Ran Zhang",
                "org": ""
            },
            {
                "name": "Yu-Sheng Wei",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            },
            {
                "name": "De-Pei Liu",
                "org": ""
            },
            {
                "name": "Chih-Chuan Liang",
                "org": ""
            }
        ],
        "venue": "Circulation research",
        "year": 2011
    },
    "2OtPa2hX": {
        "id": "2OtPa2hX",
        "title": "A novel embolic middle cerebral artery occlusion model induced by thrombus formed in common carotid artery in rat.",
        "abstract": "Stroke is a major cause of death and disability worldwide. However, treatment options to date are very limited. To meet the need for validating the novel therapeutic approaches and understanding the physiopathology of the ischemic brain injury, experimental stroke models were critical for preclinical research. However, commonly used embolic stroke models are reluctant to mimic the clinical situation and not suitable for thrombolytic timing studies. In this paper, we established a standard method for producing a rat embolic stroke model with autologous thrombus formed within the common carotid artery (CCA) by constant galvanic stimulation. Then the thrombus was shattered and channeled into the origin of the MCA and small (lacunar) artery. To identify the success of MCA occlusion, regional cerebral blood flow was monitored, neurological deficits and infarct volumes were measured at 2, 4 and 6h postischemia. This model developed a predictable infarct volume (38.37±2.88%) and gradually reduced blood flow (20% of preischemic baselines) within the middle cerebral artery (MCA) territory. The thrombus occluded in the MCA was able to be lysed by a tissue-type plasminogen activator (t-PA) within 4h postischemia. The techniques presented in this paper would help investigators to overcome technical problems for stroke research.",
        "keywords": [
            "Cerebral embolism",
            "Disease model",
            "Stroke",
            "Therapeutic time window",
            "Thrombolytic",
            "t-PA"
        ],
        "authors": [
            {
                "name": "Yin-Zhong Ma",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Li Li",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Jun-Ke Song",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Zi-Ran Niu",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Hai-Feng Liu",
                "org": "Shandong Ehua Biopharmaceutical Co., Ltd., Shandong 252201, China; Shandong Dong-e E-Jiao Co., Ltd., Shandong 252201, China."
            },
            {
                "name": "Xiang-Shan Zhou",
                "org": "Shandong Dong-e E-Jiao Co., Ltd., Shandong 252201, China."
            },
            {
                "name": "Fu-Sheng Xie",
                "org": "Shandong Ehua Biopharmaceutical Co., Ltd., Shandong 252201, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "Journal of the neurological sciences",
        "year": 2015
    },
    "VgAOIz8K": {
        "id": "VgAOIz8K",
        "title": "In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum.",
        "abstract": "The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D 6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC(50) values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC(50) values were 0.040 and 5.54 µg/mL, respectively.",
        "keywords": [
            "gnetaceae",
            "gnetum pendulum",
            "neuraminidase",
            "influenza virus",
            "stilbenoid",
            "sialidase",
            "enzymes",
            "in vitro",
            "enzyme activity"
        ],
        "authors": [
            {
                "name": "Ai-Lin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fan Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Mian Zhu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dan Zhou",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Mao Lin",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Simon Ming-Yuen Lee",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Yi-Tao Wang",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Planta medica",
        "year": 2010
    },
    "aJSqbzQv": {
        "id": "aJSqbzQv",
        "title": "Formononetin inhibits Vascular Smooth Muscle Cells migration and proliferation induced by PDGF-BB",
        "abstract": "Objective To investigate the effect of formononetin on the proliferation and the migrating activity of vascular smooth muscle cells(VSMCs) induced by Platelet-derived growth factor BB (PDGF-BB). Methods The effect of formononetin on the proliferation of VSMCs induced by PDGF-BB.was investigated by using crystal staining and BrdU incorporation assay. The effect of formononetin on the migrating activity of VSMCs induced by PDGF-BB by using wound healing assay. Western Blotting was used to detect the phosphorylation level of PDGFR. Results Formononetin inhibits PDGF-BB induced VSMC proliferation and migration in the concentration range from 0.3 to 10 μM. The inhibition of SalA on VSMC proliferation and migration is associated with the inhibition of phosphorylation of PDGFR. Conclusion Our results suggest that Formononetin inhibits migration and proliferation of VSMCs induced by PDGF-BB via the inhibition of the PDGFRβ phosphorylation.",
        "keywords": [
            "Proliferaion",
            "Vascular Smooth Muscle Cells (VSMCs)",
            "PDGF-BB",
            "Formononetin",
            "Migration"
        ],
        "authors": [
            {
                "name": "SUN Lan",
                "org": ""
            },
            {
                "name": "ZhAO Rui",
                "org": ""
            },
            {
                "name": "XIN Wen-yu",
                "org": ""
            },
            {
                "name": "LAN Xi",
                "org": ""
            },
            {
                "name": "HUANG Chao",
                "org": ""
            },
            {
                "name": "DU Guan-hua",
                "org": ""
            }
        ],
        "venue": "Molecular Cardiology of China",
        "year": 2012
    },
    "d4Hrxsyc": {
        "id": "d4Hrxsyc",
        "title": "HPLC–MS and HPLC–MS/MS analysis of seven active constituents of Xiao-Xu-Ming decoction and application to a pharmacokinetic study after oral administration to rat",
        "abstract": "",
        "keywords": [
            "pharmacokinetics"
        ],
        "authors": [
            {
                "name": "yilin wang",
                "org": ""
            },
            {
                "name": "chunguang ding",
                "org": ""
            },
            {
                "name": "caisheng wu",
                "org": ""
            },
            {
                "name": "kehe du",
                "org": ""
            },
            {
                "name": "jinlan zhang",
                "org": ""
            },
            {
                "name": "hailin qin",
                "org": ""
            },
            {
                "name": "jinfeng hou",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "tj6uI4rK": {
        "id": "tj6uI4rK",
        "title": "Rho kinase inhibition activity of pinocembrin in rat aortic rings contracted by angiotensin II.",
        "abstract": "AIM: To investigate the effects of pinocembrin on angiotensin II (Ang II)-induced vascular contraction, and to explore its molecular mechanism of actions. METHODS: The isometric vascular tone was measured in rat thoracic aortic rings with denuded endothelium. Phosphorylation level of myosin phosphatase target unit 1 (MYPT1), and protein levels of Rho kinase 1 (ROCK1, ROKβ or p160ROCK) and angiotensin II type-1 receptor (AT 1 R) were determined by Western blot analysis. RESULTS: Pinocembrin produced a relaxant effect on endothelium-denuded aortic rings contracted by Ang II (100 nmol·L -1 ) in a dose-dependent manner. In endo-thelium-denuded aortic rings stimulated by Ang II, pretreatment with pinocembrin (25 and 100 μmol·L -1 ) for 20 min significantly attenuated MYPT1 phosphorylation and ROCK1 protein levels. Meanwhile, the protein level of AT 1 R in response to Ang II was not affected by pinocembrin in rat aortic rings. CONCLUSION: These findings indicate that pinocembrin inhibits vasoconstriction induced by Ang II in rat endothelium-denuded aortic rings, and the mechanism at least in part, is due to the blockade of the RhoA/ROCK pathway.",
        "keywords": [
            "pinocembrin",
            "mypt1",
            "angiotensin ii",
            "at1r",
            "rho kinase"
        ],
        "authors": [
            {
                "name": "Li Li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hai-Guang Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tian-Yi Yuan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yan Zhao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese journal of natural medicines",
        "year": 2013
    },
    "uKglCZY7": {
        "id": "uKglCZY7",
        "title": "Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors.",
        "abstract": "Rho-kinase inhibitors are effective candidates for the treatment of neural and cardiovascular disorders. The present paper reports the discovery of a novel class of ROCK-I inhibitors by integrating virtual screening with high-throughput screening methods. We developed common-feature pharmacophore models based on known representative ROCK inhibitors and employed them to screen a database of 12,280 compounds. We then applied a LigandFit model to reduce the number of hits. A new high-throughput screening model based on Kinase-Glo Luminescent Kinase Assay was established to identify inhibitors observed among the virtual screening models. Ten hits were found to have larger than 70% inhibition at 10 micromol l(-1) and were worthy of further investigation.",
        "keywords": [
            "rho-kinase",
            "ligandfit",
            "high-throughput screening",
            "pharmacophore",
            "virtual screening",
            "rho kinase",
            "high throughput screening"
        ],
        "authors": [
            {
                "name": "Li-Li Gong",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": ""
            },
            {
                "name": "Jian-Hao Peng",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Journal of biotechnology",
        "year": 2010
    },
    "BJgg4J50": {
        "id": "BJgg4J50",
        "title": "Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue.",
        "abstract": "Our comprehensive lipidomics and transcriptomics analyses revealed differences in lipid composition and lipid metabolism of two depot-specific WAT, which would offer new insights into the investigation of heterogeneity of visceral and subcutaneous white adipose tissue.",
        "keywords": [
            "Lipidomics",
            "Subcutaneous adipose tissue",
            "Transcriptomics",
            "Visceral adipose tissue",
            "White adipose tissue heterogeneity"
        ],
        "authors": [
            {
                "name": "Biyu Hou",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China."
            },
            {
                "name": "Yan Zhao",
                "org": "Qingdao Municipal Hospital, Qingdao 266011, China."
            },
            {
                "name": "Ping He",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China."
            },
            {
                "name": "Chunyang Xu",
                "org": "Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China."
            },
            {
                "name": "Peng Ma",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China."
            },
            {
                "name": "Sin Man Lam",
                "org": "Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China."
            },
            {
                "name": "Bowen Li",
                "org": "LipidALL Technologies Ltd., Changzhou, China."
            },
            {
                "name": "Victoria Gil",
                "org": "Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, 60612, IL, USA."
            },
            {
                "name": "Guanghou Shui",
                "org": "Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China."
            },
            {
                "name": "Guifen Qiang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China. Electronic address: qianggf@imm.ac.cn."
            },
            {
                "name": "Chong Wee Liew",
                "org": "Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, 60612, IL, USA. Electronic address: cwliew@uic.edu."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Life sciences",
        "year": 2020
    },
    "29jMwL4e": {
        "id": "29jMwL4e",
        "title": "EETs mediate cardioprotection of salvianolic acids through MAPK signaling pathway",
        "abstract": "",
        "keywords": [
            "acute myocardial infarction",
            "mapk"
        ],
        "authors": [
            {
                "name": "shoubao wang",
                "org": ""
            },
            {
                "name": "weiku zhang",
                "org": ""
            },
            {
                "name": "xiaobin pang",
                "org": ""
            },
            {
                "name": "li li",
                "org": ""
            },
            {
                "name": "guorong he",
                "org": ""
            },
            {
                "name": "xiuying yang",
                "org": ""
            },
            {
                "name": "lianhua fang",
                "org": ""
            },
            {
                "name": "juntian zhang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "h8qkNknV": {
        "id": "h8qkNknV",
        "title": "Vasorelaxant effect of euxanthone in the rat thoracic aorta.",
        "abstract": "This study was undertaken to investigate the effect of euxanthone on isolated rat thoracic aorta. Euxanthone concentration-dependently relaxed high K+-induced sustained contractions with IC50 values of 32.28+/-1.73 microM and this inhibition was antagonized by increasing the Ca2+ concentration in the medium. These results indicated that euxanthone may have calcium antagonistic property. Euxanthone also relaxed norepinephrine (NE)-induced sustained contractions with IC50 values of 32.50+/-2.15 microM and this relaxant effect was unaffected by the removal of endothelium or by the presence of propranolol, indomethacin, glibenclamide or N(omega)-nitro-L-arginine. Moreover, euxanthone inhibited both the phasic and tonic contractions induced by NE in a concentration-dependent manner and showed more potent inhibition on phasic contraction (P < 0.01). Pre-treatment with euxanthone inhibited vascular contraction induced by phorbol 12, 13-dibutyrate (PDBu), a protein kinase C (PKC) agonist, in either the presence or absence of Ca2+ in the solution with IC50 values of 20.15+/-1.56 and 18.30+/-1.62 microM, respectively. However, when the tissues were treated with euxanthone after the PDBu-induced contraction had reached a steady state, the tension was not affected by euxanthone. This study also showed that the inhibitory effect of pre-treatment of euxanthone was more potent than the post-treatment after the tension had reached a steady state. These results suggested that the vasorelaxation of euxanthone may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway besides the direct inhibition of calcium influx and its vasorelaxant effect is more active on calcium-independent pathway and more sensitive to the initial stage of contraction.",
        "keywords": [
            "aorta",
            "euxanthone",
            "protein kinase c",
            "calcium",
            "vasorelaxation",
            "steady state",
            "signaling pathway"
        ],
        "authors": [
            {
                "name": "Lian-Hua Fang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Ya-Mei Mu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Li-Lin Lin",
                "org": "Institute of Medical Botany, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Pei-Gen Xiao",
                "org": "Institute of Medical Botany, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Vascular pharmacology",
        "year": 2006
    },
    "ggYqThc2": {
        "id": "ggYqThc2",
        "title": "Pathological Mechanism Research in Chronic Unpredictable Mild Stress of Rats",
        "abstract": "Depression is a psychological disorder characterized by behavioral,neurochemical and other physiological abnormities.Chronic exposure to mild unpredictable stress(CUMS) has previously been found to cause an antidepressant-reversible decrease in the consumption of palatable sweet solutions,at the same time biochemical disturbances induced by the CUMS procedure were similar to those found in human depression.We review the pathological changes of the animal model of depression(CUMS).it reflected in some persistent molecular pathologys,such as the changes in receptor,signal transduction.",
        "keywords": [
            "Pathological changes",
            "CUMS",
            "Receptor",
            "Signal transduction"
        ],
        "authors": [
            {
                "name": "ZHAO Rui",
                "org": "Chinese Academy of Medical Sciences & Peking Union Medical College%%#PUMC%%#,Institute of Materia Medica%%#IMM%%#, national center for pharmaceutical screening%%#NCPS%%#,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences & Peking Union Medical College%%#PUMC%%#,Institute of Materia Medica%%#IMM%%#, national center for pharmaceutical screening%%#NCPS%%#,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Comparative Medicine",
        "year": 2011
    },
    "1pfOPRUK": {
        "id": "1pfOPRUK",
        "title": "Comparison of Two Different Astragali Radix by a 1 H NMR-Based Metabolomic Approach",
        "abstract": "Astragali Radix (AR) is a commonly used herbal drug in traditional chinese medicine and is widely used for the treatment of diabetes, cardiovascular diseases, nephropathy, and neuropathy. The main source of AR in China is the dried root of Astragalus membranaceus var. mongholicus (Bge.) Hsiao, and both cultivated and wild ARs are used clinically. A systematic comparison of cultivated AR (GS-AR) and wild AR (SX-AR) should be performed to ensure the clinical efficacy and safety. In this study, the chemical composition of the two different ARs, which were collected in the Shanxi (wild) and Gansu (cultivated) provinces, were compared by NMR-based metabolic fingerprint coupled with multivariate analysis. The SX-AR- and GS-AR-induced metabolic changes in the endogenous metabolites in mice were also compared. The results showed that SX-AR and GS-AR differed significantly not only in the primary metabolites but also in the secondary metabolites. However, alterations among the endogenous metabolites in the serum, ...",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            },
            {
                "name": "ke li",
                "org": ""
            },
            {
                "name": "haifeng sun",
                "org": ""
            },
            {
                "name": "zhenyu li",
                "org": ""
            },
            {
                "name": "aiping li",
                "org": ""
            }
        ],
        "venue": "Journal of Proteome Research",
        "year": 2015
    },
    "k2cKsqDH": {
        "id": "k2cKsqDH",
        "title": "Progress in study of pharmacological effect of Cortex Fraxini]",
        "abstract": "Cortex Fraxini is a commonly used traditional Chinese medicine. It has been indicated that Cortex Fraxini possess various pharmacological effects, including anti-pathogenic microorganism, anti-inflammatory, analgesic, anti-cancer, anti-oxidative stress, neuroprotective and vascular protect effects. Cortex Fraxini has been therapeutically used in the treatment of inflammations, bacillary dysentery, relieving fever, relieving cough and asthma. This paper reviewed recent progress in the studies on pharmacological effects and clinical applications of Cortex Fraxini.",
        "keywords": [
            "fraxetin",
            "cortex fraxini",
            "raxin",
            "pharmacol ogical effects",
            "esculetin",
            "esculin"
        ],
        "authors": [
            {
                "name": "Lian-hua Fang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Yang Lv",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2008
    },
    "inla9Dnh": {
        "id": "inla9Dnh",
        "title": "Total flavonoids from Anchusa italica Retz. Improve cardiac function and attenuate cardiac remodeling post myocardial infarction in mice.",
        "abstract": "Our data suggest that TFAI exerts a potent protective effect against chronic MI injury, and its beneficial effects on cardiac function and cardiac remodeling might be attributable, at least in part, to anti-inflammation and inhibition of the PI3K/Akt/mTOR signaling pathway.",
        "keywords": [
            "Adverse remodeling",
            "Anchusa italica Retz.",
            "Cardiac function",
            "Myocardial infarction",
            "Total flavonoids"
        ],
        "authors": [
            {
                "name": "Shoubao Wang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: shoubaowang@imm.ac.cn."
            },
            {
                "name": "Yan Zhao",
                "org": "Qingdao Municipal Hospital, Qingdao, 266011, China. Electronic address: zhaoyan_1976@126.com."
            },
            {
                "name": "Junke Song",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: smilejunke@imm.ac.cn."
            },
            {
                "name": "Rongrong Wang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: wangrongrong@imm.ac.cn."
            },
            {
                "name": "Li Gao",
                "org": "China Key Laboratory of Traditional Uygur Medical Prescription, Xinjiang Uygur Autonomous Region Institute of Traditional Uygur Medicine, Urumqi, 830001, China. Electronic address: 83451908@qq.com."
            },
            {
                "name": "Li Zhang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: zhangli@imm.ac.cn."
            },
            {
                "name": "Lianhua Fang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: fanglh@imm.ac.cn."
            },
            {
                "name": "Yang Lu",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: luy@imm.ac.cn."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2020
    },
    "oLK4h0IV": {
        "id": "oLK4h0IV",
        "title": "The Effects of Danshen on Kidney Diseases",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin zhang",
                "org": "peking union medical college"
            },
            {
                "name": "tiantai zhang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "ucsNJFQk": {
        "id": "ucsNJFQk",
        "title": "Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease.",
        "abstract": "Polyphenols, which are naturally present in plants, have been studied for their chemical and pharmacological properties. Polyphenols have been found to exhibit various bioactivities such as antioxidant, free radical scavenging and anti-inflammatory effects, in addition to regulating the intracellular free calcium levels. These bioactivities are related to the underlying mechanisms of ischaemic heart diseases. Pharmacological studies have proven polyphenols to be effective in treating cardiovascular diseases in various ways, particularly ischaemic heart diseases. Based on their mode of action, we propose that some polyphenols can be developed as drugs to treat ischaemic heart diseases. For this purpose, a strategy to evaluate the therapeutic value of drugs for ischaemic heart diseases is needed. Despite several advances in percutaneous coronary intervention (PCI), the incidence of myocardial infarction and deaths due to cardiovascular diseases has not decreased markedly in China. Due to their pleiotropic properties and structural diversity, polyphenols have been of great interest in pharmacology. In the present review, we summarize the pharmacological effects and mechanisms of polyphenols reported after 2000, and we analyse the benefits or druggability of these compounds for ischaemic heart diseases.",
        "keywords": [
            "Flavonoids",
            "Ischaemic heart diseases",
            "Polyphenols"
        ],
        "authors": [
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Lan Sun",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Rui Zhao",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Lida Du",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Junke Song",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Li Zhang",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guorong He",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yongxiang Zhang",
                "org": "State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China."
            },
            {
                "name": "Juntian Zhang",
                "org": "Beijing Key Laboratory of drug target research and drug screening, State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "Pharmacology & therapeutics",
        "year": 2016
    },
    "ViDqSs0W": {
        "id": "ViDqSs0W",
        "title": "Optimization of expression condition of SARS-CoV PUPs genes in E. coli]",
        "abstract": "According to previous studies of SARS-CoV (Severe acute respiratory syndrome coronavirus), a variety of novel accessory genes have been identified in SARS-CoV genome, which were interspersed the structural genes of SARS-CoV and considered to be unique to the SARS-CoV genome. The predicted unknown proteins (PUPs) encoded by the accessory genes might play important roles in the SARS-CoV infection. Three of those genes, called X4, X5 and ORF10, were synthesized and introduced into E. coli to induce expression. SDS-PAGE and Western blotting revealed that the three genes have been expressed in E. coli. The induction of SARS PUPs genes expression in different temperatures, induction times, IPTG concentrations and A values of E. coli cells were performed. The optimal induction condition of SARS-CoV PUPs genes was characterized according to the orthorgonal analysis. The ratio of recombinant proteins of PUPs to total proteins is as follows: X4, 20%; X5, 27.8%; ORF10, 68.5% under the optimum conditions.",
        "keywords": [
            "E. coli",
            "Expression condition",
            "Optimization",
            "Predicted unknown protein",
            "SARS-CoV"
        ],
        "authors": [
            {
                "name": "Jian-Qiang Kong",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Wei Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Ping Zhu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Ke-Di Cheng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2007
    },
    "AUN5ktYw": {
        "id": "AUN5ktYw",
        "title": "Preparation and characterization a new certified reference material of puerarin (GBW09511)",
        "abstract": "Sample preparation, homogeneity study, stability study, value characterization, and evaluation of uncertainty of a new certified reference material (CRM) of puerarin are presented in this paper. The homogeneity was checked by a differential scanning calorimetry method. The stability was tested under different storage conditions. The CRM described above was homogeneous and stable at 25 degrees C for at least one year. The certified value of puerarin CRM is 99.66% with an extended uncertainty of 0.48% (k = 2). Coulometric titration and differential scanning calorimetry methods are used for purity determination of puerarin for the first time in this paper. The new CRM of puerarin can be used to validate analytical methods, improve the accuracy and comparability of measurement data, establish meteorological traceability of analytical results as well as control the quality of puerarin in relevant food and pharmaceutical formulations.",
        "keywords": [],
        "authors": [
            {
                "name": "ningbo gong",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Ctr Pharmaceut Polymorph, Beijing 100050, Peoples R China"
            },
            {
                "name": "yonghui guo",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Ctr Pharmaceut Polymorph, Beijing 100050, Peoples R China"
            },
            {
                "name": "ning yang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Ctr Pharmaceut Polymorph, Beijing 100050, Peoples R China"
            },
            {
                "name": "zhaolin gao",
                "org": "Key Lab Polymorph Pharmaceut ShanDong Prov, Tengzhou 277500, Peoples R China"
            },
            {
                "name": "guanhua du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Ctr Pharmaceut Polymorph, Beijing 100050, Peoples R China"
            },
            {
                "name": "yang lu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Ctr Pharmaceut Polymorph, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "ANALYTICAL METHODS",
        "year": 2012
    },
    "gQmA0kSv": {
        "id": "gQmA0kSv",
        "title": "Progress in the study of biological activities of Urotensin Ⅱ",
        "abstract": "Urotensin Ⅱ,a cycle peptide originally found from the fish,is the most potent vasoconstrictor.Urotensin Ⅱand its receptor have been found in central nerve system,cardiovascular system and other organs and tissues.It has been suggested that urotensin Ⅱplays important roles in the physiological and pathological procedures.Based on the evidences obtained from experiments,urotensin Ⅱmay become a new target for treating many diseases,particularly for cardiovascular diseases.",
        "keywords": [
            "urotensin Ⅱ",
            "myocardial remodeling",
            "urotensin Ⅱ receptor",
            "vasoconstrictor"
        ],
        "authors": [
            {
                "name": "ZHU Xiao-ming",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2006
    },
    "berjPhCg": {
        "id": "berjPhCg",
        "title": "Development of HTS model on SERT inhibitors combined biological screening model with HTVS]",
        "abstract": "In order to improve the efficiency of drug screening on serotonin transporter (SERT) inhibitors, a high-throughput screening (HTS) model is established in RBL-2H3 cells. The RBL-2H3 cells are very similar to the serotonin genetic neuro, in modulation of post-receptor mechanisms and transduction pathway of SERT reactivated. Depending on a fluorescence substrate ASP+ used in detection method of inhibitor rates, it's convenient, quick, accurate and effective, not making the environmental biohazard compared with radioactive experiments. Furthermore, biological screening model combined with computer aided virtual screening technique describing high-throughput virtual screening (HTVS). Bayesian classification method and molecular fingerprint similarity were applied to virtual screening technique, for screening compounds in compound library. Some compounds have been found, and then validated further by biological screening model. Combination of HTS and HTVS improves the efficiency of screening SERT inhibitors.",
        "keywords": [],
        "authors": [
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Jian-song Fang",
                "org": ""
            },
            {
                "name": "Ai-lin Liu",
                "org": ""
            },
            {
                "name": "Guan-hua Du",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2015
    },
    "nL83fLvY": {
        "id": "nL83fLvY",
        "title": "Targets and studies on anti-SARS drugs]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China. dugh@imm.ac.cn"
            },
            {
                "name": "Wei Wang",
                "org": ""
            },
            {
                "name": "Ke-di Cheng",
                "org": ""
            },
            {
                "name": "Li-li Cao",
                "org": ""
            },
            {
                "name": "Xiu-ying Yang",
                "org": ""
            },
            {
                "name": "Ping Zhu",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2004
    },
    "juxupHd5": {
        "id": "juxupHd5",
        "title": "Antioxidant Effect of Polygala fallax Hemsl",
        "abstract": "AIM: Polygala fallax Hemsl. is a widely-used folk medicine in China. Our work provides theoretical evidence for traditional application of Polygala fallax Hemsl. METHODS: Seven extracts were isolated from the root of Polygala fallax Hemsl., and were researched for the scavenging activity to DPPH, superoxide anions and hydroxy radical, and reducing effect on Fe~ 3+ in vitro. RESULTS:PFE3、 PFB4 had scavenging activity to DPPH, hydroxy radical and superoxide anions, with EC_ 50 : 92.44, 42.29,5.50;96.33, 38.26, 6.21 μg·mL~ -1 respectively. CONCLUSION: All extracts exert distinct antioxidant effects in vitro. It is suggested that traditional application of Polygala fallax Hemsl. in China may be related with its antioxidant activity.",
        "keywords": [
            "Antioxidant",
            "Free radical",
            "Polygala fallax Hemsl"
        ],
        "authors": [
            {
                "name": "HUANG Feng",
                "org": " , ~ 1 Institute of Materia Medica, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing ; ~ 2 Institute of medical plant, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing ,China"
            },
            {
                "name": "LIN Li-Lin",
                "org": " , ~ 1 Institute of Materia Medica, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing "
            },
            {
                "name": "HU Juan-Juan",
                "org": " , ~ 1 Institute of Materia Medica, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing "
            },
            {
                "name": "LIU Ai-Lin",
                "org": " , ~ 1 Institute of Materia Medica, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing "
            },
            {
                "name": "XIAO Pei-Gen",
                "org": " ~ 2 Institute of medical plant, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing ,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": " , ~ 1 Institute of Materia Medica, Chinese Academy of Medical Sciences /Peking Union Medical College, Beijing "
            }
        ],
        "venue": "Chinese Journal of Natural Medicines",
        "year": 2006
    },
    "JpuCa1kM": {
        "id": "JpuCa1kM",
        "title": "Establishment and Application of a High-Throughput Screening Assay for Xanthine Oxidase Inhibitor in Vitro",
        "abstract": "OBJECTIVE To establish a high-throughput assay for xanthine oxidase inhibitor screening.METHODS The activity of xanthine oxidase was assayed by ultraviolet spectrophotometry and the developed method was used to screen a set of 71 760 compounds in a high-throughput format. RESULTS The effective and reliable screening method was established.27 Compounds were identified from 71 760 compounds. The hits percent was 0.038% , among which 17 compounds were confirmed by subsequent test at multiple concentrations. The most potent compound showed an IC50of 93.7 nmol·L-1. CONCLUSION The highly efficient and sensitive high-throughput screening method can be successfully used to identify xanthine oxidase inhibitor and some high active compounds were discovered.",
        "keywords": [
            "High-throughput",
            "Screening model",
            "Xanthine oxidase"
        ],
        "authors": [
            {
                "name": "ZHU Shen-yin",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science, Beijing ,China;Department of Clinical Pharmacology,First Affiliated Hospital of Chongqing University of Medical Science, Chongqing ,China"
            },
            {
                "name": "ZHOU Yuan-da",
                "org": "Department of Clinical Pharmacology,First Affiliated Hospital of Chongqing University of Medical Science, Chongqing ,China"
            },
            {
                "name": "Qingshan Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science, Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2007
    },
    "Y6SYwYu4": {
        "id": "Y6SYwYu4",
        "title": "Effect of metformin on the formation of hepatic fibrosis in type 2 diabetic rats",
        "abstract": "The aim of this study is to investigate the effects of the metformin on the formation of hepatic fibrosis in type 2 diabetic rats and discuss its mechanism of liver-protecting activity. After SD rats were fed with high-fat and high-sucrose diet for four weeks, low-dose streptozotocin (STZ) was injected intraperitoneally to make the animal mode of type 2 diabetes. Then, all diabetic rats was fed with the high-fat diet and metformin (ig, 100 mg x kg(-1)) was given orally to metformin group for four months. After the last administration, fasting blood glucose was determined. The livers were removed to calculate the hepatic coefficient and to make HE and Picro acid-Sirius red staining, immunohistochemistry (alpha-SMA and TGFbeta1) and TUNEL staining in order to evaluate the effect of metformin on the hepatic fibrosis. The animal model of type 2 diabetes with hepatic fibrosis was successfully made. Metformin can significantly alleviate the lesions of hepatic steatosis and fibrosis, markedly reduce the expressions of alpha-SMA and TGFbeta1 in liver tissue of type 2 diabetic rats. However, TUNEL staining result suggested that metformin could not reduce apoptosis of hepatocytes. The results suggest that metformin can inhibit the formation of hepatic fibrosis in type 2 diabetes.",
        "keywords": [
            "Hepatic fibrosis",
            "Metformin",
            "Non-alcoholic fatty liver disease",
            "Type 2 diabetes"
        ],
        "authors": [
            {
                "name": "Gui-Fen Qiang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lijuan Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Qi Xuan",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiu-Ying Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li-Li Shi",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Heng-Ai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Bai-Nian Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2010
    },
    "LaWz3TEs": {
        "id": "LaWz3TEs",
        "title": "Preclinical pharmacokinetic evaluation and metabolites identification of methyl salicylate-2-O-β-d-lactoside in rats using LC-MS/MS and Q-TOF-MS methods.",
        "abstract": "Methyl salicylate-2-O-β-d-lactoside (MSL) is a natural salicylate derivative from the traditional Chinese medicine of Gaultheria yunnanensis (Franch.) Rehder (G. yunnanensis). As a non-steroidal anti-inflammatory drug (NSAID), MSL exerts a significant anti-arthritis effect but hardly has any gastrointestinal toxicity. In this paper, the pharmacokinetics, distribution, excretion and identification of MSL and its metabolites are described following rat oral and intravenous administration. The biological samples were quantified by UPLC-MS/MS and the metabolites in urine and feces were identified by using Q-TOF-MS. These results will support future investigations leading to clinical development of this drug.",
        "keywords": [
            "metabolites",
            "methylsalicylate-2-o-beta-d-lactoside",
            "pharmacokinetic",
            "tandem mass spectrometry"
        ],
        "authors": [
            {
                "name": "Dan Zhang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp;amp;Chinese Academy of Medical Sciences, Beijing 100050, China; Pharmacy Department, China-Japan Friendship Hospital, Beijing 100029, China."
            },
            {
                "name": "Chao Huang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp;amp;Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Wenyu Xin",
                "org": "Binzhou Medical University, Yantai 256603, China."
            },
            {
                "name": "Xiaowei Ma",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp;amp;Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Weiku Zhang",
                "org": "Department of Pharmacology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China."
            },
            {
                "name": "Tiantai Zhang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp;amp;Chinese Academy of Medical Sciences, Beijing 100050, China. "
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp;amp;Chinese Academy of Medical Sciences, Beijing 100050, China. "
            }
        ],
        "venue": "Journal of pharmaceutical and biomedical analysis",
        "year": 2015
    },
    "HmxKnA7C": {
        "id": "HmxKnA7C",
        "title": "Pharmacokinetics of methyl salicylate-2-O-β-D-lactoside, a novel salicylic acid analog isolated from Gaultheria yunnanensis, in dogs.",
        "abstract": "Methyl salicylate-2-O--D-lactoside (MSL), a natural salicylate derivative of Gaultheria yunnanensis (Franch.) Rehder (G. yunnanensis), has been shown to provide a beneficial anti-inflammatory effect in animal models. Studies on the pharmacokinetics and bioavailability of MSL can provide both a substantial foundation for understanding its mechanism and empirical evidence to support its use in clinical practice. A simple and sensitive high-performance liquid chromatography (HPLC) method, coupled with ultraviolet analyte detection, was developed for determining the concentration of MSL and its metabolite in beagle plasma. Chromatographic separation was achieved on a Agilent Zorbax SB-C-18 column (5 m,4.6x250 mm). The mobile phase consisted of aqueous solution containing 0.1% phosphoric acid and acetonitrile (82:90, v/v), at a flow rate of 1 mL/min. Validation of the assay demonstrated that the developed HPLC method was sensitive, accurate and selective for the determination of MSL and its metabolite in dog plasma. After orally administering three doses of MSL, it could no longer be detected in dog plasma and its metabolite, salicylic acid, was detected. Salicylic acid showed a single peak in the plasma concentration-time curves and linear pharmacokinetics following the three oral doses (r(2)>0.99). In contrast, only MSL was detected in plasma following intravenous administration. These results will aid in understanding the pharmacological significance of MSL. The developed method was successfully used for evaluation of the oral and intravenous pharmacokinetic profile of MSL in dogs. Copyright (c) 2013 John Wiley & Sons, Ltd.",
        "keywords": [
            "Gaultheria yunnanensis",
            "methyl salicylate-2-O--D-lactoside",
            "pharmacokinetics",
            "HPLC",
            "anti-inflammation"
        ],
        "authors": [
            {
                "name": "Dan Zhang",
                "org": "Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xiaowei Ma",
                "org": "Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Wenyu Xin",
                "org": "Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Chao Huang",
                "org": "Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Weiku Zhang",
                "org": "China Japan Friendship Hosp, Inst Clin Med Sci, Dept Pharmacol, Beijing 100029, Peoples R China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanhua Du",
                "org": "Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "BIOMEDICAL CHROMATOGRAPHY",
        "year": 2013
    },
    "HQy9c7xL": {
        "id": "HQy9c7xL",
        "title": "Development of a New Certified Reference Material of Kaempferol by Using Differential Scanning Calorimetry, Coulometric Titration Method, and Mass Balance Method",
        "abstract": "Dietary flavonols have been found to possess preventive and therapeutic potential against several kinds of cancers. According to epidemiologic investigation data, kaempferol is a major component of flavonols present in various natural sources such as herbs, vegetables, and fruits. The purity of kaempferol in candidate certified reference material (CRM) was based on the agreement of results obtained by three different methods, including differential scanning calorimetry (DSC), coulometric titration (CT), and mass balance method. The certified value of kaempferol CRM is 99.5 % with an expanded uncertainty of 0.2 % (k = 2). The new CRM of kaempferol can be used as a valuable tool to validate measurement methods, to evaluate analytical results, and to control the quality of kaempferol-related traditional herbs, foods, dietary supplements, and pharmaceutical formulations.",
        "keywords": [
            "Kaempferol",
            " Differential scanning calorimetry",
            " Coulometric titration",
            " Mass balance method",
            " Certified reference material"
        ],
        "authors": [
            {
                "name": "ningbo gong",
                "org": "academy of medical sciences united kingdom"
            },
            {
                "name": "guoshun zhang",
                "org": "academy of medical sciences united kingdom"
            },
            {
                "name": "baoxi zhang",
                "org": "academy of medical sciences united kingdom"
            },
            {
                "name": "guanhua du",
                "org": "academy of medical sciences united kingdom"
            },
            {
                "name": "zhaolin gao",
                "org": "Key Laboratory of Polymorph Pharmaceutical of Shandong Province,Tengzhou,China"
            },
            {
                "name": "yang lu",
                "org": "academy of medical sciences united kingdom"
            }
        ],
        "venue": "Food Analytical Methods",
        "year": 2015
    },
    "F9aDLNf9": {
        "id": "F9aDLNf9",
        "title": "Differential effects of Rho-kinase inhibitor and angiotensin II type-1 receptor antagonist on the vascular function in hypertensive rats induced by chronic l-NAME treatment",
        "abstract": "",
        "keywords": [
            "l"
        ],
        "authors": [
            {
                "name": "bainian chen",
                "org": ""
            },
            {
                "name": "lili shi",
                "org": ""
            },
            {
                "name": "xiaoyan yu",
                "org": ""
            },
            {
                "name": "jialin sun",
                "org": ""
            },
            {
                "name": "hengai zhang",
                "org": ""
            },
            {
                "name": "shoubao wang",
                "org": ""
            },
            {
                "name": "lianhua fang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "EOGxiIYv": {
        "id": "EOGxiIYv",
        "title": "Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile.",
        "abstract": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes the damage of dopaminergic neurons as seen in Parkinson's disease (PD). Oxidative stress has been implicated in the pathogenesis of PD. Baicalein, isolated from the traditional Chinese herbal medicine Huangqin (Scutellaria baicalensis Georgi), has been shown to have antioxidant effects. Here we investigated the effect of baicalein on MPTP-induced neurotoxicity in mice. Pretreatment with baicalein for a week was followed by challenge with MPTP for 4 consecutive days; the subsequent behavioral, biochemical and immunohistochemical manifestations in mice were determined and compared to those in untreated mice and mice challenged only with MPTP. The present study showed that baicalein could improve the abnormal behavior in MPTP-treated mice. The protective effect may be caused by increasing the levels of DA and 5-HT in the striatum, increasing the counts of dopaminergic neurons, inhibiting oxidative stress and the astroglia response. These results suggest that baicalein possesses potent neuroprotective activity and may be a potential anti-Parkinson's disease drug that is worthy of further study.",
        "keywords": [
            "neuroprotective",
            "baicalein",
            "2",
            "parkinson's disease",
            "3",
            "1-methyl-4-phenyl-1",
            "6-tetrahydropyridine"
        ],
        "authors": [
            {
                "name": "Yinxia Cheng",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guorong He",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Xin Mu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Xiaoxiu Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Juanjuan Hu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Bei Xu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Neuroscience letters",
        "year": 2008
    },
    "WzLYMHn4": {
        "id": "WzLYMHn4",
        "title": "Therapeutic strategies for stroke:targeting the neurovascular unit",
        "abstract": "Over the past two decades, researches have heavily emphasized on basic mechanisms of irreversible damage in brain cells after stroke. Many studies focused on what makes neurons die easily and what kind of strategies render neurons resistant to ischemic injury. In the past few years, clinical experience with clot-lysing drugs had confirmed expectations that early reperfusion improves clinical outcome. With recent research emphasizing methods to reduce tissue damage, both vascular and cell-based mechanisms, the spotlight is now shifting towards the study of how blood vessels and brain cells communicate with each other. The neurovascular unit (NVU) origins from an integrative blood vessel and neural system response in which all cellular and matrix elements involved in. The new research focus provides challenges and opportunities for research and therapy of stroke.",
        "keywords": [
            "stroke",
            "neurovascular unit",
            "blood brain barrier",
            "MMPs"
        ],
        "authors": [
            {
                "name": "GAO Mei",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "LIU Rui",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Clinical Pharmacology and Therapeutics",
        "year": 2008
    },
    "WivAZoU6": {
        "id": "WivAZoU6",
        "title": "Salvianolic Acid A, a Component of Salvia miltiorrhiza, Attenuates Endothelial-Mesenchymal Transition of HPAECs Induced by Hypoxia.",
        "abstract": "Salvianolic acid A (SAA), a polyphenols acid, is a bioactive ingredient from a traditional Chinese medicine called Dan shen (Salvia Miltiorrhiza Bunge). According to previous studies, it was shown to have various effects such as anti-oxidative stress, antidiabetic complications and antipulmonary hypertension. This study aimed to investigate the effect of SAA on pulmonary arterial endothelial-mesenchymal transition (EndoMT) induced by hypoxia and the underlying mechanisms. Primary cultured human pulmonary arterial endothelial cells (HPAECs) were exposed to 1% O-2 for 48 h with or without SAA treatment. SAA treatment improved the morphology of HPAECs and inhibited the cytoskeleton remodeling. A total of 3 mu M SAA reduced migration distances from 262.2 mu m to 198.4 mu m at 24 h and 344.8 mu m to 109.3 mu m at 48 h. It was observed that the production of ROS in cells was significantly reduced by the treatment of 3 mu M SAA. Meanwhile, SAA alleviated the loss of CD31 and slightly inhibited the expression of alpha-SMA. The mechanisms study shows that SAA treatment increased the phosphorylation levels of Smad1/5, but inhibited that of Smad2/3. Furthermore, SAA attenuated the phosphorylation levels of ERK and Cofilin, which were enhanced by hypoxia. Based on these results, our study indicated that SAA treatment can protect HPAECs from endoMT induced by hypoxia, which may perform via the inhibition on ROS production and further through the downstream effectors of BMPRs or TGF beta R including Smads, ERK and ROCK/cofilin pathways.",
        "keywords": [
            "Salvianolic Acid A",
            "Endothelial-Mesenchymal Transition",
            "HPAEC",
            "Hypoxia",
            "Smads Pathway"
        ],
        "authors": [
            {
                "name": "Tianyi Yuan",
                "org": "Chinese Acad Med Sci, Beijing Key Lab Drug Targets Identificat & Drug S, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Yucai Chen",
                "org": "Chinese Acad Med Sci, Beijing Key Lab Drug Targets Identificat & Drug S, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Huifang Zhang",
                "org": "Chinese Acad Med Sci, Beijing Key Lab Drug Targets Identificat & Drug S, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Lianhua Fang",
                "org": "Chinese Acad Med Sci, Beijing Key Lab Drug Targets Identificat & Drug S, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Acad Med Sci, Beijing Key Lab Drug Targets Identificat & Drug S, Inst Mat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "AMERICAN JOURNAL OF CHINESE MEDICINE",
        "year": 2017
    },
    "ZHCDG6W5": {
        "id": "ZHCDG6W5",
        "title": "Relationship between endoplasmic reticulum stress and cerebral ischemia reperfusion injury",
        "abstract": "Endoplasmic reticulum is the main site of protein synthesis,modification and transport.Endoplasmic reticulum stress(ERS)is defined as a situation of gathering misfolded and(or) unfolded protein in endoplasmic reticulum and the failure of Ca2+ homeostasis.Early ERS will induce unfolded protein response(UPR) which may be protective to cells.On the contrary,long-time strong ERS will induce cell apoptosis,even death.A growing number of studies have suggested that ERS induced neuronal apoptosis was involved in the injury of cerebral ischemia and reperfusion.This review mainly summarizes recently reported discoveries concerning ERS associated with cerebral ischemia and reperfusion,which may reveal novel insight into the basic and clinical research of stroke and provide new ideas for the drug discovery.",
        "keywords": [
            "inflammation",
            "signaling",
            "apoptosis",
            "reactive oxygen species",
            "cerebral ischemia reperfusion injury",
            "Ca2+",
            "endoplasmic reticulum stress"
        ],
        "authors": [
            {
                "name": "WU Cai-xia",
                "org": "School of Life Science and Biopharmaceutics,Shenyang Pharmaceutical University, Shenyang ,China;Shandong Medical College,Linyi Shangdong ,China"
            },
            {
                "name": "LIU Rui",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences, Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences, Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2013
    },
    "XOQHMyK8": {
        "id": "XOQHMyK8",
        "title": "Antidiabetic Effect and Mechanisms of Gemfibrozil in Experimental Diabetes Mellitus Rats",
        "abstract": "OBJECTIVE To investigate the antidiabetic effect of gemfibrozil (Gem) and its possible mechanisms in experimental type 2 diabetes mellitus (T2DM) of rat. METHODS Experimental model of diabetes mellitus was induced by intraperitoneally injection of streptozotocin (STZ) in rats after feeding high fat and sucrose food for 4 weeks. RESULTS After 8 week's oral-administration,the level of fasting blood glucose (FBG),serum concentration of triglyceride (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C) and nonesterified fatty acid (NEFA) were decreased significantly in Gem treated groups compared with T2DM model group. Superoxide dismutase (SOD) activity was increased significantly in Gem groups compared with T2DM model group and malondialdehyde (MDA) content was decreased significantly in Gem groups compared with T2DM model group. CONCLUSION Gem can not only decrease hyperlipidemia but also improve glycometabolism by decreasing FBG in T2DM rat.",
        "keywords": [
            "diabites mellitus",
            "streptozotocin",
            "gemfibrozil",
            "mechanisms",
            "oxidative stress"
        ],
        "authors": [
            {
                "name": "FANG Lian-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "HU Juan-juan",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2009
    },
    "DWuTMjeY": {
        "id": "DWuTMjeY",
        "title": "High-throughput screening of human soluble epoxide hydrolase inhibitors]",
        "abstract": "To screen potential human soluble epoxide hydrolase (hsEH) inhibitors, a high-throughput screening model in 384-well microplate with total volume of 50 microL was established. Recombinant hsEH was cloned and expressed in E. coli. and its specific substrate PHOME was synthesized. The HTS model was based on fluorescence analysis with enhanced sensitivity and specificity (Z' = 0.65). A total of 47 360 samples (including 25 040 compounds and 22 320 natural products) were screened, of which 950 samples with inhibition greater than 80% were selected for further rescreening. Finally, two compounds with high inhibitory activity were identified, whose IC50 value were 8.56 and 4.31 micromol x L(-1), separately. The results indicated that the method was stable, sensitive, reproducible and also suitable for high-throughput screening.",
        "keywords": [
            "High-throughput screening",
            "Inhibitor",
            "Soluble epoxide hydrolase"
        ],
        "authors": [
            {
                "name": "Shou-Bao Wang",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Jing Guo",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Xiao-Ming Yu",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2010
    },
    "Yn1P3mRQ": {
        "id": "Yn1P3mRQ",
        "title": "Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats",
        "abstract": "The pharmacokinetic profile of gallocatechin-7-gallate (J10688) was studied in rats after intravenous administration. Male and female Sprague-Dawley (SD) rats received 1, 3, and 10 mg/kg (i.v.) of J10688 and plasma drug concentrations were determined by a high performance liquid chromatography-mass spectrometry (LC-MS) method. The pharmacokinetic software Data Analysis System (Version 3.0) was used to calculate the pharmacokinetic parameters. For different i.v. doses of J10688, the mean peak plasma concentration (C 0) values ranged from 11.26 to 50.82 mg/L, and mean area under the concentration-time curve (AUC0-t ) values ranged from 1.75 to 11.80 (mg·h/L). J10688 lacked dose-dependent pharmacokinetic properties within doses between 1 and 10 mg/kg, based on the power model. The method developed in this study was sensitive, precise, and stable. The pharmacokinetic properties of J10688 in SD rats were shown to have rapid distribution and clearance values. These pharmacokinetic results may contribute to an improved understanding of the pharmacological actions of J10688. ",
        "keywords": [
            "Dose proportionality",
            "Gallocatechin-7-gallate",
            "LC–MS",
            "Non-compartment model",
            "Pharmacokinetics"
        ],
        "authors": [
            {
                "name": "chao li",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "xiaowei song",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "junke song",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "xiaocong pang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "zhe wang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "ying zhao",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "wenwen lian",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "ailin liu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "guanhua du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "Acta pharmaceutica Sinica. B",
        "year": 2015
    },
    "p3SttX8U": {
        "id": "p3SttX8U",
        "title": "Characterization of a new anhydrous form of Rotundine and its monohydrate",
        "abstract": "",
        "keywords": [
            "bioavailability",
            "pxrd",
            "ir"
        ],
        "authors": [
            {
                "name": "shiying yang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "yang lu",
                "org": ""
            }
        ],
        "venue": "Journal of Molecular Structure",
        "year": 2015
    },
    "3TFctKoF": {
        "id": "3TFctKoF",
        "title": "SIRT1 upregulators from high-throughput screening as anti-proliferation and anti-migration agents in vascular smooth muscle cells (654.2)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "li li",
                "org": ""
            },
            {
                "name": "gang zhao",
                "org": ""
            },
            {
                "name": "haiguang yang",
                "org": ""
            },
            {
                "name": "qizhi cao",
                "org": ""
            },
            {
                "name": "peng gao",
                "org": ""
            },
            {
                "name": "houzao chen",
                "org": ""
            },
            {
                "name": "zhuqin zhang",
                "org": ""
            },
            {
                "name": "depei liu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2014
    },
    "t9bYfy7L": {
        "id": "t9bYfy7L",
        "title": "Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice.",
        "abstract": "Many studies of Parkinson's disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson's disease.",
        "keywords": [
            "1-Methyl-4-phenyl-1",
            "2",
            "3",
            "6-tetrahydropyridine",
            "Parkinson's disease",
            "Baicalein",
            "Antioxidant"
        ],
        "authors": [
            {
                "name": "Xin Mu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Xian Nong Tan Street, Beijing 100050, China"
            },
            {
                "name": "Guo-Rong He",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Xian Nong Tan Street, Beijing 100050, China"
            },
            {
                "name": "Xia Yuan",
                "org": "State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xue Yuan Road, Beijing 100191, China"
            },
            {
                "name": "Xiao-Xiu Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Xian Nong Tan Street, Beijing 100050, China"
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Pharmacology, biochemistry, and behavior",
        "year": 2011
    },
    "9VWqvKt2": {
        "id": "9VWqvKt2",
        "title": "Synthesis of 5,7-dihydroxyflavanone",
        "abstract": "An approach to the synthesis of 5,7-dihydroxyflavanone in media under Pd-C catalyst was described.The effects of reaction time,reaction temperature and amount of catalyst on the reaction were discussed.The optimized reaction conditions were:reaction temperature 53℃,reaction time 2h and catalyst 1.0g.The yield of the reaction was 83.26%.",
        "keywords": [
            "7-dihydroxyflavone",
            "5",
            "synthesis",
            "Pd-C",
            "7-dihydroxyflavanone"
        ],
        "authors": [
            {
                "name": "CHENG Yong-hao",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DUAN Ya-bo",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "QI Yan",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "GUO Xiao-yun",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "TONG Yuan-feng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "WU Song",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chemical Reagents",
        "year": 2006
    },
    "mGAWxZZZ": {
        "id": "mGAWxZZZ",
        "title": "CREB is activated in smooth muscle cells isolated from atherosclerotic plaques and reduces smooth muscle cell proliferation via p21-dependent mechanism.",
        "abstract": "",
        "keywords": [
            "atherosclerotic plaques",
            "carotid endarterectomy",
            "human aortic smooth muscle cells (hasmcs)",
            "camp response element-binding protein (creb)",
            "p21/cip1"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China."
            },
            {
                "name": "Rui Zhao",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; Beijing Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China."
            },
            {
                "name": "Yongyi Bai",
                "org": "Department of Geriatric Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China."
            },
            {
                "name": "Ruihua Cao",
                "org": "Department of Geriatric Cardiology, Chinese PLA General Hospital, No. 28, Fuxing Road, Beijing 100853, China."
            },
            {
                "name": "Fuyu Wang",
                "org": "Department of Neurosurgery, PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China."
            },
            {
                "name": "Shengqian Yang",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China."
            },
            {
                "name": "Zhizhen Qin",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "National Center for Pharmaceutical Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China; Beijing Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100050, China."
            }
        ],
        "venue": "International journal of cardiology",
        "year": 2014
    },
    "X73FbL9Q": {
        "id": "X73FbL9Q",
        "title": "In vitro evaluation on the antioxidant capacity of triethylchebulate, an aglycone from Terminalia chebula Retz fruit.",
        "abstract": "To evaluate the antioxidant and free-radical scavenging activities of triethylchebulate (TCL), an aglycone isolated from the fruit of Terminalia chebula Retz.Microsomes, mitochondria and red blood cells (RBCs) were isolated from rat liver. The antioxidant capacities were evaluated by determining the inhibitory effects of TCL on lipid peroxidation, hydrogen peroxide (H(2)O(2))-induced RBCs hemolysis and RBCs autoxidative hemolysis. The free-radical scavenging activities were evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and 2´,7´-dichlorodihydrofluorescin diacetate (DCFH(2)-DA) assay.TCL significantly inhibited FeSO(4)/Cys-induced microsomes lipid peroxidation and protected both H(2)O(2-)-induced RBCs hemolysis and RBCs auto-hemolysis in a dose-dependent manner. Furthermore, TCL demonstrated potent DPPH free-radical scavenging ability with IC(50) at 2.4×10(-5) M. In addition, TCL also moderately suppressed azide-induced mitochondria ROS formation.These results demonstrated that TCL was a strong antioxidant and free-radical scavenger, which might contribute to the anti-oxidative ability of Terminalia chebula Retz.",
        "keywords": [
            "Terminalia chebula Retz",
            "Anti-oxidant",
            "lipid peroxidation",
            "anti-oxidant",
            "triethylchebulate",
            "hemolysis",
            "terminalia chebula retz",
            "reactive oxygen species"
        ],
        "authors": [
            {
                "name": "Xiuping Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fangyun Sun",
                "org": "Tibet Nationalities Institute(Tibet Nationalities Institute),Xianyang,China"
            },
            {
                "name": "Lifeng Ma",
                "org": "Tibet Nationalities Institute(Tibet Nationalities Institute),Xianyang,China"
            },
            {
                "name": "Jinhua Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hailin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Indian journal of pharmacology",
        "year": 2011
    },
    "Q6ENFb9j": {
        "id": "Q6ENFb9j",
        "title": "Metabonomic Analysis of Urine from Chronic Unpredictable Mild Stress Rats Using Gas Chromatography–Mass Spectrometry",
        "abstract": "Depression is a prevalent complex psychiatric disorder and its pathophysiological mechanism is not yet well understood. In this study, we investigated the metabolic profiling of urine samples from chronic unpredictable mild stress (CUMS) rats to find potential disease biomarkers and research pathology of depression. Metabolome in urine was analyzed using gas chromatography/mass spectrometry (GC/MS) in conjunction with multivariate statistical techniques. The urine samples of male Sprague–Dawley rats were collected at different time points and then were derivatized by methoximation/silylation. Clear separation between the model and control group was achieved, and 15 metabolites were identified, which suggested that the depressed state may be related to neurotransmitter, energy metabolism and immunity. The time-dependent trajectory of metabolites pattern revealed that the maximum biochemical change happened on the 21st day, which was consistent with the results of behavior tests. The study suggested that the metabonomic approach could be used as a potentially powerful tool to investigate the biochemical change in certain physiopathological conditions, such as depression, as an early diagnostic means.",
        "keywords": [
            "Gas chromatography/mass spectrometry",
            " Depression",
            " Metabonomic",
            " Urine",
            " Time-dependent trajectory"
        ],
        "authors": [
            {
                "name": "yuzhi zhou",
                "org": "shanxi university"
            },
            {
                "name": "xingyu zheng",
                "org": "shanxi university"
            },
            {
                "name": "xiaojie liu",
                "org": "shanxi university"
            },
            {
                "name": "zhenyu li",
                "org": "shanxi university"
            },
            {
                "name": "xiaoxia gao",
                "org": "shanxi university"
            },
            {
                "name": "haifeng sun",
                "org": "shanxi university"
            },
            {
                "name": "lizeng zhang",
                "org": "shanxi university"
            },
            {
                "name": "xiaoqing guo",
                "org": "shanxi university"
            },
            {
                "name": "guanhua du",
                "org": "academy of medical sciences united kingdom"
            },
            {
                "name": "xuemei qin",
                "org": "shanxi university"
            }
        ],
        "venue": "Chromatographia",
        "year": 2012
    },
    "COBWNfBL": {
        "id": "COBWNfBL",
        "title": "1H NMR based metabolic profiling of the processing effect on Rehmanniae Radix",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pan he",
                "org": "shanxi university"
            },
            {
                "name": "zhenyu li",
                "org": "shanxi university"
            },
            {
                "name": "jie xing",
                "org": "shanxi university"
            },
            {
                "name": "xuemei qin",
                "org": "shanxi university"
            },
            {
                "name": "guanhua du",
                "org": "shanxi university"
            }
        ],
        "venue": "Analytical Methods",
        "year": 2014
    },
    "5n1YgtJE": {
        "id": "5n1YgtJE",
        "title": "Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1α-Sirt3 axis.",
        "abstract": "Salvianolic acid A (SalA) is one of the main efficacious, water-soluble constituents of Salvia miltiorrhiza Bunge. This study investigated the protective effects of SalA on peripheral nerve in diabetic rats. Administration of SalA (0.3, 1 and 3 mg/kg, ig) was started from the 5th week after strepotozotocin (STZ60 mg/kg) intraperitoneal injection and continued for 8 weeks. Paw withdrawal mechanical threshold (PWMT) and motor nerve conduction velocity (MNCV) were used to assess peripheral nerve function. The western blot methods were employed to test the expression levels of serine-threonine liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1α), silent information regulator protein3 (sirtuin 3/Sirt3) and neuronal nitric oxide synthase (nNOS) in sciatic nerve. Results showed that SalA administration could increase PWMT and MNCV in diabetic rats; reduce the deterioration of sciatic nerve pathology; increase AMPK phosphorylation level, up-regulate PGC-1α, Sirt3 and nNOS expression, but had no influence on LKB1. These results suggest that SalA has protective effects against diabetic neuropathy. The beneficial effects of SalA on peripheral nerve function in diabetic rats might be attributed to improvements in glucose metabolism through regulation of the AMPK-PGC1α-Sirt3 axis.",
        "keywords": [
            "amp-activated protein kinase",
            "diabetic neuropathy",
            "salvianolic acid a"
        ],
        "authors": [
            {
                "name": "Xiaoyan Yu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Huakang Huang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Zhonglin Huang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lili Shi",
                "org": "Tianjin Institute of Pharmaceutical Research(Tianjin Institute of Pharmaceutical Research),Tianjin,China"
            },
            {
                "name": "Hengai Zhang",
                "org": "Institute of Zoology Chinese Academy of Sciences(Chinese Academy of Sciences),Haidian,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2012
    },
    "0W2CG4TE": {
        "id": "0W2CG4TE",
        "title": "[Establishment of fingerprint of Astragali Radix polysaccharides based on endo-1,4-β-mannanase hydrolysis and identification of Astragali Radix of different germplasm resources].",
        "abstract": "The polysaccharides of different germplasm resources of Astragalus membranaceus var. mongholicus〓(cultured Astragalus Radix (RA) and natural RA) and A. membranaceus (MJ) (cultured RA and natural RA) were studied by using the optimal enzymatic conditions of endo-1,4-β-mannanase. Saccharide fingerprints were obtained for the identification and evaluation of the germplasm resources of RA by Fluorophore-assisted Carbohydrate Electrophoresis (FACE). The data were analyzed by principal component analysis to obtain the difference between RA of different germplasm resources. The results showed that trisaccharide, tetrasaccharide and pentasaccharide of endo-1,4-β-mannanase hydrolyzate could be used as the differential fragments to distinguish MG (cultured RA and natural RA); the pentasaccharide and hexasaccharide can be used as differentially expressed carbohydrate fragments that distinguish MJ (cultured RA and natural RA); the trisaccharide and tetrasaccharide can be used as the differential fragments to distinguish the cultured MG and cultured MJ. Studies have shown that polysaccharide products degraded by endo-1,4-β-mannanase can well distinguish RA species (MG and MJ), growth mode (cultured RA and natural RA). This study laid the foundation for the quality evaluation of Astragalus medicinal herbs and screening of active oligosaccharides.",
        "keywords": [
            "Astragali Radix",
            "endo-1",
            "4-β-mannanase",
            "fingerprint",
            "germplasm resources",
            "polysaccharide",
            "principal component analysis"
        ],
        "authors": [
            {
                "name": "Di Wang",
                "org": "Key Laboratory of chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Ke Li",
                "org": "Key Laboratory of chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Gui-Zhen Wang",
                "org": "Key Laboratory of chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Zhen-Yu Li",
                "org": "Key Laboratory of chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Xue-Mei Qin",
                "org": "Key Laboratory of chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xiang Zhang",
                "org": "University of Louisville, Louisville 40292, America."
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2018
    },
    "LWM0cwRf": {
        "id": "LWM0cwRf",
        "title": "Apoptosis-inducing effect of cinobufacini on human hepatoma cell line HepG2 and its mechanism of action]",
        "abstract": "To investigate the apoptosis-inducing effect of cinobufacini (Huachansu) on human hepatoma cell line HepG2 and its possible mechanism of action, HepG2 cells were treated with different concentrations of cinobufacini. Cell proliferation was measured by methylthiazolyl tetrazolium (MTT) assay. The morphological changes of apoptosis were observed by Hoechst 33258 staining. Cell cycle distribution and apoptotic rate were evaluated by flow cytometry (FCM). Quantitative real-time RT-PCR and Western blotting analysis were used to detect the mRNA and protein expressions of apoptosis related factors Bcl-2, Bax and p53. The results indicated that cinobufacini could inhibit the proliferation of HepG2 cells in a dose and time dependent manner. Remarkable morphological changes of apoptosis including cytoplasmic and nuclear condensation and partition of cytoplasm were observed by Hoechst 33258 staining. According to FCM analysis, HepG2 cells were arrested in G2/M phase and the apoptotic rate increased with the increase of the concentration of cinobufacini. Both the mRNA and protein expressions of Bax and p53 were up-regulated while Bcl-2 expression down-regulated. Thus, cinobufacini could inhibit the proliferation and induce apoptosis of human hepatoma cell line HepG2. Furthermore, up regulation of Bax and p53 as well as down regulation of Bcl-2 expressions may be one of the important apoptotic inducing mechanisms.",
        "keywords": [
            "cinobufacini",
            "proliferation",
            "apoptosis",
            "human hepatoma cell line hepg2"
        ],
        "authors": [
            {
                "name": "Fang-hua Qi",
                "org": " Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan , China"
            },
            {
                "name": "An-yuan Li",
                "org": " Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan , China"
            },
            {
                "name": "Lin Zhao",
                "org": " Department of Traditional Chinese Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan , China"
            },
            {
                "name": "Li Zhang",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Guan-hua Du",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Wei Tang",
                "org": " Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2010
    },
    "7vgrxJeJ": {
        "id": "7vgrxJeJ",
        "title": "Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors.",
        "abstract": "A disintegrin and metalloprotease with thrombospondin type I motifs-1 (ADAMTS1) plays a crucial role in inflammatory joint diseases and its inhibitors are potential candidates for anti-arthritis drugs. For the purposes of drug discovery, we reported the development and validation of fluorescence resonance energy transfer (FRET) assay for high-throughput screening (HTS) of the ADAMTS1 inhibitors. A FRET substrate was designed for a quantitative assay of ADAMTS1 activity and enzyme kinetics studies. The assay was developed into a 50-µL, 384-well assay format for high throughput screening of ADAMTS1 inhibitors with an overall Z' factor of 0.89. ADAMTS1 inhibitors were screened against a diverse library of 40,960 total compounds with the established HTS system. Four structurally related hits, naturally occurring compounds, kuwanon P, kuwanon X, albafuran C and mulberrofuran J, extracted from the Chinese herb Morus alba L., were identified for further investigation. The results suggest that this FRET assay is an excellent tool, not only for measurement of ADAMTS1 activity but also for discovery of novel ADAMTS1 inhibitors with HTS.",
        "keywords": [
            "drug discovery",
            "high-throughput screening",
            "inhibitor",
            "fluorescence resonance energy transfer",
            "adamts1",
            "high throughput screening"
        ],
        "authors": [
            {
                "name": "Jianhao Peng",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lili Gong",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Kun Si",
                "org": "Case Western Reserve University(Case Western Reserve University),Cleveland,United States"
            },
            {
                "name": "Xiaoyu Bai",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2011
    },
    "sSoqVnHU": {
        "id": "sSoqVnHU",
        "title": "Studies on the Acute Toxicity in Mice and Cytotoxicities of Impurities of Ondansetron",
        "abstract": "Objective To study the acute toxicity in mice and cytotoxicities of the impurities of Ondansetron.Methods pre-experiment to determine the initial dose,the mice were grouped randomly(half male and half female,20 mice per group) in the formal experiment.The animal reactions and death were recorded for 14 days.The cytotoxicities on fibroblasts(L929),canine kidney cells(MDCK) and human umbilical vein endothelial cells(HUVEC) were measured.Results The LD50 and 95% confidence limit of the impurity 1 of Ondansetron(intragastric administration) was 1798.8±178.2 mg·kg-1,no apparent damage was discovered in the anatomy of the viscera.The LD50 and 95% confidence limit of the impurity 2 of Ondansetron injected intravenously in mice was 49.63±7.63 mg·kg-1,shortness of breath and convulsions were shown after intravenous injection and gradually ease,no apparent damage was shown in the anatomy of the viscera.The impurity 3 of Ondansetron was adminstrated intragastriclly to mice 2 000 mg·kg-1 daily for 3 days,all mice was survived and no toxicity reactions were shown during the observed period.The purity 1,2,and 3 all significantly decreased the viability of L929 cells(P <0.05).The impurity 3 of Ondansetron significantly promoted the proliferation of HUVEC(P <0.05).Conclusion The impurity 1 and 2 of Ondansetron had certain toxicity to mice and cells.The toxicity of the impurity 3 of Ondansetron is low.The data can provide the experimental basis to establish the quality standards of Ondansetron,and improve the safety of clinic use.",
        "keywords": [
            "cytotoxicity",
            "ondansetron",
            "mice acute toxicity"
        ],
        "authors": [
            {
                "name": "WANG Yue-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "YANG Hai-guang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "LI li",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "GUO Jing",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "TONG Yuan-feng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "WU Song",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Pharmacovigilance",
        "year": 2012
    },
    "DTxaObUF": {
        "id": "DTxaObUF",
        "title": "Research progress of ciliary neurotrophic factor in metabolic syndrome",
        "abstract": "The biological characteristics of ciliary neurotrophic factor(CNTF) and its effect on metabolic syndrome(MS) are summaried in this paper.The action mechanism of CNTF in blood-lipid regulation,promoting energy metabolism,protecting nerve is analyzed,and the prospect and some problems of CNTF used in the treatment of MS are also discussed.",
        "keywords": [
            "diabetes mellitus",
            "leptin",
            "metabolic syndrome",
            "energy metabolism",
            "ciliary neurotrophic factor"
        ],
        "authors": [
            {
                "name": "LIU Qing-shan",
                "org": "National Center for Chinese Minority Traditional Medicine Research,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "CUI Jian",
                "org": "National Center for Chinese Minority Traditional Medicine Research,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "XU Si-fan",
                "org": "National Center for Chinese Minority Traditional Medicine Research,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "HUANG Xiu-lan",
                "org": "National Center for Chinese Minority Traditional Medicine Research,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LI Ke-qin",
                "org": "National Center for Chinese Minority Traditional Medicine Research,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "GU Li-li",
                "org": "National Center for Chinese Minority Traditional Medicine Research,Central University for Nationalities,Beijing ,China"
            }
        ],
        "venue": "Journal of International Pharmaceutical Research",
        "year": 2008
    },
    "2Fq4YY4T": {
        "id": "2Fq4YY4T",
        "title": "Advanced glycation end products serve as ligands for lectin-like oxidized low-density lipoprotein receptor-1(LOX-1): biochemical and binding characterizations assay.",
        "abstract": "Advanced glycation end products (AGEs) are a class of complex heterogeneous compounds which accumulate with age and is known to be involved in the pathogenesis of several diseases from diabetes to atherosclerosis. AGEs serve as ligands for multiple receptors including scavenger receptor (SR-A), CD36, and SR-BIota. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) plays an important role in both atherosclerosis and is found to be an endothelial cell receptor for AGEs. To explore the binding characterization of AGEs to LOX-1, AGEs were prepared by three different reducing sugars (d-glucose, d-fructose, and d-ribose) and the biochemical characterization including, free amino groups, free amine content, fructosamine residues, carbonyl content, fluorescence, and absorbance were determined. The binding activity was determined by FITC labeled AGEs using Chinese hamster ovary-K1 cells stably transfected with human LOX-1 gene. The obtained AGEs showed significant differences in the extent of side chain modifications, carbonyl content, fluorescence, and absorption models. All of the AGEs showed specific and saturable binding to hLOX-1-CHO-K1 cells. Furthermore, dose-dependent binding processes were observed. However, the maximal cellular binding of AGEs differs between the sugars (glucose > ribose > fructose). In addition, oxidized low-density lipoprotein (ox-LDL) could significantly inhibit the binding of AGEs to LOX-1 with different inhibitory efficiency. LOX-1 serves as receptor for AGEs which may give some insight into the role of LOX-1 in the pathogenesis of diabetes and related disorders.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiuping Chen",
                "org": ""
            },
            {
                "name": "Tiantai Zhang",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Cell biochemistry and function",
        "year": 2008
    },
    "UnvqT6na": {
        "id": "UnvqT6na",
        "title": "Comparison of the antioxidant activities of natural and cultured Cordyceps",
        "abstract": "Objective: To establish a method for the quality control of natural and cultured Cordyceps by comparing their bioactivity in vitro.Methods: The pyrogallicacid autooxidation method and the DPPH free radical scavenging method were used.Results: The cultured Cordyceps had higher antioxidant activity than the nature Cordyceps,the antioxidant activity was correlated to the contents of some components in the Cordyceps.Conclusion: The antioxidant activity could be one signal in the quality evaluation of cultured Cordyceps.",
        "keywords": [
            "antioxidant activity",
            "Cordyceps"
        ],
        "authors": [
            {
                "name": "LI Zhong-hong",
                "org": "Jiangsu Institute for Drug Control,Nanjing ,China"
            },
            {
                "name": "HU Hao-bin",
                "org": "Jiangsu Institute for Drug Control,Nanjing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "China Medical Herald",
        "year": 2008
    },
    "rrIApEvI": {
        "id": "rrIApEvI",
        "title": "Progress of Vasorelaxant Substances from Natural Products",
        "abstract": "Discovery for vasorelaxant substances from natural products has been highly focused on recently to prevent and treat many vascular diseases.In this paper,the progress in the study on the vasorelaxant substances of natural products according to various mechanisms is reviewed.",
        "keywords": [
            "Natural products",
            "Research progress",
            "Vasorelaxant",
            "Anti-hypertensive"
        ],
        "authors": [
            {
                "name": "ZHU Xiao-Ming",
                "org": "~%%#*%%#National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": "~%%#*%%#National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Natural Medicines",
        "year": 2006
    },
    "BYEtdu55": {
        "id": "BYEtdu55",
        "title": "Liver X Receptors:New Drug Target",
        "abstract": "Nuclear receptors(NRs) form a large superfamily of ligand-activated transcription factors,which can bind with DNA responsive element.The liver X receptors(LXRs) are the members of the NRs superfamily.As the cholesterol receptors in vivo,LXRs can control the absorption,metabolism,transportation and decomposition of cholesterol.Hence,LXRs can be used as a target gene for the therapy of metabolic diseases of cholesterol,such as artherosclerosis,type II diabetes mellitus,Alzheimer disease(AD),hypertension,tumor,gallstone,pneumonia syndrome,skin disease.Maybe it shall be a good pathway for the pathogenesis study of metabolic diseases and new drug discovery to find specific LXRs agonist and antagonist as well as some substance which can interfere the function of LXRs.",
        "keywords": [
            "nuclear receptors",
            "liver x receptors",
            "drug target",
            "mode of action",
            "diabetes mellitus",
            "transcription factors",
            "genes"
        ],
        "authors": [
            {
                "name": "HUANG Feng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China;Medical College of Shantou University,Shantou ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Food and Drug",
        "year": 2009
    },
    "KbtXbMtP": {
        "id": "KbtXbMtP",
        "title": "Neuroprotective effects of the effective components group of xiaoshuantongluo against oxygen-glucose deprivation in primary cultured rat cortical neurons]",
        "abstract": "This study is to investigate the effect of the effective components group of Xiaoshuantongluo (XECG) on neuronal injury induced by oxygen-glucose deprivation (OGD) in primary cortical cultures isolated from SD rat cortex at day 3 and the possible mechanism. Cells were divided into control group, OGD model group and XECG group (1, 3 and 10 mg x L(-1)). The cell viability was assessed with MTT assay and the LDH release rate was measured by enzyme label kit. The cell apoptosis was analyzed using Hoechst staining. RT-PCR was applied to detect the mRNA levels of JAK2 and STAT3. Western blotting was used to detect the expressions of Bcl-2, Bax, p-JAK2 and p-STAT3 proteins. Results showed that XECG resulted in an obvious resistance to oxygen-glucose deprivation-induced cell apoptosis and decrement of cell viability, decrease the cell LDH release rate. XECG could adjust the expression of Bcl-2 and Bax proteins and increase Bcl-2/Bax ratio, up-regulate the expression of p-JAK2 and p-STAT3. In conclusion, XECG could protect against the neuronal injury cells exposed to OGD, which may be relevant to the promotion of JAK2/STAT3 signaling pathway, and impact the expression of Bax and Bcl-2.",
        "keywords": [],
        "authors": [
            {
                "name": "Xin-Mei Xie",
                "org": ""
            },
            {
                "name": "Xiao-Bin Pang",
                "org": ""
            },
            {
                "name": "Yan Zhao",
                "org": ""
            },
            {
                "name": "Bao-Quan Wang",
                "org": ""
            },
            {
                "name": "Ruo-Yun Chen",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2014
    },
    "FfhZdPQ0": {
        "id": "FfhZdPQ0",
        "title": "Genetic risk factors for glucocorticoid-induced osteonecrosis: a meta-analysis.",
        "abstract": "Glucocorticoid-induced osteonecrosis is a common and severe adverse event. We conducted a meta-analysis to investigate whether polymorphisms in target genes were associated with the risk of corticosteroid-induced osteonecrosis. Published literature from PubMed and EMBASE were searched for eligible publications. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a fixed- or random-effects model. There were 23 articles with 35 genes described the relationship between polymorphisms and glucocorticoid-induced osteonecrosis. Meta-analyses were carried out for those SNPs with three or more eligible studies, which included four SNPs located in three genes (PAI-1, MTHFR, ABCB1). The meta-analysis revealed that the PAI-1 4G allele was associated with an increased risk of osteonecrosis compared with the 5G allele (combined studies: OR=1.932, 95% CI=1.145-3.261). The OR for the 4G/4G vs. 5G/5G genotype of PAI-1 was 3.217 (95% CI 1.667-6.209 with combined studies), The relative risk of osteonecrosis was increased in the 4G allele vs. 5G/5G and 4G/4G genotype vs. 5G allele, with odds ratios of 2.304 (95% CI=1.235-4.299) and 2.307 (95% CI=1.527-3.485) in combined studies, respectively. The ABCB1 C3435T genotype distributions available confirmed that the C allele increased osteonecrosis risk compared with the T allele (OR 1.668, 95% CI=1.214-2.293) and TT genotype (OR 2.946, 95% CI=1.422-6.101). There was no evidence for significant association between MTHFR C677T and ABCB1 G2677T/A polymorphisms and risk of osteonecrosis. Results of this meta-analysis indicate that the PAI-1 4G/5G and ABCB1 C3435T polymorphisms may be risk factors for osteonecrosis.",
        "keywords": [
            "plasminogen activator inhibitor-1",
            "osteonecrosis",
            "glucocorticoid",
            "polymorphism",
            "abcb1",
            "meta-analysis",
            "meta analysis"
        ],
        "authors": [
            {
                "name": "Li-Li Gong",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "He-Yao Wang",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Jian-Hao Peng",
                "org": "Cleveland Clinic Foundation(Cleveland Clinic Foundation,Cleveland Clinic),Cleveland,United States"
            },
            {
                "name": "Kun Si",
                "org": "Case Western Reserve University(Case Western Reserve University),Cleveland,United States"
            },
            {
                "name": "Jin Zhu",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Fei-Fei Han",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Yue-Hua Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Li-Xia Pei",
                "org": "Shanghai University of Traditional Chinese Medicine(Shanghai University of Traditional Chinese Medicine,Shanghai University of TCM),Shanghai,China"
            },
            {
                "name": "Li-Hong Liu",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            }
        ],
        "venue": "Steroids",
        "year": 2013
    },
    "lavOKtDH": {
        "id": "lavOKtDH",
        "title": "Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway.",
        "abstract": "Neuroinflammation has been demonstrated to be linked with Parkinson's disease (PD), Alzheimer's disease, and cerebral ischemia. Our previous investigation had identified that kaempferol (KAE) exerted protective effects on cortex neuron injured by LPS. In this study, the effects and possible mechanism of KAE on striatal dopaminergic neurons induced by LPS in mice were further investigated. The results showed that KAE improved striatal neuron injury, and increased the levels of tyrosine hydroxylase (TH) and postsynaptic density protein 95 (PSD95) in the striatum of mice. In addition, KAE inhibited the production of pro-inflammatory cytokines, including interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), reduced the level of monocyte chemotactic protein-1 (MCP-1), intercellular cell adhesion molecule-1 (ICAM-1), and cyclooxygenase-2 (COX-2) in the striatum tissues. Furthermore, KAE protected blood-brain barrier (BBB) integrity and suppressed the activation of the HMGB1/TLR4 inflammatory pathway induced by LPS in striatum tissues of mice. In conclusion, these results suggest that KAE may have neuroprotective effects against striatum injury that is induced by LPS and the possible mechanisms are involved in anti-neuroinflammation, maintaining BBB integrity, and down-regulating the HMGB1/TLR4 pathway.",
        "keywords": [
            "high mobility group box 1 (HMGB1)",
            "kaempferol",
            "lipopolysaccharide (LPS)",
            "neuroinflammation",
            "striatum"
        ],
        "authors": [
            {
                "name": "Ying-Lin Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. yinglin@imm.ac.cn."
            },
            {
                "name": "Xiao Cheng",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. chengxiao@imm.ac.cn."
            },
            {
                "name": "Wei-Han Li",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. liwenhan@imm.ac.cn."
            },
            {
                "name": "Man Liu",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. liuman2018@yeah.net."
            },
            {
                "name": "Yue-Hua Wang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. wangyuehua@pku.org.cn."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "International journal of molecular sciences",
        "year": 2019
    },
    "ECI39hag": {
        "id": "ECI39hag",
        "title": "Qualitative and quantitative analysis for determination of related substances in fluorouracil raw materials and its injection",
        "abstract": "Objective: To establish a qualitative and quantitative analysis method for the determination of the 5 related substances in fluorouracil raw materials and its injection.Methods: The high-performance liquid chromatography(HPLC) was used for the analysis,a Kromacil C18 column(250 mm × 5 mm,5 μm) was used as the analytical column,methanol-water(phosphoric acid adjusted to pH 3.5)(5∶ 95) were used as the mobile phase at a flow rate of 1.0 mL.min-1,the detection wavelength was 265 nm,and the column temperature was 35 ℃.The standard curve method,and the main component self control method with and without correction factor were used for the quantitative analysis of the related substances respectively.Results: The regression equation,linear range,relative retention time,and correction factor of five related substances were measured respectively.The average recovery of each reference substance was more than 95%,and the average RSD values for precision and reproducibility were both less than 1.5%.By comparison,the main component self control method with correction factor was more accurate and simple to calculate the content of related substances.Conclusion: The method can be used for the qualitative and quantitative analysis of the related substances in fluorouracil injection and raw materials,and the main component self control method with correction factor can reflect the content of impurities D(correction factor 1.5) more accurately.",
        "keywords": [
            "HPLC",
            "fluorouracil injection",
            "related substances",
            "correction factor",
            "fluorouracil raw material"
        ],
        "authors": [
            {
                "name": "WANG Chang-he",
                "org": "Shaanxi Institute for Food and Drug Control,Xi'an ,China"
            },
            {
                "name": "ZHANG Zhen",
                "org": "Shaanxi University of Chinese Medicine,Xianyang ,China"
            },
            {
                "name": "LIU Hai-jing",
                "org": "Shaanxi Institute for Food and Drug Control,Xi'an ,China"
            },
            {
                "name": "DING Li-xia",
                "org": "Chinese Pharmaceutical Association,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Beijing City Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Pharmaceutical Analysis",
        "year": 2013
    },
    "U5V7qmHA": {
        "id": "U5V7qmHA",
        "title": "Necroptosis: a new mechanism of cell death]",
        "abstract": "Traditionally, cell death has been categorized into apoptosis or necrosis. However, a growing number of research indicates necroptosis, distinct from apoptosis and necrosis, contributes to a range of human diseases as a new mechanism of cell death. In order to achieve a better understanding of different cell death models and an improvement for development of new drugs associated with this pathway, the mechanism of necroptosis, the differences among apoptosis, necrosis and necroptosis, as well as the role of necroptosis in human diseases and its relation to discovery of drug targets, are discussed in this article.",
        "keywords": [
            "necroptosis",
            "cell death",
            "apoptosis",
            "necrosis"
        ],
        "authors": [
            {
                "name": "Bai-Nian Chen",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , China"
            }
        ],
        "venue": "Sheng li ke xue jin zhan [Progress in physiology]",
        "year": 2010
    },
    "Wjka4Faq": {
        "id": "Wjka4Faq",
        "title": "Screening of Xiaoshuantongluo effective components group",
        "abstract": "Aim: To further investigate the substance basis through tracking the effective components which account for the therapeutical effects of Xiaoshuantongluo(XSTL),based on the effective components group theory and previous high throughput screening results.Methods: Tracking the therapeutic activities of different fractions prepared from XSTL with in vitro vasodilation function in rat aortic rings,chemical hypoxia induced injury in endothelial cells,oxygen-glucose deprive injury in nerve cells,DPPH radical scavenging activity,and FeSO 4/Cysteine induced brain mitochondrial oxidative damage model.Results: Integrated multi-model screening suggested that the therapeutical effects of the fractions XSTL002,XSTL005 and XSTL007 are potent and consistent which prepared by different extract process.Conclusion: In different fractions prepared from XSTL,the fraction XSTL002,XSTL005 and XSTL007 are the major effective fractions against multi-factors accounting for stroke pathogenesis,and they are the effective component group of XSTL.",
        "keywords": [
            "effective component group",
            "Xiaoshuantongluo Recipe(消栓通络方)"
        ],
        "authors": [
            {
                "name": "Tan Chubing",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ; Tianjin Key Lab of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin "
            },
            {
                "name": "Gao Mei",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing "
            },
            {
                "name": "Wang Hongqing",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing "
            },
            {
                "name": "Xu Weiren",
                "org": " Tianjin Key Lab of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin "
            },
            {
                "name": "Chen Ruoyun",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing "
            },
            {
                "name": "Du Guanhua",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing "
            }
        ],
        "venue": "Pharmacology and Clinics of Chinese Materia Medica",
        "year": 2011
    },
    "geYphJ1U": {
        "id": "geYphJ1U",
        "title": "Studies on the potential link between antidepressant effect of Xiaoyao San and its pharmacological activity of hepatoprotection based on multi-platform metabolomics.",
        "abstract": "XYS could significantly improve the depressive and liver injury symptoms induced by CUMS. The metabolomics results indicate that the regulation of glutamine and glutamate metabolism to maintain the balance of ammonia and promote energy metabolism is a potential junction between the antidepressant and hepatoprotective effects of XYS.",
        "keywords": [
            "Antidepressant",
            "Glutamine and glutamate metabolic pathway",
            "Hepatoprotection",
            "NMR and LC/MS-Based metabonomics",
            "Xiaoyao san"
        ],
        "authors": [
            {
                "name": "Congcong Chen",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China; College of Chemistry and Chemical Engineering, Shanxi University, No. 92, Wucheng Road, Taiyuan, 030006, PR China."
            },
            {
                "name": "Qicai Yin",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China; College of Chemistry and Chemical Engineering, Shanxi University, No. 92, Wucheng Road, Taiyuan, 030006, PR China."
            },
            {
                "name": "Junshen Tian",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China."
            },
            {
                "name": "Xiaoxia Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China."
            },
            {
                "name": "Guanhua Du",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Yuzhi Zhou",
                "org": "Modern Research Center for Traditional Chinese Medicine of Shanxi University, No.92, Wucheng Road, Taiyuan, 030006, PR China. Electronic address: zhouyuzhi@sxu.edu.cn."
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2019
    },
    "dsZW13Z2": {
        "id": "dsZW13Z2",
        "title": "Optimization and application of the high-throughput screening assay for acetylcholinesterase inhibitors",
        "abstract": "Objective: To optimize the high-throughput screening assay for acetylcholinesterase inhibitors (AChEIs), and discover novel active compounds for Alzheimer's disease treatment. Methods: A series of wavelength, substrate concentration, enzyme concentration, pH, incubation temperature and time of the screening system were evaluated and Z' factor of the model was detected to observe the stability of this model. Results: A high-throughput screening model for AChEIs was optimized with wavelength 412 nm, substrate concentration 5 mmol · L-1, 20 multiple dilution of AChE, incubation temperature 37°C, incubation time 30 min, pH range 7.4~8.0 and Z' factor 0.654. A number of AChEIs were discovered during high-throughput screening. Conclusion: The optimized high-throughput screening system is stable, reliable and sensitive that can be successfully used to high-throughput screening of AChEIs.",
        "keywords": [
            "Acetylcholinesterase inhibitor",
            "Alzheimer's disease",
            "High-throughput screening",
            "Piperazine derivatives",
            "Structure-activity relationship"
        ],
        "authors": [
            {
                "name": "FENG Zhang-ying",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dan Zhou",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "YANG Ran-yao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LIU Ai-lin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2013
    },
    "o88TX2M4": {
        "id": "o88TX2M4",
        "title": "Role of α3-containing nicotinic acetylcholine receptors subtype in vascular inflammation.",
        "abstract": "Vascular inflammation is a major factor contributing to the development of vascular diseases. The aim of this study was to investigate the role of α3-containing nicotinic acetylcholine receptors subtype (α3-nAChRs) in vascular inflammation.Vascular inflammation was studied in the apolipoprotein E knock-out (ApoE(-/-) ) mice fed with a high-fat diet. Inflammatory markers were detected in mouse aortic endothelial cells (MAECs) and macrophages after α3-nAChRs were antagonized pharmacologically or after the gene of α3-nAChRs was silenced.Upon the treatment with α-conotoxin MII (MII, an α3-nAChRs antagonist), the amount of infiltrated inflammatory cells into aortic walls was increased and the endothelium-dependent vasodilatations were further impaired in the aorta of ApoE(-/-) mice. The plasma levels of inflammatory cytokines were also increased by MII. Besides, the amount of infiltration of classical activated macrophages into the arterial wall of ApoE(-/-) mice was markedly elevated by MII but that of alternative activated macrophages was reduced. In MAECs, the lipopolysaccharide-stimulated secretions of adhesion molecules and inflammatory cytokines were enhanced by MII or after the gene of α3-nAChRs was silenced. This effect was reversed by inhibitors of PI3 k-Akt-IkKα/β-IkBα-NFkB pathways. In macrophages, the classical activation was enhanced but the alternative activation was reduced when the gene of α3-nAChRs was silenced. These effects were prevented by the inhibitors of IkKα/β-IkBα-NFkB pathways and JAK2-STAT6-PPARγ pathways, respectively. This article is protected by copyright. All rights reserved.α3-nAChRs play a pivotal role in regulating the inflammatory responses in endothelial cells and macrophages. The mechanisms involve the modulations of multiple cell signaling pathways.",
        "keywords": "",
        "authors": [
            {
                "name": "Cui Yang",
                "org": "Ethnic Drug Screening &amp; Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University, Kunming, China."
            },
            {
                "name": "Zhengtao Li",
                "org": "Ethnic Drug Screening &amp; Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University, Kunming, China."
            },
            {
                "name": "Saimei Yan",
                "org": "Ethnic Drug Screening &amp; Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University, Kunming, China."
            },
            {
                "name": "Yonghui He",
                "org": "Ethnic Drug Screening &amp; Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University, Kunming, China."
            },
            {
                "name": "Rong Dai",
                "org": "Department of Pharmacology, Yunnan University of TCM, Kunming, China."
            },
            {
                "name": "George Pek-Heng Leung",
                "org": "Department of Pharmacology &amp; Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China."
            },
            {
                "name": "Shitian Pan",
                "org": "Ethnic Drug Screening &amp; Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University, Kunming, China."
            },
            {
                "name": "Jinyan Yang",
                "org": "Ethnic Drug Screening &amp; Pharmacology Center, Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &amp; Ministry of Education, Yunnan Minzu University, Kunming, China."
            },
            {
                "name": "Rong Yan",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."
            }
        ],
        "venue": "British journal of pharmacology",
        "year": 2016
    },
    "0qyj0WmI": {
        "id": "0qyj0WmI",
        "title": "A GC-MS urinary quantitative metabolomics analysis in depressed patients treated with TCM formula of Xiaoyaosan.",
        "abstract": "Xiaoyaosan, one of the best-known traditional Chinese medicine prescriptions, has been widely used in China for the treatment of mental disorders such as depression. Although both clinical application and animal experiments indicate that Xiaoyaosan has an obvious antidepressant effect, the mechanism still remains unclarified, and there are few studies quantitatively measured the biomarkers of Xiaoyaosan treatment by metabolomics to determination. In this study, 25 depressed patients and 33 healthy volunteers were recruited. A GC-MS based metabolomics approach and the multivariate statistical methods were used for analyzing the urine metabolites of depressed patients before and after treatment compared with healthy controls. Then the biomakers through metabolomics determination were carried out the quantitative analysis. In total, 5 metabolites were identified as the potential diseased and therapeutic biomarkers of depression and Xiaoyaosan. Alanine, citrate and hippurate levels were significantly increased in the urine samples from depressed patients compared with healthy controls, while phenylalanie and tyrosine levels were significantly decreased. However, after Xiaoyaosan treatment for 6 weeks, phenylalanie and tyrosine levels were significantly increased (p<0.05) and alanine, citrate and hippurate levels significantly decreased (p<0.05). Xiaoyaosan has a good priority on the treatment of depression and the ability to adjust the neurotransmitters to obtain the best treated response and also could regulate the metabolism of amino acids and promote to produce energy meet the needs of the body.",
        "keywords": [
            "Depression",
            "Gas chromatography–mass spectrometry (GC–MS)",
            "Metabolomics",
            "Quantitative analysis",
            "Xiaoyaosan"
        ],
        "authors": [
            {
                "name": "Jun-Sheng Tian",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Guo-Jiang Peng",
                "org": "Affiliated Hospital of Xiangnan University, Chenzhou 423000, PR China."
            },
            {
                "name": "Yan-Fei Wu",
                "org": "Department of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, Taiyuan 030001, PR China."
            },
            {
                "name": "Jian-Jun Zhou",
                "org": "Affiliated Hospital of Xiangnan University, Chenzhou 423000, PR China."
            },
            {
                "name": "Huan Xiang",
                "org": "Physical Education Department of Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Xiao-Xia Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Yu-Zhi Zhou",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Xue-Mei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China; Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, PR China."
            }
        ],
        "venue": "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences",
        "year": 2015
    },
    "2p8Ug466": {
        "id": "2p8Ug466",
        "title": "Effects of stem cell therapy on left ventricular remodeling after acute myocardial infarction: a meta-analysis.",
        "abstract": "The objective was to perform a meta-analysis of clinical trials that investigated the effects of stem cell therapy on left ventricular remodeling in patients after acute myocardial infarction (AMI).Intracoronary injection of stem cells in the acute phase of myocardial infarction has been proposed to replace the cardiomyocytes lost and to prevent deleterious pathological remodeling after myocardial infarction. Previously published trials have investigated the effects of cell therapy on left ventricular (LV) remodeling in AMI patients. However, the sample size of these studies is small and the conclusions are inconsistent.Trials were identified in the Cochrane Library, EMBASE, and PubMed databases, reviews, and reference lists of relevant articles. The weighted mean difference (WMD) was calculated for net changes in LV end-diastolic and end-systolic volumes (LVEDV and LVESV) by using fixed-effect models.A total of 11 trials (13 comparisons) with 832 participants evaluated the association between stem cell therapy and changes in LVEDV. Compared with the control group, stem cell therapy did not influence the LVEDV changes from baseline to follow-up (WMD: - 1.76 mL, 95% confidence interval [CI]: - 4.61 to 1.08 mL, P = 0.233). A total of 9 trials (11 comparisons) with 797 participants evaluated the association between stem cell therapy and changes in LVESV. Compared with the control group, patients in the cell therapy group had a significantly greater reduction in LVESV from baseline to follow-up (WMD: - 5.08 mL, 95% CI: - 7.80 to - 2.37 mL, P < 0.001).This meta-analysis suggests that cell therapy improves left ventricular contractility, but has no effect on LV remodeling.",
        "keywords": [],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xi Lan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Clinical cardiology",
        "year": 2010
    },
    "u0b6QlPS": {
        "id": "u0b6QlPS",
        "title": "Inhibitory effects and mechanism of extracts from Guizhi Fuling on the proliferation in human cervical carcinoma cells",
        "abstract": "OBJECTIVE: To investigate the inhibitory effects of different solvent extracts from Guizhi Fuling on the proliferation in human cervical carcinoma cells and its possible mechanisms. METHODS: MTT assay was used to detect the proliferation in the HeLa and C33A human cervical carcinoma cells, and the enzyme-linked immunosorbent assay was used detect for the protein tyrosine kinases (PTKs) activity in vitro, and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) scavenging ratio displayed antioxidant activity of different extracts from Guizhi Fuling. RESULTS: Most of different solvent extracts from Guizhi Fuling, including extracts of ethyl acetate, ethyl acetate-water, ethyl acetate-acetone, butyl alcohol-30% ethanol and butyl alcohol-50% ethanol, displayed good inhibitory activity on the proliferation in human cervical carcinoma cells. The inhibit potency to the largest for HeLa cells was butyl alcohol-30% ethanol eluate, its IC 50 was (7.09±1.25) μg·mL -1, and inhibit potency to the largest for C33A cells was ethyl acetate-acetone eluate, its IC 50 was (5.14±0.70) μg·mL -1. CONCLUSION: These results suggested that different solvent extracts from Guizhi Fuling, have different anticancer activity in vitro. Its mechanism may be associated with inhibition of PTKs and antioxidation activity. Copyright 2012 by the Chinese Pharmaceutical Association.",
        "keywords": [
            "Anticarcinoma",
            "Antioxidation",
            "Cervical carcinoma",
            "Extracts",
            "Guizhi Fuling",
            "Protein tyrosine kinases"
        ],
        "authors": [
            {
                "name": "FANG Lian-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "CHEN Ruo-yun",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Jing Guo",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "YANG Hai-guang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "WANG Hong-qing",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LI Jia-chun",
                "org": "Jiangsu Kanion Pharmaceutical Co., Ltd.(Jiangsu Kanion Pharmaceutical Co. Ltd.,Jiangsu Kanion Pharmaceutical Co., Ltd.),Nanjing,China"
            },
            {
                "name": "FAN Qi-ru",
                "org": "Jiangsu Kanion Pharmaceutical Co., Ltd.(Jiangsu Kanion Pharmaceutical Co. Ltd.,Jiangsu Kanion Pharmaceutical Co., Ltd.),Nanjing,China"
            },
            {
                "name": "WANG Zhen-zhong",
                "org": "Jiangsu Kanion Pharmaceutical Co., Ltd.(Jiangsu Kanion Pharmaceutical Co. Ltd.,Jiangsu Kanion Pharmaceutical Co., Ltd.),Nanjing,China"
            },
            {
                "name": "Wei Xiao",
                "org": "Jiangsu Kanion Pharmaceutical Co., Ltd.(Jiangsu Kanion Pharmaceutical Co. Ltd.,Jiangsu Kanion Pharmaceutical Co., Ltd.),Nanjing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2012
    },
    "WqzIWveA": {
        "id": "WqzIWveA",
        "title": "The flavonoid apigenin protects brain neurovascular coupling against amyloid-β₂₅₋₃₅-induced toxicity in mice.",
        "abstract": "Apigenin, one of the most common flavonoids, has demonstrated anti-inflammatory, anticarcinogenic, and free radical-scavenging activities. Recent studies revealed its protective effects against amyloid-β (Aβ)-induced neurotoxicity, but the mechanism was unclear. In the present study, we aimed to explore the anti-amnesic and protective effects of apigenin against Aβ₂₅₋₃₅-induced toxicity and the underlying mechanisms in the cerebral cortex in mice. The learning and memory impairments, changes in morphology of major components of neurovascular unit, ultrastructural changes and oxidative stress of cerebral cortex, cerebrovascular dysfunction, and neuronal changes were detected after oral administration of apigenin continuously for 8 days. Our results demonstrate that oral administration of apigenin for Aβ₂₅₋₃₅-induced amnesic mice conferred robust neurovascular coupling protection, involving improvement of the learning and memory capabilities, maintenance of neurovascular unit integrity, modulation of microvascular function, reduction of neurovascular oxidative damage, increase of regional cerebral blood flow, improvement of cholinergic system involving the inhibition of AChE activity and elevation of ACh level, and modification of BNDF, TrkB, and phospho-CREB levels.",
        "keywords": [],
        "authors": [
            {
                "name": "Rui Liu",
                "org": "National Centre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Tiantai Zhang",
                "org": ""
            },
            {
                "name": "Haiguang Yang",
                "org": ""
            },
            {
                "name": "Xi Lan",
                "org": ""
            },
            {
                "name": "Jian Ying",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Journal of Alzheimer's disease : JAD",
        "year": 2011
    },
    "tsC9o04N": {
        "id": "tsC9o04N",
        "title": "Synthesis and activity study of N-(substituted)benzoyl-N′-substituted pyrimidinyl thiourea derivatives",
        "abstract": "Aim To synthesize a new series of N-(substituted)benzoyl-N′-substituted pyrimidinyl thiourea derivatives and to evaluate their inhibitory activities against vascular smooth muscle cells proliferation.Methods The subject compounds could be obtained by direct amination of(substituted)benzoyl isothiocyanate with 2-amino-5-bromo-4-substituted pyrimidine derivatives.The inhibitory effect of the target compounds on VSMC proliferation was investigated by MTT.Results and conclusion Ten target new compounds were first synthesized and verified by 1H-NMR and MS.Compound 6b,6c,6g and 6j exhibited moderate inhibitory activities against vascular smooth muscle cells proliferation.",
        "keywords": [
            "vascular smooth muscle cells",
            "acylthiourea pyrimidine derivative",
            "proliferation",
            "chemical synthesis"
        ],
        "authors": [
            {
                "name": "TIAN Jing",
                "org": "School of Pharmaceutical Science,Shanxi Medical University,Taiyuan ,China"
            },
            {
                "name": "BAN Shu-rong",
                "org": "School of Pharmaceutical Science,Shanxi Medical University,Taiyuan ,China"
            },
            {
                "name": "FANG Lian-hua",
                "org": "Institute of MateriaMedica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of MateriaMedica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LI Qing-shan",
                "org": "School of Pharmaceutical Science,Shanxi Medical University,Taiyuan ,China"
            }
        ],
        "venue": "Chinese Journal of Medicinal Chemistry",
        "year": 2010
    },
    "q1wbVtTu": {
        "id": "q1wbVtTu",
        "title": "Chemical and pharmacological research on the polyphenol acids isolated from Danshen: A review of salvianolic acids.",
        "abstract": "Danshen, the dried root of Salvia miltiorrhiza Bge, is a common medicinal herb in Traditional Chinese Medicine, which has been used for the treatment of a number of diseases for thousands of years. More than 2000 years ago, the Chinese early pharmacy monograph \"Shennong Materia Medica\" recorded that Danshen could be used for the treatment of gastrointestinal diseases, cardiovascular diseases, certain gynecological diseases, etc. Since then, Danshen has been widely used clinically in many different prescriptions for many different diseases, especially for the treatment of cardiovascular diseases. Nowadays, many pharmacological studies about the water-soluble components from Danshen have been reported, especially salvianolic acids. It turned out that salvianolic acids showed strong anti-lipid peroxidation and anti-thrombic activities, and among them, SalAA and SalAB were the most potent. This review focused on the achievements in research of salvianolic acids regarding their bioactivities and pharmacological effects. These studies not only shed light on the water-soluble active components of Danshen and their mechanisms at the molecular level, but also provided theoretical information for the development of new medicines from Danshen for the treatment of cardiovascular and cerebrovascular diseases, inflammatory diseases, metabolic diseases, etc.",
        "keywords": [
            "Cardiovascular diseases",
            "Cerebrovascular diseases",
            "Danshen",
            "Metabolic diseases",
            "SalAA",
            "SalAB",
            "SalAC",
            "Salvianolic acids"
        ],
        "authors": [
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. Electronic address: dugh@imm.ac.cn."
            },
            {
                "name": "Junke Song",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Lida Du",
                "org": "Department of Surgery, University of Toronto, Toronto, ON, Canada."
            },
            {
                "name": "Li Zhang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Guifen Qiang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Shoubao Wang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Xiuying Yang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Lianhua Fang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China."
            }
        ],
        "venue": "Advances in pharmacology (San Diego, Calif.)",
        "year": 2020
    },
    "TFDOeQbk": {
        "id": "TFDOeQbk",
        "title": "Related Substances study in Ibuprofen Raw Materials and Its Preparations",
        "abstract": "OBJECTIVE To establish the determination method of the related substances in ibuprofen raw materials,tablets and capsules.METHODS High performance liquid chromatography(HPLC) was used for the determination of 2-(4-isobutyl phenyl) propanoic acid,4-isobutyl benzoic acid,sodium methyl hydroxybenzoate(provided by national institutes for food and drug control),4′-isobutyl acetophenone(known impurities of JP),the relative substance A,J,N(known impurities of EP),and the unknown impurities.A Kromasil C18 column(4.6 mm×250 mm,5 μm) was used as the analytical column,acetonitrile-water(pH adjusted to 3.0 by phosphoric acid)(45∶55) were used as the mobile phase,the flowing rate was 1.0 mL·min-1,the detection wavelength was set at 254 nm,and the column temperature was 35 ℃.RESULTS The relative substances detected in ibuprofen raw materials and its preparations were mainly 4-isobutyl benzoic acid and 4′-isobutyl acetophenone.The contents of unknown impurities were also high in the preparations of some manufacturers.CONCLUSION The method can be used for the analysis of the related substances in ibuprofen raw materials and its preparations.",
        "keywords": [
            "HPLC",
            "ibuprofen raw material",
            "related substance",
            "4-isobutyl benzoic acid",
            "ibuprofen preparation",
            "2-(4-isobutyl phenyl) propanoic acid"
        ],
        "authors": [
            {
                "name": "ZHANG Bing-hua",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "WANG Fa",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "MENG Xin-fang",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "XU Chang-gen",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "LIU Hai-jing",
                "org": "Shanxi Institute for Food and Drug Control,Xi′an ,China"
            },
            {
                "name": "DING Li-xia",
                "org": "Chinese Pharmaceutical Association,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2013
    },
    "nyKg1RqH": {
        "id": "nyKg1RqH",
        "title": "Baicalein attenuates caspase-independent cells death via inhibiting PARP-1 activation and AIF nuclear translocation in cerebral ischemia/reperfusion rats.",
        "abstract": "It is reported that baicalein can activate PI3K/AKT pathway, inhibit caspase activation and reduce cerebral infarct volume in middle cerebral artery occlusion (MCAO) rats. However, a caspase-independent mechanism initiated by poly (ADP-ribose) polymerase-1 (PARP-1) activation has been reported to make more contribution to cells death after ischemic stroke. In the present study, we established a cerebral ischemia/reperfusion (I/R) rat model through middle cerebral artery occlusion following reperfusion to investigate the mechanisms of ischemic tissue recovery following baicalein treatment. The data showed that baicalein treatment at dose of 100 mg/kg for 7 days significantly inhibited the release of cytokines, activation of PARP-1, nuclear translocation of apoptosis-inducing factor (AIF) and macrophage migration inhibitory factor (MIF) in cerebral I/R rats, therefore decreased cerebral infarct volume and neurological scores. Then, we further investigated the signal transduction mechanisms of ischemic tissue protection by baicalein in vitro. Following oxygen and glucose deprivation (OGD) in SH-SY5Y cells, the mitochondrial AIF was translocated into nucleus after 12 h. The co-immunoprecipitation analysis showed that the interaction between AIF and MIF was activated by OGD and subsequently resulted in MIF nuclear translocation. Also, the baicalein inhibited apoptosis, reduced oxidative stress, protected mitochondrial function and restored mitochondrial membrane potential in OGD cells. The results obtained from both in vivo and in vitro study demonstrated the PARP-1/AIF pathway involved in mechanisms of baicalein to protect the cerebral tissues from ischemic injury.",
        "keywords": [
            "Programed cells death",
            " PARP-1 activation",
            " AIF nuclear translocation",
            " Parthanatos"
        ],
        "authors": [
            {
                "name": "Wei-Han Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Ying-Lin Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Xiao Cheng",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Man Liu",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Shan-Shan Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Yue-Hua Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            }
        ],
        "venue": "Apoptosis",
        "year": 2020
    },
    "d40YoWAl": {
        "id": "d40YoWAl",
        "title": "Baicalein protects PC12 cells from Aβ 25-35 -induced cytotoxicity via inhibition of apoptosis and metabolic disorders.",
        "abstract": "Our study revealed that baicalein has a protective effect on Aβ-induced neurotoxicity in PC12 cells, which may be related to inhibition of apoptosis and metabolic disorders.",
        "keywords": [
            "Apoptosis",
            "Aβ(25–35)",
            "Baicalein",
            "LC-MS metabolomics"
        ],
        "authors": [
            {
                "name": "Li Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China. Electronic address: gaoli87@sxu.edu.cn."
            },
            {
                "name": "Feng Zhou",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China; College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Ke-Xin Wang",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China; College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Yu-Zhi Zhou",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China."
            },
            {
                "name": "Xue-Mei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, PR China. Electronic address: qinxm@sxu.edu.cn."
            }
        ],
        "venue": "Life sciences",
        "year": 2020
    },
    "IBeFI2YZ": {
        "id": "IBeFI2YZ",
        "title": "New progress in the pharmacology of apigenin",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Du Guan-hua",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100050,China)"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2008
    },
    "9aCbOkRk": {
        "id": "9aCbOkRk",
        "title": "WS0701: a novel sedative–hypnotic agent acting on the adenosine system",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiku zhang",
                "org": ""
            },
            {
                "name": "zhonglin huang",
                "org": ""
            },
            {
                "name": "rui liu",
                "org": ""
            },
            {
                "name": "linghua hao",
                "org": ""
            },
            {
                "name": "song wu",
                "org": ""
            },
            {
                "name": "yonghe zhang",
                "org": ""
            },
            {
                "name": "xueqiong zhang",
                "org": ""
            },
            {
                "name": "xiaoyu bai",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "zongmiao sun",
                "org": ""
            }
        ],
        "venue": "Behavioural Pharmacology",
        "year": 2014
    },
    "9dloAzWj": {
        "id": "9dloAzWj",
        "title": "Identification of ligands for human LOX-1 through fluorescence polarization-based high throughput screening]",
        "abstract": "To develop a fluorescence polarization-based high throughput screening and identify ligands for human Lectin-like oxidized low-density lipoprotein receptor-1 (hLOX-1).Sequential ultracentrifugation at 4 degrees C from normolipidemic fasting volunteers to obtain low density lipoprotein (LDL), which was modified by CuSO4 (5 micromol x L(-1)) at 37 degrees C for 24 h. The assay was based on the interaction between receptor and ligand, and hLOX-1 was labeled by FITC and bound to its specific ligand, oxLDL. Different reaction time and DMSO concentration were optimized to determine the stability and tolerance of fluorescence polarization (FP) assay. 3 200 compounds were screened in black 384-well microplate by FP-based competitive displacement assay, at excitation filter of 485 nm and emission filter of 530 nm. Z' was used to assess the assay quality.The FP-based HTS was formatted in a 384-well microplate with a Z' factor of 0. 75, and three active compounds for hLOX-1 were identified with IC50 below 40 micromol x L(-1) from total 3 200 compounds.The results indicated that the fluorescence polarization assay is stable, sensitive, reproducible and well suited for high throughput screening efforts.",
        "keywords": [
            "high throughput screening",
            "fluorescence polarization",
            "atherosclerosis",
            "lox-1"
        ],
        "authors": [
            {
                "name": "Tian-Tai Zhang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Zhen-Tai Huang",
                "org": ""
            },
            {
                "name": "Ying Dai",
                "org": ""
            },
            {
                "name": "Ai-Lin Liu",
                "org": ""
            },
            {
                "name": "Ping Zhu",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2005
    },
    "CR3MN9Le": {
        "id": "CR3MN9Le",
        "title": "Tyrosine sulfation in the N-terminal domain of human C5aR is necessary for high-affinity binding of chemotaxis inhibitory protein of staphylococcus aureus",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhenjia liu",
                "org": "peking union medical college"
            },
            {
                "name": "aixia wang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "jinming gao",
                "org": "peking union medical college"
            }
        ],
        "venue": "European Respiratory Journal",
        "year": 2011
    },
    "jOlr8fAz": {
        "id": "jOlr8fAz",
        "title": "Current studies on modulation of cancer multidrug resistance by flavonoids",
        "abstract": "Multi-drug resistance(MDR) is one of the key causes of failures in cancer chemotherapy.Flavonoids are broadly distributed in plants and have multiple pharmacological activities.The flavonoids may be possible modulators of MDR because they have inhibitory activity on drug transporters,such as P-gp,MRP and BCRP.This article summarized the inhibitory effects of flavonoids on ABC transporters in aspects of research process,action mechanism and structure-activity relationship,in order to provide important information for development and application of the modulators.",
        "keywords": [
            "ABC transporter",
            "Breast cancer resistance protein (BCRP)",
            "Flavonoids",
            "Multidrug resistance (MDR)",
            "Multidrug resistance associated protein (MRP)",
            "P-glycoprotein(P-gp)"
        ],
        "authors": [
            {
                "name": "YANG Fan",
                "org": "Insititute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Ailin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Insititute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2010
    },
    "majEEHKn": {
        "id": "majEEHKn",
        "title": "Flavonoids from the bran of Avena sativa : Flavonoids from the bran of Avena sativa",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "x u jiekun",
                "org": ""
            },
            {
                "name": "weiku zhang",
                "org": ""
            },
            {
                "name": "li zhang",
                "org": ""
            },
            {
                "name": "du guanhua",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Natural Medicines",
        "year": 2012
    },
    "oxqCGEW8": {
        "id": "oxqCGEW8",
        "title": "The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats.",
        "abstract": "The therapeutic effect of pinocembrin, together with the therapeutic time window, in the transient global cerebral ischemia/reperfusion (I/R) rats was investigated.Adult male Sprague-Dawley rats were subjected to global cerebral ischemia for 20 min by four-vessel occlusion. Pinocembrin (1 and 5mg/kg) was administrated intravenously 30 min before ischemia and 30 min, 2h, 6h after reperfusion, respectively. Neurological scores, brain edema and histological examination by Nissl staining were employed to assess the neuronal injury after ischemia and the neuroprotection by pinocembrin. The activities of superoxide dismutase (SOD), myeloperoxidase (MPO) and the content of malondialdehyde (MDA) in brain tissue were tested by colorimetric assays. Alterations of neurotransmitters were determined by a high performance liquid chromatography-electrochemical method.Pinocembrin significantly ameliorated neurological deficits and brain edema, and alleviated the degree of hippocampal neuronal loss at 24h after global cerebral I/R with a broad therapeutic time window. It was found that treatment with pinocembrin reduced the compensatory increase of SOD activity and decreased the MDA level and MPO activity in a dose-dependent manner. The metabolic balance between excitatory and inhibitory amino acids was modulated by pinocembrin treatment.These findings suggest that pinocembrin provides neuroprotection against global cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antioxidative, antiinflammatory and antiexcitotoxic effects.",
        "keywords": [
            "neuroprotection",
            "pinocembrin",
            "cerebral ischemia",
            "excitatory amino acids",
            "oxidative stress"
        ],
        "authors": [
            {
                "name": "Li-li Shi",
                "org": ""
            },
            {
                "name": "Bai-nian Chen",
                "org": ""
            },
            {
                "name": "Mei Gao",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Heng-ai Zhang",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Yan-jing Li",
                "org": "Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning 530022, PR China"
            },
            {
                "name": "Li Wang",
                "org": "Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning 530022, PR China"
            },
            {
                "name": "Guan-hua Du",
                "org": ""
            }
        ],
        "venue": "Life sciences",
        "year": 2011
    },
    "ycUk9MX7": {
        "id": "ycUk9MX7",
        "title": "Protective Effects of Danshen on Cerebral Vessels and the Nervous System",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "han guangliang",
                "org": "peking union medical college"
            },
            {
                "name": "yuehua wang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "hongmei guang",
                "org": "peking union medical college"
            },
            {
                "name": "xinrui cheng",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "n0MW7uUB": {
        "id": "n0MW7uUB",
        "title": "Salvianolic acid A protects human SH-SY5Y neuroblastoma cells against H₂O₂-induced injury by increasing stress tolerance ability.",
        "abstract": "Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In this study, we investigated the neuroprotective effects of Sal A in human SH-SY5Y neuroblastoma cells against H(2)O(2)-induced injury. Our results showed that cells pretreated with Sal A exhibited enhanced neuronal survival and that this protection was associated with an increase in adenosine triphosphate (ATP) and the stabilization of mitochondrial membrane potential. In addition, Sal A markedly decreased the excessive activation AMP-activated protein kinase (AMPK) and the serine-threonine protein kinase, Akt, in SH-SY5Ycells induced by H(2)O(2). In conclusion, our results demonstrated that Sal A protects SH-SY5Y cells against H(2)O(2)-induced oxidative stress and these protective effects are related to stress tolerance and not energy depletion via inhibition of the AMPK and Akt signaling pathway.",
        "keywords": [],
        "authors": [
            {
                "name": "Heng-ai Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, PR China."
            },
            {
                "name": "Mei Gao",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Yan Zhao",
                "org": ""
            },
            {
                "name": "Li-li Shi",
                "org": ""
            },
            {
                "name": "Bai-nian Chen",
                "org": ""
            },
            {
                "name": "Yue-hua Wang",
                "org": ""
            },
            {
                "name": "Shou-bao Wang",
                "org": ""
            },
            {
                "name": "Guan-hua Du",
                "org": ""
            }
        ],
        "venue": "Biochemical and biophysical research communications",
        "year": 2012
    },
    "UoR4J9le": {
        "id": "UoR4J9le",
        "title": "Asymmetric dimethylarginine confers the communication between endothelial and smooth muscle cells and leads to VSMC migration through p38 and ERK1/2 signaling cascade.",
        "abstract": "Communication between endothelial and smooth muscle cells (SMCs) contributes to atherosclerosis induced by atherogenic factors, such as oxide LDL. Asymmetric dimethylarginine (ADMA), a newly found cardiovascular risk factor, accumulates in the culture medium of oxide LDL (oxLDL)-treated endothelial cells and positively correlates with atherosclerosis. This study demonstrates that ADMA mediates the communication between endothelial cells and SMCs induced by oxLDL leading to SMC migration. In addition, the present study suggests exogenous ADMA directly induces SMC migration via p38 and ERK1/2 MAPK signaling transduction way. Investigations to identify the factors regulating VSMC migration may provide novel insights into atherosclerosis and its complications.",
        "keywords": [
            "atherosclerosis",
            "oxide ldl",
            "mapk",
            "vascular smooth muscle cell",
            "asymmetric dimethylarginine",
            "migration",
            "signal transduction",
            "endothelial cell"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Xin Yu",
                "org": "Yantai University(Yantai University),Yantai,China"
            },
            {
                "name": "Wenyu Xin",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Xi Lan",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Dan Zhang",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Chao Huang",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Guahua Du",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            }
        ],
        "venue": "FEBS letters",
        "year": 2011
    },
    "VV6icPBM": {
        "id": "VV6icPBM",
        "title": "Inclusion complexes of pinocembrin with cyclodextrin or its derivatives",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "song wu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "yan qi",
                "org": ""
            },
            {
                "name": "mei gao",
                "org": ""
            },
            {
                "name": "qingyun yang",
                "org": ""
            },
            {
                "name": "hongmei guang",
                "org": ""
            },
            {
                "name": "wei li",
                "org": ""
            },
            {
                "name": "yuehua wang",
                "org": ""
            },
            {
                "name": "yuanfeng tong",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "pd6xziYi": {
        "id": "pd6xziYi",
        "title": "Study of methyl salicylate glycosides in acute pleurisy model in rats",
        "abstract": "Aim To study the anti-inflammatory effect and mechanism of methyl salicylate glycosides(DL0309) in carrageenan-induced acute pleurisy model in rats,and to provide the pharmacology mechanism for the effects and clinical use of DL0309.Methods Forty-eight male rats were divided into 6 groups: normal group,pleurisy model group,dexamethasone group(positive drug),DL0309 low dose(150 mg·kg-1),medium dose(300 mg·kg-1),and high dose(600 mg·kg-1) groups.The acute pleurisy model was established by injecting carrageenan into chest.The rats were sacrificed after 5 h and the blood and the exudates were collected.The ELISA method was used to detect the production of TNF-α,IL-1β,PGE2 in exudates.The NO content was measured by Griess assay.The contents of malondialdehyde(MDA) and the activity of superoxide dismutase(SOD) were detected by kit instruction.Results Compared with acute pleurisy model group,DL0309 decreased the volume of exudates,the total leukocyte numbers and protein contents in exudates.Meanwhile,DL0309 could significantly reduce the levels of IL-1β and PGE2 and decrease the contents of TNF-α and NO.In addition,DL0309 was also able to decrease the contents of MDA and the activity of SOD in plasma in carrageenan-treated rats.Conclusion DL0309 has potent anti-inflammatory effects on carrageenan-induced acute pleurisy model in rats.",
        "keywords": [
            "anti-inflammation",
            "carrageenan",
            "pleurisy",
            "pro-inflammatory factor",
            "PGE2",
            "methyl salicylate glycosides"
        ],
        "authors": [
            {
                "name": "HUANG Chao",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Dan",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "XIN Wen-yu",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "LI Yong-jie",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Tian-tai",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2013
    },
    "1SEbqJu5": {
        "id": "1SEbqJu5",
        "title": "The Effects of Danshen on Respiratory Diseases and Their Mechanisms",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guorong he",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "danshen zhang",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "OE5WqufI": {
        "id": "OE5WqufI",
        "title": "Advance in the study of myocardial ischemic preconditioning and postconditioning and the clinical applications]",
        "abstract": "Myocardial ischemic preconditioning and postconditioning can reduce myocardial infarct size, improve myocardial contractility, protect coronary endothelial and myocardial cell ultrastructure, as well as reduce the incidence of arrhythmias. Clinical practice has confirmed the safety and efficacy of these two methods of myocardial protection. This paper reviewed about ischemic preconditioning and postconditioning protection mechanisms in myocardial ischemia reperfusion injury and clinical research literatures in recent years, to provide a theoretical basis for finding new treatment strategies on the prevention and treatment of ischemic cardiomyopathy.",
        "keywords": [
            "ischemia/reperfusion",
            "myocardial ischemia",
            "ischemic preconditioning",
            "ischemic postconditioning"
        ],
        "authors": [
            {
                "name": "Yu-Jie Wu",
                "org": "1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening,"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening,;2.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "1.Beijing Key Laboratory of Drug Targets Identification and Drug Screening,;2.State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2013
    },
    "OehPmtSy": {
        "id": "OehPmtSy",
        "title": "Pharmacokinetics of different nitrendipine tablets in rats",
        "abstract": "AIM: To study the pharmacokinetics of different nitrendipine tablets in rats.METHODS: An LC-MS method was established for the detection of nitrendipine in plasma after a single oral dose of 50 mg/kg nitrendipine tablets.Pharmacokinetics parameters were calculated by DAS 3.0 data-processing system.RESULTS:Determination results of the three bulk drug manufactures indicated that nitrendipine form Ⅳ had a higher absorption and bioavailability than nitrendipine form Ⅰ which was commonly used.Pharmacokinetic parameters of the 16 products selected randomly from different industries were different after a single dose of 50 mg/kg.Maximum differences of Cmax,tmax,t1/2,AUC(0-t) came up to 2.5,24.4,4.5 and 1.6 times.CONCLUSION: There are differences among the pharmacokinetics of different nitrendipine tablets in rats.Crystal form is a principal element leading to the discrepancies.",
        "keywords": [
            "Bioavailability",
            "Crystal form",
            "LC-MS",
            "Nitrendipine",
            "Pharmacokinetics"
        ],
        "authors": [
            {
                "name": "SUN Jia-lin",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Beijing ,China"
            },
            {
                "name": "SONG Jun-ke",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Beijing ,China"
            },
            {
                "name": "XING Cheng",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Beijing ,China"
            },
            {
                "name": "LV Yang",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Pharmacology and Therapeutics",
        "year": 2012
    },
    "B3d7Gt3g": {
        "id": "B3d7Gt3g",
        "title": "Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents.",
        "abstract": "Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma. In a previous article, we described the lead discovery of DL0805, a new ROCK I inhibitor, showing potent inhibitory activity (IC50 6.7 μM). Herein, we present the lead optimization of compound DL0805, resulting in the discovery of 24- and 39-fold more-active analogues 4a (IC50 0.27 μM) and 4b (IC50 0.17 μM), among other active analogues. Moreover, ex-vivo studies demonstrated that 4a and 4b exhibited comparable vasorelaxant activity to the approved drug fasudil in rat aortic rings. The research of a preliminary structure-activity relationship (SAR) indicated that the target compounds containing a β-proline moiety have improved activity against ROCK I relative to analogues bearing an α-proline moiety, and among the series of the derivatives with a β-proline-derived indazole scaffold, the inhibitory activity of the target compounds with a benzyl substituent is superior to those with a benzoyl substituent.",
        "keywords": [
            "N-substituted prolinamido indazoles",
            "Rho kinase",
            "SAR",
            "inhibitor",
            "vasorelaxant"
        ],
        "authors": [
            {
                "name": "Yangyang Yao",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. yao0943017@163.com."
            },
            {
                "name": "Renze Li",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. renze.li@open01.com."
            },
            {
                "name": "Xiaoyu Liu",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lxya@imm.ac.cn."
            },
            {
                "name": "Feilong Yang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. yangfeilong@imm.ac.cn."
            },
            {
                "name": "Ying Yang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. yangying@imm.ac.cn."
            },
            {
                "name": "Xiaoyu Li",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. pharmli@imm.ac.cn."
            },
            {
                "name": "Xiang Shi",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. xiangshi@imm.ac.cn."
            },
            {
                "name": "Tianyi Yuan",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. yuantianyi@imm.ac.cn."
            },
            {
                "name": "Lianhua Fang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. fanglh@imm.ac.cn."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. dugh@imm.ac.cn."
            },
            {
                "name": "Xiaozhen Jiao",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. jiaoxz@imm.ac.cn."
            },
            {
                "name": "Ping Xie",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. xp@imm.ac.cn."
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2017
    },
    "lAa98HyS": {
        "id": "lAa98HyS",
        "title": "Pinocembrin protects against beta-amyloid-induced toxicity in neurons through inhibiting RAGE-independent signaling pathways and regulating mitochondrion-mediated apoptosis (877.4)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "rui liu",
                "org": ""
            },
            {
                "name": "dan zhou",
                "org": ""
            },
            {
                "name": "li zhang",
                "org": ""
            },
            {
                "name": "tiantai zhang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2014
    },
    "BUmv5C7n": {
        "id": "BUmv5C7n",
        "title": "Urinary metabonomic study using a CUMS rat model of depression: Urinary metabonomic study of CUMS rat model of depression based on NMR",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaojie liu",
                "org": ""
            },
            {
                "name": "zhongfeng li",
                "org": ""
            },
            {
                "name": "xiaoxia gao",
                "org": ""
            },
            {
                "name": "yuzhi zhou",
                "org": ""
            },
            {
                "name": "haifeng sun",
                "org": ""
            },
            {
                "name": "lizeng zhang",
                "org": ""
            },
            {
                "name": "xiaoqing guo",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            }
        ],
        "venue": "Magnetic Resonance in Chemistry",
        "year": 2012
    },
    "GMSqE3uw": {
        "id": "GMSqE3uw",
        "title": "Antidiabetic Effect of Salvianolic Acid A on Diabetic Animal Models via AMPK Activation and Mitochondrial Regulation.",
        "abstract": "Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which is a traditional Chinese medicine widely used to treat cardiovascular diseases. However, little is known about its antidiabetic effect. Our study aimed to investigate the in vivo and in vitro antidiabetic effect of SalA and the underlying mechanisms.Alloxan-induced type 1 diabetic mice and high-fat diet (HFD) and low-dose streptozotocin (STZ)-induced type 2 diabetic rats received SalA treatment. Blood glucose, oral glucose tolerance test (OGTT), 24-h food and water intake were monitored. In vitro, glucose consumption and uptake were measured in HepG2 cells and L6 myotubes. Mitochondrial function was detected in hepatic and skeletal muscle mitochondria. AMP-activated protein kinase (AMPK) and Akt were analyzed by western blot.In both type 1 and type 2 diabetic animals, SalA lowered fasting blood glucose (FBG) and fed blood glucose in dose-dependent manner, as well as reduced 24-h food and water intake. In vitro, SalA caused dose-dependent increase in glucose consumption and enhanced glucose uptake. SalA significantly increased ATP production from 10 min to 12 h in HepG2 cells and L6 myotubes. Interestingly, SalA decreased mitochondrial membrane potential (MMP) in HepG2 cells. Furthermore, SalA improved hepatic and skeletal muscle mitochondrial function, increased ATP production, and concurrently decreased MMP. In particularly, SalA activated AMPK phosphorylation through Ca(2+)/calmodulin-dependent protein kinase kinase β (CaMKKβ)/AMPK signaling pathway, independent of liver kinase 1 (LKB1)/AMPK pathway. However, SalA didn't show any effect on insulin secretagogue and activation of PI3K/Akt signaling pathway.SalA exhibits the antidiabetic effects in diabetic animal models through improving mitochondrial function, increasing ATP production, and decreasing MMP via CaMKKβ/AMPK signaling pathway.",
        "keywords": [
            "mitochondria",
            "diabetes mellitus",
            "mitochondrial membrane potential"
        ],
        "authors": [
            {
                "name": "Guifen Qiang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Xiuying Yang",
                "org": ""
            },
            {
                "name": "Lili Shi",
                "org": ""
            },
            {
                "name": "Hengai Zhang",
                "org": ""
            },
            {
                "name": "Bainian Chen",
                "org": ""
            },
            {
                "name": "Yan Zhao",
                "org": ""
            },
            {
                "name": "Mian Zu",
                "org": ""
            },
            {
                "name": "Dan Zhou",
                "org": ""
            },
            {
                "name": "Jing Guo",
                "org": ""
            },
            {
                "name": "Haiguang Yang",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology",
        "year": 2015
    },
    "9zQ3uOlZ": {
        "id": "9zQ3uOlZ",
        "title": "A Translational Research for Enhanced Clinical Validity of Mouse Models of Depression",
        "abstract": "According to the World Health Organization,major depression disorder is projected to reach second place as leading contributor to the global burden of disease by the year 2020.Despite the emergency need for better therapies of depression,and major advances in the understanding of the molecular basis of this disorder in recent years,efforts to discover and develop new drugs for major depression disorder,especially those which might revolutionize disease treatment,have been relatively unsuccessful.An important reason for this is that it is exceedingly difficult to build an animal model that perfectly recapitulates the symptoms of depression in human patients.In order to enhance clinical validity of animal models of depression,we reviewed the recent animal models of depression and discussed its translational research here.",
        "keywords": [
            "Model",
            "Depression",
            "Biomarkers",
            "Translational research",
            "animal"
        ],
        "authors": [
            {
                "name": "BAI Xiao-yu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Comparative Medicine",
        "year": 2011
    },
    "nMgdUpUE": {
        "id": "nMgdUpUE",
        "title": "Research progress of salvianolic acid A]",
        "abstract": "Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the technological improvement of extraction and separation. Salvianolic acid A possessed multiple pharmacological activities, including antioxidants, myocardial ischemic protection, antithrombatic, neuroprotection, anti fibrosis, prevention of diabetes and complications. Recently, preliminary pharmacokinetics characteristics of salvianolic acid A were clarified. Based on the research literature and study work from author's laboratory, this review will focus on recent developments concerning the chemistry, pharmacology and pharmacokinetic of salvianolic acid A, and prospect further research.",
        "keywords": [
            "chemistry",
            "salvianolic acid a",
            "pharmacokinetic",
            "pharmacology"
        ],
        "authors": [
            {
                "name": "Li Zhang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Weiku Zhang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Ying Zhao",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Lianhua Fang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Shoubao Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Lili Shi",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Xiaoyan Yu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Subo Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Haiguang Yang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Jialin Sun",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Shuo Tian",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2011
    },
    "fnvrYo55": {
        "id": "fnvrYo55",
        "title": "Effect of the group of effective components of Chinese medical prescription-Xiaoxuming Decoction on aging rats",
        "abstract": "AIM: To establish the model of aging rats and observe the effect of the group of effective components of Xiaoxuming Decoction(XXM)on aging rats. METHODS: D-galactose and rotenone were used to establish aging animal model.The ability of learning and memory were measured by using Morris water maze test.Then, the content of GSH and MDA,the activity of SOD,the activity of AchE and ChAT in rats'brain were measured. (RESULTS): D-galactose could induce aging like indicators in rats:decrease the content of GSH and the activity of SOD,and increase the content of MDA,but have no effect on AchE and ChAT.It showed that GEC could improve the ability of learning and memory and ameliorate biochemistry function in rats with aging induced by D-galactose. CONCLUSION: These results suggest that GEC of XXM could improve the responses of aging rats and these effects may be related to its ability of antioxidation.",
        "keywords": [
            "Chinese medical prescription",
            "rotenone",
            "group of effective components(GEC)",
            "D-galactose",
            "aging"
        ],
        "authors": [
            {
                "name": "WANG Yue-Hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 10050,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 10050,China"
            }
        ],
        "venue": "Chinese Traditional Patent Medicine",
        "year": 2006
    },
    "9KQJFji0": {
        "id": "9KQJFji0",
        "title": "Lack of dose dependent kinetics of methyl salicylate-2-O-β-d-lactoside in rhesus monkeys after oral administration.",
        "abstract": "Methyl salicylate-2-O-β-d-lactoside (MSL) is one of the main active components isolated from Gaultheria yunnanensis, which is a traditional Chinese medicine used to treat arthritis and various aches and pains. Pharmacological researches showed that MSL had various effective activities in both in vivo and in vitro experiments. However, the pharmacokinetics features and oral bioavailability of MSL in primates were not studied up to now.To study the pharmacokinetics of different doses of MSL in rhesus monkeys and investigate the absolute bioavailability of MSL after oral administration.Male and female rhesus monkeys were either orally administrated with MSL 200, 400 and 800mg/kg or received an intravenous dose of 20mg/kg randomly. The levels of MSL and salicylic acid (SA) in plasma were simultaneous measured by a simple, sensitive and reproducible high performance liquid chromatography method.Mean peak plasma concentration values for groups treated with 200, 400 and 800mg/kg doses ranged from 48.79 to 171.83μg/mL after single-dose oral administration of MSL, and mean area under the concentration-time curve values ranged from 195.16 to 1107.76μg/mLh. Poor linearity of the kinetics of SA after oral administration of MSL was observed in the regression analysis of the Cmax-dose plot (r(2)=0.812), CL-dose plot (r(2)=0.225) and AUC(0-t)-dose plot (r(2)=0.938). Absolute bioavailability of MSL was assessed to be 118.89±57.50, 213.54±58.98 and 168.72±76.58%, respectively.Bioavailability of MSL after oral administration in rhesus monkeys was measured for the first time. Pharmacokinetics parameters did not appear to be dose proportional among the three oral doses of treatments, and MSL showed an apparent absolute bioavailability in excess of 100% in rhesus monkeys based on the present study. In addition, a rapid, sensitive and reliable HPLC method was established and demonstrated for the research of traditional Chinese medicine in this study.",
        "keywords": [
            "bioavailability",
            "hplc",
            "methyl salicylate-2-o-β-d-lactoside",
            "pharmacokinetics",
            "salicylic acid"
        ],
        "authors": [
            {
                "name": "Yangyang He",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Yu Yan",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Tiantai Zhang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Yinzhong Ma",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Wen Zhang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Ping Wu",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Junke Song",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China."
            },
            {
                "name": "Shuang Wang",
                "org": "Laboratory of Protein Engineering, Institute of Biotechnology, Chinese Academy of Military Medical Sciences, PR China."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp;amp; Peking Union Medical College, PR China. "
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2015
    },
    "GjdeaiNR": {
        "id": "GjdeaiNR",
        "title": "Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique.",
        "abstract": "This study highlights the clinical application of metabolomics in disease diagnose and therapy evaluation, which will help in improving our understanding of depression and will lay solid foundation for the clinic application of TCMs. In addition, it suggests that the combination of the two potential biomarkers had also achieved a high diagnostic value, which consequently could be used a diagnose biomarkers.",
        "keywords": [
            "Behavior",
            "Clinic metabolomics",
            "Combined biomarkers",
            "Depression",
            "GC-MS",
            "Plasmatic biomarkers",
            "Xiaoyaosan"
        ],
        "authors": [
            {
                "name": "Xiaojie Liu",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Science and Technology Innovation Team of Shanxi Province, Taiyuan, 030006, PR China; Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province, Taiyuan, 030006, PR China."
            },
            {
                "name": "Caichun Liu",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Science and Technology Innovation Team of Shanxi Province, Taiyuan, 030006, PR China; Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province, Taiyuan, 030006, PR China."
            },
            {
                "name": "Junsheng Tian",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Science and Technology Innovation Team of Shanxi Province, Taiyuan, 030006, PR China; Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province, Taiyuan, 030006, PR China."
            },
            {
                "name": "Xiaoxia Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Science and Technology Innovation Team of Shanxi Province, Taiyuan, 030006, PR China; Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province, Taiyuan, 030006, PR China."
            },
            {
                "name": "Ke Li",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Science and Technology Innovation Team of Shanxi Province, Taiyuan, 030006, PR China; Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province, Taiyuan, 030006, PR China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, PR China; Science and Technology Innovation Team of Shanxi Province, Taiyuan, 030006, PR China; Key Laboratory of Effective Substances Research and Utilization in Traditional Chinese Medicine of Shanxi Province, Taiyuan, 030006, PR China. Electronic address: qinxm@sxu.edu.cn."
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2019
    },
    "6Vw3TfrN": {
        "id": "6Vw3TfrN",
        "title": "Prevention of vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia by CREB-mediated p21 induction: An insight from a plant polyphenol.",
        "abstract": "Cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/cAMP response element (CRE)-binding protein (CREB) signaling cascade negatively regulates platelet-derived growth factor BB (PDGF-BB)-induced smooth muscle cell (SMC) proliferation, which is a critical event in the initiation and development of restenosis and atherosclerotic lesions. Salvianolic acid A (SAA) is one of the most abundant polyphenols extracted from salvia. The aim of this study is to investigate whether SAA exerts an action on PDGF-BB-induced proliferation via cAMP/PKA/CREB mechanism. SAA blunts PDGF-BB-induced human umbilical artery smooth muscle cell (hUASMC) proliferation via p21 induction, as evidenced by its increased mRNA and protein expression levels. The SAA-induced upregulation of p21 involves the cAMP/PKA signaling pathway; a cAMP analog mimicked the effects of SAA and a specific cAMP/PKA inhibitor opposed these effects. SAA also activated CREB, including phosphorylation at Ser133, and induced its nuclear translocation. Deletion and mutational analysis of p21 promoters, co-immunoprecipitation, and western blot analysis showed that CRE is essential for SAA-induced p21 protein expression. Transfection of dominant-negative CREB (mutated Ser133) plasmids into hUASMCs attenuated SAA-stimulated p21 expression. SAA upregulated p21 expression and activated CREB in the neointima of balloon-injured arteries in vivo. Our results indicate that SAA promotes p21 expression in SMCs through the cAMP/PKA/CREB signaling cascade in vitro and prevents injury-induced neointimal hyperplasia.",
        "keywords": [
            "Cell Proliferation",
            "Cyclin-dependent Kinase Inhibitor p21",
            "Polyphenols",
            "Vascular remodeling",
            "cAMP response element-binding protein (CREB)"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            },
            {
                "name": "Rui Zhao",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            },
            {
                "name": "Li Zhang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            },
            {
                "name": "Weiku Zhang",
                "org": "Department of Pharmacology, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China."
            },
            {
                "name": "GuoRong He",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            },
            {
                "name": "Shengqian Yang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            },
            {
                "name": "Junke Song",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing 100050, People's Republic of China."
            }
        ],
        "venue": "Biochemical pharmacology",
        "year": 2016
    },
    "8hkzRxoH": {
        "id": "8hkzRxoH",
        "title": "Salvianolic acid A inhibits PDGF-BB induced vascular smooth muscle cell migration and proliferation while does not constrain endothelial cell proliferation and nitric oxide biosynthesis.",
        "abstract": "Proliferation and migration of vascular smooth muscle cells (VSMCs) are critical events in the initiation and development of restenosis upon percutaneous transluminal coronary angioplasty (PTCA). Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Salvianolic A (SalA) is one of the most abundant polyphenols extracted from salvia. In this study, we investigated the effect of salvianolic A (SalA) on the migration and proliferation of VSMCs. We found a preferential interaction of SalA with cellular systems that rely on the PDGF signal, but not on the EGF and bFGF signal. SalA inhibits PDGF-BB induced VSMC proliferation and migration in the concentration range from 0.01 to 0.1 μM. The inhibition of SalA on VSMC proliferation is associated with cell cycle arrest. We also found that SalA inhibits the PDGFRβ-ERK1/2 signaling cascade activated by PDGF-BB in VSMCs. In addition, SalA does not influence the proliferation of endothelial cells, the synthesis of NO and eNOS protein expression. Our results suggest that SalA inhibits migration and proliferation of VSMCs induced by PDGF-BB via the inhibition of the PDGFRβ-ERK1/2 cascade, but that it does not constrain endothelial cell proliferation and nitric oxide biosynthesis. Thus, the present study suggests a novel adjunct pharmacological strategy to prevent angioplasty-related restenosis.",
        "keywords": [
            "migration"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Tiantai Zhang",
                "org": ""
            },
            {
                "name": "Wenyu Xin",
                "org": ""
            },
            {
                "name": "Xi Lan",
                "org": ""
            },
            {
                "name": "Chao Huang",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2012
    },
    "3Agridbb": {
        "id": "3Agridbb",
        "title": "Polymorphism and Pharmacokinetic Research of Ribavirin",
        "abstract": "OBJECTIVE To establish the preparation method and detection technology of ribavirin polymorphism,and to estimate the bioavailability differences among the ribavirin polymorphs.METHODS Through polymorphism screening,ribavirin crystals of the form A,B,C,D were obtained.The crystal forms of ribavirin were characterized by different analysis methods,such as single crystal X-ray diffraction method(SXRD),powder X-ray diffraction method(PXRD),differential scanning calorimetry method(DCS),infrared spectrum method(IR) and melting point method(MP);solid ribavirin in different forms were orally administered to rats,and an HPLC-MS method was established to determine the plasma levels of ribavirin,and the bioavailability was analyzed.RESULTS Of the four polymorphs of ribavirin,form C and form D were reported for the first time.The four polymorphic forms all could be identified by PXRD,DSC,IR and MP.The ρmax and AUC0-t of form A were superior to those of the other forms.CONCLUSION Characteristic data for ribavirin polymorphism are obtained;and form A of ribavirin is a suitable medicinal crystal.This study has provided the basis for choice of medicinal crystal and the improvement of quality standards.",
        "keywords": [
            "crystal analysis method",
            "polymorphism",
            "ribavirin",
            "bioavailability"
        ],
        "authors": [
            {
                "name": "XING Cheng",
                "org": "Peking Union Medical College,Institute of Materia Medica & Chinese Academy of Medical Sciences,Research Centre of Polymorphic Drugs,Beijing Key Laboratory of Polymorphic Drug,Beijing ,China"
            },
            {
                "name": "SONG Jun-ke",
                "org": "Peking Union Medical College,Institute of Materia Medica & Chinese Academy of Medical Sciences,Beijing Key Laboratory of Drug Targets and Screening Research,Beijing ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Peking Union Medical College,Institute of Materia Medica & Chinese Academy of Medical Sciences,Research Centre of Polymorphic Drugs,Beijing Key Laboratory of Polymorphic Drug,Beijing ,China"
            },
            {
                "name": "YANG Shi-ying",
                "org": "Peking Union Medical College,Institute of Materia Medica & Chinese Academy of Medical Sciences,Research Centre of Polymorphic Drugs,Beijing Key Laboratory of Polymorphic Drug,Beijing ,China"
            },
            {
                "name": "SHI Yong-qiang",
                "org": "Shandong Yikang Pharmaceutical Co.,Ltd.,Shandong Key Laboratory of Polymorphic Drug,Tengzhou ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Peking Union Medical College,Institute of Materia Medica & Chinese Academy of Medical Sciences,Beijing Key Laboratory of Drug Targets and Screening Research,Beijing ,China"
            },
            {
                "name": "Lü Yang",
                "org": "Peking Union Medical College,Institute of Materia Medica & Chinese Academy of Medical Sciences,Research Centre of Polymorphic Drugs,Beijing Key Laboratory of Polymorphic Drug,Beijing ,China;Shandong Yikang Pharmaceutical Co.,Ltd.,Shandong Key Laboratory of Polymorphic Drug,Tengzhou ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2013
    },
    "TfkBVrWX": {
        "id": "TfkBVrWX",
        "title": "Association of tissue plasminogen activator and plasminogen activator inhibitor polymorphism with myocardial infarction: a meta-analysis.",
        "abstract": "To investigate whether t-PA Alu repeat insertion/deletion (I/D) and PAI-1 4G/5G genetic variations are associated with the risk of MI.We conducted a meta-analysis to assess the association between the t-PA I/D and PAI-1 4G/5G polymorphisms and risk of MI. We also performed subgroup analyses based on ethnicity (Caucasian, Asian, and African), gender and age. Forty one eligible studies including 12,461 cases and 14,993 controls were identified to evaluate the impact of PAI-1 4G/5G polymorphism on MI. Seven studies investigated the relationship between t-PA I/D and MI.This meta-analysis revealed that the PAI-1 4G allele (4G/4G and 4G/5G genotype) was associated with an increased risk of MI compared with the 5G allele in the overall population (OR=1.094, 95% CI=1.021 - 1.172, p=0.011). The relative risks of MI for 4G/4G genotype was increased when compared to 5G/5G genotype and 5G allele, with odds ratio at 1.157 (95% CI 1.015 - 1.320, p=0.029) and 1.126 (95% CI =1.015 - 1.249, p=0.025). However, the results show that the 4G/5G polymorphism risk for MI was not associated with ethnicity stratification as Caucasian, Asian or African population. No substantial differences in the genotype distributions were observed in the MI group and control group along the lines of gender and age. After multivariable analysis t-PA I/D polymorphism showed no consistent association with MI.This study suggests that the 4G/5G polymorphism of PAI-1 may be a risk factor for MI in overall populations.",
        "keywords": [
            "plasminogen activator inhibitor-1",
            "myocardial infarction",
            "ttissue plasminogen activator",
            "polymorphism",
            "meta-analysis",
            "meta analysis"
        ],
        "authors": [
            {
                "name": "Li-Li Gong",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Jian-Hao Peng",
                "org": "Cleveland Clinic Foundation(Cleveland Clinic Foundation,Cleveland Clinic),Cleveland,United States"
            },
            {
                "name": "Fei-Fei Han",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Jin Zhu",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yue-Hua Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "He-Yao Wang",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Li-Hong Liu",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            }
        ],
        "venue": "Thrombosis research",
        "year": 2012
    },
    "poaqMhl9": {
        "id": "poaqMhl9",
        "title": "Study of the anti-atherosclerotic mechanism of vitisin",
        "abstract": "Aim To elucidate the anti-atherosclerotic mechanism of vitisinA and didehydro-vitisinA from Vitis amurensis.Methods After the human endothelial cell Hy926,monocyte derived THP-1 macrophage and mouse macrophage RAW264.7 were damaged by oxLDL and LPS in vitro,the effects of the two test compounds were observed on cell viability by MTT reduction and LDH activity assay,the release of ROS and NO,the content of MDA,the activity of SOD,the secretion of inflammatory cytokines TNF-α and IL-1β,and the cell adhesion of THP-1 monocyte and endothelial cell Hy926.Results The two compounds produced marked effects on protecting cells from injury,reducing the production of free radicals and the secretion of inflammatory cytokines,antioxcidation,and inhibiting the cell adhesion of monocyte and endothelial cells.Conclusions It is observed that vitisinA and didehydro-vitisinA can regulate factors which were important in the initiation and early progression of atherosclerosis,and their possible anti-atherosclerosis mechanism may be involved in multiple pathways.",
        "keywords": [
            "endothelial cell",
            "ox-LDL",
            "vitisin",
            "adhesion",
            "macrophage",
            "atherosclerosis"
        ],
        "authors": [
            {
                "name": "LI Shao-jing",
                "org": ""
            },
            {
                "name": "HUANG Feng",
                "org": ""
            },
            {
                "name": "LAN Xi",
                "org": ""
            },
            {
                "name": "DU Guan-hua",
                "org": ""
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2010
    },
    "w0ctB5zV": {
        "id": "w0ctB5zV",
        "title": "The obesity-induced transcriptional regulator TRIP-Br2 mediates visceral fat endoplasmic reticulum stress-induced inflammation.",
        "abstract": "The intimate link between location of fat accumulation and metabolic disease risk and depot-specific differences is well established, but how these differences between depots are regulated at the molecular level remains largely unclear. Here we show that TRIP-Br2 mediates endoplasmic reticulum (ER) stress-induced inflammatory responses in visceral fat. Using in vitro, ex vivo and in vivo approaches, we demonstrate that obesity-induced circulating factors upregulate TRIP-Br2 specifically in visceral fat via the ER stress pathway. We find that ablation of TRIP-Br2 ameliorates both chemical and physiological ER stress-induced inflammatory and acute phase response in adipocytes, leading to lower circulating levels of inflammatory cytokines. Using promoter assays, as well as molecular and pharmacological experiments, we show that the transcription factor GATA3 is responsible for the ER stress-induced TRIP-Br2 expression in visceral fat. Taken together, our study identifies molecular regulators of inflammatory response in visceral fat that-given that these pathways are conserved in humans-might serve as potential therapeutic targets in obesity.",
        "keywords": [
            "Biological sciences",
            "Cell biology",
            "Medical research"
        ],
        "authors": [
            {
                "name": "Guifen Qiang",
                "org": "Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Avenue, M/C901, MSB E-202, Chicago, 60612 Illinois, USA."
            },
            {
                "name": "Hyerim Whang Kong",
                "org": "Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Avenue, M/C901, MSB E-202, Chicago, 60612 Illinois, USA."
            },
            {
                "name": "Difeng Fang",
                "org": "Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, 10 Center Drive, Bethesda, 20892 Maryland, USA."
            },
            {
                "name": "Maximilian McCann",
                "org": "Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Avenue, M/C901, MSB E-202, Chicago, 60612 Illinois, USA."
            },
            {
                "name": "Xiuying Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Matthias Blüher",
                "org": "Department of Medicine, University of Leipzig, Liebigstrasse 18, Leipzig 04103, Germany."
            },
            {
                "name": "Jinfang Zhu",
                "org": "Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIH, 10 Center Drive, Bethesda, 20892 Maryland, USA."
            },
            {
                "name": "Chong Wee Liew",
                "org": "Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, 835 S. Wolcott Avenue, M/C901, MSB E-202, Chicago, 60612 Illinois, USA."
            }
        ],
        "venue": "Nature Communications",
        "year": 2016
    },
    "7uqTSHX0": {
        "id": "7uqTSHX0",
        "title": "Effects of the active components of Chinese herbal medicine Xiaoxuming Decoction on memory behavior and brain injury in rats with chronic cerebral ischemia]",
        "abstract": "To study the effects of the active components of Xiaoxuming Decoction (XXM), a compound traditional Chinese herbal medicine, on chronic cerebral ischemia in rats.Chronic cerebral ischemia was induced in rats by occlusion of bilateral common carotid arteries. Then, the rats with chronic cerebral ischemia were randomly divided into five groups: model group, extract of Ginkgo biloba group and low-, medium- and high-dose active components of XXM groups. Another 11 rats without occlusion of common carotid arteries were used as the sham-operation group. Memory behavior was investigated by Morris water maze test. The structure of hippocampus and cortex neurons was observed with Nissel staining. The white matter lesion was stained with Klüver-Barrera stain method to observe the pathological changes. The astrocyte activation was observed using immunohistochemical method with glial fibrillary acidic protein (GFAP) antibody.The active components of XXM could significantly improve the impairment of learning and memory induced by chronic cerebral ischemia in rats. Compared with the model group, the time to reach the platform for rats was shortened by treating with the active components of XXM in Morris water maze test, particularly in the medium-dose group (P<0.05). In addition, the low- and medium-dose active components of XXM improved the decrease of cerebrovascular reactivity induced by chronic cerebral ischemia. The results of the pathological analysis also suggested that the active components of XXM could ameliorate the pathological damage induced by chronic cerebral ischemia in rats with the number of neurons increased, and the morphology and distribution of neurons recovered to normal levels. The low-dose active components of XXM significantly reduced the white matter lesions (P<0.05, P<0.01). Active components of XXM treatment could also reduce the activation of astrocytes.The active components of XXM may attenuate the chronic cerebral ischemic injury in rats.",
        "keywords": [
            "rats",
            "glial fibrillary acidic protein",
            "hypoxia-ischemia",
            "pathology",
            "behavioral research",
            "brain",
            "plant extracts"
        ],
        "authors": [
            {
                "name": "Yue-hua Wang",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Xiao-li He",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Hai-guang Yang",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Hai-lin Qin",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Guan-hua Du",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            }
        ],
        "venue": "Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine",
        "year": 2012
    },
    "yu8ZS3FU": {
        "id": "yu8ZS3FU",
        "title": "Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment.",
        "abstract": "The rapid evolution of influenza virus makes antiviral drugs less effective, which is considered to be a major bottleneck in antiviral therapy. The key proteins in the host cells, which are related with the replication cycle of influenza virus, are regarded as potential drug targets due to their distinct advantage of lack of evolution and drug resistance. Cdc2-like kinase 1 (CLK1) in the host cells is responsible for alternative splicing of the M2 gene of influenza virus during influenza infection and replication. In this study, we carried out baculovirus-mediated expression and purification of CLK1 and established a reliable screening assay for CLK1 inhibitors. After a virtual screening of CLK1 inhibitors was performed, the activities of the selected compounds were evaluated. Finally, several compounds with strong inhibitory activity against CLK1 were discovered and their in vitro anti-influenza virus activities were validated using a cytopathic effect (CPE) reduction assay. The assay results showed that clypearin, corilagin, and pinosylvine were the most potential anti-influenza virus compounds as CLK1 inhibitors among the compounds tested. These findings will provide important information for new drug design and development in influenza treatment, and CLK1 may be a potent drug target for anti-influenza drug screening and discovery.",
        "keywords": [
            "CLK1 inhibitor",
            "CPE assay",
            "baculovirus coinfection",
            "influenza A virus",
            "protein expression and purification",
            "rational screening"
        ],
        "authors": [
            {
                "name": "Mian Zu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China. zumian@ihep.ac.cn."
            },
            {
                "name": "Chao Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China. lichao880919@imm.ac.cn."
            },
            {
                "name": "Jian-Song Fang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China. fangjiansong0815@163.com."
            },
            {
                "name": "Wen-Wen Lian",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China. lianwenwen1989@imm.ac.cn."
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China. liuailin@imm.ac.cn."
            },
            {
                "name": "Li-Shu Zheng",
                "org": "National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. zhenglishu2000@sina.com."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100050, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2015
    },
    "XCGsa8Dg": {
        "id": "XCGsa8Dg",
        "title": "The vasorelaxant mechanisms of a Rho kinase inhibitor DL0805 in rat thoracic aorta.",
        "abstract": "Rho-kinase has been suggested as a potential therapeutic target in the treatment of cardiovascular diseases. The Rho-kinase signaling pathway is substantially involved in vascular contraction. The aim of the present study was to evaluate the vasorelaxant effects of Rho kinase inhibitor DL0805 in isolated rat aortic rings and to investigate its possible mechanism(s). It was found that DL0805 exerted vasorelaxation in a dose-dependent manner in NE or KCl-induced sustained contraction and partial loss of the vasorelaxation under endothelium-denuded rings. The DL0805-induced vasorelaxation was significantly reduced by the nitric oxide synthase inhibitor N(ω)-nitro-L-arginine methyl ester, the guanylate cyclase inhibitor methylene blue and the cyclooxygenase inhibitor indomethacin. The voltage-dependent K⁺ channel blocker 4-aminopyridine remarkably attenuated DL0805-induced relaxations. However, the ATP-sensitive K⁺ channel blocker glibenclamide and Ca²⁺-activated K⁺ channel blocker tetraethylammonium did not affect the DL0805-induced relaxation. In the endothelium-denuded rings, DL0805 also reduced NE-induced transient contraction and inhibited contraction induced by increasing external calcium. These findings suggested that DL0805 is a novel vasorelaxant compound associated with inhibition of Rho/ROCK signaling pathway. The NO-cGMP pathway may be involved in the relaxation of DL0805 in endothelium-intact aorta. The vasorelaxant effect of DL0805 is partially mediated by the opening of the voltage-dependent K⁺ channels.",
        "keywords": [
            "aorta",
            "dl0805",
            "endothelium",
            "vasorelaxation",
            "rho kinase",
            "nitric oxide"
        ],
        "authors": [
            {
                "name": "Lili Gong",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jianhao Peng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Lianhua Fang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Ping Xie",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Kun Si",
                "org": "Case Western Reserve University(Case Western Reserve University),Cleveland,United States"
            },
            {
                "name": "Xiaozhen Jiao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Liping Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2012
    },
    "CWMCF0MI": {
        "id": "CWMCF0MI",
        "title": "Salvianolic acid A regulates hyperlipidemia in high-fat fed rats and protects against free fatty acid-induced endothelial cell injury",
        "abstract": "Objective: Salvianolic acid A is a main efficacious water-soluble active constituent of Salvia miltiorrhiza Bunge, in this study we investigated the effects of salvianolic acid A on blood lipid levels in high-fat diet-fed rats, and on free fatty acid (FFA)-induced endothelial injury. Methods: Hyperlipidemia was induced by feeding a high-fat diet in male Spargue-Dawley rats. One month after modeling, hyperlipidemic rats were intraperitoneally given with salvianolic acid A 0.5 and 1.5 mg·kg-1 daily, and its effect on plasma lipid levels was determined. FFA-induced cell injury model was employed to evaluate the protective effect of salvianolic acid A in endothelial cells. Results: After 2-week administration, the levels of total cholesterol and low-density lipoprotein cholesterol were significantly decreased in salvianolic acid A-treated rats compared with control hyperlipidemic rats. Salvianolic acid A showed a protective effect on endothelial cell injury induced by FFA. Conclusion: Salvianolic acid A has blood lipid-regulating effect in hyperlipidemic rats, and may protect against hyperlipidemia-induced endothelial injury.",
        "keywords": [
            "Endothelial cell",
            "Free fatty acid",
            "Hyperlipidemia",
            "Rats",
            "Salvianolic acid A"
        ],
        "authors": [
            {
                "name": "YANG Xiu-ying",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "QIANG Gui-fen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "GONG Li-li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "FANG Lian-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2013
    },
    "A9NrgWkC": {
        "id": "A9NrgWkC",
        "title": "Hypocholesterolemic effect of stilbene extract from Cajanus cajan L. on serum and hepatic lipid in diet-induced hyperlipidemic mice]",
        "abstract": "Cajanus cajan L. is a natural plant, which contains a lot of potential active components. In the present study, we identified the effects of the stilbene extract from Cajanus cajan L. (sECC) on hepatic cholesterol metabolism in diet-induced (for 4 weeks) hyperlipidemic Kunming mice. All experimental mice were divided into 5 groups: control group, high lipid model group, sECC-treated with 200 or 100 mg kg(-1), and simvastatin (Sim, 12 mg kg(-1)) treated group. The mice were fed with fat and cholesterol-enriched chow except control mice that were fed with standard diet. The effects of sECC were investigated by monitoring serum and liver lipid profile (i. e. cholesterol homeostasis) in mice. To further explore the mechanism of sECC, hepatic cholesterol 7alpha-hydroxylase (CYP7A1) and low density lipoprotein (LDL) receptor expressions in cholesterol homeostasis were analyzed by reverse transcription PCR. After 4 weeks pretreatment, the mice in the high lipid model group showed markedly higher serum and hepatic lipid contents than control group (P< 0.01). Compared with high lipid model group, the increased serum and hepatic lipid contents were markedly attenuated by sECC (200 mg kg(-1)), the serum and hepatic total cholesterol were reduced by 31.5% and 22.7% (P<0.05), respectively. The triglyceride contents of serum and liver were also lowered by 23.0% and 14.4%, respectively. At the same times, serum LDL cholesterol decreased by 53.0% (P<0.01). The mRNA expressions of hepatic CYP7A1 and LDL-receptor were significantly enhanced in the mice administered with sECC (200 mg kg(-1)), whereas those expressions were suppressed by the fat and cholesterol-enriched diet. These data indicate that sECC reduces the atherogenic properties of dietary cholesterol in mice. It is indicated that expression enhancement of hepatic LDL-receptor and cholesterol 7alpha-hydroxylase may be responsible for the hypercholesterolemic effect.",
        "keywords": [
            "Cholesterol",
            "Hepatic CYP7A1",
            "Hepatic LDL-receptor",
            "Stilbene extract from Cajanus cajan L"
        ],
        "authors": [
            {
                "name": "Qing-Feng Luo",
                "org": "Institute of Basic Medical Sciences Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences,Institute of Basic Medical Sciences ^),Beijing,China"
            },
            {
                "name": "Lan Sun",
                "org": " School of Basic Medicine, Peking Union Medical College, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Jian-Yong Si",
                "org": " Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Di-Hua Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing , China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2008
    },
    "4aHqeRyt": {
        "id": "4aHqeRyt",
        "title": "Progress in the research of amorphous pharmaceuticals]",
        "abstract": "Amorphous is a special physical state of solid compounds that the positions of the molecules or atoms have no long-range order. Sometimes amorphous compounds have better bioavailability, or achieve ultra-fast absorption in situation of acute and intermittent symptoms than that of morphous compounds, thus change drug efficacy. Besides, different pharmaceutical preparing methods can lead to different characters. Research of amorphous compounds has been a hotspot, both in research field and industry world. However, there are challenges as amorphous compounds could be unstable; unexpected adverse drug reactions may also exist. In this review, recent progress in the research of amorphous pharmaceutical compounds both in the research field and the pharmaceutical industry is reviewed. Factors which can influence the efficacy of amorphous pharmaceuticals are summarized. The prospect of amorphous techniques is also discussed.",
        "keywords": [
            "pharmaceutical preparation",
            "drug efficacy",
            "drug absorption",
            "amorphous"
        ],
        "authors": [
            {
                "name": "Jian Ying",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Yang Lü",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2009
    },
    "wPYZYTQE": {
        "id": "wPYZYTQE",
        "title": "A new target of cancer therapy:advances in the study of histone deacetylase",
        "abstract": "",
        "keywords": [
            "histone acetylase",
            "active site",
            "histone deacetylase",
            "nucleosome",
            "active channel"
        ],
        "authors": [
            {
                "name": "DU Guan-hua",
                "org": "* (Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China)"
            }
        ],
        "venue": "Acta Pharmaceutica Sinica",
        "year": 2005
    },
    "62zqTzHA": {
        "id": "62zqTzHA",
        "title": "The interaction between C5aR,C5L2 and chemotaxis inhibitory protein secreted by Staphylococcus aureus",
        "abstract": "Objective To investigate the mutual effect between G protein-coupled receptors(GPCR) including C5a receptor(C5aR),C5a like receptor 2(C5L2) and chemotaxis inhibitory protein(CHIPs) secreted by Staphylococcus aureus.Methods The purified CHIPs was incubated with HEK 293T cells overexpressing C5aR,C5L2 and C-X-C chemokine receptor type 3(CXCR3).Binding signal was detected by Western blot.Results HEK 293T cells overexpressing C5aR can efficiently bind to CHIPs.No apparent relation between CHIPs and C5L2 or CXCR3 was identified.Conclusion C5aR but not C5L2 is a membrane receptor for binding CHIPs,suggesting a difference between C5aR and C5L2 in association with binding CHIPs.",
        "keywords": [
            "C5L2",
            "interaction",
            "C5aR",
            "CHIPs"
        ],
        "authors": [
            {
                "name": "LIU Zhen-jia",
                "org": "Dept.of Respiration,PUMC Hospital,CAMS & PUMC,Beijing "
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medical,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "GONG Li-li",
                "org": "Institute of Materia Medical,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "GAO Jin-ming",
                "org": "Dept.of Respiration,PUMC Hospital,CAMS & PUMC,Beijing "
            }
        ],
        "venue": "Basic & Clinical Medicine",
        "year": 2010
    },
    "JaeViQZI": {
        "id": "JaeViQZI",
        "title": "Control over Polymorph Formation of Polydatin in Binary Solvent System and Structural Characterization",
        "abstract": "Polydatin is a natural product used for anti-oxidant, anti-inflammatory and anti-tumor purposes, and often added in medicine, nutraceutical, cosmetics, and dietary supplement. Polymorphism is a key feature of solid-state pharmaceutical products. Polymorphic modifications may exhibit different physical and chemical properties. Here we report two different polymorphs, and the amorphous form of Polydatin. Polymorphs were prepared in binary solvent system. The crystal structures of the two forms were revealed for the first time. The structure and 3D packing were determined with single crystal X-ray diffraction analysis. The batch consistency and stability were identified with Powder X-ray diffraction analysis. Various functional groups present in the polymorphs were analyzed with fourier transform infrared spectroscopic method. The thermal properties were investigated with DSC and TGA. HPLC-MS was used for the pharmacokinetic study. Results show that form B has the faster absorption, and can be maintained in animal bodies for a longer time than form A.",
        "keywords": [
            "Characterization",
            "Pharmacokinetic study",
            "Polydatin",
            "Polymorphism",
            "X-ray diffractometry"
        ],
        "authors": [
            {
                "name": "Ningbo Gong",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Xue Wang",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Ying Wang",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Shiying Yang",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Junke Song",
                "org": "Beijing City Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing, 100050, China."
            },
            {
                "name": "Yang Lu",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: luy@imm.ac.cn."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing City Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing, 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Journal of pharmaceutical and biomedical analysis",
        "year": 2020
    },
    "tandYpjx": {
        "id": "tandYpjx",
        "title": "Absorption of risperidone polymorphs administrated orally in rats",
        "abstract": "OBJECTIVE: To study the gastrointestinal absorption process of risperidone polymorphs in SD rats thus to find out the optimal crystal form and explore the factors that may affect the clinical effects of risperidone. METHODS: Each rat was intragastrical-ly given one of three crystal forms of risperidone. The concentrations of resperidone in plasma were determined by HPLC method. The pharmacokinetics parameters were calculated and compared among polymorphs. RESULTS: The main pharmacokinetic parameters of risperidone form I, II and M were as follows: ρ max were (2.93 ± 1.37), (2.24 ± 1.04) and (2.02 ± 1.52) mg · L -1; t max were (1.17 ± 0.80), (1.83 ± 1.18) and (4.33 ± 2.05) h; AUC 0→t were (5.81 ± 2.10), (5.22 ± 1.78) and (6.15 ± 4.25) mg · h · L -1; t 1/2 were (0.71 ± 0.11), (0.76 ± 0.21) and (1.20 ± 0.78) h, respectively. CONCLUSION: Risperidone form I reaches peak concentration first and has the highest peak concentration. Form III is absorbed slowly, but its plasma concentration is maintained for a long time.",
        "keywords": [
            "risperidone",
            "polymorphs",
            "pharmacokinetics",
            "HPLC"
        ],
        "authors": [
            {
                "name": "SUN Jia-lin",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "CHEN Qian-xi",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "TIAN Shuo",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Fanrui Meng",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LV Yang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2011
    },
    "GwGXH9bU": {
        "id": "GwGXH9bU",
        "title": "Clinical evaluation of prescription salvia miltiorrhiza and ginkgo biloba in treating hyperlipemia",
        "abstract": "AIM: To compare the curative effect of simvastatin,xuezhikang and prescription of salvia miltiorrhiza and ginkgo biloba(SMGB) in hyperlipemia.METHODS: Three hundred and ten patients with hyperlipemia were randomly divided into four groups.Patients in the placebo group(n=30) were administered 2 capsules thrice daily.Patients in simvastatin group(n=50) were given 20 mg of the drug at bed time.Patients in xuezhikang group(n=50) were administered 2 capsules of the drug twice daily.Patients in the prescription of SMGB group(n=180) received 2 tablets of the drug twice daily.The course of treatment in each of the 4 groups lasted 12 weeks.Seventy patients in the prescription of SMGB group were treated for 24 weeks.RESULTS: Of one hundred and eighty patients in the prescription of SMGB group,total cholesterol(TC) and triglyceride(TG) were decreased significantly.Low-density lipoprotein(LDL-C) was decreased similarly compared to the other two groups.High-density lipoprotein(HDL-C) was elevated as treatment time was prolonged.CONCLUSION: The prescription of SMGB has curative effect and safety comparable to xuezhikang and simvastatin.The side effects were minimal even after treatment with prescription of SMGB for half a year.",
        "keywords": [
            "lipid treatment",
            "hyperlipemia",
            "simvastatin",
            "salvia miltiorrhiza and ginkgo biloba",
            "xuezhikang"
        ],
        "authors": [
            {
                "name": "HE Guo-rong",
                "org": ""
            },
            {
                "name": "QI Bei",
                "org": ""
            },
            {
                "name": "YU Li-ping",
                "org": ""
            },
            {
                "name": "HU Wen-li",
                "org": ""
            },
            {
                "name": "DU Guan-hua",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Clinical Pharmacology and Therapeutics",
        "year": 2006
    },
    "2y7GLjKY": {
        "id": "2y7GLjKY",
        "title": "Electrophysiological effects of pinocembrin on Aplysia SN/L7 co-cultures",
        "abstract": "Aim To study the neural electrophysiological effects of pinocembrin(PNCB) on Aplysia sensory/motor neuron co-cultures.Methods Isolated Aplysia sensory neuron(SN) and motor neuron(L7) were co-cultured for up to 5 days.At Day 5,SN/L7 was incubated with PNCB for 5 min.Excited postsynaptic potential(EPSP) was recorded immediately before and after PNCB treatment,as well as 1 h and 24 h after the removal of PNCB from the culture dish.0.005 mmol·L-1 serotonin was added to culture dishes in another set of experiment with or without the removal of PNCB,to examine the possible effect of PNCB on serotonin(5-HT) induced synaptic facilitation in sensorimotor connections.Results PNCB incubation effectively reduced the EPSP amplitude of Aplysia SN/L7 co-cultures.Linear relationship between PNCB concentration and EPSP amplitude could be established when PNCB concentration was between 0.01~0.1 mmol·L-1 or 0.1~0.4 mmol·L-1,respectively,going in opposite directions,i.e.the least repressing effect was observed when PNCB concentration was 0.1 mmol·L-1.Also observed was that incubation with 0.01 mmol·L-1 PNCB inhibited 5-HT induced synaptic facilitation.However,no effect was detected when 5-HT was applied after removal of PNCB.Conclusions PNCB reversibly represses the signal transduction at SN/L7 synapses,and reversibly inhibits 5-HT induced SN/L7 synaptic facilitation.Possible mechanism can be attributed to the complicated effects of PNCB towards pre-and post-synaptic ion channels.",
        "keywords": [
            "serotonin",
            "glutamate receptor",
            "EPSP",
            "pinocembrin",
            "SN/L7",
            "Aplysia"
        ],
        "authors": [
            {
                "name": "YING Jian",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "HU Jiang-yuan",
                "org": "Dept of Neuroscience,Columbia University College of Physicians and Surgeons,New York,NY 10032,USA"
            },
            {
                "name": "CHEN Yang",
                "org": "Dept of Neuroscience,Columbia University College of Physicians and Surgeons,New York,NY 10032,USA"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Center for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2011
    },
    "VajnOpsB": {
        "id": "VajnOpsB",
        "title": "Pharmacokinetic study of baicalein after oral administration in monkeys.",
        "abstract": "Baicalein, a flavonoid originally isolated from the root of Scutellaria baicalensis Georgi, has numerous pharmacological activities. Up to now, several studies regarding the pharmacokinetic profiles of baicalein have been described, while there is no such study reported in monkey, the species which is more similar to human. The purpose of this study was to investigate the pharmacokinetic profiles of baicalein after oral administration in monkeys. After orally administrating three doses of baicalein in monkeys, multi-peaks of the plasma concentration-time curves were observed and the non-linear pharmacokinetics for baicalein and its metabolite baicalin were found at doses of 50-500mg/kg. In order to calculate the absolute bioavailability, the intravenous pharmacokinetic study was also carried out after intravenous administration of 10mg/kg baicalein. The absolute bioavailability of baicalein in different doses was ranged from 13.1% to 23.0%. In this study, baicalein and baicalin were determined by LC-MS method. The chromatographic separation was performed on Agilent Poroshell 120 SB-C18 column (2.7μm, 2.1×50mm). Baicalein and baicalin were detected by single quadrupole mass spectrometer equipment with electrospray ionization interface with the selected ion monitoring mode. The assay was linear for both baicalein and baicalin with the correlation coefficients>0.99. The intra- and inter-day precisions for baicalein and baicalin were all less than 15% by relative standard deviation. The analytes were stable during samples storage and handling, and no matrix effects were observed. The method we developed in this study was sensitive, precise, stable and producible.",
        "keywords": [
            "pharmacokinetics",
            "baicalein",
            "monkey plasma",
            "lc-ms",
            "baicalin",
            "lc ms"
        ],
        "authors": [
            {
                "name": "Shuo Tian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guorong He",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Junke Song",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Subo Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Wenyu Xin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dan Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Fitoterapia",
        "year": 2012
    },
    "Y91lbJXh": {
        "id": "Y91lbJXh",
        "title": "Advance in high-throughput drug screening techniques targeting G protein-coupled receptors",
        "abstract": "G protein-coupled receptors(GPCRs) are important drug targets,which have been widely used in clinical practice.New assay techniques for high-throughput screening of drugs targeting GPCRs are emerging in large numbers nowadays,providing the possibility to discover the more efficient,higher selective,lower toxic GPCR drugs.The techniques make the rational design and implementation for GPCR drug screening particularly important.In this paper,we reviewed the progress of techniques and strategies for high-throughput screening of drugs targeting GPCRs,mainly including the strategies on receptor-ligand binding,second messenger detection,β-arrestin,reporter gene,internalization,oligomerizations and allosteric modulators.We also summarized some of the representative commercial techniques for reference.",
        "keywords": [
            "G protein-coupled receptors",
            "drug discovery",
            "high-throughput drug screening"
        ],
        "authors": [
            {
                "name": "YANG Xiu-ying",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2012
    },
    "IhovhPRY": {
        "id": "IhovhPRY",
        "title": "Oxidized low density lipoprotein receptor-1 mediates oxidized low density lipoprotein-induced apoptosis in human umbilical vein endothelial cells: role of reactive oxygen species.",
        "abstract": "Studies have shown that oxidized low density lipoprotein (ox-LDL) elicits both necrotic and apoptotic cell death and several mechanisms have been proposed. Ox-LDL induces reactive oxygen species (ROS), a second messenger that might be involved in apoptosis, formation in different types of cells including endothelial cells (ECs) and smooth muscle cells (SMCs). As lectin-like ox-LDL receptor-1 (LOX-1) was the main receptor for ox-LDL, this study was designed to determine whether the apoptosis induced by ox-LDL was mediated by LOX-1 in cultured human umbilical vein endothelial cells (HUVECs) and whether there is an association between LOX-1 mediated apoptosis and the production of ROS. After exposure to ox-LDL (50,100, and 150 microg/ml for 18 h), HUVECs exhibit typical apoptotic characteristics as determined by transmission electron microscopy and flow cytometry analysis in a dose-dependent pattern. Ox-LDL increases intracellular ROS formation including superoxide anion (O2-) and hydrogen peroxide (H2O2) in a dose-dependent and time-dependent manner. Pretreatment with anti-LOX-1 mAb, Vitamin C, apocynin or catalase significantly reduced ROS production and prevented ox-LDL-induced apoptosis, while indomethacin or allopurinol had no effect. These results suggest that LOX-1 mediates ox-LDL-induced apoptosis in endothelial cells and that ROS production and NADPH oxidase might play an important role in ox-LDL-induced apoptosis.",
        "keywords": [
            "oxidized low density lipoprotein",
            "apoptosis",
            "lectin-like ox-ldl receptor-1",
            "human umbilical vein endothelial cells",
            "reactive oxygen species",
            "cell death",
            "transmission electron microscopy",
            "second messengers",
            "hydrogen peroxide",
            "flow cytometry",
            "endothelial cell"
        ],
        "authors": [
            {
                "name": "Xiu-ping Chen",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China"
            },
            {
                "name": "Ke-li Xun",
                "org": "People's hospital of Binzhou, Binzhou, 256610, P.R. China"
            },
            {
                "name": "Qin Wu",
                "org": "Department of Pharmacology, Zunyi Medical College, Zunyi, 563000, P.R. China"
            },
            {
                "name": "Tian-tai Zhang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China"
            },
            {
                "name": "Jing-shan Shi",
                "org": "Department of Pharmacology, Zunyi Medical College, Zunyi, 563000, P.R. China"
            },
            {
                "name": "Guan-hua Du",
                "org": ""
            }
        ],
        "venue": "Vascular pharmacology",
        "year": 2007
    },
    "YdJPDxUK": {
        "id": "YdJPDxUK",
        "title": "Salvianolic Acid a prevents the pathological progression of hepatic fibrosis in high-fat diet-fed and streptozotocin-induced diabetic rats.",
        "abstract": "Type 2 diabetes patients have an increased risk of developing hepatic fibrosis. Salvianolic acid A (SalA) has been reported to be a strong polyphenolic anti-oxidant and free radical scavenger. The aim of the present study was to evaluate the effect of SalA on the pathological progression of hepatic fibrosis in high-fat diet (HFD)-fed and streptozotocin (STZ)-induced diabetic rats and to clarify the underlying mechanisms. Type 2 diabetic animal model with hepatic fibrosis was developed by a high-sucrose, HFD and low-dose STZ injection (i: p:). Diabetic rats were randomly divided into SalA group (0.3 mg/kg/day) and diabetic control groups fed with a HFD. After administration for four months, SalA reversed the hyperlipidemia and reduced hepatic triglyceride (TG). Hematoxylin-Eosin (HE) and Picro acid-Sirius red staining results indicated that SalA significantly alleviated the lesions of hepatic steatosis and fibrosis, with the reduction of type I and III collagens. The expression of alpha-smooth-muscle-actin (alpha-SMA) and transforming growth factor beta 1 (TGF-beta 1) in the liver were markedly down-regulated by SalA treatment. TUNEL staining showed that SalA reduced apoptosis in hepatocytes. In addition, SalA improved hepatic mitochondrial respiratory function in diabetic rats. Taken together, these findings demonstrated that SalA could prevent the pathological progression of hepatic fibrosis in HFD-fed and STZ-induced diabetic rats. The underlying mechanisms may be involved in reducing oxidative stress, suppressing alpha-SMA and TGF-beta 1 expression, as well as exerting anti-apoptotic and mitochondria-protective effects.",
        "keywords": [
            "Salvianolic Acid A",
            "Type 2 Diabetes",
            "Hepatic Fibrosis",
            "alpha-SMA",
            "TGF-beta 1",
            "Apoptosis"
        ],
        "authors": [
            {
                "name": "Guifen Qiang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Qi Xuan",
                "org": "Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China"
            },
            {
                "name": "Lili Shi",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Hengai Zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Bainian Chen",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xiaoxiu Li",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Mian Zu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Dan Zhou",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Jing Guo",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Haiguang Yang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "AMERICAN JOURNAL OF CHINESE MEDICINE",
        "year": 2014
    },
    "Ldk0dFfy": {
        "id": "Ldk0dFfy",
        "title": "An Investigation of the Antidepressant Action of Xiaoyaosan in Rats Using Ultra performance Liquid Chromatography-Mass Spectrometry Combined with Metabonomics: ANTIDEPRESSION STUDY OF XIAOYAOSAN BY UPLC-MS COMBINED WITH METABONOMICS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xuemei qin",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xiaojie tan",
                "org": ""
            },
            {
                "name": "jie xing",
                "org": ""
            },
            {
                "name": "junsheng tian",
                "org": ""
            },
            {
                "name": "yuzhi zhou",
                "org": ""
            },
            {
                "name": "younghae choi",
                "org": ""
            },
            {
                "name": "zhenyu li",
                "org": ""
            },
            {
                "name": "xingyu zheng",
                "org": ""
            },
            {
                "name": "jie cui",
                "org": ""
            },
            {
                "name": "xiaoxia gao",
                "org": ""
            }
        ],
        "venue": "Phytotherapy Research",
        "year": 2012
    },
    "boyYCRAK": {
        "id": "boyYCRAK",
        "title": "Certification of a new certified reference material of honokiol",
        "abstract": "Honokiol is the most important active pharmaceutical ingredient in Magnolia officinalis, which is a famous traditional Chinese medicine and commonly used in clinical practice. In order to control the quality of honokiol and related pharmaceuticals, a new certified reference material (CRM) of honokiol was developed. The studies of sample preparation, homogeneity, stability, value assignment, and uncertainty evaluation were accomplished in this paper. Three different methods, including differential scanning calorimetry (DSC), mass balance method (MB), and coulometric titration (CT), were employed to determine the purity of honokiol. Specifically, the DSC and CT methods for purity determination of honokiol were established for the first time. The purity of honokiol CRM, after validation and evaluation, was found to be 99.3 %, with an expanded uncertainty of 0.5 % (k = 2).",
        "keywords": [
            "Honokiol",
            " CRM",
            " DSC",
            " Coulometric titration",
            " Mass balance"
        ],
        "authors": [
            {
                "name": "shiying yang",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            },
            {
                "name": "dezhi yang",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            },
            {
                "name": "kun hu",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            },
            {
                "name": "haohui zhou",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            },
            {
                "name": "yonghui guo",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            },
            {
                "name": "guanhua du",
                "org": "Beijing Key Laboratory of Drug Targets and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            },
            {
                "name": "yang lu",
                "org": "Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China"
            }
        ],
        "venue": "Analytical and Bioanalytical Chemistry",
        "year": 2015
    },
    "bPCRsiqH": {
        "id": "bPCRsiqH",
        "title": "In vitro anti-influenza viral activities of constituents from Caesalpinia sappan.",
        "abstract": "Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.",
        "keywords": [
            "leguminosae",
            "neuraminidase",
            "influenza virus",
            "sappanchalcone",
            "caesalpinia sappan",
            "in vitro",
            "chemical composition"
        ],
        "authors": [
            {
                "name": "Ai-Lin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shi-Hui Shu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Simon Ming Yuen Lee",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Yi-Tao Wang",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Planta medica",
        "year": 2009
    },
    "oqN0tXZu": {
        "id": "oqN0tXZu",
        "title": "Purity determination and uncertainty evaluation of a new certified reference material of Pinocembrin",
        "abstract": "This study introduces a purity determination and uncertainty evaluation method for a new certified reference material (CRM) of Pinocembrin (GBW09554), using a mass balance method and differential scanning calorimetry (DSC). Sample preparation, homogeneity and stability studies, value characterization, and evaluation of uncertainty of a new CRM of Pinocembrin are presented in this paper. The homogeneity and stability are checked using a mass balance method and the stability is tested under different storage conditions. The CRM described above was found to be homogeneous and stable at 25 degrees C for at least one year. The certified value of Pinocembrin CRM is 99.7% with an extended uncertainty of 0.5% (k = 2). A DSC method is used for purity determination of Pinocembrin for the first time in this paper. The new CRM of Pinocembrin can be used to validate analytical methods, improve the accuracy and comparability of measurement data, establish meteorological traceability of analytical results as well as control the quality of Pinocembrin in relevant food and pharmaceutical formulations.",
        "keywords": [],
        "authors": [
            {
                "name": "li zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Polymorph Drugs, Beijing 100050, Peoples R China"
            },
            {
                "name": "yonghui guo",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Polymorph Drugs, Beijing 100050, Peoples R China"
            },
            {
                "name": "zhengzheng zhou",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Polymorph Drugs, Beijing 100050, Peoples R China"
            },
            {
                "name": "guanhua du",
                "org": "Peking Union Med Coll, Beijing 100050, Peoples R China"
            },
            {
                "name": "yang lu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Polymorph Drugs, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "ANALYTICAL METHODS",
        "year": 2014
    },
    "WIcwOrBh": {
        "id": "WIcwOrBh",
        "title": "Preventive and Therapeutic Effects of Danshen on Digestive System Diseases",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yanqiao zang",
                "org": "peking union medical college"
            },
            {
                "name": "ying dai",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "mei gao",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "0smnRYLC": {
        "id": "0smnRYLC",
        "title": "Study on glutathione S-transferase inhibitory derived from an actinomycete",
        "abstract": "Glutathione S-transferase-π(GST-π) level usually increased apparently in sufferring from certain kinds of cancers,and it played an important role in the process of drug resistant tumor cells against anti-tumor agents.Inhibition of the overexpressed enzyme activity will contribute to overcome the resistance.Therefore,GST-π has been considered as a potential drug target for the cancer treatment.By using the GST-π high throughput screening system model which was developed in our laboratory,an actinomycete strain No.550 has shown inhibitory activity to GST-π.A compound named No.550-A was isolated from the mycelium,and by solvent extraction by Sephadex LH-20 column chromatography,and HPLC purification,the compound showed moderate activity against GST-π with the IC50 of 21.4μg/ml,by physico-chemical spectral analysis,the structure of the compound was identical with genistein,of which having inhibitory activity against GST-π was firstly reported.",
        "keywords": [
            "Genistein",
            "Enzyme inhibitor",
            "GST"
        ],
        "authors": [
            {
                "name": "Li Shao-jing",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing "
            },
            {
                "name": "Du Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing "
            }
        ],
        "venue": "Chinese Journal of Antibiotics",
        "year": 2007
    },
    "lTM2NNhm": {
        "id": "lTM2NNhm",
        "title": "Lipopolysaccharide-induced serotonin transporter up-regulation involves PKG-I and p38MAPK activation partially through A3 adenosine receptor.",
        "abstract": "Serotonin transporter (SERT) is a critical determinant of synaptic serotonin (5-hydroxytryptamine, 5-HT) inactivation which plays a critical role in the pathology of depression and other mood disorders. Lipopolysaccharide (LPS), a potent activator of the inflammatory system, has been reported to cause depression symptoms by the modulation of SERT in vivo and in vitro. This study is aimed to investigate the underlying mechanism of LPS-induced SERT modulation. The 4-(4-(dimethylamino) styryl)-N-methylpyridinium iodide (ASP) assay was used to detect dynamic 5-HT uptake as read out of SERT activities in RBL-2H3 cells, and cytosol Ca2+ concentrations ([Ca2+]i) and nitric oxide (NO) were examined. Using specific cyclic GMP-dependent protein kinase type I (PKG-I), p38 mitogen-activated protein kinases (p38MAPK) and A3 adenosine receptor (A3AR) inhibitors, SERT expression was evaluated by western blot and immunofluorescence analysis. Results showed that 24 h treatment with LPS stimulated 5-HT transport and up-regulate plasma membrane distribution of SERT in RBL-2H3 cells. LPS treatment increased NO and [Ca2+]i, and led to significant increases in levels of phosphorylated calcium/calmodulin-dependent protein kinase type II (CaMK-II), inducible NOS (iNOS) and PKG-I as well as active p38 MAPK. Moreover, PKG-I inhibitor KT5823 or p38MAPK inhibitor SB203580 respectively impaired SERT activation and transposition to plasma membrane by LPS. Notably, A3 adenosine receptor inhibitor MRS1191 also hindered SERT stimulation by LPS. In conclusion, LPS-induced 5-HT uptake and transposition to plasma membrane of SERT in RBL-2H3 cells involves CaMK-II/ iNOS/PKG-I and p38 MAPK activation, which may be partially mediated by A3 adenosine receptor activation. This finding provides a novel insight into the interrelationship between LPS and depression.",
        "keywords": [
            "Serotonin transport (SERT)",
            "lipopolysaccharide",
            "cyclic GMP-dependent protein kinase type I (PKG-I)",
            "p38 mitogen-activated protein kinases (p38MAPK)",
            "A3 adenosine receptor"
        ],
        "authors": [
            {
                "name": "Rui Zhao",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Shoubao Wang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Zhonglin Huang",
                "org": "Xinxiang Med Univ, Sch Pharm, Xinxiang, Henan, Peoples R China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Xiaoyu Bai",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Dan Zhou",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Zhizhen Qin",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target & Screening Res, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "BIOSCIENCE TRENDS",
        "year": 2016
    },
    "hv5w9qlp": {
        "id": "hv5w9qlp",
        "title": "Synthesis and activity of hydroxyethylene peptidomimetic inhibitors of humanβ-secretase",
        "abstract": "A series ofβ-secretase peptidomimetic inhibitors with Leu*Ala hydroxyethylene dipeptide isostere were synthesized and theirβ-secretase inhibitory activities were measured.The most potent compound N9 showed an inhibitory rate of 59.66%(10 mg/mL).Compound N9 might be further modified by means of computational chemical methodology.",
        "keywords": [
            "Bioactivity",
            "Hydroxyethylene isostere",
            "β-Secretase inhibitors",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Chao Ma",
                "org": ""
            },
            {
                "name": "Yue-Hua Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Xiao-Ming Yang",
                "org": ""
            },
            {
                "name": "Xiao-Min Zou",
                "org": ""
            },
            {
                "name": "Yang L",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "Ping Xu",
                "org": " 1.Department of Medicinal Chemistry,School of Pharmaceutical Sciences,Peking University,Beijing ,China"
            }
        ],
        "venue": "中国药学(英文版)",
        "year": 2008
    },
    "RkvKdXLY": {
        "id": "RkvKdXLY",
        "title": "Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?",
        "abstract": "Endothelial activation and dysfunction induced by oxidized modified low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have shown that a new lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) mediates the recognition and internalization of ox-LDL. LOX-1 is the main receptor for ox-LDL and may play an important role in the pathogenesis of hypertension, diabetes, and, especially, of atherosclerosis. The potential role of LOX-1 in the pathogenesis of atherosclerosis includes: endocytosis of ox-LDL, expression co-location with atherosclerosis enhanced by atherosclerosis-related risk factors, elevated LOX-1 protein in cardiovascular disease, effects related to atherosclerosis and eliminated by antiatherosclerotic drugs. Identification and regulation of LOX-1 and understanding its signal transduction pathways might improve our insight toward the pathogenesis of atherosclerosis and provide a selective treatment approach. LOX-1 might be a potential and promising target for the development of novel antiatherosclerotic drugs. However, due to limited knowledge about LOX-1, there are still many questions to be answered.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiu-Ping Chen",
                "org": ""
            },
            {
                "name": "Tian-Tai Zhang",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Cardiovascular drug reviews",
        "year": 2007
    },
    "GodQ4Xj7": {
        "id": "GodQ4Xj7",
        "title": "Polymorphs of 4-[2-dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenyl 4-methyl-benzoate hydrochloride, methods for preparing the same and use of the same",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "youxin li",
                "org": ""
            },
            {
                "name": "wanhui liu",
                "org": ""
            },
            {
                "name": "yang lv",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "qingguo meng",
                "org": ""
            },
            {
                "name": "mina yang",
                "org": ""
            },
            {
                "name": "fengmei zhou",
                "org": ""
            },
            {
                "name": "ju li",
                "org": ""
            },
            {
                "name": "xuemei zhang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "uDcenYMz": {
        "id": "uDcenYMz",
        "title": "Effects of the effective components group of Xiaoxuming decoction on MCAO rats",
        "abstract": "OBJECTIVE: To investigate the protective effects of the effective components group of Xiao-Xu-Ming decoction (XXM) on focal cerebral ischemia rats. METHODS: The model of focal cerebral ischemia was made by middle cerebral artery occlusion (MCAO) with nylon suture. The neuroethological score and the staying time on slope board were gotten after 48 h of the operation. The percentage of cerebral infarction volume to total brain volume was calculated by TTC staining. Furthermore, the content of MDA, the activities of SOD and GSH-Px, and the activity of NOS in the brain tissue were detected by photospectrometer analysis system. RESULTS: The effective components group of Xiao-Xu-Ming decoction could significantly reduce the scores of neurological deficits , alleviate the cerebral infarction volume, improve the activity of SOD, reduce the content of MDA, and decrease the activity of iN-OS, but have no effect on the activity of GSH-Px. CONCLUSION: The effective components group of Xiao-Xu-Ming decoction may attenuate the focal cerebral ischemia injury in rats, and the mechanism is related to regulate the balance between oxidation and anti-oxidation and decrease the activity of iNOS in the brain tissue. Copyright 2012 by the Chinese Pharmaceutical Association.",
        "keywords": [
            "Effective components group",
            "Middle cerebral artery occlusion(MCAO)",
            "Xiao-Xu-Ming decoction (XXM)"
        ],
        "authors": [
            {
                "name": "WANG Yue-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "HE Xiao-li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "YANG Hai-guang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "QIN Hai-lin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2012
    },
    "enWUR866": {
        "id": "enWUR866",
        "title": "Advances in research on uncoupling proteins and nervous system disease",
        "abstract": "Uncoupling proteins (UCPs) are a family of mitochondrial anion-carrier proteins located in the inner mitochondrial membrane. UCP1 is expressed primarily in brown fat cells, which is classically associated with non-shivering thermogenesis. Recent evidence indicates that UCP family proteins are also present in selected neurons, such as UCP2, UCP4, UCP5/BM-CP1. Unlike UCP1, these proteins are not crucial for heat production, but they can be activated by free radicals and free fatty acids, and their activities have a profound influence on neuron function. Neuronal UCPs can directly influence neurotransmission by regulating mitochondrial biogenesis, calcium flux and free radical production. The study of regulation and function of these proteins will offer a better understanding of nervous system disease.",
        "keywords": [
            "CNS",
            "Mitochondria",
            "Nervous system disease",
            "Uncoupling proteins"
        ],
        "authors": [
            {
                "name": "HE Xiao-li",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "ZHANG Dan-shen",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2008
    },
    "vB2S8aGJ": {
        "id": "vB2S8aGJ",
        "title": "The Study of Drug Quantity and the Control of Drugs Effects",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "DU Guan-hua",
                "org": "Institute of Material Medica,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "LV Yang",
                "org": "Institute of Material Medica,Chinese Academy of Medical Science,Beijing ,China"
            }
        ],
        "venue": "Food and Drug",
        "year": 2008
    },
    "IA8l9i95": {
        "id": "IA8l9i95",
        "title": "Development of high throughput screening method for Rho kinase inhibitors",
        "abstract": "OBJECTIVE: To screen new Rho kinase (Rho-associated coiled-coil forming protein kinase, ROCK) inhibitors for the preventation and treatment of the cardiovascular diseases and nervous system diseases and to establish a luminescent based high throughput screening (HTS) model. METHODS: The cDNA encoding the amino acids 3 - 543 of human ROCK-I was amplified and subcloned into pET32a expression vector to express the protein in Escherichia coli (E. coli) BL21 (DE3) as soluble protein. The kinase activity of the purified ROCK-I was determined with Kinase-Glo Luminescent Kinase Assay kit. Z′ was used to evaluate the assay quality of HTS. RESULTS: Recombinant human ROCK-I showed well kinase activity. The parameter Z′ was 0.75, which showed a high feasibility and stability of the assay. Total compounds about 30 000 were screened, and 4 compounds and 5 extracts showed the inhibition for Rho kinase activity. CONCLUSION: An easy and rapid procedure was established to harvest a large quantity of active recombinant human ROCK-I from E. coli. The luminescent assay is stable, sensitive, reproducible and well suited for HTS of Rho kinase inhibitors.",
        "keywords": [
            "Escherichia coli",
            "Expression",
            "High throughput screening",
            "Luminescent assay",
            "Rho kinase"
        ],
        "authors": [
            {
                "name": "GONG Li-li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "FANG Lian-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "PENG Jian-hao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "HE Guo-rong",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2010
    },
    "YuMKopjm": {
        "id": "YuMKopjm",
        "title": "Evaluation and Analysis on the Utilization of Quinolones for the Inpatients of Beijing Hospital of Ministry of Health During 2003～2008",
        "abstract": "OBJECTIVE: To explore the method for evaluating the rational utilization of antibiotics in hospital,and to discuss the feasibility of rational use of quinolones using bacterial drug resistance as index so as to optimize the use of antibiotics in hospital. METHODS: The utilization of quinolones in our hospital from 2003 to 2008 were statistically analyzed and evaluated based on the data of bacterial drug resistance in our hospital. RESULTS: Generally,the utility of quinolones in our hospital was relative stable,with a conformity noted between the medication frequency of quinolones and the bacterial drug resistance level. However,the consumption amount of quinolones was also associated with the degree of the importance attached to the related guidelines both at home and abroad,for example,influenced by the IDSA/ATS Guidelines on the Management of Community - Acquired Pneumonia in Adults,the consumption of moxifloxacin has been increasing recently while the consumption of levofloxacin has been declining. CONCLUSION: Great importance should be attached to clinical rational use of quinolones as well as the bacterial drug resistance test of cases in general wards so as to increase the bacterial drug resistance test rate and gain the epidemiological data of pathogenic microorganisms in general wards because it is conducive to rational use of anti - infective drugs.",
        "keywords": [
            "Levofloxacin",
            "Quinolones",
            "Evaluation and analysis",
            "Bacterial drug resistance"
        ],
        "authors": [
            {
                "name": "LIU Zhi-jun",
                "org": " Dept. of Pharmacy, Beijing Hospital of Ministry of Health,Beijing ,China"
            },
            {
                "name": "CHEN Dong-ke",
                "org": " Dept. of Pharmacy, Beijing Hospital of Ministry of Health,Beijing ,China"
            },
            {
                "name": "FU De-xing",
                "org": " Dept. of Pharmacy, Beijing Hospital of Ministry of Health,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "HU Xin",
                "org": " Dept. of Pharmacy, Beijing Hospital of Ministry of Health,Beijing ,China"
            }
        ],
        "venue": "Evaluation and Analysis of Drug-Use in Hospitals of China",
        "year": 2010
    },
    "iS6cP5qk": {
        "id": "iS6cP5qk",
        "title": "Therapeutic effect of edaravone in transient global brain ischemia/reperfusion rats",
        "abstract": "OBJECTIVE: To evaluate the therapeutic effect of edaravone in transient global brain ischemia/reperfusion rats. METHODS: Adult male Sprague-Dawley rats were subjected to global cerebral ischemia for 20 min by four-vessel occlusion. Edaravone (3 mg·kg -1) was administrated intravenously 30 min after reperfusion. Histological examination by Nissl staining was employed to assess the neuronal injury after ischemia. The activities of superoxide dismutase(SOD), myeloperoxidase(MPO) and the content of malondialdehyde (MDA) in brain tissue were tested by colorimetric assays. Respiratory activity of brain mitochondria was determined. RESULTS: Edaravone significantly ameliorated neurological deficits and alleviated the degree of hippocampal neuronal loss at 72 h after global cerebral I/R. Treatment with edaravone reduced the compensatory increase of SOD and MPO activity, and decreased the MDA level and NO activity. Edaravone also improved the respiratory activity of 4VO brain mitochondria, through increasing ADP/O, V3, RCI, OPR. CONCLUSION: Edaravone exert a therapeutic effect against global cerebral ischemic injury in rats by inhibiting oxidative stress and improving respiratory activity of mitochondria.",
        "keywords": [
            "4-vessle occlusion",
            "Edaravone",
            "Global brain ischemia",
            "Mitochondria"
        ],
        "authors": [
            {
                "name": "Mei Gao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li I. Shi",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "ZHANG Heng-ai",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "CHEN Bai-nian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "WANG Qiao-yun",
                "org": "Binzhou Medical University of Shandong(Binzhou Medical University of Shandong),,China"
            },
            {
                "name": "XUAN Zhao-hong",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2011
    },
    "3jRVZVCD": {
        "id": "3jRVZVCD",
        "title": "Establishment of GPCR expression cell lines using SNAP-tag technology: A case example of urotensin II receptor",
        "abstract": "Objective: G-protein coupled receptors (GPCRs) represent crucial cell surface receptors in the drug discovery process. Here we present a post-translationally labeling strategy that uses SNAP-tag® technology to identify stably transfected GPCRs clones exemplified by the human urotensin II (UII) receptor (UT). Materials and methods: In this study, we transfected SNAP-UT into HEK293A cells to generate stable cell clones. Results: In total, 77.5%, 8.6%, 4.7%, and 2.2% of clones had fluorescence intensities that were 2-, 4-, 8-, and 16-fold higher than the control, respectively. In the recombinant clones, the fluorescence intensities were parallel well with the RNA levels of UT. For example, the fluorescence intensity of clone A8 was four times higher than clone A50, and qRT-PCR results showed that the UT mRNA levels in A8 were 3.7 times higher than A50. The binding assay result also suggested that the structure of the recombinant receptor was consistent with wild-type UT. Furthermore, the downstream signals conducted by the recombinant UT were matching with the wild-type. In recombinant clones, both Inositol-1-phosphate (IP1) accumulations and calcium flux levels rose dose-dependently under UII stimulation, and significantly prominent in clone A8 than A50. Conclusion: Our results indicate that SNAP-tag approach on GPCR cell line establishment is fast and simple, furthermore, can quantitatively provide recombinant gene expression levels.",
        "keywords": [
            "Cell line",
            "G-protein coupled receptor",
            "SNAP-tag technology",
            "Urotensin II",
            "Urotensin II receptor"
        ],
        "authors": [
            {
                "name": "Xiuying Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiaoming Zhu",
                "org": "Prince of Wales Hospital Hong Kong(Prince of Wales Hospital),Hong Kong,China"
            },
            {
                "name": "Bainian Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guifen Qiang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lianhua Fang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Life Science Journal",
        "year": 2013
    },
    "tcl5VdZw": {
        "id": "tcl5VdZw",
        "title": "Microtubule-stabilizing agents: New drug discovery and cancer therapy.",
        "abstract": "Microtubule-stabilizing agents (MSAs) have been highly successful in the treatment of cancer in the past 20years. To date, three classes of MSAs have entered the clinical trial stage or been approved for clinical anticancer chemotherapy, and more than 10 classes of novel structural MSAs have been derived from natural resources. The microtubule typically contains two MSA-binding sites: the taxoid site and the laulimalide/peloruside site. All defined MSAs are known to bind at either of these sites, with subtle but significant differences. MSAs with different binding sites may produce a synergistic effect. Although having been extensively applied in the clinical setting, paclitaxel and other approved MSAs still pose many challenges such as multidrug resistance, low bioavailability, poor solubility, high toxicity, and low passage through the blood-brain barrier. A variety of studies focus on the structure-activity relationship in order to improve the pharmaceutical properties of these agents. Here, the mechanisms of action, advancements in pharmacological research, and clinical developments of defined MSAs during the past decade are discussed. The latest discovered MSAs are also briefly introduced in this review. The increasing number of natural MSAs indicates the potential discovery of more novel, natural MSAs with different structural bases, which will further promote the development of anticancer chemotherapy.",
        "keywords": [
            "cancer therapy",
            "epothilone",
            "microtubule-stabilizing agent",
            "natural product",
            "paclitaxel"
        ],
        "authors": [
            {
                "name": "Ying Zhao",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China; Chinese Pharmacological Society, Beijing 100050, PR China."
            },
            {
                "name": "Xin Mu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China; Chinese Pharmacological Society, Beijing 100050, PR China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China; Chinese Pharmacological Society, Beijing 100050, PR China."
            }
        ],
        "venue": "Pharmacology & therapeutics",
        "year": 2015
    },
    "hU28y9i4": {
        "id": "hU28y9i4",
        "title": "PROTECTIVE EFFECTS OF DRACOCEPHALU MTANGUTICUM MAXIM ON ACUTE MYOCARDIAL ISCHEMIA IN CORONARY ARTERY LIGATED RATS",
        "abstract": "Objective To observe the protective effects of water-solubility fraction extracted from Dracocephalumtanguticum Maxim(DtM)(traditional Tibetan medicine) on rats with acute myocardial ischemia.Methods The acute myocardial ischemia model was induced by ligation of left anterior descending coronary artery at the distal one third segment in opened chest rats.The Ⅱ-lead electrocardiogram were examined before and after ligation,the infarct area was showed with TTC stain after ligation.Furthermore,the effect of DtM on the above parameters and CK and LDH contents of serum were also studied in comparison with model.Results Compared with model,all groups using different dosage DtM could reduce the area of myocardial infarction(P<0.05).Furthermore,The group using 2.5g gruff per kilogram weight dosage of DtM markedly lowered the elevation of S-T segment and the amplitude of T wave in the electrocardiograms of rats,and reduced the LDH contents of serum,no effect was shown in others on the above parameters in comparison with model.Conclusion DtM produced the effect against acute myocardial ischemia in rats.",
        "keywords": [
            "Dracocephalumtanguticum Maxim Acute myocardial ischemia Coronary artery ligation Protective effect"
        ],
        "authors": [
            {
                "name": "Liu Fengyun",
                "org": " Centralab,Qinghai Cardio-vascular Diseases Vocational Hospital"
            },
            {
                "name": "Wang Shoubao",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences"
            },
            {
                "name": "Hai Ping",
                "org": " Centralab,Qinghai Cardio-vascular Diseases Vocational Hospital"
            },
            {
                "name": "Wang Hongqing",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences"
            },
            {
                "name": "Chen Ruoyun",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences"
            },
            {
                "name": "Du Guanhua",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences"
            }
        ],
        "venue": "Journal of Qinghai Medical College",
        "year": 2011
    },
    "OFlDKjqP": {
        "id": "OFlDKjqP",
        "title": "Value and Uncertainty Evaluation Study of Certified Reference Material of Chemical Purity of Bergenin",
        "abstract": "OBJECTIVE: To establish metrological models to obtain the certified value and uncertainty evaluation calculation model of chemical purity of bergenin, and to provide condition for reference material tracing to the source. METHODS: Reference material of chemical purity of bergenin was used as subject investigated. HPLC method and DSC both were adopted. HPLC method: Agilent Eclipse XDB C18(150 mm×4.6 mm,5 μm) column with mobile phase consisted of methanol-water (21 ∶ 79) at a flow rate of 1.0 mL·min-1. The UV detection wavelength was set at 275 nm, and the column temperature was 30 ℃. The DSC method: heating rate at 9.0 K·min-1, the sample weight was 2.3～3.7 mg, static air as furnace gas. RESULTS: The certified value and the expanded uncertainty of reference material of chemical purity of bergenin was 99.74%±0.22%. CONCLUSION: Certified value of reference material of bergenin obtained in this article has been proved to be a primary CRM with great accuracy and traceability. This result helped provide the foundation of CRM being in line with international standard, the modernization and standardization in the national pharmaceutical industry.",
        "keywords": [
            "HPLC",
            "Certified value and uncertainty evaluation",
            "Primary reference material",
            "Bergenin",
            "DSC"
        ],
        "authors": [
            {
                "name": "ZHOU Hao-hui",
                "org": "Peking Union Medical College, Institute of Materia Medica & Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "ZHOU Zheng-zheng",
                "org": "Peking Union Medical College, Institute of Materia Medica & Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "GUO Yong-hui",
                "org": "Peking Union Medical College, Institute of Materia Medica & Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "YANG Shi-ying",
                "org": "Peking Union Medical College, Institute of Materia Medica & Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Peking Union Medical College, Institute of Materia Medica & Chinese Academy of Medical Sciences, Beijing , China"
            },
            {
                "name": "Lü Yang",
                "org": "Peking Union Medical College, Institute of Materia Medica & Chinese Academy of Medical Sciences, Beijing , China"
            }
        ],
        "venue": "China Pharmacy",
        "year": 2012
    },
    "M1qZDmma": {
        "id": "M1qZDmma",
        "title": "Optimizing synthetic method of pinocembrin by uniform experiment design",
        "abstract": "5,7-Dihydroxyflavanone was synthesized by hydrogenation of 5,7-dihydroxyflavone with hydrogen,catalyzed by Pd-C.The reaction conditions were optimized using the method of uniform experiment design to get 84%yield.",
        "keywords": [
            "uniform design",
            "7-dihydroxyflavone",
            "5",
            "Pd-C",
            "7-dihydroxyflavanone"
        ],
        "authors": [
            {
                "name": "CHENG Yong-Hao",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            },
            {
                "name": "DUAN Ya-Bo",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            },
            {
                "name": "QI Yan",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            },
            {
                "name": "TONG Yuan-Feng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            },
            {
                "name": "GUO Xiao-Yun",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            },
            {
                "name": "WU Song",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College.Beijing ,China"
            }
        ],
        "venue": "Chemical Research and Application",
        "year": 2006
    },
    "3crG5Yl9": {
        "id": "3crG5Yl9",
        "title": "Pharmacokinetic study of salvianolic acid A in beagle dog after oral administration by a liquid chromatography-mass spectrometry method: a study on bioavailability and dose proportionality.",
        "abstract": "Salvianolic acid A (SAA) is one of the main water-soluble components isolated from Salvia miltiorrhiza Bunge. Pharmacological researches revealed that it had various curative activities after oral and intravenous administration, including beneficial effects on diabetes and its complications, cardioprotective effect, anti-platelet aggregation, and so on. However, there is no report regarding the pharmacokinetics of SAA in beagle dogs after oral administration up to now.To study the pharmacokinetics of different doses of SAA in beagle dogs and figure out the absolute bioavailability and dose proportionality of SAA after oral administration.Male and female beagle dogs were orally administered SAA 5, 10 and 20mg/kg randomly. The plasma drug concentration was detected by a rapid, sensitive and reproducible liquid chromatography-mass spectrometry (LC-MS) method. The pharmacokinetic parameters were calculated from plasma concentration-time data using the DAS pharmacokinetic software Data Analysis System Version 3.0 program.After single-dose oral administration of SAA, the mean peak plasma concentration (Cmax) values for groups treated with 5, 10 and 20 mg/kg doses ranged from 14.38 to 38.18 µg/L, and the mean area under the concentration-time curve (AUC(0-t)) values ranged from 38.77 to 130.33 (µg/L·h). SAA showed lack of dose proportionality over the dose range 5-20mg/kg, based on the power model. However, the increase in systemic exposure with dose appeared linear. The absolute bioavailability was calculated to range from 1.47% to 1.84%.The pharmacokinetic properties of SAA in beagle dogs after oral administration were characterized as rapid oral absorption, quick clearance, and poor absolute bioavailability. Systemic exposure exhibited lack of dose proportionality over the dose range 5-20mg/kg. Furthermore, a readily preparative LC-MS method was demonstrated in this study for the research of traditional Chinese medicine.",
        "keywords": [],
        "authors": [
            {
                "name": "Jialin Sun",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Junke Song",
                "org": ""
            },
            {
                "name": "Shuo Tian",
                "org": ""
            },
            {
                "name": "Chao Huang",
                "org": ""
            },
            {
                "name": "Zhangying Feng",
                "org": ""
            },
            {
                "name": "Yang Lv",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2013
    },
    "iXneZT33": {
        "id": "iXneZT33",
        "title": "Anti-influenza virus activities of flavonoids from the medicinal plant Elsholtzia rugulosa.",
        "abstract": "ELSHOLTZIA RUGULOSA (Lamiaceae), a common Chinese herb, is widely used in the treatment of cold and fever. In order to elucidate the action mechanism and the active principles from the plant against anti-influenza virus, the influenza virus neuraminidase (NA) activity assay and IN VITRO antiviral activity assay were established, and the isolation of the active principles was guided by NA activity. Finally, 5 active constituents were obtained, namely apigenin ( 1), luteolin ( 2), apiin ( 3), galuteolin ( 4) and luteolin 3'-glucuronyl acid methyl ester ( 5), respectively. They all belong to the flavonoids. The IN VITRO antiviral assay using a cytopathic effect (CPE) reduction method showed that they all possessed anti-influenza virus activity. Among them, apigenin and luteolin exhibited the highest activities against influenza virus (H3N2) with IC (50) values of 1.43 microg/mL and 2.06 microg/mL, respectively. The structure-activity relationship (SAR) of these flavonoids with different chemical structures and their anti-influenza virus activities was addressed in this study.",
        "keywords": [
            "flavonoids",
            "elsholtzia rugulosa",
            "influenza virus",
            "neuraminidase (na)",
            "lamiaceae"
        ],
        "authors": [
            {
                "name": "Ai-Lin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Bo Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Simon Mingyuen Lee",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Yi-Tao Wang",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Planta medica",
        "year": 2008
    },
    "Y5SqjndL": {
        "id": "Y5SqjndL",
        "title": "Expression, purification and antibody preparation of recombinat SARS-CoV X5 protein]",
        "abstract": "X5 protein is one of the putative unknown proteins of SARS-CoV. The recombinant protein has been successfully expressed in E. coli in the form of insoluble inclusion body. The inclusion body was dissolved in high concentration of urea. Affinity Chromatography was preformed to purify the denatured protein, and then the product was refolded in a series of gradient solutions of urea. The purified protein was obtained with the purity of > 95% and the yield of 93.3 mg x L(-1). Polyclonal antibody of this protein was obtained, and Western blotting assay indicated that the X5 protein has the strong property of antigen. Sixty-eight percent of the recombinant protein sequence was confirmed by LC-ESI-MS/MS analysis.",
        "keywords": [
            "renaturation",
            "dialysis",
            "sars-cov",
            "x5",
            "inclusion body",
            "predicted unknown proteins"
        ],
        "authors": [
            {
                "name": "Li-Na Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC and Key Laboratory of Bioactive Substances and Resources Utilization,Ministry of Education of PRC,Beijing ,China"
            },
            {
                "name": "Jian-Qiang Kong",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC and Key Laboratory of Bioactive Substances and Resources Utilization,Ministry of Education of PRC,Beijing ,China"
            },
            {
                "name": "Ping Zhu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC and Key Laboratory of Bioactive Substances and Resources Utilization,Ministry of Education of PRC,Beijing ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC and Key Laboratory of Bioactive Substances and Resources Utilization,Ministry of Education of PRC,Beijing ,China"
            },
            {
                "name": "Wei Wang",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC and Key Laboratory of Bioactive Substances and Resources Utilization,Ministry of Education of PRC,Beijing ,China"
            },
            {
                "name": "Ke-Di Cheng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC and Key Laboratory of Bioactive Substances and Resources Utilization,Ministry of Education of PRC,Beijing ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2008
    },
    "PSwFi35Y": {
        "id": "PSwFi35Y",
        "title": "Predictions of BuChE Inhibitors Using Support Vector Machine and Naive Bayesian Classification Techniques in Drug Discovery",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "ailin liu",
                "org": ""
            },
            {
                "name": "shengqian yang",
                "org": ""
            },
            {
                "name": "dan zhou",
                "org": ""
            },
            {
                "name": "li gao",
                "org": ""
            },
            {
                "name": "ranyao yang",
                "org": ""
            },
            {
                "name": "jiansong fang",
                "org": ""
            }
        ],
        "venue": "Journal of Chemical Information and Modeling",
        "year": 2013
    },
    "9fy1aqtR": {
        "id": "9fy1aqtR",
        "title": "Active neuraminidase constituents of Polygonum cuspidatum against influenza A(H1N1) influenza virus]",
        "abstract": "To isolate and identify active neuraminidase constituents of Polygonum cuspidatum against influenza A (H1N1) influenza virus.On the basis of the bioassay-guided fractionation,such chromatographic methods as silica gel, sephadex LH-20 and HPLC were adopted to isolate active constituents of extracts from Polygonum cuspidatum, and their molecular structures were identifiied on the basis of their spectral data such as NMR and MS and physico-chemical properties.Seven compounds were isolated from the ethyl acetate extract of P. cuspidatum and identified as 2-methoxystypandrone (1), emodin (2), resveratrol (3), polydatin (4), emodin-8-O-beta-D-glucopyranoside (5), (E)-3, 5, 12-trihydroxystilbene-3-O-beta-D-glucopyranoside-2'-(3\", 4\", 5\"-trihydroxybenzoate) (6) and catechin-3-O-gallate (7), respectively. Among them, the NA test showed that compounds 3, 6 and 7 had inhibitory effect against NAs activity, with IC50 values of 129.8, 44.8 and 21.3 micromol x L(-1), respectively. Moreover, the further CPE test showed compounds 6 and 7 had significant inhibitory effect against H1N influenza virus (EC50 = 5.9, 0.9 micromol x L(-1), respectively), with very low cytotoxicity to the host cells, their therapeutic selective index(SI) in MDCK cells ranged from 56 to 269.The neuraminidase inhibitors against H1N1 anti-influenza virus isolated from extracts of P. cuspidatum on the basis of the bioassay-guided fractionation are significant in specifying their therapeutic material basis and drug R&D against influenza.",
        "keywords": [
            "neuraminidase",
            "h1n1 influenza a",
            "inhibitor",
            "polygonum cuspidatum"
        ],
        "authors": [
            {
                "name": "Kao-Tan Chen",
                "org": "Key Laboratory of Chinese Medicinal Resource from Lingnan,Ministry of Education,Research Center of Medicinal Plant Resource Science and Engineering,Guangzhou University of Chinese Medicine,Guangzhou ,China"
            },
            {
                "name": "Wei-Ling Zhou",
                "org": "Beijing Key Laboratory of Drug Target Research and Drug Screening,Institiute of Matetia Medica, Chinese Academy Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Jia-Wei Liu",
                "org": "Key Laboratory of Chinese Medicinal Resource from Lingnan,Ministry of Education,Research Center of Medicinal Plant Resource Science and Engineering,Guangzhou University of Chinese Medicine,Guangzhou ,China"
            },
            {
                "name": "Mian Zu",
                "org": "Beijing Key Laboratory of Drug Target Research and Drug Screening,Institiute of Matetia Medica, Chinese Academy Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Zi-Ning He",
                "org": "Key Laboratory of Chinese Medicinal Resource from Lingnan,Ministry of Education,Research Center of Medicinal Plant Resource Science and Engineering,Guangzhou University of Chinese Medicine,Guangzhou ,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Beijing Key Laboratory of Drug Target Research and Drug Screening,Institiute of Matetia Medica, Chinese Academy Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Wei-Wen Chen",
                "org": "Key Laboratory of Chinese Medicinal Resource from Lingnan,Ministry of Education,Research Center of Medicinal Plant Resource Science and Engineering,Guangzhou University of Chinese Medicine,Guangzhou ,China"
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Beijing Key Laboratory of Drug Target Research and Drug Screening,Institiute of Matetia Medica, Chinese Academy Science and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2012
    },
    "VAvBIs4h": {
        "id": "VAvBIs4h",
        "title": "Oncological miR-182-3p, a Novel Smooth Muscle Cell Phenotype Modulator, Evidences From Model Rats and Patients.",
        "abstract": "Vascular smooth muscle cell (VSMC) phenotype change is a hallmark of vascular remodeling, which contributes to atherosclerotic diseases and can be regulated via microRNA-dependent mechanisms. We recently identified that asymmetrical dimethylarginine positively correlates to vascular remodeling-based diseases. We hypothesized that asymmetrical dimethylarginine induces smooth muscle cell (SMC) phenotypic change via a microRNA-dependent mechanism.Microarray analysis enabled the identification of downregulation of miR-182-3p in asymmetrical dimethylarginine-treated human aortic artery SMCs. The myeloid-associated differentiation marker (MYADM) was identified as the downstream target of miR-182-3p and implicated to contribute to miR-182-3p knockdown-mediated SMC phenotype change, which was evidenced by the increased proliferation and migration and reduced expression levels of phenotype-related genes in human aortic artery SMCs through the ERK/MAP kinase-dependent mechanism. When inhibiting MYADM in the presence of miR-182-3p inhibitor or overexpressing MYADM in the presence of pre-miR-182-3p, human aortic artery SMCs were reversed to the differentiation phenotype. In vivo, adeno-miR-182-3p markedly suppressed carotid neointimal formation by using balloon-injured rat carotid artery model, specifically via decreased MYADM expression, whereas adeno-miR-182-3p inhibitor significantly promoted neointimal formation. Atherosclerotic lesions from patients with high asymmetrical dimethylarginine plasma levels exhibited decreased miR-182-3p expression levels and elevated MYADM expression levels.miR-182-3p is a novel SMC phenotypic modulator by targeting MYADM.",
        "keywords": [
            "asymmetrical dimethylarginine",
            "atherosclerosis",
            "microRNA",
            "myeloid-associated differentiation marker",
            "smooth muscle cell",
            "vascular remodeling"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.). sunlan2005_2012@sina.com."
            },
            {
                "name": "Yongyi Bai",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Rui Zhao",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Tao Sun",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Ruihua Cao",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Fuyu Wang",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Guorong He",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Wen Zhang",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Ying Chen",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Ping Ye",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            },
            {
                "name": "Guanhua Du",
                "org": "From the State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Beijing, China (L.S., R.Z., G.H., W.Z., Y.C., G.D.); Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China (Y.B., R.C., Y.P.); Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China (T.S.); and Department of Neurosurgery, PLA General Hospital, Haidian District, Beijing, China (F.W.)."
            }
        ],
        "venue": "Arteriosclerosis, thrombosis, and vascular biology",
        "year": 2016
    },
    "6zLqqFTg": {
        "id": "6zLqqFTg",
        "title": "Effects of the effective components group of Xiaoshuantongluo formula on rat acute blood stasis model",
        "abstract": "Effects of the effective components group of Xiaoshuantongluo formula (XECG) on rat acute blood stasis model were studied under the guidance of the concept of effective components group. Rat acute blood stasis model was induced by subcutaneous injection of epinephrine combined with ice water bath. Hemorheology indices such as whole blood viscosity, plasma viscosity, erythrocyte aggregation index and platelet aggregation rate; coagulation parameters including PT, APTT, TT and FIB; 6-keto-PGF1alpha, TXB2 and D-dimer levels were determined to evaluate the effects of XECG. The results showed that XECG significantly reduced ADP-induced platelet aggregation, but showed little influence on the whole blood viscosity, plasma viscosity and erythrocyte aggregation rate. XECG extended PT and TT slightly, but had no effects on APTT and FIB content. D-dimer levels significantly decreased after administration of XECG with a little decrease of TXB2, but the content of 6-keto-PGF1alpha did not change significantly. The results suggest that the role of XECG of anti-aggregation is more prominent.",
        "keywords": [
            "Blood stasis",
            "Effective components group",
            "Hemorheology",
            "Platelet aggregation",
            "Xiaoshuantongluo formula"
        ],
        "authors": [
            {
                "name": "Yan Zhao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xin Yu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li-Li Shi",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Bai-Nian Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shao-Hua Wang",
                "org": "Qingdao Municipal Hospital(Qingdao Municipal Hospital),Qingdao,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2012
    },
    "LgKHfR1p": {
        "id": "LgKHfR1p",
        "title": "Evaluation of Hippocampal Injury and Cognitive Function Induced by Embolization in the Rat Brain: Injury Pattern Induced by Embolization",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "li gao",
                "org": ""
            },
            {
                "name": "zhaohong xuan",
                "org": ""
            },
            {
                "name": "xiaoyan yu",
                "org": ""
            },
            {
                "name": "qiaoyun wang",
                "org": ""
            },
            {
                "name": "lili shi",
                "org": ""
            },
            {
                "name": "bainian chen",
                "org": ""
            },
            {
                "name": "mei gao",
                "org": ""
            },
            {
                "name": "hengai zhang",
                "org": ""
            }
        ],
        "venue": "Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology",
        "year": 2013
    },
    "CbNpUoa9": {
        "id": "CbNpUoa9",
        "title": "Rho/Rho-kinase mediated signalling and statins",
        "abstract": "Except for the beneficial actions on lipid profile,statins exhibit several other effects,which are related to Rho/Rho-kinase mediated signaling.Statins inhibit the isoprenylation and membrane location of Rho and the following activation of Rho kinase,and then trigger a set of cell biological effects.The elucidation of the relationship between statins and Rho/Rho-kinase mediated signaling would help to understand,at least in part,the mechanisms of the extensive pharmaceutical activities of statins besides adjusting lipids.",
        "keywords": [
            "singal transductian",
            "protein-serine-threonine kinases",
            "statins",
            "pharmacologic actions",
            "Rho/Rho-kinase"
        ],
        "authors": [
            {
                "name": "ZHAO Yan",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science.;National Clinical Drug Trial Institution,Qingdao Municipal Hospital,Qingdao SHANDONG ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science."
            },
            {
                "name": "WANG Shao-hua",
                "org": "National Clinical Drug Trial Institution,Qingdao Municipal Hospital,Qingdao SHANDONG ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs and Clinical Remedies",
        "year": 2008
    },
    "yRVbdmz9": {
        "id": "yRVbdmz9",
        "title": "Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats.",
        "abstract": "Because myocardial infarction is a major cause of morbidity and mortality worldwide, protecting the heart from the ischemia is the focus of intense research. Coptisine is an isoquinoline alkaloid extracted form Coptidis Rhizoma. This study aims to elucidate if coptisine is responsible for cardioprotection using myocardial infarction (MI) rat models and investigate its potential mechanism of action.Myocardial infarction was produced in rats with 85 mgkg(-1) isoproterenol administered subcutaneously twice at an interval of 24 h. The rats were randomized into 7 groups: (I) Normal; (II) ISO; (III) ISO+fasudil; (IV) ISO+isosorbide dinitrate (ISDN) and (V-VII) ISO+coptisine (25, 50 and 100 mgkg(-1)). Cardiac function and markers of cardiac ischemic were assessed after MI.Rats pretreated with coptisine (25, 50 and 100 mgkg(-1)) for 21 days and received subcutaneously injected with ISO (85 mgkg(-1)) on the 20th and 21st day at an interval of 24 h. The results suggested that coptisine has strong antioxidant activity, and it can maintain cell membrane integrity, ameliorate mitochondrial respiratory dysfunction, reduce myocardial cells apoptosis, inhibit RhoA/ROCK expression induced by high-dose isoproterenol administration.Coptisine provided cardioprotection in a model of myocardial infarction, and therefore should be considered as a novel adjunctive therapy for attenuating myocardial damage.",
        "keywords": [
            "myocardial infarction",
            "anti-oxidative",
            "mitochondrial respiratory function",
            "rho kinase",
            "isoproterenol",
            "coptisine"
        ],
        "authors": [
            {
                "name": "Li-Li Gong",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Su-Bo Wang",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Jia-Lin Sun",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Xiao-Xiu Li",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Shou-Bao Wang",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            }
        ],
        "venue": "Atherosclerosis",
        "year": 2012
    },
    "HDlrSVaG": {
        "id": "HDlrSVaG",
        "title": "Neuroprotective and antitremor effect of the mixture of luteolin and rutin on 6-hydroxydopamine induced Parkinson's disease in rat models",
        "abstract": "Aim: To explore the neuroprotective and antitremor effect of the complex mixture of luteolin and rutin (MLR) on 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD) in rat models. Methods: PD rat models were established by microinjection of 6-OHDA into the left medial forebrain bundle (MFB). After 2 weeks, the rats were divided into six groups randomly: sham-lesioned rats (control, saline ig), 6-OHDA (saline ig), madopar (50mg·kg -1 ig) , MLR (125 , 250 , 375 mg·kg -1 ig). 3 weeks after MLR treatment, the presence of tremors were assessed. The number of tyrosine hydroxylase (TH) , dopamine transport protein (DAT) , and glial fibrillary acidic protein (GFAP) positive cells were detected by immunohistochemical method. Results: The Electromyography (EMG) recordings revealed the characteristic of muscle activity, MLR could decrease the burst amplitude and burst frequency. The number of THpositive neurons in MLR high-dose group was approximately 5 times more than 6-OHDA group and GFAP-postive astrocyte decreased by 43. 68% compared with 6-OHDA group. Conclusions: MLR can significantly suppress muscle tremor in a dose-dependent manner, and avert neurodegenerative processes. The mechanism of MLR in PD may be related the fact with that it can . provide a protective effect against 6-OHDA-induced loss of dopaminergic (DA) neuron, attenuate astrocyte activation and the release of pro-inflammatory factor.",
        "keywords": [
            "6-Hydroxydopamine",
            "Luteolin",
            "Neuroprotective",
            "Parkinson's disease",
            "Rat",
            "Rutin",
            "Tremor"
        ],
        "authors": [
            {
                "name": "HE Guo-rong",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "CHENG Yin-xia",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xin Mu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "LI Xiao-xiu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xin Yu",
                "org": "Yantai University(Yantai University),Yantai,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "FANG Lian-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2012
    },
    "ybfLKrce": {
        "id": "ybfLKrce",
        "title": "Application of uniform design-high throughput screening to multi-component compatible research of radix salviae miltiorrhizae",
        "abstract": "OBJECTIVE: To evaluate the bioactive components group of Radix Salviae Miltiorrhizae (RXM) by multifactor and multilevel uniform design-high throughput screening method. METHODS: Eleven of bioactive components of RXM (4 of water-solubility and 7 of liposolubility) were recombined to be a new compatible group through uniform design. And the effects were detected by DPPH oxidative methods. RESULTS: After high-throughput screening and rescreening, better water-solubility, better water-solubility add liposolubility, and optimal combination compatibility of RXM were obtained. CONCLUSION: Uniform design-high throughput screening was referred to research bioactive component of compound recipe of traditional Chinese medicine.",
        "keywords": [
            "Multi-component",
            "Proportion",
            "Radix salviae miltiorrhizae",
            "Uniform design-high throughput screening"
        ],
        "authors": [
            {
                "name": "ZHANG Dan-Shen",
                "org": "Hebei North University(Hebei North University),Zhangjiakou,China"
            },
            {
                "name": "ZHANG Tian-Tai",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2009
    },
    "pqME7KwN": {
        "id": "pqME7KwN",
        "title": "The Anti-tumor Effects of Danshen",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiuping chen",
                "org": "peking union medical college"
            },
            {
                "name": "tiantai zhang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "lbhWpTGo": {
        "id": "lbhWpTGo",
        "title": "Targeting the neurovascular unit: development of a new model and consideration for novel strategy for Alzheimer's disease.",
        "abstract": "Alzheimer's disease involves the complex and interconnected cascade of cellular and molecular events. Only a few treatments are available to slow the course of the disease at present. Recent studies suggest that neurovascular unit serves to maintain cerebral homeostasis, and pathological interactions between components of neurovascular unit lead to cerebral dysfunction. In present study, we established a functional unit trying to target major components of the neurovascular unit by the co-culture of rat cortical parenchymal culture and cerebral microvascular endothelial cells. This entity allowed the application of techniques such as immunofluorescent imaging and biological assays under defined conditions. The morphology of cell types, blood-brain barrier function and neuronal activation were investigated. The insight revealed that targeting components of the neurovascular unit, rather than just the neuron, might be a priority in Alzheimer's disease and more likely to provide cerebroprotection.",
        "keywords": [
            "blood–brain barrier",
            "amyloid β peptide",
            "neurovascular unit",
            "alzheimer's disease",
            "cerebral microvascular endothelial cells"
        ],
        "authors": [
            {
                "name": "Rui Liu",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xiannongtan Street, Beijing 100050, PR China"
            },
            {
                "name": "Tian-tai Zhang",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xiannongtan Street, Beijing 100050, PR China"
            },
            {
                "name": "Cai-xia Wu",
                "org": "Shenyang Pharmaceutical University, Shenyang 110016, PR China"
            },
            {
                "name": "Xi Lan",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Xiannongtan Street, Beijing 100050, PR China"
            },
            {
                "name": "Guan-hua Du",
                "org": ""
            }
        ],
        "venue": "Brain research bulletin",
        "year": 2011
    },
    "Dvp08c3Q": {
        "id": "Dvp08c3Q",
        "title": "A study on the standard of influenza neuraminidase inhibition assay",
        "abstract": "In present study, standard method and standard operation practice for measuring the activities of influenza neuraminidase and its inhibitors have been established. The accuracy and stability of the method has been evaluated. Standard operation is as following: 10 microL sample, 30 microL neuraminidase and 60 microL substrate are added to one well of a 96-well plate, and then incubated at 37 degrees C for 1 h. The reaction was stopped with NaOH before fluorescence intensity determination. One unit of neuraminidase is defined as the amount of enzyme that produces 1 nmol 4-MU in 1 h under above conditions. The inhibition accuracy is indicated by an uncertainty measurement of 6.51 x 10(-12), and its stability was reaffirmed by determination of oseltamivir acid. In this study, systematic assessment of neuraminidase inhibitory assay not only provided theoretical basis of its application in drug discovery, but also made preliminary attempt to use uncertainty measurement as a parameter in biological measurement.",
        "keywords": [
            "High throughput screening",
            "Influenza",
            "Neuraminidase",
            "Uncertainty measurement"
        ],
        "authors": [
            {
                "name": "Fan Yang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2012
    },
    "bJF315SQ": {
        "id": "bJF315SQ",
        "title": "Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects.",
        "abstract": "The root of Scutellaria baicalensis Georgi has been used extensively in traditional Chinese medicine for the treatment of inflammation, fever, cough, dysentery, and hypertension. Baicalein is a flavonoid isolated from the root of Scutellaria baicalensis Georgi and is a novel neuroprotective agent under development for the treatment of Parkinson׳s disease. We aimed to investigate the pharmacokinetic (PK) properties of baicalein and its main metabolite, bacalin, after single-dose administration in healthy Chinese subjects. The safety and tolerability of baicalein were also assessed.This was a Phase I, randomized, double-blind, single-dose trial of baicalein (100-2800 mg) in 72 healthy adults. Samples of blood, urine and feces were collected at regular intervals up to 48 h after administration of the study drug. Baicalein and baicalin were then analyzed using liquid chromatography-tandem mass spectrometry (LC/MS/MS). The maximum concentration that the drug achieved after dosing (Cmax), time to Cmax (Tmax), terminal half-life (t₁/₂), area under the curve from time zero to time of last quantifiable concentration (AUC(0, t)), area under the curve from time zero to infinity (AUC(0, ∞)), apparent total plasma clearance (CL/F), and apparent total volume of distribution (V/F) were determined using non-compartmental models. Dose proportion was tested using a method combining the equivalence criterion and power model. Physical examinations, vital signs, ECG findings, hematology, and urinalysis were monitored before and at regular intervals after administration of the study drug.The PK profile of baicelein and baicelin was characterized by a median Tmax of 0.75-3.5 h and 0.5-3 h, respectively, followed by a multiphasic profile with a t₁/₂ of 1.90-15.01 h and 4.22-10.80 h, respectively. The estimates of the proportionality coefficient (90% CI) for Cmax, AUC₀-t and AUC₀-∞ were 0.83 (0.70-0.96), 0.91 (0.81-1.00) and 0.92 (0.82-1.02), respectively. All values overlapped within the pre-specified range of (0.89-1.11), (0.93-1.07), and (0.93-1.07), respectively. Dose proportionality was inconclusive for a baicalein dose range of 100-2800 mg. The total urinary clearance of baicalein and baicalin was <1%. Approximately 27% of baicalein was eliminated as unchanged drug in feces. Baicalein was well tolerated. Eleven treatment-related adverse events were observed, and all were rated as \"mild\" and resolved without further treatment. No serious adverse events occurred.Single oral doses of 100-2800 mg of baicalein were safe and well tolerated by healthy subjects. Clinical laboratory assessments showed no signs of toxicity in the liver or kidney. The favorable safety profile and PK properties warrant further clinical studies for baicalein.",
        "keywords": [
            "baicalein",
            "baicalein (pubchem cid: 5281605)",
            "baicalin",
            "baicalin (pubchem cid:64982)",
            "parkinson׳s disease",
            "pharmacokinetics",
            "safety",
            "tolerability"
        ],
        "authors": [
            {
                "name": "Min Li",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Aixin Shi",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Hongxian Pang",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Wei Xue",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Yang Li",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Guoying Cao",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Bei Yan",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Fan Dong",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Kexin Li",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            },
            {
                "name": "Wei Xiao",
                "org": "StateKey Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, JiangsuKanion Parmaceutical CO. LTD., Lianyungang, Jiangsu 222001, China."
            },
            {
                "name": "Guorong He",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xin Hu",
                "org": "Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical pharmacology, Beijing Hospital of the Ministry of Health, Beijing 100730, China."
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2014
    },
    "MG30BWUr": {
        "id": "MG30BWUr",
        "title": "Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation.",
        "abstract": "Background: White adipose tissue (WAT) browning confers beneficial effects on metabolic diseases. However, visceral adipose tissue (VAT) is not as susceptible to browning as subcutaneous adipose tissue (SAT). Aim: Interpreting the heterogeneity of VAT and SAT in brown remodeling and provide promising lipid targets to promote WAT browning. Methods: We first investigated the effects of beta 3-adrenergic stimulation by CL316,243 on systemic metabolism. Then, high-coverage targeted lipidomics approach with multiple reaction monitoring (MRM) was utilized to provide extensive detection of lipid metabolites in VAT and SAT. Results: CL316,243 notably ameliorated the systemic metabolism and induced brown remodeling of SAT but browning resistance of VAT. Comprehensive lipidomics analysis revealed browning heterogeneity of VAT and SAT with more dramatic alteration of lipid classes and species in VAT rather than SAT, though VAT is resistant to browning. Adrenergic stimulation differentially affected glycerides content in VAT and SAT and boosted the abundance of more glycerophospholipids species in VAT than in SAT. Besides, CL316,243 increased sphingolipids in VAT without changes in SAT, meanwhile, elevated cardiolipin species more prominently in VAT than in SAT. Conclusions: We demonstrated the browning heterogeneity of WAT and identified potential lipid biomarkers which may provide lipid targets for overcoming VAT browning resistance.",
        "keywords": [
            "lipid profiling",
            "white adipose tissue",
            "browning heterogeneity",
            "visceral adipose tissue",
            "subcutaneous adipose tissue"
        ],
        "authors": [
            {
                "name": "Ping He",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Biyu Hou",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Yanliang Li",
                "org": "Univ Illinois, Dept Physiol & Biophys, Coll Med, Chicago, IL 60612 USA"
            },
            {
                "name": "Chunyang Xu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Peng Ma",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Sin Man Lam",
                "org": "Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China"
            },
            {
                "name": "Victoria Gil",
                "org": "Univ Illinois, Dept Physiol & Biophys, Coll Med, Chicago, IL 60612 USA"
            },
            {
                "name": "Xinyu Yang",
                "org": "Guangdong Med Univ, Coll Pharm, Dongguan 523808, Peoples R China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guanghou Shui",
                "org": "Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China"
            },
            {
                "name": "Junke Song",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guifen Qiang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Chong Wee Liew",
                "org": "Univ Illinois, Dept Physiol & Biophys, Coll Med, Chicago, IL 60612 USA"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "BIOMOLECULES",
        "year": 2019
    },
    "v8UVxCaL": {
        "id": "v8UVxCaL",
        "title": " Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice.",
        "abstract": "Myricitrin, a bioactive and natural flavonoids, is well known for its anti-inflammatory and antioxidant properties. However, the anti-neuroinflammation and possible mechanism has not been fully elucidated. Therefore, the present study was to investigate the possible mechanism of its neuroprotection and anti-neuroinflammation in the nigrostriatum of LPS-stimulated mice. The results showed that myricitrin improved neuron injury and raised the expressions of PSD-95 protein and TH protein in the nigrostriatum of LPS-stimulated mice. In addition, myricitrin decreased the production of pro-inflammatory factors including IL-1β, IL-6 and TNFα, decreased the level of chemokine MCP-1, and suppressed the expressions of COX-2 and iNOS. Meanwhile, myricitrin suppressed HMGB1, TLR4, and MyD88 expression in the nigrostriatum of LPS-stimulated mice. Furthermore, myricitrin inhibited NF-κB and MAPK signaling pathways activated by LPS. In conclusion, our studies suggest that myricitrin blocks activation of protects NF-κB and MAPK signaling pathways to nigrostiatum neuron from injury in LPS-stimulated mice and is beneficial to treatment nigrostriatum inflammation of PD.",
        "keywords": [
            "Lipopolysaccharide (LPS)",
            "MAPK",
            "Myricitrin",
            "NF-κB",
            "Neuroinflammation",
            "Nigrostriatum"
        ],
        "authors": [
            {
                "name": "Ying-Lin Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Man Liu",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xiao Cheng",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Wei-Han Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Shan-Shan Zhang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yue-Hua Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: wangyuehua@pku.org.cn."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Journal of neuroimmunology",
        "year": 2019
    },
    "0jZXWnns": {
        "id": "0jZXWnns",
        "title": "Pinocembrin alleviates memory impairment in transient global cerebral ischemic rats.",
        "abstract": "The aim of the present study was to investigate the effect of pinocembrin on cognitive ability impairment in a rat model of transient global cerebral ischemia (TGCI). The TGCI model was established by inducing global cerebral ischemia for 20 min, followed by reperfusion for two weeks. The rats were divided into five experimental groups, including the sham group that were not subjected to ischemia, and four ischemic groups where the rats were exposed to TGCI. The sham and control TGCI groups were administered a vehicle intravenously immediately after reperfusion, while the other three groups were intravenously treated with 1, 5 and 10 mg/kg pinocembrin, respectively. In the present study, neurological scores were analyzed at 0 and 24 h after reperfusion, and the effect of pinocembrin on cognitive ability impairment in the TGCI rat model was investigated using a Morris water maze test. Neuronal loss was observed under an optical microscope with the assistance of Nissl staining. In addition, glial fibrillary acidic protein (GFAP)-positive cells were observed under an optical microscope by an immunohistochemistry assay. Pinocembrin treatment was found to alleviate the cognitive impairments, decrease the neurological scores, diminish neuronal loss in the hippocampus and reduce the number of GFAP-positive cells in the hippocampal CA1 region of the TGCI rats. Therefore, pinocembrin alleviated memory impairment in the TGCI rats.",
        "keywords": [
            "cognition impairment",
            "neuronal loss",
            "pinocembrin",
            "transient global cerebral ischemia",
            "cell cycle",
            "apoptosis",
            "cell",
            "molecular medicine",
            "oncology",
            "cancer",
            "gene"
        ],
        "authors": [
            {
                "name": "Fanrui Meng",
                "org": "College of Pharmacy, Liaoning University, Shenyang, Liaoning 110036, P.R. China ; National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China."
            },
            {
                "name": "Yuehua Wang",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China."
            },
            {
                "name": "Rui Liu",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China."
            },
            {
                "name": "Mei Gao",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China."
            },
            {
                "name": "Guanhua DU",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China."
            }
        ],
        "venue": "Experimental and therapeutic medicine",
        "year": 2014
    },
    "QG26TH7a": {
        "id": "QG26TH7a",
        "title": "A new methodology that improves the neuroprotective properties of the traditional Chinese medicine prescription, NaoDeSheng",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "li zhang",
                "org": ""
            },
            {
                "name": "xinrui cheng",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "2ATIUN0u": {
        "id": "2ATIUN0u",
        "title": "Comparison of HPLC and optical rotation photometry methods in determination of arginine in ibuprofen injection",
        "abstract": "Objective To establish an effective and reliable determination method for determination of the content of arginine in ibuprofen injection through comparing HPLC and optical rotation photometry methods.Methods Kromasil NH2 column(250 mm×4.6 mm,5 μm)was used in HPLC method with the mobile phase consisted of acetonitrile-20 mmol · L-1 dipotassium hydrogenphosphate solution(V∶ V=57∶ 43).The flow rate of mobile phase was 1.0 mL · min-1,the UV detection wavelength was set at 214 nm and the column temperature was at 30 ℃;Optical rotation of ibuprofen injection was determined according to appendixes Ⅵ E of Chinese Pharmacopoeia 2010 edition.Results HPLC method:The calibration curve was linear within the range of 0.078 to 0.780 g · L-1(A=8.016×104ρ-1.039×103,r=0.999 8,n=6);the lowest limit determination was 150 ng(S/N=3).The mean recoveries of high,middle and low concentration were 99.72%(n=9,RSD=0.45%).Optical rotation photometry method:The calibration curve was linear within the range of 63.0 to 101.0 g · L-1(α=104.5ρ-3.039,r=0.999 7,n=6);The mean recoveries of high,middle and low concentration were 99.10%(n=9,RSD=0.58%).Conclusions Two methods are accurate and suitable for determination of the content of arginine.The optical rotation photometry method is simple.",
        "keywords": [
            "arginine",
            "HPLC",
            "ibuprofen injection",
            "optical rotation photometry"
        ],
        "authors": [
            {
                "name": "HAO Ling-hua",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "QI Yan",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "YANG Qing-yun",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "SHENG Xiao-feng",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "WU Song",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Journal of Shenyang Pharmaceutical University",
        "year": 2013
    },
    "If0IBrKV": {
        "id": "If0IBrKV",
        "title": "Luteolin isolated from the medicinal plant Elsholtzia rugulosa (Labiatae) prevents copper-mediated toxicity in β-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells.",
        "abstract": "Luteolin, a 3',4',5,7-tetrahydroxyflavone, is a plant flavonoid and pharmacologically active agent that has been isolated from several plant species. In the present study, the effects of luteolin obtained from the medicinal plant Elsholtzia rugulosa and the related mechanisms were examined in an Alzheimer's disease (AD) cell model. In this model, copper was used to exacerbate the neurotoxicity in β-amyloid precursor protein Swedish mutation stably overexpressed SH-SY5Y cells (named \"APPsw cells\" for short). Based on this model, we demonstrated that luteolin increased cell viability, reduced intracellular ROS generation, enhanced the activity of SOD and reversed mitochondrial membrane potential dissipation. Inhibition of caspase-related apoptosis was consistently involved in the neuroprotection afforded by luteolin. Furthermore, it down-regulated the expression of AβPP and lowered the secretion of Aβ₁₋₄₂. These results indicated that luteolin from the Elsholtzia rugulosa exerted neroprotective effects through mechanisms that decrease AβPP expression, lower Aβ secretion, regulate the redox imbalance, preserve mitochondrial function, and depress the caspase family-related apoptosis.",
        "keywords": [
            "amyloid-β peptide",
            "copper",
            "elsholtzia rugulosa",
            "alzheimer's disease",
            "luteolin"
        ],
        "authors": [
            {
                "name": "Rui Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fanrui Meng",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Ailin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hailin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xi Lan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lin Li",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2011
    },
    "B0AagH6V": {
        "id": "B0AagH6V",
        "title": "Protective Effect of Extracts from Radix et Rhizoma Rhei and Alisma orientalis against Acute Kidney Injury Induced by Diethylene Glycol",
        "abstract": "OBJECTIVE:To explore the protective effect of the extracts from Radix et Rhizoma Rhei and Alisma orientalis against acute kidney injury induced by diethylene glycol (DEG) and its action mechanism. METHODS: The acute kidney injury model of mice was induced by intragastric administration of DEG. Then the model mice were administered intragastrically with the extracts of Radix et Rhizoma Rhei and Alisma orientalis. Serum levels of creatinine(Cr) and blood urea nitrogen (BUN), the activities of superoxide dismutase (SOD) and glutathione peroxidase(GSH-PX) and the content of malonaldehyde(MDA) were determined. RESULTS: After administration of DEG, the mice presents with obvious toxic reactions including the increase of the ratio of kidney to body weight, the increase of serum levels of BUN and Cr, the decrease of the activities of SOD and GSH-PX in kidney tissue, the increase of the content of MDA. However, after treatment with the extracts of Radix et Rhizoma Rhei and Alisma orientalis, the toxic symptoms in mice were attenuated markedly, the ratio of kidney to body weight decreased, serum levels of BUN and Cr decreased significantly, the activities of SOD and GSH-PX in renal tissues increased and the content of MDA decreased. CONCLUSION: The remarkable protective effect of the extracts from Radix et Rhizoma Rhei and Alisma orientalis against DEG-induced acute kidney injury in mice might be related to its actions of improving the activity of antioxidase of kidney while inhibiting lipid peroxidation.",
        "keywords": [
            "Extract from Radix et Rhizoma Rhei",
            "Diethylene glycol",
            "Extract from Alisma orientalis",
            "Kidney injury",
            "Lipid peroxidation"
        ],
        "authors": [
            {
                "name": "ZHU Shen-yin",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical University, Beijing , China"
            },
            {
                "name": "ZHOU Yuan-da",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical University, Beijing , China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical University, Beijing , China"
            }
        ],
        "venue": "China Pharmacy",
        "year": 2009
    },
    "9Pr3DuQv": {
        "id": "9Pr3DuQv",
        "title": "Synthesis and hypoglycemic activity of 5-hydroxylmethyl-2-furfural derivatives",
        "abstract": "5-Hydroxylmethyl-2-furfural(5-HMF) is the active ingredient of traditional Chinese medicine Trichosanthes kirilowii,which could lower the level of glycemic,so it is effective agents for the treatment of diabetes in clinic.However,it was reported that 5-HMF may have a weak cytotoxic,mutagenic,carcinogenic and other toxic side.The aim of this study is to discover new hypoglycemic drugs with high activities.Based on the structure of 5-HMF,fourteen new compounds were synthesized via condensation,esterification,protection and deprotection,whose structures were confirmed by 1H-NMR and MS.Eight compounds(1-7,14) were detected in vitro for hypoglycemic activity by observing their effects on absorption rate of glucose,all of them showed certain activities at 10 μg · mL-1 concentration,among which compound 6 exhibited the strongest hypoglycemic activity to insulin with 87.45% absorption rate of glucose.The activity was much better than the parent compound 5-HMF.The structure-activity relationship of its derivatives as a novel of hypoglycemic drugs will be investigated further.",
        "keywords": [
            "hypoglycemic activity",
            "5-hydroxylmethyl-2-furfural derivative",
            "synthesis"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": "College of Pharmaceutical Sciences,Inner Mongoila Medical College,Huhehaote ,China"
            },
            {
                "name": "LIAO Xiang-wei",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Pharmaceutical Products,Ministry of Health of PRC,Beijing City Key Laboratory of Active Substance Discovery and Drug Evaluation,Beijing ,China"
            },
            {
                "name": "WU Song",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Pharmaceutical Products,Ministry of Health of PRC,Beijing City Key Laboratory of Active Substance Discovery and Drug Evaluation,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Pharmaceutical Products,Ministry of Health of PRC,Beijing City Key Laboratory of Active Substance Discovery and Drug Evaluation,Beijing ,China"
            },
            {
                "name": "HAO Ling-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Pharmaceutical Products,Ministry of Health of PRC,Beijing City Key Laboratory of Active Substance Discovery and Drug Evaluation,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Medicinal Chemistry",
        "year": 2012
    },
    "GoUdP0G2": {
        "id": "GoUdP0G2",
        "title": "The Anti-ulcer Effect of Tibet Medicine of Gentiana macrophylla",
        "abstract": "ObjectiveTo study the anti-ulceration effect of Gentiana macrophylla from Tibet,and the mechanism of action.MethodsWe studied the effect of the Gentiana macrophylla ethanol extract on aspirin and absolute ethylalcohol-induced rat gastric ulcer models.ResultsThe results showed that the Gentiana macrophylla ethanol extract could significantly dwindle the areas of the gastric ulcer models.It could reduce the total quantity of gastric juice and the secrte of gastric protein if the quantity of Gentiana macrophylla ethanol extract were enough.There was no difference between them and control.ConclusionThe Gentiana macrophylla ethanol extract could prevent gastric ulcer and the mechanism need further research.",
        "keywords": [
            "Tibet medicine",
            "Gentiana macrophylla",
            "Gastric ulcer"
        ],
        "authors": [
            {
                "name": "SUN Fang-yun",
                "org": "Medical Department of Tibet National College,Xianyang ,China"
            },
            {
                "name": "ZHANG Bin",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LIU Qing-shan",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "He Guo-rong",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "CHEN Xiu-ping",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "QIN Hai-lin",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences& Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "LiShiZhen Medicine and Materia Medica Research",
        "year": 2006
    },
    "8seHr8Wv": {
        "id": "8seHr8Wv",
        "title": "The Protective Effect of 3-Deoxysappanchalcone on In Vitro Influenza Virus-induced Apoptosis and Inflammation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "yitao wang",
                "org": ""
            },
            {
                "name": "simon lee",
                "org": ""
            },
            {
                "name": "hailin qin",
                "org": ""
            },
            {
                "name": "ailin liu",
                "org": ""
            },
            {
                "name": "weiling zhou",
                "org": ""
            },
            {
                "name": "fan yang",
                "org": ""
            }
        ],
        "venue": "Planta Medica",
        "year": 2012
    },
    "VP6ASioJ": {
        "id": "VP6ASioJ",
        "title": "Methods for in vitro assessment of neurotoxicants",
        "abstract": "Neurotoxicity is the most common adverse drug reaction seen in clinic.The nervous system is more sensitive to internal and external toxic attacks.Therefore,neurotoxicants may exert more serious effects than general toxic chemicals.At present,in vitro neurotoxicity assessment is mainly applied in early pharmaceutical screening and toxic mechanism study.Neurotoxic tests are performed on the basis of different kinds of cell and tissue culture systems.As the complexity of the culture systems increases,cells in these systems gain more features resembling those in vivo.Endpoints used in these tests usually involve general cytotoxicity,morphological changes associated with neurite outgrowth and parameters of specific neurotoxicity.",
        "keywords": [
            "neurochemistry",
            "nervous system/toxicity",
            "cell culture techniques",
            "neurons"
        ],
        "authors": [
            {
                "name": "XU Bei",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry ofEducation,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-Hua",
                "org": "Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry ofEducation,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Pharmacology and Toxicology",
        "year": 2008
    },
    "LDYFoMqO": {
        "id": "LDYFoMqO",
        "title": "The mRNA expression of renal aquaporin-2 in rats with diabetes mellitus and the therapeutical effect of astragalus membranaceus",
        "abstract": "Aim: To investigate the changes of renal medullary aquaporin-2 (AQP-2) in rats with diabetes mellitus (DM) induced by streptozotocin (STZ) and the therapeutical effect of astragalus membranaceus (AM). Methods: Thirty diabetes mellitus rats induced by STZ were randomly divided into three groups: DM group, AM low dosage group (5 g·kg -1·d -1), AM high dosage group (10 g·kg -1·d -1). Another 10 normal rats were taken as the control group. The drug was given by intraperitonial injection for 6 weeks. Blood glucose, serum insulin and C-Peptide were recorded. A 24 h urine collection through metabolic cage was made to measure urinary volume; the RT-PCR technique was used to determine the levels of aquaporin-2 mRNA expression in kidney medulla. Results: After STZ treatment, diabetic rats showed higher glucose and lower insulin, C-Peptide levels as compared with control rats. AM treatment had no effect on blood glucose, serum insulin and C-Peptide, but it could significantly increase the urinary volume of diabetic rats. The expression of AQP-2 mRNA was up-regulated in renal medulla of diabetic rats, AM treatment could alleviate the exprssion of AQP-2 mRNA. Conclusion: The therapeutical effect of AM on diabetes mellitus may be related to the significantly decreased expression of AQP-2 in the kidney medulla.",
        "keywords": [
            "Aquaporin-2",
            "Astragalus membranaceus",
            "Diabetes mellitus",
            "RT-PCR",
            "Urinary volume",
            "Water metabolism"
        ],
        "authors": [
            {
                "name": "Xin Mu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xia Yuan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Bai Kang",
                "org": "Weifang Medical College(Weifang Medical College),Weifang,China"
            },
            {
                "name": "HE Guo-rong",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2010
    },
    "nAnEpMVT": {
        "id": "nAnEpMVT",
        "title": "Development of new reference material neohesperidin for quality control of dietary supplements: Development of new reference material neohesperidin",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ningbo gong",
                "org": ""
            },
            {
                "name": "baoxi zhang",
                "org": ""
            },
            {
                "name": "dezhi yang",
                "org": ""
            },
            {
                "name": "zhaolin gao",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "yang lu",
                "org": ""
            }
        ],
        "venue": "Journal of the Science of Food and Agriculture",
        "year": 2014
    },
    "d9YCldpT": {
        "id": "d9YCldpT",
        "title": "Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rat",
        "abstract": "",
        "keywords": [
            "mass spectrometry",
            "gas chromatography"
        ],
        "authors": [
            {
                "name": "xiaoxia gao",
                "org": ""
            },
            {
                "name": "xingyu zheng",
                "org": ""
            },
            {
                "name": "zhenyu li",
                "org": ""
            },
            {
                "name": "yuzhi zhou",
                "org": ""
            },
            {
                "name": "haifeng sun",
                "org": ""
            },
            {
                "name": "lizeng zhang",
                "org": ""
            },
            {
                "name": "xiaoqing guo",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            }
        ],
        "venue": "The Lancet",
        "year": 2011
    },
    "zJg8krru": {
        "id": "zJg8krru",
        "title": "Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabolomics approach coupled with multivariate analysis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "junsheng tian",
                "org": "shanxi university"
            },
            {
                "name": "caichun liu",
                "org": "shanxi university"
            },
            {
                "name": "huan xiang",
                "org": "shanxi university"
            },
            {
                "name": "xiaofen zheng",
                "org": "shanxi university"
            },
            {
                "name": "guojiang peng",
                "org": "shanxi university"
            },
            {
                "name": "xiang zhang",
                "org": "university of louisville"
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": "shanxi university"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "xGE1emIm": {
        "id": "xGE1emIm",
        "title": "ERK1/2 and JNK are involved in the inhibitory effect of DL0805 on vasoconstriction induced by angiotensin Ⅱ in the rat thoracic aortic rings",
        "abstract": "Objective To observe the effect of DL0805(a Rho kinase inhibitor) on angiotensin Ⅱ(Ang Ⅱ)-induced vascular contractions in the rat thoracic aortic rings and to investigate the possible mechanism.Methods The isometric vascular tone was measured in both endothelium-intact and endothelium-denuded rat thoracic aortic rings.Phosphorylations of p44/42 extracellular signal-regulated kinase(ERK1/2) and c-Jun amino-terminal kinase(JNK),and protein level of angiotensin type 1 receptor(AT1R) in rat aortic rings were detected by Western blot.Results DL0805(10,25 and 50 μmol/L) inhibited Ang Ⅱ(100 nmol/L)-induced vascular contractions in both endothelium-intact and endothelium-denuded rat aortic rings in a dose dependent way(P<0.01,P<0.001).Furthermore,activation of ERK1/2 and JNK by Ang Ⅱ(100 nmol/L)stimulation was significantly inhibited by DL0805(25 and 50 μmol/L) in both endothelium-intact and-denuded rat aortic rings(P<0.05,P<0.01 and P<0.001).However,the protein level of AT1R in response to Ang Ⅱ was not affected by DL0805(5,25 and 50 μmol/L) in rat aortic rings.Conclusions DL0805 inhibits Ang Ⅱ-induced rat aortic rings contraction and the mechanism involves the inhibition of Ang Ⅱ-induced ERK1/2 and JNK activation.",
        "keywords": [
            "JNK",
            "ERK1/2",
            "DL0805",
            "angiotensin Ⅱ",
            "rat thoracic aortic rings"
        ],
        "authors": [
            {
                "name": "LI Li",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "YUAN Tian-yi",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "YANG Hai-guang",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "XU Huan-li",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "WANG Le",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "YAN Yu",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            }
        ],
        "venue": "Basic & Clinical Medicine",
        "year": 2013
    },
    "xNmVmyUd": {
        "id": "xNmVmyUd",
        "title": "Pharmacokinetic comparison of two ozagrel polymorph forms in SD rats]",
        "abstract": "To enhance the quality and efficiency of ozagrel by investigating the differences between the ozagrel polymorphs in bioavailability. Solid ozagrel in different polymorph forms were orally administered to SD rats. An HPLC method was established to determinate plasma level of ozagrel. The bioavailabilities of two polymorph forms were calculated and compared. The pharmacokinetic parameters of ozagrel, were as follows: Cmax was 32.72 ± 17.04 and 34.01 ± 19.13 mg · L(-1), respectively; AUC0-t was 61.14 ± 14.76 and 85.56 ± 18.08 mg · L(-1) · h, respectively; t½ was 1.53 ± 0.51 and 4.73 ± 3.00 h, respectively. There was no significant difference in pharmacokinetic parameters between form I and II polymorphs of ozagrel while the t½ of form II is longer, which indicates that the use of form II polymorph as pharmaceutical product may prolong the effective action time in clinics. This would help the polymorph quality control in drug production.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhi-Zhen Qin",
                "org": ""
            },
            {
                "name": "Qian-Xi Chen",
                "org": ""
            },
            {
                "name": "Jun-Ke Song",
                "org": ""
            },
            {
                "name": "Yang Lü",
                "org": ""
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2015
    },
    "H1eDB3j5": {
        "id": "H1eDB3j5",
        "title": "Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy: Antidepressant effect of Xiaoyaosan on CUMS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaojie liu",
                "org": ""
            },
            {
                "name": "yuzhi zhou",
                "org": ""
            },
            {
                "name": "zhongfeng li",
                "org": ""
            },
            {
                "name": "jie cui",
                "org": ""
            },
            {
                "name": "xiaoxia gao",
                "org": ""
            },
            {
                "name": "haifeng sun",
                "org": ""
            },
            {
                "name": "lizeng zhang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            }
        ],
        "venue": "Journal of Pharmacy and Pharmacology",
        "year": 2012
    },
    "i4CM2OJ4": {
        "id": "i4CM2OJ4",
        "title": "Vasodilation effect of quercetin on rat thoracic aorta and its mechanisms",
        "abstract": "AIM To investigate the vasodilation effect and the related mechanisms of quercetin. METHODS Tension was measured to evaluate the vasodilation effect of quercetin on rat endothelium-intact and endothelium-denuded thoracic aorta rings.The nitric oxide synthase inhibitor N~ω-nitro-L-arginine methyl ester (L-NAME),guanylyl cyclase inhibitor methylene blue,cyclooxygenase inhibitor indomethacin,calciumactivated potassium channel blocker tetraethyl ammonium(TEA),ATP-sensitive potassium channel blocker glibencla- mide and voltage-dependent potassium channel blocker 4-aminopyridine(4-AP) were used to illustrate the mechanisms of vasodilation effect of quercetin.RESULTS Quercetin(1,3,10,30,100,300μmol·L~(-1)) relaxed aortic rings pre-contracted with norepinephrine(NE,1μmol·L~(-1)) or KCl(80 mmol-L\"1).Pretreatment with quercetin noncompetitively inhibited contractile responses of aortas to NE or KCl.The vasorelaxant effect of quercetin did not rely on intact endothelia(P>0.05).Pretreatment with L-NAME(100μmol·L~(-1)) significantly reduced the quercetin-induced vasodilation(P<0.05).However,methylene blue(10μmol·L~(-1)) and indomethacin (5μmol·L~(-1)) showed no significant inhibit effects(P>0.05).In endothelium-denuded rings,TEA (5 mmol·L~(-1)) significantly attenuated the vasorelaxant effect of quercetin,while glibenclamide(10μol·L~(-1)) and 4-AP(100μmol·L~(-1)) had no impact on it(P>0.05).CONCLUSION The results suggested that quercetin induced relaxation in rat aortic rings through an endothelium-independent manner by blockade of Ca~(2+) channels.The opening of calcium-activated K~+ channels in vascular smooth muscle cells might also be one of the mechanisms.",
        "keywords": [
            "quercetin",
            "nitric oxide",
            "thoracic",
            "vasodilation",
            "aorta"
        ],
        "authors": [
            {
                "name": "ZHAO Yan",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,BEIJING ,China;Qingdao Municipal Hospital, Qingdao SHANDONG ,China"
            },
            {
                "name": "CHEN Bai-nian",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,BEIJING ,China"
            },
            {
                "name": "WANG Shao-hua",
                "org": "Qingdao Municipal Hospital, Qingdao SHANDONG ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,BEIJING ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs and Clinical Remedies",
        "year": 2011
    },
    "Bt0rNasc": {
        "id": "Bt0rNasc",
        "title": "Study on the Chemical Constituents of Caesalpinia sappan",
        "abstract": "Nine compounds were isolated from the heartwood of Caesalpinia sappan L..On the basis of spectral data,they were identified as brazilein(1),brazilin(2),(±)-lyoniresinol (3),stearic acid(4),stigmasterol(5),(E)-3,3′-dimethoxy-4,4′-dihydroxystilbene(6),(-)-syringaresinol(7),protosappanin A(8),and brazilide(9).Among them,compounds 3,6 and 7 were obtained from this genus for the first time.",
        "keywords": [
            "stilbene",
            "lignin",
            "Caesalpinia sappan",
            "brazilin"
        ],
        "authors": [
            {
                "name": "SHU Shi-hui",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education"
            },
            {
                "name": "ZHANG Li",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,National Center for Pharmaceutical Screening,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,National Center for Pharmaceutical Screening,Beijing ,China"
            },
            {
                "name": "QIN Hai-lin",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2007
    },
    "pPGgSRvr": {
        "id": "pPGgSRvr",
        "title": "Protective effects of baicalein against rotenone-induced neurotoxicity in PC12 cells and isolated rat brain mitochondria.",
        "abstract": "Baicalein is one of the major flavonoids obtained from the Scutellaria root. Previous pharmacological studies found that baicalein had neuroprotective effects in animal models of Parkinson's disease. The purpose of this paper was to explore the molecular mechanism of the action of baicalein on PC12 cells and isolated rat brain mitochondria. Firstly, we investigated the effects of baicalein on rotenone-induced toxicity in PC12 cells. The results showed that baicalein suppressed rotenone-induced apoptosis, and inhibited the accumulation of reactive oxidant species, ATP deficiency, mitochondrial membrane potential dissipation, and caspase-3/7 activation in a concentration-dependent manner, indicating that baicalein likely improved mitochondrial function. Furthermore, we used isolated rat brain mitochondria to evaluate the effect of baicalein. Treatment with baicalein prevented rotenone-induced reactive oxidant species production, ATP deficiency and mitochondrial swelling in isolated brain mitochondria. Interestingly, exposure of isolated mitochondria to baicalein promoted mitochondrial active respiration. These results suggest that baicalein may be a mitochondria-targeted antioxidant and exerts neuroprotective effects on rotenone-induced neurotoxicity. This study supports our previous research that baicalein possesses neuroprotective activity in vivo and it is worthy of further study.",
        "keywords": [
            "baicalein",
            "parkinson's disease",
            "oxidative stress",
            "mitochondrial dysfunction",
            "rotenone"
        ],
        "authors": [
            {
                "name": "Xiao-xiu Li",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Guo-rong He",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Xin Mu",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Bei Xu",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Shuo Tian",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Xin Yu",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Fan-rui Meng",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Zhao-hong Xuan",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            },
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica Chinese Academy of Medical Sciences(Institute of Materia Medica ^),Beijing,China"
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2012
    },
    "9wuKwzgn": {
        "id": "9wuKwzgn",
        "title": "Solubility and Pharmacokinetics Study of Valacyclovir Hydrochloride",
        "abstract": "Objective To study the bioavailability and solubility of valacyclovir hydrochloride for enhancing quality standards.Methods The solubility was determined and compared for the crystal form Ⅰ,Ⅳ,Ⅷ of valacyclovir hydrochloride,the latter of which were administered to SD rats at the dose of 100 mg·kg-1.And a HPLC method was established to test the plasma level of valacyclovir hydrochloride.Results The form Ⅷ was the most soluble form among the three forms in the six solvents.The indirect pharmacokinetic parameters of acyclovir,as the metabolites of the form Ⅰ,Ⅳ,Ⅷ of valacyclovir hydrochloride were as follows: Cmax was(10.304±5.246),(9.321±3.701) and(10.365±6.787) mg·L-1,respectively(P>0.05);AUC0→t was(20.167±1.775),(22.337±5.166) and(20.289±7.845) mg·L-1·h,respectively(P>0.05).Conclusion There is certain difference in solubility of valacyclovir hydrochloride among form Ⅰ,form Ⅳ and form Ⅷ,but no significant difference is found in biological actions in the body among them.",
        "keywords": [
            "Valacyclovir",
            "Pharmacokinetic",
            "Solubility",
            "Polymorphs",
            "hydrochloride"
        ],
        "authors": [
            {
                "name": "HU Fan",
                "org": ""
            },
            {
                "name": "ZHAO Rui",
                "org": ""
            },
            {
                "name": "ZHANG Li",
                "org": ""
            },
            {
                "name": "SONG Jun-ke",
                "org": ""
            },
            {
                "name": "y L",
                "org": ""
            },
            {
                "name": "DU Guan-hua",
                "org": ""
            }
        ],
        "venue": "Herald of Medicine",
        "year": 2012
    },
    "KJpLkOrb": {
        "id": "KJpLkOrb",
        "title": "Neuroprotective effect of baicalein in patients with Parkinson's disease]",
        "abstract": "Baicalein, a flavonoid compound extracted from dried roots of traditional Chinese medicine Scutellaria baicalensis, has been widely applied as an antioxidant and anti-inflammatory agent. With continuous studies on its mechanisms, recent findings suggest that baicalein has some effect on neuroprotection and improvement of clinical symptoms in neurodegenerative diseases such as Parkinson's disease. Recent studies showed that its neuroprotective efficacy is closely related to such functions as antiinflammatory, antioxidative stress, protecting chondriosome, inhibiting glutamate neurotoxicity, promoting nerve growth and inhibiting alpha-synuclein protein-aggregate activities. The aim of this article is to summarize the neuroprotective effects of baicalein in Parkinson's disease.",
        "keywords": [
            "baicalein",
            "parkinson's disease",
            "neuroprotective effect"
        ],
        "authors": [
            {
                "name": "Xin Yu",
                "org": "Department of Pharmacology,School of Pharmacy,Yantai University,Yantai ,China"
            },
            {
                "name": "Guorong He",
                "org": "Beijing Key laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2012
    },
    "lnE6nJFF": {
        "id": "lnE6nJFF",
        "title": "Vasorelaxant effect of Rho kinase inhibitor DL0805 on isolated rat thoracic aortic rings stimulated by angiotensin Ⅱ and its underlying mechanisms",
        "abstract": "Aim To investigate the vasorelaxant effect of DL0805,a Rho kinase inhibitor,on the rat thoracic aortic rings stimulated by angiotensin Ⅱ(Ang Ⅱ) and to explore its underlying mechanisms.Methods The isotonic contractions of the thoracic aortic rings from SD rats were recorded,and the effects of DL0805 on the single dose and concentration cumulative response curves of Ang Ⅱ were recorded.Phosphorylations of myosin light chain 2(MLC2) in rat aortic rings were detected by Western blot.Results DL0805 exerted vasorelaxation in a dose-dependent manner in Ang Ⅱ(100 nmol·L-1)-induced contraction and partial loss of the vasorelaxation in endothelium-denuded rings.DL0805(25,50 μmol · L-1) shifted the concentration-response curve of Ang Ⅱ to right with non-parallel manner.The maximal response to Ang Ⅱ was depressed progressively and the pD' 2 value was 4.65 ± 0.04.DL0 8 0 5(2 5,5 0 μmol · L-1) significantlyattenuated the increased MLC2 phosphorylation level in the aortic rings stimulated by Ang Ⅱ(100 nmol·L- 1). Conclusion DL0805 induces relaxation in the rat aortic rings stimulated by Ang Ⅱ and the mechanism involves the inhibition of Ang Ⅱ-induced MLC2 activation via blocking angiotensin Ⅱ type 1 receptor(AT1R).",
        "keywords": [
            "MLC2",
            "AT1R",
            "DL0805",
            "angiotensin Ⅱ",
            "Rho kinase",
            "rat thoracic aortic rings"
        ],
        "authors": [
            {
                "name": "LI Li",
                "org": ""
            },
            {
                "name": "GUO Jing",
                "org": ""
            },
            {
                "name": "YUAN Tian-yi",
                "org": ""
            },
            {
                "name": "CHEN Bai-nian",
                "org": ""
            },
            {
                "name": "FANG Lian-hua",
                "org": ""
            },
            {
                "name": "GONG Li-li",
                "org": ""
            },
            {
                "name": "DU Guan-hua",
                "org": ""
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2013
    },
    "Qo3ihkVr": {
        "id": "Qo3ihkVr",
        "title": "1 H NMR-based metabolic profiling of liver in chronic unpredictable mild stress rats with genipin treatment",
        "abstract": "",
        "keywords": [
            "metabolomics",
            "nuclear magnetic resonance",
            "depression"
        ],
        "authors": [
            {
                "name": "jianli chen",
                "org": ""
            },
            {
                "name": "biyun shi",
                "org": ""
            },
            {
                "name": "huan xiang",
                "org": ""
            },
            {
                "name": "wenjing hou",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            },
            {
                "name": "junsheng tian",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "Journal of Pharmaceutical and Biomedical Analysis",
        "year": 2015
    },
    "fvVrWF1r": {
        "id": "fvVrWF1r",
        "title": "Activity evaluation of components and preparation of effective components group of Xiaoxuming decoction for anti-cerebral ischemic",
        "abstract": "Objective: On basis of preliminary studies, to prepare the effective components group of Xiaoxuming decoction for anti-ischemic by combining chemical analysis with pharmacological activity screening. Method: Free radical scavenging was assayed by DPPH method; the cell viability injured by hydrogen peroxide, L-glutamate, and hypoxia was determined by MTT assay; TBA method was used to determine mitochondrial lipid peroxidation.' Result: Comprehensive analysis of multi-target results, the comprehensive activities of 40% ethanol elution and the middle layer were the highest. Conclusion: 40% ethanol elution and the middle layer were proportionally mixed as the effective components group of Xiaoxuming decoction.",
        "keywords": [
            "Cerebral ischemic",
            "Effective components group",
            "Xiaoxuming decoction"
        ],
        "authors": [
            {
                "name": "Yuehua Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hailin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiaoli He",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2011
    },
    "uOuv5cAP": {
        "id": "uOuv5cAP",
        "title": "Anti-inflammation effect of methyl salicylate 2-O-β-D-lactoside on adjuvant induced-arthritis rats and lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells.",
        "abstract": "Methyl salicylate 2-O-β-D-lactoside (MSL) is a derivative of natural salicylate isolated from Gaultheria yunnanensis (Franch.) Rehder, which is widely used for treating rheumatoid arthritis (RA), swelling and pain. The aim of the present study was to investigate the effect of MSL on the progression of adjuvant-induced arthritis (AIA) in rat in vivo and explore the anti-inflammatory effects and mechanism of MSL in lipopolysaccharide (LPS)-treated murine macrophages RAW264.7 cells in vitro. Our results showed that MSL significantly inhibited the arthritis progression in AIA rats, decreasing the right hind paw swelling and ankle diameter, attenuating histopathological changes and suppressing the plasma levels of TNF-α and IL-1β in AIA rats. Besides, MSL had potent anti-inflammatory effects on the LPS-activated RAW264.7. MSL dose-dependently inhibited the activity of COX-1, and COX-2. Moreover, MSL prominently inhibited LPS-induced activation of MAPK in RAW264.7 cells by blocking phosphorylation of p38 and ERK. Our study suggests that MSL may be effective in the treatment of inflammatory diseases by inhibiting the pro-inflammatory cytokine production and regulating the MAPK signal pathway.",
        "keywords": [
            "Adjuvant-induced arthritis",
            "Cyclooxygenase",
            "MAPK signaling pathway",
            "Methyl salicylate 2-O-β-D-lactoside",
            "Prostaglandin E(2)"
        ],
        "authors": [
            {
                "name": "Xue Zhang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Jialin Sun",
                "org": "Pharmacy Department of the Affiliated Hospital of Qingdao University, Qingdao 266003, China."
            },
            {
                "name": "Wenyu Xin",
                "org": "Binzhou Medical University, Yantai 264003, China."
            },
            {
                "name": "Yongjie Li",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Lin Ni",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Xiaowei Ma",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Dan Zhang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Dongming Zhang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Tiantai Zhang",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Peking Union Medical College &amp; Chinese Academy of Medical Sciences, Beijing 100050, China."
            }
        ],
        "venue": "International immunopharmacology",
        "year": 2015
    },
    "UtPQtNcF": {
        "id": "UtPQtNcF",
        "title": "Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy.",
        "abstract": "Metabolic changes associated with diabetes are reported to lead to the onset of early-stage diabetic nephropathy (DN). Furthermore, lipotoxicity is implicated in renal dysfunction. Most studies of DN have focused on a single or limited number of lipids, and the lipidome of the kidney during early-stage DN remains to be elucidated. In the present study, we aimed to comprehensively identify lipid abnormalities during early-stage DN; to this end, we established an early-stage DN rat model by feeding a high-sucrose and high-fat diet combined with administration of low-dose streptozotocin. Using a high-coverage, targeted lipidomic approach, we established the lipid profile, comprising 437 lipid species and 25 lipid classes, of the kidney cortex in normal rats and the DN rat model. Our findings additionally confirmed that the DN rat model had been successfully established. We observed distinct lipidomic signatures in the DN kidney, with characteristic alterations in side chain composition and degree of unsaturation. Glyceride lipids, especially cholesteryl esters, showed a significant increase in the DN kidney cortex. The levels of most phospholipids exhibited a decline, except those of phospholipids with side chain of 36:1. Furthermore, the levels of lyso-phospholipids and sphingolipids, including ceramide and its derivatives, were dramatically elevated in the present DN rat model. Our findings, which provide a comprehensive lipidome of the kidney cortex in rats with DN, are expected to be useful for the identification of pathologically relevant lipid species in DN. Furthermore, the results represent novel insights into the mechanistic basis of DN.",
        "keywords": [
            "diabetic nephropathy",
            "glomerular filtration barrier",
            "lipidomics",
            "lipotoxicity",
            "sphingolipids"
        ],
        "authors": [
            {
                "name": "Biyu Hou",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Ping He",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Peng Ma",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Xinyu Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Chunyang Xu",
                "org": "Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China."
            },
            {
                "name": "Sin Man Lam",
                "org": "Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China."
            },
            {
                "name": "Guanghou Shui",
                "org": "Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China."
            },
            {
                "name": "Xiuying Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Li Zhang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Guifen Qiang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College, Beijing Key Laboratory of Drug Target, Screening Research, Chinese Academy of Medical Sciences, Beijing, China."
            }
        ],
        "venue": "Frontiers in endocrinology",
        "year": 2020
    },
    "oyTez3EE": {
        "id": "oyTez3EE",
        "title": "Anti-inflammatory activity of methyl salicylate glycosides isolated from Gaultheria yunnanensis (Franch.) Rehder.",
        "abstract": "Gaultheria yunnanensis (Franch.) Rehder is a kind of traditional Chinese herbal medicine used for the treatments of rheumatoid arthritis, swelling and pain. Two methyl salicylate glycosides, namely methyl benzoate-2-O-β-D-xylopyranosyl(1-6)-O-β-D-gluco-pyranoside (J12122) and methyl benzoate-2-O-β-D-xylopyranosyl(1-2)[O-β-D-xylopyranosyl(1-6)]-O-β-D-glucopyranoside (J12123), are natural salicylic derivatives isolated from Gaultheria yunnanensis. In this study, we investigated the anti-inflammatory activity of J12122 and J12123 on LPS-induced RAW264.7 macrophage cells by measuring the production of pro-inflammatory cytokines, accumulation of nitric oxide (NO), and level of reactive oxygen species (ROS). The results showed that both methyl salicylate glycosides dose-dependently inhibited the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, respectively. Consistent with these observations, J12122 and J12123 significantly suppressed the accumulation of NO, with an inhibitory rate of 56.20% and 51.72% at 3.0 μg/mL concentration, respectively. Furthermore, the two methyl salicylate glycosides reduced the level of ROS induced by LPS. These results showed that the isolated compounds possess anti-inflammatory properties through inhibition the production pro-inflammatory cytokines, NO, and ROS.",
        "keywords": [
            "anti-inflammation",
            "gaultheria plant",
            "inflammatory cytokines",
            "methyl salicylicate glycoside"
        ],
        "authors": [
            {
                "name": "Dan Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Rui Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lan Sun",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Chao Huang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Chao Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dong-Ming Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tian-Tai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2011
    },
    "rv7dI9he": {
        "id": "rv7dI9he",
        "title": "A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages.",
        "abstract": "Methyl salicylate 2-O-β-D-lactoside (DL0309), is a molecule chemically related to salicylic acid that is isolated from Gaultheria yunnanensis (FRANCH.) REHDER (G. yunnanensis). G. yunnanensis, a traditional Chinese herbal medicine, is widely used for treating rheumatoid arthritis, swelling, pain, trauma, and chronic tracheitis. In the present study, we explored the mechanism whereby DL0309 exerts anti-inflammatory effects, using the model of lipopolysaccharide (LPS)-treated RAW264.7 cells. We examined the effects of DL0309 on LPS-induced nuclear factor-kappaB (NF-κB) activity by Western blot analysis, cell imaging analysis and an electrophoretic mobility shift assay (EMSA). Production of pro-inflammatory cytokines was also measured. Our observations indicate that DL0309 suppressed production of nitric oxide (NO), reactive oxygen species (ROS) and the pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), in a concentration-dependent manner. The phosphorylation of IKK-β and degradation of IκB-α by LPS were both inhibited by DL0309 in the cytoplasm. The increased protein level of NF-κB by LPS in the nucleus was also reduced by DL0309. Consistent with these results, we found that DL0309 prevents the nuclear translocation and DNA binding activity of NF-κB. Finally, our results demonstrate that DL0309 exerts anti-inflammatory effects, by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB signaling pathway in LPS-treated macrophage cells. Therefore, DL0309 may have therapeutic potential for treating inflammatory diseases by regulating the NF-κB pathway and pro-inflammatory cytokine production.",
        "keywords": [
            "anti-inflammation",
            "methyl salicylate 2-o-β-d-lactoside",
            "tnf-α",
            "nf-κb signaling pathway",
            "gaultheria yunnanensis"
        ],
        "authors": [
            {
                "name": "Tiantai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lan Sun",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Rui Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dan Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xi Lan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Chao Huang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Wenyu Xin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Chao Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dongming Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Molecular pharmaceutics",
        "year": 2012
    },
    "VfqgvbCS": {
        "id": "VfqgvbCS",
        "title": "The Patch-Clamp Array Technologies and their Application in Pharmaceutical Screening",
        "abstract": "Ion channels are an important class of therapeutic drug targets.Since the patch-clamp method was first described nearly 30 years ago,it has been the best way to study ion-channel function and related drugs.But the low throughput has always been the main embarrassment for voltage clamp applying to pharmaceutical screening.Effective screening of large compound libraries in ion channel drug discovery requires the development of new electrophysiological techniques with substantially increased throughputs compared to the conventional patch clamp technique.Recently,a number of researchers have started to automate patch clamping by either automating conventional micropipette-based patch clamping or developing planar microelectrode arrays.This article discusses the technical details,advantages,and disadvantages of each approach and technique and reviews the brief history of this method used to pharmaceutical screening.",
        "keywords": [
            "drug screening",
            "planar microelectrode array",
            "patch-clamp array"
        ],
        "authors": [
            {
                "name": "GAO Feng",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Letters in Biotechnology",
        "year": 2005
    },
    "alxg0SkO": {
        "id": "alxg0SkO",
        "title": "Cloning and expression of human lectin-like oxidized low density lipoprotein receptor-1 in Pichia pastoris.",
        "abstract": "Lectin-like oxidatively-modified LDL receptor-1 (LOX-1) is a major receptor for oxidized low-density lipoprotein (oxLDL) in aortic endothelial cells. Human LOX-1 (hLOX-1) gene (cDNA) was cloned from the monocytic leukemic cell line THP-1 and expressed in Pichia pastoris. The recombinant protein (rhLOX-1) was purified by his-tag affinity chromatography. Preliminary identification was performed by Western blot analysis and a ligand-receptor binding assay showed that the protein had specific oxLDL-binding activity.",
        "keywords": [
            "heterologous expression",
            "LOX-1",
            "Pichia pastoris",
            "recombinant protein"
        ],
        "authors": [
            {
                "name": "Zhentai Huang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Tiantai Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jinling Yang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Ping Zhu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Kedi Cheng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "BIOTECHNOLOGY LETTERS",
        "year": 2005
    },
    "QQRkKgEd": {
        "id": "QQRkKgEd",
        "title": "Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2",
        "abstract": "Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy (DPN). Antioxidant strategies have been most widely explored; nevertheless, whether antioxidants alone prevent DPN still remains inconclusive. In the present study, we established an  DPN cell model for drug screening using Schwann RSC96 cells under high glucose (HG) stimulation, and we found that salvianolic acid A (SalA) mitigated HG-induced injury evidenced by cell viability and myelination. Mechanistically, SalA exhibited strong antioxidative effects by inhibiting 1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing reactive oxygen species (ROS), malondialdehyde (MDA), and oxidized glutathione (GSSG) content, as well as upregulating antioxidative enzyme mRNA expression. In addition, SalA significantly extenuated neuroinflammation with downregulated inflammatory factor mRNA expression. Furthermore, SalA improved the mitochondrial function of HG-injured Schwann cells by scavenging mitochondrial ROS, decreasing mitochondrial membrane potential (MMP), and enhancing ATP production, as well as upregulating oxidative phosphorylation gene expression. More importantly, we identified nuclear factor-E2-related factor 2 (Nrf2) as the upstream regulator which mediated protective effects of SalA on DPN. SalA directly bound to the Kelch domain of Kelch-like ECH-associated protein 1 (Keap1) and thus disrupted the interaction of Nrf2 and Keap1 predicted by LibDock of Discovery Studio. Additionally, SalA significantly inhibited Nrf2 promoter activity and downregulated Nrf2 mRNA expression but without affecting Nrf2 protein expression. Interestingly, SalA upregulated the nuclear Nrf2 expression and promoted Nrf2 nuclear translocation by high content screening assay, which was confirmed to be involved in its antiglucotoxicity effect by the knockdown of Nrf2 in RSC96 cells. In KK-Ay mice, we demonstrated that SalA could effectively improve the abnormal glucose and lipid metabolism and significantly protect against DPN by increasing the mechanical withdrawal threshold and sciatic nerve conduction velocity and restoring the ultrastructural impairment of the injured sciatic nerve induced by diabetes. Hence, SalA protected against DPN by antioxidative stress, attenuating neuroinflammation, and improving mitochondrial function via Nrf2. SalA may be prospective therapeutics for treating DPN.",
        "keywords": "",
        "authors": [
            {
                "name": "Chunyang Xu",
                "org": "Harbin University of Commerce"
            },
            {
                "name": "Biyu Hou",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Ping He",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Peng Ma",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Xinyu Yang",
                "org": "College of Pharmacy, Guangdong Medical University, Dongguan 523808, China"
            },
            {
                "name": "Xiuying Yang",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Li Zhang",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Guifen Qiang",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Wenlan Li",
                "org": "College of Pharmacy, Harbin University of Commerce, Harbin 150076, China"
            },
            {
                "name": "Guanhua Du",
                "org": "Peking Union Medical College"
            }
        ],
        "venue": "Oxidative Medicine and Cellular Longevity",
        "year": 2020
    },
    "pjKqqW9c": {
        "id": "pjKqqW9c",
        "title": "[Research progress of urotensin Ⅱ and urotensin Ⅱ receptor].",
        "abstract": "Urotensin  II (UII) is the most potent vasoconstrictor among the identified vasoactive peptides. UII and its receptor (UT), which play varies of physiological roles, are widely expressed in central nerve system and peripheral organs. The change on the expressional level of UII/UT system has been proved to be closely correlated with pathological conditions. Therefore, UII/UT system was considered to be a potential target for treating many diseases. This review article is devoted to the latest research progress of UII/UT system in several aspects including ligand and receptor distribution, physiological activity, characteristics under pathological conditions and antagonist classification.",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Zhou",
                "org": ""
            },
            {
                "name": "Li Li",
                "org": ""
            },
            {
                "name": "Xu Liu",
                "org": ""
            },
            {
                "name": "Guan-hua Du",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2016
    },
    "oEcEDvky": {
        "id": "oEcEDvky",
        "title": "Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding.",
        "abstract": "Our previous work has shown that tanshinone IIA (Tan IIA) is a DNA minor groove binder instead of an intercalator as previously thought. In this study, we have further demonstrated that the molecular antitumor pharmacology of Tan IIA is dependent on its groove-binding capability. First, we investigated the structure damage to duplex DNA upon Tan IIA binding using circular dichroism spectra. Subsequently, we performed western blot, flow cytometry analysis, chromatin immunoprecipitation, and quantitative real-time PCR to illustrate the RNAPII degradation, phosphorylation, and distribution along the transcribed gene in H22 cells exposed to Tan IIA. In addition, p53 activation and apoptosis induction in both cultured H22 cells and in mice bearing the ascitic-type H22 were measured following Tan IIA treatment. It was revealed that Tan IIA decreases the level of RNAPII by altering DNA structure. At the low dose range (0.2-4 microM) of Tan IIA exposure, the DNA structure damage results in the inhibition of RNAPII binding to DNA and the initiation of RNAPII phosphorylation, while higher concentrations of Tan IIA (4-20 microM) cause complete phosphorylation and degradation of RNAPII followed by p53 activation and apoptosis. A similar apoptosis induction by RNAPII was observed in animals. Apoptosis of tumor cells from ascitic fluid was not detected until RNAPII levels were downregulated by Tan IIA, which requires 40 mg/kg body weight of Tan IIA. It was concluded that DNA-conformational-damage-dependent RNAPII response upon groove binding is the molecular basis of the antitumor property of Tan IIA, in vivo and in vitro.",
        "keywords": [
            "apoptosis",
            "dna minor groove binder",
            "rna polymerase ii",
            "tanshinone iia",
            "circular dichroism",
            "body weight",
            "chromatin immunoprecipitation",
            "dna structure",
            "flow cytometry",
            "phytochemicals",
            "cytotoxicity",
            "in vitro",
            "pharmacology"
        ],
        "authors": [
            {
                "name": "Zhichao Zhang",
                "org": ""
            },
            {
                "name": "Jin Gao",
                "org": "School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Yuanyuan Wang",
                "org": "Genetic Engineering Division, Xinao Research Institute, Langfang, PR China"
            },
            {
                "name": "Ting Song",
                "org": "State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China"
            },
            {
                "name": "Jing Zhang",
                "org": "School of Environmental and Biological Science and Technology, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Guiye Wu",
                "org": "State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, PR China"
            },
            {
                "name": "Tiantai Zhang",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": "National Center for Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            }
        ],
        "venue": "Biochemical pharmacology",
        "year": 2009
    },
    "Kjf3MnDS": {
        "id": "Kjf3MnDS",
        "title": "Effect of pinocembrin on brain mitochondrial respiratory function",
        "abstract": "There are growing evidences that pinocembrin has better neuroprotective effect. In the present study, the effect of pinocembrin on mitochondrial respiratory function was evaluated in global brain ischemia/ reperfusion (4-vessel occlusion, 4-VO) rats. The results showed that pinocembrin improved the respiratory activity of 4-VO brain mitochondria, through increasing ADP/O, state 3 respiration state (V3), respiration control rate index (RCI) and oxidative phosphorylation rate (OPR). And then, the effect of pinocembrin on brain mitochondria was verified in vitro. The results showed that pinocembrin increased ADP/O, state 3 respiration state, respiration control rate index, oxidative phosphorylation rate in NADH/FADH2 dependent respiratory chain and decreased state 4 respiration state (V4) in NADH dependent respiratory chain. Pinocembrin improved ATP content in brain mitochondria in vitro and in SH-SY5Y cells.",
        "keywords": [
            "ADP/O",
            "ATP",
            "Global brain ischemia",
            "Mitochondria",
            "Pinocembrin",
            "SH-SY5Y"
        ],
        "authors": [
            {
                "name": "Li-Li Shi",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Gui-Fen Qiang",
                "org": "Aerospace Central Hospital(Aerospace Central Hospital),Beijing,China"
            },
            {
                "name": "Mei Gao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Heng-Ai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Bai-Nian Chen",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiao-Yan Yu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Zhao-Hong Xuan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Qiao-Yun Wang",
                "org": "College of Pharmacy of BZMC(College of Pharmacy of BZMC),,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2011
    },
    "3wj8hsB0": {
        "id": "3wj8hsB0",
        "title": "Determination of salvianolic acid C in rat plasma using liquid chromatography–mass spectrometry and its application to pharmacokinetic study",
        "abstract": "A sensitive and reliable LC-ESI-MS method for the determination of salvianolic acid C in rat plasma has been developed and validated. Plasma samples were prepared by liquid-liquid extraction with ethyl acetate and separated on a Zorbax SB-C-18 column (3.5 mu m, 2.1x100mm) at a flow rate of 0.3mL/min using acetonitrile-water as mobile phase. The detection was carried out by a single quadrupole mass spectrometer with electrospray ionization source and selected ion monitoring mode. Linearity was obtained for salvianolic acid C ranging from 5 to 1000ng/mL. The intra- and inter-day precisions (RSD, %) didn't exceed 9.96%, and the accuracy (RE, %) were all within +/- 3.64%. The average recoveries of the analyte and internal standard were >89.13%. Salvianolic acid C was proved to be stable during all sample storage, preparation and analytic procedures. The validated method was successfully applied to pharmacokinetic study after oral and intravenous administration of salvianolic acid C to rats. The absolute oral bioavailability of salvianolic acid C was 0.29 +/- 0.05%. This method was further applied to simultaneous determination of salvianolic acid A, salvianolic acid B and salvianolic acid C in rat plasma and showed good practicability. Copyright (c) 2015 John Wiley & Sons, Ltd.",
        "keywords": [
            "salvianolic acid C",
            "LC-MS",
            "pharmacokinetics",
            "bioavailability",
            "dose proportionality"
        ],
        "authors": [
            {
                "name": "junke song",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Su, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "wen zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Su, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "jialin sun",
                "org": "Affiliated Hosp Qingdao Univ, Dept Pharm, Qingdao 266003, Peoples R China"
            },
            {
                "name": "xue zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Su, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "xiaona xu",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Su, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "li zhang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Su, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "zhangying feng",
                "org": "Hebei Med Univ, Hosp 4, Shijiazhuang 050011, Peoples R China"
            },
            {
                "name": "guanhua du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug Su, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "BIOMEDICAL CHROMATOGRAPHY",
        "year": 2015
    },
    "RSS6UsEQ": {
        "id": "RSS6UsEQ",
        "title": "Myricitrin attenuates 6-hydroxydopamine-induced mitochondrial damage and apoptosis in PC12 cells via inhibition of mitochondrial oxidation",
        "abstract": "Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DA) neurons at the substantia nigra. 6-Hydroxydopamine (6-OHDA) is a dopamine analog, which specifically to damage dopaminergic neurons. Myricitrin, a flavanoid isolated from the root bark of Myrica cerifera, has antinociceptive activity, anti-inflammatory, antioxidant, and immunomodulatory properties. In the present study, the potential protection and mechanism of myricitrin against 6-OHDA-induced damage and apoptosis in PC12 cells was studied. The results showed that myricitrin attenuated 6-OHDA-induced cell damage and mitochondrial dysfunction in a dose-dependent manner, which was correlated with decreased intracellular ATP content and mitochondrial membrane potential. Furthermore, it was found that myricitrin inhibited the apoptosis of PC12 cells induced by 6-OHDA in relation to reduction of cytochrome C release from mitochondria and inhibition of the activity of caspase-3. Finally, the antioxidation of myricitrin in PC12 cells and brain mitochondria was investigated. The results showed that myricitrin decreased the production of reactive oxygen species in PC12 cells and inhibited lipid peroxidation in rat brain mitochondria (IC50=3.19±0.34μM). Thus, myricitrin has the neuroprotective capacity to antagonize 6-OHDA-induced neurotoxicity in PC12 cells and may be useful in treating PD. © 2012 Elsevier Ltd.",
        "keywords": [
            "apoptosis",
            "lipid peroxidation",
            "mitochondria",
            "myricitrin"
        ],
        "authors": [
            {
                "name": "Yuehua Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Zhaohong Xuan",
                "org": "Shenyang Pharmaceutical University(Shenyang Pharmaceutical University),Shenyang,China"
            },
            {
                "name": "Shuo Tian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guorong He",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of Functional Foods",
        "year": 2013
    },
    "19hMtupa": {
        "id": "19hMtupa",
        "title": "Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats.",
        "abstract": "Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi, has been shown to be neuroprotective in several Parkinson's disease (PD) animal models. Since neuroinflammation has been known to play a critical role in the pathogenesis of PD, potential explanation for the neuroprotective action of anti-PD compounds involves among others reduced inflammation. Our study investigated that one of the mechanisms of protection afforded by baicalein in rotenone-induced parkinsonian rats was associated with anti-inflammatory action and explored its underlying mechanism in vivo and in vitro. The results showed that baicalein treatment improved motor impairments, attenuated brain damage, suppressed the production of proinflammatory cytokines (tumor necrosis factor α (TNF-α), and interleukin 6 (IL-6)), modulated the astrocytes and microglia activation, and blocked the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signals in rotenone-induced rats of PD. Furthermore, treatment of baicalein prominently suppressed the generation of nitric oxide (NO) and the expression of inducible NO synthase (iNOS) protein by blocking LPS-induced IκBα phosphorylation and NF-κB translocation, and downregulated the Toll-like receptor 4 (TLR4) which functions in the upstream of NF-κB signal in the activated BV2 microglia. In conclusion, our studies suggest that baicalein may be effective in the treatment of PD through anti-neuroinflammation.",
        "keywords": [
            "Baicalein",
            "MAPKs",
            "NF-κB",
            "Neuroinflammation",
            "Parkinson's disease"
        ],
        "authors": [
            {
                "name": "Xue Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Yulin Yang",
                "org": "Guangdong Pharmaceutical University, Guangzhou 510006, China."
            },
            {
                "name": "Lida Du",
                "org": "School of Biomedical Science, The Chinese University of Hong Kong, Hong Kong Special Administrative Region."
            },
            {
                "name": "Wen Zhang",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            }
        ],
        "venue": "International immunopharmacology",
        "year": 2017
    },
    "RIFr6KUy": {
        "id": "RIFr6KUy",
        "title": "Identification of active compounds and their metabolites by high-performance liquid chromatography/electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry from Xiao-xu-ming decoction (XXMD).",
        "abstract": "Xiao-xu-ming decoction (XXMD) prescription is a traditional Chinese prescription that has been widely used to treat theoplegia and the sequela of theoplegia. Modern pharmacological research has also indicated that the active fraction from XXMD is able to treat cardiovascular diseases and Alzheimer's disease. In the study reported here, high-performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry (HPLC/FTICR-MS) was developed to identify active compounds and their metabolites after oral administration of active fraction from Xiao-xu-ming decoction to rats, using parent mass list triggered data-dependent multiple-stage mass analysis at a resolving power of 100,000 in the external calibration mode. The mass accuracies obtained for full-scan MS were within 2 ppm in most cases. Fifteen constituents were identified in the active fraction from XXMD and the biological samples of rats. The fragmentation behaviors of these constituents were summarized which would be helpful for structural characterization. The profiles of the constituents in the active fraction and biological samples of rats were obtained which provided us with much information for a better understanding of the chemical basis of the pharmacologic actions of XXMD.",
        "keywords": [
            "fourier transform ion cyclotron resonance",
            "electrospray ionization",
            "mass spectrometry",
            "high performance liquid chromatography"
        ],
        "authors": [
            {
                "name": "Yilin Wang",
                "org": ""
            },
            {
                "name": "Chunguang Ding",
                "org": ""
            },
            {
                "name": "Kehe Du",
                "org": ""
            },
            {
                "name": "Yao Xiao",
                "org": ""
            },
            {
                "name": "Caisheng Wu",
                "org": ""
            },
            {
                "name": "Jinlan Zhang",
                "org": ""
            },
            {
                "name": "Hailin Qin",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Rapid communications in mass spectrometry : RCM",
        "year": 2009
    },
    "qZRtGIZL": {
        "id": "qZRtGIZL",
        "title": "Effect of coptisine on the function of isolated thoracic aorta of L-NAME induced hypertensive rats",
        "abstract": "Aim: To investigate the effect of coptisine on the vascular activity of hypertensive rats treated by L-NAME. Methods: Coptisine was orally administered for 6 weeks after the hypertension was established by L-NAME treatment in rats. Then the rat aorta was harvested to evaluate its vasoactivity induced by various stimulus. Results: Chronic inhibition of nitric oxide synthesis by L-NAME led to sustained elevation of blood pressure of rats, as well as vascular dysfunction. Coptisine failed to block the increase of systolic blood pressure in the L-NAME treated rats without affecting the vasocontrictory profile and the endothelium-dependent vasorelaxation. However, the contraction induced by intracellular Ca2+ released by the sarcoplasmic reticulum was enhanced by coptisine treatment, whereas the contractile response to CaCl 2 in Ca2+-free medium was decreased due to coptisine therapy. Conclusions These results indicate that the hypertension induced by L-NAME is associated with NO deficiency and coptisine might interfere with the IP3-Ca2+ pathway in rat aortas. Coptisine shows no antihypertensive action on the L-NAME induced hypertensive rats.",
        "keywords": [
            "Aorta",
            "Coptisine",
            "Hypertension",
            "L-NAME",
            "Nitric oxide",
            "Vascular function"
        ],
        "authors": [
            {
                "name": "CHEN Bai-nian",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "YU Xiao-yan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "SUN Jia-lin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "SHI Li-li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "ZHANG Heng-ai",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Jing Guo",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "FANG Lian-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "QIN Hai-lin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2011
    },
    "ap4gnYyV": {
        "id": "ap4gnYyV",
        "title": "Puerarin attenuates the endothelial-mesenchymal transition induced by oxidative stress in human coronary artery endothelial cells through PI3K/AKT pathway.",
        "abstract": "Endothelial-mesenchymal transition (EndMT) is a process in which endothelial cells lose their specific morphology/markers and undergo a dramatic remodeling of the cytoskeleton. It has been implicated in the progression of cardiovascular diseases such as cardiac fibrosis and cardiac dysfunction. Recent study indicated that puerarin could inhibit EndMT against cardiac fibrosis. However, the precise role of puerarin in EndMT and the underlying molecular mechanisms remain unclear. EndMT was induced by HO (150 μM) in human coronary artery endothelial cells (HCAECs). HCAECs were exposed to HO for six days with or without puerarin pretreated 2 h. The protein changes of EndMT markers (CD31, VE-cadherin, FSP1 and α-SMA) in HCAECs were detected. The levels of phosphoinositide-3-kinase (PI3K) and protein kinase B (AKT) proteins were analyzed by Western Blot. Wound healing and transwell assay were carried out to examine cell chemotaxis. Puerarin mitigated HO-induced EndMT as indicated by alleviating the reduced expression of CD31 and VE-cadherin and inhibiting the upregulation of α-SMA and FSP1. Furthermore, the mechanisms study showed that puerarin activated the PI3K/AKT pathway by inhibiting reactive oxygen species and further attenuated EndMT. On the other hand, PI3K inhibitor LY294002 reversed this effect imposed by puerarin. Puerarin alleviated the migration of mesenchymal-like cells through reducing MMPs protein expression. These results implicated that puerarin exhibited cytoprotective effects against HO-induced EndMT in HCAECs through alleviating oxidative stress, activating the PI3K/AKT pathway and limiting cell migration.",
        "keywords": [
            "Endothelial-mesenchymal transition",
            "HCAECs",
            "Oxidative stress",
            "PI3K/AKT",
            "Puerarin"
        ],
        "authors": [
            {
                "name": "Xuguang Li",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Shuchan Sun",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Di Chen",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Tianyi Yuan",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Yucai Chen",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Danshu Wang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Lianhua Fang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: fanglh@imm.ac.cn."
            },
            {
                "name": "Yang Lu",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2020
    },
    "KcXZxyRZ": {
        "id": "KcXZxyRZ",
        "title": "Potential quality evaluation approach for the absolute growth years' wild and transplanted Astragali Radix based on anti-heart failure efficacy.",
        "abstract": "The quality of Astragali Radix (AR) was closely related to the growth period. However, the current commodity grades of AR were only divided by diameter but not directly related to the growth period, which leads to the contradiction between the grade standard and the quality evaluation index. Therefore, solving this problem will be the key for the quality evaluation of AR. The present study established a potential quality evaluation approach for the absolute growth years' wild Astragali Radix (WAR) and transplanted Astragali Radix (TAR) based on the chemical components and anti-heart failure efficacy through adopting a bare-handed sections approach to rapidly identify the growth years of WAR. In this study, the absolute growth years of WAR were obtained by identifying the growth rings of 1-6 growth years root through the methods. The contents of flavonoids and saponins in 2-6 growth years' WAR were determined by HPLC-UV-ELSD. The contents of 12 chemical components and the anti-fatigue failure effects of WAR (4-year-old) and TAR were compared on rat models of heart failure induced by doxorubicin. Meanwhile, NMR-based untargeted metabolomics studies were performed to investigate the regulative effects of WAR and TAR. The result shows that the numbers of growth rings were consistent with the actual growth periods of AR. The HPLC-UV-ELSD determination indicated that the content of total flavonoids in WAR was significantly higher than that in TAR. Pharmacodynamics analysis revealed that the effects of WAR on cardiac function parameters (EF, FS and LVIDs), contents of serum CK and BNP were superior to those of TAR. 13 metabolites of heart were identified that had a higher rate of change in WAR group than TAR. Overall, a rapid identification method for the growth years of WAR was established, and the fact that WAR were significantly better than TAR in the heart failure rats was first proved in the paper. This study provided a scientific basis for establishing a novel commodity specification and grade of AR for clinical rational drug use.",
        "keywords": [
            "Anti-heart failure",
            "Astragali Radix",
            "Chemical analysis",
            "Growth rings"
        ],
        "authors": [
            {
                "name": "Ke Li",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Rui Zhang",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Shu-Ying Li",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Yue-Tao Liu",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Ai-Ping Li",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Xiao-Jie Liu",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China."
            },
            {
                "name": "Guan-Hua DU",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Xue-Mei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China; Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China. Electronic address: qinxm@sxu.edu.cn."
            }
        ],
        "venue": "Chinese journal of natural medicines",
        "year": 2020
    },
    "NHA5Er7Q": {
        "id": "NHA5Er7Q",
        "title": "DL0805 inhibits the vasoconstriction induced by angiotensin Ⅱ in a Ca~(2+)-dependent and Ca~(2+)-independent manner in the rat aorta",
        "abstract": "Objective To investigate the mechanisms of DL0805,a Rho kinase inhibitor,in the relaxation on the contraction induced by angiotensin Ⅱ(Ang Ⅱ) in the rat thoracic aorta.Methods Intracellular (i) was measured with Fura2/AM in vascular smooth muscle cell(VSMC).Protein level of Rho kinase 1(ROCK1),the phosphorylation levels of myosin phosphatase target subunit 1(MYPT1) and Akt in the rat aortic rings were detected by Western blotting.Results DL0805(1,10 μmol/L) were shown to inhibit both Ang Ⅱ(100 nmol/L)-induced Ca2+ release from internal stores and Ca2+ influx.DL0805(25、50 μmol/L) significantly attenuated the increased protein level of ROCK1,the increased phosphorylation levels of MYPT1 and Akt in the aorta stimulated by Ang Ⅱ(100 nmol/L).Conclusions DL0805 inhibits the vasoconstriction induced by Ang Ⅱ in a Ca2+-dependent and Ca2+-independent manner in the rat thoracic aorta.",
        "keywords": [
            "intracellular calcium",
            "DL0805",
            "angiotensin Ⅱ",
            "Rho kinase",
            "rat thoracic aortic rings",
            "vascular smooth muscle cell"
        ],
        "authors": [
            {
                "name": "LI Li",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "YUAN Tianyi",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "GUO Jing",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "FANG Lianhua",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "YANG Haiguang",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guanhua",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Journal of Capital Medical University",
        "year": 2013
    },
    "zZij60rt": {
        "id": "zZij60rt",
        "title": "The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation.",
        "abstract": "Influenza virus is one of the most important causes of acute respiratory disease. Viral infection and viral replication activate multiple cell signalling pathways. Apoptosis of infected cells and immune response against viral replication, which are generally considered to be protective mechanisms, are also probably mediated by viruses, which lead to severe health problems. We previously reported that 3-deoxysappanchalcone (3-DSC), a compound that is isolated from Caesalpinia sappan, exhibited in vitro anti-influenza activity. In the present study, we further identified that 3-DSC inhibited viral genomic replication and transcription only at a relatively high concentration. We then evaluated the effect of 3-DSC on the regulation of virus-induced cellular apoptosis. 3-DSC ameliorated virus-induced DNA fragmentation in a concentration-dependent manner, which tends to be a consequence of its inhibition of upstream caspase activation. 3-DSC also protected host cells against influenza-induced inflammation by suppressing CCL5 and CXCL10 secretions in endothelial cells and reducing the production of IL-6 and IL-1β in monocytes/macrophages. In conclusion, our results demonstrate that anti-influenza virus mechanisms of 3-DSC involved anti-apoptosis and anti-inflammation activities in vitro. Moreover, 3-DSC could be a promising drug candidate for influenza treatment.",
        "keywords": [
            "apoptosis",
            "leguminosae",
            "influenza",
            "3-deoxysappanchalcone",
            "caesalpinia sappan l.",
            "inflammation"
        ],
        "authors": [
            {
                "name": "Fan Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Wei-Ling Zhou",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Simon Ming-Yuen Lee",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Yi-Tao Wang",
                "org": "University of Macau(University of Macau),Taipa,Macao"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Planta medica",
        "year": 2012
    },
    "9g6uPD7a": {
        "id": "9g6uPD7a",
        "title": "Research progress in pharmacology of natural isoflavones",
        "abstract": "The natural isoflavone compounds exist widely in nature kingdom,which are the effective components from many Chinese herbal medicines.They have many kinds of pharmacological activities and have attracted a lot of attention.In this article,we collected and integrated the research literature related with isoflavones over the past decade.We more comprehensively reviewed the plant origins,and the pharmacological actions including estrogen-like effect,antitumor effect,the prevention and treatment of cardiovascular diseases,the effect on bone metabolism,neuroprotective effects and improving effect on recognition ability.This review will provide guidance for the development and utilization of natural isoflavones.",
        "keywords": [
            "natural isoflavones",
            "estrogen-like effect",
            "antitumor effects",
            "neuroprotective effects"
        ],
        "authors": [
            {
                "name": "LI Chao",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing ,China"
            },
            {
                "name": "LIU Ai-lin",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing ,China; State Key Laboratory of natural active substances and functions,Beijing ,China; Beijing Key Laboratory of Drug Target and Screening Research,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": " Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing ,China; State Key Laboratory of natural active substances and functions,Beijing ,China; Beijing Key Laboratory of Drug Target and Screening Research,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2013
    },
    "1jk4SlcK": {
        "id": "1jk4SlcK",
        "title": "Two types of crystalline of pinocembrin, their preparation and their use for manufacture of pharmaceutical compositions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "yang lv",
                "org": ""
            },
            {
                "name": "song wu",
                "org": ""
            },
            {
                "name": "ke wang",
                "org": ""
            },
            {
                "name": "ying chang",
                "org": ""
            },
            {
                "name": "zhihong yang",
                "org": ""
            },
            {
                "name": "yuanfeng tong",
                "org": ""
            },
            {
                "name": "mei gao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "S5QN3nsN": {
        "id": "S5QN3nsN",
        "title": "Chemical constituents of the whole plant of Elsholtzia rugulosa.",
        "abstract": "A new lignan glycoside, 7α, 7'β-bis-(4-hydroxy-3-methoxyphenyl)-7,9':7',9-diepoxylignan-8αH,8'α-O-β-d-(2″,7'α-epoxy)-glucopyranoside, named elshrugulosain (1), has been isolated from the EtOH extract of Elsholtzia rugulosa, together with six known compounds, ( - )-bornyl (E)-3,4,5-trimethoxycinnamate, apigenin, luteolin, apigenin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucopyranoside, and luteolin-3'-glucuronate methyl ester. Their structures were characterized by spectroscopic methods and comparison with the data in the literature. On the basis of detailed 1D and 2D NMR spectral analysis, as well as X-ray crystallographic diffraction, the NMR spectroscopic data of ( - )-bornyl (E)-3,4,5-trimethoxycinnamate were revised and assigned completely.",
        "keywords": [
            "4",
            "labiatae",
            "elsholtzia rugulosa",
            "elshrugulosain",
            "lignan glycoside",
            "()-bornyl (e)-3",
            "5-trimethoxycinnamate"
        ],
        "authors": [
            {
                "name": "Bo Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "An-Jun Deng",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Jin-Qian Yu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of Asian natural products research",
        "year": 2012
    },
    "lgPrxkm3": {
        "id": "lgPrxkm3",
        "title": "Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area.",
        "abstract": "The aim of this study was to investigate the effects of pinocembrin on brain ischemia/reperfusion (I/R) injury and the potential involvement of autophagy activity changes in the penumbra area in the mechanisms of pinocembrin activity. Focal cerebral I/R model was induced by middle cerebral artery occlusion (MCAO) for 2 h followed by 24 h reperfusion. Pinocembrin was administered intravenously at different doses (1, 3, and 10 mg/kg, respectively) at the onset of reperfusion. Neurological function, brain infarction and brain swelling ratio were evaluated. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and immunohistochemical analysis (Caspase-3) were used to evaluate apoptosis in the penumbra cortex. Two key proteins of autophagy, LC3B and Beclin1, were detected by western blot. The results showed that pinocembrin-treatment could significantly reduce neurological deficit scores, infarct volume, cerebral edema and improve pathological lesion in the I/R rats. Pinocembrin-treatment could also reduce the number of TUNEL-positive and Caspase-3-positive neurons, and upregulate the expression of LC3B and Beclin1 in penumbra area. These results suggested that pinocembrin could protect the brain against I/R injury, and the possible mechanisms might be attributed to inhibition of apoptosis and reversed autophagy activity in penumbra area.",
        "keywords": [
            "autophagy"
        ],
        "authors": [
            {
                "name": "Gang Zhao",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. zhiweinuobeier@163.com."
            },
            {
                "name": "Wen Zhang",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. zhangwen9010@imm.ac.cn."
            },
            {
                "name": "Li Li",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lili@imm.ac.cn."
            },
            {
                "name": "Song Wu",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. ws@imm.ac.cn."
            },
            {
                "name": "Guanhua Du",
                "org": "Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2014
    },
    "B12Vhzfx": {
        "id": "B12Vhzfx",
        "title": "Aquaporins: a potential target for drug discovery",
        "abstract": "Aquaporins(AQPs) are a family of small hydrophobic,integral membrane proteins,with thirteen aquaporins identified up to date.AQPs have recently been implicated in mammalian physiological and pathophysiologic mechanisms,such as urinary concentrating function,brain edema formation,regulation of intraocular pressure,fat metabolism,exocrine glandular fluid secretion,as well as tumor angiogenesis.Interfering with the expression of AQPs will undoubtedly have therapeutic applications.Although AQP modulators remain to be discovered,it is a potential drug target and the method of high-throughput screening will promote the proceeding for finding new drug based on AQPs.",
        "keywords": [
            "aquaporin",
            "metalloprotease",
            "water transport",
            "ADAMTS1",
            "drug discovery",
            "angiogenesis"
        ],
        "authors": [
            {
                "name": "MU Xin",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2008
    },
    "9J93nVlI": {
        "id": "9J93nVlI",
        "title": "Establishment of a Mouse Model of Systemic Lupus Erythematosus induced by Campylobacter jejuni and Complete Freund's Adjuvant",
        "abstract": "Objective To establish a mouse model of induce systemic lupus erythematosus.Methods The model of systemic lupus erythematosus was induced by Campylobacter Jejuni and complete Freund's adjuvant.The level of lymphocyte transformation index,dsDNA,matrix metalloproteinases-9(MMP9),and tumor necrosis factor-α(TNF-α) were measured.Results The body weight of model mice was significantly decreased.The values of lymphocyte transformation index,dsDNA,MMP-9,TNF-α were higher than those of the control group.Conclusion The mouse model developed in this study has some characteristics of SLE,and may serve further experimental studies of this entity.",
        "keywords": [
            "Mouse model",
            "Campylobacter jejuni",
            "complete Freund's adjuvant",
            "Systemic lupus erythematosus"
        ],
        "authors": [
            {
                "name": "YANG Xiu-min",
                "org": "Department of Dermatology,Capital Medical University Affiliated Tongren Hospital,Beijing ,China"
            },
            {
                "name": "ZHOU Ning",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHANG Hai-xia",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "REN De-cheng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Acta Laboratorium Animalis Scientia Sinica",
        "year": 2009
    },
    "xCbL9xyH": {
        "id": "xCbL9xyH",
        "title": "Active Constituents in Danshen and Their Pharmacological Actions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ailin liu",
                "org": "peking union medical college"
            },
            {
                "name": "yitao wang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "xiuying yang",
                "org": "peking union medical college"
            },
            {
                "name": "juntian zhang",
                "org": "peking union medical college"
            },
            {
                "name": "minke tang",
                "org": "peking union medical college"
            },
            {
                "name": "ji chen",
                "org": "peking union medical college"
            },
            {
                "name": "yonghong chen",
                "org": "peking union medical college"
            },
            {
                "name": "zhiwei qu",
                "org": "peking union medical college"
            },
            {
                "name": "jie wang",
                "org": "peking union medical college"
            },
            {
                "name": "xiaoying wang",
                "org": "peking union medical college"
            },
            {
                "name": "yan sun",
                "org": "peking union medical college"
            },
            {
                "name": "ping chen",
                "org": "peking union medical college"
            },
            {
                "name": "chuan li",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "d7R1M216": {
        "id": "d7R1M216",
        "title": "Effects of Danshen on the Cardiovascular System",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoming zhu",
                "org": "peking union medical college"
            },
            {
                "name": "lianhua fang",
                "org": "peking union medical college"
            },
            {
                "name": "guanhua du",
                "org": "peking union medical college"
            },
            {
                "name": "ran zhang",
                "org": "peking union medical college"
            },
            {
                "name": "dongxia wang",
                "org": "peking union medical college"
            },
            {
                "name": "jinglan xu",
                "org": "peking union medical college"
            },
            {
                "name": "xiaoying wang",
                "org": "peking union medical college"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "I84zJgG2": {
        "id": "I84zJgG2",
        "title": "Effects of Recombinant Human Ciliary Neurotrophic Factor on Intestine Function in Diabetes Mellitus Rat Model",
        "abstract": "OBJECTIVE To investigate the activity of the recombinant human ciliary neurotrophic factor(rhCNTF)on gastrointestinal neurosis in diabetic rats.METHODS Diabetic rat models were built by STZ,and rats were administered with rhCNTF for 85 d after the administration of streptozocin(STZ).The dose of RhCNTF were 0.1,0.3,0.9 mg·kg~(-1).Effects of rhCNTF on blood glucose,slow wave in stomach intestine,S100 in intestine,peristalsis,sensitivity to Ach and artropine in intestine were determined.RESULTS The effect of rhCNTF on blood glucose was not obtained compared with the vehicle group,and so did the contract character of jejunum treated with Ach and Atropine.The frequency of slow wave of jejunum was improved.The drive functions of the intestine were augmented,and so did the contents of S100 in intestine.CONCLUSION The function of intestine in diabetic rat can be improved by rhCNTF administering,and the important mechanism is the nerve protective effects of rhCNTF.",
        "keywords": [
            "Diabetes mellitus",
            "Intestine function",
            "Neuropathy",
            "Recombinant human ciliary neurotrophic factor"
        ],
        "authors": [
            {
                "name": "LIU Qing-shan",
                "org": "National Research Center for Chinese Minority Nationality Medicine,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "LI Shao-jing",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "CUI Jian",
                "org": "National Research Center for Chinese Minority Nationality Medicine,Central University for Nationalities,Beijing ,China"
            },
            {
                "name": "ZHU Xiao-ming",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "TAN Chu-bing",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2008
    },
    "32cqkAeG": {
        "id": "32cqkAeG",
        "title": "Arjunic acid, a strong free radical scavenger from Terminalia arjuna.",
        "abstract": "This study was designed to investigate the antioxidant and free radical scavenging capacities of arjunic acid, an aglycone obtained from the fruit of medicine Terminalia Fruit. Liver microsomes, mitochondria, and red blood cells (RBCs) were prepared from Wistar rats. The antioxidant capacity was determined by the inhibitory effect on lipid peroxidation, hydrogen peroxide induced RBCs hemolysis, and RBCs autoxidative hemolysis. The free radical scavenging activity was tested by DPPH method and 2',7'-dichlorodihydrofluoresc in diacetate (DCFH2-DA) assay. Ascorbic acid was chosen as the positive controls. Results showed that arjunic acid was a strong antioxidant and a free radical scavenger, more potent than ascorbic acid, in microsomes lipid peroxidation, DPPH, hydrogen peroxide induced RBCs hemolysis, and DCFH2-DA assay (p < 0.05). However, no significant difference was observed in the RBCs autoxidative hemolysis assay (p > 0.05).",
        "keywords": [
            "arjunic acid",
            "antioxidative",
            "lipid peroxidation",
            "hemolysis",
            "reactive oxygen species"
        ],
        "authors": [
            {
                "name": "Fang-Yun Sun",
                "org": "Tibet Nationalities Inst, Xianyang 712082, Peoples R China"
            },
            {
                "name": "Xiu-Ping Chen",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Jin-Hua Wang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Su-Rong Yang",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China"
            }
        ],
        "venue": "AMERICAN JOURNAL OF CHINESE MEDICINE",
        "year": 2008
    },
    "AstfBhap": {
        "id": "AstfBhap",
        "title": "METHOD FOR RESOLUTION OF A MIXTURE OF PINOCEMBRIN OPTICAL ISOMERS, ESPECIALLY A PINOCEMBRIN RACEMATE",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "song wu",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "yue yuan",
                "org": ""
            },
            {
                "name": "qingyun yang",
                "org": ""
            },
            {
                "name": "mei gao",
                "org": ""
            },
            {
                "name": "yan qi",
                "org": ""
            },
            {
                "name": "yuanfeng tong",
                "org": ""
            },
            {
                "name": "yuehua wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "68o4p5NG": {
        "id": "68o4p5NG",
        "title": "Ganoderic acid A protects neural cells against NO stress injury in vitro via stimulating β adrenergic receptors.",
        "abstract": "Excessive nitric oxide (NO) causes extensive damage to the nervous system, and the adrenergic system is disordered in many neuropsychiatric diseases. However, the role of the adrenergic system in protection of the nervous system against sodium nitroprusside (SNP) injury remains unclear. In this study, we investigated the effect of ganoderic acid A (GA A) against SNP injury in neural cells and the role of adrenergic receptors in GA A neuroprotection. We found that SNP (0.125-2 mM) dose-dependently decreased the viability of both SH-SY5Y and PC12 cells and markedly increased NO contents. Pretreatment with GA A (10 μM) significantly attenuated SNP-induced cytotoxicity and NO increase in SH-SY5Y cells, but not in PC12 cells. Furthermore, pretreatment with GA A caused significantly higher adrenaline content in SH-SY5Y cells than in PC12 cells. In order to elucidate the mechanism of GA A-protecting SH-SY5Y cells, we added adrenaline, phentolamine, metoprolol, or ICI 118551 1 h before GA A was added to the culture medium. We found that addition of adrenaline (10 μM) significantly improved GA A protection in PC12 cells. The addition of β1-adrenergic receptor antagonist metoprolol (10 μM) or β2-adrenergic receptor antagonist ICI 118551 (0.1 μM) blocked the protective effect of GA A, whereas the addition of α-adrenergic receptor antagonist phentolamine (0.1 μM) did not affect GA A protection in SH-SY5Y cells. These results suggest that β-adrenergic receptors play an important role in the protection of GA A in SH-SY5Y cells against SNP injuries, and excessive adrenaline system activation caused great damage to the nervous system.",
        "keywords": [
            "ICI 118551",
            "PC12 cells",
            "SH-SY5Y cells",
            "adrenaline",
            "ganoderic acid A",
            "metoprolol",
            "norepinephrine",
            "phentolamine",
            "sodium nitroprusside (SNP)",
            "β-adrenergic receptors"
        ],
        "authors": [
            {
                "name": "Zi-Ru Yu",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Wei-Hua Jia",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Chao Liu",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Hong-Qing Wang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Hai-Guang Yang",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Guo-Rong He",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Ruo-Yun Chen",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "Acta pharmacologica Sinica",
        "year": 2020
    },
    "RMMp4gVJ": {
        "id": "RMMp4gVJ",
        "title": "Antioxidative Effect of Fractions from Polygala caudata Rehd.et Wils.in vitro",
        "abstract": "Twelve fractions were isolated from the roots of Polygala caudata Rehd.et Wils..The scavenging activity to DPPH,superoxide anions and hydroxy radical,and reducing effect on Fe~3+ in vitro were studied.All fractions exhibited antioxidative effect in vitro and the antioxidative effect of n-butanol fraction of ethanol extract was superior to those of other fractions.It was suggested that traditional application of Polygala caudata Rehd.et Wils.in China may be related to its antioxidative activity.",
        "keywords": [
            "free radical",
            "antioxidant",
            "Polygala caudata Rehd.et Wils."
        ],
        "authors": [
            {
                "name": "HUANG Feng",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LIN Li-lin",
                "org": "Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "XIAO Pei-gen",
                "org": "Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2006
    },
    "kxgrJSzy": {
        "id": "kxgrJSzy",
        "title": "Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulation.",
        "abstract": "In this study two genistein derivatives (G1 and G2) are reported as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), and differences in the inhibition of AChE are described. Although they differ in structure by a single methyl group, the inhibitory effect of G1 (IC50=264 nmol/L) on AChE was 80 times stronger than that of G2 (IC50=21,210 nmol/L). Enzyme-kinetic analysis, molecular docking and molecular dynamics (MD) simulations were conducted to better understand the molecular basis for this difference. The results obtained by kinetic analysis demonstrated that G1 can interact with both the catalytic active site and peripheral anionic site of AChE. The predicted binding free energies of two complexes calculated by the molecular mechanics/generalized born surface area (MM/GBSA) method were consistent with the experimental data. The analysis of the individual energy terms suggested that a difference between the net electrostatic contributions (ΔE ele+ΔG GB) was responsible for the binding affinities of these two inhibitors. Additionally, analysis of the molecular mechanics and MM/GBSA free energy decomposition revealed that the difference between G1 and G2 originated from interactions with Tyr124, Glu292, Val294 and Phe338 of AChE. In conclusion, the results reveal significant differences at the molecular level in the mechanism of inhibition of AChE by these structurally related compounds.",
        "keywords": [
            "ACh",
            " acetylcholine",
            "AChE",
            " acetylcholinesterase",
            "AChEIs",
            " acetylcholinesterase inhibitors",
            "AD",
            " Alzheimer׳s disease",
            "Acetylcholinesterase (AChE)",
            "BuChE",
            " butyrylcholinesterase",
            "BuSCh",
            " S-butyrylthiocholine chloride",
            "CAS",
            " catalytic active site",
            "DTNB",
            " 5",
            "5′-dithiobis-(2-nitrobenzoic acid)",
            "G1",
            " 3-(4-methoxyphenyl)-7-(2-(piperidin-1-yl)ethoxy)-4H-chromen-4-one",
            "G2",
            " (S)-3-(4-methoxyphenyl)-7-(2-(2-methylpiperidin-1-yl)ethoxy)-4H-chromen-4-one",
            "GAFF",
            " generalized AMBER force field",
            "Genistein derivatives",
            "Kinetics analysis",
            "MD",
            " molecular dynamics",
            "MM/GBSA",
            "MM/GBSA",
            " molecular mechanics/generalized born surface area",
            "Molecular docking",
            "Molecular dynamics simulation",
            "PAS",
            " peripheral anionic site",
            "PDB",
            " protein data bank",
            "PME",
            " particle mesh Ewald",
            "RMSD",
            " root-mean-square deviation",
            "S-ACh",
            " acetylthiocholine iodide",
            "SASA",
            " solvent accessible surface area",
            "iso-OMPA",
            " tetraisopropyl pyrophosphoramide",
            "ΔEMM",
            " gas-phase interaction energy between receptor and ligand",
            "ΔEele",
            " electrostatic energy contribution",
            "ΔEvdw",
            " van der Waals energy contribution",
            "ΔGGB",
            " polar desolvation energy term",
            "ΔGSA",
            " nonpolar desolvation energy term",
            "ΔGexp",
            " experimental binding free energy",
            "ΔGpred",
            " total binding free energy",
            "ΔS",
            " conformational entropy contribution"
        ],
        "authors": [
            {
                "name": "Jiansong Fang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Ping Wu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Ranyao Yang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Li Gao",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Chao Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Dongmei Wang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Song Wu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China."
            },
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ; Beijing Key Laboratory of Drug Target Research and Drug Screening, Beijing 100050, China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China ; Beijing Key Laboratory of Drug Target Research and Drug Screening, Beijing 100050, China ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing 100050, China."
            }
        ],
        "venue": "Acta pharmaceutica Sinica. B",
        "year": 2014
    },
    "jkYEIi88": {
        "id": "jkYEIi88",
        "title": "Chemical Constituents from Terminalia chebula Retz.",
        "abstract": "Six compounds arjunglucosideⅠ(1),trans-cinnamic acid (2),triethyl ester of chebulic acid (3),arjunic acid (4),a rjungenin (5) and daucosterol (6) were isolated from the ethanol extract of the fruits of Terminalia chebula Retz..Their structures were identified by spectroscopic evidence and comparison of the data with those of the literatures.Compounds 2 and 4 were isolated from the plant for the first time.",
        "keywords": [
            "chemical constituents",
            "Terminalia chebula Retz.",
            "Combretaceae"
        ],
        "authors": [
            {
                "name": "YANG Jun-rong",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "SUN Fang-yun",
                "org": "Medical Department of Tibet National College,Xianyang ,China"
            },
            {
                "name": "LI Zhi-hong",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "QIN Hai-lin",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2008
    },
    "PD4230wv": {
        "id": "PD4230wv",
        "title": "Methyl salicylate lactoside inhibits inflammatory response on fibroblast-like synoviocytes and collagen-induced arthritis by inhibiting NF-κB activation (1056.2)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tiantai zhang",
                "org": ""
            },
            {
                "name": "wenyu xin",
                "org": ""
            },
            {
                "name": "chao huang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2014
    },
    "FqkH1Wvq": {
        "id": "FqkH1Wvq",
        "title": "NMR based metabolomic study of antifatigue effect of Astragali Radix",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhenyu li",
                "org": ""
            },
            {
                "name": "pan he",
                "org": ""
            },
            {
                "name": "haifeng sun",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "European Journal of Integrative Medicine",
        "year": 2014
    },
    "aCuQ38Vd": {
        "id": "aCuQ38Vd",
        "title": "Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice.",
        "abstract": "Methyl salicylate 2-O-β-d-lactoside (MSL), whose chemical structure is similar to that of salicylic acid, is a natural product derivative isolated from a traditional Chinese herb. The aim of this study was to investigate the therapeutic effect of MSL in mice with collagen-induced arthritis (CIA) and explore its underlying mechanism.The anti-arthritic effects of MSL were evaluated on human rheumatoid fibroblast-like synoviocytes (FLS) in vitro and CIA in mice in vivo by obtaining clinical scores, measuring hind paw thickness and inflammatory cytokine levels, radiographic evaluations and histopathological assessments.Treatment with MSL after the onset of arthritis significantly prevented the progression and development of rheumatoid arthritis (RA) in CIA mice without megascopic gastric mucosa damage. In addition, MSL inhibited the production of pro-inflammatory mediators, the phosphorylation and translocation of NF-κB, and cell proliferation induced by TNF-α in FLS. MSL non-selectively inhibited the activity of COX in vitro, but was a more potent inhibitor of COX-2 than COX-1. MSL also inhibited the phosphorylation of inhibitor of NF-κB kinase, IκBα and p65, thus blocking the nuclear translocation of NF-κB in TNF-α-stimulated FLS.MSL exerts therapeutic effects on CIA mice, suppressing the inflammatory response and joint destruction by non-selectively inhibiting the activity of COX and suppressing activation of the NF-κB signalling pathway, but without damaging the gastric mucosa. Therefore, MSL has great potential to be developed into a novel therapeutic agent for the treatment of RA.",
        "keywords": [
            "cia",
            "nf-κb signal pathway",
            "cyclooxygenase",
            "fibroblast-like synoviocytes",
            "methyl salicylate 2-o-β-d-lactoside",
            "pro-inflammatory cytokine",
            "rheumatoid arthritis"
        ],
        "authors": [
            {
                "name": "Wenyu Xin",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, China; Binzhou Medical University, Yantai, China."
            },
            {
                "name": "Chao Huang",
                "org": ""
            },
            {
                "name": "Xue Zhang",
                "org": ""
            },
            {
                "name": "Sheng Xin",
                "org": ""
            },
            {
                "name": "Yiming Zhou",
                "org": ""
            },
            {
                "name": "Xiaowei Ma",
                "org": ""
            },
            {
                "name": "Dan Zhang",
                "org": ""
            },
            {
                "name": "Yongjie Li",
                "org": ""
            },
            {
                "name": "Sibai Zhou",
                "org": ""
            },
            {
                "name": "Dongming Zhang",
                "org": ""
            },
            {
                "name": "Tiantai Zhang",
                "org": ""
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "British journal of pharmacology",
        "year": 2014
    },
    "IZbvhoIB": {
        "id": "IZbvhoIB",
        "title": "Efficacy of low‐molecular‐weight heparin on the outcomes of in vitro fertilization/intracytoplasmic sperm injection pregnancy in non‐thrombophilic women: a meta‐analysis",
        "abstract": "IntroductionThe aim of our study was to evaluate the effect of low-molecular-weight heparin on pregnancy outcomes in women without thrombophilia during in vitro fertilization/intracytoplasmic sperm injection treatment. Material and methodsWe searched Pubmed, Web of Science, Embase, Cochrane and CNKI (from inception to 2 February 2018). Our study identified randomized controlled trials or quasi-randomized controlled trials comparing low-molecular-weight heparin subcutaneous treatment with no treatment or only luteal support control. The outcomes included live birth rate, clinical pregnancy rate and miscarriage rate. ResultsFive trials, including 935 women receiving in vitro fertilization/intracytoplasmic sperm injection treatment, were included in meta-analyses. There were 458 women receiving low-molecular-weight heparin and 477 in the control group. No significant differences for live birth rate, clinical pregnancy rate and miscarriage rate were found between the low-molecular-weight heparin and control groups. Of them, four trials reported live birth rate as an outcome and the risk ratio was 1.13 (95% confidence interval 0.88-1.43, p = 0.34). All five trials reported clinical pregnancy rate as an outcome, the risk ratio was 1.08 (95% confidence interval 0.87-1.32, p = 0.47). Three trials reported miscarriage rate and the risk ratio was 0.58 (95% confidence interval 0.30-1.10, p = 0.09). In women with two or more failed in vitro fertilization/intracytoplasmic sperm injection cycles, the risk ratio of live birth rate was 1.15 and the risk ratio of clinical pregnancy rate was 1.17. In women with three or more failed in vitro fertilization/intracytoplasmic sperm injection cycles, the risk ratios of live birth rate and clinical pregnancy rate were 1.36 and 1.35, respectively. ConclusionsOur results suggested that low-molecular-weight heparin had no effect on pregnancy success rate in non-thrombophilic women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment. However, to justify the use of low-molecular-weight heparin in clinical practice, multicenter trials are still necessary.",
        "keywords": [
            "Low-molecular-weight heparin",
            "in vitro fertilization",
            "intracytoplasmic sperm injection",
            "non-thrombophilia",
            "pregnancy outcomes",
            "randomized controlled trial"
        ],
        "authors": [
            {
                "name": "Xiu‐Li Yang",
                "org": "Department of Obstetrics and Gynecology Peking University First Hospital BeijingChina"
            },
            {
                "name": "Fei Chen",
                "org": "Department of Obstetrics and Gynecology Peking University First Hospital BeijingChina"
            },
            {
                "name": "Xiu‐Ying Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia Medica of Peking Union Medical College Beijing China"
            },
            {
                "name": "Guan‐Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research Institute of Materia Medica of Peking Union Medical College Beijing China"
            },
            {
                "name": "Yang Xu",
                "org": "Department of Obstetrics and Gynecology Peking University First Hospital BeijingChina"
            }
        ],
        "venue": "Acta Obstetricia et Gynecologica Scandinavica",
        "year": 2018
    },
    "U42sNYLj": {
        "id": "U42sNYLj",
        "title": "Systems biology:a new drive for drug research and development",
        "abstract": "Systems biology is the analysis of the elements and their relationships in a system in response to genetics or environmental perturbations. Systems biology, based on bio-information and resorted to perturbation and simulation, is a new field and branch of biology, which integrates all aspects of life sciences as a whole. The theory, methods and related research outcomes of systems biology will provide new perspectives and means for discovery, research and development for both western medicine and Traditional Chinese Medicine. Systems biology will become a new drive of drug research and development.",
        "keywords": [
            "systems biology",
            "drug research and development",
            "drug discovery",
            "Traditional Chinese Medicine"
        ],
        "authors": [
            {
                "name": "TAN Chu-bing",
                "org": " Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing , China"
            },
            {
                "name": "DU Guan-hua",
                "org": " Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2006
    },
    "cotRnUUs": {
        "id": "cotRnUUs",
        "title": "Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: A 1H NMR-based metabolomics approach",
        "abstract": "",
        "keywords": [
            "biomarkers",
            "metabolomics"
        ],
        "authors": [
            {
                "name": "caichun liu",
                "org": ""
            },
            {
                "name": "yanfei wu",
                "org": ""
            },
            {
                "name": "guangming feng",
                "org": ""
            },
            {
                "name": "xiaoxia gao",
                "org": ""
            },
            {
                "name": "yuzhi zhou",
                "org": ""
            },
            {
                "name": "wenjing hou",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "junsheng tian",
                "org": ""
            }
        ],
        "venue": "Journal of Affective Disorders",
        "year": 2015
    },
    "WCCShZ5v": {
        "id": "WCCShZ5v",
        "title": "Multi-target and multi-component pattern,a superficial understanding of the action mechanism of Traditional Chinese Medicine",
        "abstract": "The study of the action mechanism of Chinese materia medica(CMM) prescriptions is a critical step in the development of CMM,and lays a foundation of the internationalization of CMM.Using modern scientific theories and techniques in combination,the multi-target and multi-component pattern has been explored and accepted as the very mechanism of CMM,and is used to guide CMM research.In this study,according to the recent progress in CMM mechanism study and the pharmaceutical development tendency both at home and abroad,the underlying CMM mechanism was considered to be the interaction of two complicated biosystems,that is,the complex material system composed of active drug ingredients and the complex biological system composed of drug targets under pathological conditions,which function interactively in disease treatment.The statistical analysis showed that the multi-target and multi-component pattern cannot give a good explanation to the action features and mechanism of CMM,especially the organic combination of multiple drug ingredients and association variation of multiple drug targets.Actually CMM functions via the interaction of the above-mentioned two systems,which may be described with active ingredient groups of CMM.",
        "keywords": [
            "effective component group",
            "TCM",
            "drug targets",
            "action mechanism"
        ],
        "authors": [
            {
                "name": "Du Guanhua",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Wang Yuehua",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Zhang Ran",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Tan Chubing",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "He Xiaoli",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Hu Juanjuan",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Zhang Li",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Chen Ruoyun",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Qin Hailin",
                "org": "Key Laboratory of Biosynthesis of Natural Products,the Ministry of Public Health,Institute of Materia Medico, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "World Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica)",
        "year": 2009
    },
    "sY3jm1Jn": {
        "id": "sY3jm1Jn",
        "title": "Prorenin and prorenin receptor:new members of renin angiotensin system",
        "abstract": "For many years,prorenin was simply considered as inactive precursor of renin.However,some findings recently implicated that prorenin had functions after all.The discovery of prorenin receptor is attracting more attention on renin and prorenin.Prorenin receptor is expressed in heart,kidney and various cells.Both of renin and prorenin are able to bind to this receptor.In heart,kidney,blood vessels and many other tissues,prorenin binding with prorenin receptor will result in series of biological effects,including angiotensin-dependent and angiotensin-independent effects.The prorenin receptor,which may be a potential drug target,is of great importance in drug discovery.This review will discuss the prorenin,prorenin receptor and their functions.",
        "keywords": [
            "prorenin",
            "prorenin receptor",
            "renin angiotensin system(RAS)",
            "renin"
        ],
        "authors": [
            {
                "name": "TIAN Shuo",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2009
    },
    "TAT8LSsw": {
        "id": "TAT8LSsw",
        "title": "A 1 H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "biyun shi",
                "org": ""
            },
            {
                "name": "junsheng tian",
                "org": ""
            },
            {
                "name": "huan xiang",
                "org": ""
            },
            {
                "name": "xiaoqing guo",
                "org": ""
            },
            {
                "name": "lizeng zhang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            }
        ],
        "venue": "Behavioural Brain Research",
        "year": 2013
    },
    "cIwmYe7I": {
        "id": "cIwmYe7I",
        "title": "Quality evaluation of low molecular weight heparin injection",
        "abstract": "Objective: To evaluate the quality status and problems of low molecular weight heparin injection and study the scientificity of the current quality standard and the test method. Methods: The statutory methods were used to test the samples. Several test methods for exploratory research were established and improved:( 1) determination of the activity of anti- FXa and anti- FIIa by micro- chromogenic substrate methods;( 2) improvement of the method to establish the calibration curve of molecular weight determination;( 3) establishment of the high performance anion exchange chromatography( HPAEC) to determine relative substances;( 4) establishment of the mutiangle laser light scatter( MALLS) method to determine the absolute molecular weight of low molecular weight heparin;( 5)quality comparison between imported products and original research plant;( 6) implementation of field researches to production enterprises. Results: There were individual samples which did not meet the standard requirements,and whose molecular weight distribution,anti- FXa and anti- F IIa activity were the major nonconforming items. Quality standards and product quality of the production enterprises had significant difference,and there was a great quality gap between the domestic low- molecular- weight heparins and the imported preparations. After the samples were degraded by nitrous acid,the separation of dermatan sulfate( DS) and oversulfated chondroitin sulfate( OSCS) was greater than 3. 0; OSCS were not detected in any samples; DS contents were less than 2. 0%. This test indicated that establishment of laser light scattering method was significant to calibrate the reference substance for the molecular weight of the low molecular weight heparin. The capability of key quality control inspection of production enterprise needed to be improved. Conclusion: Most of the domestic low molecular weight heparin injections can meet the requirements of the statutory specification. The statutory specification does not classify the low molecular weight heparin,and the standard is low. As generic drugs,domestic low molecular weight heparins have a large gap on product quality and specification,compared with foreign original research plants. The status needs to be improved urgently.",
        "keywords": [
            "quality evaluation",
            "molecular weight",
            "quality specification",
            "evaluative testing",
            "low molecular weight heparin",
            "activity of anti-FXa and anti-FIIa"
        ],
        "authors": [
            {
                "name": "LI Jing",
                "org": ""
            },
            {
                "name": "WANG Yue",
                "org": ""
            },
            {
                "name": "SONG Yu-juan",
                "org": ""
            },
            {
                "name": "FAN Hui-hong",
                "org": ""
            },
            {
                "name": "Ding Li-xia",
                "org": ""
            },
            {
                "name": "Du Guan-hua",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Pharmaceutical Analysis",
        "year": 2013
    },
    "aeUYhEXt": {
        "id": "aeUYhEXt",
        "title": "J20619 inhibits PDGF-BB-stimulated vascular smooth muscle cell proliferation and migration (1065.2)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lianhua fang",
                "org": ""
            },
            {
                "name": "jing guo",
                "org": ""
            },
            {
                "name": "li li",
                "org": ""
            },
            {
                "name": "yujie wu",
                "org": ""
            },
            {
                "name": "yu yan",
                "org": ""
            },
            {
                "name": "xiaona xu",
                "org": ""
            },
            {
                "name": "shoubao wang",
                "org": ""
            },
            {
                "name": "tianyi yuan",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2014
    },
    "KRYU2BEf": {
        "id": "KRYU2BEf",
        "title": "Elsholtzia:review of traditional uses,chemistry and pharmacology",
        "abstract": "The chemical constituents,pharmacological activity and traditional uses of 20 species attributed to the genus Elsholtzia(Labiatae)used in China are reviewed and compared.A survey of the literature available shows that these species are used mostly for the treatment of respiratory and gastrointestinal disorders.Additionally,some of these Elsholtzia species show antibacterial,anti-inflammatory,relieving fever,analgesic activities and myocardial ischemia protection.Generally,the essential oils or flavonoids from these plant extracts are assumed to be the active principles.",
        "keywords": [
            "Traditional uses",
            "Chemical constituent",
            "Labiatae",
            "Elsholtzia species"
        ],
        "authors": [
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China;Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao,China"
            },
            {
                "name": "Yi-Tao Wang",
                "org": "Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "中国药学(英文版)",
        "year": 2007
    },
    "fGkbvyig": {
        "id": "fGkbvyig",
        "title": "Pharmacokinetics of fangchinoline and tetrandrine in rats",
        "abstract": "Objective: To investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription. Method: A method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated. The pharmacokinetics of two compounds and two compounds in the effective component group (ECG) of Xiaoxuming decoction were compared. Result: Compared with the single dose of compound experiment results, the tmax of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment. At the meanwhile the rest parameter showed no significant difference. Conclusion: Other components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine, the bioavailability of two compounds were the same as that of the single dose of compound experiment.",
        "keywords": [
            "bioavailability",
            "absorption",
            "analysis",
            "pharmacokinetics",
            "identification",
            "methodology",
            "pharmacodynamics"
        ],
        "authors": [
            {
                "name": "Zhonghong Li",
                "org": "Jiangsu Institute for Drug Control(Jiangsu Institute for Drug Control),Nanjing,China"
            },
            {
                "name": "FAN Xialei",
                "org": "Jiangsu Institute for Food and Drug Control,Nanjing ,China"
            },
            {
                "name": "CAI Meiming",
                "org": "Jiangsu Institute for Food and Drug Control,Nanjing ,China"
            },
            {
                "name": "YANG Zhihong",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "YING Jian",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "QIANG Guifen",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guanhua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Zhongguo Zhongyao Zazhi",
        "year": 2009
    },
    "vADXXyTm": {
        "id": "vADXXyTm",
        "title": "Advanced glycosylation end products and related drug development",
        "abstract": "Glycosylation end products(AGEs) are a mixture containing various structural compounds,which are products of proteins and lipids through non-enzymatic glycosylation.Blocking the pathogenesis of AGEs is expected to be an effective new way to improve the chronic complications of diabetes,to treat Alzheimer's disease,and to ease aging.This article reviews the major source of AGEs in vivo,pathophysiological mechanisms,and the drug development of AGE-inhibitors,AGE-breakers and receptor antagonist agents of progress.",
        "keywords": [
            "AGE-breaker",
            "chronic complications of diabetes",
            "advanced glycosylation end products",
            "AGE-inhibitor",
            "Alzheimer's disease",
            "drug therapy",
            "advanced glycosylation end-product receptor"
        ],
        "authors": [
            {
                "name": "YANG Xiu-ying",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2011
    },
    "HuiDnpdq": {
        "id": "HuiDnpdq",
        "title": "Analysis of Polygala tenuifolia Transcriptome and Description of Secondary Metabolite Biosynthetic Pathways by Illumina Sequencing.",
        "abstract": "Radix polygalae, the dried roots of Polygala tenuifolia and P. sibirica, is one of the most well-known traditional Chinese medicinal plants. Radix polygalae contains various saponins, xanthones, and oligosaccharide esters and these compounds are responsible for several pharmacological properties. To provide basic breeding information, enhance molecular biological analysis, and determine secondary metabolite biosynthetic pathways of P. tenuifolia, we applied Illumina sequencing technology and de novo assembly. We also applied this technique to gain an overview of P. tenuifolia transcriptome from samples with different years. Using Illumina sequencing, approximately 67.2% of unique sequences were annotated by basic local alignment search tool similarity searches against public sequence databases. We classified the annotated unigenes by using Nr, Nt, GO, COG, and KEGG databases compared with NCBI. We also obtained many candidates CYP450s and UGTs by the analysis of genes in the secondary metabolite biosynthetic pathways, including putative terpenoid backbone and phenylpropanoid biosynthesis pathway. With this transcriptome sequencing, future genetic and genomics studies related to the molecular mechanisms associated with the chemical composition of P. tenuifolia may be improved. Genes involved in the enrichment of secondary metabolite biosynthesis-related pathways could enhance the potential applications of P. tenuifolia in pharmaceutical industries.",
        "keywords": [],
        "authors": [
            {
                "name": "Hongling Tian",
                "org": "Research Institute of Economics Crop, Shanxi Academy of Agriculture Science, Fenyang, Shanxi 032200, China."
            },
            {
                "name": "Xiaoshuang Xu",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92 Wucheng Road, Taiyuan, Shanxi 030006, China ; College of Chemistry and Chemical Engineering, Shanxi University, No. 92 Wucheng Road, Taiyuan, Shanxi 030006, China."
            },
            {
                "name": "Fusheng Zhang",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92 Wucheng Road, Taiyuan, Shanxi 030006, China."
            },
            {
                "name": "Yaoqin Wang",
                "org": "Research Institute of Economics Crop, Shanxi Academy of Agriculture Science, Fenyang, Shanxi 032200, China."
            },
            {
                "name": "Shuhong Guo",
                "org": "Research Institute of Economics Crop, Shanxi Academy of Agriculture Science, Fenyang, Shanxi 032200, China."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92 Wucheng Road, Taiyuan, Shanxi 030006, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, No. 92 Wucheng Road, Taiyuan, Shanxi 030006, China ; Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China."
            }
        ],
        "venue": "Comparative and Functional Genomics",
        "year": 2015
    },
    "eAnBx26O": {
        "id": "eAnBx26O",
        "title": "Identification of Cultured and Natural Astragalus Root Based on Monosaccharide Mapping",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ke li",
                "org": ""
            },
            {
                "name": "xia hao",
                "org": ""
            },
            {
                "name": "fanrong gao",
                "org": ""
            },
            {
                "name": "guizhen wang",
                "org": ""
            },
            {
                "name": "zhengzheng zhang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            },
            {
                "name": "xuemei qin",
                "org": ""
            }
        ],
        "venue": "Molecules",
        "year": 2015
    },
    "Pc0r5Woq": {
        "id": "Pc0r5Woq",
        "title": "Goniolactone C, a styryl lactone derivative, inhibits PDGF-BB-induced vascular smooth muscle cell migration and proliferation via PDGFR/ERK signaling.",
        "abstract": "Platelet-derived growth factor-BB (PDGF-BB) and its downstream effector, extracellular signal-regulated kinase 1/2 (ERK1/2) MAP kinase, initiate a multitude of biological effects, including vascular smooth muscle cell (VSMC) proliferation and migration, which are critical events in the initiation and development of restenosis following percutaneous transluminal coronary angioplasty (PTCA). Styryl lactones are natural products that have been demonstrated to possess anti-proliferative activities. Goniolactone C is a styryl lactone derivative that was first extracted from Goniothalamus cheliensis Hu. In the present study, we investigated the effects of goniolactone C on VSMC migration and proliferation. We found that goniolactone C preferentially interacted with cellular systems that rely on PDGF signaling but not those that rely on epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) signaling. Goniolactone C strongly inhibited PDGF-BB-induced VSMC migration and proliferation. goniolactone C-mediated inhibition of VSMC proliferation was associated with cell cycle arrest, while goniolactone C-mediated inhibition of VSMC migration was associated with the suppression of adhesion molecule expression. In addition, goniolactone C directly inhibited PDGFR-β kinase activity, thereby blocking the downstream effector of PDGF-BB. Thus, the results of the present study suggest a novel adjunctive pharmacological strategy that may be used to prevent angioplasty-related restenosis.",
        "keywords": [
            "migration"
        ],
        "authors": [
            {
                "name": "Lan Sun",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Rui Zhao",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Xi Lan",
                "org": "Department of Anesthesiology and Critical Care medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA."
            },
            {
                "name": "Ruoyun Chen",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Si Wang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China. dugh@imm.ac.cn."
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2014
    },
    "VvxyJjjS": {
        "id": "VvxyJjjS",
        "title": "Simultaneous analysis of six effective components in the anti-Alzheimer's disease effective component group of Xiao-Xu-Ming decoction",
        "abstract": "A method based on high performance liquid chromatography (HPLC) was developed for the quantitative determination of six components in an anti-Alzheimer medicine, Xiao-Xu-Ming Decoction, which is an effective prescription in treating stroke and the sequela of stroke by herbalist doctors for thousands years. The effective component group (ECG) was made according to the results of high-throughput screening, and the curative effect of ECG was validated on aging rats. In this method an ODS column was used. The mobile phase consisted of water-formic acid-ethylenediamine (A; 100: 0.1: 0.1, v/v) and methanol-formic acid (B; 100 : 0.05, v/v), eluted with gradient (0 - 5 min, 20% B; 5 - 100 min, 20% B - 40% B; 100 - 140 min, 40% B - 70% B). The flow rate was 1 mL/min. The detection wavelength was set at 240 nm. Under the above separation conditions, six components belonged to two different categories, indicans and alkaloids, were determined simultaneously. The relationships between the concentrations and the peak areas of these six components were all linear. The recoveries of the six components were 99.1% for paeoniflorin, 99.6% for prim-O-glucosylcimifugin, 98.4% for baicalin, 99.9% for 4'-O-beta-D-glucosyl-5-O-methylvisamminol, 99.6% for fangchinoline, and 102.0% for tetrandrine. The relative standard deviations (RSD) were 1.3%, 1.4%, 0.4%, 0.8%, 0.2%, and 1.4%, respectively. This method is simple and reproducible and it can be used for the quality control of the effective component group of Xiao-Xu-Ming Decoction.",
        "keywords": [
            "Anti-Alzheimer's disease",
            "Effective component group (ECG)",
            "High performance liquid chromatography (HPLC)",
            "Traditional Chinese medicine compound prescriptions",
            "Xiao-Xu-Ming decoction"
        ],
        "authors": [
            {
                "name": "Zhonghong Li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Kunyi Ni",
                "org": "China Pharmaceutical University(China Pharmaceutical University),Nanjing,China"
            },
            {
                "name": "Guanhua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Se pu = Chinese journal of chromatography / Zhongguo hua xue hui",
        "year": 2007
    },
    "mGQX3xaS": {
        "id": "mGQX3xaS",
        "title": "Kaempferol alleviates LPS-induced neuroinflammation and BBB dysfunction in mice via inhibiting HMGB1 release and down-regulating TLR4/MyD88 pathway.",
        "abstract": "Kaempferol is a natural flavonoid with many biological activities including anti-oxidation and anti-inflammation. Nevertheless, its anti-neuroinflammation role and the relevant mechanism remain unclear. The present study was to investigate effects of kaempferol against LPS-induced neuroinflammation and blood-brain barrier dysfunction as well as the mechanism in mice. BALB/c mice were treated with LPS 5mg/kg to induce inflammation after pre-treatment with kaempferol 25, 50, or 100mg/kg for 7days. The results showed that kaempferol reduced the production of various pro-inflammatory factors and inflammatory proteins including IL-1β, IL-6, TNF-α, MCP-1, COX-2 and iNOS in brain tissues. In addition, kaempferol also protected BBB integrity and increased BBB related proteins including occludin-1, claudin-1 and CX43 in brain of LPS-induced mice. Furthermore, kaempferol significantly reduced HMGB1 level and suppressed TLR4/MyD88 inflammatory pathway in both transcription level and translation level. These results collectively suggested that kaempferol might be a promising neuroprotective agent for alleviating inflammatory responses and BBB dysfunction by inhibiting HMGB1 release and down-regulating TLR4/MyD88 inflammatory pathway.",
        "keywords": [
            "Blood-brain barrier (BBB)",
            "High-mobility group protein 1 (HMGB1)",
            "Kaempferol",
            "Lipopolysaccharide (LPS)",
            "Myeloid differentiation factor 88 (MyD88)",
            "Toll-like receptor-4 (TLR4)"
        ],
        "authors": [
            {
                "name": "Xiao Cheng",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Ying-Lin Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Huan Yang",
                "org": "Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yue-Hua Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: wangyuehua@pku.org.cn."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "International immunopharmacology",
        "year": 2018
    },
    "H3u4CCed": {
        "id": "H3u4CCed",
        "title": "Over-expressed human amyloid precursor protein depressed M cholinergic receptor binding in SH-SY5Y cells",
        "abstract": "Objective To observe the effect of over-expressed amyloid procursor protein(APP) gene on the cholinergic receptor binding and the ChAT activity in human neuroblastoma cell line SH-SY5Y.Methods SH-SY5Y cells were transfected with pCMV695 plasmid containing wild type human APP695 gene by Lipofectamine 2000 method.The expression of APP was detected by Western blot.Aβ contents were test by ELISA assay in over-expression SH-SY5Y cell clones(SH-SY5Y-APP).The special binding of muscarinic and nicotinic cholinergic receptors in those Aβ-overproducing cell clones was determined by radio-ligand binding method.The cholinergic acetyl transferase(ChAT) activity was assayed by radiao-immunoassay.Results No evident morphologic changes of cytotoxicity were detected after transfection.When Aβ production was 2～2.6 times as much as that of normal cells,muscarinic receptor binding was decreased from 18.5 % to 21.9 %(P<0.05).However,no alterations in nicotinic receptor binding and the ChAT activity were found.Conclusion Muscarinic receptor binding inhibition was shown before cytotoxicity,nicotinic receptor binding and ChAT activity changes in SH-SY5Y-APP.It is suggested that the increase of Aβ production could independently cause the cholinergic dysfunction in early stage of AD brain tissues by muscarinic receptor binding inhibition.",
        "keywords": [
            "receptor",
            "β-amyloid(Aβ)peptide",
            "cholinergic",
            "Alzheimer's disease(AD)",
            "amyloid precursor protein(APP)"
        ],
        "authors": [
            {
                "name": "RUAN Can-jun",
                "org": "Institute of Basic Medical Sciences,CAMS & PUMC,Beijing "
            },
            {
                "name": "WANG Shu",
                "org": "Institute of Basic Medical Sciences,CAMS & PUMC,Beijing "
            },
            {
                "name": "SUN Lan",
                "org": "Institute of Basic Medical Sciences,CAMS & PUMC,Beijing "
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,CAMS & PUMC,Beijing ,China"
            }
        ],
        "venue": "Basic & Clinical Medicine",
        "year": 2007
    },
    "QRyrxhaK": {
        "id": "QRyrxhaK",
        "title": "Research progress of virtual screening aided drug discovery]",
        "abstract": "In the process of new drug discovery, the application of virtual screening can enrich active compounds, reduce the cost of drug screening, and increase the feasibility of drug screening. Therefore virtual screening technology has become an important approach for new drug discovery. As virtual screening and bioactivity screening possess different advantages, their combination can effectively promote new drug discovery. In the present paper, the application and the trend of removal of non-drug compounds, removal of false positive compounds, pharmacophore searching, molecular docking, and molecular similarity in the process of drug discovery are introduced in order to obtain more benefit from virtual screening strategy for new drug discovery.",
        "keywords": [
            "molecular similarity",
            "molecular docking",
            "non-drug compound",
            "pharmacophore",
            "virtual screening"
        ],
        "authors": [
            {
                "name": "Ai-Lin Liu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing , China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing , China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2009
    },
    "EV2Wf6kW": {
        "id": "EV2Wf6kW",
        "title": "Simultaneous quantification of eighteen constituents in traditional Chinese medicine XiaoShuanTongLuo by UPLC-MS/MS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yan zhao",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "k7nPzxK2": {
        "id": "k7nPzxK2",
        "title": "Research progress of xanthine oxidoreductase in biological functions and its inhibitor development",
        "abstract": "xanthine oxidoreductase(XOR)is a member of the molybdoenzyme family and best known for its catalytic role in purine degradation, metabolizing hypoxanthine and xanthine to uric acid with concomitant generation of superoxide and hydrogen peroxide. In addition to its role in the pathophysiology of hyperuricaemia and gout, the role for XOR beyond purine metabolism was first suggested in ischaemia-reperfusion injury, there is growing evidence that it also participates in endothelial dysfunction, hypertension and heart failure. Importantly, the XOR inhibitor attenuates dysfunction especially in heart failure caused by XOR in these disease states. Attention to the broader range of XOR bioactivity in the cardiovascular system has prompted strong interest based XOR drug development by pharmaceuticals company.",
        "keywords": [
            "ischaemia-reperfusion injury",
            "drug development",
            "xanthine oxidoreductase",
            "reactive oxygen species",
            "heart failure"
        ],
        "authors": [
            {
                "name": "ZHU Shen-yin",
                "org": " Department of Clinical Pharmacology, the First Affiliated Hospital of Chongqing University of Medical Science, Chongqing , China; Institute of Materia Medica, Chinese Academy of Medical Science, Beijing , China"
            },
            {
                "name": "ZHOU Yuan-da",
                "org": " Department of Clinical Pharmacology, the First Affiliated Hospital of Chongqing University of Medical Science, Chongqing , China"
            },
            {
                "name": "DU Guan-hua",
                "org": " Institute of Materia Medica, Chinese Academy of Medical Science, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Clinical Pharmacology and Therapeutics",
        "year": 2006
    },
    "7a1gRt01": {
        "id": "7a1gRt01",
        "title": "Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro.",
        "abstract": "Baicalein, a flavonoid obtained from the root of Chinese medicinal herb Scutellaria baicalensis, has been shown to exert a protective effect on neurons against several neuronal insults. The aim of this study was to explore the neuroprotective effect of baicalein in 6-hydroxydopamine (6-OHDA)-induced experimental parkinsonism in vitro and in vivo. In in vitro experiments, we found that baicalein (0.5, 5 microg/mL) could significantly ameliorate the 6-OHDA-induced SH-SY5Y cell apoptosis from 31.56% in the 6-OHDA group to 18.90%, 21.61% respectively, and also promote neurite outgrowth of PC12 cell. In in vivo experiments, baicalein had no effect on apomorphine (APO)-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA-lesioned rats. The burst frequency and amplitude are 13.43%, 35.18% compared to 6-OHDA group. Moreover, baicalein treatment could also increase tyrosine hydroxylase (TH)-positive neurons to 265.52% of the 6-OHDA group. The neuroprotective action of baicalein was coincident with an attenuated astroglial response within the substantia nigra. Neuroprotective effect of baicalein as demonstrated by the increasing the number of dopaminergic neurons may have been, in part, caused by anti-apoptotic, pro-differentiation and anti-inflammatory mechanisms of baicalein. Therefore, baicalein can be a promising candidate for prevention or treatment of Parkinson's disease, owing to its anti-apoptotic, pro-differentiation and anti-inflammatory action.",
        "keywords": [
            "Parkinson's disease",
            "Baicalein",
            "6-Hydroxydopamine",
            "Neuroprotective"
        ],
        "authors": [
            {
                "name": "Xin Mu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guorong He",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Yinxia Cheng",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Xiaoxiu Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Bei Xu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guanhua Du",
                "org": ""
            }
        ],
        "venue": "Pharmacology, biochemistry, and behavior",
        "year": 2009
    },
    "SSYkIdlt": {
        "id": "SSYkIdlt",
        "title": "Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats.",
        "abstract": "Processes of synaptic plasticity, such as long-term potentiation (LTP), has been considered a cellular correlate of learning and memory and many neurological disorders accompanied by cognitive deficits exhibit abnormal synaptic function. This emerging concept is exemplified by Alzheimer's disease. Mounting evidence suggests that Alzheimer's disease begins with subtle alterations of hippocampal synaptic efficacy prior to frank neuronal degeneration, which make it critical to identify LTP enhancers to slow down or stop the progression of Alzheimer's disease. In this study, we found flavonoid luteolin could enhance basal synaptic transmission and facilitate the induction of LTP by high frequency stimulation in the dental gyrus of rat hippocampus. Furthermore, we investigated the effects of luteolin on chronic cerebral hypoperfusion-induced spatial learning dysfunction and LTP impairment in rat. The results showed chronic cerebral hypoperfusion produced by 2-vessel occlusion significantly impaired spatial learning and memory, and luteolin reversed the learning and memory deficit. 2-vessel occlusion resulted in dramatic inhibition of LTP formation in the hippocampus and luteolin significantly rescued the LTP impairment. These results demonstrate that luteolin not only directly modulates LTP formation, but also protects synapses from the detrimental effects of chronic cerebral hypoperfusion on LTP formation, which may contribute to the protective effects of luteolin on learning and memory. By immunoblotting, we found the effects of luteolin on LTP and memory may due to the activation of cAMP response element-binding protein (CREB). Therefore, flavonoid luteolin shows great potential as a novel treatment agent for protecting synaptic function and enhancing memory in neurodegenerative disorders.",
        "keywords": [
            "basal synaptic transmission",
            "long-term potentiation",
            "chronic cerebral hypoperfusion",
            "2-vessel occlusion",
            "synaptic plasticity",
            "alzheimer's disease",
            "luteolin",
            "learning and memory",
            "cognitive function",
            "spatial learning",
            "synaptic transmission",
            "camp response element binding protein",
            "long term potentiation"
        ],
        "authors": [
            {
                "name": "Bei Xu",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Xiao-Xiu Li",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Guo-Rong He",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Juan-Juan Hu",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Xin Mu",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Shuo Tian",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China"
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2010
    },
    "SZ3Nb7ca": {
        "id": "SZ3Nb7ca",
        "title": "Evaluation of antihypertensive effects of salmon protein hydrolysates",
        "abstract": "Objective In these studies,the antihypertensive effects of salmon protein hydrolysates(SMs) were investigated in spontaneously hypertensive rats(SHR).Methods SMs were administered orally a single dose and multi-doses to spontaneously hypertensive rats(SHR) for 4 days and blood pressures were measured in unanesthetized SHR using the tail cuff method on the first and fourth day after medication.Results The systolic blood pressure(SBP) of SHR decreased after oral administration of SM-1 and SM-2(1.5 g·kg-1 of body weight),and was significantly differed from the control group on the first day.The SBP decreased significantly in all SMs groups and were significantly differed from the control group on the fourth day.Conclusion These results suggest that SMs have antihypertensive activity in SHR.",
        "keywords": [
            "antihypertensive effect",
            "spontaneously hypertensive rats(SHR)",
            "protein hydrolysates",
            "salmon"
        ],
        "authors": [
            {
                "name": "FANG Lian-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHU Xiao-ming",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHANG Ran",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "HU Juan-juan",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Marine Drugs",
        "year": 2008
    },
    "ShVjON5x": {
        "id": "ShVjON5x",
        "title": "Efficacy of low-molecular-weight heparin on the outcomes of IVF/ICSI pregnancy in non-thrombophilic women: a meta-analysis.",
        "abstract": "Our results suggested that LMWH had no effect on pregnancy success rate in non-thrombophilic women undergoing IVF/ICSI treatment. However, to justify the use of LMWH in clinical practice, multicentre trials are still necessary. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "IVF/ICSI",
            "low-molecular-weight heparin",
            "non-thrombophilia",
            "pregnancy outcomes",
            "randomized controlled trial"
        ],
        "authors": [
            {
                "name": "Xiu-Li Yang",
                "org": "Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing."
            },
            {
                "name": "Fei Chen",
                "org": "Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing."
            },
            {
                "name": "Xiu-Ying Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica of Peking, Union Medical College, Beijing, China."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Drug Target and Screening Research, Institute of Materia Medica of Peking, Union Medical College, Beijing, China."
            },
            {
                "name": "Yang Xu",
                "org": "Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing."
            }
        ],
        "venue": "Acta obstetricia et gynecologica Scandinavica",
        "year": 2018
    },
    "xoyWyeDG": {
        "id": "xoyWyeDG",
        "title": "Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice: Therapeutic effect of MSL on RA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wenyu xin",
                "org": ""
            },
            {
                "name": "chao huang",
                "org": ""
            },
            {
                "name": "xue zhang",
                "org": ""
            },
            {
                "name": "sheng xin",
                "org": ""
            },
            {
                "name": "yiming zhou",
                "org": ""
            },
            {
                "name": "xiaowei ma",
                "org": ""
            },
            {
                "name": "yongjie li",
                "org": ""
            },
            {
                "name": "sibai zhou",
                "org": ""
            },
            {
                "name": "dongming zhang",
                "org": ""
            },
            {
                "name": "tiantai zhang",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "British Journal of Pharmacology",
        "year": 2014
    },
    "jqXe5Acs": {
        "id": "jqXe5Acs",
        "title": "High throughput screening for glutathione S-transferase inhibitors",
        "abstract": "To identify the inhibitor of glutathione S-transferase (GST), a high-throughput screening method was established in a 384-well microplate with total 35 microL volume, and the absorbance at 340 nm is detected. The concentrations of substrates, CDNB and GST were determined by chromatometry. The optimal enzyme kinetics reaction time and temperature are 2 h and 30 degrees C , respectively. The established model was evaluated by NaOCl, a known GST inhibitor, and the parameter Z' was 0.77, which showed a high feasibility and stability of the assay. A total of 31,098 compounds were screened, of which 4 compounds were shown to inhibit GST activity, high inhibiting activity for their IC50 of GST inhibition was 3.94, 4.05, 74.85, and 77.41 mg x L(-1), separately. The results indicated that the colorimetric method by using CDNB and GSH as substrate is stable, sensitive, reproducible and also suitable for high throughput screening.",
        "keywords": [
            "Glutathione S-transferase",
            "Glutathione S-transferase inhibitor",
            "High throughput screening"
        ],
        "authors": [
            {
                "name": "Dan-Shen Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tian-Tai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shao-Jing Li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2008
    },
    "2uHgFq30": {
        "id": "2uHgFq30",
        "title": "Advances in the Research of Erythropoietm-Mediated Signal Pathway and Its Biological Effect",
        "abstract": "Erythropoietin (EPO) can activate many signal pathways by binding to EPO receptors, such as Jak-STAT pathway, ras-MAPK pathway, PI3K pathway and so on, thereby serving its functions by changing the specific gene transcription in cell nuecli.Recent researches showed that EPO has extensive effects on brain, heart, liver, kidney etc.It can protect nervous and cardiovascular systems.",
        "keywords": [
            "erythropoietin",
            "protective effect",
            "signal pathway"
        ],
        "authors": [
            {
                "name": "WANG Jinhua",
                "org": " Institute of Materia Medico, Chinese Academy of Medical Science & Peking Union Medical College,Beijing, , China"
            },
            {
                "name": "DU Guanhua",
                "org": " Institute of Materia Medico, Chinese Academy of Medical Science & Peking Union Medical College,Beijing, , China"
            }
        ],
        "venue": "Journal of Medical Molecular Biology",
        "year": 2005
    },
    "3hrgSEj3": {
        "id": "3hrgSEj3",
        "title": "Progress in pharmacological study and the underlying mechanism of baicalein and baicalin",
        "abstract": "Baicalein and baicalin are important components of traditional Chinese herb,Scutellariae Radix.Many studies have shown that baicalein and baicalin have the activities of anti-bacteria,anti-virus,anti-tumor,anti-inflammation,anti-oxidation,protecting the liver function,dispelling heat and relieving pain,treating heart blood vessel diseases,and so on.This article reviews the developments of studies on its pharmacological action and mechanism and provides theoretical evidences for exploiting of baicalein and baicalin.",
        "keywords": [
            "baicalin",
            "baicalein",
            "mechanism",
            "pharmacology"
        ],
        "authors": [
            {
                "name": "XIN Wen-yu",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "SONG Jun-ke",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "HE Guo-rong",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Beijing Key Laboratory of Drug Target and Screening Research,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2013
    },
    "cWymJ8wm": {
        "id": "cWymJ8wm",
        "title": "Coptisine protects rat heart against myocardial ischemia/reperfusion injury by suppressing myocardial apoptosis and inflammation.",
        "abstract": "Protecting the heart from myocardial ischemia and reperfusion (I/R) damage is the focus of intense research. Coptisine is an isoquinoline alkaloid isolated from Coptidis Rhizoma. The present study investigated the potential effect of coptisine on myocardial I/R damage in rats and the underlying mechanisms.Electrocardiogram examination showed that the administration of coptisine 10 min before ischemia significantly decreased I/R-induced arrhythmia after 30 min ischemia followed by 3 h reperfusion. The release of cardiac markers was also limited. Echocardiography was performed before ischemia and 24 h post-I/R, separately. The M-mode records showed that the reductions of ejection fraction (EF) and fractional shortening (FS) were attenuated in coptisine-treated rats compared with the I/R rats. Similar results were obtained with Evans Blue/triphenyl tetrazolium chloride (TTC) staining, in which coptisine notably reduced infarct size. Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay demonstrated coptisine suppressed myocardial apoptosis, which may be related to the upregulation of Bcl-2 protein and inhibition of caspase-3 activation. Coptisine treatment also attenuated the proinflammatory cytokines including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in heart tissue. Additionally, Western blot and immunohistochemical analysis showed that coptisine markedly reduced Rho, Rho-kinase 1 (ROCK1), and ROCK2 expression and attenuated the phosphorylation of myosin phosphatase targeting subunit-1, a downstream target of ROCK.Coptisine exerts pronounced cardioprotection in rats subjected to myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway.",
        "keywords": [
            "apoptosis",
            "rho-kinase (rock)",
            "coptisine",
            "ischemia/reperfusion (i/r)",
            "inflammation"
        ],
        "authors": [
            {
                "name": "Jing Guo",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shou-Bao Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tian-Yi Yuan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yu-Jie Wu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yu Yan",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li Li",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiao-Na Xu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li-Li Gong",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Hai-Lin Qin",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Atherosclerosis",
        "year": 2013
    },
    "cEYYQTg9": {
        "id": "cEYYQTg9",
        "title": "Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition.",
        "abstract": "Epoxyeicosatrienoic acids (EETs) and their regulating enzyme soluble epoxide hydrolase (sEH) have been associated with ischemic stroke. Salvianolic acid A (SAA) is proved to display potent cerebroprotection. However, little information is available about the link between them. This study aimed to investigate whether SAA exhibits its protective effects in rats subjected to middle cerebral artery occlusion (MCAO) through sEH and EETs. The results showed that SAA treatment ameliorated neurological deficits and reduced infarct volume. Notably, the beneficial effects of SAA were attenuated by co-administration of (14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE)), a putative selective EETs antagonist. Furthermore, SAA increased the 14,15-EET levels in the blood and brain of sham and MCAO rats. Assay for hydrolase activity showed that 1 and 3 mg/kg of SAA significantly diminished brain sEH activity of MCAO rats. A fluorescent assay in vitro indicated that SAA could inhibit recombinant human sEH activity in a concentration-dependent manner (IC(50) = 1.62 μmol/l). Immunohistochemical analysis showed that SAA at the doses of 1 and 3 mg/kg significantly decreased sEH protein expression in hippocampus CA1 region of MCAO rats. In conclusion, cerebral protection of SAA is mediated, at least in part, via inhibiting sEH to increase EETs levels.",
        "keywords": [
            "cerebral ischemic damage",
            "epoxyeicosatrienoic acids",
            "salvianolic acid a",
            "soluble epoxide hydrolase"
        ],
        "authors": [
            {
                "name": "Shou-Bao Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines(State Key Laboratory of Natural Active Substance and Function,State Key Laboratory of Bioactive Substance,State Key Laboratory of Natural Active Substances and Functions,State Key Laboratory of Bioactive Substance and Function of Natural Medicines),Beijing,China"
            },
            {
                "name": "Xiao-Bin Pang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yan Zhao",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yue-Hua Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines(State Key Laboratory of Natural Active Substance and Function,State Key Laboratory of Bioactive Substance,State Key Laboratory of Natural Active Substances and Functions,State Key Laboratory of Bioactive Substance and Function of Natural Medicines),Beijing,China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiu-Ying Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines(State Key Laboratory of Natural Active Substance and Function,State Key Laboratory of Bioactive Substance,State Key Laboratory of Natural Active Substances and Functions,State Key Laboratory of Bioactive Substance and Function of Natural Medicines),Beijing,China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of Asian natural products research",
        "year": 2012
    },
    "NNkYL6wk": {
        "id": "NNkYL6wk",
        "title": "Molecular Modeling on Berberine Derivatives toward BuChE:An Integrated Study with QSAR Models, Molecular Docking, and Molecular Dynamics Simulations.",
        "abstract": "A dataset of 67 berberine derivatives for the inhibition of butyrylcholinesterase (BuChE) was studied based on the combination of QSAR models, molecular docking, and molecular dynamics (MD) methods. First, a series of berberine derivatives were reported, and their inhibitory activities toward butyrylcholinesterase (BuChE) were evaluated. By 2D-QSAR studies, the best model built by partial least-square (PLS) had a conventional correlation coefficient of the training set (R(2) ) of 0.883, a cross-validation correlation coefficient (Q(2) cv ) of 0.777 and a conventional correlation coefficient of the test set (R(2) pred ) of 0.775. The model was also confirmed by Y-randomization examination. In addition, the molecular docking and molecular dynamics (MD) simulation were performed to better elucidate the inhibitory mechanism of three typical berberine derivatives (berberine, C2 and C55) toward BuChE. The predicted binding free energy results were consistent with the experimental data and showed that the van der Waals energy term (ΔEvdw ) difference played the most important role in differentiating the activity among the three inhibitors (berberine, C2 and C55). The developed QSAR models provide details on the fine relationship linking structure and activity and offer clues for structural modifications, and the molecular simulation helps to understand the inhibitory mechanism of the three typical inhibitors. In conclusion, the results of this study provide useful clues for new drug design and discovery of BuChE inhibitors from berberine derivatives. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "Berberine derivatives",
            "QSAR models",
            "butyrylcholinesterase",
            "molecular dynamics (MD) simulation"
        ],
        "authors": [
            {
                "name": "Jiansong Fang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Xiaocong Pang",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Ping Wu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Rong Yan",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Li Gao",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Chao Li",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Wenwen Lian",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Qi Wang",
                "org": "Institute of Clinical Pharmacology, Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510006, PR China."
            },
            {
                "name": "Ai-lin Liu",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            },
            {
                "name": "Guan-hua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, PR China."
            }
        ],
        "venue": "Chemical biology & drug design",
        "year": 2015
    },
    "eyZP7N63": {
        "id": "eyZP7N63",
        "title": "Effect of Icariin on learning and memory,cortex oxidative stress in ovarietomized senescence-accelerated prone/8 female mice",
        "abstract": "Objective To investigate the effects of icariin(ICA)on learning and memory,and antioxidative ability of ovariectomized senescence accelerated prone/8 female mice.Methods Female mice with ovariectomized senescence-accelerated prone/8(SAP8)at the age of 10 months were divided into model group,normal group and sham operation group.Experimental group was further divided into senescence-accelerated resistant mouse1(SAMR1)group,sham operation group,SAP8 group,donepezil group,stilbestrol group,ICA75mg/kg group and ICA150mg/kg group.After 8 weeks of intragastric administration of ICA,Morris water maze test was used to test the effects of ICA on learning and memory in SAMR1 and SAP8 groups.NO and MDA level,and SOD and GSH-Px activity in cerebral cortex were measured.Results ICA(150mg/kg or 75mg/kg)could significantly improve the latency on place navigation of OVX SAP8,space exploration,and residence times on quadrant of platform,reduce MDA and NO level,and increase SOD and GSH-Px activity in cerebral cortex(P<0.05).Conclusion ICA can improve learning and memory of ovariectomized SAP8 female mice.",
        "keywords": [
            "Memory",
            "Learning",
            "Icariin",
            "Senescence Accelerated Mouse Prone/8",
            "Antioxydant"
        ],
        "authors": [
            {
                "name": "LIU Dong-hua",
                "org": " Life and Environment Science Research Center,Harbin University of Commerce,Harbin ,China"
            },
            {
                "name": "WU Man-gang",
                "org": " Life and Environment Science Research Center,Harbin University of Commerce,Harbin ,China"
            },
            {
                "name": "BI Ming-gang",
                "org": "Institute of Medicinal Plant Development,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Journal of Chinese PLA Postgraduate Medical School",
        "year": 2010
    },
    "oACHnzHC": {
        "id": "oACHnzHC",
        "title": "Cerebral ischemia-reperfusion aggravated cerebral infarction injury and possible differential genes identified by RNA-Seq in rats.",
        "abstract": "Numerous studies have shown that local excessive inflammatory response in brain tissue was an important pathogenesis of secondary injury following cerebral ischemia-reperfusion (I/R). However, the inflammatory-related targets and pathways after cerebral I/R injury are still unclear. This study was to investigate possible targets and mechanisms after cerebral I/R injury. Rats were subjected to transient or permanent middle cerebral artery occlusion (MCAO). Neurological deficit scores test was used to evaluate neurological function. Cerebral infarction was evaluated by MRI, TTC staining and Nissl staining. Microglia activation was detected by immunofluorescence using Iba-1 antibody. Inflammatory factors was detected by ELISA assay. RNA-sequencing transcriptome analysis was processed and the differential genes were verified by real-time quantitative PCR (qPCR) and Western blotting. The results showed that neurological function of rats in I/R group was more severe than that of in I group on the 7 after cerebral I/R. Therefore, the differences between cerebral ischemia and cerebral I/R for 7 days were studied in further study. The results showed that the levels of pro-inflammatory factors in I/R group were higher and the levels of anti-inflammatory factors were lower than that of in I group. KEGG pathway and gene network enrichment analysis revealed that some common differential up- and down-regulated genes were involved in most of significant pathways. These common differential up-regulated genes belonged to TLR4/MYD88 inflammatory signaling pathway and common differential down-regulated genes belonged to HRAS/RAF1 neurotrophic signaling pathway. Interestingly, according to the genetic interaction analysis of string database, these up-regulated differential genes might promote the development of inflammation, while the down-regulated differential genes might inhibit the development of inflammation. Furthermore, qPCR and WB results verified that these pro-inflammatory genes in the I/R group was higher than that in the I group, while possible anti-inflammatory genes in the I/R group was lower than that in the I group. It is concluded that TLR4/MYD88 inflammatory signaling pathway and HRAS/RAF1 neurotrophic signaling pathway may be play different roles after cerebral I or I/R and may be therapeutic targets for stroke recovery.",
        "keywords": [
            "Cerebral ischemia",
            "Cerebral ischemia reperfusion",
            "Neuroinflammation",
            "RNA-seq"
        ],
        "authors": [
            {
                "name": "Xiao Cheng",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Ying-Lin Yang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Wei-Han Li",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Man Liu",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China."
            },
            {
                "name": "Yue-Hua Wang",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: wangyuehua@pku.org.cn."
            },
            {
                "name": "Guan-Hua Du",
                "org": "State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Target Identification, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Electronic address: dugh@imm.ac.cn."
            }
        ],
        "venue": "Brain research bulletin",
        "year": 2019
    },
    "42aeDHmP": {
        "id": "42aeDHmP",
        "title": "Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats.",
        "abstract": "Salvianolic acid A (SalA) is one of the main active ingredients of Salvia miltiorrhizae. The objective of this study was to evaluate the effect of SalA on the diabetic vascular endothelial dysfunction (VED). The rats were given a high-fat and high-sucrose diet for 1 month followed by intraperitoneal injection of streptozotocin (30 mg/kg). The diabetic rats were treated with SalA (1 mg/kg, 90% purity) orally for 10 weeks after modeling, and were given a high-fat diet. Contractile and relaxant responses of aorta rings as well as the serum indications were measured. Our results indicated that SalA treatment decreased the level of serum Von Willebrand factor and ameliorated acetylcholine-induced relaxation and KCl-induced contraction in aorta rings of the diabetic rats. SalA treatment also reduced the serum malondialdehyde, the content of aortic advanced glycation end products (AGEs), and the nitric oxide synthase (NOS) activity as well as the expression of endothelial NOS protein in the rat aorta. Exposure of EA.hy926 cells to AGEs decreased the cell viability and changed the cell morphology, whereas SalA had protective effect on AGEs-induced cellular vitality. Our data suggested that SalA could protect against vascular VED in diabetes, which might attribute to its suppressive effect on oxidative stress and AGEs-induced endothelial dysfunction.",
        "keywords": [
            "diabetes",
            "advanced glycation end products",
            "vascular endothelial dysfunction",
            "salvianolic acid a",
            "oxidative stress"
        ],
        "authors": [
            {
                "name": "Xiu-Ying Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Gui-Fen Qiang",
                "org": "Aerospace Center Hospital(Aerospace Center Hospital,Central Hospital of Aerospace Bureau,Thirteen Department of Aerospace Central Hospital),Beijing,China"
            },
            {
                "name": "Li Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xiao-Ming Zhu",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shou-Bao Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Lan Sun",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Hai-Guang Yang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of Asian natural products research",
        "year": 2011
    },
    "a3cC5k4r": {
        "id": "a3cC5k4r",
        "title": "Extraction, Characterization, Antitumor and Immunological Activities of Hemicellulose Polysaccharide from Astragalus radix Herb Residue.",
        "abstract": " have been frequently used for clinical application in China, and the herb residues of  turn out to be a waste of resources. To escape from this, the medicine value of  herb residues is mined in this article. We isolated hemicellulose polysaccharide AX-I-3b from  herb residues by fractional extraction. Monosaccharide-composition analysis revealed that AX-I-3b consisted of arabinose, xylose, and glucose with a molar ratio of 10.4:79.3:1.1. Methylation, NMR and FT-IR analyses showed that AX-I-3b monosaccharide residue was linked as follows: →2,3,4)-β-d-Xylp-(1→, →4)-β-d-Arap-(1→, →4)-β-d-Glcp-(1→. Then, we found that AX-I-3b exhibited antitumor activity against lung cancer in vitro and vivo through MTT assay and xenograft tumor model. Mechanistically, AX-I-3b induced apoptosis in lung cancer cells and xenograft tumors, which is evidenced by the up-regulation of p53, Bax and cleaved caspase-3, and the down-regulation of Bcl-2. Moreover, AX-I-3b synergistically improved the therapeutic ability of cisplatin in xenograft tumors model. Furthermore, AX-I-3b treatment effectively improved the immune organ index, the percentage of spleen lymphocyte subsets and serum cytokine levels in lung cancer mice, supporting that AX-I-3b showed immunomodulatory activity. In conclusion, our results identified AX-I-3b as an antitumor and immunomodulatory agent, providing a new insight into the reutilization of  herb residue.",
        "keywords": [
            "Astragalus radix herb residue",
            "antitumor",
            "characterization",
            "hemicellulose polysaccharide",
            "immunomodulatory"
        ],
        "authors": [
            {
                "name": "Ke Li",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China. like@sxu.edu.cn."
            },
            {
                "name": "Shuying Li",
                "org": "College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China. shuyingli_01@163.com."
            },
            {
                "name": "Di Wang",
                "org": "College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China. m15735653961@163.com."
            },
            {
                "name": "Xiaoxia Li",
                "org": "Shanxi Fruit Industry Work Station, Taiyuan 030001, China. 15735652079@163.com."
            },
            {
                "name": "Xingkang Wu",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China. wuxingkang@sxu.edu.cn."
            },
            {
                "name": "Xiaojie Liu",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China. liuxiaojie@sxu.edu.cn."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China. dugh@imm.ac.cn."
            },
            {
                "name": "Xianrong Li",
                "org": "Shanxi Academy of Traditional Chinese Medicine, Taiyuan 030000, China. XRLi-01@163.com."
            },
            {
                "name": "Xuemei Qin",
                "org": "Key Laboratory of Chemical Biology and Molecular Engineering Ministry, Shanxi University, Taiyuan 030006, China. qinxm@sxu.edu.cn."
            },
            {
                "name": "Yuguang Du",
                "org": "Institute of process engineering, Chinese Academy of Sciences, Beijing 100190, China. ygdu@ipe.ac.cn."
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2019
    },
    "CYBjxWxM": {
        "id": "CYBjxWxM",
        "title": "Determination of R-enantiomer and other Related Substances in Levetiracetam by HPLC",
        "abstract": "Objective:To establish a chiral chromatographic separation method and RP-HPLC method to determine R-enantiomer and the other related substances in levetiracetam.Method:An inertsil C_(18) column(250 mm×4.6 mm,5μm) with the mobile phase of acetonitrile-dipotassium hydrogenphosphate solution(10:90) was used in the RP-HPLC method.The flow rate was 1.0 ml·min~(-1), the UV detection wavelength was set at 205 nm and the column temperature was at 30℃.A DAICEL OD-H column(250 mm×4.6 mm,5μm) with the mobile phase of n-heptane-alcohol-trifluoroacetic acid(83:17:0.1) was used in the chiral chromatographic separation method.The flow rate was 0.5 ml·min~(-1),the UV detection wavelength was set at 205 nm and the column temperature was at 30℃.Result:Levetiracetam and its related substances could be separated well,and the lowest determination limit of levetiracetam was 2 ng in the RP-HPLC method.Levetiracetam was separated from R-enantiomer efficiently,the calibration curve of R-enantiomer was linear within the concentration range of 2-10μg·ml~(-1)(r =0.999 5) and the determination limit was 10 ng in the chiral chromatographic separation method.Conclusion:The two methods are both simple,sensitive,and accurate,and suitable for the determination of R-enantiomer and the other related substances.",
        "keywords": [
            "R-enantiomer",
            "Related substances",
            "RP-HPLC",
            "Chiral chromatographic separation",
            "Levetiracetam"
        ],
        "authors": [
            {
                "name": "Hao Linghua",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health,Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Qi Yan",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health,Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Du Guanhua",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health,Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "Wu Song",
                "org": "State Key Laboratory of Bioactive Substances and Functions of Natural Medicines & Ministry of Health,Key Laboratory of Biosynthesis of Natural Products,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "China Pharmacist",
        "year": 2013
    },
    "zI5MU6q2": {
        "id": "zI5MU6q2",
        "title": "In vitro Antioxidative and Cytotoxic Activities of Schisandra sphenanthera Rehd.et Wils",
        "abstract": "The in vitro antioxidative and cytotoxic activities of the ethanol extracts of Schisandra sphenanthera Rehd.et Wils leaves,stems,roots,and fruits were evaluated.The antioxidative activity of the extracts was assessed by means of two tests:bleaching of DPPH free radical and superoxide anions scavenging assay.The cytotoxic activities were tested by MTT assay.In both tests root extract showed a significant antioxidative effect.The extract of roots also demonstrated cytotoxic activity against tumor cell lines.",
        "keywords": [
            "Schisandra sphenanthera Rehd.et Wils.",
            "cytotoxicity",
            "antioxidative"
        ],
        "authors": [
            {
                "name": "HUANG Feng",
                "org": "Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China;Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "XU Li-jia",
                "org": "Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DU Guan-hua",
                "org": "Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "XIAO Pei-gen",
                "org": "Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2006
    },
    "8VToV7st": {
        "id": "8VToV7st",
        "title": "Abstract 18233: Association of Circulating Levels of Asymmetric Dimethylarginine with Carotid Intima-Media Thickness: Evidence From 5269 Participants",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lan sun",
                "org": ""
            },
            {
                "name": "yongyi bai",
                "org": ""
            },
            {
                "name": "wenyu xin",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2011
    },
    "2l91AVK8": {
        "id": "2l91AVK8",
        "title": "Antithrombotic effects of the effective components group of Xiaoshuantongluo formula in vivo and in vitro.",
        "abstract": "The present study was designed to investigate the antithrombotic effects and underlying mechanisms of the effective components group (ECG) of Xiaoshuantongluo recipe (XECG) and to further verify the rationality and feasibility of ECG-guided methodology in traditional Chinese medicine (TCM) research. The arterial thrombosis model induced by ferric chloride (FeCl3) oxidation and the venous thrombosis model induced by inferior vena cava ligation were established to evaluate the antithrombotic potential of XECG. Our results indicated that XECG significantly prolonged the time to occlusion, activated partial thromboplastin time (APTT), and prothrombin time (PT), and markedly inhibited adenosine diphosphate (ADP)-induced platelet aggregation in the 20% FeCl3-induced arterial thrombosis model. The superoxide dismutase (SOD) activity was significantly increased and the levels of malondialdehyde (MDA) and nitric oxide (NO) were dramatically decreased in the plasma of arterial thrombosis rats after XECG treatment for 12 days. Furthermore, XECG markedly reduced the weight of thrombus formed by inferior vena cava ligation. Additionally, XECG exhibited 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity and protective effect on mitochondrial lipid peroxidation. In summary, XECG played an important role in the prevention of thrombosis through interacting with multiple targets, including inhibition of platelet aggregation and coagulation and repression of oxidative stress. The ECG-guided methodology was validated as a feasible tool in TCM research.",
        "keywords": [
            "Effective components group",
            "Oxidative stress",
            "Platelet aggregation",
            "Radical scavenging",
            "Thrombosis",
            "Traditional Chinese medicine"
        ],
        "authors": [
            {
                "name": "Yan Zhao",
                "org": "Qingdao Municipal Hospital, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266011, China; Qingdao University, Qingdao 266071, China."
            },
            {
                "name": "Xiao Chu",
                "org": "Qingdao Municipal Hospital, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266011, China."
            },
            {
                "name": "Xiao-Bin Pang",
                "org": "Pharmaceutical Institute, Henan University, Kaifeng 475004, China."
            },
            {
                "name": "Shao-Hua Wang",
                "org": "Qingdao Municipal Hospital, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266011, China."
            },
            {
                "name": "Guan-Hua DU",
                "org": "National Centre for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050, China."
            }
        ],
        "venue": "Chinese journal of natural medicines",
        "year": 2015
    },
    "xhIV7Yoa": {
        "id": "xhIV7Yoa",
        "title": "Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats",
        "abstract": "Quercetin, a flavonoid present in many plants, is reported to be effective in models of neurodegenerative diseases. The aim of the present study was to evaluate the anti-tremor effects of quercetin in 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinsonu0027s disease. In rats, quercetin had no effect on apomorphine-induced rotations, but it could significantly attenuate muscle tremor of 6-OHDA lesioned rats. Interestingly, quercetin could decrease the burst frequency in a dose- and time-dependent manner. These results suggest that quercetin may have a protective effect on models to mimic muscle tremors of Parkinsonu0027s disease. This effect of quercetin may be associated with serotonergic system, but further study is needed.",
        "keywords": [],
        "authors": [
            {
                "name": "xin mu",
                "org": ""
            },
            {
                "name": "xia yuan",
                "org": ""
            },
            {
                "name": "lida du",
                "org": ""
            },
            {
                "name": "guorong he",
                "org": ""
            },
            {
                "name": "guanhua du",
                "org": ""
            }
        ],
        "venue": "Journal of Asian Natural Products Research",
        "year": 2015
    },
    "Xme8F5y4": {
        "id": "Xme8F5y4",
        "title": "Synthesis and anti-nociceptive and anti-inflammatory effects of gaultherin and its analogs.",
        "abstract": "The synthesis of gaultherin (1) and its analogs was carried out to provide 11 glycosides under phase-transfer catalytic conditions. The activities of all synthesized compounds were evaluated by nitric oxide production inhibitory assay in vitro. Methyl 2-O-(4-O-β-d-galactopyranosyl)-β-d-glucopyranosylbenzoate (5f) showed significantly anti-nociceptive and anti-inflammatory effects by the evaluation in vivo. Structure-activity relationships within these compounds were discussed.",
        "keywords": [
            "anti-nociceptive",
            "phase-transfer catalytic method",
            "anti-inflammatory",
            "analogs",
            "gaultherin"
        ],
        "authors": [
            {
                "name": "Chao Wang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Tian-Tai Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Guan-Hua Du",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Dong-Ming Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            }
        ],
        "venue": "Journal of Asian natural products research",
        "year": 2011
    },
    "ffzgtdcf": {
        "id": "ffzgtdcf",
        "title": "Endothelium-dependent and -independent relaxation induced by pinocembrin in rat aortic rings.",
        "abstract": "The aim of present study was to evaluate the vasorelaxant effects of the flavonone pinocembrin and its possible mechanisms in isolated rat aortic rings. Pinocembrin (5 approximately 100 microM) induced relaxation in aortic rings pre-contracted with norepinephrine (NE, 1 microM) or KCl (60 mM), with pEC(50) value 4.37+/-0.02 and 4.52+/-0.04. Pretreatment with pinocembrin (30 or 50 microM) also inhibited contractile responses to NE and KCl. The vasorelaxant effect of pinocembrin relied on intact endothelium partially, and incubation with n(omega)-nitro-l-arginine methyl ester (l-NAME, 100 microM) or methylene blue (10 microM) significantly inhibited the effect, however indomethacin (5 microM) had no influence on the action. In endothelium-denuded rings, the vasorelaxant effect of pinocembrin was reduced by glibenclamide (10 microM), tetraethylammonium (5 mM) and 4-aminopyridine (100 microM). Pinocembrin also reduced NE-induced transient contraction in Ca(2+)-free solution and inhibited contraction induced by increasing external calcium in Ca(2+)-free medium plus 60 mM KCl. Our results suggest that pinocembrin induces relaxation in rat aortic rings through an endothelium-dependent pathway, involving NO-cGMP, and also through an endothelium-independent pathway, opening K(+) channels and blockade of Ca(2+) channels.",
        "keywords": [
            "aorta",
            "pinocembrin",
            "vasorelaxant",
            "calcium",
            "nitric oxide"
        ],
        "authors": [
            {
                "name": "Xiao-Ming Zhu",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Lian-Hua Fang",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Yu-Juan Li",
                "org": "National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China"
            },
            {
                "name": "Guan-Hua Du",
                "org": ""
            }
        ],
        "venue": "Vascular pharmacology",
        "year": 2007
    },
    "3MFQcgSc": {
        "id": "3MFQcgSc",
        "title": "Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects.",
        "abstract": "Decoctions prepared from the roots of Astragali Radix are known as \"Huangqi\" and are widely used in traditional Chinese medicine for treatment of viral and bacterial infections, inflammation, as well as cancer. Astragaloside IV (AS-IV), one of the major compounds from the aqueous extract of Astragalus membranaceus, is a cycloartane-type triterpene glycoside chemical. To date, many studies in cellular and animal models have demonstrated that AS-IV possesses potent protective effects in cardiovascular, lung, kidney and brain. Based on studies over the past several decades, this review systematically summarizes the pharmacological effects, pharmacokinetics and the toxicity of AS-IV. We analyze in detail the pharmacological effects of AS-IV on neuroprotection, liver protection, anti-cancer and anti-diabetes, attributable to its antioxidant, anti-inflammatory, anti-apoptotic properties, and the roles in enhancement of immunity, attenuation of the migration and invasion of cancer cells and improvement of chemosensitivity of chemotherapy drugs. In addition, the latest developments in the combination of AS-IV and other active ingredients of traditional Chinese medicine or chemical drugs are detailed. These pharmacological effects are associated with multiple signaling pathways, including the Raf-MEK-ERK pathway, EGFR-Nrf2 signaling pathway, Akt/PDE3B signaling pathway, AMPK signaling pathway, NF-κB signaling pathway, Nrf2 antioxidant signaling pathways, PI3K/Akt/mTOR signaling pathway, PKC-α-ERK1/2-NF-κB pathway, IL-11/STAT3 signaling pathway, Akt/GSK-3β/β-catenin pathway, JNK/c-Jun/AP-1 signaling pathway, PI3K/Akt/NF-κB pathway, miRNA-34a/LDHA pathway, Nox4/Smad2 pathway, JNK pathway and NF-kB/PPARγ pathway. This review will provide an overall understanding of the pharmacological functions of astragaloside IV on neuroprotection, liver protection, anti-cancer and anti-diabetes. In light of this, AS-IV will be a potent alternative therapeutic agent for treatment of the above mentioned diseases.",
        "keywords": [
            "Anti-apoptosis",
            "Anticancer",
            "Antioxidation",
            "Astragaloside IV",
            "Combined medication",
            "Glucose regulation",
            "Immunomodulatory effect",
            "Inhibition of inflammation",
            "Pharmacokinetics",
            "Toxicity"
        ],
        "authors": [
            {
                "name": "Jianqin Zhang",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, China."
            },
            {
                "name": "Chuxuan Wu",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, China."
            },
            {
                "name": "Li Gao",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, China."
            },
            {
                "name": "Guanhua Du",
                "org": "Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, P. R. China."
            },
            {
                "name": "Xuemei Qin",
                "org": "Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, China. Electronic address: qinxm@sxu.edu.cn."
            }
        ],
        "venue": "Advances in pharmacology (San Diego, Calif.)",
        "year": 2020
    },
    "VMYs96sn": {
        "id": "VMYs96sn",
        "title": "Corrigendum to “Genomic characteristics of a novel reovirus from Muscovy duckling in China” (Vet. Microbiol. 168 (2014) 261–271)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tao yun",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "zheng ni",
                "org": ""
            },
            {
                "name": "w ye",
                "org": ""
            },
            {
                "name": "liu chen",
                "org": ""
            },
            {
                "name": "jionggang hua",
                "org": ""
            },
            {
                "name": "cun zhang",
                "org": ""
            }
        ],
        "venue": "Veterinary Microbiology",
        "year": 2014
    },
    "YT4XzThC": {
        "id": "YT4XzThC",
        "title": "Construction and identification of eukaryotic vector plasmid of the infectious clone of rabbit hemorrhagic disease virus",
        "abstract": "【Objective】 The study was done to construct a research platform which is easy to operate the infectious clone of rabbit hemorrhagic disease virus(RHDV).【Method】 On the basis of pre-built infectious clone of RHDV,the full-length cDNA was divided into three fragments using the restriction endonuclease.The three fragments were ligated to the pcDNA3.1(+) plasmid in proper order in order to construct the eukaryotic vector of the infectious clone of RHDV.Then,the plasmid was transcripted into BHK-21 cells,the virus was collected and passed on for three generations.Next,the transfected BHK-21 cells which had the significant CPE were detected by RT-PCR.【Result】 The new vector was successfully constructed.The significant CPE of transfected BHK-21 cells and RT-PCR amplification indicated that the cDNA clones were rescued successfully in BHK-21 cells.【Conclusion】 The pcDNA3.1(+) eukaryotic expression vector can rescue the infectious RHDV easily.",
        "keywords": [
            "bhk-21 cell",
            "pcdna3.1(+)",
            "infectious clone of rabbit hemorrhagic disease virus(rhdv)",
            "dna cloning",
            "transfection"
        ],
        "authors": [
            {
                "name": "ZHAO Wei",
                "org": " College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": " Research Institute of Virology&Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China; Shanghai Veterinary Research Institute,The Chinese Academy of Agriculature Sciences,Shanghai ,China"
            },
            {
                "name": "NI Zheng",
                "org": " Research Institute of Virology&Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YUN Tao",
                "org": " Research Institute of Virology&Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "CHEN Liu",
                "org": " Research Institute of Virology&Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YU Bin",
                "org": " Research Institute of Virology&Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "ZHANG Miao-tao",
                "org": " College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2009
    },
    "S3RARClD": {
        "id": "S3RARClD",
        "title": "Preparation and identification of monoclonal antibodies against VP60 of RHDV",
        "abstract": "BALB/c mice were immunized with the recombinated capsid protein(VP60) of Rabit hemorrhagic disease virus(RHDV),and anti-VP60 mAb was prepared by using hybridoma techonology.The specificity of mAbs(AE11 and AH4) was characterized by Western-blot and indirect enzyme linked immunosorbent assay(ELISA).The results indicated that the mAbs was able to recognize the recombinated protein(rVP60) and the natural viral protein.However,the result of IFA indicated that only AE11 could react to RHDV,and the infected cells were stained clearly.The mAbs against VP60 were prepared successfully,which provides valuable reagent for developing the diagnosis reagent and studies on RHDV.",
        "keywords": [
            "capsid protein",
            "rabit hemorrhagic disease virus",
            "monoclonal antibody"
        ],
        "authors": [
            {
                "name": "WEI Wei",
                "org": "College of Veterinary Medicine,Gansu Agricultural University,Lanzhou ,China;Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "NI Zheng",
                "org": "Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "CHEN Liu",
                "org": "Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "YUN Tao",
                "org": "Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": "Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "WU Run",
                "org": "College of Veterinary Medicine,Gansu Agricultural University,Lanzhou ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Key Laboratory of Virology and Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Gansu Agricultural University",
        "year": 2009
    },
    "wM8dXlKT": {
        "id": "wM8dXlKT",
        "title": "Expression and localization analysis of VP60 protein of Rabbit hemorrhagic disease virus in insect cells-baculovirus expression system",
        "abstract": "A recombinant baculovirus expressing VP60 of Rabbit hemorrhagic disease virus (RHDV) was constructed with bac-to-bac baculovirus expression system to study the expression and intracellular localization of the structural protein VP60 of RHDV in Sf9 cells.The results of indirect immnuofluorescence assay (IFA) and Western blot analysis showed that the proteins were successfully expressed in Sf9 cells.The results of electron micrographs showed that there were some virus-like particles (VLPs) formed in Sf9 cells,and further results of confocal microscopy indicated that VP60 proteins were localized at the cellular membrane of Sf9 cells.",
        "keywords": [
            "Rabbit hemorrhagic disease virus",
            "intracellular localization",
            "structural protein",
            "insect cells-baculovirus expression system"
        ],
        "authors": [
            {
                "name": "CHEN Liu",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "YUN Tao",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "NI Zheng",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "SONG Yi",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China;College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua ,China"
            }
        ],
        "venue": "Acta Agriculturae Zhejiangensis",
        "year": 2010
    },
    "8yIx6z9h": {
        "id": "8yIx6z9h",
        "title": "Complete genomic sequence of goose-origin reovirus from China.",
        "abstract": "We report the full-genome sequence of a goose-origin reovirus (GRV) strain 03G from Zhejiang Province, China. This is the first report of the complete genomic sequence (segments 1 to 10) of GRV. Phylogenetic analyses of the sequence suggest that GRV 03G represents a new species distinct from other established species within the avian reovirus (ARV) group of orthoreoviruses.",
        "keywords": [
            "biomedical research",
            "bioinformatics",
            "phylogeny",
            "china"
        ],
        "authors": [
            {
                "name": "Tao Yun",
                "org": "Institute of Animal Husbandry and Veterinary Medicine, Zhejiang Academy of Agricultural Sciences, Hangzhou, China."
            },
            {
                "name": "Weicheng Ye",
                "org": ""
            },
            {
                "name": "Zheng Ni",
                "org": ""
            },
            {
                "name": "Liu Chen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Jionggang Hua",
                "org": ""
            },
            {
                "name": "Yan Zhang",
                "org": ""
            },
            {
                "name": "Cun Zhang",
                "org": ""
            }
        ],
        "venue": "Journal of virology",
        "year": 2012
    },
    "cBolVXMW": {
        "id": "cBolVXMW",
        "title": "Expression of E~(rns) Protein of Classical Swine Fever Virus with Fluorescent Label in Baculovirus Expression System",
        "abstract": "To obtain labeled Erns protein of classical swine fever virus,the coding region of Erns and green fluorescent protein(GFP)was fused by genetic engineering technique,and expressed in Sf9 cells according to the manual of Bac-to-Bac baculovirus expression system.The results of Western Blot analysis and fluorescence microscopy show that the fused proteins were successfully expressed with spontaneous green fluorescent.The established method of obtaining the labeled protein will be helpful for further exploring the structure and function of Erns protein.",
        "keywords": [
            "Bac-to-Bac baculovirus expression system",
            "Green fluorescent protein",
            "Erns",
            "Classical swine fever virus"
        ],
        "authors": [
            {
                "name": "CHEN Liu",
                "org": "Institute of Virology & Biotechnology,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Virology & Biotechnology,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "YUN Tao",
                "org": "Institute of Virology & Biotechnology,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "NI Zheng",
                "org": "Institute of Virology & Biotechnology,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": "Institute of Virology & Biotechnology,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            },
            {
                "name": "LI Shuang-mao",
                "org": "Institute of Virology & Biotechnology,Zhejiang Academy of Agriculture Sciences,Hangzhou ,China"
            }
        ],
        "venue": "Acta Agriculturae Boreali-Sinica",
        "year": 2011
    },
    "QPBef0Wb": {
        "id": "QPBef0Wb",
        "title": "CONSTRUCTION OF THE LENGTH cDNA LIBRARY OF RK13 CELLS",
        "abstract": "The full length cDNA library of rabbit kidney epithelial(RK-13) cells was constructed to identify RHDV receptors.Total mRNAs were isolated and purified from RK-13 cell and then the first strand cDNAs were synthesized by reverse transcription(RT) with RT primer(CDSIII) and the double-stranded cDNAs were amplified by long-distance-PCR.Subsequently,the ds cDNAs were inserted into the eukaryotic expression vector(pEXP-Lib) and transformed into E.coli cells(DH5α).The results showed that the cDNA library contained 2.55×105 clone with averaged inserts about 1.0 Kb.",
        "keywords": [
            "RK13",
            "cDNA library",
            "storage capacity",
            "Rabbit kidney epithelial cell"
        ],
        "authors": [
            {
                "name": "SONG Yi",
                "org": "Zhejiang Normal University,Jinhua ,China"
            },
            {
                "name": "CHEN Liu",
                "org": "Virology and Biotechnology Research Institute,Zhejiang Academy of Agriculture Sciences,Hangzhou,China"
            },
            {
                "name": "YU Bin",
                "org": "Virology and Biotechnology Research Institute,Zhejiang Academy of Agriculture Sciences,Hangzhou,China"
            },
            {
                "name": "NI Zheng",
                "org": "Virology and Biotechnology Research Institute,Zhejiang Academy of Agriculture Sciences,Hangzhou,China"
            },
            {
                "name": "YUN Tao",
                "org": "Virology and Biotechnology Research Institute,Zhejiang Academy of Agriculture Sciences,Hangzhou,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Shanghai Veterinary Research Institute,CAAS,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Animal Infectious Diseases",
        "year": 2010
    },
    "Jr3TtqKU": {
        "id": "Jr3TtqKU",
        "title": "Construction and immunogenicity of recombinant adenovirus co-expressing the GP5 and M protein of porcine reproduction and respriratory syndrome virus in mice]",
        "abstract": "FMDV 2A peptide was introduced as a linker between GP5 and M protein of porcine reproduction and respiratory syndrome virus (PRRSV) to allow automatic self-cleavage the polyproteins. This strategy simultaneously displayed the neutralizing action of GP5 protein and cell-mediated immunity of M protein. We put them into the expression cassette of adenovirus vector. The results of RT-PCR, IFA and Western blotting showed that GP5 and M protein were not only expressed correctly, but also self-cleavaged and assemble heterodimers formation. To detect the advantages of rAd-GP5-2A-M, we also constructed some other recombinant adenoviruses (rAd-GP5, rAd-M and rAd-GP5-M) as control. After inoculated subcutaneously into BALB/c mice, the four recombinant adenoviruses can induce PRRSV-specific antibodies and cell-mediated immune response, but the level of humoral and cell-mediated immune response against PRRSV induced by rAd-GP5-2A-M is the strongest among the four recombinant adenoviruses. All of these suggested that it is possible to develop one multi-gene engineering vaccine utilizing FMDV 2A peptide, and also provided a novel strategy for developing other viral disease vaccine.",
        "keywords": [
            "foot-and-mouth disease virus",
            "porcine reproduction and respiratory syndrome virus",
            "2a peptide",
            "recombinant adenovirus"
        ],
        "authors": [
            {
                "name": "Tao Yun",
                "org": " Research Institute of Virology & Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China; College of Veterinary Medicine,Northwest Agricultrue & Forest University,Yangling ,China"
            },
            {
                "name": "Zheng Ni",
                "org": " Research Institute of Virology & Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Bin Yu",
                "org": " Research Institute of Virology & Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Liu Chen",
                "org": " Research Institute of Virology & Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Jionggang Hua",
                "org": " Research Institute of Virology & Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Genrong Wang",
                "org": " Jiaxing Husbandry and Veterinary Station,Jiaxing ,China"
            },
            {
                "name": "Guangqing Liu",
                "org": " Research Institute of Virology & Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            }
        ],
        "venue": "Sheng wu gong cheng xue bao = Chinese journal of biotechnology",
        "year": 2009
    },
    "y2sN1ajw": {
        "id": "y2sN1ajw",
        "title": "Molecular Characteristics of Complete Genome of a Porcine reproductive and respiratory syndrome virus NB/04 Strain",
        "abstract": "",
        "keywords": [
            "Porcine respiratory and reproductive syndrome virus",
            "NB/04",
            "genome"
        ],
        "authors": [
            {
                "name": "YUN Tao",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            },
            {
                "name": "WANG Gen-rong",
                "org": "Jiaxing Husbandry and Veterinary Station, Jiaxing , China"
            },
            {
                "name": "NI Zheng",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            },
            {
                "name": "YU Bin",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            },
            {
                "name": "LIANG Hua-li",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            },
            {
                "name": "LI Shuang-mao",
                "org": "Research Institute of Virology & Biotechnology of Agriculture Ministry, Zhejiang Academy of Agriculture Sciences, Hangzhou , China"
            }
        ],
        "venue": "Journal of Agricultural Biotechnology",
        "year": 2008
    },
    "Q8F9SWwz": {
        "id": "Q8F9SWwz",
        "title": "Optimized Expression of Duck Tembusu Virus E Gene Delivered by a Vectored Duck Enteritis Virus In Vitro.",
        "abstract": "In our previous study, a recombinant duck enteritis virus (DEV) delivering codon-optimized E gene (named as E-ch) of duck Tembusu virus (DTMUV) optimized referring to chicken’s codon bias has been obtained based on the infectious bacterial artificial chromosome (BAC) clone of duck enteritis virus vaccine strain pDEV-EF1, but the expression level of E-ch in recombinant virus rDEV-E-ch-infected cells was very low. To optimize DTMUV E gene expression delivered by the vectored DEV, different forms of E gene (collectively called EG) including origin E gene (E-ori), truncated E451-ori gene, codon-optimized E-dk gene optimized referring to duck’s codon bias, as well as the truncated E451-ch and E451-dk, Etpa-ori and Etpa-451-ori, which contain prefixing chick TPA signal peptide genes, were cloned into transfer vector pEP-BGH-end, and several recombinant plasmids pEP-BGH-EG were constructed. Then the expression cassettes pCMV-EG-polyABGH amplified from pEP-BGH-EG by PCR were inserted into US7/US8 gene intergenic region of pDEV-EF1 by two-step Red/ET recombination, 7 strain recombinant mutated BAC clones pDEV-EG carrying different E genes were constructed. Next, the recombinant viruses rDEV-EG were reconstituted from chicken embryo fibroblasts (CEFs) by calcium phosphate precipitation. Western blot analysis showed that E or E451 protein is expressed in rDEV-E-ori, rDEV-E-ch, rDEV-Etpa-ori, rDEV-E451-ori, rDEV-E451-dk, and rDEV-E451-ch-infected CEFs, and protein expression level in rDEV-E451-dk-infected CEFs is the highest. These studies have laid a foundation for developing bivalent vaccine controlling DEV and DTMUV infection.",
        "keywords": [
            "Duck Tembusu virus",
            " Duck enteritis virus",
            " Vectored vaccine",
            " Optimized expression",
            " E antigen"
        ],
        "authors": [
            {
                "name": "Liu Chen",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            },
            {
                "name": "Jonggang Hua",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            },
            {
                "name": "Zheng Ni",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            },
            {
                "name": "Weicheng Ye",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            },
            {
                "name": "Tao Yun",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            },
            {
                "name": "Cun Zhang",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agriculture Sciences, Hangzhou, China"
            }
        ],
        "venue": "Molecular Biotechnology",
        "year": 2019
    },
    "R8aX67lV": {
        "id": "R8aX67lV",
        "title": "Construction and analysis of full length cDNA of Duck Virus Hepatitis Type Ⅰ",
        "abstract": "【Objective】 The study was to develop a reverse genetics system of Duck Virus Hepatitis Type Ⅰ(DHV-Ⅰ).【Method】 Five pairs of oligonucleotides were designed based on the full length genomic sequence of DHV ZJ-V strain.Using RT-PCR technique,five overlapping cDNA fragments,designated as A,B,C,D and E were amplified respectively.And D and E fragments were fused by PCR designated as ED.Using pBluescript Ⅱ KS(+) as a plasmid vector,the full-length cDNA clone pBLDHV of DHV ZJ-V strain was obtained by connecting the four cDNA fragments utilizing single restriction endonuclase site.A ApaⅠsite and a SP6 promoter were introduced immediately upstream of 5′ end,while a NruⅠ Site was engineered down stream of 3′ end of DHV poly(A) tail(containing 20 As).【Result】 The results of sequencing and analysis showed that there were 99.9% identical between the construction of the full-length cDNA sequences and cDNA sequences of DHV-Ⅰ ZJ-V strain.The only differences in sequence were at 6 positions,none of which affected the amino acid sequence.【Conclusion】 Successful construction of full-length cDNA clone of DHV-Ⅰ ZJ-V strain lays a foundation for rescuing DHV effectively and enables further research of DHV at molecular level.",
        "keywords": [
            "Duck virus hepatitis(DHV)",
            "full length cDNA clone",
            "infectious cDNA clone"
        ],
        "authors": [
            {
                "name": "YUN Tao",
                "org": " College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi ,China; Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "NI Zheng",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YU Bin",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "CHEN Liu",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "LI Shuang-mao",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "ZHANG Yan-ming",
                "org": " College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2010
    },
    "YKD6ArSp": {
        "id": "YKD6ArSp",
        "title": "Development and application of an indirect ELISA for the detection of antibodies to novel duck reovirus.",
        "abstract": "A novel duck reovirus (N-DRV) disease emerged in China in 2000 and it has become an epidemic genotype. A test for detection of virus-specific antibodies in serum samples would be useful for epidemiological investigations. Currently, Currently, serological assays for N-DRV diagnosis are not available. A test for detection of virus-specific antibodies in serum samples would be useful for epidemiological investigations. In this study, a highly sensitive and specific indirect enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to N-DRV was developed. The outer capsid (σC) of N-DRV was cloned and expressed in Escherichia coli as a coating antigen. The antigen concentration and serum dilution were optimized using a checkerboard titration. Furthermore, the specificity of σC-ELISA assay was confirmed by cross checking with other duck viral pathogens. In comparison with the western blot, the sensitivity and specificity of the σC-ELISA was 92.6% and 88.9%, respectively, and agreement of two tests was excellent with κ value of 0.786 (p<0.05). A serological survey was performed using the assay on serum samples from different age and species of duck flocks in the Zhejiang and Jiangsu Province, China. The seropositive rate of the 1209 serum samples was 57.7%. In conclusion, the developed σC-ELISA assay is a very specific and sensitive test that will be useful for large-scale serological survey in N-DRV infection and monitoring antibodies titers against N-DRV.",
        "keywords": [
            "indirect elisa",
            "novel duck reovirus (n-drv)",
            "serological survey",
            "σc protein"
        ],
        "authors": [
            {
                "name": "Tao Yun",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            },
            {
                "name": "Haipeng Chen",
                "org": "College of Animal Science and Veterinary Medicine, Shandong Agricultural University, Tai'an 271018, China."
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            },
            {
                "name": "Cun Zhang",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            },
            {
                "name": "Liu Chen",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            },
            {
                "name": "Zheng Ni",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            },
            {
                "name": "Jionggang Hua",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            },
            {
                "name": "Weicheng Ye",
                "org": "Institute of Animal Husbandry and Veterinary Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China."
            }
        ],
        "venue": "Journal of virological methods",
        "year": 2015
    },
    "WalvCCfw": {
        "id": "WalvCCfw",
        "title": "Development of a RT-PCR method for detecting duck hepatitis virus type Ⅰ",
        "abstract": "According to the results of DNA sequencing of duck hepatitis virus(DHV-Ⅰ) ZJ/06 virulent strain,a pair of specific primers which could amplify 238 bp fragment in gene region of genome 3D were designed and developed,a RT-PCR method detecting DHV-Ⅰ was developed successfully,and the specific and susceptibility of DHV-Ⅰ were determined.A specific 238 bp fragment could be amplified from virulent strains and clinic samples of DHV-Ⅰ by RT-PCR method,but no bands were amplified from four kinds of normal duck diseases: duck plague virus(DPV),duck egg drop syndrome virus(DEDSV),duck paramyxovirus(DPV) and Riemerella anatipestifer from duck(DRA).Some clinical samples of DHV-Ⅰ were isolated and identified using BHK-21 cell and SPF chicken embryo,respectively.The results showed that the method of RT-PCR setup for detecting DHV-Ⅰ had the character of fast,specific and sensitive.",
        "keywords": [
            "detection method",
            "Duck hepatitis virus",
            "RT-PCR"
        ],
        "authors": [
            {
                "name": "HUA Jiong-gang",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "WANG Fei",
                "org": "College of Animal Science and Technology,Anhui Agriculture University,Hefei,Anhui ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "NI Zheng",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "YUN Tao",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "LIANG Hua-li",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "LI Shuang-mao",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            }
        ],
        "venue": "Acta Agriculturae Zhejiangensis",
        "year": 2007
    },
    "qh5vuXPp": {
        "id": "qh5vuXPp",
        "title": "Short Communication Minor structural protein VP2 in rabbit hemorrhagic disease virus downregulates the expression of the viral capsid protein VP60",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "liu chen",
                "org": ""
            },
            {
                "name": "guangqing liu",
                "org": ""
            },
            {
                "name": "zheng ni",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "tao yun",
                "org": ""
            },
            {
                "name": "yi song",
                "org": ""
            },
            {
                "name": "jionggang hua",
                "org": ""
            },
            {
                "name": "shuangmao li",
                "org": ""
            },
            {
                "name": "jianping chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "keiWCbDc": {
        "id": "keiWCbDc",
        "title": "Sequencing and analyzing of the capsid protein gene of seven rabbit Haemorrhagic disease virus(RHDV) isolated from Zhejiang",
        "abstract": "【Objective】In order to study the genetic variation of rabbit haemorrhagic disease virus(RHDV),and to provide some useful data to make efficient controlling measures.【Method】The capsid protein gene(VP60) of seven RHDV isolated from Zhejiang were sequenced.【Result】The nucleotide sequence of the gene was 1 740nt in length,encoding a protein of 580aa.The VP60 gene of the seven strains shared high sequence homology(from 94.0% to 99.8%) with those of the reference strains;all the RHDV isolates could be divided into two genetic groups(GⅠ and GⅡ),which can be divided into two subgroups(A and B;C and D),respectively.Most of Chinese strains located in C subgroup,and showed closer genetic relation with some European strains.Besides,the phylogenetic tree also indicated that RHDV have evolved into different extents.【Conclusion】RHDV may exist genetic variation during its epidemic and evolution.",
        "keywords": [
            "Rabbit haemorrhagic disease virus",
            "capsid protein gene",
            "phylogenetic tree"
        ],
        "authors": [
            {
                "name": "ZHU Jin-mei",
                "org": " College of Veterinary Medicine,Northwest A & F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": " Research Institute of Virology & Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "NI Zheng",
                "org": " Research Institute of Virology & Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YUN Tao",
                "org": " Research Institute of Virology & Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YU Bin",
                "org": " Research Institute of Virology & Biotechnology Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "ZHANG Miao-tao",
                "org": " College of Veterinary Medicine,Northwest A & F University,Yangling,Shaanxi ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2008
    },
    "IfsTw1UG": {
        "id": "IfsTw1UG",
        "title": "Complete genome sequence of a novel flavivirus, duck tembusu virus, isolated from ducks and geese in china.",
        "abstract": "Duck tembusu virus (DTMUV) is an emerging agent that causes a severe disease in ducks. We report herein the first complete genome sequences of duck tembusu virus strains YY5, ZJ-407, and GH-2, isolated from Shaoxing ducks, breeder ducks, and geese, respectively, in China. The genomes of YY5, ZJ-407, and GH-2 are all 10,990 nucleotides (nt) in length and encode a putative polyprotein of 3,426 amino acids. It is flanked by a 5' and a 3' noncoding region (NCR) of 94 and 618 nt, respectively. Knowledge of the whole sequence of DTMUV will be useful for further studies of the mechanisms of virus replication and pathogenesis.",
        "keywords": [],
        "authors": [
            {
                "name": "Tao Yun",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Dabing Zhang",
                "org": "China Agricultural University(China Agricultural University),Beijing,China"
            },
            {
                "name": "Xuejun Ma",
                "org": "Chinese Center for Disease Control and Prevention(^ Chinese Center for Disease Control and Prevention),Beijing,China"
            },
            {
                "name": "Zhenzhen Cao",
                "org": "China Agricultural University(China Agricultural University),Beijing,China"
            },
            {
                "name": "Liu Chen",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Zheng Ni",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Weicheng Ye",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Jionggang Hua",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Yan Zhang",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Cun Zhang",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            }
        ],
        "venue": "Journal of virology",
        "year": 2012
    },
    "wl58MUE6": {
        "id": "wl58MUE6",
        "title": "Construction and characterization of a recombinant pseudorabies virus expressing VP2 of porcine parvovirus and Cap of porcine circovirus type 2",
        "abstract": "To develop porcine pseudorabies virus(PRV),porcine parvovirus(PPV) and porcine circovirus type 2(PCV2) trivalent vaccine,the recombinant plasmid pEP-V2C-in was constructed by inserting VP2-2A-Cap(V2C) gene,which consisted of the CDS of PPV VP2 and PCV2 Cap gene linked with 2A gene of foot and mouth disease virus(FMDV),into expression vector pEP-CMV-in.The BAC clones of pPRV-V2C-ΔgE and pPRV-ΔgE were generated by twice Red/ET recombinations in E.coli.Then the recombinant virus of rPRV-V2C-ΔgE and rPRV-ΔgE were rescued from BHK-21 cells transfected with the pPRV-V2C-ΔgE and pPRV-ΔgE by calcium phosphate precipitation,respectively.Western blot assay showed that PPV VP2 and PCV2 Cap proteins were expressed in rPRV-V2C-ΔgE virus-infected BHK-21 cells with the molecular mass of 64 ku and 28 ku respectively,which demonstrates that the VP2-2A-Cap fused protein were cleaved by FMDA 2A.Furthermore,the results of growth kinetics and plaque formation sizes showed that insertion of the foreign genes had no influence on the propagation of rPRV-Bac-EF1 in BHK-21 cells.These studies have laid a foundation for developing PRV based vector vaccine expressing PPV VP2 and PCV2 Cap.",
        "keywords": [
            "porcine circovirus type 2",
            "porcine parvovirus",
            "pseudorabies virus infectious clone",
            "bacteria artificial chromosome"
        ],
        "authors": [
            {
                "name": "DENG Xiao-hui",
                "org": "College of Animal Science,Shandong Agricultural University,Tai'an ,China;Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "CHEN Liu",
                "org": "Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "YE Wei-cheng",
                "org": "Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "LI Jun-xing",
                "org": "Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "CUI Shang-jin",
                "org": "Division of Swine Infectious Disease,State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "YUN Tao",
                "org": "Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "CUI Yan-shun",
                "org": "College of Animal Science,Shandong Agricultural University,Tai'an ,China"
            },
            {
                "name": "SUN Yuan",
                "org": "Division of Swine Infectious Disease,State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "QIU Hua-ji",
                "org": "Division of Swine Infectious Disease,State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "ZHANG Shuai",
                "org": "College of Animal Science,Shandong Agricultural University,Tai'an ,China;Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "ZHANG Cun",
                "org": "Institute of Animal Husbandry and Veterinary Sciences,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Preventive Veterinary Medicine",
        "year": 2012
    },
    "qw3pbCbQ": {
        "id": "qw3pbCbQ",
        "title": "INTRACELLULAR LOCALIZATION OF THE MINOR STRUCTURAL PROTEIN(VP2) OF RABBIT HEMORRHAGIC DISEASE VIRUS(RHDV)",
        "abstract": "Virus protein VP2 is a minor structural protein of rabbit hemorrhagic disease virus(RHDV).The objective of the present study was to study the expression and intracellular localization of VP2 in eukaryotic cells by fusion with enhanced green fluorescent protein(EGFP).The GST-VP2 fusion protein expressed in E.coli was purified and inoculated into mice.The polyclonal murine antibody was prepared and the specificity to VP2 was determined.To explore the intracellular localization of VP2,the recombinant plasmid(pEGFP-VP2)fused with EGFP was constructed and transfected into BHK-21 cells.The expression of EGFP-VP2 protein was detected by Western blot assay.The intracellular localization of VP2 was observed under fluorescence microscope.Besides,the localization of VP2 was further examined by staining cells with DAPI.The recombinant plasmids were constructed and the fusion proteins were expressed in BHK-21 cells.The VP2 and EGFP were co-localized in BHK-21cells and VP2 was primarily localized in cytoplasm as determined by using indirect immunofluorescence assay(IFA) and DAPI staining.The construct of fusion expression vector of pEGFP-VP2 and expression in eukaryotic cells have laid the foundation for studying the biological function of VP2.",
        "keywords": [
            "Rabbit hemorrhagic disease virus(RHDV)",
            "intracellular localization",
            "minor structural protein",
            "VP2"
        ],
        "authors": [
            {
                "name": "CHEN Liu",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            },
            {
                "name": "NI Zheng",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            },
            {
                "name": "YU Bin",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            },
            {
                "name": "YUN Tao",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            },
            {
                "name": "LI Shuang-mao",
                "org": "Key laboratory of Virology & Biotechnology of Ministry of Agriculture,Zhejiang Academy ofAgriculture Sciences,Hangzhou,,China"
            }
        ],
        "venue": "Chinese Journal of Animal Infectious Diseases",
        "year": 2009
    },
    "YsLGGD11": {
        "id": "YsLGGD11",
        "title": "Progress on Viral Receptors of Caliciviruses",
        "abstract": "Caliciviruses are a diverse virus family with a wide range of host and tissue tropisms.Over recent years much progress has been made in identifying receptors of caliciviruses.The receptors of caliciviruses could be divided into two groups.One is carbohydrate,including histo-blood group antigens(HBGAs),sialic acid,heparan sulfate;another is cellular protein,such as junctional adhension molecular A(JAM-A),an unkown 105 ku membrane protein.Furthermore,many researches have also revealed the molecular basis of receptor recognition by caliciviruses.These will help to understand the virus-host interactions and will further be helpful for designing and developing anti-viral drugs and vaccines to control and prevent calicivirus infection and illness.",
        "keywords": [
            "carbohydrate",
            "receptor",
            "cellular protein",
            "Caliciviruses"
        ],
        "authors": [
            {
                "name": "CHEN Liu",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": "Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai,,China"
            },
            {
                "name": "SONG Yi",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China;College of Chemistry and Life Sciences,Zhejiang Normal University,Jinhua,Zhejiang,,China"
            },
            {
                "name": "NI Zheng",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China"
            },
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China"
            },
            {
                "name": "LI Shuang-mao",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China"
            },
            {
                "name": "YUN Tao",
                "org": "Key Laboratory of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang,,China"
            }
        ],
        "venue": "Progress in Veterinary Medicine",
        "year": 2010
    },
    "4ffvdYAe": {
        "id": "4ffvdYAe",
        "title": "Construction and identification of recombinant adenovirus containing FMDV 2A sequence,expressing GP5 and M protein of porcine reproduction and respiratory syndrome virus",
        "abstract": "【Objective】 Based on the self-cleaving ability of foot-and-mouth disease virus(FMDV) 2A proteinase,we ligated GP5 and M coding region of porcine reproduction and respiratory syndrome virus(PRRSV) with the short peptide,and put them in the expression box of adenovirus vector.Through this new strategy,GP5 and M not only can be expressed at the same time,but also can be cleaved into two independent proteins,which will be helpful to play the neutralizing action of GP5 protein and the cell-mediated immunity of M protein.【Method】 The recombinant adenovirus(rAd-GP5-2A-M) was identified by RT-PCR,IFA and Western blot methods etc.【Result】 This kind of recombinant adenovirus(rAd-GP5-2A-M)was constructed successfully.【Conclusion】 It showed that it is possible to develop one multi-gene engineering vaccine against PRRS utilizing FMDV 2A proteinase,which also can provide a novel strategy for developing other viral disease vaccine.",
        "keywords": [
            "foot-and-mouth disease virus",
            "porcine reproduction and respiratory syndrome virus",
            "2a proteinase",
            "genetic engineering"
        ],
        "authors": [
            {
                "name": "YUN Tao",
                "org": " College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi ,China; Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "NI Zheng",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YU Bin",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "CHEN Liu",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "HUA Jiong-gang",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "WANG Gen-rong",
                "org": " Jiaxing Husbandry and Veterinary Station,Jiaxing,Zhejiang ,China"
            },
            {
                "name": "ZHANG Yan-ming",
                "org": " College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": " Research Institute of Virology & Biotechnology of Agriculture Ministry,Zhejiang Academy of Agriculture Sciences,Hangzhou,Zhejiang ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2009
    },
    "HJyLY6qy": {
        "id": "HJyLY6qy",
        "title": "Isolation and genomic characterization of a classical Muscovy duck reovirus isolated in Zhejiang, China.",
        "abstract": "A classical Muscovy reovirus was isolated from a sick Muscovy duck with white necrotic foci in its liver in Zhejiang, China, in 2000. This classical reovirus was propagated in a chicken fibroblast cell line (DF-1) with obvious cytopathic effects. Its genome was 22,967 bp in length, with approximately 51.41% G+C content and 10 dsRNA segments encoding 11 proteins, which formed a 3/3/4 electrophoretic PAGE profile pattern. The length of the genomic segments was similar to those of avian orthoreoviruses (ARV and N-MDRV), ranging from 3959 nt (L1) to 1191nt (S4). All of the segments have the conserved terminal sequences 5'-GCUUUU--UUCAUC-3', and with the exception of the S4 segment, all the genome segments apparently encode one single primary translation product. The genome analysis revealed that the S4 segment of classical MDRV is a bicistronic gene, encoding the overlapping ORFs for p10 and σC but distinct from ARV and N-MDRV/N-GRV, which codes for p10, p18 and σC via the tricistronic S1 segment. A comparative sequence analysis provided evidence indicating extensive sequence divergence between classical MDRV and other avian orthoreoviruses. A phylogenetic analysis based on the RNA-dependent RNA polymerase (RdRp) and the major outer capsid proteins σC was performed. Members of the DRVs in the Avian orthoreovirus species were clustered into two genetic groups (classical MDRV and N-MDRV genotype), and the classical MDRV isolates formed distinct lineages (China and Europe lineages), suggesting that the classical MDRVs isolated in restricted geographical region are evolving by different and independent pathways.",
        "keywords": [
            "genome sequence",
            "phylogenetic analysis",
            "classical muscovy duck reovirus",
            "avian orthoreovirus"
        ],
        "authors": [
            {
                "name": "Tao Yun",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Zheng Ni",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Weicheng Ye",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Liu Chen",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Jionggang Hua",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Cun Zhang",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            }
        ],
        "venue": "Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases",
        "year": 2013
    },
    "FZQRFlh6": {
        "id": "FZQRFlh6",
        "title": "Construction of a full-length infectious bacterial artificial chromosome clone of duck enteritis virus vaccine strain.",
        "abstract": "Duck enteritis virus (DEV) is the causative agent of duck viral enteritis, which causes an acute, contagious and lethal disease of many species of waterfowl within the order Anseriformes. In recent years, two laboratories have reported on the successful construction of DEV infectious clones in viral vectors to express exogenous genes. The clones obtained were either created with deletion of viral genes and based on highly virulent strains or were constructed using a traditional overlapping fosmid DNA system. Here, we report the construction of a full-length infectious clone of DEV vaccine strain that was cloned into a bacterial artificial chromosome (BAC).A mini-F vector as a BAC that allows the maintenance of large circular DNA in E. coli was introduced into the intergenic region between UL15B and UL18 of a DEV vaccine strain by homologous recombination in chicken embryoblasts (CEFs). Then, the full-length DEV clone pDEV-vac was obtained by electroporating circular viral replication intermediates containing the mini-F sequence into E. coli DH10B and identified by enzyme digestion and sequencing. The infectivity of the pDEV-vac was validated by DEV reconstitution from CEFs transfected with pDEV-vac. The reconstructed virus without mini-F vector sequence was also rescued by co-transfecting the Cre recombinase expression plasmid pCAGGS-NLS/Cre and pDEV-vac into CEF cultures. Finally, the in vitro growth properties and immunoprotection capacity in ducks of the reconstructed viruses were also determined and compared with the parental virus.The full genome of the DEV vaccine strain was successfully cloned into the BAC, and this BAC clone was infectious. The in vitro growth properties of these reconstructions were very similar to parental DEV, and ducks immunized with these viruses acquired protection against virulent DEV challenge.DEV vaccine virus was cloned as an infectious bacterial artificial chromosome maintaining full-length genome without any deletions or destruction of the viral coding sequence, and the viruses rescued from the DEV-BAC clone exhibited wild-type phenotypes both in vitro and in vivo. The generated infectious clone will greatly facilitate studies on the individual genes of DEV and applications in gene deletion or live vector vaccines.",
        "keywords": [
            "bacterial artificial chromosome",
            "duck enteritis virus",
            "infectious clone",
            "virology",
            "f factor",
            "escherichia coli",
            "chickens"
        ],
        "authors": [
            {
                "name": "Liu Chen",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Jionggang Hua",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Weicheng Ye",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Zheng Ni",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Tao Yun",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Xiaohui Deng",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            },
            {
                "name": "Cun Zhang",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences,Zhejiang Academy of Agricultural Science),Hangzhou,China"
            }
        ],
        "venue": "Virology journal",
        "year": 2013
    },
    "wxQNMcQt": {
        "id": "wxQNMcQt",
        "title": " Th1-biased immunoadjuvant effect of the recombinant B subunit of an Escherichia coli heat-labile enterotoxin on an inactivated PRRSV antigen via intranasal immunization in mice.",
        "abstract": "Porcine reproductive and respiratory syndrome (PRRS) is one of the major swine diseases responsible for a significant challenge in the global swine industry. The current PRRS inactivated vaccine only confers limited protection against PRRSV. Thus, using an appropriate adjuvant via a suitable administration route may help improve vaccine efficacy. In this study, the recombinant B subunit of the Escherichia coli heat-labile enterotoxin rLTB, was highly expressed in Pichia pastoris, through high-density fermentation. rLTB intranasal adjuvant properties were evaluated on an inactivated PRRS antigen in mice. Compared to the group immunized with solely PRRS antigen, a dose of 50 μg rLTB remarkably raised antigen-specific IgA antibodies at mucosal sites, and increased serum IgG antibodies, preferentially the IgG2a and IgG2b subclasses. Further, rLTB induced increases in Th1- (IFN-γ and IL-12) and Th17 (IL-6) cytokine profiles, but had little effect on Th2 cytokine profiles (IL-4 and IL-10). Moreover, there were no overt toxicities associated with intranasal rLTB administration. Our data provide evidence that the rLTB produced by P. pastoris fermentation portrays low toxicity, and its intranasal adjuvant effect involves immune system modulation to a Th1 profile.",
        "keywords": [
            "Th1",
            "intranasal adjuvant",
            "porcine reproductive and respiratory syndrome virus antigen (PRRSV)",
            "rLTB"
        ],
        "authors": [
            {
                "name": "Fei Su",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            },
            {
                "name": "Lihua Xu",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            },
            {
                "name": "Yin Xue",
                "org": "Zhejiang Center of Animal Disease Control."
            },
            {
                "name": "Junxing Li",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            },
            {
                "name": "Yuan Fu",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            },
            {
                "name": "Sai Wang",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            },
            {
                "name": "Xiufang Yuan",
                "org": "Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences."
            }
        ],
        "venue": "The Journal of veterinary medical science",
        "year": 2019
    },
    "UBzQhXg4": {
        "id": "UBzQhXg4",
        "title": "CONSTRUCTION AND IDENTIFICATION OF RABBIT HEMORRHAGIC DISEASE VIRUS MUTANT",
        "abstract": "In order to study relationship of rabbit hemorrhagic disease virus(RHDV)capsid protein and viral infection,a cDNA clone coding gene(5 325-6 931 nt) was constructed to express a truncated capsid protein(VP60).After in vitro transcription of synthetic RNA and transfection in RK-13 cells,virus infection and replication were examined.Results showed that the loss of 5 325-6 931 nt region had no significant impact on virus infection but reduced virus replication.This suggested that this region might be associated with viral replication.",
        "keywords": [
            "capsid protein",
            "Rabbit hemorrhagic disease virus(RHDV)",
            "mutant",
            "RK-13 cell"
        ],
        "authors": [
            {
                "name": "XIE Yu-zhu",
                "org": "Colleg e of Animal Science and Technology,Anhui Agriculture University,Hefe ,China"
            },
            {
                "name": "NI Zheng",
                "org": " Zhejiang Academy of Agriculture Sciences,HangZhou ,China"
            },
            {
                "name": "YUN Tao",
                "org": " Zhejiang Academy of Agriculture Sciences,HangZhou ,China"
            },
            {
                "name": "CHEN Liu",
                "org": " Zhejiang Academy of Agriculture Sciences,HangZhou ,China"
            },
            {
                "name": "YU Bin",
                "org": " Zhejiang Academy of Agriculture Sciences,HangZhou ,China"
            },
            {
                "name": "LIU Guang-qing",
                "org": " Shanghai Veterinary Research Institute,CAAS,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Animal Infectious Diseases",
        "year": 2010
    },
    "pgF5hEdw": {
        "id": "pgF5hEdw",
        "title": "Genomic characteristics of a novel reovirus from Muscovy duckling in China.",
        "abstract": "A new reovirus was isolated from a sick Muscovy duckling with hemorrhagic-necrotic lesions in the liver in Zhejiang, China in 2000 and was tentatively denoted a new type of Muscovy duck reovirus (N-MDRV ZJ00M). This reovirus was propagated in a chicken fibroblast cell line (DF-1) with obvious cytopathic effects. The reovirus's genome was 23,419 bp in length with an approximately 50% G+C content and 10 dsRNA segments encoding 12 proteins. The length of the genomic segments was similar to those of avian reoviruses (ARVs), which range from 3959 nt (L1) to 1191 nt (S4) in size. All of the segments have the conserved terminal sequences 5'-GCUUUUU…UUCAUC-3', and all of the genome segments, with the exception of S1, apparently encoded one single primary translation product. The genome analysis revealed that the S1 segment of N-MDRV is a tricistronic gene that encodes the overlapping ORFs for p10, p18, and σC. This finding is similar to that found for ARVs but distinct from that found for classical MDRV and GRV, which have a bicistronic S4 segment that encodes p10 and σC and do not encode p18. The amino acid (aa) alignments of the putative proteins encoded by the main ORF in each segment revealed a high similarity (14.1-100%) to the counterpart proteins encoded by other ARV species from the avian orthoreoviruses (e.g., ARV, classical MDRV and N-MDRV) in the Orthoreovirus genus, particularly with N-MDRV (94.6-100%). The phylogenetic analysis of the nucleotide sequences of all 10 genome segments revealed that N-MDRV ZJ00M is distinct from all other described reovirus species groups but is a separated from the ARV (including MDRV and GRV) species within orthoreovirus species group II and grouped into the classical MDRV and GRV genogroup with the N-MDRV isolates. The MDRV genogroup can be further divided into two genotype clusters. The morphological and pathological analyses and the genetic characterization of N-MDRV ZJ00M suggest that it belongs to genotype 2 (N-MDRV). In addition, the RT-PCR assays of DRV diseased duckling and gosling samples collected from different regions of China during 2000-2013 indicate that N-MDRV is currently the prevalent genotype in China.",
        "keywords": [
            "novel muscovy duck reovirus",
            "genotype",
            "rt-pcr assay",
            "sequence analysis"
        ],
        "authors": [
            {
                "name": "Tao Yun",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Zheng Ni",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Weicheng Ye",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Liu Chen",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Jionggang Hua",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            },
            {
                "name": "Cun Zhang",
                "org": "Zhejiang Academy of Agricultural Sciences(Zhejiang Academy of Agricultural Sciences),Hangzhou,China"
            }
        ],
        "venue": "Veterinary microbiology",
        "year": 2014
    },
    "AVGDuGPj": {
        "id": "AVGDuGPj",
        "title": "Studies on the apoptosis of RK13 cells induced by rabbit hemorrhagic disease virus]",
        "abstract": "The apoptosis of RK13 cells induced by RHDV was investigated with DAPI staining, DNA ladder, Caspase 3 activity and flow cytometry, etc. The results showed that nuclear staining of infected cells with DAPI showed gradually morphological changes of the nuclei. As shown in the paper, a canonic oligonucleosome-sized DNA ladder was observed in cells harvested at 24h, 48h and 72h post-infection, confirming that DNA fragmentation was induced by RHDV infection. The results of flow cytometry showed that about 63% of cells were in apoptosis at 48h post-infection. Besides, we also demonstrated that the activation of Caspase 3 occurred during the infection process. In conclusion, our results showed that apoptosis in RHD might be determinant in the development of the pathogenesis of RHD.",
        "keywords": [
            "rabbit hemorrhagic disease virus",
            "apoptosis",
            "rk13 cells",
            "caspase 3",
            "dna",
            "staining",
            "flow cytometry"
        ],
        "authors": [
            {
                "name": "Zheng Ni",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Wei Wei",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China;Faculty of Veterinary Medicine,Gansu Agriculture University,Lanzhou ,China"
            },
            {
                "name": "Guang-Qing Liu",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Liu Chen",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Tao Yun",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Jiong-Gang Hua",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            },
            {
                "name": "Shuang-Mao Li",
                "org": "Institute of Virology and Biotechnology,Zhejiang Academy of Agricultural Sciences,Hangzhou ,China"
            }
        ],
        "venue": "Bing du xue bao = Chinese journal of virology / [bian ji, Bing du xue bao bian ji wei yuan hui]",
        "year": 2009
    },
    "OTvYjfnt": {
        "id": "OTvYjfnt",
        "title": "Effect of brace on the pulmonary function of female adolescent patients with idiopathic scoliosis",
        "abstract": "Objective:To investigate the effect of brace on the pulmonary function of female adolescent patients with idiopathic scoliosis(AIS).Method:From February 2001 to December 2009,a total of 283 female AIS patients underwent correction surgery in our hospital.Preoperative pulmonary function tests(PFTs) were evaluated.The predicted value and actual value of forced vital capacity(FVC),forced expiratory volume in one second(FEV1) as well as the ratio of actual and predicted value of FVC(FVC%) and FEV1(FEV1%) were recorded respectively.The patients were classified into two groups according to brace-wearing:group A,preoperative brace,80 cases;group B,no preoperative brace,203 cases.The PFTs between the 2 groups were compared.Multiple linear regression analysis with respect to age,height,coronal Cobb angle of the major curve,number of the involved vertebrae in major curve,sagittal Cobb angle of the thoracic curve,everyday and total brace-wearing time,FVC% and FEV1% were measured finally.Result:The predicted values of FVC in group A and group B were 3.23±0.40L and 3.20±0.40L,and the predicted values of FEV1 were 2.76±0.40L and 2.73±0.30L respectively.No significant difference was noted between 2 groups(both P>0.05).The actual values of FVC in group A and group B were 2.58±0.60L and 2.72±0.60L,and the actual values of FEV1 were 2.34±0.50L and 2.49±0.50L respectively.The FVC% in group A and group B were(80.3±16.5)% and(85.4±16.5)%,and the FEV1% were(85.6±18.4)% and(91.3±16.9)% respectively.The patients in group A had significantly lower FEV1,FVC% and FEV1%(all P<0.05) than group B,especially in patients with primary thoracic curve(173 cases)(P<0.05),however the contrary in patients with primary thoracolumbar/lumbar curve(110 cases)(P>0.05).Group A showed significant positive correlations between sagittal Cobb angle of the thoracic curve and FVC% as well as FEV1%(both P<0.05),while negative correlation between total brace time and FEV1%(P<0.05).The age,height,coronal Cobb angle of the major curve,number of the involved vertebrae of major curve,everyday brace-wearing time(8-23h,average 18.7h) were not associated with FVC% and FEV1%(all P>0.05).Conclusion:Preoperative brace decreases FVC% and FEV1% in female thoracic AIS.The total brace-wearing time and sagittal Cobb angle of thoracic curve may be the risk factors of FVC% and FEV1%.",
        "keywords": [
            "Brace",
            "Pulmonary function test",
            "Adolescent idiopathic scoliosis",
            "Female"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ",et al  Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing,,China"
            },
            {
                "name": "WANG Yipeng",
                "org": ",et al  Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing,,China"
            },
            {
                "name": "QIU Guixing",
                "org": ",et al  Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing,,China"
            }
        ],
        "venue": "Chinese Journal of Spine and Spinal Cord",
        "year": 2011
    },
    "JX6TNprF": {
        "id": "JX6TNprF",
        "title": "The clinical significance of the midline skin lesions in congenital scoliosis patients",
        "abstract": "Objective To investigate the different skin lesions over midline of the spine in congenital scoliosis patients and their clinical significance.Methods Retrospectively reviewed the congenital scoliosis patients that had skin lesions over midline of the spine(myelomeningocele was excluded).Results For the patients who underwent correction surgery in our hospital from 1990 to 2005,63 patients were included in the study and the skin lesions over midline of the spine included hypertrichosis in 32 patients,abnormal pigmentation in 22 patients,subcutaneous mass in 3 patients,skin dimple in 1 patients,hypertrichosis and abnormal pigmentation in 3 patients,hypertrichosis and subcutaneous mass in 2 patients.Thirteen of the 63 patients were found to have intraspinal abnormalities through CT myelography and or MRI examination, which included diastematomyelia in 10 patients,syringomyelia in 2 patients and lipoma in 1 patient.In these 13 patients,3 cases were due to failure of formation,2 cases due to failure of segmentation,8 due to mixed type, 84.6%(11/13) were with multiple vertebral abnormalities.Eight cases of hypertrichosis,3 cases of abnormal pigmentation, 2 cases of subcutaneous mass and 1 case of skin dimple were found to have intraspinal abnormalities.The differences of occurrence of intraspinal abnormalities between patients with different types of skin lesions were none significant. For the 294 congenital scoliosis patients that treated during the same period,11 patients(3.7%) were found to have intraspinal abnormalities.The differences of the occurrences was significant.Conclusion For congenital scoliosis patients, especially for the patients with multiple vertebral abnormalities,skin lesions over midline of the spine may be a marker of intraspinal abnormality.",
        "keywords": [
            "occult spinal dysraphism",
            "cutaneous lesion",
            "intraspinal abnormality",
            "congenital scoliosis"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Wang Yipeng",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Qiu Guixing",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Zhang Jianguo",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Shen Jianxiong",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Weng Xisheng",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Zhao Yu",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Li Qiyi",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Yang Xinyu",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "Zhao Lijuan",
                "org": "Department of Orthopedics,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            }
        ],
        "venue": "Chinese Bone and Joint Surgery",
        "year": 2008
    },
    "8sCZ4S05": {
        "id": "8sCZ4S05",
        "title": "The effect of anterior spinal release on severe adolescent idiopathic scoliosis]",
        "abstract": "To explore the effect of anterior spinal release on severe scoliosis.Twenty-six cases of severe scoliosis were retrospectively reviewed from January 1998 to December 2001. There were 7 males and 19 females with an average age of 15 years (ranging from 10 to 21 years). Twenty-four cases were classified according to King classification for adolescent idiopathic scoliosis, including King type I 4 cases, type II 9 cases, type III 5 cases, King IV 4 cases, King V 2 cases; another two cases were thoracolumbar curve. The major curves were averaged respectively 89.8 degrees, 66.5 degrees, 67.7 degrees, 61.2 degrees on standing, traction, bending and fulcrum film before operation. The distance of apex vertebrae deviated from sacral midline was 39.7 mm before operation.Six cases received anterior spinal release with posterior correction by one stage, 20 cases by two stages. The cases with two stage operation increased the spinal flexibility about 17.8 degrees after anterior release. The major curve was 52.6 degrees on average, and the distance of apex vertebrae deviated from sacral midline was 9.9 mm after operation. The major curve was 54.9 degrees on average, loss the correction 6.4% during follow-up. There was no complication related to the operation in this group.The anterior spinal release alone has little effect on severe scoliosis with flexibility less than 20% preoperation. The curve can be corrected to a great degree by anterior osteotomy for spine.",
        "keywords": [],
        "authors": [
            {
                "name": "Yi-peng Wang",
                "org": "Department of Orthopedic, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China."
            },
            {
                "name": "Hong-guang Xu",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Jian-guo Zhang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2004
    },
    "wEHjDT6S": {
        "id": "wEHjDT6S",
        "title": "Video-assisted thoracoscopic correction and fusion of scoliosis",
        "abstract": "Objective:To evaluate the operative technique and preliminary results of thoracoscopic anterior correction and fusion of scoliosis.Method:Ten cases undergoing thoracoscopic anterior correction and fusion of scoliosis form March 2003 to Januray 2004 were reviewed.9 cases were idiopathic scoliosis and 1 case of congenital scoliosis with an average age of 13.3 years old.The coronal and sagittal Cobb angle,trunk shift,and apical vertebral translation before and after surgery,and at final follow-up were measured,the operation time,intraoperational blood loss volumn,peri-operative complications were documented.Result:The mean operation time was 6.5 hours,the mean number of instrumented vertebrae were 6.3 segments,the mean intraoperational blood loss volumn was 360ml.The coronal Cobb angle of the thoracic curve before and after surgery were 44.0° and 16.4° respectively,with a mean correction rate of 63.2%.The lumbar curve was 29.0° of preoperation and of postoperation 2.9° with a mean simultaneous correction rate of 54.4%.At the final follow-up,the coronal Cobb angle of the thoracic and lumbar curve were 20.1° and 19.6°,with a 3.7° and 6.7° loss of correction respectively.The apical vertebral translation was improved from 28.6mm to 9.6mm for the thoracic curve,and 14.1mm and 8.6mm for the lumbar curve.In the sagittal plane,a preoperative 12.3° of thoracic kyphosis was improved to 23.9° within a normal range.Conclusion:Anterior thoracoscopic correction and fusion of scoliosis had a good correction potention,less intraoperative bleeding and cosmetic effect for mild and moderate thoracic scoliosis,but had a relatively higher loss of correction.",
        "keywords": [
            "Anterior fusion",
            "Scoliosis",
            "scoliosis",
            "Thoracoscopy",
            "anterior fusion",
            "Internal fixation",
            "thoracoscopy",
            "internal fixation"
        ],
        "authors": [
            {
                "name": "ZHANG Jianguo",
                "org": ",et al Department of Orthopaedics, Peking Union Medical College Hospital, Beijing, , China"
            },
            {
                "name": "QIU Guixing",
                "org": ",et al Department of Orthopaedics, Peking Union Medical College Hospital, Beijing, , China"
            },
            {
                "name": "YU Bin",
                "org": ",et al Department of Orthopaedics, Peking Union Medical College Hospital, Beijing, , China"
            }
        ],
        "venue": "Chinese Journal of Spine and Spinal Cord",
        "year": 2006
    },
    "bhS5ukVn": {
        "id": "bhS5ukVn",
        "title": "The efficacy and complications of one stage posterior vertebral column resection for severe spinal deformities]",
        "abstract": "to evaluate the outcomes and complications of posterior vertebral column resection in the treatment of severe and fixed spinal deformities.from January 2008 to January 2010, 15 consecutive cases (4 males, 11 females) of severe and fixed spinal deformities managed by single posterior vertebral column resection with transpedicular instrumentation were investigated retrospectively. The diagnosis included congenital scoliosis in 10 cases, adolescent idiopathic scoliosis in 1 case, congenital kyphosis in 3 cases, tuberculous kyphosis 1 case. Radiographs were measured to determine the regional coronal and sagittal curve magnitude, and the coronal and sagittal balance preoperatively, postoperatively and at the final follow-up. Operative reports and patient charts were reviewed to record operation time, intraoperative blood loss and complications.the mean resected vertebrae was 1.8 (range, 1 - 5). The mean operation time was 331 min (range, 240 - 450 min) with an average blood loss of 1453 ml (range, 800 - 3000 ml). The average follow-up time was 13 months (range, 3 - 24 months). The regional scoliosis was corrected from 111° to 51°with a correction rate of 54.0%, and regional kyphosis from 104° to 39° with a correction rate of 62.5%. No obvious loss of correction was noted at the final follow-up. The coronal trunk shift improved from 19.5 mm preoperatively to 18.1 mm postoperatively and 12.4 mm at final follow-up. The sagittal balance improved from 20.0 mm preoperatively to -2.0 mm postoperatively and -1.1 mm at the final follow-up. Complications included partial pleural rupture requiring repair in 3 cases, transient muscle weakness of one lower limb after surgery but recovered completely at 6 month follow-up in 2 cases, and tightness of thorax after surgery in one case.posterior vertebral column resection is effective in treatment of severe and rigid spinal deformities. But it is a technique-demanding procedure with higher risks of major neurologic complications.",
        "keywords": [],
        "authors": [
            {
                "name": "Jian-Guo Zhang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China. jgzhang_pumch@yahoo.com"
            },
            {
                "name": "Sheng-Ru Wang",
                "org": ""
            },
            {
                "name": "Gui-Xing Qiu",
                "org": ""
            },
            {
                "name": "Yi-Peng Wang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Wu Sun",
                "org": ""
            },
            {
                "name": "Peng-Xiang Jiang",
                "org": ""
            },
            {
                "name": "Hui-Ming Peng",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2010
    },
    "ywmaBGlS": {
        "id": "ywmaBGlS",
        "title": "Radiological evaluation of intervertebral angles on short-segment fusion of degenerative lumbar scoliosis]",
        "abstract": "To analyze the radiological change of intervertebral angles after the short-segment fusion of degenerative lumbar scoliosis.From January 2001 to May 2007, 28 patients (mean age 62 years old) with degenerative lumbar scoliosis, including 6 male and 22 female, were reviewed retrospectively. The average vertebra number in the lumbar curve were 4.8, ranging from 3 to 6. All the patients underwent posterior decompressive laminotomy, pedicle screw fixation, and posterolateral fusion. The fusion levels were within the curve in all the cases (mean 3.3 vertebrae), without exceeding the end vertebrae. All the patients took standing lumbar antero-posterior and sagittal radiological images pre and post-surgery and upon follow up. The coronal scoliosis Cobb angle, anterior and sagittal intervertebral angles of upper adjacent segment of proximal fused vertebra were measured. The following aspects were also evaluated such as bone graft fusion and complications.Follow up period of 25-97 months, average 50 months; post-operative scoliosis Cobb angle average correction rate was 33.7%, final follow up average correction loss was 3.7 degrees , pre-operative and final follow up results compared with post-operative indicated significant difference (P < 0.05); final follow-up antero-posterior proximal upper fusion segment intervertebral angle compared with pre-operative and postoperative presenting significant difference (P < 0.05). Upon final follow up, all cases did not present pseudo-arthrosis or internal instrumentation related complications.For degenerative lumbar scoliosis, short-segment fusion can produce limited correction on antero-posterior proximal upper fusion segment intervertebral angle and cannot stop its aggravation.",
        "keywords": [],
        "authors": [
            {
                "name": "Nai-guo Wang",
                "org": "Orthopaedic Department, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China."
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Jian-guo Zhang",
                "org": ""
            },
            {
                "name": "Jian-xiong Shen",
                "org": ""
            },
            {
                "name": "Yu Zhao",
                "org": ""
            },
            {
                "name": "Shu-gang Li",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2010
    },
    "nqcOJCp5": {
        "id": "nqcOJCp5",
        "title": "Influence of different surgical approaches on the changes of the interspace angle in adolescent idiopathic thoracolumbar/lumbar scoliosis",
        "abstract": "Objectives To evaluate the different influences on the interspace angle changes after anterior or posterior correction and fusion in adolescent idiopathic thoracolumbar/lumbar scoliosis.Methods By reviewing the medical records and roentgenograms of adolescent idiopathic thoracolumbar/lumbar scoliosis patients underwent anterior(Group A) or posterior(Group B)correction and instrumentation,Cobb angle of the curve,correction rate,and interspace angle were measured and analyzed.Results There were 30 patients in group A,and 12 patients in group B.The mean preoperative and post-operative coronal Cobb angles of the main curve in group A and group B were 48.9 and 11.7,44.3 and 5.3,respectively,with an average correction rate of 76.1%and 87.7%.At the final follow-up,the coronal Cobb angles in the two groups were 18.1 and 7.7,respectively.The interspace angles before operation,after operation and at final follow-up were 3.2,5.6 and 8.2 in group A,and 3.3,3.6 and 3.2 in group B,respectively.Between the 2 groups, the coronal Cobb angle after operation,correction rate,coronal Cobb angle at final follow-up,coronal Cobb angle loss of the main curve in group B were all better than that in group A(P =0.022,P =0.022,P =0.005,P=0.O19).The difference of the interspace angle after operation was not sifgnificant(P = 0.068),while at final follow-up,group A had a larger interspace angle(P = 0.001)and a greater loss of the interspace angle(P = 0.043).Conclusions For adolescent idiopathic thoracolumbar/lumbar scoliosis,compared to anterior approach,posterior approach using all pediele screws obtains a better interspace angle with a less interspace angle loss upon final follow-up.",
        "keywords": [
            "Anterior fusion",
            "Interspace angle",
            "Idiopathic scoliosis",
            "Posterior fusion"
        ],
        "authors": [
            {
                "name": "WANG Yi-peng",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "QIU Gui-xing",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "ZHANG Jian-guo",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "FEI Qi",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "SHEN Jian-xiong",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "LI Qi-yi",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "YANG Xin-yu",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "ZHAO Li-juan",
                "org": " Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            }
        ],
        "venue": "Chinese Bone and Joint Surgery",
        "year": 2008
    },
    "SDX05WUw": {
        "id": "SDX05WUw",
        "title": "Anterior thoracoscopic approach of thoracic spine in adolescent idiopathic scoliosis]",
        "abstract": "The use of anterior surgical techniques for the treatment of adolescent idiopathic scoliosis (AIS) has increased recently and anterior discectomy, anterior release and fusion, instrumentation of the thoracic scoliosis can be performed through a thoracoscopic approach. The thoracoscopic approach has several advantages: small surgical trauma, early return to work, reduced postoperative pain and improved postoperative respiratory functions. Although the thoracoscopic approach still has some shortcomings currently, it will be widely accepted with further development of this technique and instrumentations in the future.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedic Surgery, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. d-yubin@sohu.com"
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2003
    },
    "hiz1biS5": {
        "id": "hiz1biS5",
        "title": "Comparative analysis of the inter-observer reliability and intra-observer reproducibility between Lenke and PUMC classification systems for adolescent idiopathic scoliosis]",
        "abstract": "To compare the intra-observer reproducibility and inter-observer reliability regarding the results of Lenke's and Peking Union Medical College (PUMC) classification systems for adolescent idiopathic scoliosis (AIS).Five spine surgeons independently measured the X ray films of 62 AIS patients using both Lenke and PUMC classification systems. Three weeks later, the spine surgeons repeated the same classification process. No measurement trace was allowed to be left on the X ray films. SAS software was used to calculate the Kappa values and analyze the intra-observer reproducibility and inter-observer reliabilityThe overall reliability and reproducibility rates of the Lenke classification system were 69.8% (Kappa value = 0.675) and 74.2% (Kappa value = 0.690) respectively, in which the curve characteristic parameter reliability and reproducibility rates were 86.5% (Kappa value = 0.808) and 87.4% (Kappa value 0.826) respectively, the lumbar correction reliability and reproducibility rates were 95.2% (Kappa value = 0.919) and 94.5% (Kappa value = 0.908) respectively, and the sagittal thoracic correction reliability and reproducibility rates were 85.2% (Kappa value = 0.734) and 89.0% (Kappa value = 0.805 respectively). The reliability and reproducibility rates of the PUMC classification system were 91.0% (Kappa value = 0.896) and 90.2% (Kappa value = 0.892) respectively.The reliability and reproducibility rates of the Lenke classification system were better than the previously reported results. However, the PUMC classification system expresses better reliability and reproducibility. The PUMC classification system is relatively easier with fewer curve types, hence leading to less divergence among the clinicians. Comparing to the classifications used in the past, both classification systems have the advantages of correctly categorizing AIS according to its individual traits, as well as accurately examining the X ray results, hence achieving significance in terms of surgical outcome and design.",
        "keywords": [
            "scoliosis",
            "classification",
            "comparative study"
        ],
        "authors": [
            {
                "name": "Gui-xing Qiu",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College, Beijing 100730, China."
            },
            {
                "name": "Qi-yi Li",
                "org": ""
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Jian-guo Zhang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Ting Wang",
                "org": ""
            },
            {
                "name": "Ke-yi Yu",
                "org": ""
            },
            {
                "name": "Jun Qian",
                "org": ""
            },
            {
                "name": "Yu Zhao",
                "org": ""
            },
            {
                "name": "Jia-yi Li",
                "org": ""
            },
            {
                "name": "Jian-xiong Shen",
                "org": ""
            },
            {
                "name": "Xi-sheng Weng",
                "org": ""
            },
            {
                "name": "Xin-yu Yang",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2007
    },
    "CDPIQJPe": {
        "id": "CDPIQJPe",
        "title": "Clinical features of adolescent idiopathic scoliosis with thoracolumbar kyphosis and its surgical treatment]",
        "abstract": "To summarize the clinical features and evaluate the surgical results of adolescent idiopathic scoliosis (AIS) with thoracolumbar kyphosis.Four hundred and thirteen AIS patients were retrospectively reviewed between January 2001 and January 2007. Among them, 10 patients had thoracolumbar kyphosis, including 2 males and 8 females. The average age at surgery was 14.3 years old. There were 3 PUMC type IIb2, 4 PUMC IIc3, 1 PUMCIId2, 2 PUMC IIIb. Eight patients underwent posterior correction and spinal fusion with instrumentation, 2 patients underwent anterior release, posterior correction and spinal fusion with instrumentation. By reviewing the roentgenograms of patients, the curve type, Cobb angle, flexibility, apical rotation and translation, coronal and sagittal trunk shift and thoracolumbar kyphosis were measured and analyzed.Eight patients had double curves and 2 patients had triple curves. Among them, the Cobb angles of thoracolumbar or lumbar curve were larger than 45 degrees in 7 patients, the flexibility index was less than 70% in 6 patients, the apical vertebral rotation was larger than II degrees in 9 patients and the apical vertebral translation was larger than 2 cm in all patients. All the surgical treatment strategy and fusion level followed the criteria of PUMC classification. The coronal Cobb angles of thoracic curve before and after surgery were 71.7 degrees and 37.4 degrees respectively, and the average correction rate was 47.8%. The coronal Cobb angles of thoracolumbar or lumbar curve before and after surgery were 65.0 degrees and 27.8 degrees respectively, and the average correction rate was 57.2%. The Cobb angles of thoracolumbar kyphosis before and after surgery were 35.5 degrees and 4.2 degrees respectively, and the average correction rate was 88.2%. No trunk decompensation was noted at final follow-up. All patients were followed-up from 12 to 72 months; the average follow up was 23.1 months.AIS patients with thoracolumbar kyphosis usually have double or triple curves. In these patients, thoracolumbar curves or lumbar curves are severe and have obvious rotatory deformity. Thoracolumbar curve or lumbar curve should be fused in idiopathic scoliosis patients with thoracolumbar kyphosis to avoid trunk decompensation or junctional kyphosis. By using criteria of PUMC classification, these patients can be well identified and corresponding fusion level can be followed as well.",
        "keywords": [],
        "authors": [
            {
                "name": "Ke-yi Yu",
                "org": "Department of Orthopaedic, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China."
            },
            {
                "name": "Jian-guo Zhang",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Jian-xiong Shen",
                "org": ""
            },
            {
                "name": "Hong Zhao",
                "org": ""
            },
            {
                "name": "Xi-sheng Weng",
                "org": ""
            },
            {
                "name": "Yu Zhao",
                "org": ""
            },
            {
                "name": "Shu-gang Li",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2009
    },
    "sZn0kxuG": {
        "id": "sZn0kxuG",
        "title": "Extracellular signal-regulated kinase inhibition modulates rat annulus fibrosus cell response to interleukin-1.",
        "abstract": "Rat annulus fibrosus (AF) cells were activated with interleukin-1 (IL-1) with or without extracellular signal-regulated kinase (ERK) inhibition. Factors associated with the anabolic/catabolic balance of the disc were determined.To clarify the role of ERK pathway in AF cells response to IL-1.IL-1 plays an important role in intervertebral disc degeneration. ERK is an important inflammatory pathway that plays a crucial role in the expression of inflammatory and catabolic genes induced by IL-1 in chondrocytes. However, the role of the ERK pathway in AF cells response to IL-1 has not been fully investigated.Rat AF cells in monolayer culture were exposed to IL-1, with or without ERK inhibition; ribonucleic acid was isolated for real time polymerase chain reaction analysis of gene expression, conditioned media analyzed for nitrite, prostaglandin E-2, and IL-6, Western blot was performed to detect the changes of protein expression.ERK specific inhibitor U0126 significantly inhibited IL-1-induced ERK activation. IL-1-dependent upregulation of iNOS, IL-6, Cox-2, (MMP)-3, and MMP-13 was significantly reduced by ERK inhibition. The decreased gene expression of collagen I, collagen II, collagen IX, and IGF-1 induced by IL-1 was also reversed by U0126. Gene expression of ADAMTS-4, ADAMTS-5, and TGF-b were not affected by IL-1 or ERK inhibition. IL-1 moderately upregulated aggrecan and TIMP-1 expression, ERK inhibition had no significant effect on aggrecan expression but decreased TIMP-1 expression in the presence of IL-1. ERK inhibition reversed the changes of protein expression of MMP-3, MMP-13, TIMP-1, aggrecan and collagen II induced by IL-1. IL-1-induced nitric oxide, prostaglandin E-2, and IL-6 accumulation were also reduced by ERK inhibition.These results suggest that IL-1 induces an imbalance between anabolic and catabolic events in AF cells, ERK inhibition could provide some protection against the adverse effects of IL-1.N/A.",
        "keywords": [
            "signaling pathway",
            "disc degeneration",
            "il-1",
            "annulus fi brosus cells",
            "erk"
        ],
        "authors": [
            {
                "name": "Yuan Wei",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Wu Zhi-Hong",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Qiu Gui-Xing",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yu Bin",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Chen Jun",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Wang Yi-Peng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Spine",
        "year": 2013
    },
    "XLXKJyMU": {
        "id": "XLXKJyMU",
        "title": "Comparison of instrumented posterior fusion with instrumented circumferential lumbar fusion in the treatment of lumbar stenosis with low degree lumbar spondylolisthesis]",
        "abstract": "To compare and evaluate instrumented posterior fusion with instrumented circumferential lumbar fusion in the treatment of lumbar stenosis with low degree lumbar spondylolisthesis.From April 1998 to April 2003, 45 patients who suffered from lumbar stenosis with low degree lumbar spondylolisthesis were divided into 2 groups (A and B) at random. The patients in group A (n = 24, average age 54 years old) were performed decompressive laminectomy, intertransverse process arthrodesis with bone grafting and transpedicle instrumentation of solid connection (SOCON) system. The patients in group B (n = 21, average age 53 years old) were performed the same procedure as group A except adding posterior lumbar interbody fusion (PROSPACE). The main levels of lumbar spondylolisthesis in 2 groups was L(4 - 5) or L(5)-S(1). All cases were classified as degree 1 to degree 2. All patients in the two groups received preoperative myelography or CTM, and were diagnosed lateral recess stenosis and(or) central lumbar canal stenosis.All the patients were followed up from 12 to 72 months. In group A, the results showed that the preoperative clinical symptoms disappeared completely in 12 of 24 patients, pain relief was seen in 91.7% (22/24), anatomical reduction rate was 91.7%. No infection or neurologic complication occurred in this series. In group B, the results showed that the preoperative clinical symptoms disappeared completely in 13 of 21 patients, pain relief was seen in 90.5% (19/21), anatomical reduction rate was 95.2%. Four cases of infection or neurologic complication occurred in this series. Two groups had no significant difference in follow-up clinical outcome and anatomical reduction rate. But group A had better intraoperative circumstances and postoperative outcome than group B, group B had better postoperative parameters in X-ray of angle of slipping and disc index than group A.The best surgical treatment method of lumbar stenosis with low degree lumbar spondylolisthesis is complete intraoperative decompressive laminectomy, reduction with excellent transpedicle system instrumentation and solid fusion after bone grafting. The use of cage should be conformed to strict indications.",
        "keywords": [
            "lumbar vertebrae",
            "spinal fusion",
            "spondylolisthesis",
            "spinal stenosis"
        ],
        "authors": [
            {
                "name": "Qi Fei",
                "org": "Department of Orthopaedic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. feiqi@medmail.com.cn"
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Hong-guang Xu",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Xi-sheng Weng",
                "org": ""
            },
            {
                "name": "Jin Lin",
                "org": ""
            },
            {
                "name": "Ye Tian",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Rui Xu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2005
    },
    "lCTCBqkr": {
        "id": "lCTCBqkr",
        "title": "Application and analysis of King,Lenke and PUMC classifications of idiopathic scoliosis",
        "abstract": "Objective To compare the comprehension and the role of King, Lenke and PUMC classifications in the surgical treatment of adolescent idiopathic scoliosis. Methods Medical records and radiographs of 145 patients who underwent surgical treatment in Hospital Sant Joan De Déu were reviewed. Each patient was classified according to the different classifications and related fusion levels, and postoperative decompensation was analyzed. Results All the 145 cases could be classified by Lenke and PUMC classifications. Only 122 cases could be classified according to King classification. The fusion levels were coincided with King classification in 99 cases, Lenke classification in 120 cases and PUMC classification in 107 cases. 95 patients followed up regularly, with an average of 29.6 months (range, 3 to 96 months). The rates of coronal decompensation after operation and at final follow-up were 26.3% (26/99) and 13.2% (9/68), 30.8% (37/120) and 12.5% (10/80), 14.0% (15/107) and 2.7% (2/74) when fusion level meeting with the criteria of King classification, Lenke classification and PUMC classification, respectively. There were significant differences of the coronal decompensation rates between PUMC and King or Lenke classification (P < 0.05). The flexibility of the proximal thoracic and main thoracic curves were different from those of the thoracolumbar and lumbar curves (P < 0.05). Conclusion Of the three classifications, PUMC and Lenke classifications are more comprehensive than King classification, and PUMC classification is more practical in the selection of fusion levels than the two others. It's not appropriate to use the same criterion of Cobb angle larger than 25° on the convex Bending film as a definition of structural curve for different curves in the different sites.",
        "keywords": [
            "Scoliosis",
            "Classification",
            "Spinal fusion",
            "Adolescent"
        ],
        "authors": [
            {
                "name": "QIU Gui-xing",
                "org": ", Norbert Ventura, et al. *Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , China"
            },
            {
                "name": "YU Bin",
                "org": ", Norbert Ventura, et al. *Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Orthopaedics",
        "year": 2006
    },
    "7ermdpYt": {
        "id": "7ermdpYt",
        "title": "What is the optimum fusion technique for adult spondylolisthesis-PLIF or PLF or PLIF plus PLF? A meta-analysis from 17 comparative studies.",
        "abstract": "A meta-analysis and systemic review.To pool scientific evidence for the optimum selection in the treatment of lumbar spondylolisthesis by comparing the clinical effect of posterolateral fusion (PLF), posterior lumbar interbody fusion (PLIF), and PLIF plus PLF.Clinical effect of the 3 fusion techniques has been reported in many studies. However, which is the best method is in dispute.A systematic search was conducted in MEDLINE, EMBASE, and the Cochrane Collaboration Library from January 1950 through May 2013. Comparative studies were performed according to eligibility criteria. Weighted mean differences and risk differences were calculated for common outcomes. The final strength of evidence was expressed as different level recommended by the Grading of Recommendations Assessment, Development, and Evaluation Working Group.Four randomized controlled trials and 13 observational studies were eligible. PLIF was more effective than PLF in the improvement of clinical satisfaction (odds ratio [OR], 0.52; 95% confidence interval (CI), 0.31-0.89; P=0.02). No significant differences in the primary outcomes were seen between PLIF plus PLF and PLF (OR, 0.88; 95% CI, 0.47-1.64; P=0.69). For the complication rate, the differences were not significant between PLIF and PLF, and between PLIF plus PLF and PLF (OR, 2.27; 95% CI, 0.95-5.42; P=0.07; OR, 0.74; 95% CI, 0.22-2.44; P=0.62, respectively). In the secondary outcomes, PLIF was more effective than PLF in the improvement of fusion rate (P=0.0007) and reoperation rate (P=0.004). However, PLIF plus PLF failed to reveal more superiority than PLF (P>0.05).PLIF plus PLF did not show more superiority than PLF alone. PLIF alone improved clinical satisfaction and decreased complication rate compared with PLF. PLIF maybe be better than the other 2 fusion methods in the treatment of lumbar spondylolisthesis. However, conclusions need to be treated with caution because of lack of high quality of evidence.1.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiao-Yang Liu",
                "org": "*Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China; and †Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Gui-Xing Qiu",
                "org": ""
            },
            {
                "name": "Xi-Sheng Weng",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Yi-Peng Wang",
                "org": ""
            }
        ],
        "venue": "Spine",
        "year": 2014
    },
    "odfK00zG": {
        "id": "odfK00zG",
        "title": "Association between polymorphism of vitamin D receptor gene and degenerative disc disease of lumbar spine in northern China",
        "abstract": "Background:It is believed that degenerative disc disease(DDD)is a complex/multifactorial disease determined by the interplay between gene(s)and the environment.Vitamin D receptor(VDR)gene may be associated with DDD. Objective:The aim of the study is to investigate the association between VDR gene polymorphism and DDD. Methods:A total of 118 patients with lumbar DDD and 112 healthy controls were enrolled in this hospital-based case-control study.Genotying of all selected single nucleotide polymorphism(SNP)was done by SNP stream technology.The differences of the allele frequency of VDR gene between the DDD patients and the healthy controls was analyzed by Goodness-of-fit Chi-square test. Results:Sixteen SNPs were studied.The allele frequency distribution of rs2239179 was different between the DDD patients and the healthy controls(P=0.046),while there was no significant difference when performing Permutation correction(P= 0.4299).There were no significant differences of the allele frequency distributions of other 15 SNPs between the DDD patients and the healthy controls(all P>0.05).There were no significant differences of the genotype of all 16 SNPs between the DDD patientsand the healthy controls(all P>0.05).In the unconditional logistic regression analysis,no SNPs showed significant in Codominant,Dominantand,Recessive,Overdominant or Log-additive model.There were no significant differences of haplotype frequencies of VDR gene between the case group and the control group. Conclusions:Genetic variants of VDR gene may not associate with lumbar DDD in northern China.",
        "keywords": [
            "vitamin D receptor gene",
            "lumbar degenerative disc disease",
            "single nucleotide polymorphism",
            "gene polymorphism"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Wu Zhihong",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Qiu Guixing",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Wang Yipeng",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Weng Xisheng",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Zhou Xi",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Zhang Jianguo",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Zhao Yu",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            },
            {
                "name": "Li Shugang",
                "org": "Department of Orthopedics,Peking Union Medical College Hospital,CAMS&PUMC,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bone and Joint Surgery",
        "year": 2012
    },
    "GfVuWZ3d": {
        "id": "GfVuWZ3d",
        "title": "Selective thoracic fusion in adolescent idiopathic scoliosis]",
        "abstract": "To define the criteria of selective thoracic fusion in adolescent idiopathic scoliosis patients.By reviewing the roentgenograms of adolescent idiopathic scoliosis patients undergoing selective thoracic fusion, the curve type, Cobb angle, apical rotation and translation, trunk shift, and thoracolumbar kyphosis were measured and analyzed.There were 12 King type II patients (PUMC type: IIb1 9, IIc3 3). The coronal Cobb angle of thoracic curve before and after surgery were 54.0 degrees and 19.0 degrees respectively, and the average correction rate was 62.7%. The coronal Cobb angle of lumbar curve before and after surgery were 34.6 degrees and 12.5 degrees respectively, and the average spontaneous correction rate was 64.7%. At the final follow-up, the coronal Cobb angle of thoracic and lumbar curve was 18.8 degrees and 15.9 degrees respectively. There was no significant change in the coronal Cobb angle, apical vertebral translation and rotation compared with that after surgery. 1 patient had 12 degrees of thoracolumbar kyphosis after surgery, no progression was noted at the final follow-up. There was no trunk decompensation or deterioration of the lumbar curve. In this group, 3.5 levels were saved compared with fusing both the thoracic and lumbar curves.Selective thoracic fusion can be safely and effectively performed in patients with a moderate and flexible lumbar curves, which can save more mobile segments to maintain a good coronal and sagittal balance.",
        "keywords": [],
        "authors": [
            {
                "name": "Jian-guo Zhang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China."
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Xi-sheng Weng",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Hong-guang Xu",
                "org": ""
            },
            {
                "name": "Xin-yu Yang",
                "org": ""
            },
            {
                "name": "Yu-zhu Ren",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2004
    },
    "cPmS7oNU": {
        "id": "cPmS7oNU",
        "title": "Selective anterior thoracolumbar or lumbar fusion for adolescent idiopathic scoliosis]",
        "abstract": "To evaluate the outcomes of selective anterior thoracolumbar or lumbar (TL/L) fusion for adolescent idiopathic scoliosis (AIS) with PUMCIId1 curves (Lenke type 5).Thirty-five consecutive AIS patients (PUMC type IId1, Lenke type 5) with selective anterior TL/L fusion with single solid rod instrumentation were reviewed. The average follow-up was 36 months (range, 18 - 42 months). Standing anteroposterior and lateral radiographs were measured and analyzed.The average preoperative Cobb angle of the TL/L curves was 45.6 degrees and corrected to 9.7 degrees postoperatively, with 79.7% curve correction. The thoracic curves decreased from 29.7 degrees preoperatively to 17.6 degrees postoperatively, with a spontaneous correction of 41.5%. There was an average 4.7 degrees and 2.5 degrees correction loss of the TL/L and the thoracic curves at the final follow-up respectively. Trunk shift deteriorated slightly from 14.0 mm preoperatively to 14.8 mm postoperatively, and improved significantly to 5.1 mm at the final follow-up. The lowest instrumented vertebra (LIV) tilt was significantly improved after surgery (from -21.8 degrees preoperatively to -1.5 degrees postoperatively) and well maintained at the final follow-up (-2.1 degrees). The coronal disc angle immediately above the upper instrumented vertebra (UIVDA) and below the LIV (LIVDA) averaged 0.5 degrees and 0.6 degrees respectively, and aggravated after surgery (0.9 degrees and 4.9 degrees, respectively). Both the UIVDA and LIVDA were significantly aggravated at the final follow-up (3.0 degrees and 7.8 degrees, respectively). The sagittal contours of T(5-12) and T(10)-L(2) were well maintained after surgery and at the final follow-up. The lumbar lordosis of L(1)-S(1) and the sagittal Cobb angle of the instrumented segments were reduced postoperatively and at the final follow-up. No pseudarthrosis or other complications were observed.Selective anterior TL/L fusion with single solid rod instrumentation is effective and safe for AIS with PUMCIId1 (Lenke type 5) curves, above and below the fusion and larger residual thoracic curve in some cases need further evaluated.",
        "keywords": [],
        "authors": [
            {
                "name": "Wen-can Lu",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China."
            },
            {
                "name": "Jian-guo Zhang",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Ilgar Sadik",
                "org": ""
            },
            {
                "name": "Yi-peng Wang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Hong Zhao",
                "org": ""
            },
            {
                "name": "Yu Zhao",
                "org": ""
            },
            {
                "name": "Xi-sheng Weng",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2009
    },
    "vUXqTROL": {
        "id": "vUXqTROL",
        "title": "Influence of different instrumentation fashions on the correction results of posterior selective thoracic fusion in adolescent idiopathic scoliosis patients",
        "abstract": "Objectives To analyze the influence on the correction results of different instrumentation correction results of posterior selective thoracic fusion in adolescent idiopathic scoliosis patients.Methods We reviewed the medical records and roentgenograms of adolescent idiopathic scoliosis patients underwent selective thoracic fusion.Patients were classified into 3 group according to different instrumentations:group A:hooks-only type;group B:mixed hook and screw type;and group C:screws-only type,and the screws were used in every segment on the concave side of the thoracic curve.The parameters of the scoliosis and analyze the correction results were measured.Results There were totally 57 patients in this series(8 male and 49 female),with an average age of 14.3 years old.The average follow-up time was 19.6 months.The mean coronal Cobb angle of the thoracic curve among the 3 groups were 49.0°,48.8°,and 47.4°before surgery,and 15.1°,13.7°,and 6.8°after surgery,with an average correction rate of 62.1%,64.6%,and 79.0%.The correction rates of group B and C were significantly higher than group A(P =0.001,P =0.001),and that of group C significantly was higher than group B(P = 0.000).The mean coronal Cobb angle of the lumbar curve among the 3 groups were 32.4°,32.6°,and 35.2°,before surgery,and 12.0°,8.6°,and 8.3°after surgery,with an average correction rate of 62.3%,73.7%,and 76.6%(P =0.000).The coronal Cobb angle of the lumbar curve among the 3 groups were 16.3°,10.3°,and 11.1°,respectively,with an average correction rate of 48.9%,66.8%and 69.9%,with no significant loss(P>0.05).While the correction rates of group B and C were significantly higher than that of group A(P = 0.012,P = 0.008),it was significantly higher in group C than in group B(P = 0.003).Conclusions Despite of different instrumentation selection,good correction of the thoracic curve and satisfactory spontaneous correction of the lumbar curve can be obtained in posterior selective thoracic fusion of adolescent idiopathic scoliosis.The complete pedicle screw group has the best correction results.",
        "keywords": [
            "Internal fixator",
            "Pedicle screw",
            "Selective thoracic fusion",
            "Idiopathic scoliosis"
        ],
        "authors": [
            {
                "name": "ZHANG Jian-guo",
                "org": ",et al Department of Orthopedics, Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al Department of Orthopedics, Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            },
            {
                "name": "QIU Gui-xing",
                "org": ",et al Department of Orthopedics, Peking Union Medical College Hospital,CAMS & PUMC,Beijing ,China"
            }
        ],
        "venue": "Chinese Bone and Joint Surgery",
        "year": 2008
    },
    "2aaIflR3": {
        "id": "2aaIflR3",
        "title": "Selective thoracic fusion in the scoliosis associated with syringomyelia]",
        "abstract": "To evaluate the surgical results of selective thoracic fusion (STF) for scoliosis associated with syringomyelia.From January 2001 to January 2009, 93 cases of scoliosis associated with syringomyelia were retrospectively reviewed. There were 11 cases who underwent STF and were followed up more than 2 years, which included 8 female and 3 male, the mean age was 14.9 years (9 - 21 years). Curve type, coronal and sagittal Cobb angle, apical vertebral rotation apical vertebral translation, flexibility, trunk shift were recorded and analyzed.There were 9 double curves and 2 triple curves, the Lenke type of thoracolumbar/lumbar curve included Lenke A in 2 cases, Lenke B in 7 cases and Lenke C in 2 cases. The average coronal Cobb angle of thoracic curve before and after surgery were 62.6° and 19.0° respectively, and the average correction rate was 69.6%. The average coronal Cobb angle of thoracolumbar/lumbar curve before and after surgery were 36.1° and 11.6° respectively, and the average spontaneous correction rate was 67.9%. The followed up time ranged from 24 to 48 months (mean 29.5 months), the average loss of correction rate was 6.8%. Only one trunk decompensation was noted at final follow-up. Pedicle screw nut loosening occurred in one patient and this patient underwent revision surgery, no neurological complication was noted at final follow-up.STF could be safely performed in scoliosis associated with syringomyelia. Thoracolumbar/lumbar curve in these patients has similar spontaneous correction ability compared with idiopathic scoliosis patients. The satisfactory result could be achieved according to the STF criteria for IS.",
        "keywords": [],
        "authors": [
            {
                "name": "Ke-Yi Yu",
                "org": "Department of Orthopaedic, Peking Union Medical College Hospital, Beijing, China."
            },
            {
                "name": "Jian-Xiong Shen",
                "org": ""
            },
            {
                "name": "Gui-Xing Qiu",
                "org": ""
            },
            {
                "name": "Jian-Guo Zhang",
                "org": ""
            },
            {
                "name": "Yi-Peng Wang",
                "org": ""
            },
            {
                "name": "Yu Zhao",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2011
    },
    "BNGGstGo": {
        "id": "BNGGstGo",
        "title": "Analysis of the correction results of the adolescent idiopathic scoliosis patients with a proximal thoracic curve]",
        "abstract": "To analyze the correction results of the adolescent idiopathic scoliosis patients with a proximal thoracic (PT) curve.There were 13 cases of double thoracic curve (PUMC IIa) and 13 cases of triple curve (PUMC IIIa 11 cases, IIIb 2 case). The upper instrumented vertebra were at T(3) or above (fusion level including PT curve, Group A) in 18 cases, and at T(4) or T(5) (PT curve not fused, Group B) in 8 cases. Reviewing the medical records and radiographs of 26 adolescent idiopathic scoliosis patients with a proximal thoracic curve that underwent corrective surgery, the changes of the curve and the shoulder balance were analyzed.The coronal Cobb angles of the PT curve and the main thoracic (MT) curve before operation were 45.3 degrees and 61.2 degrees in group A, 35.6 degrees and 58.9 degrees in group B. After operation, they were corrected to 24.2 degrees and 20.1 degrees , 26.4 degrees and 20.3 degrees , respectively. The correction rates of the PT curve and MT curve were 48.2% and 68.7%, 24.5% and 66.3%, respectively. The correction rates of the PT curve of group A was significantly better than group B (P = 0.006), but for the MT curve, the difference was not significant (P = 0.694). The incidence of radiographic shoulder height (RSH) over than 10 mm (shoulder imbalance) after operation in group B was higher than group A significantly (P = 0.038). The incidence rate of shoulder imbalance after operation of the patients with a left higher shoulder or balance shoulder was significantly higher than that of the patients with a right higher shoulder (P = 0.015).Fusing the PT in patients with a left shoulder not lower than right side will make better coronal correction results of the PT curve and reduce the incidence of postoperative shoulder imbalance.",
        "keywords": [
            "scoliosis",
            "proximal thoracic curve",
            "adolesence",
            "radiographic shoulder height"
        ],
        "authors": [
            {
                "name": "Gui-xing Qiu",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Yi-peng Wang",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Bin Yu",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Jian-guo Zhang",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Jian-xiong Shen",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Xi-sheng Weng",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Qi-yi Li",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Xin-yu Yang",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            },
            {
                "name": "Li-juan Zhao",
                "org": " Department of Orthopaedic Surgery,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing ,China"
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2007
    },
    "OR4nklqL": {
        "id": "OR4nklqL",
        "title": "Meta-analysis of circumferential fusion versus posterolateral fusion in lumbar spondylolisthesis.",
        "abstract": "Literature review and meta-analysis.Posterolateral fusion (PLF) and circumferential fusion (CF) were widely used in the treatment of lumbar spondylolisthesis. There was a great controversy over the preferred fusion method.We performed a meta-analysis for determining which fusion method was better in lumbar spondylolisthesis.A systematic search was conducted in MEDLINE, EMBASE, and the Cochrane Collaboration Library from January 1960 to December 2013. Comparative studies were selected according to eligibility criteria. Weighed mean differences (WMDs) and risk differences were calculated. The final strength of evidence was expressed as different levels recommended by the GRADE Working Group.Eight comparative studies were identified. There was less evidence that no significant difference was found between CF and PLF for clinical satisfaction [odds ratio (OR), 0.63; 95% confidence interval (95% CI), 0.30, 1.32; P=0.22)] and for complication rate (OR, 0.64; 95% CI, 0.23, 1.76; P=0.39). The PLF was more effective than the CF for the reduction of complication rate for patients with isthmic spondylolisthesis (OR, 0.44; 95% CI, 0.23, 0.86; P=0.02). There was no significant difference for fusion rate, reoperation rate, operating time, and blood loss. Subanalysis showed that the CF can increase the fusion rate of patients with isthmic spondylolisthesis (OR, 0.12; 95% CI, 0.01, 1.00; P=0.05). PLF was more effective than CF for the reduction in operating time (WMD=-75.68; 95% CI, -99.00, -52.37; P<0.00001), and CF was more effective than PLF for the restoration of segment lordosis, disk height, and spondylolisthesis.There was really no difference for clinical satisfaction, complication rate, fusion rate, reoperation rate, operating time, and blood loss. PLF can reduce complication rate and operating time. CF can improve fusion rate for individuals with isthmic spondylolisthesis and restore lumbar alignment. The level of evidence was low.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiao-Yang Liu",
                "org": "Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing, China."
            },
            {
                "name": "Yi-Peng Wang",
                "org": ""
            },
            {
                "name": "Gui-Xing Qiu",
                "org": ""
            },
            {
                "name": "Xi-Sheng Weng",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of spinal disorders & techniques",
        "year": 2014
    },
    "1Vg0bCo5": {
        "id": "1Vg0bCo5",
        "title": "Surgical treatment of lumbar spinal stenosis associated with unstable degenerative spondylolisthesis]",
        "abstract": "To assess surgical treatment of lumbar spinal stenosis associated with unstable degenerative spondylolisthesis.In 86 patients with lumbar spinal stenosis associated with unstable degenerative spondylolisthesis. (30 men and 56 women, aged from 30 to 77 years), 63 patients complained of lower back pain with both lower extremity pain, 10 patients pain in one leg, and 13 patients only lower back pain. Seventy-two of these patients complained of intermittent claudication, with a walking distance ranging from 10 to 1 000 m. Thirty-two patients had some changes in sensation, motion and reflexes of the foot. According to White' critera, all patients showed dynamic instability of the lesion. Meyerding criteria showed degree 1 in 79 patients, and degree 2 in 7. CT scan was made in 56 patients, MRI in 24 and MRM in 6 before operation. Myelography was performed in 61 patients, and CTM in 6. Stenosis and spondylolisthesis located between L(4) and L(5) in 49 patients, between L(3) and L(4) in 6, between L(5) and S(1) in 25, between L(3) and L(4) and between L(4) and L(5) in 2, and from L(3) to S(1) in 4. The patients with pathological spondylolisthesis were excluded. Lateral recess stenosis of one leg was observed in 10 patients, lateral recess of both legs in 22, and central canal stenosis in 54, of whom 12 patients were associated with protrusion of the lumbar disc. Decompression and autograft with iliac bone and various internal fixation were performed in all patients.The patients were followed up from 8 months to 13 years, longer than 1 year (average 5.6 years) in 81 patients. According to Amundsen et al, excellent results were obtained in 78 patients, good in 5, and fair in 3. Spondylolisthesis was completely reduced in 70 patients of degree 1 (89.9%), and in 6 patients of degree 2 (85.7%). No patient showed slippage aggravated. 74 patients gained bone graft fusion within 3 months and 10 patients within 6 months. Two patients showed pseudoarthrosis during the follow-up. Complications included internal fixation breakage in 1 patient, and delayed infection in 1.Complete decompression and bone graft fusion are the key to treatment. Decompression and internal fixation improve the symptoms of patients with lumbar spinal stenosis associated with spondylolisthesis. Transpedicle instrumentation can reduce spondylolisthesis and maintain the physical curve of the lumbar.",
        "keywords": [],
        "authors": [
            {
                "name": "Hongguang Xu",
                "org": "Department Of Orthopaedics, Yijishan Hospital, Wannan Medical College, Anhui 241001, China."
            },
            {
                "name": "Yipeng Wang",
                "org": ""
            },
            {
                "name": "Guixing Qiu",
                "org": ""
            },
            {
                "name": "Jianguo Zhang",
                "org": ""
            },
            {
                "name": "Xinyu Yang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Qi Fei",
                "org": ""
            },
            {
                "name": "Qichun Zhao",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2002
    },
    "EqI8DXXz": {
        "id": "EqI8DXXz",
        "title": "Effect of preoperative brace treatment on the surgical correction results in female adolescent idiopathic scoliosis",
        "abstract": "Objectives: To analyze the effect of preoperative brace treatment on the surgical correction results in female adolescent idiopathic scoliosis(AIS).Methods: From July 2001 to December 2009,70 female patients with major thoracic(MT) curves and under going posterior corrective surgery in our hospital were studied retrospectively.The patients were classified into two groups: group A: with preoperative Boston brace treat ment(n=26),and group B: with no preoperative brace treatment(n=44).There were no significant differences with respect to the malformation found age,age at operation,preoperative coronal Cobb angle of the MT curve,Cobb angle on convex bending film,the flexibility of the MT curve and the vertebra included in the fusion range between the 2 groups(P>0.05).Twenty-three patients in group A and 34 patients in group B were followed up for at least 1 year,and the average follow-up time of the 2 groups was 37.7 months(range,12 to 101 months) and 28.7 months(range,12 to 87 months),respectively(P>0.05).The differences of the radiographic correction results of the MT curve between the 2 groups were evaluated.Results: The mean preoperative coronal Cobb angles of the MT curve of the 2 groups were 52.8° ±8.3° and 54.0° ±10.7°.After surgery,they were corrected to 12.3°±7.3° and 11.5°±8.1°,with an average correction rate of(77.0±12.6)% and(79.3±11.9)%,respectively(P>0.05).At final follow-up,they were 16.7°±8.4° and 15.4°±7.2°,with similar correction rate[(68.8±14.5)% vs.(70.5±13.0)%,P>0.05].The preoperative apical vertebral translation of the MT curve in 2 groups was 41.4±14.3mm and 36.8±13.7mm,respectively,without significant difference(P>0.05).After operation,they were corrected to 10.4±5.4mm and 7.2±5.6mm,and group B had a better correction(P< 0.05) than group A.At final follow-up,they were 14.4±11.3mm and 12.1±8.5mm,without significant difference(P>0.05).The decompensation occurrences of coronal trunk balance in group A and B were 15.4%(4/26) and 9.1%(4/44) preoperatively,15.4%(4/26) and 15.9%(7/44) postoperatively,and 4.3%(1/23) and 8.8%(3/34) at final follow-up,respectively,which showed no differences(P>0.05).The mean preoperative sagittal Cobb angles of the MT curve of the 2 groups were 12.9°±11.1° and 18.7°±11.3°,and group A had a less thoracic kyphosis(P<0.05) than group B.After surgery,the Cobb angles of thoracic kyphosis were corrected to 18.0°±6.3° and 22.3°±7.8°,with no significant difference(5.0°±9.8° and 3.6°±12.6°,P>0.05).At final follow-up,the sagittal Cobb angle of the MT curve was 20.0°±6.7° and 22.4°±7.7°,respectively(P>0.05).Conclusions: Preoperative brace treatment has no obvious impact on the correction results of the MT curve in female AIS patients.",
        "keywords": [
            "Brace",
            "Corrective surgery",
            "Main thoracic curve",
            "Effect",
            "Idiopathic scoliosis",
            "Female"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ", et al Department of Orthopedics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,,China"
            },
            {
                "name": "WANG Yipeng",
                "org": ", et al Department of Orthopedics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,,China"
            },
            {
                "name": "QIU Guixing",
                "org": ", et al Department of Orthopedics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,,China"
            }
        ],
        "venue": "Chinese Journal of Spine and Spinal Cord",
        "year": 2012
    },
    "A8f0yfli": {
        "id": "A8f0yfli",
        "title": "Distal junctional changes in adolescent idiopathic scoliosis following posterior correction",
        "abstract": "Objective:To investigate distal junctional changes on the coronal,saggital and axial plane in adolescent idiopathic scoliosis(AIS) undergoing posterior correction.Method:32 AIS cases from June 2005 to June 2007 undergoing surgery were reviewed retrospectively.There were 6 males and 26 females with an average age of 14.4 years(range,10 to 19 years old).The curve types included PUMCⅠc 1 case,Ⅱa 4 cases,Ⅱb 9 cases,Ⅱb2 1 case,Ⅱc1 1 case,Ⅱc3 5 cases,Ⅱd1 5 cases ,Ⅲa 5 cases,Ⅲb 1 case.All of them undergoing posterior correction using pedicle screw constructs alone were divided into 2 groups:group A,15cases,with the lowest instrumented vertebrae(LIV) of stable vertebrae(SV)(SV=LIV);group B,17cases,with LIV of not the stable vertebrae(SV≠LIV).Radiographic measurements from standing anterio-posterior and lateral radiographs before surgery and at final follow-up including trunk shift(TS),lowest instrumented vertebrae tilt(LIVT),distal disc angulation(LIVA),coronal and sagittal Cobb angle of distal junction(LIV+2),axial rotation of distal junction(LIV+1 vertebral rotation and LIV+2 vertebral rotation) were collected and analyzed.Result:The average follow-up was 29 months(range,24 to 36 months).There were no statistic difference in TS before surgery and at final follow-up in both groups(P>0.05).The LIVT was corrected from 20.2°±5.9° before surgery to 4.7°± 3.8° at final follow-up(P<0.001) in group A and 17.2°±5.5° to 4.4°±2.7°(P<0.001) in group B.The LIVA was corrected from 7.5°±4.7° before surgery to 3.9°±3.1° at final follow-up(P=0.056) in group A and 4.5°± 3.4° to 5.4°±3.2°(P=0.492) in group B.The LIVA change was not significantly correlated with the change of the LIVT in both group(group A:r=-0.067,P=0.813;group B:r=0.362,P=0.154).The coronal Cobb of LIV+2 improved significantly from 20.5°±9.6° before surgery to 9.4°±7.3° at final follow-up(P<0.001) in group A and 13.8°±6.7° to 8.1°±4.7°(P=0.013) in group B.There was no significant difference in saggital curve correction of LIV+2 in both groups(group A:P=0.464,group B:P=0.598).The correlation of saggital curve correction was not significant in group A(r=0.076,P=0.788) while significant in group B(r=0.803,P<0.001).There were no significant difference of LIV+2 curve axial correction in both groups(P>0.05).Conclusion:The distal junctional correction for AIS due to pedicle screw fixation is more significant on the coronal plane rather than the sagittal plane and axial plane,meanwhile the lowest instrumented vertebrae tilt is decreased after surgery.",
        "keywords": [
            "Posterior cprrection",
            "Distal junctional changes",
            "Pedicle screw",
            "Adolescent idiopathic scoliosis"
        ],
        "authors": [
            {
                "name": "XING Zejun",
                "org": ",et al Department of Orthopaedics,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,,China"
            },
            {
                "name": "ZHANG Jianguo",
                "org": ",et al Department of Orthopaedics,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al Department of Orthopaedics,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,,China"
            }
        ],
        "venue": "Chinese Journal of Spine and Spinal Cord",
        "year": 2010
    },
    "nUCgrzZo": {
        "id": "nUCgrzZo",
        "title": "The efficacy and complications of posterior hemivertebra resection with monosegmental fusion for congenital scoliosis]",
        "abstract": "To evaluate the efficacy and complications of posterior hemivertebra resection with monosegmental fusion in the treatment of congenital scoliosis.Thirty consecutive cases of congenital scoliosis managed by posterior hemivertebra resection with monosegmental fusion of the two adjacent vertebra were investigated retrospectively. Radiographs were reviewed to determine the coronal curve magnitude and sagittal alignment preoperatively, postoperatively and at last follow-up. Operative reports and patient charts were reviewed to record any perioperative and late complications.The total number of resected hemivertebra was 30. Mean operation time was 193.8 min with average blood loss of 369.0 ml. The segmental scoliosis was corrected from 36.4° to 4.9° with a correction rate of 86.5%, and segmental kyphosis (difference to normal segmental alignment) from 21.2° to 6.6° with a correction rate of 68.9%. The trunk shift was improved from 17.1 to 8.8 mm. The correction of the compensatory cranial and caudal curve were 74.9% and 75.1%. There were 1 delayed wound healing, 2 pedicle cutting and 1 rod breakages. Radiolucent gaps were found on the lateral view in 2 cases without any sign of implant failure and correction loss.Posterior hemivertebra resection with monosegmental fusion of the two adjacent vertebra allows for early intervention in very young children. Excellent correction in the frontal and sagittal planes can be obtained. And a short segment of fusion allows for normal growth in the unaffected parts of the spine. The most common complication is implant failure.",
        "keywords": [],
        "authors": [
            {
                "name": "Sheng-ru Wang",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China."
            },
            {
                "name": "Jian-guo Zhang",
                "org": ""
            },
            {
                "name": "Gui-xing Qiu",
                "org": ""
            },
            {
                "name": "Shu-gang Li",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2011
    },
    "s9obJoPT": {
        "id": "s9obJoPT",
        "title": "Posterior hemivertebra resection in the treatment of congenital kyphoscoliosis",
        "abstract": "Objective To evaluate the surgical results of posterior hemivertebra resection in the treatment of congenital kyphoscoliosis caused by fully segmented hemivertebra. Methods A total of 18 patients with fully segmented hemivertebra treated with one stage posterior hemivertebra resection were reviewed, which included 7 males and 11 females. All the patients underwent one stage posterior hemivertebra resection, fusion and correction with instrumentation. The average age at surgery was 11.3 years old. Location of the hemivertebra included 8 cases at thoracic spine and 10 cases at lumbar spine. The instrumentation included CDH in 2 cases, TSRH in 2 cases, ISOLA in 8 cases and Moss-Miami in 6 cases. Mesh cage was used in 4 cases. Results The average operation time was 5.5 hours, the mean blood loss and blood transfusion during operation was 918 ml and 850 ml respectively. The mean fusion level was 2 to 8 segments, average 3.7 segments. Scoliosis was corrected from 42.11° to 14.25° with a correction rate of 66.40%. Kyphosis was corrected from 49.30° to 14.12° with a correction rate of 69.98%. Apical vertebral translation was improved from 26.94 mm to 11.06 mm. At the final follow-up, the coronal Cobb angle was 19.39° with a 5.14° loss of correction; the sagittal Cobb angle was 14.80°, minor loss of correction was noted. No pseudoarthrosis and implant failure was noted. Peri-operative complication included one delayed wound healing, one revision due to loosening of pedicle screw. There was no neurological complication. Conclusion One stage posterior hemivertebra resection has a good capability of correcting congenital kyphoscoliosis caused by a single hemivertebra. It can save operation time and is less invasive compared with combined approach, and is indicated to thoracic and lumbar hemivertebre with few complication.",
        "keywords": [
            "Scoliosis",
            "Internal fixators",
            "Spinal fusion",
            "Kyphosis"
        ],
        "authors": [
            {
                "name": "ZHANG Jian-guo",
                "org": ", et al. Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Acadamy of Medical Sciences & Peking Union Medical College, Beijing , China"
            },
            {
                "name": "QIU Gui-xing",
                "org": ", et al. Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Acadamy of Medical Sciences & Peking Union Medical College, Beijing , China"
            },
            {
                "name": "YU Bin",
                "org": ", et al. Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Acadamy of Medical Sciences & Peking Union Medical College, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Orthopaedics",
        "year": 2006
    },
    "vitr6sXN": {
        "id": "vitr6sXN",
        "title": "Selective thoracic fusion in treating PUMC type Ⅱ adolescent idiopathic scoliosis",
        "abstract": "Objectives To evaluate the effectiveness of selective thoracic fusion in treating adolescent patients wiht PUMC typeⅡidiopathic scoliosis.Methods We retrospectively reviewed the roentgenograms of adolescent idiopathic scoliosis patients undergoing selective thoracic fusion.The curve type,Cobbs,angle,flexibility,apical rotation and translation,trunk shift,and thoracolumbar kyphosis were measured and analyzed.Results There were 20 PUMC typeⅡb1 and 5 PUMCⅡC3.The coronal Cobb's angle of thoracic curve before and after surgery were 48.0°and 14.3°,respectively, and the average correction rate was 70.0%.The coronal Cobb's angle of lumbar curve before and after surgery were 32.2°and 11.9°respectively,and the average spontaneous correction rate was 62.9%.No trunk decompensation was noted at final follow-up.Conclusions Selective thoracic fusion can be safely and effectively performed in patients with a moderate and flexible lumbar curves using criteria of PUMC classification,which can save more mobile segments to maintain a good coronal and sagittal balance.",
        "keywords": [
            "scoliosis",
            "thoracic vertebrae",
            "spinal fusion",
            "classification"
        ],
        "authors": [
            {
                "name": "YU Ke-yi",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "QIU Gui-xing",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "WANG Yi-peng",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "ZHANG Jian-guo",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "SHEN Jian-xiong",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "ZHAO Hong",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "ZHAO Yu",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "LI Shu-gang",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            },
            {
                "name": "YANG Xin-yu",
                "org": "Department of Orthopaedic,PUMC Hospital,CAMS/PUMC,Beijing ,China"
            }
        ],
        "venue": "Chinese Bone and Joint Surgery",
        "year": 2008
    },
    "DvqDldkG": {
        "id": "DvqDldkG",
        "title": "Effect of preoperative brace treatment on the mental health scores of SRS-22 and SF-36 questionnaire in surgically treated adolescent idiopathic scoliosis patients.",
        "abstract": "Retrospectively study.To analyze whether there were differences of mental health scores of Scoliosis Research Society-22(SRS-22) questionnaire and Short Form-36(SF-36) questionnaire between adolescent idiopathic scoliosis (AIS) patients with/without preoperative brace treatment.Mental health is an important domain of SRS-22 and SF-36 questionnaire. There are few studies focused on the effect of preoperative brace treatment on the mental health in surgically treated AIS patients.The SRS-22 and SF-36 questionnaires of 211 AIS patients who underwent posterior correction surgery were retrospectively reviewed. The average age of the patients was 14.4 years old (range, 11 to 18), and the patients were classified into 2 groups: with preoperative brace treatment (group BS-32 cases, 5 males and 27 females) and without preoperative brace treatment (group S-179 cases, 23 males and 156 females). Compare the radiographic data and mental health scores of SRS-22 and SF-36 questionnaires between the 2 groups.There was no significant difference in terms of height, rib hump, the mean preoperative coronal Cobb angle or apical vertebral translation of the major curve, sagittal thoracic kyphosis or coronal trunk balance between group BS and group S (all P>0.05). The average and total mental health scores of SRS-22 between group BS and group S were 3.6±0.7 and 3.7±0.5, and 18.1±3.5 and 18.3±2.6, respectively. The total mental health scores of SF-36 between group BS and group S were 71.1±8.7 and 68.7±11.5, respectively. There was none significant difference of the mental health scores of SRS-22 and SF-36 questionnaires between group BS and group S (all P>0.05).Preoperative brace treatment didn't have obvious influence on the mental health scores of SRS-22 and SF-36 questionnaires in surgically treated AIS patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100730,China."
            },
            {
                "name": "Yipeng Wang",
                "org": ""
            },
            {
                "name": "Guixing Qiu",
                "org": ""
            },
            {
                "name": "Jianxiong Shen",
                "org": ""
            },
            {
                "name": "Jianguo Zhang",
                "org": ""
            }
        ],
        "venue": "Journal of spinal disorders & techniques",
        "year": 2013
    },
    "EzzruFin": {
        "id": "EzzruFin",
        "title": "Development of proximal thoracic curve evaluation scale in adolescent idiopathic scoliosis patients",
        "abstract": "Objectives To develop an objective scale to evaluate the proximal thoracic(PT)curve parameters in adolescent idiopathic scoliosis patients and then using this scale to define when to fuse the PT curve.Methods Five spine surgeons retrospectively reviewed the radiographs of the patients with a PT curve in the database.The coronal Cobb angle,Cobb angle on side bending film,sagittal Cobb angle and radiographic shoulder height difference(RSH)were measured.Different scores(0 to 3)were assigned to different measured values of these items,thus developed a scale. Calculated the score of each item score and total score of all the items within the scale,and setting the threshold score of each item and total score of all the items as when to fuse the PT curve.Scores were evaluated,followed by collected data analysis in terms of inter-observer reliability.Three weeks later,reorganizing the cases in a new randomized order,reviewers then repeated individual measurement processes,followed by intra-observer reliability analysis.Kappa coefficient was calculated to test the inter-observer reliability and intra-observer reproducibility.Results The mean score of the coronal Cobb angle,Cobb angle on side bending film,RSH,and sagittal Cobb angle of the PT curve were 2.4 points,2.4 points,0.2 points,and 1.1 points.The mean total score of the scale was 6.0 points.The inter-observer reliability and intra-observer reproducibility of the scale were 79.3%(Kappa coefficient 0.77)and 79.3%(Kappa coefficient 0.77) for total score,89.7%(Kappa coefficient 0.89)and 82.8%(Kappa coefficient 0.81)for coronal Cobb angle,86.2% (Kappa coefficient 0.85)and 89.7%(Kappa coefficient 0.89)for Cobb angle on side bending film,96.6%(Kappa coefficient 0.95)and 93.1%(Kappa coefficient 0.92)for RSH,96.6%(Kappa coefficient 0.95)and 96.6%(Kappa coefficient 0.95)for sagittal Cobb angle.According to the scale,we defined PT curve fusion if the score of the single item was 3 points or a total score was at least 4 points.The inter-observer reliability and intra-observer reproducibility of using this method to decide when to fuse the PT curve were 96.6%(Kappa coefficient 0.95)and 96.6%(Kappa coefficient 0.95).Conclusions The inter-observer reliability and intra-observer reproducibility of the scale is appropriate to evaluate PT curve and decide fusion timing.",
        "keywords": [
            "Scoliosis",
            "Proximal thoracic curve",
            "Reliability",
            "Reproducibility",
            "Scale"
        ],
        "authors": [
            {
                "name": "QIU Gui-xing",
                "org": ",et al.Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC, Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC, Beijing ,China"
            },
            {
                "name": "WANG Yi-peng",
                "org": ",et al.Department of Orthopedics,Peking Union Medical College Hospital,CAMS & PUMC, Beijing ,China"
            }
        ],
        "venue": "Chinese Bone and Joint Surgery",
        "year": 2008
    },
    "brlzUqnH": {
        "id": "brlzUqnH",
        "title": "Determination of Flavor Esters in Enzymatically Transformed Coconut Oil: FLAVOR ESTER ANALYSIS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jingcan sun",
                "org": ""
            },
            {
                "name": "jin hua chin",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": ""
            }
        ],
        "venue": "Journal of Food Biochemistry",
        "year": 2013
    },
    "HWAfXDPx": {
        "id": "HWAfXDPx",
        "title": "Mango wine aroma enhancement by pulp contact and β-glucosidase",
        "abstract": "This study determined the influence of pulp maceration and β-glucosidase on mango wine physico-chemical properties and volatile profiles. The distinction in pH, sugars and organic acids among different treatments was not statistically significant. All wine samples reached around 8% (v/v) ethanol from about 16% (w/v) of sugars. The wine with pulp contact contained about ten times higher α-terpinolene and up to three times higher acetate esters than the wine without pulp contact, but mitigated the production of medium-chain fatty acids and relative ethyl esters by up to six times. β-glucosidase enhanced terpenols by up to ten times and acetate esters by up to three times. Furthermore, enzyme treatment mitigated, by up to five times, the formation of medium-chain fatty acids and ethyl esters to moderate levels. Sensory evaluation showed pulp contact, and β-glucosidase not only improved the intensity and complexity of wine aroma but balanced odour attributes. © 2013 Institute of Food Science and Technology.",
        "keywords": [
            "β-glucosidase",
            "flavour",
            "juice",
            "mango wine",
            "pulp",
            "volatiles"
        ],
        "authors": [
            {
                "name": "Xiao Li",
                "org": "National University of Singapore(National University of Singapore),Singapore City,Singapore"
            },
            {
                "name": "Sienlong Lim",
                "org": "National University of Singapore(National University of Singapore),Singapore City,Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Firmenich Asia Pte Ltd(Firmenich Asia Pte Ltd,Firmenich Asia Pte. Ltd.),Singapore City,Singapore"
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte Ltd(Firmenich Asia Pte Ltd,Firmenich Asia Pte. Ltd.),Singapore City,Singapore"
            },
            {
                "name": "Shaoquan Liu",
                "org": "National University of Singapore(National University of Singapore),Singapore City,Singapore"
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2013
    },
    "RZPhHOMm": {
        "id": "RZPhHOMm",
        "title": "Evolution of volatile compounds in papaya wine fermented with three Williopsis saturnus yeasts",
        "abstract": "",
        "keywords": [
            "fermentation",
            "volatiles"
        ],
        "authors": [
            {
                "name": "pinrou lee",
                "org": "national university of singapore"
            },
            {
                "name": "yuenling ong",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2010
    },
    "vebukM2n": {
        "id": "vebukM2n",
        "title": "Volatile composition and antioxidant capacity of Arabica coffee",
        "abstract": "",
        "keywords": [
            "volatiles"
        ],
        "authors": [
            {
                "name": "mun wai cheong",
                "org": ""
            },
            {
                "name": "kau hin tong",
                "org": ""
            },
            {
                "name": "jeremy jian ming ong",
                "org": ""
            },
            {
                "name": "shao quan liu",
                "org": ""
            },
            {
                "name": "phillip curran",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Food Research International",
        "year": 2013
    },
    "BCBmvIXQ": {
        "id": "BCBmvIXQ",
        "title": "Comparative analysis of pomelo volatiles using headspace-solid phase micro-extraction and solvent assisted flavour evaporation",
        "abstract": "Abstract   In this work, headspace solid-phase microextraction (HS-SPME) was applied for a comparative study of the volatile profiles of flower, leaf, peel and juice from Malaysia pomelo. Different volatile profiles were observed in these different plant parts based on the analytical results obtained from HS-SPME analysed by gas chromatography-mass spectrometry coupled with a flame ionisation detector (GC-MS/FID). Pomelo peel contained the greatest abundance of volatiles, followed by the leaf, flower and juice. Moreover, the temperature parameters for solvent assisted flavour evaporation (SAFE) were systematically optimised using pomelo juice. The optimised water bath temperature was 20 ± 0.5 °C and condenser temperature was 20 ± 0.1 °C. In general, separation of pomelos by country was observed by principal component analysis (PCA). From the PCA loadings plot, compounds such as citronellol and α-terpineol were identified as contributors to separation in HS-SPME peel and juice respectively, while nootkatone was identified in SAFE extracts. Finally, the sugar and organic acid content of the pomelos were measured by high performance liquid chromatography (HPLC).",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Min Vivian Goh",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, 117542, Singapore"
            },
            {
                "name": "Hazel Lau",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, 138623, Singapore"
            },
            {
                "name": "Shao-Quan Liu",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, 117542, Singapore"
            },
            {
                "name": "Benjamin Lassabliere",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, 138623, Singapore"
            },
            {
                "name": "Rozenn Guervilly",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, 138623, Singapore"
            },
            {
                "name": "Jingcan Sun",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, 138623, Singapore"
            },
            {
                "name": "Yulan Bian",
                "org": "Agilent Technologies Singapore (Sales) Pte Ltd, 1 Yishun Avenue 7, 768923, Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, 138623, Singapore"
            }
        ],
        "venue": "Lwt - Food Science and Technology",
        "year": 2019
    },
    "f2hUErUq": {
        "id": "f2hUErUq",
        "title": "Identification of Aroma-Active Compounds in Malaysian Pomelo (Citrus grandis (L.) Osbeck) Peel by Gas Chromatography-Olfactometry",
        "abstract": "Malaysian pink and white pomelo (Citrus grandis (L.) Osbeck) peels were extracted with dichloromethane (DCM). Using GC-FID/MS and gas chromatography-olfactometry (GC-O), 50 and 47 omit a-active compounds were identified in pink and white pomelo peel extracts, respectively. The potency of each odorant hi both pomelo peel extracts was determined by aroma extraction dilution analysis (AEDA). On the basis of flavor dilution (m) factor, odor activity value (OAV) and relative flavor activity (RFA), main odorants in pink pomelo peel extract were trans-linalool oxide, cis,trans-2,6-nonadienal, octanal, citronellal, nonanal, trans-nerolidol, neryl acetate, indole, 6-methyl-5-hepten-2-one, terpinolene, trans-2-heptenal, perilla alcohol and nootkatone, while the most intense aromas in white pound peel extract were terpinolene, alpha-copaene, 4-terpinenol, trans-nerolidol, trans-linalool oxide, nootkatone, cis,trans-2,6-nonadienal, citronellol, elemol, carvyl acetate, 6-methyl-5-hepten-2-one, perilla aldehyde and indole. Thus, no single compound exhibited the characteristic aroma of both Malaysian pomelo peel extracts.",
        "keywords": [
            "Pomelo",
            "GC-olfactometry",
            "AEDA",
            "RFA",
            "aldehydic",
            "grapefruit-like"
        ],
        "authors": [
            {
                "name": "mw cheong",
                "org": "Natl Univ Singapore, Food Sci & Technol Programme, Dept Chem, Singapore 117543, Singapore"
            },
            {
                "name": "sq liu",
                "org": "Natl Univ Singapore, Food Sci & Technol Programme, Dept Chem, Singapore 117543, Singapore"
            },
            {
                "name": "junseok yeo",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            },
            {
                "name": "hk chionh",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            },
            {
                "name": "k pramudya",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            },
            {
                "name": "philip curran",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            },
            {
                "name": "bin yu",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            }
        ],
        "venue": "JOURNAL OF ESSENTIAL OIL RESEARCH",
        "year": 2011
    },
    "dmCdvdVE": {
        "id": "dmCdvdVE",
        "title": "Influence of Saccharomyces cerevisiae and Williopsis saturnus var. Mrakii on mango wine characteristics",
        "abstract": "Saccharomyces cerevisiae MERIT. ferm was used as mono- and mixed-cultures with Williopsis saturnus var. mrakii NCYC500 in mango wine fermentation. A ratio of 1: 1000 (Saccharomyces: Williopsis) was chosen for mixed-culture fermentation to enable longer persistence of the latter. The monoculture of S. cerevisiae and mixed-culture was able to ferment to dryness with 7.0% and 7.7% ethanol, respectively. The monoculture of W. mrakii produced 1.45% ethanol. The mango wines fermented by S. cerevisiae alone and the mixed-culture were more yeasty and winey, which reflected their higher amounts of fusel alcohols, ethyl esters and medium-chain fatty acids. The mango wine fermented by W. mrakii alone was much less alcoholic, but fruitier, sweeter, which corresponded to its higher levels of acetate esters.",
        "keywords": [
            "flavour"
        ],
        "authors": [
            {
                "name": "x li",
                "org": "Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, Singapore 117543, Singapore"
            },
            {
                "name": "lawrence chan",
                "org": "Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, Singapore 117543, Singapore"
            },
            {
                "name": "bin yu",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            },
            {
                "name": "philip curran",
                "org": "Firmenich Asia Pte Ltd, Singapore 638377, Singapore"
            },
            {
                "name": "s q liu",
                "org": "Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, Singapore 117543, Singapore"
            }
        ],
        "venue": "Acta Alimentaria",
        "year": 2014
    },
    "t4kUkbAm": {
        "id": "t4kUkbAm",
        "title": "Quantitative analysis of volatiles in transesterified coconut oil by headspace-solid-phase microextraction-gas chromatography–mass spectrometry",
        "abstract": "A simple and fast headspace-solid-phase microextraction (HS-SPME) method coupled with gas chromatography–mass spectrometry (GC–MS) was developed for the analysis of volatile compounds in transesterified coconut oil by applying solvent dilution. Solvent dilution conditions (solvent type and solvent amount) and HS-SPME sampling parameters (adsorption temperature and time) were optimised through monitoring the adsorption result of the selected volatiles (octanoic acid esters) in transesterified coconut oil samples. The incubation of methanol (800 μl)-diluted oil (200 μl) sample at 60 °C for 30 min led to the best result. The method was further validated by determining the calibration linear range, correlation coefficient ( R 2 ), accuracy, precision, limit of detection and limit of quantification through spiking standards into the blank matrix consisting of coconut oil and methanol. This method may also be applicable for detection and determination of volatile compounds in other transesterified oil samples. Keywords Coconut oil Fusel alcohols Fatty acid esters HS-SPME Solvent dilution 1 Introduction Biocatalysis is a promising natural flavour production technique, which normally applies enzymes to catalyse the flavour generation reactions ( Longo & Sanromán, 2006 ). Lipases, as one class of biocatalysts, are capable of catalysing the reactions to produce fatty acid esters especially short-chain fatty acid (C4–C8) esters which are commonly used as the flavouring agents in food industry because of their fruity flavour notes ( Liu, Holland, & Crow, 2004 ). Lipase-catalysed esterification and transesterification are two alternative methods that are used to produce desirable fatty acid esters by selecting suitable alcohols and fatty acids or triglycerides with preferable fatty acid profiles as the substrates ( Güvenç, Kapucu, & Mehmetoğlu, 2002; Lubary, ter Horst, Hofland, & Jansens, 2008 ). In particular, a concentrated mixture of fatty acid esters can be obtained through the transesterification of vegetable oils in solvent-free systems. Coconut oil and coconut cream are two products of coconut palm ( Cocos nucifera ) which is the plant growing throughout the tropic countries. Coconut cream has been reported as the substrate for the production of natural aroma-active 2-phenylethyl esters via biocatalysis because of its high content of octanoic acid (C8) ( Tan, Yu, Curran, & Liu, 2011 ). Similarly, coconut oil also contains a substantial amount of octanoic acid (above 8% w/w) ( Benjapornkulaphong, Ngamcharussrivichai, & Bunyakiat, 2009; Peng, Yang, & Ding, 1991 ). In the South-East Asia, coconut oil is a low-cost and readily available vegetable oil and shows the potential to be utilised as the sustainable substrate for natural flavour ester production, especially octanoic acid esters. However, to the best of our knowledge, except for being used as the substrate for biodiesel fuel production ( Jitputti et al., 2006; Oliveira et al., 2010 ), little research has been conducted on its utilisation as a natural flavour ester production substrate. After transesterification, the viscous oil sample contains various components that make direct instrumental analysis difficult. Due to the lack of need for sample preparation, near infrared spectroscopy (NIR) is reported as a feasible method for monitoring the esterification process ( Blanco, Zamora, Mir, & Mulero, 2009 ), and may be suitable for some targeted analyses. For exploring and quantifying compounds in the complex samples, an effective and efficient sample preparation method is critical. Several oil sample preparation methods have been reported such as solvent extraction, supercritical fluid extraction and solid-phase extraction ( Jones, Watson, Meredith, Chen, & Bennett, 2001; Perretti et al., 2007 ). However, they show drawbacks such as requiring large amounts of solvents and samples, being laborious and tedious, time-consuming, high cost and showing a possibility of sample loss due to multiple-step procedures. Headspace-solid-phase microextraction (HS-SPME) is a simple, solvent-free method that integrates sample preparation, sample concentration and sample introduction in one step to reduce sample loss and sample contamination ( Pawliszyn, Pawliszyn, & Pawliszyn, 1997 ); additionally, it can be easily automated to significantly improve sampling efficiency. HS-SPME has been applied in trace-level detection of off-flavours, contaminants ( Page & Lacroix, 2000 ) and volatile compounds in oils ( Doleschall, Recseg, Kemény, & Kővári, 2003 ). The quantitative analysis of volatile compounds by HS-SPME in the food samples with complex matrices is challenged by the limited fibre coating capacity which may lead to fibre saturation and the competitive adsorption between different volatile components ( Contini & Esti, 2006 ). Particularly, the matrix of transesterified oil samples is even more complicate than regular foods, because these oil-based samples contain not only fatty acid esters, but also residual reagents and reaction intermediates with high boiling points, such as alcohols, free fatty acids, monoglycerides, diglycerides and glycerol ( Szczesna Antczak, Kubiak, Antczak, & Bielecki, 2009 ). Among these components, residual alcohol reagents may cause displacement effects on flavour esters and further introduce prejudice on quantitative determination of target ester compounds. The high viscosity of oil samples also influences the HS-SPME extraction efficiency. To obtain repeatable and reliable quantitative data by minimising matrix effects, solvent dilution has been suggested by several studies. For example, diluting sample with water has been used to overcome the limitations in shampoo perfume analysis with SPME ( Chen, Begnaud, Chaintreau, & Pawliszyn, 2006 ), through which the shampoo viscosity was decreased and the concentration of free analytes in the headspace was increased. Additionally, organic solvent has also been used to minimise matrix effects during trace-level analysis of phthalic acid esters (contaminants) in vegetable oils through facilitating the transfer of low-vapour pressure analytes from the oil phase into the headspace ( Holadová, Prokupková, Hajslová, & Poustka, 2007 ). However, little research has been done on the effectiveness of solvent dilution method for HS-SPME quantitative analysis of volatile compounds at high concentrations in oil samples. Therefore, the objective of this work was to develop a HS-SPME method for the quantitative analysis of volatile compounds (especially fatty acid esters) in transesterified coconut oil samples using a GC–MS system. To achieve this objective, solvent dilution conditions (solvent type and solvent amount) applied for matrix modification and the HS-SPME sampling parameters (adsorption temperature and time) were optimised. Finally, the developed quantitative analysis method for the determination of volatile compounds in oil samples was validated. 2 Materials and methods 2.1 Materials and reagents Coconut oil (PGEO Edible Oils Sdn. Bhd, Pasir Gudang, Malaysia) and fusel alcohols (Firmenich Asia Pte. Ltd., Singapore) were used as the substrates for production of fatty acid esters through transesterification catalysed by Lipozyme TL IM (Novozymes, Bagsværd, Denmark). Standards used in the experiments such as ethyl octanoate (EO) (>98%) and ethyl nonanoate (internal standard >98%) were provided by Firmenich Asia Pte. Ltd. (Singapore). Isobutyl octanoate (IBO) (>99%) and butyl octanoate (BO) (>99%) were obtained from Tokyo Chemical Industry Co. Ltd. (Tokyo, Japan). Isoamyl octanoate (IAO) (>98%) was purchased from Sigma–Aldrich Fine Chemicals (St. Luis, MO, USA). Internal standard of 2-methyl-5-hexanone (>98%) used for determining the composition of fusel alcohols was purchased from Sigma–Aldrich (Steinheim, Germany). A C8–C40 n -alkane hydrocarbon standard mixture from Fluka (Buchs, Switzerland) was applied in determining retention indices. Methanol and hexane used in this study were of analytical grade. 2.2 Transesterification of coconut oil with fusel alcohols Fusel alcohols (also known as fusel oil) containing primary and secondary alcohols ( Nemestóthy, Gubicza, Fehér, & Bélafi-Bakó, 2008 ) were employed as the alcohol substrate for the transesterification reaction. To quantify the amounts of major alcohols in the fusel alcohols used, 2-methyl-5-hexanone was applied as internal standard for relative response factor calculation. Since isoamyl alcohol and active amyl alcohol in the fusel alcohols could not be well separated under the GC conditions used in this study, they were determined together as (iso)amyl alcohol. The determined alcohol composition of the fusel alcohols is shown in Table 1 . Coconut oil (20.0 g), fusel alcohols (8.0 ml) and Lipozyme TL IM (2.0 g) were added into a 100-ml screw-capped glass bottle, followed by incubation at 40 °C in water bath and samples were collected at different times for HS-SPME-GC–MS/FID analysis. 2.3 Standard solution preparation A standard stock solution containing EO (1750 ppm), IBO (3480 ppm), BO (90 ppm) and IAO (5200 ppm) was prepared by dissolving each of the four standards into methanol. The standard stock solution was mixed thoroughly using a vortex mixer and stored at 4 °C. The internal standard stock solution (8720 ppm) was prepared by accurately measuring 100 μl of ethyl nonanoate and dissolving into 10 ml of methanol. Twenty microlitres of the internal standard solution were added into each sample vial for analysis with a final concentration of 174 ppm. Standard solutions used for establishing calibration curves were prepared in blank matrix consisting of coconut oil (20%) and methanol (80%). The final concentrations of the four ester standards are shown in Table 2 . 2.4 HS-SPME procedure and optimisation The HS-SPME apparatus used was an integrated automated sampling system consisting of a CTC SPME auto sampler, a shaking incubator, a fibre conditioner, and a 32 vial tray holder (Gerstel, Germany). The adsorption of volatile compounds was carried out with a 85 μm carboxen-polydimethylsiloxane (CAR-PDMS) fibre (Supelco, Bellefonte, PA, USA). CAR-PDMS fibre has been reported to be an effective fibre for the adsorption of a wide range of esters ( Antalick, Perello, & de Revel, 2010 ). The fibre was exposed to a SPME vial containing oil samples and internal standard and incubated in an automated shaking incubator (250 rpm) for adsorption. Then, the fibre was desorbed for 2.5 min in the injector port. The post injection fibre cleaning was conducted by injecting the fibre into another heated incubator for 5 min to avoid carry-over. Effectiveness of matrix modification with different solvents, including water, methanol and hexane, on HS-SPME efficiency and repeatability was investigated. HS-SPME parameters were optimised by conducting single-factor experiments and the extractions were carried out at varied adsorption temperatures (40, 50, 60, 70 °C) and adsorption times (20, 30, 40, 50 min). All tests were performed in triplicate to calculate the mean, standard deviation (SD) and relative standard deviation (RSD) values. 2.5 GC–MS analysis The adsorbed volatiles were analysed using an Agilent (Palo Alto, CA, USA) 6890 N network gas chromatography system equipped with a DB-FFAP capillary column (60 m × 0.25 mm × 0.25 μm, Agilent, Woodbridge, USA), 5975 inert mass selective detector (MSD) and flame ionisation detector (FID). Purified helium was used as carrier gas with flow rate of 1.2 ml min −1 . The initial oven temperature was set at 50 °C for 5 min, then was ramped to 230 °C at 5 °C min −1 and kept for 30 min. Under the present conditions, the GC temperature programme was chosen for transesterified coconut oil analysis to achieve better resolutions of major peaks and to avoid column carry-overs caused by less volatile components (e.g. long-chain fatty acids). For the relatively clean sample matrix, the analysis time could be decreased. Split mode with a split ratio of 20:1 was applied. Both injector and detector temperatures were 250 °C. The FID peak area was used to monitor the uptake of analytes by the fibre. The volatile compounds in transesterified coconut oil samples were identified by comparing their mass spectra and retention indices with WILEY database or standards (or information from the literature). 2.6 Method validation Linearity was studied through constructing calibration curves with ester standard solutions at seven concentrations. The calibration curves were constructed by plotting the ratios of the peak area of respective standards to the peak area of the internal standard against the standard concentration. The limit of detection (LOD) was estimated as the concentration of the analyte that produced a signal to noise ratio of 3, which was 3SD/ b , where SD was the standard deviation of the lowest concentration in the calibration curve, b was the slope of regression line ( Esteve-Turrillas, Pastor, & Guardia, 2005 ). The limit of quantification (LOQ) was estimated as the concentrations of target compounds that provided a signal to noise ratio of 10, which was 10SD/ b . Accuracy was evaluated by determining the recovery rates through testing six quality control samples spiked with certain amounts of esters standards ( Table 2 ) and internal standard (174 μg). The original analyte concentrations in the quality control samples used for recovery tests were as follows: 86 ppm of EO, 159 ppm of IBO, 6 ppm of BO, 453 ppm of (i)AO. To evaluate the effectiveness of the developed method for quantitative analysis of volatile esters at two concentrations, the samples used for precision (CV, coefficient of variation) evaluation were prepared by spiking standards in blank matrix and the analyte concentrations were as follows: 500 and 100 ppm of EO, 800 and 160 ppm of IBO, 20 and 4 ppm of BO, 1500 and 300 ppm of IAO, and 174 ppm of the internal standard. Intraday precision was determined by analysing five replicate samples, and interday precision was examined by analysing five replicate samples over 5 days. 3 Results and discussion 3.1 Transesterification of coconut oil Coconut oil contains relatively abundant amount of octanoic (C8) acid and other fatty acids such as hexanoic (C6), decanoic (C10), dodecanoic (C12), tetradecanoic (C14) and hexadecanoic (C16) acids ( Benjapornkulaphong et al., 2009 ). After lipase-catalysed transesterification of coconut oil with fusel alcohols, a wide range of fatty acid esters including ethyl, propyl, butyl, isobutyl, amyl and isoamyl esters of short-, medium- and long-chain fatty acids were produced ( Fig. 1 ). Unlike short-chain C6 and C8 fatty acid esters, medium- and long-chain fatty acid esters normally impart less desirable odours. Hence, in this study we focused on the quantitative analysis of the predominant octanoic acid esters in the transesterified coconut oil samples. Isoamyl and active amyl octanoate have similar chemical properties that make it difficult to completely separate them under the current GC conditions. Therefore, the two esters were determined together and were referred to as (iso)amyl octanoate [(i)AO]. The time-course production of octanoic acid esters during transesterification of coconut oil with fusel alcohols is shown in Fig. 2 . The target esters were not found in blank coconut oil, but trace levels of (i)AO and EO were found in the control sample (coconut oil and fusel alcohols mixture without enzyme), which were from the fusel alcohols ( Ceylan, 1998 ). The reaction equilibrium was reached at 20 h for (i)AO and at 10 h for other esters ( Fig. 2 ). This may be due to the different amounts of alcohols present in the fusel alcohols used ( Table 1 ): the higher the amount, the longer time it may take for the reaction to complete. It is interesting to note that the production of octanoic acid esters paralleled that of octanoic acid, which indicated that water in fusel alcohols had participated in the hydrolysis of triglycerides to form free fatty acids. 3.2 Matrix modification Through solvent dilution, the matrix components will be diluted to a suitable concentration to prevent the displacement effect caused by the residual reagents especially alcohols. At the same time, fibre overloading is expected to be solved through diluting oil samples to reduce headspace concentrations of analytes. The intermolecular interaction between the volatile compounds and the matrix indicated by the activity coefficients will be changed through modifying the matrix with solvent ( Kolb & Ettre, 2006 ) and furthermore, the headspace sensitivity and reproducibility may also be affected. Higher solubility of volatile compounds in the solvent will result in higher partition coefficients and lower headspace sensitivity. For example, in transesterified coconut oil samples, the apolar volatile compounds such as octanoic acid esters ( Antalick et al., 2010 ) and major secondary alcohols (isobutyl alcohol and amyl alcohols) with poor solubility in water showed increased headspace concentrations (data not shown). Hence, the competitive displacement effects caused by secondary alcohols and fibre overloading were not eliminated by using water to dilute oil sample. On the other hand, poor repeatability was also observed, which may due to the emulsion formed during high speed shaking (250 rpm). In contrast to water, hexane as a non-polar solvent can completely dissolve transesterified coconut oil, which was responsible for the reduced FID peak areas of the octanoic acid esters [ Fig. 3 (a) and (b)]. Even though using hexane to modify the oil matrix could overcome fibre overloading, the headspace sensitivity may not be sufficient for quantitative analysis of volatile compounds with small quantities such as propyl octanoate (PO) and butyl octanoate (BO) [ Fig. 3 (b)]. Methanol with a polarity higher than hexane and lower than water was found to selectively dissolve the polar and non-polar components of transesterified oil. For example, in methanol most volatile compounds show better solubility than glycerol and triglycerides, which may facilitate the separation of octanoic acid esters from the non-polar oil matrix to the solvent phase and further increase the concentration in the headspace. The FID peak areas of target esters were higher in methanol than in hexane [ Fig. 3 (a) and (b)], which indicates that using methanol to dilute oil samples cannot only solve fibre overloading, but also provide sufficient signals for quantitative analysis of the analytes. Hence, methanol was selected as the solvent for matrix modification. The results demonstrated that solvent type determined the effectiveness of the solvent dilution method for HS-SPME analysis and proper solvents should be chosen according to their chemical properties and the matrix types. Besides solvent type, solvent amount used for matrix modification also played an important role in HS-SPME analysis. Considering the high volatility of methanol, the adsorption equilibrium achieved may be more sensitive to the variation of operation conditions than the undiluted original sample and may possibly result in poor repeatability. With the aim of investigating the effects of solvent amount on repeatability, various volumes (0, 800, 1800, and 2800 μl) of methanol were added to oil samples for matrix modification [ Fig. 3 (c)]. It was found that as the volume of methanol increased, the uptake of octanoic acid esters decreased. There were two possible reasons: first, as methanol was added into the oil sample, the increased total volume led to decreased original analyte concentrations and consequently reduced headspace concentration; second, methanol can also act as a rinsing solution during the adsorption process to reduce the uptake of interested analytes. Despite this, the sensitivity of the method for the target ester compounds remained sufficient. Fig. 3 (d) displays that the extraction reproducibility indicated by RSD levels for the five octanoic acid esters was also affected, but to different extents depending on the chemical properties of these esters and the volume of methanol added into oil matrix. For instance, the adsorption repeatability of EO was affected to a greater degree than that of other octanoic acid esters, especially (i)AO. This indicates that the interaction between solvent and the analyte with similar properties is more significant than other volatile compounds, which may induce greater variance of the adsorption results. Another possible reason is that EO has a lower boiling point than other octanoic acid esters and this may lead to the unstable adsorption result ( Antalick et al., 2010 ). Hence, the volume ratio of solvent to sample should be well designed according to the properties of solvent, analyte and sample matrix to improve reproducibility. Since the lowest RSD level for the adsorption of most esters was achieved at 800 μl of methanol, as a compromise between method sensitivity and RSD value, 800 μl was selected as the volume of methanol which was added into 200 μl of oil sample for matrix modification in the further study. For the conventional solvent extraction method, several hundred millilitres of solvent are usually consumed. In this study, less than 1 ml of methanol was applied to minimise the matrix effect on obtaining reproducible results. The amount of solvent could even be further reduced according to different requirements. 3.3 Optimisation of HS-SPME parameters Higher temperatures increase the release of analytes from their matrix but decrease the adsorption of analytes by the fibre coating due to the reduced partition coefficients, resulting in higher headspace concentrations during SPME analysis ( Purcaro, Morrison, Moret, Conte, & Marriott, 2007; Zhang & Pawliszyn, 1995 ). To obtain proper headspace sensitivity at shortest time with best reproducibility after solvent dilution, the effects of adsorption temperatures (40, 50, 60, 70 °C) on the uptake of five octanoic acid esters by the fibre from methanol-modified oil matrix were studied. Fig. 4 (a) shows that as the temperature increased the adsorption efficiency of most target esters were increased until an equilibrium state was reached at 60 °C, except for (i)AO [ Fig. 4 (a)], which may due to the different concentrations of the analytes present in the oil sample. From Fig. 4 (b) it can be seen that in the range of 40–60 °C, an increment of temperature can positively affect the repeatability of adsorption, and this may be because it was easier to achieve an equilibrium state at higher temperatures. However, the RSD levels increased as the temperature was further increased to 70 °C which was higher than the boiling point of methanol (64.7 °C). The undesirable pressurisation of the vial may be one reason for the reduced repeatability. Hence, on the basis of extraction capacity and repeatability, 60 °C was selected as the optimum adsorption temperature. Fig. 4 (c) and (d) show the effects of sampling time on extraction efficiency and repeatability in the range of 20–50 min. In the presence of methanol, except EO, the FID peak areas of the other four octanoic acid esters demonstrated similar changing trend as the extraction time increased. The adsorption of EO was less affected by the temperature in the studied range compared with other target esters, which may be because of its relatively lower boiling point ( Antalick et al., 2010 ). The stable state of adsorption and the best repeatability were both achieved at 30 min [ Fig. 4 (c) and (d)]. Even though the equilibrium state was not achieved at 30 min but at 40 min for most target esters, in order to obtain higher extraction efficiency and better repeatability, 30 min was selected as the routine adsorption time as a compromise. The optimum extraction conditions were determined as follows: using methanol as dilution solvent, the total sample volume was 1.0 ml (20% oil and 80% methanol), extraction temperature was 60 °C, and extraction time was 30 min. To test the repeatability, 10 samples from the same batch were analysed under the optimised conditions of the developed method, and the RSD levels of FID peak areas were 5.6% for EO, 6.0% for PO, 5.5% for IBO, 4.2% for BO and 3.2% for (i)AO. It indicates an improved repeatability achieved by this HS-SPME-GC–MS/FID method. 3.4 Quantitative analysis 3.4.1 Calibration and method validation EO, IBO, BO and (i)AO were quantified in this work, because PO standard was not available. The calibration curves for the four octanoic acid esters were linear within the given range of concentrations and their correlation coefficients ( R 2 ) were higher than 0.99. Linear range, R 2 values, LOD, LOQ, and equations are given in Table 2 . The method validation results are given in Table 2 . Accuracy indicated by recovery rates in the 95.2–98.1% range for different esters was achieved. The reproducibility of the developed method was tested by determining the intraday and interday precisions at two concentrations of ester standards (see Materials and methods) with results for the higher concentration shown in Table 2 . At the higher concentrations, the intraday and interday precisions (CV) were ⩽6.2 and ⩽4.4 respectively ( Table 2 ); at the lower concentrations, the intraday and interday precisions (CV) were ⩽9.8 and ⩽13.2, respectively (data not shown). Various precision levels were observed for different compounds due to their distinct chemical properties. However, there were no significant statistical differences between the intraday and interday precisions at both the higher and lower concentrations according to t -test. 3.4.2 Real sample analysis Under the optimised HS-SPME conditions, transesterified coconut oil sample was analysed by GC–MS ( Fig. 1 ). Seventeen major fatty acid esters were detected and identified, including five octanoic acid esters, five decanoic acid esters, five dodecanoic acid esters and one tetradecanoic acid ester ( Fig. 1 ). Among these esters, methyl decanoate and methyl dodecanoate may be from coconut oil. Free octanoic acid was also produced, which suggested that hydrolysis of triglycerides in coconut oil occurred during the transesterification reaction ( Cheirsilp, 2008 ). With the developed method, the amount of octanoic acid esters produced during transesterification was determined. Two hundred microlitres of sample (190 μl of blank coconut oil and 10 μl of transesterified coconut oil) mixed with 800 μl of methanol containing 174 μg of ethyl nonanoate (IS) was analysed by HS-SPME-GC–MS/FID. Results show that 7.78 mg of EO, 14.90 mg of IBO, 0.56 mg of BO, and 43.27 mg of (i)AO were produced per gram of coconut oil through transesterification, indicating that transesterification of coconut oil by adding fusel alcohols through biocatalysis is an effective way to produce flavour esters, especially octanoic acid esters. 4 Conclusion In this study, coconut oil and fusel alcohols, which are both sustainable natural materials, were utilised to produce natural octanoic acid esters through Lipozyme TL IM catalysed transesterification reaction. With the aim to quantify the formed octanoic acid esters in the oil sample, methanol was used to dilute oil sample to minimise fibre overloading and matrix effect. In addition, HS-SPME parameters were also optimised to ensure high extraction efficiency and good repeatability. Under the optimised HS-SPME conditions, the HS-SPME-GC–MS/FID quantitative analysis method was developed and validated. High sensitivity, accuracy and precision were achieved by analysing a small amount of oil sample, which indicated that solvent dilution was an effective matrix modification method for HS-SPME analysis of oil sample with high concentration analytes. The developed method is simple and fast, and may be applied to detect and determine the amounts of volatile ester flavour compounds in complex oil-based matrices such as butter oil and other vegetable oils. References Antalick et al., 2010 G. Antalick M.-C. 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Pawliszyn Quantitative extraction using an internally cooled solid phase microextraction device Analytical Chemistry 67 1 1995 34 43",
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        "title": "Utjecaj prekurzora na hlapljive sastojke vina dobivenog fermentacijom soka papaje pomoću mješovite kulture kvasaca",
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        "title": "Biotransformation of durian pulp by mono- and mixed-cultures of Saccharomyces cerevisiae and Williopsis saturnus",
        "abstract": "",
        "keywords": [
            "biotransformation",
            "flavour"
        ],
        "authors": [
            {
                "name": "pinrou lee",
                "org": ""
            },
            {
                "name": "anthony saputra",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": ""
            }
        ],
        "venue": "Lwt - Food Science and Technology",
        "year": 2012
    },
    "AP6a4fUS": {
        "id": "AP6a4fUS",
        "title": "Impact of two Williopsis yeast strains on the volatile composition of mango wine",
        "abstract": "",
        "keywords": [
            "volatiles",
            "flavour",
            "fermentation"
        ],
        "authors": [
            {
                "name": "xiao li",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2012
    },
    "4URrZqIz": {
        "id": "4URrZqIz",
        "title": "Potential of lactic acid bacteria to modulate coffee volatiles and effect of glucose supplementation: fermentation of green coffee beans and impact of coffee roasting: Potential of lactic acid bacteria to modulate coffee volatiles and effect of glucose supplementation",
        "abstract": "Coffee flavor can be significantly influenced by microbial activities in spontaneous fermentation of coffee cherries. The potential of lactic acid bacteria for flavor modulation through controlled fermentation of green coffee beans has not been explored. RESULTS Fermentation by Lactobacillus rhamnosus HN001 with and without 1% w/w glucose supplementation led to modification of flavor-related constituents in green coffee beans, which translated into modulation of coffee volatiles upon roasting. The lactic acid bacteria consumed almost all glucose and fructose, leaving sucrose behind. Amino acids and malic, citric, and succinic acids were partially catabolized. Glucose supplementation enhanced lactic acid production but repressed acetic acid formation. After roasting at 235?°C for 9 min, 12?min, and 15?min, the levels of furfurals in glucose-supplemented-fermented coffee were 10.5-, 2.7-, and 1.1-fold higher than those in the controls (nonsupplemented-unfermented coffee); furthermore, the levels of pyrazines in the controls were 11.9-, 10.1-, and 6.5-fold higher than those in the treated coffee. Glucose-supplemented fermentation yielded roasted coffee with stronger caramelic and burnt characteristics but weaker nutty notes. In roasted non-supplemented-fermented coffee, volatile production was generally reduced, resulting in a milder overall aroma. CONCLUSION Lactic acid fermentation of green coffee beans is a new strategy for coffee flavor modulation, creating novel aroma characteristics. ? 2018 Society of Chemical Industry",
        "keywords": "",
        "authors": [
            {
                "name": "Chenhui Wang",
                "org": "Department of Chemistry, Food Science and Technology Programme; National University of Singapore; Singapore Singapore"
            },
            {
                "name": "Jingcan Sun",
                "org": "Mane SEA Pte Ltd; Singapore"
            },
            {
                "name": "Benjamin Lassabliere",
                "org": "Mane SEA Pte Ltd; Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Mane SEA Pte Ltd; Singapore"
            },
            {
                "name": "Feifei Zhao",
                "org": "Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd; Shanghai China"
            },
            {
                "name": "Fangju Zhao",
                "org": "Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd; Shanghai China"
            },
            {
                "name": "Ying Chen",
                "org": "Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd; Shanghai China"
            },
            {
                "name": "Shao-Quan Liu",
                "org": "Department of Chemistry, Food Science and Technology Programme; National University of Singapore; Singapore Singapore"
            }
        ],
        "venue": "Journal of the Science of Food and Agriculture",
        "year": 2018
    },
    "Hhkk5ZOk": {
        "id": "Hhkk5ZOk",
        "title": "Lipase-catalysed synthesis of natural aroma-active 2-phenylethyl esters in coconut cream",
        "abstract": "The aim of this research was to study the feasibility of biosynthesising natural aroma-active 2-phenylethyl esters in coconut cream via biocatalysis. Five commercial fungal lipases (Palatase 20 000L, Lipase AYS “Amano”, Lipase A “Amano” 12, Piccantase A and Piccantase AN) were screened for their ability to produce 2-phenylethyl hexanoate and 2-phenylethyl octanoate from coconut cream supplemented with natural 2-phenylethanol. Palatase 20 000L and Lipase AYS “Amano” showed the greatest potential for the synthesis of 2-phenylethyl esters. The biosynthetic reaction by the lipase Palatase 20 000L was further studied under different temperature, pH, enzyme and substrate concentrations, with maximum ester synthesis obtained at 9% v/v 2-phenylethanol and 2.15–8.60 mg enzyme protein/100 ml of reaction mixture. A temperature range of 30–53 °C and a pH range of 5.2–8.5 had little effect on the lipase Palatase activity, respectively. The ester-synthesising reaction appeared to proceed by both alcoholysis and esterification. Keywords 2-Phenylethyl esters Lipases Coconut cream Alcoholysis Esterification 1 Introduction The esters 2-phenylethanol hexanoate and 2-phenylethanol octanoate are naturally present in trace amounts in alcoholic beverages, such as rums and wines ( Pino, 2007; Zea, Moyano, Moreno, Cortes, & Medina, 2001 ). These fruity floral esters are widely used in flavour and fragrance applications, such as apple, banana, fermented green pineapple, rose, vegetable, cacao, cognac, floral, grape, rum and wine flavours ( The Good Scents Company, 2009 ). They are traditionally produced by chemical synthesis, as obtaining them via natural extraction is costly. Alternative methods of obtaining natural flavours to meet the growing consumer demand include de novo synthesis by microbial fermentations or by biocatalysis ( Vandamme & Soetaert, 2002 ). The production of natural flavour esters using microbes and enzymes has been well investigated, though the studies are focused mainly on the fruity character impact of ester compounds, such as 3-methylbutyl-acetate of banana flavour and other esters of branched alcohols ( Vandamme & Soetaert, 2002 ). Studies on lipase-catalysed reactions have also successfully produced terpenyl and short-chain fatty acid esters as flavour chemicals ( De, Chatterjee, & Bhattacharyya, 1999; Leblanc et al., 1998 ). However, little information is available on secondary flavour-impact compounds, such as 2-phenylethyl esters that have a smaller market volume but are nevertheless still important components of flavour applications. To the best of our knowledge, there is only one report on 2-phenylethyl ester production that demonstrates the feasibility of producing these esters by lactic acid bacteria ( Liu, Holland, & Crow, 2003a ). Lipases are versatile biocatalysts that not only serve the primary function of hydrolysis, but are also capable of catalysing the reverse reaction to produce esters under certain conditions ( Bornscheuer, 2002 ). Ester formation can take place through direct esterification of alcohol with acid, or through reactions of esters with alcohols (alcoholysis), acids (acidolysis) or other esters (interesterification) ( Gunstone, 1999 ). In particular, direct esterification and alcoholysis have been extensively studied for the production of customised triglycerides and flavour esters ( Macedo, Lozano, & Pastore, 2003 ). By selecting the alcohol moiety, esters of mixed fatty acids can be produced using triglyceride sources with fatty acid profiles suitable for the desired product composition ( De et al., 1999 ). Coconut cream is the high fat layer obtained by centrifuging coconut milk. It has a fat content of approximately 25% w/v, and a unique abundance of C8 fatty acid (octanoic acid), at 4.6–10.0% w/w on the basis of coconut oil ( Codex Alimentarius Commission, 2001 ). It is readily available and is a low-cost alternative to the more expensive dairy lipids, hence making it attractive as a substrate for natural ester production, especially esters of C8 fatty acid. The production of 2-phenylethanol and its ester 2-phenylethyl acetate by various yeasts has been relatively well studied ( Albertazzi, Cardillo, Servi, & Zucchi, 1994; Etschmann, Bluemke, Sell, & Schrader, 2002; Etschmann & Schrader, 2006; Etschmann, Sell, & Schrader, 2003, 2004, 2005; Huang, Lee, & Chou, 2000; Stark, Munch, Sonnleitner, Marison, & Stockar von, 2002; Wittmann, Hans, & Bluemke, 2002 ). However, the production of other aroma-active, yet commercially valuable esters of 2-phenylethanol, such as 2-phenylethyl esters of C3–C8 fatty acids, has received no or little research attention. The objective of this research was to investigate the lipase-catalysed production of 2-phenylethyl esters of fatty acids from coconut cream and 2-phenylethanol, with emphasis on 2-phenylethyl octanoate for the reasons mentioned above. The results of this research are the basis for future developments in the enhancement of the enzyme performance and the process economics of this biocatalytic process. 2 Materials and methods 2.1 Materials UHT coconut cream containing 25.4% fat (Kara brand, Fairtech Holding Pte Ltd., Singapore) was purchased from a local supermarket in Singapore. Natural 2-phenylethanol, 2-phenylethyl octanoate and octanoic acid were obtained from Firmenich Asia Pte Ltd. (Singapore). Trioctanoin (tricaprylin) was purchased from Sigma–Aldrich (St. Louis, MO, USA). Five commercial lipases were obtained as samples form the following sources: palatase 20 000L (PAL) from Novozymes (Bagsvaerd, Denmark), lipase AYS “Amano” (AYS) and lipase A “Amano” 12 (A12) from Amano Enzymes Inc. (Nagoya, Japan), piccantase A (PIC A) and piccantase AN (PIC AN) from DSM Food Specialties (Village-Neuf, France). According to the information supplied by the enzyme manufacturers, lipases PAL and PIC A (both in liquid form) were produced from Rhizomucor miehei , lipase AYS (in powder form) was produced from Candida rugosa , and lipase A12 (in powder form) and PIC AN (in liquid form) were produced from Aspergillus niger . These lipases were selected on the basis of a previous study which showed that fungal lipases (not mammalian lipases) were able to catalyse ester synthesis in an aqueous environment ( Liu, Holland, & Crow, 2003b ). 2.2 Experimental procedures The experimental conditions used below were based on the results of preliminary experiments, a previous study ( Liu et al., 2003b ), and the information from the enzyme manufacturer. All reactions were conducted aseptically. To screen lipases for ester-synthesising activities, the reaction (total 100 ml) was carried out in 250-ml capped bottles containing 99 ml of coconut cream, 1 ml of 2-phenylethanol and 0.5 mg lipase protein. The controls contained no lipase, and the blank had no lipase and no 2-phenylethanol. The reaction mixture was incubated at 30 °C in a shaking water bath (100 rpm) for 28 h. To study the effects of 2-phenylethanol concentration, lipase protein concentration, temperature and pH on the production of 2-phenylethyl octanoate, the reactions were performed in 250-ml capped bottles containing 80 or 90 ml of coconut cream, an appropriate amount of 2-phenylethanol, deionised water and an appropriate amount of lipase protein in a total volume of 100 ml. The specific conditions used were described in the legends of figures in Section 3 . The reaction mixtures were incubated in a shaking water bath (100 rpm) for 24 h. To investigate the mechanism of lipase-catalysed synthesis of 2-phenylethyl octanoate, transesterification (alcoholysis) and esterification assays were performed in 250-ml capped bottles. The reaction mixture (100 ml) consisted of 80 mM potassium phosphate (pH 7.0), 500 mM 2-phenylethanol, 30 mM trioctanoin (for the transesterification reaction) or 95 mM octanoic acid (for the esterification reaction), 0.5 mg lipase protein, and an appropriate amount of deionised water. Controls had no added lipase. The reaction mixtures were incubated at 30 °C in a shaking water bath (100 rpm) for up to 40 min. 2.3 Analysis The enzyme protein concentration was assayed using a protein assay kit from Bio-Rad Laboratories (CA, USA) with bovine serum albumin (BSA) (Sigma–Aldrich) as standard. The volatile organic compounds (VOCs), including 2-phenylethyl esters, 2-phenylethanol and fatty acids, were analysed using headspace solid-phase microextraction (SPME) and gas chromatography–mass spectrometry–flame ionisation detection (GC–MS–FID). The headspace SPME device used was an integrated automated system consisting of a Gerstel SPME Multi-Purpose Sampler MPS 2 autosampler, an automated incubator, a fibre conditioner and a 32-vial tray holder (Gerstel, Germany). The SPME fibre used was a Supelco (Bellefonte, PA, USA) Carboxen/PDMS fibre (85 μm film thickness). A new fibre was conditioned at 250 °C, as instructed by the manufacturer. The SPME extraction conditions used here were based on the results of preliminary experiments to optimise extraction temperature, sample volume and extraction time (data not shown). A 20-ml glass vial was filled with 8 ml of samples (pre-acidified to pH 2.5 with 1 M sulphuric acid) and was sealed with a silicone-lined septum and a crimp top. The glass vial was incubated at 90 °C for 15 min with agitation (250 rpm), followed by exposure of the SPME fibre to the headspace of the sample for 45 min and desorption in the GC injector port for 300 s. The whole SPME process was run automatically using the Gerstel SPME Multi-Purpose Sampler MPS 2 autosampler as described above. The GC–MS–FID system consisted of a 6890 gas chromatograph equipped with a 5975 mass selective detector (MSD) and a flame ionisation detector (FID) from Agilent Technologies (CA, USA). The GC was equipped with a 50 m × 0.25 mm i.d. fused silica capillary FFAP column (film thickness 0.25 μm) from Quadrex Corporation (CT, USA). The injector port temperature was 250 °C. The carrier gas was helium with an inlet flow rate of 1.2 ml/min. The oven temperature was programed as follows: 4 min at 140 °C, then 5 °C/min to 240 °C, 16 min at 240 °C. The MSD was operated in the electron ionisation mode at 70 eV and FID temperature was set at 250 °C. The volatile compounds were identified by comparison of the spectra with databases in the MS library using the Agilent ChemStation software. The reproducibility of the method was assessed by analysing 15 identical samples, and the error was generally less than 10%. The concentrations of volatile compounds were expressed as FID peak areas. The data presented were the mean values of duplicate analyses. 3 Results and discussion The objective of this research was to investigate the lipase-catalysed synthesis of 2-phenylethyl esters in coconut cream supplemented with 2-phenylethanol in an aqueous milieu. The C6, C8 and C10 fatty acid esters of 2-phenylethanol have industrial applications; however, for clarity and brevity, emphasis was placed on the C8 ester of 2-phenylethanol, as it is the major ester that is expected to be produced according to the fatty acid composition of coconut fat (see Section 1 ). As discussed earlier in Section 1 , lipases can catalyse simultaneously hydrolysis and ester synthesis. Therefore, data on both C8 ester and acid were presented where appropriate. 3.1 Screening lipase activity for the biosynthesis of 2-phenylethyl octanoate in coconut cream with added 2-phenylethanol The time-course of the production of 2-phenylethyl octanoate by five commercial lipases is shown in Fig. 1 . The blank control (coconut cream only) and the control containing added 2-phenylethanol, but no lipase, had no detectable 2-phenylethyl octanoate. The reaction approached completion within 6 h, with lipase AYS producing the most 2-phenylethyl octanoate, followed by lipases PAL, PIC A, PIC AN and A12. Under these reaction conditions, hydrolysis and ester biosynthesis occurred concomitantly (data on hydrolysis not shown). The percentage conversion of 2-phenylethanol for the five lipases also reflected that lipase AYS and PAL displayed the highest activity, 92.4% and 85.2% conversion respectively, compared to the other lipases (PIC A: 74.3%; PIC AN: 20.2%; A12: 5%). Lipase PAL was selected for further study due to its availability in the laboratory, as opposed to AYS. 3.2 Effects of physicochemical factors on the biosynthesis of 2-phenylethyl octanoate by a lipase PAL in coconut cream The goal of this experiment was to gain an insight into how certain physicochemical factors (2-phenylethanol concentration, lipase protein concentration, temperature and pH) would affect the biosynthesis of 2-phenylethyl octanoate in coconut cream. A preliminary experiment was conducted to evaluate the effects of alcohol inhibition over a range of 0.5–20% v/v of 2-phenylethanol concentrations. Fig. 2 showed clear inhibition of hydrolysis when the 2-phenylethanol concentration was increased from 0.1% to 5% v/v (0.13–1.32:1 alcohol-to-triglyceride molar ratio), as can be observed from a marked reduction in C8 acid production, and an accompanying increase in the 2-phenylethyl octanoate yield. This was consistent with numerous studies on lipase-catalysed ester synthesis reactions, which established that sufficient amounts of alcohol were necessary for optimal ester yields and inhibition of hydrolysis, especially in the presence of high water activity ( Antczak, Kubiak, Antczak, & Bielecki, 2009; Boutur, Dubreucq, & Galzy, 1995; Briand, Dubreucq, & Galzy, 1995; Liu, Holland, & Crow, 2004; Liu et al., 2003b ). At concentrations of 2-phenylethanol higher than 5% v/v, an inhibitory effect on the overall lipase activity was observed, imposing a limit on alcohol substrate concentrations below the levels required for the full theoretical conversion of the substrates. Fig. 3 a–d shows the effects of the four factors on the biosynthesis of 2-phenylethyl octanoate catalysed by lipase PAL in coconut cream. The effect of lipase protein concentration was examined using a range of lipase PAL concentrations (0.43–8.60 mg lipase protein in 100 ml reaction mixtures) and the results are shown in Fig. 3 a. As the lipase amount increased from 0.43 to 2.15 mg, the yield of 2-phenylethyl octanoate increased significantly ( Fig. 3 a). Further increases in the lipase amount resulted in no increase in the 2-phenylethyl octanoate yield but increased octanoic acid production (data not presented). The effect of 2-phenylethanol concentration was re-evaluated at concentrations of 4–10% v/v with a higher lipase concentration of 6.45 mg protein in 100 ml reaction mixture. The optimum ester production was obtained at 2-phenylethanol concentration of about 9–10% v/v ( Fig. 3 b). The effect of temperatures of 30–53 °C had no marked effects on the yield of 2-phenylethyl octanoate production, with a higher temperature of 60 °C leading to about 50% reduction in the yield of 2-phenylethyl octanoate production, presumably due to enzyme deactivation ( Fig. 3 c). This suggests that the lipase PAL has a broad temperature optimum. Similarly, the pH range of 5.2–8.5 showed little effect on 2-phenylethyl octanoate synthesis, suggesting that the lipase PAL has a broad pH optimum ( Fig. 3 d). This was consistent with the broad pH range described in the product specifications provided by the lipase manufacturer. Although pH was not maintained throughout the reaction, the initial pH differences may be sufficient, as ester production dominated over hydrolysis at the start of the experiment, where 2-phenylethanol concentrations were high. Our findings are supported by a report that the lipase palatase has broad temperature and pH optima in the transesterification of sunflower oil with methanol ( Oliveiro & Rosa, 2006 ). 3.3 2-Phenylethyl octanoate-biosynthesising pathways In the aqueous 80 mM phosphate buffer (pH 7.0) system, the lipase PAL catalysed the production of 2-phenylethyl octanoate via both the esterification and alcoholysis pathways ( Fig. 4 ). The reaction blanks showed no significant ester production, with the small peak areas being likely a result of the carry-over of analytes during GC analysis. The result was contrary to the expectation that catalysis would take place mainly as alcoholysis, due to the high water activity of the aqueous medium that would thermodynamically favour the hydrolytic reaction over the ester biosynthesis. It has also been previously demonstrated by Liu et al. (2003b) that the ethyl butyrate biosynthesis by the lipase PAL in a similar aqueous phosphate buffer system proceeded by alcoholysis (tributyrin and ethanol as substrates) with no observable esterification (butyric acid and ethanol as substrates). Due to lipases possessing the characteristic property of interfacial activation ( Marangoni, 2002 ), the occurrence of direct esterification is an indication of 2-phenylethanol and octanoic acid being more hydrophobic and accumulating favourably at the oil–water–lipase interface, in comparison to the less surface-active triglycerides and more hydrophilic fatty acids and alcohols, such as tributyrin, butyric acid and ethanol. Therefore, the difference in the findings between the present study and that of Liu et al. (2003b) is likely due to the different hydrophobic properties of the alcohols and fatty acids used in the esterification reactions. Butyric acid and ethanol are highly hydrophilic and do not accumulate favourably at the oil–water–lipase interface in an aqueous medium, precluding direct esterification. On the contrary, octanoic acid and 2-phenylethanol are much more hydrophobic and accumulate favourably at the oil–water–lipase interface in an aqueous milieu, allowing direct esterification to take place. Boutur et al. (1995) and Marangoni (2002) have discussed that the longer chain and more hydrophobic alcohols and fatty acids tend to accumulate at the oil–water–lipase interface, providing conducive conditions for direct esterification despite the high water activity. Indeed, even highly water-soluble alcohols, such as methanol and ethanol can be directly esterified with long-chain fatty acids of C16–C18 in an aqueous environment catalysed by lipases ( Boutur et al., 1995; Ishii et al., 1990; Lecointe, Dubreucq, & Galzy, 1996 ). In this particular experiment, the ester synthesis reaction was conducted in an aqueous buffer solution. Nonetheless, the findings may be applicable to coconut cream. Both the esterification and alcoholysis reactions are likely to take place in coconut cream because of the hydrophobic nature of the reaction mixture (fat, longer chain fatty acids and 2-phenylethanol). Further research is required to verify this. 4 Conclusion In this study, we attempted to ascertain the potential of the lipase-catalysed production of natural aroma-active 2-phenylethyl esters in an aqueous coconut cream spiked with 2-phenylethanol, and to obtain an understanding of the characteristics of this catalyst-substrate-medium combination. Coconut cream is a cheap raw material readily available in abundance and can be biotransformed into a floral fruity flavour ingredient using lipase biotechnology. This novel flavour ingredient can have applications not only in flavour and fragrance formulations (especially upon extraction and separation), but also directly in food products, such as cheese ( Liu et al., 2004; Noronha, Cronin, O’Riordan, & O’Sullivan, 2008; Roger, Degas, & Gripon, 1988 ). A more thorough characterisation study and a proper optimisation of the processing parameters would be required at a later stage to establish the optimal set of conditions for improved economic viability. References Albertazzi et al., 1994 E. Albertazzi R. Cardillo S. Servi G. Zucchi Biogeneration of 2-phenylethanol and 2-phenylethyl acetate important aroma components Biotechnology Letters 16 5 1994 491 496 Antczak et al., 2009 M.S. Antczak A. Kubiak T. Antczak S. Bielecki Enzymatic biodiesel synthesis – Key factors affecting efficiency of the process Renewable Energy 34 2009 1185 1194 Bornscheuer, 2002 U.T. Bornscheuer Microbial carboxyl esterases: Classification, properties and application in biocatalysis FEMS Microbiology Reviews 26 2002 73 81 Boutur et al., 1995 O. Boutur E. Dubreucq P. Galzy Factors influencing ester synthesis catalyzed in aqueous media by the lipase from Candida deforrnans (Zach) Langeron and Guerra Journal of Biotechnology 42 1995 23 33 Briand et al., 1995 D. Briand E. Dubreucq P. Galzy Functioning and regioselectivity of the lipase of Candida parapsilosis (Ashford) Langeron and Talice in aqueous medium: New interpretation of regioselectivity taking acyl migration into account European Journal of Biochemistry 228 1995 169 175 Codex Alimentarius Commission, 2001 Codex Alimentarius Commission (2001). Report of the 17th session of the codex committee on fats and oils (ALINORM 01/17, Appendix II). De et al., 1999 B.K. De T. Chatterjee D.K. Bhattacharyya Synthesis of geranyl and citronellyl esters of coconut oil fatty acids through alcoholysis by Rhizomucor miehei lipase catalysis Journal of the American Oil Chemists’ Society 76 12 1999 1501 1504 Etschmann et al., 2002 M.M.W. Etschmann W. Bluemke D. Sell J. Schrader Biotechnological production of 2-phenylethanol Applied Microbiology and Biotechnology 59 2002 1 8 Etschmann and Schrader, 2006 M.M.W. Etschmann J. Schrader An aqueous-organic two-phase bioprocess for efficient production of the natural aroma chemicals 2-phenylethanol and 2-phenylethyl acetate with yeast Applied Microbiology and Biotechnology 71 2006 440 443 Etschmann et al., 2003 M.M.W. Etschmann D. Sell J. Schrader Screening of yeasts for the production of the aroma compound 2-phenylethanol in a mollases-based medium Biotechnology Letters 25 2003 531 536 Etschmann et al., 2004 M.M.W. Etschmann D. Sell J. Schrader Medium optimization for the production of the aroma compound 2-phenylethanol using a genetic algorithm Journal of Molecular Catalysis B: Enzymatic 29 2004 187 193 Etschmann et al., 2005 M.M.W. Etschmann D. Sell J. Schrader Production of 2-phenylethanol and 2-phenylethyl acetate from l -phenylalanine by coupling whole-cell biocatalysis with organophilic pervaporation Biotechnology and Bioengineering 92 2005 624 634 Gunstone, 1999 F.D. Gunstone Review – Enzymes as biocatalysts in the modification of natural lipids Journal of the Science of Food and Agriculture 79 1999 1535 1549 Huang et al., 2000 C.J.R. Huang S.L. Lee C.C. Chou Production and molar yield of 2-phenylethanol by Pichia fermentans L-5 as affected by some medium components Journal of Bioscience and Bioengineering 90 2 2000 142 147 Ishii et al., 1990 T. Ishii T. Mori J. Chen Y. Itoh S. Shimura K. Kirimura Ester synthesis by a crude lipase of Rhizopus oligosporus in an aqueous system Journal of Fermentation and Bioengineering 70 3 1990 188 189 Leblanc et al., 1998 D. Leblanc A. Morin X.M. Zhang J.-G. Bisaillon M. Paquet H. Dubeau Short chain fatty acid esters synthesis by commercial lipases in low-water systems and by resting microbial cells in aqueous medium Biotechnology Letters 20 12 1998 1127 1131 Lecointe et al., 1996 C. Lecointe E. Dubreucq P. Galzy Ester synthesis in aqueous media in the presence of various lipases Biotechnology Letters 18 8 1996 869 874 Liu et al., 2003a S.Q. Liu R. Holland V. Crow Ester synthesis in an aqueous environment by Streptococcus thermophilus and other dairy lactic acid bacteria Applied Microbiology and Biotechnology 63 2003 81 88 Liu et al., 2003b S.Q. Liu R. Holland V. Crow Synthesis of ethyl butanoate by a commercial lipase in aqueous media under conditions relevant to cheese ripening Journal of Dairy Research 70 2003 359 363 Liu et al., 2004 S.Q. Liu R. Holland V. Crow Esters and their biosynthesis in fermented dairy products: A review International Dairy Journal 14 2004 923 945 Macedo et al., 2003 G.A. Macedo M.M.S. Lozano G.M. Pastore Enzymatic synthesis of short chain citronellyl esters by a new lipase from Rhizopus sp . Electronic Journal of Biotechnology 6 1 2003 72 75 Marangoni, 2002 A.G. Marangoni Lipases: structure, function, and properties M.K. Tsung H.W. Gardner Lipid biotechnology 2002 Marcel Dekker, Inc. New York 357 386 Noronha et al., 2008 N. Noronha D.A. Cronin E.D. O’Riordan M. O’Sullivan Flavouring of imitation cheese with enzyme-modified cheeses (EMCs): Sensory impact and measurement of aroma active short chain fatty acids (SCFAs) Food Chemistry 106 2008 905 913 Oliveiro and Rosa, 2006 A.C. Oliveiro M.F. Rosa Enzymatic transesterification of sunflower oil in an aqueous-oil biphasic system Journal of the American Oil Chemists’ Society (JAOCS) 83 2006 21 25 Pino, 2007 J.A. Pino Characterization of rum using solid-phase microextraction with gas chromatography–mass spectrometry Food Chemistry 104 2007 421 428 Roger et al., 1988 S. Roger C. Degas J.C. Gripon Production of phenylethyl alcohol and its esters during ripening of traditional Camembert Food Chemistry 28 1988 129 140 Stark et al., 2002 D. Stark T. Munch B. Sonnleitner I.W. Marison U. Stockar von Extractive bioconversion of 2-phenylethanol from l -phenylalanine by Saccharomyces cerevisiae Biotechnology Progress 18 2002 514 523 The Good Scents Company, 2009 The Good Scents Company (2009). Flavor and fragrance information catalog. < http://www.thegoodscentscompany.com/allprod.html > Accessed 09.03.09. Vandamme and Soetaert, 2002 E.J. Vandamme W. Soetaert Bioflavours and fragrances via fungi and their enzymes Journal of Chemical Technology and Biotechnology 77 2002 1323 1332 Wittmann et al., 2002 C. Wittmann M. Hans W. Bluemke Metabolic physiology of aroma-producing Kluyveromyces marxianus Yeast 19 2002 1351 1363 Zea et al., 2001 L. Zea L. Moyano J. Moreno B. Cortes M. Medina Discrimination of the aroma fraction of Sherry wines obtained by oxidative and biological ageing Food Chemistry 75 2001 79 84",
        "keywords": [
            "enzyme"
        ],
        "authors": [
            {
                "name": "Hui Shan Grace Tan",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Firmenich Asia Pte Ltd., Tuas, Singapore"
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte Ltd., Tuas, Singapore"
            },
            {
                "name": "Shao Quan Liu",
                "org": ""
            }
        ],
        "venue": "Food Chemistry",
        "year": 2011
    },
    "e6Ucd8Xw": {
        "id": "e6Ucd8Xw",
        "title": "Cider fermentation with three Williopsis saturnus yeast strains and volatile changes",
        "abstract": " Williopsis saturnus var. subsufficiens NCYC 2728, W. saturnus var. saturnus NCYC 22 and W. saturnus var. mrakii NCYC 500 were used to carry out cider fermentation to assess their impact on the volatile composition of cider. The changes of yeast cell population, °Brix and pH were similar among the three yeasts. Strain NCYC 500 grew best, with the highest cell population of 1.14 × 108 CFU ml−1, followed by strains NCYC 2728 and NCYC 22 (8 × 107 CFU ml−1 and 3.19 × 107 CFU ml−1 respectively). Esters were the most abundant volatiles produced, followed by alcohols. Among the esters, ethyl acetate, 2-phenylethyl acetate, isoamyl acetate, cis-3-hexenyl acetate and hexyl acetate were the major volatiles. The major alcohols were ethanol, isoamyl alcohol, 2-phenylethyl alcohol and isobutyl alcohol. The three Williopsis yeasts transformed volatile compounds during cider fermentation with significant variations in terms of volatile production and degradation. This study implied that fermentation with Williopsis yeasts could result in cider with a more complex yet fruity aroma.",
        "keywords": [
            "Cider",
            " Fermentation",
            " Williopsis",
            " Volatiles",
            " Flavor",
            " Yeasts"
        ],
        "authors": [
            {
                "name": "ma thandar aung",
                "org": "national university of singapore"
            },
            {
                "name": "pinrou lee",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": "agilent technologies"
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "Annals of Microbiology",
        "year": 2014
    },
    "m41TM7Iv": {
        "id": "m41TM7Iv",
        "title": "Modulation of the volatile and non-volatile profiles of coffee fermented with Yarrowia lipolytica: I. Green coffee",
        "abstract": "Abstract   The fermentation of green coffee beans by  Yarrowia lipolytica  led to significant changes in the volatile and non-volatile profiles of green coffees (Part I). Therefore, the objective of this continuation study was to evaluate the effects of fermentation after roasting by characterizing the volatile profiles of coffees at three different roast levels and non-volatile profiles of coffee where the effects of fermentation on volatiles were most prominent (light roast).  Y. lipolytica  fermentation led to significant changes in the volatile profiles of roasted coffees which arose from both the modification of aroma precursors and the retention of volatile profile changes observed in green fermented coffees. The levels of 4-vinylguaiacol and 4-vinylphenol were 1.2-fold and 1.6-fold higher in light roasted fermented coffees respectively and could be explained by the higher levels detected in green fermented coffees before roasting. The levels of γ-butyrolactone were 5 times higher in light roasted fermented coffees than unfermented coffees. The increase in sulfur compounds levels and decrease in ketones levels were attributed to changes in the concentrations of aroma precursors like sugars and amino acids. Thus, this study highlighted the potential of utilizing yeast fermentation of green coffee beans for coffee aroma modulation.",
        "keywords": "",
        "authors": [
            {
                "name": "Liang Wei Lee",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, 117542, Singapore"
            },
            {
                "name": "Geng Yu Tay",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, 117542, Singapore"
            },
            {
                "name": "Mun Wai Cheong",
                "org": "Kerry Ingredients Asia Pacific, 8 Biomedical Grove, #02-01/04 Neuros, 138665, Singapore"
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte Ltd., 10 Tuas West Road, 638377, Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Silesia Flavours South East Asia Pte Ltd., 41 Science Park Road, The Gemini, Science Park II, 117610, Singapore"
            },
            {
                "name": "Shao-Quan Liu",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, 117542, Singapore"
            }
        ],
        "venue": "Lwt - Food Science and Technology",
        "year": 2017
    },
    "bC4WNeo3": {
        "id": "bC4WNeo3",
        "title": "Characterisation of volatile and non-volatile compounds in pomelo by gas chromatography-olfactometry, gas chromatography and liquid chromatography-quadrupole time-of-flight mass spectrometry",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Min Vivian Goh",
                "org": "Food Science and Technology Programme Department of Chemistry National University of Singapore Singapore"
            },
            {
                "name": "Aileen Pua",
                "org": "Food Science and Technology Programme; Department of Chemistry; National University of Singapore; Singapore"
            },
            {
                "name": "Shao Quan Liu",
                "org": "Food Science and Technology Programme Department of Chemistry National University of Singapore Singapore"
            },
            {
                "name": "Benjamin Lassabliere",
                "org": "Mane SEA PTE LTD, Singapore"
            },
            {
                "name": "Kwong-Chee Leong",
                "org": "Mane SEA PTE LTD, Singapore"
            },
            {
                "name": "Jingcan Sun",
                "org": "Mane SEA PTE LTD, Singapore"
            },
            {
                "name": "Hazel Lau",
                "org": "Mane SEA PTE LTD, Singapore"
            },
            {
                "name": "Lay Peng Tan",
                "org": "Agilent Technologies Singapore (Sales) Pte Ltd, Singapore"
            },
            {
                "name": "Wen Lin Zhang",
                "org": "Agilent Technologies Singapore (Sales) Pte Ltd, Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Mane SEA PTE LTD, Singapore"
            }
        ],
        "venue": "Journal of Essential Oil Research",
        "year": 2019
    },
    "BHuDQ9fg": {
        "id": "BHuDQ9fg",
        "title": "Modulation of coffee aroma via the fermentation of green coffee beans with Rhizopus oligosporus: I. Green coffee.",
        "abstract": "Modulation of coffee aroma via the biotransformation/fermentation of different coffee matrices during post-harvest remains sparingly explored despite some studies showing their positive impacts on coffee aroma. Therefore, this is an unprecedented study aimed at modulating coffee aroma via the fermentation of green coffee beans with a food-grade fungus Rhizopus oligosporus. The objective of part I of this two-part study was to characterize the volatile and non-volatile profiles of green coffee beans after fermentation. Proteolysis during fermentation resulted in 1.5-fold increase in the concentrations of proline and aspartic acid which exhibited high Maillard reactivity. Extensive degradation of ferulic and caffeic acids led to 2-fold increase in the total concentrations of volatile phenolic derivatives. 36% of the total volatiles detected in fermented green coffee beans were generated during fermentation. Hence, the work presented demonstrated that R. oligosporus fermentation of green coffee beans could induce modification of the aroma precursors of green coffees. ",
        "keywords": [
            "Aroma precursors",
            "Extracellular enzymes",
            "Fermentation",
            "Green coffee beans",
            "Rhizopus oligosporus",
            "Volatile profile"
        ],
        "authors": [
            {
                "name": "Liang Wei Lee",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore."
            },
            {
                "name": "Mun Wai Cheong",
                "org": "Kerry Ingredients Asia Pacific, 8 Biomedical Grove, #02-01/04 Neuros, Singapore 138665, Singapore."
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte Ltd., 10 Tuas West Road, Singapore 638377, Singapore."
            },
            {
                "name": "Bin Yu",
                "org": "Silesia Flavours South East Asia Pte Ltd., 41 Science Park Road, The Gemini, Science Park II, Singapore 117610, Singapore."
            },
            {
                "name": "Shao Quan Liu",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore; National University of Singapore (Suzhou) Research Institute, No. 377 Linquan Street, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China. Electronic address: chmLsq@nus.edu.sg."
            }
        ],
        "venue": "Food chemistry",
        "year": 2016
    },
    "YnPO98Tn": {
        "id": "YnPO98Tn",
        "title": "Determination of Flavor Esters in Enzymatically Transformed Coconut Oil",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jingcan sun",
                "org": "national university of singapore"
            },
            {
                "name": "jin hua chin",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "Journal of Food Biochemistry",
        "year": 2013
    },
    "bvqTcrim": {
        "id": "bvqTcrim",
        "title": "Effect of fusel oil addition on volatile compounds in papaya wine fermented with Williopsis saturnus var. mrakii NCYC 2251",
        "abstract": "The impact of fusel oil addition on volatile compounds formation in papaya wine fermented with yeast Williopsis saturnus var. mrakii NCYC2251 was studied with a view to enhancing papaya wine aroma production. Time-course papaya juice fermentations were carried out using W. saturnus var. mrakii NCYC2251 with fusel oil added (0, 0.1 and 0.5% v/v). Fermentation characteristics in terms of yeast growth, Brix and pH changes were similar for all fermentations except for those added with 0.5% (v/v) fusel oil. The addition of 0.5% (v/v) fusel oil inhibited yeast growth. A wide range of volatile compounds were produced during fermentation including acids, alcohols, esters and aldehydes with esters being the most abundant volatile compounds produced. The addition of 0.1% (v/v) fusel oil reduced the production of undesirable volatiles such as ethyl acetate and acetic acid, while increasing the desirable volatiles production such as ethanol and acetate esters. This study suggests that papaya juice fermentation with W. saturnus var mrakii NCYC 2251 together with a low concentration of added fusel oil can be another means of modulating papaya wine aroma compound formation.",
        "keywords": [
            "fusel oil",
            "fermentation",
            "volatile compounds",
            "papaya wine",
            "williopsis",
            "yeast"
        ],
        "authors": [
            {
                "name": "Pin-Rou Lee",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, 4 Science Drive 4, Singapore 117543, Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Firmenich Asia Pte Ltd, Tuas, Singapore, Singapore"
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte Ltd, Tuas, Singapore, Singapore"
            },
            {
                "name": "Shao-Quan Liu",
                "org": ""
            }
        ],
        "venue": "Food Research International",
        "year": 2011
    },
    "92M4cnCy": {
        "id": "92M4cnCy",
        "title": "Lipase-catalysed transesterification of coconut oil with fusel alcohols in a solvent-free system",
        "abstract": "",
        "keywords": [
            "fusel alcohols"
        ],
        "authors": [
            {
                "name": "jingcan sun",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": ""
            }
        ],
        "venue": "Food Chemistry",
        "year": 2012
    },
    "MWwbejF9": {
        "id": "MWwbejF9",
        "title": "Potential of lactic acid bacteria to modulate coffee volatiles and effect of glucose supplementation: Fermentation of green coffee beans and impact of coffee roasting.",
        "abstract": "Lactic acid fermentation of green coffee beans is a new strategy for coffee flavor modulation, creating novel aroma characteristics. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "Coffee",
            "Lactobacillus rhamnosus",
            "coffee flavor",
            "lactic acid fermentation",
            "volatile precursors"
        ],
        "authors": [
            {
                "name": "Chenhui Wang",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, Science Drive 3, Singapore, 117543, Singapore."
            },
            {
                "name": "Jingcan Sun",
                "org": "Mane SEA PTE LTD, Biopolis Drive 3, 138623, Singapore."
            },
            {
                "name": "Benjamin Lassabliere",
                "org": "Mane SEA PTE LTD, Biopolis Drive 3, 138623, Singapore."
            },
            {
                "name": "Bin Yu",
                "org": "Mane SEA PTE LTD, Biopolis Drive 3, 138623, Singapore."
            },
            {
                "name": "Feifei Zhao",
                "org": "Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd, No. 118 Gaodong Road, Pudong New District, Shanghai, 200137, China."
            },
            {
                "name": "Fangju Zhao",
                "org": "Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd, No. 118 Gaodong Road, Pudong New District, Shanghai, 200137, China."
            },
            {
                "name": "Ying Chen",
                "org": "Wilmar (Shanghai) Biotechnology Research & Development Center Co., Ltd, No. 118 Gaodong Road, Pudong New District, Shanghai, 200137, China."
            },
            {
                "name": "Shao Quan Liu",
                "org": "National University of Singapore (Suzhou) Research Institute, No. 377 Linquan Street, Suzhou Industrial Park, Suzhou, Jiangsu, 215123, China."
            }
        ],
        "venue": "Journal of the science of food and agriculture",
        "year": 2018
    },
    "pwp5f2TF": {
        "id": "pwp5f2TF",
        "title": "Kinetics of volatile organic compounds during papaya juice fermentation by three commercial wine yeasts",
        "abstract": "",
        "keywords": [
            "optical density",
            "kinetics",
            "design methodology",
            "wine yeast",
            "gas chromatography mass spectrometry",
            "fatty acid",
            "nitrogen",
            "food technology",
            "fermentation",
            "flame ionization detector"
        ],
        "authors": [
            {
                "name": "pinrou lee",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "Nutrition & Food Science",
        "year": 2013
    },
    "0MSYWuR0": {
        "id": "0MSYWuR0",
        "title": "FORMATION OF AROMA COMPOUNDS DURING LONGAN JUICE FERMENTATION BY WILLIOPSIS SATURNUS VAR. SATURNUS WITH THE ADDITION OF SELECTED AMINO ACIDS: LONGAN WINE AROMA FERMENTED WITH WILLIOPSIS SATURNUS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shaoquan liu",
                "org": ""
            },
            {
                "name": "phillip curran",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "thithanhtam trinh",
                "org": ""
            }
        ],
        "venue": "Journal of Food Processing and Preservation",
        "year": 2011
    },
    "zfgmWLQf": {
        "id": "zfgmWLQf",
        "title": "Improved detection of key odourants in Arabica coffee using gas chromatography-olfactometry in combination with low energy electron ionisation gas chromatography-quadrupole time-of-flight mass spectrometry.",
        "abstract": "Four Arabica coffees (Brazil, Colombia, Ethiopia, and Guatemala) yield highly variant odours, attesting to the complexities of coffee aroma that command advanced analytical tools. In this study, their volatiles were extracted using solvent-assisted flavour evaporation (SAFE) and headspace solid-phase microextraction (HS-SPME). Due to matrix complexity, some trace odourants were detected in SAFE extracts by aroma extract dilution analysis (AEDA) but remained difficult to quantify by gas chromatography-mass spectrometry (GC-MS). This prompted the application of low energy electron ionisation (EI) coupled with GC-quadrupole time-of-flight (GC-QTOF). Optimal low EI GC-QTOF parameters (EI energy: 15 eV, acquisition rate: 3 Hz) were applied to achieve improved molecular ion signal intensity and reproducibility (relative standard deviation < 10%) across five compounds, which resulted in good linearity (R ≥ 0.999) and lowered detection levels (e.g. 0.025 ± 0.005 ng/mL for 4-hydroxy-5-methyl-3(2H)-furanone). Therefore, this method potentially improves the measurement of trace odourants in complex matrices by increasing specificity and sensitivity.",
        "keywords": [
            "AEDA",
            "Coffee",
            "GC-QTOF",
            "Low energy EI",
            "Volatiles"
        ],
        "authors": [
            {
                "name": "Aileen Pua",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore."
            },
            {
                "name": "Hazel Lau",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore."
            },
            {
                "name": "Shao Quan Liu",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore. Electronic address: chmlsq@nus.edu.sg."
            },
            {
                "name": "Lay Peng Tan",
                "org": "Agilent Technologies Singapore (Sales) Pte Ltd, 1 Yishun Avenue 7, Singapore 768923, Singapore."
            },
            {
                "name": "Rui Min Vivian Goh",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore."
            },
            {
                "name": "Benjamin Lassabliere",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Kwong-Chee Leong",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Jingcan Sun",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Maurin Cornuz",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Bin Yu",
                "org": "Mane SEA PTE LTD, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore. Electronic address: gsgpbiy@gmail.com."
            }
        ],
        "venue": "Food chemistry",
        "year": 2019
    },
    "llHDlDRL": {
        "id": "llHDlDRL",
        "title": "Growth and fermentation kinetics of a mixed culture of Saccharomyces cerevisiae var. bayanus and Williopsis saturnus var. saturnus at different ratios in longan juice (Dimocarpus longan Lour.): Longan wine by mixed yeasts",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shaoquan liu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "wei ya woon",
                "org": ""
            },
            {
                "name": "thithanhtam trinh",
                "org": ""
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2010
    },
    "IgDfIjE0": {
        "id": "IgDfIjE0",
        "title": "FORMATION OF AROMA COMPOUNDS DURING LONGAN JUICE FERMENTATION BY WILLIOPSIS SATURNUS VAR. SATURNUS WITH THE ADDITION OF SELECTED AMINO ACIDS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "thithanhtam trinh",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "phillip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "Journal of Food Processing and Preservation",
        "year": 2012
    },
    "lxkSIjM8": {
        "id": "lxkSIjM8",
        "title": "Evolution of volatile compounds in papaya wine fermented with three Williopsis saturnus yeasts: Papaya wine fermented by W. saturnus yeasts",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shaoquan liu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "pinrou lee",
                "org": ""
            },
            {
                "name": "yuenling ong",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2010
    },
    "RiqRL5SZ": {
        "id": "RiqRL5SZ",
        "title": "Effect of L-isoleucine and L-phenylalanine addition on aroma compound formation during longan juice fermentation by a co-culture of Saccharomyces cerevisiae and Williopsis saturnus.",
        "abstract": "",
        "keywords": [
            "fermentation",
            "aromatic compounds"
        ],
        "authors": [
            {
                "name": "t t t trinh",
                "org": ""
            },
            {
                "name": "wei ya woon",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "p j curran",
                "org": ""
            },
            {
                "name": "shao quan liu",
                "org": ""
            }
        ],
        "venue": "South African Journal of Enology and Viticulture",
        "year": 2010
    },
    "WDqqVXEE": {
        "id": "WDqqVXEE",
        "title": "Bioproduction of natural isoamyl esters from coconut cream as catalysed by lipases.",
        "abstract": "",
        "keywords": [
            "biosynthesis",
            "enzymes",
            "enzyme activity",
            "alcohols",
            "ph",
            "flavour"
        ],
        "authors": [
            {
                "name": "s q liu",
                "org": ""
            },
            {
                "name": "huey yie lee",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "jingcan sun",
                "org": ""
            }
        ],
        "venue": "Journal of Field Robotics",
        "year": 2013
    },
    "t8AJpWqJ": {
        "id": "t8AJpWqJ",
        "title": "Sugars, organic acids, and phenolic acids of exotic seasonable tropical fruits",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pinrou lee",
                "org": ""
            },
            {
                "name": "rouming tan",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": ""
            }
        ],
        "venue": "Nutrition & Food Science",
        "year": 2013
    },
    "98V3U712": {
        "id": "98V3U712",
        "title": "Original article: Evolution of volatile compounds in papaya wine fermented with three Williopsis saturnus yeasts: Papaya wine fermented by W. saturnus yeasts",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Pin-Rou Lee",
                "org": ""
            },
            {
                "name": "Yuen-Ling Ong",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Philip Curran",
                "org": ""
            },
            {
                "name": "Shao-Quan Liu",
                "org": ""
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2010
    },
    "Hj8pPaVG": {
        "id": "Hj8pPaVG",
        "title": "Effects of Pure and Mixed-Cultures of Saccharomyces cerevisiae and Williopsis saturnus on the Volatile Profiles of Grape Wine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pinrou lee",
                "org": ""
            },
            {
                "name": "anthony saputra",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": ""
            }
        ],
        "venue": "Food Biotechnology",
        "year": 2012
    },
    "e3BEOTof": {
        "id": "e3BEOTof",
        "title": "Characterization of Volatile Compounds and Aroma Profiles of Malaysian Pomelo (Citrus grandis (L.) Osbeck) Blossom and Peel",
        "abstract": "",
        "keywords": [
            "sensory evaluation",
            "principal component analysis",
            "chemical composition"
        ],
        "authors": [
            {
                "name": "munwai cheong",
                "org": "national university of singapore"
            },
            {
                "name": "xiuqing loke",
                "org": "national university of singapore"
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            },
            {
                "name": "k pramudya",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": "national university of singapore"
            }
        ],
        "venue": "Journal of Essential Oil Research",
        "year": 2011
    },
    "GtR3Fyd6": {
        "id": "GtR3Fyd6",
        "title": "Characterising the release of flavour compounds from chewing gum through HS-SPME analysis and mathematical modelling",
        "abstract": "The headspace solid-phase microextraction (HS-SPME) technique combined with GC–MS was evaluated to study 33 selected flavour compounds released from chewing gum. The operating conditions of SPME were optimised, including different fibres (PDMS, DVB/CAR/PDMS, PA and PDMS/DVB), sample size, extraction time and temperature. The results indicated that while HS-SPME was a rapid and valuable technique, poor reproducibility occurred under all conditions. It was found that this deficiency could be alleviated by utilising mathematical modelling techniques, an approach which had not been previously used in the analysis of flavour compounds in chewing gum by HS-SPME. Compared to the instrumental analysis data themselves, the models provided more insights to the release behaviour of flavour compounds from chewing gum and the more reproducible kinetic rate constants might be used for comparing the release of different compounds or the same compound under different conditions.",
        "keywords": [
            "gc–ms",
            "hs-spme",
            "flavour release",
            "flavour compounds",
            "mathematical modelling",
            "chewing gum",
            "gc ms",
            "rate constant",
            "flavour",
            "operant conditioning",
            "sample size",
            "kinetics",
            "mathematical models",
            "extraction",
            "analytical methods"
        ],
        "authors": [
            {
                "name": "Sook Wai Wong",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Firmenich Asia Pte. Ltd., 10 Tuas West Road, Singapore 638377, Singapore"
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte. Ltd., 10 Tuas West Road, Singapore 638377, Singapore"
            },
            {
                "name": "Weibiao Zhou",
                "org": ""
            }
        ],
        "venue": "Food Chemistry",
        "year": 2009
    },
    "ovvGt3RN": {
        "id": "ovvGt3RN",
        "title": "Yeast ratio is a critical factor for sequential fermentation of papaya wine by Williopsis saturnus and Saccharomyces cerevisiae : Papaya wine fermentation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shaoquan liu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "stephanie hui chern kho",
                "org": ""
            },
            {
                "name": "pinrou lee",
                "org": ""
            }
        ],
        "venue": "Microbial Biotechnology",
        "year": 2012
    },
    "Ocdv98s8": {
        "id": "Ocdv98s8",
        "title": "Modulation of coffee aroma via the fermentation of green coffee beans with Rhizopus oligosporus: II. Effects of different roast levels.",
        "abstract": "This study aims to evaluate how changes of the volatile and non-volatile profiles of green coffees induced by Rhizopus oligosporus fermentation of green coffee beans (Part I) translated to changes in the volatile and aroma profiles of light, medium and dark roasted coffees and non-volatile profile of roasted coffee where fermentation effects were most distinctive (light roast). R. oligosporus fermentation resulted in 1.7-, 1.5- and 1.3-fold increases in pyrazine, 2-methylpyrazine and 2-ethylpyrazine levels in coffees of all roast degrees, respectively. This corresponded with the greater extent of amino acids degradation in light roasted fermented coffee. Ethyl palmitate was detected exclusively in medium and dark roasted fermented coffees. The sweet attribute of light and dark roasted coffees were increased following fermentation along with other aroma profile changes that were roast degree specific. This work aims to develop a direct but novel methodology for coffee aroma modulation through green coffee beans fermentation. ",
        "keywords": [
            "Biotransformation",
            "Coffee aroma",
            "Fermentation",
            "Rhizopus oligosporus",
            "Roasted coffee",
            "Volatile profile"
        ],
        "authors": [
            {
                "name": "Liang Wei Lee",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore."
            },
            {
                "name": "Mun Wai Cheong",
                "org": "Kerry Ingredients Asia Pacific, 8 Biomedical Grove, #02-01/04 Neuros, Singapore 138665, Singapore."
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte Ltd., 10 Tuas West Road, Singapore 638377, Singapore."
            },
            {
                "name": "Bin Yu",
                "org": "Silesia Flavours South East Asia Pte Ltd., 41 Science Park Road, The Gemini, Science Park II, Singapore 117610, Singapore."
            },
            {
                "name": "Shao Quan Liu",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore; National University of Singapore (Suzhou) Research Institute, No. 377 Linquan Street, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China. Electronic address: chmLsq@nus.edu.sg."
            }
        ],
        "venue": "Food chemistry",
        "year": 2016
    },
    "PsZVrr0L": {
        "id": "PsZVrr0L",
        "title": "Yeast and volatile evolution in cider co-fermentation with Saccharomyces cerevisiae and Williopsis saturnus",
        "abstract": "This research was conducted to evaluate the impact of co-fermentation with Saccharomyces cerevisiae and Williopsis saturnus var. mrakii on the volatile profile of cider. Cider co-fermentation was carried out by co-inoculating S. cerevisiae and W. saturnus var. mrakii at a ratio of 1:100. Changes in yeast cell population, total soluble solid content (degrees Brix [°Bx]), and pH were monitored. Volatiles were analysed using headspace solid-phase microextraction/gas chromatography–mass spectrometry/flame ionization detector (HS-SPME/GC-MS-FID). A diverse group of volatiles, including fatty acids, alcohols, aldehydes, esters and ketones, were identified, among which alcohols and esters were the predominant compounds. Although most of these compounds showed similar dynamics of change, the final concentrations of some volatiles differed significantly between single-culture and co-culture fermentations. Volatiles that were indigenous to apple juice decreased during fermentation, while production of isoamyl acetate, 2-phenylethyl acetate, ethyl acetate, ethyl decanoate, ethyl dodecanoate and ethyl octanoate varied significantly among the monocultures and co-culture. Co-fermentation by S. cerevisiae and W. saturnus resulted in a more complex volatile profile, which could impact on the aromatic characteristics of cider, thus representing a novel way to modulate flavour.",
        "keywords": [
            "Cider",
            " Co-fermentation",
            " Volatiles",
            " Flavour",
            " Yeasts"
        ],
        "authors": [
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            },
            {
                "name": "ma thandar aung",
                "org": "national university of singapore"
            },
            {
                "name": "pinrou lee",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": "Silesia Pte. Ltd.,Science Park II,Singapore"
            }
        ],
        "venue": "Annals of Microbiology",
        "year": 2015
    },
    "1rst2w6u": {
        "id": "1rst2w6u",
        "title": "Lipase-catalysed ester synthesis in solvent-free oil system: is it esterification or transesterification?",
        "abstract": "Ester synthesis was carried out in a solvent-free system of lipase, coconut oil and ethanol or fusel alcohols to ascertain the reaction mechanism. During ester formation, octanoic and decanoic acids increased initially and then decreased gradually, indicating that ester production was a two-step reaction consisting of hydrolysis and esterification, rather than alcoholysis. With ethanol as the alcohol substrate, added butyric acid inhibited ester synthesis. However, when fusel alcohols were used as the alcohol substrate, no significant inhibitory effect by butyric acid was observed. Added octanoic acid did not show any adverse effect on the synthesis of corresponding esters. The results suggest that polarity of the reactants determines lipase activity. This study provides the first evidence on the mechanism of immobilised lipase-catalysed ester synthesis in a solvent-free system involving both hydrolysis and esterification.",
        "keywords": [
            "coconut oil",
            "lipase",
            "solvent-free",
            "transesterification",
            "esterification",
            "mechanism"
        ],
        "authors": [
            {
                "name": "Jingcan Sun",
                "org": "National University of Singapore(National University of Singapore),Singapore City,Singapore"
            },
            {
                "name": "Bin Yu",
                "org": "Firmenich Asia Pte. Ltd.(Firmenich Asia Pte Ltd,Firmenich Asia Pte. Ltd.,Firmenich Asia Pte Ltd.),Singapore City,Singapore"
            },
            {
                "name": "Philip Curran",
                "org": "Firmenich Asia Pte. Ltd.(Firmenich Asia Pte Ltd,Firmenich Asia Pte. Ltd.,Firmenich Asia Pte Ltd.),Singapore City,Singapore"
            },
            {
                "name": "Shao-Quan Liu",
                "org": "National University of Singapore(National University of Singapore),Singapore City,Singapore"
            }
        ],
        "venue": "Food chemistry",
        "year": 2013
    },
    "svulamG1": {
        "id": "svulamG1",
        "title": "Growth and fermentation kinetics of a mixed culture of Saccharomyces cerevisiae var. bayanus and Williopsis saturnus var. saturnus at different ratios in longan juice (Dimocarpus longan Lour.)",
        "abstract": "",
        "keywords": [
            "flavour",
            "fermentation"
        ],
        "authors": [
            {
                "name": "thithanhtam trinh",
                "org": "national university of singapore"
            },
            {
                "name": "wei ya woon",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2011
    },
    "CCoTLTTM": {
        "id": "CCoTLTTM",
        "title": "Biocatalytic Conversion of Coconut Oil to Natural Flavor Esters Optimized with Response Surface Methodology",
        "abstract": "Lipase (Lipozyme TL IM)-mediated biocatalysis in a solvent-free system was effectively employed to convert coconut oil and fusel oil to flavor-active octanoic acid esters (mainly ethyl-, butyl-, isobutyl- and (iso)amyl octanoate). Response surface methodology based on five-level-three-factor central composite design was applied to investigate the effects of single and multiple interactive factors on the conversion. Results indicated that the studied independent parameters including reactant molar ratio, enzyme loading and shaking speed were all significant factors that affected the formation of octanoic acid esters during transesterification reaction. According to the developed polynomial model (R 2 = 0.947), the optimum transesterification conditions were determined as follows: molar ratio of 3.25:1 (alcohol/oil), enzyme loading of 16.7 % (wt%) and shaking speed of 160 rpm. Under the optimized reaction conditions an average conversion of 62.0 % was achieved which was in reasonable agreement with the predicted value of 64.1 % and about 9.4 mg of ethyl octanoate, 14.4 mg of isobutyl octanoate, 0.3 mg of butyl octanoate and 49.2 mg of (iso)amyl octanoate were produced per gram of coconut oil.",
        "keywords": [
            "Coconut oil",
            " Flavor esters",
            " Lipase",
            " Fusel oil",
            " Solvent-free transesterification",
            " Biocatalysis"
        ],
        "authors": [
            {
                "name": "jingcan sun",
                "org": "national university of singapore"
            },
            {
                "name": "jin hua chin",
                "org": "national university of singapore"
            },
            {
                "name": "weibiao zhou",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": "Firmenich Asia Pte Ltd,Singapore,Singapore"
            },
            {
                "name": "philip curran",
                "org": "Firmenich Asia Pte Ltd,Singapore,Singapore"
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "Journal of the American Oil Chemists' Society",
        "year": 2012
    },
    "XbjEDJzQ": {
        "id": "XbjEDJzQ",
        "title": "Manipulation of volatile compound transformation in durian wine by nitrogen supplementation",
        "abstract": "",
        "keywords": [
            "volatiles",
            "fermentation",
            "nitrogen"
        ],
        "authors": [
            {
                "name": "pinrou lee",
                "org": "national university of singapore"
            },
            {
                "name": "mingzhan toh",
                "org": "national university of singapore"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "philip curran",
                "org": ""
            },
            {
                "name": "shaoquan liu",
                "org": "national university of singapore"
            }
        ],
        "venue": "International Journal of Food Science and Technology",
        "year": 2013
    },
    "d1vCDIsU": {
        "id": "d1vCDIsU",
        "title": "A systematic study of molecular ion intensity and mass accuracy in low energy electron ionisation using gas chromatography-quadrupole time-of-flight mass spectrometry.",
        "abstract": "Molecular ions, which contain accurate mass information, are valuable for providing elemental composition elucidation. Under the most common electron ionisation (EI) condition (electron energy, 70 eV and temperature, 230 °C), molecular ions are often in relatively low intensities or completely unapparent. In this research, low energy EI source parameters (electron energy and temperature) in a gas chromatography-quadrupole time of flight (GC-QTOF) were systematically studied to evaluate their correlative impact on the intensity and mass accuracy of molecular ions. Lower temperatures were generally associated with higher molecular ion intensities under various EI energies. Apart from compounds with more chemically stable molecular ion structures, the lowest electron energy (12 eV) corresponded to higher intensities. On the other hand, mass accuracy appeared to be mostly constant (≤5 ppm) at different temperatures, while improvement was observed with the use of lower electron energies (12 eV). Moreover, the effect of compound concentration on molecular ion intensity and mass accuracy was studied from 50 to 5000 ppm, and the compound-specific concentration profiles were constructed. Finally, it was found that higher column flow rates corresponded to higher intensities, while the response under 12 eV was higher than that of 70 eV. Mass accuracy remained approximately constant across different flow rates. Therefore, these findings suggest that the use of low energy EI may be a viable approach for the preservation of molecular ions.",
        "keywords": [
            "GC-QTOF",
            "Low energy EI",
            "Mass accuracy",
            "Molecular ion intensity"
        ],
        "authors": [
            {
                "name": "Hazel Lau",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore; Mane SEA Pte Ltd, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Shao Quan Liu",
                "org": "Food Science and Technology Programme, Department of Chemistry, National University of Singapore, S14 Level 5, Science Drive 2, Singapore 117542, Singapore. Electronic address: chmlsq@nus.edu.sg."
            },
            {
                "name": "Lay Peng Tan",
                "org": "Agilent Technologies Singapore (Sales) Pte Ltd, 1 Yishun Avenue 7, Singapore 768923, Singapore."
            },
            {
                "name": "Benjamin Lassabliere",
                "org": "Mane SEA Pte Ltd, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Jingcan Sun",
                "org": "Mane SEA Pte Ltd, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore."
            },
            {
                "name": "Bin Yu",
                "org": "Mane SEA Pte Ltd, 3 Biopolis Drive, #07-17/18/19 Synapse, Singapore 138623, Singapore. Electronic address: gsgpbiy@gmail.com."
            }
        ],
        "venue": "Talanta",
        "year": 2019
    },
    "Kl5dxZ45": {
        "id": "Kl5dxZ45",
        "title": "Characterisation of key odourants in Japanese green tea using gas chromatography-olfactometry and gas chromatography-mass spectrometry",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hui Ru Tan",
                "org": ""
            },
            {
                "name": "Hazel Lau",
                "org": ""
            },
            {
                "name": "Shao Quan Liu",
                "org": ""
            },
            {
                "name": "Lay Peng Tan",
                "org": ""
            },
            {
                "name": "Shunichi Sakumoto",
                "org": ""
            },
            {
                "name": "Benjamin Lassabliere",
                "org": ""
            },
            {
                "name": "Kwong-Chee Leong",
                "org": ""
            },
            {
                "name": "Jingcan Sun",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Lwt - Food Science and Technology",
        "year": 2019
    },
    "1J8jQgeC": {
        "id": "1J8jQgeC",
        "title": "Coordinated schedule-based holing model for bus operation",
        "abstract": "Holding strategy is one of the most commonly used operation control strategies.This paper presents an improved schedule-based holding strategy,in which a support vector machine(S VM)-based model for forecasting the early bus departure time from the following stop,is developed.This strategy judges whether an early bus should be held according to the on-time information of the bus at the current stop and the following stop.Finally,a simulation-based case is used to illustrate the performance of SVM-based model and the improved holding strategy.Results show that the SVM-based model can achieve accurate prediction and provide the improved holding strategy with reliable information.It is shown that the improved holding strategies show better performance than the traditional schedule-based holding strategies.",
        "keywords": [
            "bus operation",
            "support vector machine(SVM)",
            "coordinated schedule-based holding strategy"
        ],
        "authors": [
            {
                "name": "LI Da-ming",
                "org": "Busines Administration,Northeastern University,Shenyang ,China"
            },
            {
                "name": "YU Bin",
                "org": "Transportation Management College,Dalian Maritime University,Dalian ,China"
            }
        ],
        "venue": "Journal of Systems Engineering",
        "year": 2012
    },
    "Wgq8nvyX": {
        "id": "Wgq8nvyX",
        "title": "Dynamic bus travel-time prediction model",
        "abstract": "Effective prediction of bus arrival time is a core for advanced traveler information system.Support vector machines(SVM) are applied to predicting bus travel times.The objective of this paper is to examine the feasibility and applicability of SVM in the vehicle travel time forecasting area.A decay factor is introduced to adjust the weights between new and old data.Also,an adaptive algorithm is used to improve the prediction results.The SVM with the decay factor is tested with the data of the number 23 bus route in Dalian city.Results show that the SVM with the decay factor and the adaptive algorithm has better prediction accuracy and dynamic performance than other existing algorithms.",
        "keywords": [
            "support vector machine",
            "travel time",
            "decay factor",
            "prediction",
            "adaptive algorithm"
        ],
        "authors": [
            {
                "name": "YAO Bao-zhen",
                "org": "School of Civil Engineering & Architecture,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "YANG Cheng-yong",
                "org": "School of Civil Engineering & Architecture,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Transportaition Management,Dalian Maritime University,Dalian ,China"
            }
        ],
        "venue": "Journal of Systems Engineering",
        "year": 2010
    },
    "t3LoloJ6": {
        "id": "t3LoloJ6",
        "title": "Dynamic Extra Buses Scheduling Strategy in Public Transport",
        "abstract": "This paper presents a dynamic extra buses scheduling strategy to improve the transit service of transit routes. In this strategy, in order to decide when to dispatch an extra bus, the service reliability of transit route is assessed firstly. A model aimed at maximizing the benefit of the extra buses scheduling strategy is constructed to determine how many stops extra buses need to skip from the terminal to accommodate passengers at the following stops. A heuristic algorithm is defined and implemented to estimate the service reliability of transit route and to optimize the initial stop of extra buses scheduling strategy. Finally, the strategy is tested on two examples: a simple and a real-life transit route in the Dalian city in China. The results show that the extra buses scheduling strategy based on terminal stops with a reasonable threshold can save 8.01% waiting time of passengers.",
        "keywords": [
            "transit",
            "service reliability assessment",
            "extra buses scheduling strategy",
            "heuristic algorithm"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "keming wang",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "zixuan peng",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "can wang",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "ziyou gao",
                "org": "Beijing Jiaotong Univ, Sch Traff & Transportat, Beijing 100044, Peoples R China"
            },
            {
                "name": "baozhen yao",
                "org": "Dalian Univ Technol, Automot Engn Coll, Dalian 116024, Peoples R China"
            }
        ],
        "venue": "PROMET-TRAFFIC & TRANSPORTATION",
        "year": 2015
    },
    "STNNXRZJ": {
        "id": "STNNXRZJ",
        "title": "Swarm Intelligence in Engineering 2014",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "baozhen yao",
                "org": ""
            },
            {
                "name": "fang zong",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "rui mu",
                "org": ""
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2015
    },
    "MR1Ie8d6": {
        "id": "MR1Ie8d6",
        "title": "Swarm intelligence in mechanical engineering",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Dalian Maritime Univ, Collaborat Innovat Ctr Transport Studies, Dalian, Peoples R China"
            },
            {
                "name": "Gang Chen",
                "org": "Aalborg Univ, Dept Mech & Mfg Engn, Aalborg, Denmark"
            }
        ],
        "venue": "ADVANCES IN MECHANICAL ENGINEERING",
        "year": 2016
    },
    "U5nedwdZ": {
        "id": "U5nedwdZ",
        "title": "Air express network design based on express path choices – Chinese case study",
        "abstract": "Due to the shortage of cargo aircraft, Chinese express companies have to provide transportation services with a hybrid method that consists of â€œrented bellies and self-owned cargo aircraftâ€ . Because the bellies are rented from air passenger companies and because the cargo aircraft are owned by the express companies, it is important for the express companies to use their cargo aircraft as effectively as possible. This paper constructs a bi-level model to optimize the flight transportation network of an express company. The upper model designs the network and allocates the transportation capacity with the objective of minimizing the total transportation cost, and the lower model calculates the link flows in user equilibrium. Data from ShunFeng (SF) Express Company (China) are used to conduct the case study. Using the model outputs, the flows on links and at nodes are analyzed to illustrate the transportation and transshipment situations.",
        "keywords": "",
        "authors": [
            {
                "name": "Shunan Yu",
                "org": "Collaborative Innovation Center for Transport Studies, Dalian Maritime University, Dalian, 116026, PR China"
            },
            {
                "name": "Zhongzhen Yang",
                "org": "Collaborative Innovation Center for Transport Studies, Dalian Maritime University, Dalian, 116026, PR China"
            },
            {
                "name": "Bin Yu",
                "org": "Collaborative Innovation Center for Transport Studies, Dalian Maritime University, Dalian, 116026, PR China"
            }
        ],
        "venue": "Journal of Air Transport Management",
        "year": 2017
    },
    "gnYFntIM": {
        "id": "gnYFntIM",
        "title": "Dynamic Holding Strategy Based on Bus Arrival Time Prediction at Stops",
        "abstract": "Holding strategies are among the most commonly used operation control strategies.The author presents a new holding strategy.Firstly,the strategy determines a held bus by using a support vector machines(SVM) and Kalman filter-based prediction model.Then,in order to determine the optimal holding time,a model aiming to minimize the user costs is developed and a genetic algorithm(GA) is used to optimize the holding time of a held bus at a stop.Finally the presented holding strategy proposed in this study is illustrated with the microscopic simulation model Paramics,and results show that the dynamic holding strategy is effective compared with traditional holding strategy and no control strategy.",
        "keywords": [
            "Dynamic holding strategy",
            "Genetic algorithm",
            "Kalman filter",
            "SVM"
        ],
        "authors": [
            {
                "name": "Baozhen Yao",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            },
            {
                "name": "YU Bin",
                "org": "Management College,Dalian Maritime University,Dalian ,China"
            },
            {
                "name": "Zhongzhen Yang",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            }
        ],
        "venue": "Journal of Beijing University of Technology",
        "year": 2011
    },
    "JKwLef7v": {
        "id": "JKwLef7v",
        "title": "Improved k-nn for Short-Term Traffic Forecasting Using Temporal and Spatial Information",
        "abstract": "<p>This paper proposes an improved <span class=\"equationTd\"><math display=\"inline\" overflow=\"scroll\"><mrow><mi>k</mi></mrow></math></span><span class=\"formulaLabel\"></span>-nearest neighbor (<span class=\"equationTd\"><math display=\"inline\" overflow=\"scroll\"><mrow><mi>k</mi></mrow></math></span><span class=\"formulaLabel\"></span>-nn) model for short-term traffic forecasting and examines its applicability to forecasting for different links and time periods. The traditional <span class=\"equationTd\"><math display=\"inline\" overflow=\"scroll\"><mrow><mi>k</mi></mrow></math></span><span class=\"formulaLabel\"></span>-nn model is adapted by formulating the weighted distance metric and the state vector, which consider both the temporal and spatial information. The adapted model’s performance is examined in a numerical test where the data are derived from global positioning system (GPS) devices in 180 taxis running in Guiyang, China. The test results demonstrate that the model that considers both the temporal and spatial information outperforms models that only consider temporal information and that adaptation of distance metrics could significantly improve the forecasting accuracy. The adapted model shows the promising performance in comparison with the historical average (HA) model and the artificial neural network (ANN) model. The test results also indicate that information from the upstream and the downstream links plays almost the same important role in predicting the traffic conditions at the target link.</p>",
        "keywords": [
            "spatial data",
            "neural networks",
            "nonparametric regression",
            "traffic management",
            "forecasting",
            "k nearest neighbor",
            "global positioning system"
        ],
        "authors": [
            {
                "name": "shanhua wu",
                "org": "Transportation Management College, Dalian Maritime Univ., Dalian 116026, China."
            },
            {
                "name": "zhongzhen yang",
                "org": "Professor, Transportation Management College, Dalian Maritime Univ., Dalian 116026, China (corresponding author)."
            },
            {
                "name": "xiaocong zhu",
                "org": "Transportation Management College, Dalian Maritime Univ., Dalian 116026, China."
            },
            {
                "name": "bin yu",
                "org": "Professor, Transportation Management College, Dalian Maritime Univ., Dalian 116026, China."
            }
        ],
        "venue": "Journal of Transportation Engineering-asce",
        "year": 2014
    },
    "Y7ivIKDr": {
        "id": "Y7ivIKDr",
        "title": "Real-time short turning strategy based on passenger choice behavior",
        "abstract": "AbstractThis article proposed a real-time short turning strategy based on passenger choice behavior to improve transit service for the stops with larger passenger demand in peak periods. A bi-level model is introduced to integrate the real-time control strategy and passenger choice. The upper-level model is an optimal model with the objective of maximizing the reduced waiting time of passengers with the strategy. The lower-level model is an allocation model to calculate passenger demand accurately. The optimization variables include which buses provide short turning services and the start and end stations of each bus. An algorithm is implemented to solve the problem and the effectiveness of the presented strategy is tested with the data of a transit route in Dalian city of China. The results indicate that the real-time short turning strategy based on passenger choice behavior can yield benefits in term of the reduction of passenger waiting time and even the vehicle capacity up.",
        "keywords": "",
        "authors": [
            {
                "name": "Wensi Wang",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian, China;"
            },
            {
                "name": "Zhihui Tian",
                "org": "Automotive Engineering College, Dalian University of Technology, Dalian, China;"
            },
            {
                "name": "Kewang Li",
                "org": "Automotive Engineering College, Dalian University of Technology, Dalian, China;"
            },
            {
                "name": "Bin Yu",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian, China;"
            },
            {
                "name": "Bin Yu",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian, China;"
            }
        ],
        "venue": "Journal of Intelligent Transportation Systems",
        "year": 2019
    },
    "Av7GjdrP": {
        "id": "Av7GjdrP",
        "title": "Bus Travel-Time Prediction with a Forgetting Factor",
        "abstract": "Bus travel-time prediction has drawn a lot of research interests in previous literature. This paper proposes a prediction model for bus travel time based on the support vector machine (SVM) regression method. A forgetting factor is introduced to assign the weight to the recent data resulting from the bus running time-based variable quantities. The Grubbs' test method is applied to remove outliers from the input data. The proposed model is assessed with the data of transit route number 23 in the city of Dalian, China. Results show that the SVM with the forgetting factor and the Grubbs' test method is a powerful tool for bus travel-time prediction. (C) 2014 American Society of Civil Engineers.",
        "keywords": [
            "Prediction",
            "Bus travel time",
            "Support vector machine regression",
            "Forgetting factor",
            "Grubbs' test method"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "Dalian Maritime Univ, Transportat Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "ting ye",
                "org": "Dalian Maritime Univ, Transportat Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "xiaomei tian",
                "org": "Dalian Maritime Univ, Transportat Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "guobao ning",
                "org": "Tongji Univ, Sch Automot, Shanghai 201804, Peoples R China"
            },
            {
                "name": "shiquan zhong",
                "org": "Tianjin Univ, Sch Management & Econ, Tianjin 300072, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF COMPUTING IN CIVIL ENGINEERING",
        "year": 2014
    },
    "CU0lcMhw": {
        "id": "CU0lcMhw",
        "title": "Urban transit hub location optimization based on attractiveness",
        "abstract": "In this paper,a two-stage method of transit hub location optimization is proposed.Firstly, alternative hub locations are determined by evaluating the attractiveness of each alternative location.The attractiveness of alternative location can be obtained by three aspects:the accessibility,the aggregation of transit lines and the layout of transit lines.Based on the alternative hub location set,considering the benefit of passenger and operator,a multi-objective model is presented to design transit hub location in a city. Then,a multi-objective genetic algorithm is also developed to solve the model.Finally,the data of Dalian city is used to validate the two-stage method for transit hub location optimization.The results show that the chosen alternative locations are almost cover main land use of Dalian city by using the attractivenessbased model.This indicates that the attractiveness-based model is a feasible and efficient way to determine alternative hub locations.Furthermore,the solution of the transit hub location optimization accords with the actual conditions of Dalian city.This indicates that the proposed multi-objective model and algorithm can consider the quantity,location and cost of transit hubs.",
        "keywords": [
            "multi-objective optimization",
            "transit hub",
            "alternative hub",
            "attractiveness",
            "location optimization"
        ],
        "authors": [
            {
                "name": "YANG Yang",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "KONG Lu",
                "org": ""
            },
            {
                "name": "SUN Rui-ping",
                "org": ""
            },
            {
                "name": "YANG Zhong-zhen",
                "org": ""
            }
        ],
        "venue": "Systems Engineering-Theory & Practice",
        "year": 2013
    },
    "a8zXb9DF": {
        "id": "a8zXb9DF",
        "title": "Passenger boarding choice prediction at a bus hub with real-time information",
        "abstract": "Providing real-time bus information (e.g. current situation of an arriving bus) to passengers is becoming increasingly possible with the development of transportation information technology, such as intelligent transport systems. When multiple routes can reach a given destination, real-time information could be an important reference for passengers' decision-making regarding which bus to board. This paper presents a method for predicting passengers' boarding choice behaviours on common bus lines at a bus hub with real-time information. To account for the uncertainty in the decision-making process, cloud model theory, which is based on fuzzy sets, was adopted. Data from a bus hub in Dalian city of China are also presented to illustrate the applicability and effectiveness of the proposed method. The results show that providing real-time information could lead to a deviation from passengers' typical choices that are made without real-time information. The proposed model effectively predicts passenger's boarding choices and could be used to improve bus-dispatching models in the future.",
        "keywords": [
            "passenger boarding choice",
            "cloud model",
            "real-time bus information",
            "common bus routes"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "ting li",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "lu kong",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "keming wang",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            },
            {
                "name": "yanxia wu",
                "org": "Dalian Maritime Univ, Transportat Management Coll, Dalian 116026, Peoples R China"
            }
        ],
        "venue": "TRANSPORTMETRICA B-TRANSPORT DYNAMICS",
        "year": 2015
    },
    "2JjLEU97": {
        "id": "2JjLEU97",
        "title": "Transit route network design-maximizing direct and transfer demand density",
        "abstract": "Transit network design is an important part of urban transportation planning. The purpose of this paper is to build on direct traveler density model and extend it to design transit network considering demand density relating to direct demands and transfers, and lengths of routes. The proposed method aiming to maximize demand density of route under some resource constraints divides transit network design problem into three stages, i.e., skeleton route design, main route design and branch route design, based on the objective functions with different transfer coefficients. An ant colony optimization (ACO) is used to solve the model. The model and algorithm are illustrated with data from Dalian city, China and results show that the approach can improve the solution quality if the transfer coefficient is reasonably set. © 2011 Elsevier Ltd.",
        "keywords": [
            "aco",
            "demand density",
            "transfer coefficient",
            "transit network design",
            "network design",
            "objective function",
            "city planning",
            "public transit",
            "ant colony optimization"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            },
            {
                "name": "Zhongzhen Yang",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            },
            {
                "name": "PengHuan Jin",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            },
            {
                "name": "Shanhua Wu",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            },
            {
                "name": "Baozhen Yao",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Transportation Research Part C: Emerging Technologies",
        "year": 2012
    },
    "FrUL4fVZ": {
        "id": "FrUL4fVZ",
        "title": "Transit network optimization based on direct passenger flow density maximization",
        "abstract": "Against the limitation of traditional methods for transit network optimization,a mathematical model is presented aiming to maximize the direct passenger flow density.This model attempts to maximize passenger flow within unit length of transit network and to optimize route directness while maximizing the service coverage.The problems of traditional methods for transit network optimization are analyzed,such as route design along the shortest path and over-long path.The presented model of direct passenger flow density can avoid these problems.With a numerical test,the effectiveness of the model is verified.",
        "keywords": [
            "direct passenger flow density",
            "transit network optimization"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Transportation Management College,Dalian Maritime University,Dalian ,China"
            },
            {
                "name": "YANG Yong-zhi",
                "org": "Transportation Management College,Dalian Maritime University,Dalian ,China"
            },
            {
                "name": "YANG Zhong-zhen",
                "org": "Transportation Management College,Dalian Maritime University,Dalian ,China"
            },
            {
                "name": "JIN Lian-jie",
                "org": "Transportation Management College,Dalian Maritime University,Dalian ,China"
            }
        ],
        "venue": "Journal of Harbin Institute of Technology",
        "year": 2009
    },
    "eAyGid8o": {
        "id": "eAyGid8o",
        "title": "System dynamics based port's landside consolidation system in port cities",
        "abstract": "Based on analysis of structure of the port's landside consolidation system and its cause-and-effect relation,the port's landside consolidation system is divided into three subsystems including economic subsystem,transportation networks subsystem and transport investment subsystem respectively using methodologies of system dynamics,and the SD simulation model is built.Taking Tianjin city as an example,the effects of different investment proportion of land consolidation modes on the port's landside consolidation capacity are analyzed.Results show that transport investment can not make obvious benefits on both the port and port city's economy,except considering the actual situation of the port city's landside consolidation system.",
        "keywords": [
            "system dynamics",
            "landside consolidation system",
            "port city"
        ],
        "authors": [
            {
                "name": "JIANG Yong-lei",
                "org": "Transportation Management College, Dalian Maritime University,Dalian ,China"
            },
            {
                "name": "TIAN Zhi-hui",
                "org": "Transportation Management College, Dalian Maritime University,Dalian ,China"
            },
            {
                "name": "YU Bin",
                "org": "Transportation Management College, Dalian Maritime University,Dalian ,China"
            }
        ],
        "venue": "Journal of Dalian Maritime University",
        "year": 2013
    },
    "HljDGvIe": {
        "id": "HljDGvIe",
        "title": "A data-driven hybrid control framework to improve transit performance",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Wensi Wang",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian 116026, PR China"
            },
            {
                "name": "Jiaming Liu",
                "org": "BDBC, Beihang University, Beijing 100191, PR China"
            },
            {
                "name": "Baozhen Yao",
                "org": "State Key Laboratory of Structural Analysis for Industrial Equipment, School of Automotive Engineering, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Yonglei Jiang",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian 116026, PR China"
            },
            {
                "name": "Yunpeng Wang",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian 116026, PR China"
            },
            {
                "name": "Bin Yu",
                "org": "School of Transportation Engineering, Dalian Maritime University, Dalian 116026, PR China"
            }
        ],
        "venue": "Transportation Research Part C-emerging Technologies",
        "year": 2019
    },
    "bIQdA2qB": {
        "id": "bIQdA2qB",
        "title": "Application of Discrete Mathematics in Urban Transportation System Analysis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "baozhen yao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            },
            {
                "name": "rui mu",
                "org": ""
            },
            {
                "name": "fang zong",
                "org": ""
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2014
    },
    "5WKV0VWS": {
        "id": "5WKV0VWS",
        "title": "The equilibrium location of industrial manufacturing and laborers working in the pan-Pearl River Delta of China",
        "abstract": "",
        "keywords": [
            "quality of life"
        ],
        "authors": [
            {
                "name": "yonglei jiang",
                "org": ""
            },
            {
                "name": "zhongzhen yang",
                "org": ""
            },
            {
                "name": "hanbing zhu",
                "org": ""
            },
            {
                "name": "baozhen yao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Transportation Letters: The International Journal of Transportation Research",
        "year": 2014
    },
    "TEIAFBdc": {
        "id": "TEIAFBdc",
        "title": "Modeling and solutions for optimizing bus frequencies",
        "abstract": "Optimization on bus frequencies of routes plays an important role in bus scheduling.A bus frequency optimization model for a given number of public transportation vehicles on a single transit route is presented,which is aimed to minimize the total cost of passengers.Since the model is an NP-hard problem,which is considered difficult to be solved via traditional methods,a new heuristic algorithm,i.e.the shuffled complex evolution method(SCE-UA) is adopted to solve the model.With data of bus route 408 of Dalian city,the effectiveness of the model and the algorithm is verified.",
        "keywords": [
            "bus route",
            "SCE-UA",
            "frequency"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Transportation management College,Dalian Maritime University,Dalian,,P.R.China;School of Civil and Hydraulic Engineering,Dalian University of Technology,Dalian,China"
            },
            {
                "name": "ZOU Wen-qian",
                "org": "Transportation management College,Dalian Maritime University,Dalian,,P.R.China"
            },
            {
                "name": "SHAO Guang-Cheng",
                "org": "Transportation management College,Dalian Maritime University,Dalian,,P.R.China"
            },
            {
                "name": "YANG Zhong-zhen",
                "org": "Transportation management College,Dalian Maritime University,Dalian,,P.R.China"
            }
        ],
        "venue": "Journal of Harbin Institute of Technology",
        "year": 2009
    },
    "z1Y2ngCt": {
        "id": "z1Y2ngCt",
        "title": "An improved ant colony optimization for vehicle routing problem",
        "abstract": "",
        "keywords": [
            "ant-weight strategy",
            "improved ant colony optimization",
            "mutation operation",
            "vehicle routing problem"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "dalian maritime university"
            },
            {
                "name": "Zhong-zhen Yang",
                "org": "dalian maritime university"
            },
            {
                "name": "Baozhen Yao",
                "org": "beijing jiaotong university"
            }
        ],
        "venue": "European Journal of Operational Research",
        "year": 2009
    },
    "UGKPBKwU": {
        "id": "UGKPBKwU",
        "title": "A decentralized approach to space deconfliction.",
        "abstract": "",
        "keywords": [
            "mobile robots",
            "kinematics",
            "computer science",
            "remotely operated vehicles",
            "probability of detection",
            "telerobotics",
            "path planning",
            "vehicle dynamics"
        ],
        "authors": [
            {
                "name": "Paul Scerri",
                "org": ""
            },
            {
                "name": "Sean Owens",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Katia P. Sycara",
                "org": ""
            }
        ],
        "venue": "Fusion",
        "year": 2007
    },
    "2OxGzyxC": {
        "id": "2OxGzyxC",
        "title": "An Adaptive Social Network for Information Access: Theoretical and Experimental Results",
        "abstract": "We consider a social network of software agents who assist each other in help- ing their users find information. Unlike in most previous approaches, our architec- ture is fully distributed and includes agents who preserve the privacy and autonomy of their users. These agents learn models of each other in terms of expertise (abil- ity to produce correct domain answers) and sociability (ability to produce accurate referrals). We study our framework experimentally to study how the social net- work evolves. Specifically, we find that under our multiagent learning heuristic, the quality of the network improves with interactions; the quality is maximized when both expertise and sociability are considered; pivot agents further improve the quality of the network and have a catalytic effect on its quality even if they are ultimately removed. Moreover, the quality of the network improves when cluster- ing decreases, reflecting the intuition that you need to talk to people outside your close circle to get the best information.",
        "keywords": [
            "software agent",
            "social network"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Mahadevan Venkatraman",
                "org": ""
            },
            {
                "name": "Munindar P. Singh",
                "org": ""
            }
        ],
        "venue": "Applied Artificial Intelligence",
        "year": 2003
    },
    "dncIVwAo": {
        "id": "dncIVwAo",
        "title": "Designing an efficient multimode environmental sensor based on graphene-silicon heterojunction",
        "abstract": "By exploiting the adsorbent gaseous molecules induced changes in intrinsic properties of graphene/silicon (Gr/Si) Schottky junction, the authors report a sensitive, low-power consuming, multimode environmental sensor. By combining an array of Gr/Si Schottky diodes with a differential amplifier circuit, the authors are able to not only differentiate the temperature coefficient and humidity sensing, but also monitor the sun-light exposure time. Our device is particularly sensitive toward humidity in both forward and reverse biased, and works in resistive as well as capacitive mode. Sensitivity of our devices reached to 17%, 45%, 26%, and 32% per relative humidity (%RH) for reverse biased, forward biased, resistive, and capacitive modes, respectively. In the reverse mode, the power consumption is as low as 2 nW. Moreover, our sensor response is highly selective, with sensitivity lower than 1% for other gases present in atmosphere including H-2, O-2, N-2, and CO2. High sensitivity, low-power consumption, multiple operation modes, and high selectivity promises application of our sensor for industrial and home safety, environmental monitoring such as indoor and outdoor air conditions, process monitoring, and others.",
        "keywords": "",
        "authors": [
            {
                "name": "Khurram Shehzad",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Tianjin Shi",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Akeel Qadir",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Xia Wan",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Hongwei Guo",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Ayaz Ali",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Weipeng Xuan",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Hua Xu",
                "org": "Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China"
            },
            {
                "name": "Zhongze Gu",
                "org": "Southeast Univ, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China"
            },
            {
                "name": "Xinsheng Peng",
                "org": "Zhejiang Univ, Coll Mat Sci, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Litao Sun",
                "org": "Southeast Univ, Key Lab MEMS Minist Educ, SEU FEI Nanopico Ctr, Nanjing 210096, Jiangsu, Peoples R China"
            },
            {
                "name": "Qiyuan He",
                "org": "Univ Calif Los Angeles, Dept Chem & Biochem, 405 Hilgard Ave, Los Angeles, CA 90024 USA"
            },
            {
                "name": "Zhen Xu",
                "org": "Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Chao Gao",
                "org": "Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "You-Seung Rim",
                "org": "Sejong Univ, Sch Intelligent Mechatron Engn, 209 Neungdong Ro, Seoul 05006, South Korea"
            },
            {
                "name": "Yaping Dan",
                "org": "Joint Inst Univ Michigan & Shanghai Jiaotong Univ, Shanghai 200240, Peoples R China"
            },
            {
                "name": "Tawfique Hasan",
                "org": "Univ Cambridge, Cambridge Graphene Ctr, Cambridge CB3 0FA, England"
            },
            {
                "name": "Pingheng Tan",
                "org": "Chinese Acad Sci, Inst Semicond, State Key Lab Superlattices & Microstruct, Beijing 100083, Peoples R China"
            },
            {
                "name": "Erping Li",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Wenyan Yin",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Zhiyuan Cheng",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "SUNY Albany, Coll Nanoscale Sci & Engn, Albany, NY 12203 USA"
            },
            {
                "name": "Yang Xu",
                "org": "Zhejiang Univ, Key Lab Micronano Elect & Smart Syst Zhejiang Pro, Coll Informat Sci & Elect Engn, Hangzhou 310027, Zhejiang, Peoples R China"
            },
            {
                "name": "Jikui Luo",
                "org": "Univ Bolton, Inst Renewable Energy & Environm Technol, Bolton BL3 5AB, England"
            },
            {
                "name": "Xiangfeng Duan",
                "org": "Univ Calif Los Angeles, Dept Chem & Biochem, 405 Hilgard Ave, Los Angeles, CA 90024 USA"
            }
        ],
        "venue": "ADVANCED MATERIALS TECHNOLOGIES",
        "year": 2017
    },
    "xS6OAGn6": {
        "id": "xS6OAGn6",
        "title": "Proactive information delivery and fusion in mobile sensor networks",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Paul Scerri",
                "org": ""
            },
            {
                "name": "Katia Sycara",
                "org": ""
            },
            {
                "name": "Yang Xu",
                "org": ""
            },
            {
                "name": "Michael Lewis",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2005
    },
    "mvG5s1Xc": {
        "id": "mvG5s1Xc",
        "title": "Scalable and reliable data delivery in mobile ad hoc sensor networks",
        "abstract": "This paper studies scalable data delivery algorithms in mobile ad hoc sensor networks with node and link failures. Many algorithms have been developed for data delivery and fusion in static microsensor networks, but most of them are not appropriate for mobile sensor networks due to their heavy traffic and long latency. In this paper we propose an efficient and robust data delivery algorithm for distributed data fusion in mobile ad hoc sensor networks, where each node controls its data flows and learns routing decisions solely based on their local knowledge. We analyze the localized algorithm in a formal model and validate our model using simulations. The experiments indicate that controlled data delivery processes significantly increase the probability of relevant data being fused in the network even with limited local knowledge of each node and relatively small hops of data delivery.",
        "keywords": [
            "delivery algorithm",
            "relevant data",
            "paper studies scalable data",
            "reliable data delivery",
            "data fusion",
            "controlled data delivery",
            "data delivery",
            "data flow",
            "formal model",
            "robust data delivery algorithm",
            "mobile sensor network",
            "local knowledge",
            "sensor network",
            "reinforcement learning"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Paul Scerri",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Katia Sycara",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Yang Xu",
                "org": "University of Pittsburgh, Pittsburgh, PA"
            },
            {
                "name": "Michael Lewis",
                "org": "University of Pittsburgh, Pittsburgh, PA"
            }
        ],
        "venue": "AAMAS",
        "year": 2006
    },
    "kyOzGcW6": {
        "id": "kyOzGcW6",
        "title": "Towards Flexible Coordination of Large Scale Multi-Agent Teams",
        "abstract": "As a paradigm for coordinating cooperative agents in dynamic environments, teamwork has been shown to be capable of leading to flexible and robust behavior. However, when teamwork is applied to the problem of building teams with hundreds of members, its previously existing, fundamental limitations become apparent. In this paper, we address the limitations of existing models as they apply to very large agent teams. We develop algorithms aimed at flexible and efficient coordination, applying a decentralized social network topology for team organization and the abstract coordination behaviors of Team Oriented Plans (TOPs). From this basis, we present a model to organize a team into dynamically evolving subteams, in order to flexibly coordinate the team. Additionally, we put forward a novel approach to sharing information within large teams, which provides for targeted, efficient information delivery with a localized reasoning process model built on previously incoming information. We have developed domain- independent software proxies, with which we demonstrate teams of an order of magnitude larger than those previously discussed in known published work. We implement the results of our approach, demonstrating its ability to handle the challenges of coordinating large agent teams.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Xu",
                "org": "University of Pittsburgh School of Information Sciences Pittsburgh"
            },
            {
                "name": "Elizabeth Liao",
                "org": "Carnegie Mellon University School of Computer Science USA"
            },
            {
                "name": "Paul Scerri",
                "org": "Carnegie Mellon University School of Computer Science USA"
            },
            {
                "name": "Bin Yu",
                "org": "Carnegie Mellon University School of Computer Science USA"
            },
            {
                "name": "Mike Lewis",
                "org": "School of Information Sciences|University of Pittsburgh"
            },
            {
                "name": "Katia Sycara",
                "org": "Carnegie Mellon University School of Computer Science USA"
            }
        ],
        "venue": "",
        "year": 2006
    },
    "6wm3JV3D": {
        "id": "6wm3JV3D",
        "title": "Trust and reputation management in a small-world network",
        "abstract": "Successful commerce relies heavily upon the reputations that the different parties acquire through their dealings with each other. We view an e-commerce community as a social network, which supports reputations both for expertise (providing good service) and helpfulness (providing good referrals). We study the small-world phenomena such as the emergence of subcommunities, and pivot vertices (which link different subcommunities) in the social network, and discovered that the quality of the network improves with the presence of a pivot",
        "keywords": [
            "e-commerce community",
            "small-world phenomenon",
            "social network",
            "small-world network",
            "pivot vertices",
            "pivot vertex",
            "good service",
            "multi-agent systems",
            "trust management",
            "good referrals",
            "different party",
            "multiagent systems",
            "successful commerce",
            "electronic commerce",
            "subcommunities",
            "different sub-communities",
            "reputation management",
            "e commerce",
            "intelligent networks",
            "business",
            "multi agent systems",
            "small world network",
            "computer science",
            "sociology"
        ],
        "authors": [
            {
                "name": "Venkatraman, M.",
                "org": "Dept. of Comput. Sci., North Carolina State Univ., Raleigh, NC, USA|c|"
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Singh, M.P.",
                "org": ""
            }
        ],
        "venue": "ICMAS",
        "year": 2000
    },
    "hiyWy4Kf": {
        "id": "hiyWy4Kf",
        "title": "An integrated token-based algorithm for scalable coordination",
        "abstract": "Efficient coordination among large numbers of heterogeneous agents promises to revolutionize the way in which some complex tasks, such as responding to urban disasters can be performed. However, state of the art coordination algorithms are not capable of achieving efficient and effective coordination when a team is very large. Building on recent successful token-based algorithms for task allocation and information sharing, we have developed an integrated and efficient approach to effective coordination of large scale teams. We use tokens to encapsulate anything that needs to be shared by the team, including information, tasks and resources. The tokens are efficiently routed through the team via the use of local decision theoretic models. Each token is used to improve the routing of other tokens leading to a dramatic performance improvement when the algorithms work together. We present results from an implementation of this approach which demonstrates its ability to coordinate large teams.",
        "keywords": [
            "efficient approach",
            "efficient coordination",
            "integrated token-based algorithm",
            "large team",
            "art coordination algorithm",
            "dramatic performance improvement",
            "large number",
            "complex task",
            "effective coordination",
            "information sharing",
            "large scale team",
            "scalable coordination",
            "negotiation"
        ],
        "authors": [
            {
                "name": "Yang Xu",
                "org": "University of Pittsburgh"
            },
            {
                "name": "Paul Scerri",
                "org": "Carnegie Mellon University"
            },
            {
                "name": "Bin Yu",
                "org": "Carnegie Mellon University"
            },
            {
                "name": "Steven Okamoto",
                "org": "Carnegie Mellon University"
            },
            {
                "name": "Michael Lewis",
                "org": "University of Pittsburgh"
            },
            {
                "name": "Katia Sycara",
                "org": "Carnegie Mellon University"
            }
        ],
        "venue": "AAMAS",
        "year": 2005
    },
    "j2E74UfM": {
        "id": "j2E74UfM",
        "title": "Synergistic integration of agent technologies for military simulation",
        "abstract": "To perform large-scale coordination in real-world environments requires that many individually complex technologies come together to form integrated solutions. We present an application where several key technologies are integrated into a unified system via a multiagent infrastructure. We show how the synergistic behavior among heterogeneous technologies results in a significant improvement over the performance of the individual technologies acting alone. Critical extensions were required to the language describing required behavior to allow the pieces to work together. Initial experimental results show system performance on a task of coordinating a military convoy in an adversarial environment was significantly improved when all technologies worked together. However, experiments with a human user in the loop showed that significant advances must still be made before such systems can be fielded in the real-world.",
        "keywords": [
            "synergistic integration",
            "unified system",
            "significant advance",
            "complex technology",
            "system performance",
            "heterogeneous technologies result",
            "military simulation",
            "real-world environment",
            "integrated solution",
            "agent technology",
            "adversarial environment",
            "synergistic behavior",
            "significant improvement",
            "simulation"
        ],
        "authors": [
            {
                "name": "Sean Owens",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Paul Scerri",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Robin Glinton",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Bin Yu",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            },
            {
                "name": "Katia Sycara",
                "org": "Carnegie Mellon University, Pittsburgh, PA"
            }
        ],
        "venue": "AAMAS",
        "year": 2006
    },
    "R8UQlz75": {
        "id": "R8UQlz75",
        "title": "Detecting deception in reputation management",
        "abstract": "We previously developed a social mechanism for distributed reputation management, in which an agent combines testimonies from several witnesses to determine its ratings of another agent. However, that approach does not fully protect against spurious ratings generated by malicious agents. This paper focuses on the problem of deception in testimony propagation and aggregation. We introduce some models of deception and study how to efficiently detect deceptive agents following those models. Our approach involves a novel application of the well-known weighted majority technique to belief function and their aggregation. We describe simulation experiments to study the number of apparently accurate witnesses found in different settings, the number of witnesses on prediction accuracy, and the evolution of trust networks.",
        "keywords": [
            "social mechanism",
            "deceptive agent",
            "detecting deception",
            "simulation experiment",
            "reputation management",
            "different setting",
            "prediction accuracy",
            "novel application",
            "belief function",
            "malicious agent",
            "accurate witness",
            "reputation",
            "difference set",
            "weighted majority algorithm"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "North Carolina State University, Raleigh, NC"
            },
            {
                "name": "Munindar P. Singh",
                "org": "North Carolina State University, Raleigh, NC"
            }
        ],
        "venue": "AAMAS",
        "year": 2003
    },
    "w16rhqAu": {
        "id": "w16rhqAu",
        "title": "Uncertain Information Fusion for Force Aggregation and Classification in Airborne Sensor Networks",
        "abstract": "The paper describes airborne sensor networks for tar- get tracking and identification in military applications. The raw information about targets from airborne sen- sors is uncertain and often noisy. One challenge in air- borne sensor networks is how to effectively fuse enor- mous amounts of uncertain and noisy information for better battlefield situation assessment. In this paper we present a novel approach to military force aggre- gation and classification using Dempster-Shafer theory and doctrinal templates. Our approach helps comman- ders understand operational pictures of the battlefield, e.g., enemy force levels and deployment, and make bet- ter decisions than adversaries in the battlefield. A sam- ple application of our approach is illustrated in the sim- ulated testbed OTBSAF and RETSINA system.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "School of Computer Science|Carnegie Mellon University"
            },
            {
                "name": "Katia Sycara",
                "org": "School of Computer Science|Carnegie Mellon University"
            },
            {
                "name": "Joseph Giampapa",
                "org": "School of Computer Science|Carnegie Mellon University"
            },
            {
                "name": "Sean Owens",
                "org": "School of Computer Science|Carnegie Mellon University"
            }
        ],
        "venue": "",
        "year": 0
    },
    "0f1HLTRc": {
        "id": "0f1HLTRc",
        "title": "Emergence of agent-based referral networks",
        "abstract": "We consider the problem of finding desirable services and sources of information in distributed multiagent systems. Traditional solutions, such as centralized directories, may be inaccurate and may often be unavailable in such settings. Therefore, the only way agents can find the right agents is through referrals. In order to make the referrals effective, the agents must adaptively select the agents with whom they interact. This adaptivity leads to the emergence of referral networks among agents. We study this network experimentally to see the emergence of social structures and the evolution of such structures under different scenarios.",
        "keywords": [
            "social structure",
            "centralized directory",
            "traditional solution",
            "right agent",
            "referral network",
            "agent-based referral network",
            "multiagent system",
            "desirable service",
            "different scenario",
            "software agents",
            "software agent"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "North Carolina State University, Raleigh, NC"
            },
            {
                "name": "Munindar P. Singh",
                "org": "North Carolina State University, Raleigh, NC"
            }
        ],
        "venue": "AAMAS",
        "year": 2002
    },
    "MA4KcDi0": {
        "id": "MA4KcDi0",
        "title": "Searching social networks",
        "abstract": "A referral system is a multiagent system whose member agents are capable of giving and following referrals. The specific cases of interest arise where each agent has a user. The agents cooperate by giving and taking referrals so each can better help its user locate relevant information. This use of referrals mimics human interactions and can potentially lead to greater effectiveness and efficiency than in single-agent systems.Existing approaches consider what referrals may be given and treat the referring process simply as path search in a static graph. By contrast, the present approach understands referrals as arising in and influencing dynamic social networks, where the agents act autonomously based on local knowledge. This paper studies strategies using which agents may search dynamic social networks. It evaluates the proposed approach empirically for a community of AI scientists (partially derived from bibliographic data). Further, it presents a prototype system that assists users in finding other users in practical social networks.",
        "keywords": [
            "prototype system",
            "knowledge management",
            "present approach",
            "multiagent system",
            "social networks",
            "path search",
            "dynamic social network",
            "referral system",
            "ai scientist",
            "single-agent system",
            "practical social network",
            "proposed approach empirically",
            "referral systems",
            "local knowledge",
            "social network",
            "human interaction",
            "design"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Munindar P. Singh",
                "org": ""
            }
        ],
        "venue": "Autonomous Agents & Multiagent Systems/Agent Theories, Architectures, and Languages",
        "year": 2003
    },
    "rFQ0aaKI": {
        "id": "rFQ0aaKI",
        "title": "An integrated approach to high-level information fusion",
        "abstract": "In today's fast paced military operational environment, vast amounts of information must be sorted out and fused not only to allow commanders to make situation assessments, but also to support the generation of hypotheses about enemy force disposition and enemy intent. Current information fusion technology has the following two limitations. First, current approaches do not consider the battlefield context as a first class entity. In contrast, we consider situational context in terms of terrain analysis and inference. Second, there are no integrated and implemented models of the high-level fusion process. This paper describes the HiLIFE (High-Level Information Fusion Environment) computational framework for seamless integration of high levels of fusion (levels 2, 3 and 4). The crucial components of HiLIFE that we present in this paper are: (1) multi-sensor fusion algorithms and their performance results that operate in heterogeneous sensor networks to determine not only single targets but also force aggregates, (2) computational approaches for terrain-based analysis and inference that automatically combine low-level terrain features (such as forested areas, rivers, etc.) and additional information, such as weather, and transforms them into high-level militarily relevant abstractions, such as NO-GO, SLOW-GO areas, avenues of approach, and engagement areas, (3) a model for inferring adversary intent by mapping sensor readings of opponent forces to possible opponent goals and actions, and (4) sensor management for positioning intelligence collection assets for further data acquisition. The HiLIFE framework closes the loop on information fusion by specifying how the different components can computationally work together in a coherent system. Furthermore, the framework is inspired by a military process, the Intelligence Preparation of the Battlefield, that grounds the framework in practice. HiLIFE is integrated with a distributed military simulation system, OTBSAF, and the RETSINA multi-agent infrastructure to provide agile and sophisticated reasoning. In addition, the paper presents validation results of the automated terrain analysis that were obtained through experiments using military intelligence Subject Matter Experts (SMEs).",
        "keywords": [
            "high-level fusion",
            "integrated approach",
            "intent inference",
            "computational framework",
            "high-level fusion process",
            "current information fusion technology",
            "multi-sensor fusion algorithm",
            "hilife framework",
            "additional information",
            "military operational environment",
            "military process",
            "information fusion",
            "integrated framework",
            "military intelligence",
            "high-level information fusion",
            "sensor fusion",
            "data acquisition",
            "subject matter expert",
            "situation assessment"
        ],
        "authors": [
            {
                "name": "Katia Sycara",
                "org": "School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA"
            },
            {
                "name": "Robin Glinton",
                "org": "School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA"
            },
            {
                "name": "Bin Yu",
                "org": "School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA"
            },
            {
                "name": "Joseph A. Giampapa",
                "org": ""
            },
            {
                "name": "Sean Owens",
                "org": "School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA"
            },
            {
                "name": "Michael Lewis",
                "org": ""
            },
            {
                "name": "Charles E. Grindle",
                "org": ""
            }
        ],
        "venue": "Information Fusion",
        "year": 2009
    },
    "FvBRhozS": {
        "id": "FvBRhozS",
        "title": "An evidential model of distributed reputation management",
        "abstract": "For agents to function effectively in large and open networks, they must ensure that their correspondents, i.e., the agents they interact with, are trustworthy. Since no central authorities may exist, the only way agents can find trustworthy correspondents is by collaborating with others to identify those whose past behavior has been untrustworthy. In other words, finding trustworthy correspondents reduces to the problem of distributed reputation management.Our approach adapts the mathematical theory of evidence to represent and propagate the ratings that agents give to their correspondents. When evaluating the trustworthiness of a correspondent, an agent combines its local evidence (based on direct prior interactions with the correspondent) with the testimonies of other agents regarding the same correspondent. We experimentally studied this approach to establish that some important properties of trust are captured by it.",
        "keywords": [
            "important property",
            "trustworthy correspondent",
            "reputation management",
            "evidential model",
            "past behavior",
            "open network",
            "mathematical theory",
            "local evidence",
            "direct prior interaction",
            "central authority"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "North Carolina State University, Raleigh, NC"
            },
            {
                "name": "Munindar P. Singh",
                "org": "North Carolina State University, Raleigh, NC"
            }
        ],
        "venue": "AAMAS",
        "year": 2002
    },
    "u3Q0Octl": {
        "id": "u3Q0Octl",
        "title": "A dynamic pricing mechanism for P2P referral systems",
        "abstract": "Most existing research on peer-to-peer systems focuses on protocol design. In this paper, we consider the issue of free riding in peer-to-peer referral systems. Free riders are agents that refuse either to answer a query or to give referrals. Free riding is detrimental to the system, since it may prevent requesters from finding high quality providers efficiently. To mitigate the issue of free riding, we propose a dynamic pricing mechanism to motivate the agents to behave rationally. Service providers learn appropriate prices of referrals and answers in order to maximize their payoffs through stochastic iterative learning algorithms.",
        "keywords": [
            "protocol design",
            "high quality provider",
            "free rider",
            "dynamic pricing mechanism",
            "p2p referral systems",
            "peer-to-peer referral system",
            "existing research",
            "peer-to-peer system",
            "service provider",
            "appropriate price",
            "stochastic iterative",
            "dynamic pricing",
            "free riding",
            "quality of service",
            "pricing",
            "p2p",
            "control systems",
            "protocols",
            "stochastic processes",
            "computer science"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Carnegie Mellon University"
            },
            {
                "name": "Cuihong Li",
                "org": "Carnegie Mellon University"
            },
            {
                "name": "Munindar P. Singh",
                "org": "North Carolina State University"
            },
            {
                "name": "Katia Sycara",
                "org": "Carnegie Mellon University"
            }
        ],
        "venue": "AAMAS",
        "year": 2004
    },
    "S86facfF": {
        "id": "S86facfF",
        "title": "Distributed Reputation Management for Electronic Commerce",
        "abstract": "Abstract: This paper considers the problem of automatically collecting ratings about a given party fromothers. Our approach involves a distributed agent architecture and adapts the mathematical theoryof evidence to represent and propagate the ratings that participants give to each other. When evaluatingthe trustworthiness of a given party, a peer combines its local evidence (based on direct priorinteractions with the party) with the testimonies of others regarding the same party. This approach...",
        "keywords": [
            "trust networks",
            "electronic commerce",
            "distributed reputation management"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Munindar P. Singh",
                "org": ""
            }
        ],
        "venue": "Computational Intelligence",
        "year": 2002
    },
    "y0upMfYs": {
        "id": "y0upMfYs",
        "title": "A POMDP Approach to Token-Based Team Coordination",
        "abstract": "Ecient coordination among large numbers of heterogeneous agents promises to revolutionize the way in which some com- plex tasks, such as responding to urban disasters can be per- formed. Token-based approaches have shown to be a novel and promising way for such coordination. However, previ- ous token-based algorithms were built on heuristics and did not explicitly consider utilities related to token movements or changes in team states. In this paper we put forward an algorithm that uses team rewards to improve token rout- ing decisions. The ideal solution of this token movement model is a centralized Markov Decision Process (MDP) with joint activity. Unfortunately, the assumptions underlying this model are not feasible for large team coordination and we have to make several approximations. First, we decen- tralize the centralized MDP as a set of standard MDPs with independent individual activities. Then this MDP is approx- imated by a Partially Observable Markov Decision Process (POMDP) because agents in a large team may not know the exact states of their teammates or that of the environment. A logical team organization is imposed to limit the token passing among one agent and its neighbors. Belief states of the POMDP model are eciently estimated using Monte Carlo sampling process.",
        "keywords": [
            "monte carlo sampling",
            "markov decision process"
        ],
        "authors": [
            {
                "name": "Yang Xu",
                "org": "University of Pittsburgh|Carnegie Mellon University"
            },
            {
                "name": "Paul Scerri",
                "org": "University of Pittsburgh|Carnegie Mellon University"
            },
            {
                "name": "Bin Yu",
                "org": "University of Pittsburgh|Carnegie Mellon University"
            },
            {
                "name": "Michael Lewis",
                "org": "University of Pittsburgh|Carnegie Mellon University"
            },
            {
                "name": "Katia Sycara",
                "org": "University of Pittsburgh|Carnegie Mellon University"
            }
        ],
        "venue": "Adaptive Agents and Multi-Agents Systems",
        "year": 2005
    },
    "g2AqyoZq": {
        "id": "g2AqyoZq",
        "title": "A Social Mechanism of Reputation Management in Electronic Communities",
        "abstract": " rust is important wherever agents must interact. We considerthe important case of interactions in electronic communities, wherethe agents assist and represent principal entities, such as people and businesses. ",
        "keywords": [
            "social mechanism",
            "electronic communities",
            "reputation management"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Munindar P. Singh",
                "org": ""
            }
        ],
        "venue": "CIA",
        "year": 2000
    },
    "t0wPclJV": {
        "id": "t0wPclJV",
        "title": "Uncertain Information Fusion for Force Aggregation and Classification in",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "airborne sensor networks",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "katia sycara",
                "org": ""
            },
            {
                "name": "joseph a giampapa",
                "org": ""
            },
            {
                "name": "sean owens",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "zYWRLDjX": {
        "id": "zYWRLDjX",
        "title": "Incentive mechanisms for peer-to-peer systems",
        "abstract": "Most of the existing research in peer-to-peer systems focuses on protocol design and doesn’t consider the rationality of each peer. One phenomenon that should not be ignored is free riding. Some peers simply consume system resources but contribute nothing to the system. In this paper we present an agent-based peer-to-peer system, in which each peer is a software agent and the agents cooperate to search the whole system through referrals. We present a static and a dynamic pricing mechanism to motivate each agent to behave rationally while still achieving good overall system performance. We study the behavior of the agents under two pricing mechanisms and evaluate the impact of free riding using simulations.",
        "keywords": [
            "software agent",
            "system performance",
            "free riding"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science, North Carolina State University, Raleigh, NC"
            },
            {
                "name": "Munindar P. Singh",
                "org": "Department of Computer Science, North Carolina State University, Raleigh, NC"
            }
        ],
        "venue": "AP2PC",
        "year": 2003
    },
    "mWPc1biJ": {
        "id": "mWPc1biJ",
        "title": "Extending the OneSAF Testbed into a C4ISR Test Bed",
        "abstract": "This paper describes how the modeling and simulation environment of the OneSAF Testbed Baseline (OTB) v1.0 has been extended to enable the testing of heterogeneous algorithms that are being designed for real world Command, Control, Communications, Computers, Intelligence, Surveillance, Reconnaissance (C4ISR) applica- tions, such as the automated performance of high-level Information Fusion, the automation of the development and analysis of Courses of Action (COAs), the automation of the Intelligence Preparation of the Battleeld (IPB) process, and the automated development of the Modify, Combine, Obstacle Overlay (MCOO), to name a few. This has been accomplished by building an architecture that extends functional and logical components of the OTB system in six ways. One of those extensions is based on the reuse of the OTB Compact Terrain Database (CTDB). The other ve extensions are: (1) the addition of the RETSINA-OTB Bridge for the real-time query and control of OTB entities via TCP-based messages, (2) the addition of the SAF Broker Agent and the SAF Manager Agent to transform OTB Distributed Interactive Simulation (DIS) entity state Protocol Data Units (PDUs) into entity state TCP messages for interoperability with a TCP-based virtual reality (VR) modeling and simulation system, (3) the addition of new DIS-based sensor entities, SARSim, GMTISim ,a ndEOSim, and their associ- ated TCP-based Sim Manager Agents, for interoperation with Command and Control (C2) algorithms, (4) the modication of the line-oriented OTB command parser to permit supervised, on-line \\batch-mode\" human and software agent interactions with OTB, and (5) the implementation of an o-line Batch Mode Control Agent that permits the unsupervised conguration and control, state and execution monitoring of OTB simulations via the RETSINA-OTB Bridge. This paper describes these extensions and other data that is accessed from OTB for the",
        "keywords": [],
        "authors": [
            {
                "name": "Joseph A. Giampapa",
                "org": ""
            },
            {
                "name": "Katia Sycara",
                "org": ""
            },
            {
                "name": "Sean Owens",
                "org": ""
            },
            {
                "name": "Robin Glinton",
                "org": ""
            },
            {
                "name": "Young-Woo Seo",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Charles E. Grindle",
                "org": ""
            },
            {
                "name": "Michael Lewis",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "77g4RrUA": {
        "id": "77g4RrUA",
        "title": "The MARS Adaptive Social Network for Information Access: Architecture and Experimental Results",
        "abstract": "Conventional techniques for finding information on the web are time-consuming and often yield unreliable results. This has led to renewed interest in referral systems, which support the interactions of people with others by directing users toward others who might have the answers they seek. We consider a social network of agents who assist each other in helping their users find information. Unlike in most previous approaches, our architec- ture is fully distributed and includes agents who preserve the privacy and autonomy of their users. These agents learn models of each other in terms of expertise (ability to produce cor- rect domain answers), and sociability (ability to produce accurate referrals). We study this framework experimentally to see the effects that the different variables have on each other. Specifically , we find that under our multiagent learning heuristic, the quality of the network improves with time; the quality is maximized when both expertise and sociability are con- sidered during learning and querying; pivot agents (who relate different subcommunities) further improve the quality of the network and have a catalytic effect on its quality even if they are ultimately removed. Recall that conventional approaches to collaboration empha- size clustering the agents. By contrast, we find that the quality of the network improves when clustering decreases, reflecting the intuition that you need to talk to people outside your close circle to get the best information.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science|North Carolina State University|Main Campus Drive Raleigh"
            },
            {
                "name": "Mahadevan Venkatraman",
                "org": "Department of Computer Science|North Carolina State University|Main Campus Drive Raleigh"
            },
            {
                "name": "Munindar P. Singh",
                "org": "Department of Computer Science|North Carolina State University|Main Campus Drive Raleigh"
            }
        ],
        "venue": "Applied Artificial Intelligence",
        "year": 2000
    },
    "priMjEvm": {
        "id": "priMjEvm",
        "title": "Extending the ONESAF Testbed into a C4ISR Testbed",
        "abstract": "This article describes how the modeling and simulation environment of the OneSAF Testbed Baseline (OTB) v1.0 has been extended to enable the testing of heterogeneous algorithms that are being designed for real-world C4ISR applications. This has been accomplished by building an architecture that extends functional and logical components of the OTB system in the following ways: the use of the OTB Compact Terrain Database for terrain analysis and preliminary threat assessment, the addition of the RETSINA-OTB Bridge for the real-time query and control of OTB entities, and the addition of new DIS-based sensor entities for interoperation with Command and Control algorithms, to name a few. This article illustrates how to make a few small but general extensions to a modeling and simulation system to create a larger testbed system with minimum impact on the native system and with great potential for the range of applications that can exploit it.",
        "keywords": [
            "OTB system",
            "multi-agent systems",
            "otb",
            "larger testbed system",
            "OneSAF Testbed Baseline",
            "multi-level information fusion",
            "C4ISR application",
            "native system",
            "simulation environment",
            "retsina",
            "terrain analysis",
            "OTB Compact Terrain Database",
            "simulation system",
            "OTB entity",
            "Control algorithm"
        ],
        "authors": [
            {
                "name": "Joseph A. Giampapa",
                "org": "The Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890"
            },
            {
                "name": "Katia Sycara",
                "org": "The Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890"
            },
            {
                "name": "Sean Owens",
                "org": "The Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890"
            },
            {
                "name": "Robin Glinton",
                "org": "The Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890"
            },
            {
                "name": "Young-Woo Seo",
                "org": "The Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890"
            },
            {
                "name": "Bin Yu",
                "org": "The Robotics Institute, Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh, PA 15213-3890"
            },
            {
                "name": "Charles E. Grindle",
                "org": "School of Information Sciences, University of Pittsburgh, Pittsburgh, PA 15213"
            },
            {
                "name": "Michael Lewis",
                "org": "School of Information Sciences, University of Pittsburgh, Pittsburgh, PA 15213"
            }
        ],
        "venue": "Simulation",
        "year": 2004
    },
    "DlS0opnC": {
        "id": "DlS0opnC",
        "title": "Learning the Quality of Sensor Data in Distributed Decision Fusion.",
        "abstract": "The problem of decision fusion has been studied for distributed sensor systems in the past two decades. Various techniques have been developed for either binary or multiple hypotheses decision fusion. However, most of them do not address the challenges that come with the changing quality of sensor data. In this paper we investigate adaptive decision fusion rules for multiple hypotheses within the framework of Dempster-Shafer theory. We provide a novel learn- ing algorithm for determining the quality of sensor data in the fusion process. In our approach each sen- sor actively learns the quality of information from difierent sensors and updates their reliabilities us- ing the weighted majority technique. Several exam- ples are provided to show the efiectiveness of our approach.",
        "keywords": [
            "reliability",
            "sensor fusion",
            "fuses",
            "quality of information",
            "multiagent systems",
            "active learning",
            "system testing",
            "robot kinematics",
            "dempster shafer theory",
            "computer science",
            "decision theory"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "carnegie mellon university"
            },
            {
                "name": "Katia P. Sycara",
                "org": "carnegie mellon university"
            }
        ],
        "venue": "Fusion",
        "year": 2006
    },
    "T9HbhlBg": {
        "id": "T9HbhlBg",
        "title": "Community-based service location",
        "abstract": "",
        "keywords": [
            "community-based service location"
        ],
        "authors": [
            {
                "name": "Munindar P. Singh",
                "org": "North Carolina State Univ."
            },
            {
                "name": "Bin Yu",
                "org": "North Carolina State Univ."
            },
            {
                "name": "Mahadevan Venkatraman",
                "org": "iScale, Inc., Mountain View, CA"
            }
        ],
        "venue": "Commun. ACM",
        "year": 2001
    },
    "1Jq6ON01": {
        "id": "1Jq6ON01",
        "title": "Quantum and thermo-mechanical noise squeezing in nanoresonators: A comparative study",
        "abstract": "Based on theoretical modeling, we performed comprehensive investigation on the quantum and thermomechanical noise squeezing effect in nanoresonators made by two platform material systems: silicon and graphene. We discovered that quantum noise squeezing plays an important role in the effort to improve signal-to-noise ratio in graphene-based nanoresonators. The research suggests a viable strategy for implementing graphene-based nanoscale transducers with ultra-high sensitivity that can be potentially utilized to detect a variety of sensing targets, including atomic force, single biological molecule, and gravitational wave. © 2012 American Institute of Physics.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Xu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Kaicheng Zhu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Sheping Yan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Zhonghe Jin",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yuelin Wang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Hongsheng Chen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "J. K. Luo",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "University at Albany State University of New York(University at Albany,State University of New York at Albany,State University of New York),Albany,United States"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2012
    },
    "ryOflpS6": {
        "id": "ryOflpS6",
        "title": "Incentive Mechanisms for Agent-Based Peer-to-Peer Systems",
        "abstract": "Most of the existing research in peer-to-peer systems focuses on pro- tocol design and doesn't consider the rationality of each peer. One phenomenon that should not be ignored is free riding. Some peers simply consume system resources but contribute nothing to the system. In this paper we present an agent- based peer-to-peer system, in which each peer is a software agent and the agents cooperate to search the whole system through referrals. We present a static and a dynamic pricing mechanism to motivate each agent to behave rationally while still achieving good overall system performance. We study the behavior of the agents under two pricing mechanisms and evaluate the impact of free riding us- ing simulations.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science|North Carolina State University"
            },
            {
                "name": "Munindar P. Singh",
                "org": "Department of Computer Science|North Carolina State University"
            }
        ],
        "venue": "Agents and Peer-to-Peer Computing",
        "year": 0
    },
    "hfpVU4Bi": {
        "id": "hfpVU4Bi",
        "title": "An agent-based approach to knowledge management",
        "abstract": "Traditional approaches to knowledge management are essentially limited to document management. However, much knowledge in organizations or communities resides in an informal social network and may be accessed only by asking the right people. This paper describes MARS, a multiagent referral system for knowledge management. MARS assigns a software agent to each user. The agents facilitate their users' interactions and help manage their personal social networks. Moreover, the agents cooperate with one another by giving and taking referrals to help their users find the right parties to contact for a specific knowledge need.",
        "keywords": [
            "traditional approach",
            "specific knowledge need",
            "software agent",
            "personal social network",
            "right people",
            "multiagent referral system",
            "knowledge management",
            "communities resides",
            "right party",
            "informal social network",
            "agent-based approach",
            "software agents",
            "social network",
            "document management"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "North Carolina State University, Raleigh, NC"
            },
            {
                "name": "Munindar P. Singh",
                "org": "North Carolina State University, Raleigh, NC"
            }
        ],
        "venue": "CIKM",
        "year": 2002
    },
    "rVqbTrHM": {
        "id": "rVqbTrHM",
        "title": "An incentive mechanism for message relaying in unstructured peer-to-peer systems",
        "abstract": "Distributed message relaying is an important function of a peer-to-peer system to discover service providers. Existing search protocols in unstructured peer-to-peer systems create huge burden on communications, cause long response time, or result in unreliable performance. Moreover, with self-interested peers, these systems are vulnerable to the free-riding problem. In this paper we present an incentive mechanism that not only mitigates the free-riding problem, but also achieves good system efficiency in message relaying for peer discovery. In this mechanism promised rewards are passed along the message propagation process. A peer is rewarded if a service provider is found via a relaying path that includes this peer. The mechanism allows peers to rationally trade-off communication efficiency and reliability while maintaining information locality. We provide some analytic insights to the symmetric Nash equilibrium strategies of this game, and an approximate approach to calculate this equilibrium. Experiments show that this incentive mechanism brings a system utility generally higher than breadth-first search and random walks, based on both the estimated utility from our approximate equilibrium and the utility generated from learning in the incentive mechanism.",
        "keywords": [
            "incentive mechanism",
            "relaying path",
            "free-riding problem",
            "message propagation process",
            "reinforcement learning",
            "message relaying",
            "peer-to-peer system",
            "multi-level marketing models",
            "service provider",
            "estimated utility",
            "approximate equilibrium",
            "incentive mechanisms",
            "good system efficiency",
            "peer-to-peer systems",
            "unstructured peer-to-peer system",
            "free riding",
            "nash equilibrium",
            "random walk",
            "col",
            "breadth first search"
        ],
        "authors": [
            {
                "name": "Cuihong Li",
                "org": "School of Business, University of Connecticut, Storrs, CT 06269, United States"
            },
            {
                "name": "Bin Yu",
                "org": "Quantum Leap Innovations, 3 Innovation Way, Suite 100, Newark, DE 19711, United States"
            },
            {
                "name": "Katia P. Sycara",
                "org": "Robotics Institute, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, United States"
            }
        ],
        "venue": "Electronic Commerce Research and Applications",
        "year": 2009
    },
    "2RNPVXbr": {
        "id": "2RNPVXbr",
        "title": "Emergence and evolution of agent-based referral networks",
        "abstract": "",
        "keywords": [
            "agent-based referral network"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Munindar P. Singh",
                "org": ""
            }
        ],
        "venue": "Emergence and evolution of agent-based referral networks",
        "year": 2002
    },
    "ALANgIsn": {
        "id": "ALANgIsn",
        "title": "A lossless multi-secret sharing visual cryptography scheme",
        "abstract": "Considering the information loss during sharing multiple secrets, a definition of (n, n) lossless multisecret sharing visual cryptography is proposed. In addition, based on ring shares, an (n, n) multi-secret visual cryptography scheme, which shares secret images with no information loss, is designed. The experimental results show that in this scheme, not only multiple participants can share multiple secret images, but also secret images can be reconstructed perfectly.",
        "keywords": [
            "Lossless",
            "Multi-secret",
            "Perfect reconstruction",
            "Visual cryptography"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "Gang Shen",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "Fu Zheng-xin",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            }
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2012
    },
    "MVBtKpt2": {
        "id": "MVBtKpt2",
        "title": "LCD: Light-weight control model for data plane in software-defined wireless sensor networks: LCD: Light-weight control model for data plane in software-defined wireless sensor networks",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Meigen Huang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "transactions on emerging telecommunications technologies",
        "year": 2019
    },
    "hzWi53qx": {
        "id": "hzWi53qx",
        "title": "Improved Contrast for Threshold Random-grid-based Visual Cryptography.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Hu",
                "org": ""
            },
            {
                "name": "Gang Shen",
                "org": ""
            },
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "TIIS",
        "year": 2018
    },
    "hsdUeLzl": {
        "id": "hsdUeLzl",
        "title": "A new two-level QR code with visual cryptography scheme.",
        "abstract": "The Quick Response (QR) code is designed for information storage recognizable by machine vision. With the popularity of QR code applications, the security of QR codes becomes hot issues concerned by many scholars. In this paper, a novel QR code with two-level information storage is designed to protect private messages. In the meantime, the public level can be directly decoded by any standard QR reader. In contrast to other studies, the computational complexity of the proposed scheme is reduced by combining with the theory of visual cryptography scheme (VCS). In addition, an important characteristic of the QR code, error correction capability, is preserved in this paper, guaranteeing the robustness to QR code damage. Experimental results and analysis show that the proposed scheme is both feasible and reasonably secure, further enriching the application fields and outperforming the previous schemes significantly.",
        "keywords": [
            "QR code",
            " Two-level information storage",
            " VCS",
            " Low computational complexity",
            " High error correction"
        ],
        "authors": [
            {
                "name": "Yuqiao Cheng",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Gang Shen",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "Multimedia Tools Appl.",
        "year": 2018
    },
    "99wvvlXj": {
        "id": "99wvvlXj",
        "title": "A Modified Multi-Secret Sharing Visual Cryptography Scheme",
        "abstract": "A modified threshold visual cryptography scheme (k, l, n)-VCS is proposed, which is used to analyze the relationship between the pixel expansion and the range of the participantsÂ¿ number. Based on (k, l, n)-VCS, a more precise definition of multi-secret sharing visual cryptography scheme is given, and a new method is presented. Experimental results demonstrate that both pixel expansion and relative difference of this method are better than those of the previous ones.",
        "keywords": [
            "modified threshold visual cryptography scheme",
            "image coding",
            "cryptography",
            "natural language processing task",
            "pixel expansion",
            "modified multi-secret",
            "multisecret sharing visual cryptography scheme",
            "key technique",
            "information extraction",
            "visual cryptography scheme",
            "chinese ner",
            "entity recognition",
            "text summarization",
            "stacking",
            "visualization",
            "pixel",
            "security",
            "construction industry",
            "secret sharing"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Liguo Fang",
                "org": ""
            }
        ],
        "venue": "CIS (2)",
        "year": 2008
    },
    "oPbLtqcH": {
        "id": "oPbLtqcH",
        "title": "PUF-Assisted Group Key Distribution Scheme for Software-Defined Wireless Sensor Networks.",
        "abstract": "In this letter, a novel group key distribution scheme based on physical unclonable functions (PUFs) is proposed for software-defined wireless sensor networks. The PUF is difficult to be cloned and predicted, remarkably enhancing physical security performance of sensor nodes. In addition, under the centralized management of software-defined networking, PUF challenge is stored in the sensor nodes to...",
        "keywords": [
            "Wireless sensor networks",
            "Nickel",
            "Algorithm design and analysis",
            "Resists",
            "Authentication"
        ],
        "authors": [
            {
                "name": "Meigen Huang",
                "org": "Department of Computer Science, Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science, Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Sensen Li",
                "org": "Department of Computer Science, Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2018
    },
    "guzEpdzx": {
        "id": "guzEpdzx",
        "title": "SDN-Based Secure Localization in Heterogeneous WSN.",
        "abstract": "There is a big security risk in traditional distributed localization without protecting the location and identity privacy of anchor nodes. Thus, based on software-defined networking (SDN), we propose a security localization mechanism for heterogeneous wireless sensor networks (WSN). After obtaining the state of sensor nodes in data plane, SDN controller runs the complementary range-based and range-free positional algorithms in a centralized way. At the same time, the difference of transmission power of heterogeneous sensor nodes is taken into account. The security analysis and experimental results show that the mechanism can reduce the positioning error while ensuring the privacy of anchor nodes.",
        "keywords": "",
        "authors": [
            {
                "name": "Meigen Huang",
                "org": "Zhengzhou Information Science and Technology Institute"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute"
            }
        ],
        "venue": "ICICS",
        "year": 2017
    },
    "hwMHOZmw": {
        "id": "hwMHOZmw",
        "title": "On the generality of (k, n) XOR-based Visual Cryptography Scheme",
        "abstract": "The necessary condition of the optimal pixel expansion is given and proved in (k, n) XOR-based Visual Cryptography Scheme (XVCS). A new method is designed for constructing (k, n)-XVCS by use of basis matrices. The method is proved to be suitable for (k, n)-XVCS with 2<k>n. Based on the above results, the secret sharing and recovering algorithms are proposed. The experimental results show that the pixel expansion can be decreased efficiently. Furthermore, the secret images can be recovered perfectly.",
        "keywords": [
            "(k",
            " n) threshold structure",
            "Necessary condition of optimal pixel expansion",
            "Perfect recovery",
            "XOR-based Visual Cryptography (XVC)"
        ],
        "authors": [
            {
                "name": "Gang Shen",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "Fu Zheng-xin",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            }
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2013
    },
    "hFhEUJss": {
        "id": "hFhEUJss",
        "title": "On the Generality of (k, n) XOR-based Visual Cryptography Scheme: On the Generality of (k, n) XOR-based Visual Cryptography Scheme",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "zhengxin fu",
                "org": ""
            },
            {
                "name": "gang shen",
                "org": ""
            }
        ],
        "venue": "Journal of Electronics Information & Technology",
        "year": 2014
    },
    "99FWxbSe": {
        "id": "99FWxbSe",
        "title": "Ideal Secure Multi-Secret Visual Cryptography Scheme with Ring Shares.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "T. Data Hiding and Multimedia Security",
        "year": 2014
    },
    "XVHEQRfb": {
        "id": "XVHEQRfb",
        "title": "A two-level QR code scheme based on polynomial secret sharing",
        "abstract": "Quick Response codes (QR codes) are common two-dimensional machine readable codes used extensively in all walks of life due to their high reading speeds, high data density, and strong error correction capabilities. However, public encoding using QR codes poses a threat to information security. In this paper, we introduce a Two-Level QR code that protects private data by using the recognition patterns of QR codes and by use of polynomial secret sharing algorithms. On a public level, QR codes are decodable by any standard QR reader. For secure use, QR codes simultaneously store private information, allowing transmission of secret information via an open channel. Experimental results and analysis demonstrate that this proposed approach is both feasible and reasonable. It reduces the probability of attracting the attention of potential attackers. The secret image format can accommodate either binary or grayscale. In addition, the data capacity of the secret payload of this approach is much higher than other methods.",
        "keywords": [
            "Two-level QR code",
            " Polynomial secret sharing algorithm",
            " Secret payload"
        ],
        "authors": [
            {
                "name": "Sijia Liu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "Multimedia Tools and Applications",
        "year": 2019
    },
    "Dd4JLjD4": {
        "id": "Dd4JLjD4",
        "title": "Improved Visual Secret Sharing Scheme for QR Code Applications.",
        "abstract": "Quick response (QR) codes have been widely used in applications, such as data storage and high-speed machine reading. Anyone can gain access to the information stored in QR codes; therefore, they are unsuitable for encoding secret information without the addition of cryptography or other protection. In this paper, we propose a visual secret sharing scheme to encode a secret QR code into several sh...",
        "keywords": [
            "Cryptography",
            "Error correction codes",
            "Visualization",
            "Information science",
            "Error correction",
            "Encoding"
        ],
        "authors": [
            {
                "name": "Yuqiao Cheng",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "IEEE Transactions on Information Forensics and Security",
        "year": 2018
    },
    "rSnDWhNA": {
        "id": "rSnDWhNA",
        "title": "Perfect contrast XOR-based visual cryptography schemes via linear algebra.",
        "abstract": "XOR-based visual cryptography scheme (XVCS) was proposed to solve the poor visual quality problem without darkening the background in the reconstructed secret image. However, investigations on XVCS are not sufficient. In this paper, we focus on the traditional model of VCS for general access structures and exploit some extended capabilities for XVCS. Our main contributions are: (1) we put forward constructions of perfect contrast XVCS using the linear algebraic technique without any assumptions such as participants may carry multiple shares or prior information about the shares are to be submitted during the secret reconstruction phase; (2) for some restricted access structures, we achieve perfect contrast and perfect pixel expansion, namely both 1, which is impossible for any OR-based visual cryptography scheme (OVCS); (3) for general access structures, we achieve perfect contrast with smaller pixel expansion compared with many of the results in the literature; (4) Theoretical analysis on the proposed constructions are provided, as well as extensive experimental results and comparisons for demonstrating the effectiveness and advantages of our constructions.",
        "keywords": [
            "Visual cryptography",
            "XOR",
            "General access structure",
            "Linear algebra",
            "Perfect contrast",
            "15A03",
            "94A60"
        ],
        "authors": [
            {
                "name": "Gang Shen",
                "org": "Zhengzhou Information Science and Technology Institute"
            },
            {
                "name": "Feng Liu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute"
            }
        ],
        "venue": "Des. Codes Cryptography",
        "year": 2017
    },
    "V3MA7uxm": {
        "id": "V3MA7uxm",
        "title": "Co-cheating prevention visual cryptography scheme based on random numbers",
        "abstract": "A novel co-cheating prevention visual cryptography scheme (VCS) based on random numbers is proposed in this paper. Shares are created by random numbers, and the (n, n) secret sharing algorithm is implemented through special algorithms in the scheme. Furthermore, the scheme is expanded to general access structure using cumulative array. Theoretical proof and experimental results indicate that the proposed scheme not only prevents co-cheating well, but also reduces storing costs, as there is no pixel expansion. Moreover, it alleviates participant's extra burden, since verification shares are unnecessary. © 2013 by CESER Publications.",
        "keywords": [
            "co-cheating",
            "cumulative array",
            "random numbers",
            "visual cryptography"
        ],
        "authors": [
            {
                "name": "LiGuo Fang",
                "org": "Zhengzhou Information Science Technology Institute(Information Science and Technology Institute),Zhengzhou,China"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science Technology Institute(Information Science and Technology Institute),Zhengzhou,China"
            },
            {
                "name": "Yu Bin",
                "org": "Zhengzhou Information Science Technology Institute(Information Science and Technology Institute),Zhengzhou,China"
            },
            {
                "name": "Jinyuan Lu",
                "org": "Zhengzhou Information Science Technology Institute(Information Science and Technology Institute),Zhengzhou,China"
            }
        ],
        "venue": "International Journal of Applied Mathematics and Statistics",
        "year": 2013
    },
    "xfriEJh7": {
        "id": "xfriEJh7",
        "title": "Performance analysis and reliability improvement of bluetooth broadcast scheme",
        "abstract": "In bluetooth wireless system, data is transmitted between master and slaves by unicast or broadcast. With broadcasting, data can be transmitted to some or all nodes in a more efficient way in terms of consumed network capacity than sending the same packet to all nodes one at a time using unicast strategy. However, because the master transmits to all the slaves simultaneously, the acknowledgement mechanism does not work, and the reliable delivery of packet may not be guaranteed. In this paper, we study the performance of current bluetooth broadcasting scheme and obtain a result which can be used to determine the optimal packet type and retransmission count that can provide the highest effective throughput values for some practical BER ranges. To improve the reliability of broadcast, we propose a reliable packet delivery policy called extended-ARQ (Automatic Repeat Request), which is an extension of ARQ in the one-to-multi communication system. Our simulation results show that the extended-ARQ policy guarantees the reliable packet delivery and maximizes the effective throughput by preventing a broadcast packet from being retransmitted unnecessarily.",
        "keywords": [
            "ber",
            "bluetooth broadcast",
            "extended-arq",
            "reliability",
            "throughput",
            "bluetooth",
            "automatic repeat request",
            "broadcasting",
            "communication system"
        ],
        "authors": [
            {
                "name": "Liang Junxue",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "Li Yingchuan",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "Yu Bin",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            }
        ],
        "venue": "SPCA 2006: 2006 First International Symposium on Pervasive Computing and Applications, Proceedings",
        "year": 2007
    },
    "UWaAOQHO": {
        "id": "UWaAOQHO",
        "title": "A new two-level information protection scheme based on visual cryptography and QR code with multiple decryptions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Yuqiao Cheng",
                "org": ""
            },
            {
                "name": "Sijia Liu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Measurement",
        "year": 2019
    },
    "uFI3GTlT": {
        "id": "uFI3GTlT",
        "title": "Visual Cryptography Scheme With Meaningful Shares Based on QR Codes.",
        "abstract": "In the past few years, visual cryptography scheme (VCS) has aroused much research attention and developed rapidly because of its simple decryption. However, meaningless shares remain a continuing challenge of VCS to its practical applications. In this paper, we propose a (   $k$   ,    $n$   )-VCS combining with QR codes. To enlarge the allowable maximum size of secret image, a probabilistic sharing model is utilized. Based on it, a secret sharing method is presented with high relative difference. Furthermore, we embed the initial shares into cover QR codes by using encoding redundancy. After that, each share is meaningful and can be read by any standard QR code reader. Different from previous work, error correction capacities of the covers are perfectly preserved. We also highlight that our scheme can be used to authenticate the security of QR codes from some uncertain sources. Finally, experimental results and comparisons are provided to show the feasibility and advantages of the proposed scheme.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Yuqiao Cheng",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "IEEE Access",
        "year": 2018
    },
    "B1n5bzmY": {
        "id": "B1n5bzmY",
        "title": "The Access-based Multi-secret Visual Cryptography with Compression Algorithm: The Access-based Multi-secret Visual Cryptography with Compression Algorithm",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhengxin fu",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "liguo fang",
                "org": ""
            }
        ],
        "venue": "Journal of Electronics Information & Technology",
        "year": 2014
    },
    "OQ5YdVlP": {
        "id": "OQ5YdVlP",
        "title": "Visual cryptograms of random grids via linear algebra.",
        "abstract": "Two visual models of image secret sharing have been studied: visual cryptography schemes (VCS), introduced by Naor and Shamir, and visual cryptograms of random grids (VCRG), introduced by Kafri and Keren. VCRG has gained much attention in academia than before to avoid the pixel expansion of VCS. Although there is a strict relation between VCRG and VCS, VCRG can still be improved to achieve a better result. In this paper, based on new insight into linear algebraic technique to construct VCS, where we are able to construct VCS by solving a linear system of more equations at a time, we put forward a new construction of VCRG for general access structures. The effectiveness and advantage of the proposed construction are formally analyzed and experimentally demonstrated. With theoretical and practical interests, our construction exposes new possibilities to the researches of visual models of image secret sharing.",
        "keywords": [
            "Image secret sharing",
            " Visual cryptography",
            " Random grid",
            " Linear algebra",
            " General access structure"
        ],
        "authors": [
            {
                "name": "Gang Shen",
                "org": ""
            },
            {
                "name": "Feng Liu",
                "org": ""
            },
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Multimedia Tools Appl.",
        "year": 2018
    },
    "xivVYz2H": {
        "id": "xivVYz2H",
        "title": "LCD: Light-weight control model for data plane in software-defined wireless sensor networks.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Meigen Huang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Trans. Emerging Telecommunications Technologies",
        "year": 2019
    },
    "RFIWQfyy": {
        "id": "RFIWQfyy",
        "title": "Towards General Software-Defined Wireless Sensor Networks",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Meigen Huang",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, 450001, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, 450001, China"
            }
        ],
        "venue": "ieee international conference computer and communications",
        "year": 2018
    },
    "5RwOAvBU": {
        "id": "5RwOAvBU",
        "title": "General Construction for Extended Visual Cryptography Scheme Using QR Codes.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuqiao Cheng",
                "org": "Science and Technology on Information Assurance Laboratory, Beijing, China"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Gang Shen",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "IJDCF",
        "year": 2019
    },
    "AmhqpJWD": {
        "id": "AmhqpJWD",
        "title": "A Co-cheating Prevention Visual Cryptography Scheme",
        "abstract": "Participants colluding is an important issue of cheater detectable visual cryptography schemes. Based on a trusty third party, a co-cheating prevention visual cryptography scheme (CCPVCS) is proposed in this paper. Checking efficiency is improved by verifying the truth of several shares simultaneously, with designed special verification shares. Since the scheme idea is different from previous ones, the pixel expansion is small and the recovered secret image is good for viewing.",
        "keywords": [
            "co-cheating prevention visual cryptography",
            "trusty third party",
            "checking efficiency",
            "image coding",
            "important issue",
            "verification shares",
            "co-cheating prevention",
            "cryptography",
            "co-cheating prevention visual cryptography scheme",
            "secret image",
            "special verification share",
            "pixel expansion",
            "co-cheating",
            "participants colluding",
            "cheater detectable visual cryptography",
            "scheme idea",
            "visual cryptography scheme",
            "visual cryptography",
            "pixel",
            "visualization",
            "image reconstruction",
            "stacking",
            "information science",
            "construction industry",
            "color",
            "pattern recognition"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Jin-Yuan Lu",
                "org": ""
            },
            {
                "name": "Li-Guo Fang",
                "org": ""
            }
        ],
        "venue": "ICIC), 2010 Third International Conference",
        "year": 2010
    },
    "PaWdwTPT": {
        "id": "PaWdwTPT",
        "title": "Rich QR Codes With Three-Layer Information Using Hamming Code.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Sijia Liu",
                "org": ""
            },
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "IEEE Access",
        "year": 2019
    },
    "q1uFnlpt": {
        "id": "q1uFnlpt",
        "title": "Anti-cheating visual cryptography scheme based on probability: Anti-cheating visual cryptography scheme based on probability",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Bin YU",
                "org": ""
            },
            {
                "name": "Yi-wei WANG",
                "org": ""
            },
            {
                "name": "Li-guo FANG",
                "org": ""
            }
        ],
        "venue": "Journal of Computer Applications",
        "year": 2009
    },
    "4VAidNF3": {
        "id": "4VAidNF3",
        "title": "Perfect recovery of XOR-based visual cryptography scheme.",
        "abstract": "Visual cryptography is an interesting secret sharing scheme, in which participants can observe the secret image by stacking their shares. However, the size expansion and distorted visual effect are two disadvantages of visual cryptography. In this paper, we focus on how to realize the perfect recovery by XOR-ing shares directly. First, we propose the definition of ideal access structure, which is the key point of perfect recovery of XOR-based visual cryptography scheme. The characteristics of ideal access structure are analyzed, and the construction algorithm of shares under ideal access structure is designed. Based on the ideal access structure, a new algorithm is proposed for dividing the general access structure into several ideal access structures, and the secret sharing and recovering algorithms for general access structure are presented. Furthermore, our method can also be utilized in color visual cryptography and multi-secret visual cryptography. The security and perfect recovery of our method have been proved theoretically. Compared with the previous schemes, the proposed scheme realizes the perfect recovery of secret image by XOR-ing shares directly, and the sizes of shares can be decreased efficiently compared with the previous schemes.",
        "keywords": [
            "Visual cryptography",
            " XOR Operation",
            " Ideal access structure",
            " Perfect recovery",
            " General access structure",
            " Color image",
            " Multiple secret images"
        ],
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": "Information Engineering University"
            },
            {
                "name": "Yuqiao Cheng",
                "org": "Information Engineering University"
            },
            {
                "name": "Bin Yu",
                "org": "Information Engineering University"
            }
        ],
        "venue": "Multimedia Tools Appl.",
        "year": 2019
    },
    "znL1tXpT": {
        "id": "znL1tXpT",
        "title": "The Multi-secret Visual Cryptography Based on Ring Shares",
        "abstract": "Based on the correlative matrices,which are designed by dividing secret images and shares into vertical areas,a new multi-secret visual cryptography scheme is presented in this paper. Compared to the previous ones,the proposed scheme makes the number of secret images not restricted and has obviously improved the pixel expansion and the relative difference.",
        "keywords": [
            "Multiple secrets",
            "Correlative matrices",
            "Visual cryptography",
            "Ring shares"
        ],
        "authors": [
            {
                "name": "Zheng-xin Fu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Li-guo Fang",
                "org": ""
            }
        ],
        "venue": "Journal of Electronics Information & Technology",
        "year": 2010
    },
    "urkprMUp": {
        "id": "urkprMUp",
        "title": "Improved schemes for visual secret sharing based on random grids",
        "abstract": "Random grid (RG) is an alternative approach to realize a visual secret sharing (VSS) scheme. RG-based VSS has merits such as no pixel expansion and no tailor-made matrix requirement. Recently, many investigations on RG-based VSS are made. However, they need further improvements. In this paper, we obtain some improvements on RG-based VSS. Actually, two improved schemes are proposed, namely RG-based VSS for general access structure (GAS) with improved contrast and extended RG-based VSS with improved access structure. The first scheme can achieve better contrast than previous schemes. The second scheme reduces the chance of suspicion on secret image encryption by generating meaningful shares instead of noise-like shares in the first scheme, and improves the access structure from (k, k) to GAS while maintaining the property that the contrast of the recovered image is traded with that of share images by setting a certain parameter from small to large. Finally, theoretical analyses and experimental results are provided to demonstrate the effectiveness and advantages of the proposed schemes.",
        "keywords": [
            "Secret image sharing",
            " Visual secret sharing",
            " Visual cryptography",
            " Random grid",
            " General access structure",
            " Meaningful share"
        ],
        "authors": [
            {
                "name": "Hao Hu",
                "org": "Zhengzhou Information Science and Technology Institute"
            },
            {
                "name": "Gang Shen",
                "org": "Zhengzhou Information Science and Technology Institute"
            },
            {
                "name": "Yuling Liu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute"
            }
        ],
        "venue": "Multimedia Tools and Applications",
        "year": 2018
    },
    "Bzt0AA5n": {
        "id": "Bzt0AA5n",
        "title": "Improved Extended Polynomial-Based Secret Image Sharing Scheme Using QR Code.",
        "abstract": "Secret image sharing technology is an effective approach to encode the secret image into several shares, and the original image can be recovered by the remaining shares even some shares are lost. As a typical two-dimensional machine reada-ble code, QR code is widely used in human life due to its fast reading speed, high data density and strong error correction capability. Combined with the characteristics of QR code and secret image sharing, an  secret image sharing scheme was proposed based on QR code, where extended means that the generated shares were visually similar to the QR code. The main idea is to control the parametersu0027 selec-tion of polynomial using the binary QR codes. Meanwhile, the average gray difference of the shares was defined as α to measure the similarity between QR-like shares and the origi-nal carrier QR codes. Based on α, a secret sharing algorithm was designed to generate QR-like shares. At last, upper and lower limits of α are introduced through experimental analy-sis, and the relationship between the error correction level of carrier QR code and the lower limit of α.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Sijia Liu",
                "org": ""
            },
            {
                "name": "Kun Xia",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "CIS",
        "year": 2018
    },
    "up6UCPlg": {
        "id": "up6UCPlg",
        "title": "Research on Rotation Visual Cryptography Scheme",
        "abstract": "Based on correlative matrices set and random permutation, a new construction of rotation visual cryptography scheme (RVCS) has been presented, which can be used to encode four secret images into two shares. Experimental results demonstrate that four secrets can be recovered clearly by stacking two shares with different angles and the shapes of the reconstructed images do not have distortions.",
        "keywords": [
            "image coding",
            "correlative matrix set",
            "cryptography",
            "secret image",
            "new construction",
            "correlative matrix",
            "matrix algebra",
            "different angle",
            "rotation",
            "image reconstruction",
            "reconstructed image",
            "random permutation",
            "rotation visual cryptography scheme",
            "images shape",
            "visual cryptography",
            "construction industry",
            "electronic commerce",
            "security",
            "color",
            "visualization",
            "image resolution",
            "stacking",
            "pixel",
            "displays",
            "shape"
        ],
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Ternopil",
        "year": 2009
    },
    "hGhf4IYT": {
        "id": "hGhf4IYT",
        "title": "Lossless sharing visual cryptography",
        "abstract": "According to the information loss during the secret image sharing process, the lossless sharing visual cryptography was proposed. The optimizations of two parameters were simplified into one parameter. The matrices translation algorithm and the integer programming model were designed. Furthermore, the pixel expansion optimization algorithm was realized. The experimental results show that the algorithm achieves the optimal pixel expansion under lossless sharing, and can be used in general access structure.",
        "keywords": [
            "Lossless sharing",
            "Optimization algorithm",
            "Pixel expansion",
            "Visual cryptography"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            },
            {
                "name": "FU Zheng-xin",
                "org": "Information Engineering University China(Information Engineering University,PLA Information Engineering University),Zhengzhou,China"
            }
        ],
        "venue": "Tongxin Xuebao/Journal on Communications",
        "year": 2013
    },
    "Qo547nAx": {
        "id": "Qo547nAx",
        "title": "New insight into linear algebraic technique to construct visual cryptography scheme for general access structure.",
        "abstract": "The most essential advantage of applying linear algebra to construct visual cryptography scheme (VCS) lies in that it only requires solving linear equations in the construction of initial basis matrices, which are the basis matrices before removing the common columns. In this paper, we give some new insight into linear algebraic technique to construct VCS, where we can take more equations simultaneously. Then based on this knowledge, we propose a construction of VCS for general access structure. The construction is efficient in the sense that it gets the smallest initial pixel expansion compared with some well-known constructions. At the same time, by using the technique of deleting common columns from the initial basis matrices, the proposed construction achieves the optimal pixel expansions in most cases according to our experimental results. However, finding exact number of common columns in the initial basis matrices is a challenging issue. Then we deal with this issue and find out that the exact number of common columns is n ź 2 for (2, n) threshold access structures. Finally, we provide some future research directions in the algebraic aspect of VCS.",
        "keywords": [
            "Visual cryptography",
            " Basis matrices",
            " Linear algebra",
            " More equations",
            " Common columns"
        ],
        "authors": [
            {
                "name": "Gang Shen",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Feng Liu",
                "org": "State Key Laboratory of Information Security, Institute of Information Engineering, Chinese Academy of Sciences, Beijing, China and School of Cyber Security, University of Chinese Academy of Scien ..."
            },
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "Multimedia Tools Appl.",
        "year": 2017
    },
    "e9AGhkUt": {
        "id": "e9AGhkUt",
        "title": "Rich QR code with three-layer information using visual secret sharing scheme",
        "abstract": "Owing to efficient machine recognition, QR codes have been widely used in many aspects such as information management, electronic identity and mobile payment. Any QR code reader has access to the message contained in a QR code; therefore, in formation security becomes a major challenge to QR codes for private use. Moreover, human vision is hard to distinguish a QR code from others because its appearance looks randomly. In this paper, we propose a visual secret sharing scheme to achieve a rich QR code with three-layer information storage. In the three layers, the first one and the second one are respectively recognizable by human vision and QR code readers, while the third layer is designed for storing private data. Additionally, we also highlight the low computational complexity of secret extraction from the rich QR code.",
        "keywords": [
            "QR code",
            " Visual secret sharing scheme",
            " Three-layer information storage",
            " Low computational complexity"
        ],
        "authors": [
            {
                "name": "Zhengxin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Yuqiao Cheng",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, Zhengzhou, China"
            }
        ],
        "venue": "Multimedia Tools and Applications",
        "year": 2019
    },
    "H0VKODv9": {
        "id": "H0VKODv9",
        "title": "On the security of multi-secret visual cryptography scheme with ring shares",
        "abstract": "With visual cryptography in mind, the security property of a new scheme is always one of main concerns. However, the ideal security is not taken into account in some visual cryptography schemes sharing multiple secrets. In this paper, the security of a multi-secret visual cryptography scheme proposed by Feng et al. is analyzed. We show that the security of their scheme is not ideal. Precisely, it is insecure since some information of the secret images can be inferred by block attacking the second share alone. The main weak design is proved and shown by means of giving theoretical analysis and conducting some counter experiments.",
        "keywords": [
            "multiple secret",
            "main concern",
            "visual cryptography scheme",
            "counter experiment",
            "main weak design",
            "visual cryptography",
            "multi-secret visual cryptography scheme",
            "ring share",
            "security property",
            "ideal security",
            "new scheme",
            "security"
        ],
        "authors": [
            {
                "name": "Zheng-Xin Fu",
                "org": "Zhengzhou Information Science and Technology Institute, P.R. China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Information Science and Technology Institute, P.R. China"
            }
        ],
        "venue": "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
        "year": 2013
    },
    "7NHE3KXz": {
        "id": "7NHE3KXz",
        "title": "Apical pedicle subtraction osteotomy in the treatment of severe rigid kyphoscoliosis:a preliminary report]",
        "abstract": "To evaluate the safety and efficacy of apical pedicle subtraction osteotomy (PSO) in the treatment of severe kyphoscoliosis.The radiographic films of the 12 severe kyphoscoliosis patients treated with apical pedicle subtraction osteotomy were retrospectively reviewed, and the Cobb angles of the scoliosis and kyphosis and coronal trunk balance were measured and analyzed. Medical records and operation charts were reviewed to record any peri-operative complications.Twelve patients were included in this study, 4 males and 8 females, with an average age of 20.1 years old. Of the 12 patients, 2 were adult kyphoscoliosis and 10 were congenital kyphoscoliosis. The mean follow-up time was 9.2 months. The mean fusion levels were 12 segments and the mean operation time was 5.0 hours. The mean estimated blood loss during operation was 1517 ml and the mean autotransfusion and allotransfusion were 780 ml and 1109 ml, respectively. The mean preoperative and postoperative coronal Cobb angle of the main curve was 100.9 degrees and 48.8 degrees , with an average correction rate of 51.8% (P = 0.000). The mean preoperative and postoperative sagittal Cobb angle of the kyphosis was 81.7 degrees and 42.2 degrees , with an average correction rate of 49.8% (P = 0.000). At final follow-up, the mean Cobb angles of the scoliosis and kyphosis were 50.7 degrees and 46.0 degrees , respectively, and no obvious correction loss was found (P = 0.763, P = 0.698). The mean coronal trunk balance before, after surgery and at final follow-up was 16.3 mm, 14.7 mm, and 12.0 mm, respectively. Only 1 patient had trunk shift greater than 20 mm at final follow-up. After operation, two patients suffered from transient numbness and weakness of the unilateral lower extremity with complete recovery in one week. No spinal cord injury occurred.Apical pedicle subtraction osteotomy can be easily performed in the treatment of severe rigid kyphoscoliosis with satisfactory correction results and few neurologic complications.",
        "keywords": [
            "abnormalitis",
            "osteotomy",
            "scoliosis"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-guo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Gui-xing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yi-peng Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Hong Zhao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Shu-gang Li",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yu Zhao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2009
    },
    "ETrdtFZu": {
        "id": "ETrdtFZu",
        "title": "Posterior selective thoracic fusion in adolescent idiopathic scoliosis.",
        "abstract": "To define the criteria of posterior selective thoracic fusion in patients with adolescent idiopathic scoliosis.By reviewing the medical records and roentgenograms of 17 patients with adolescent idiopathic scoliosis who underwent posterior selective thoracic fusion, the curve type, Cobb angle, apical vertebral rotation and translation, trunk shift, and thoracolumbar kyphosis were measured and analyzed.There were 17 King type II patients (PUMC type: IIb, 13, IIc3 4). The coronal Cobb angle of thoracic curve before and after operation were 56.9 degrees and 21.6 degrees respectively, the mean correction rate was 60.1%. The coronal Cobb angle of lumbar curve before and after operation were 34.8 degrees and 12.1 degrees respectively, and the mean spontaneous correction rate was 64.8%. At final follow-up, the coronal Cobb angle of thoracic and lumbar curve were 23.5 degrees and 15.2 degrees respectively, there were no significant changes in the coronal Cobb angle, apical vertebral translation and rotation compared with that after operation. One patient had 12 degrees of thoracolumbar kyphosis after operation, no progression was noted at final follow-up. There was no trunk decompensation or deterioration of the lumbar curve. In this group, 3.9 levels were saved compared with fusing both the thoracic and lumbar curves.Posterior selective thoracic fusion can be safely and effectively performed in King type II patients with a moderate and flexible lumbar curve, which can save more mobile segments and at the same time can maintain a good coronal and sagittal balance.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "selective thoracic fusion"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-guo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Gui-xing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yi-peng Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Xi-sheng Weng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences",
        "year": 2004
    },
    "GcEvh7XL": {
        "id": "GcEvh7XL",
        "title": "Comparison of reliability between the PUMC and Lenke classification systems for classifying adolescent idiopathic scoliosis.",
        "abstract": "Comparison of 2 radiographic scoliosis classification systems by multiple surgeons.Compare the reliability of Peking Union Medical College (PUMC) and Lenke scoliosis classification systems and analyze their differences.The PUMC classification is a newly reported system based on radiographic measurements with recent popularity, while the Lenke classification is widely accepted worldwide in surgical design. Both these classification systems have their own individual characteristics, hence it is necessary to compare their reliability.Five scoliosis surgeons independently evaluated and classified presurgical radiographs of 62 adolescent idiopathic scoliosis patients based on the PUMC and Lenke classification systems on 2 separate occasions. Radiographs were cleaned before each evaluation. Inter- and intraobserver reliabilities were quantified using Kappa statistics. Data were compared using chi2 analysis.The PUMC classification's inter- and intraobserver percentage of agreement averaged to 91.0% (Kappa coefficient 0.896) and 90.2% (Kappa coefficient 0.892), respectively. While those of the Lenke curve type classification were 86.5% (Kappa coefficient 0.808) and 87.4% (Kappa coefficient 0.826). The PUMC classification from 10 individual measurements had 17 cases (27.4%) of disagreements, while in the Lenke curve type classification, 24 cases (38.7%) had disagreements. PUMC classification normally has discrepancies between type IIb, IIc, and IId, while Lenke classification has discrepancies in curve types 1 and 2. Out of 17 inconsistent PUMC curve type cases, 7 did not affect surgical fusion levels, while in the Lenke's only 2 out of 24 cases with discrepancies did not affect fusion range selection, with an obvious statistical difference.The reliability of both PUMC classification and Lenke curve type classification were categorized as good-to-excellent. PUMC classification is relatively simple, with less confusion among inter- and intraobservers, with corresponding surgical fusion guidance and planning. The mismatch of curve classification had less influence on PUMC's fusion range selection than Lenke's.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "curve classification",
            "lenke",
            "pumc",
            "classification system"
        ],
        "authors": [
            {
                "name": "Guixing Qiu",
                "org": ""
            },
            {
                "name": "Qiyi Li",
                "org": ""
            },
            {
                "name": "Yipeng Wang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Jun Qian",
                "org": ""
            },
            {
                "name": "Keyi Yu",
                "org": ""
            },
            {
                "name": "Chia I Lee",
                "org": ""
            },
            {
                "name": "Jianguo Zhang",
                "org": ""
            },
            {
                "name": "Jianxiong Shen",
                "org": ""
            },
            {
                "name": "Yu Zhao",
                "org": ""
            },
            {
                "name": "Xisheng Weng",
                "org": ""
            },
            {
                "name": "Ting Wang",
                "org": ""
            },
            {
                "name": "Darwesh M K Aladin",
                "org": ""
            },
            {
                "name": "Weijia William Lu",
                "org": ""
            }
        ],
        "venue": "Spine",
        "year": 2008
    },
    "yODGX3No": {
        "id": "yODGX3No",
        "title": "Comparison of correction outcomes after anterior or posterior approach with lowest and vertebra instrumentation in adolescent idiopathic thoracolumbar/lumbar scoliosis]",
        "abstract": "To evaluate the different influences upon the correction outcomes after anterior or posterior correction and fusion with lowest end vertebra instrumentation in adolescent idiopathic thoracolumbar/lumbar scoliosis.By reviewing the medical records and roentgenograms of adolescent idiopathic thoracolumbar/lumbar scoliosis patients undergoing anterior (single rod-Group A) or posterior (all pedicle screws-Group B) correction and instrumentation, the parameters of Cobb angle of the curve, correction rate and disc angle were measured and analyzed.There were 18 patients in Group A and 21 patients in Group B. The curve included 5.0 vertebrae and 5.5 vertebrae (P = 0.134) respectively, and the fusion levels were 4.7 vertebrae and 5.4 vertebrae (P = 0.008) respectively. The mean pre-operative and post-operative coronal Cobb angles of the main curve in Groups A and B were 49.2 degrees and 10.3 degrees , 42.2 degrees and 5.0 degrees with an average correction rate of 78.5% and 87.8% respectively. The Cobb angles were all significantly corrected (all P = 0.000), and group B had a better correction result (P = 0.020). At final follow-up, the coronal Cobb angles in the two groups were 21.7 degrees and 7.7 degrees with an average correction loss of 8.3 degrees and 2.7 degrees (P = 0.001) respectively. The disc angles at pre-operation, post-operation and final follow-up were 3.1 degrees , 5.6 degrees and 7.3 degrees in Group A and 2.3 degrees , 4.2 degrees and 4.4 degrees in Group B respectively. The disc angle at post-operation was larger than that at pre-operation and the difference was significant in Group A (P = 0.049) while not in Group B (P = 0.050). The difference of post-operative disc angle between two groups was not significant (P = 0.231). At final follow-up, the disc angle was a little larger than that of post-operation without a significant difference (P = 0.112, P = 0.855) while Group A had a larger disc angle (P = 0.026). At final follow-up, the occurrence of proximal junctional kyphosis between Groups A and B was not significant (P = 0.235).For adolescent idiopathic thoracolumbar/lumbar scoliosis, in comparison with the anterior approach, the posterior approach using all pedicle screws can achieve a better correction outcome, a less correction loss of coronal Cobb angle and a better disc angle with a longer fusion range.",
        "keywords": [
            "orthopedics",
            "scoliosis",
            "spinal diseases"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yi-peng Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Gui-xing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-guo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-xiong Shen",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Qi-yi Li",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Xin-yu Yang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Li-juan Zhao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2009
    },
    "lDlcrZal": {
        "id": "lDlcrZal",
        "title": "Spinal factors affecting pulmonary function in patients with scoliosis",
        "abstract": "Objective: To investigate pulmonary function impairment and the spinal factors that may determine pulmonary function in patients with scoliosis. Methods: Seventy-eight patients with idiopathic scoliosis or congenital scoliosis and 78 age- and gender-matched healthy subjects were enrolled in this study. The radiographic parameters of spinal deformity were obtained from patients with scoliosis. Both two groups received pulmonary function tests. Results: Patients with scoliosis demonstrated a restrictive pattern of pulmonary function impairment with a proportional decrease in both forced expiratory volume in one second and forced vital capacity. Total lung capacity and functional residual capacity were reduced. Carbon monoxide diffusion capacity was decreased, while diffusion coefficient remained normal or slightly higher. Airway resistance and conductance were not affected. In addition, airway resistance and residual volume were found abnormal in patients with congenital scoliosis. Multiple linear regression analysis showed that three spinal factors including involved thoracic vertebrae, vertical height from C7 to S1, and Cobb angle were independently responsible for 40%-51% of total variances of forced vital capacity, forced expiratory volume in one second, total lung capacity, and functional residual capacity. Conclusions: Patients with scoliosis have restrictive ventilation defects. More thoracic vertebrae involvement, lower vertical height, and larger Cobb angle are associated with severer impairment of lung volume.",
        "keywords": [
            "Congenital scoliosis",
            "Idiopathic scoliosis",
            "Pulmonary function",
            "Spinal deformity"
        ],
        "authors": [
            {
                "name": "Ran Hao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Wu Zhi-hong",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Han Jiang-na",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Meng Shu-zhen",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Zhu Yuan-Jue",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Wang Yi-peng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Qiu Gui-xing",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2011
    },
    "My4dzCwn": {
        "id": "My4dzCwn",
        "title": "The efficacy and complications of posterior hemivertebra resection.",
        "abstract": "There have been several reports on hemivertebra resection via a posterior-only procedure. However, the number of reported cases is small, and various types of instrumentation have been used. In our study, we retrospectively investigated 56 consecutive cases of congenital scoliosis that were treated by posterior hemivertebra resection with transpedicular instrumentation. Radiographs were reviewed to determine the type and location of the hemivertebra, the coronal curve magnitude and the sagittal alignment pre-operatively, post-operatively and at the latest follow-up. Radiographs were also used to assess implant failure and inter-body fusion. Surgical reports and patient charts were reviewed to record any peri-operative complications. Fifty-eight posterior hemivertebrae resections from 56 patients aged 1.5-17 years with fully segmented non-incarcerated hemivertebra were evaluated. The average age at surgery was 9.9 years (1.5-17 years). The average follow-up was 32.9 months (24-58 months). The mean fusion level was 5.0 segments (2-11 segments). There was a mean improvement of 72.9% in the segmental scoliosis, from 42.4° before surgery to 12.3° at the time of the latest follow-up, and there was a mean improvement of 70% in segmental kyphosis from 42.0° to 14.5° over the same time period. The thoracic kyphosis (T5-T12) averaged 10.8° before surgery and 23.9° at the latest follow-up. The lumbar lordosis (L1-S1) averaged -52.8° before surgery and -51.6° at the latest follow-up. Two cases with neurological claudications had complete recovery immediately after the surgery. There was one case of delayed wound healing, two fractures of the pedicle at the instrumented level, two rod breakages and one proximal junction kyphosis that required revision. There were no neurological complications. Radiolucent gaps were found in the residual space after resection on the lateral view in five cases, without any sign of implant failure or correction loss. Our results show that one-stage posterior hemivertebra resection with transpedicular instrumentation can achieve excellent correction, 360° decompression and short fusion without neurological complications. Pedicle cutting still remains a challenge in younger children when using bisegmental instrumentation. In addition, the radiolucent gaps in the residual space require further investigation.",
        "keywords": [
            "congenital scoliosis hemivertebra resection posterior surgery"
        ],
        "authors": [
            {
                "name": "Jianguo Zhang",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730 People’s Republic of China"
            },
            {
                "name": "Wang Shengru",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730 People’s Republic of China"
            },
            {
                "name": "Guixing Qiu",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730 People’s Republic of China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730 People’s Republic of China"
            },
            {
                "name": "Wang Yipeng",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730 People’s Republic of China"
            },
            {
                "name": "Keith D K Luk",
                "org": "Department of Orthopedics and Traumatology, Queen Mary Hospital, University of Hong Kong, Hong Kong, People’s Republic of China"
            }
        ],
        "venue": "European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society",
        "year": 2011
    },
    "1B5A2kBD": {
        "id": "1B5A2kBD",
        "title": "Posterior hemivertebra resection with bisegmental fusion for congenital scoliosis: more than 3 year outcomes and analysis of unanticipated surgeries.",
        "abstract": "Until now there have been many reports on hemivertebra resection. But there were no large series on the posterior hemivertebra resection with bisegmental fusion. This is a retrospective study to evaluate the surgical outcomes of posterior hemivertebra resection only with bisegmental fusion for congenital scoliosis caused by fully segmented non-incarcerated hemivertebra.In our study, 36 consecutive cases (19 males, 17 females) diagnosed with congenital scoliosis, resulting from fully segmented non-incarcerated hemivertebra, treated by posterior hemivertebra resection with bisegmental fusion were investigated retrospectively, with at least a 3 year follow-up period (36-106 months).The total number of resected hemivertebra was 36. Mean operation time was 188.6 min with average blood loss of 364.2 ml. The segmental scoliosis was corrected from 36.6° to 5.1° with a correction rate of 86.1 %, and segmental kyphosis(difference to normal segmental alignment) from 21.2° to 5.8° at the latest follow-up. The correction rate of the compensatory cranial and caudal curve is 76.4 and 75.1 %. Unanticipated surgeries were performed on eight patients, including one delayed wound healing, two pedicle fractures, one progressive deformity and four implants removals.Posterior hemivertebra resection with bisegmental fusion allows for early intervention in very young children. Excellent correction can be obtained while the growth potential of the unaffected spine could be preserved well. However, it is not indicated for the hemivertebra between L5 and S1. The most common complication of this procedure is implant failure. Furthermore, in the very young children we noted that although solid fusion could be observed in the fusion level, implants migration may still happen during the time of adolescence, when the height of the body developed rapidly. So a close follow-up is necessary.",
        "keywords": [
            "bisegmetal fusion",
            "hemivertebra",
            "posterior instrumentation",
            "retrospective studies"
        ],
        "authors": [
            {
                "name": "Shengru Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jianguo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Guixing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Shugang Li",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Xisheng Weng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society",
        "year": 2013
    },
    "LQCoUSma": {
        "id": "LQCoUSma",
        "title": "A retrospective study of congenital scoliosis and associated cardiac and intraspinal abnormities in a Chinese population.",
        "abstract": "Our objective is to assess the incidence of cardiac and intraspinal abnormities in Chinese congenital scoliosis (CS) patients and to study the relationship between the associated abnormities and the different CS types. Five-hundred and thirty-nine consecutive Chinese patients with CS were retrospectively studied, and the records of echocardiography, plain radiograph of the entire spine, magnetic resonance imaging of the entire spine and/or myelogram were reviewed. The results indicated that the incidence of cardiac and intraspinal abnormities in CS patients was 14.1 and 24.5%, respectively. There was no difference in the incidence of associated cardiac and intraspinal abnormities in different CS types (P > 0.05). The most common cardiac abnormities in CS patients was mitral valve prolapse, which was followed by congenital heart diseases, including atrial septal defect, ventricular septal defect, bicuspid aortic valve and patent ductus ateriosus. The cardiac abnormities were not likely to be concurrent with intraspinal abnormities in CS patients (P = 0.04). The intraspinal abnormities were more common in female and older patients (all P < 0.05). One or more abnormities mentioned above could be found in 36.8% CS patients and were more likely to be found in female patients (P < 0.01). We concluded that CS is not a simple abnormity, due to the high incidence of associated deformities of other organs, comprehensive assessment was strongly recommended before the surgical correction for CS patients.",
        "keywords": [
            "china",
            "incidence",
            "spine",
            "retrospective studies"
        ],
        "authors": [
            {
                "name": "Yong-tai Liu",
                "org": "Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            },
            {
                "name": "Li-lin Guo",
                "org": "Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            },
            {
                "name": "Zhuang Tian",
                "org": "Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            },
            {
                "name": "Wen-ling Zhu",
                "org": "Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            },
            {
                "name": "Shu-yang Zhang",
                "org": "Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            },
            {
                "name": "Gui-xing Qiu",
                "org": "Department of Orthopaedics and Traumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China"
            }
        ],
        "venue": "European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society",
        "year": 2011
    },
    "7a2tSiLM": {
        "id": "7a2tSiLM",
        "title": "The changes of the interspace angle after anterior correction and instrumentation in adolescent idiopathic scoliosis patients.",
        "abstract": "In idiopathic scoliosis patients, after anterior spinal fusion and instrumentation, the discs (interspace angle) between the lowest instrumented vertebra (LIV) and the next caudal vertebra became more wedged. We reviewed these patients and analyzed the changes of the angle.By reviewing the medical records and roentgenograms of adolescent idiopathic scoliosis patients underwent anterior spinal fusion and instrumentation, Cobb angle of the curve, correction rate, coronal balance, LIV rotation, interspace angle were measured and analyzed.There were total 30 patients included. The mean coronal Cobb angle of the main curve (thoracolumbar/lumbar curve) before and after surgery were 48.9 degrees and 11.7 degrees , respectively, with an average correction rate of 76.1%. The average rotation of LIV before surgery was 2.1 degree, and was improved to 1.2 degree after surgery. The interspace angle before surgery, on convex side-bending films, after surgery, at final follow up were 3.2 degrees , -2.3 degrees , 1.8 degrees and 4.9 degrees , respectively. The difference between the interspace angle after surgery and that preoperatively was not significant (P = 0.261), while the interspace angle at final follow-up became larger than that after surgery, and the difference was significant(P = 0.012). The interspace angle after surgery was correlated with that on convex side-bending films (r = 0.418, P = 0.022), and the interspace angle at final follow-up was correlated with that after surgery (r = 0.625, P = 0.000). There was significant correlation between the loss of the interspace angle and the loss of coronal Cobb angle of the main curve during follow-up(r = 0.483, P = 0.007).The interspace angle could be improved after anterior correction and instrumentation surgery, but it became larger during follow-up. The loss of the interspace angle was correlated with the loss of coronal Cobb angle of the main curve during follow-up.",
        "keywords": [
            "medical records",
            "and",
            "orthopedics",
            "surgery"
        ],
        "authors": [
            {
                "name": "Yipeng Wang",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Guixing Qiu",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Jianguo Zhang",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Jiayi Li",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Xisheng Weng",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Jianxiong Shen",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Qi Fei",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "Qiyi Li",
                "org": "Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            }
        ],
        "venue": "Journal of orthopaedic surgery and research",
        "year": 2007
    },
    "l5SxrFww": {
        "id": "l5SxrFww",
        "title": "Posterior vertebra column resection and reconstruction for severe kyphosis",
        "abstract": "Objective: To investigate the feasibility and clinical significance of posterior vertebra column resection and reconstruction in the treatment of severe kyphosis. Methods: We retrospectively analyzed the clinical data of 12 patients with severe kyphosis who received posterior vertebra column resection and reconstruction from January 2003 to July 2007. Results: The mean operation time was 5. 0 h (4.0-7.8h) and the evaluated blood loss during operation was 1 800 ml (800-3000 ml). No neurologic complications or post-operative infections were noted. The patients became ambulatory 8 days after operation. Before operation, 5 patients were found to have neurological deficit, including Frankel grade A in 1 patient and D in 4 patients. After operation, the grades were all recovered to Frankel E. After operation, the Cobb angle of the kyphosis was corrected to 38°, with an average correction rate of 63%. Conclusions: Posterior vertebra column resection and reconstruction may be a safe and effective technique for the treatment of severe kyphosis. It can fully decompress the neurological structures, correct the kyphosis deformity, and achieve early weight-bearing. It is especially useful to avoid neurological injury.",
        "keywords": [
            "Posterior vertebra column resection",
            "Severe kyphosis",
            "Spinal osteotomy"
        ],
        "authors": [
            {
                "name": "Hong Zhao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Gui-Xing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-Guo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Ye Tian",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Shu-Gang Li",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2008
    },
    "iN6gR3h5": {
        "id": "iN6gR3h5",
        "title": "Modified PUMC Classification for Adolescent Idiopathic Scoliosis.",
        "abstract": "Modified PUMC classification presents incremental improvement compared to our original published version, with high inter-observer and intra-observer reliability and better performance of postoperative shoulder balance. Furthermore, the Modified PUMC classification provides corresponding surgical fusion guidance for each subtype. Multi-center prospective studies with larger samples are still needed to further improve this system.",
        "keywords": [
            "Idiopathic scoliosis",
            "classification",
            "selective fusion"
        ],
        "authors": [
            {
                "name": "Qianyu Zhuang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Guixing Qiu",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China. Electronic address: qgxpumch@126.com."
            },
            {
                "name": "Qiyi Li",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Jianguo Zhang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Jianxiong Shen",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Yipeng Wang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Hong Zhao",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Yu Zhao",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Shugang Li",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Xiao Chang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Shengru Wang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Siyi Cai",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Xi Zhou",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            },
            {
                "name": "Jinqian Liang",
                "org": "Department of Orthopaedics, Peking Union Medical College Hospital, No.1 Shuai-fu-yuan, Wang-fu-jing, Beijing 100730, China."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2019
    },
    "3VA64J3y": {
        "id": "3VA64J3y",
        "title": "An innovative broken pedicle screw retrieval instrument.",
        "abstract": "To introduce a new broken pedicle screw fragment retrieval instrument, and evaluate its clinical viability and effectiveness.Following basic retrieval contrivance of broken pedicle screws described in literature, a new retrieval instrument was designed and developed; introducing its mechanism, technical components, and use. This innovative apparatus proved successful not only in saw bone and cadaver trials but in 10 clinical cases as well.This particular unique instrument successfully retrieves broken pedicle screw fragments through original passage backing out the screw with preservation of pedicle integrity while maintaining pedicle biomechanics. No complications were observed.With solid scientific theoretical planning and experimentation, the new retrieval instrument design proved clinical practicality and efficacy.",
        "keywords": [
            "breakage",
            "design",
            "pedicle screw",
            "retrieval instrument"
        ],
        "authors": [
            {
                "name": "Xisheng Weng",
                "org": ""
            },
            {
                "name": "Guixing Qiu",
                "org": ""
            },
            {
                "name": "Junwei Li",
                "org": ""
            },
            {
                "name": "Shugang Li",
                "org": ""
            },
            {
                "name": "Chia-I Lee",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Lianhua Li",
                "org": ""
            }
        ],
        "venue": "Journal of spinal disorders & techniques",
        "year": 2007
    },
    "iFRSHtoZ": {
        "id": "iFRSHtoZ",
        "title": "Primary effect of dual growing rod technique for the treatment of severe scoliosis in young children.",
        "abstract": "Treatment of rapidly progressing scoliosis in young children is a challenge for spine surgeons. Some surgeons had begun to use dual growing rod technique for treatment of rapidly progressing scoliosis in young children and had achieved acceptable results. The aim of this study was to determine the primary results and complications of this new technique in China.Eleven children suffering from rapidly progressing scoliosis were treated with dual growing rod technique between November 2004 and March 2009 at Peking Union Medical College Hospital (PUMCH). There were 10 females and 1 male in the group with Risser sign of 0 grade. The mean age at initial surgery was 6.1 years (range, 2.1-10.9 years). Ten patients were diagnosed as congenital scoliosis and 1 patient neuromuscular scoliosis. All the patients had 1-4 lengthening procedures (mean, 1.8 procedures) after the initial surgeries. The radiographic results of all the patients were investigated.The coronal Cobb angle of scoliosis improved from (67.64+/-11.43) degrees to (34.64+/-8.26) degrees after initial surgery with the correction rate observed at (47.15+/-16.48)%. The coronal trunk shift improved from (2.00+/-1.73) cm to (1.49+/-1.31) cm after initial surgery. The T1-S1 height increased from (25.47+/-6.16) cm to (28.84+/-5.69) cm after initial surgery. The coronal Cobb angle of scoliosis was (36.82+/-11.76) degrees and the coronal trunk shift was (1.11+/-1.29) cm after the most recent lengthening procedure with the most recent correction rate observed at (44.73+/-19.43)%. The T1-S1 height was (31.29+/-4.50) cm after the most recent lengthening procedure with an average T1-S1 length increase of 1.6 (range, 1.0-2.7) cm per year during the lengthening period. The sagittal balance was maintained. Five of the total patients (45.5%) had complications including: hook displacement, pedical screw loosening, and broken rod. We performed revision surgeries with simultaneous lengthening procedures in all 5 cases with satisfactory results.The dual growing rod technique was useful in the management of rapidly progressing scoliosis in young children. This technique could control severe scoliosis, allow for spinal growth, and maintain the coronal and sagittal balance. But the technique has high complications requiring strict and regular follow-up.",
        "keywords": [
            "growing rods",
            "operation",
            "scoliosis"
        ],
        "authors": [
            {
                "name": "Qi-yi Li",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-guo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Gui-xing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yi-peng Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jian-xiong Shen",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yu Zhao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Shu-gang Li",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Xi Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Xi-sheng Weng",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2010
    },
    "VNT1lk7D": {
        "id": "VNT1lk7D",
        "title": "The influence of preoperative brace treatment on the pulmonary function test in female adolescent idiopathic scoliosis.",
        "abstract": "Retrospective study.To analyze the influence of preoperative brace treatment on the pulmonary function tests (PFTs) in females with adolescent idiopathic scoliosis (AIS).Brace is a selection of conservative treatment for some patients with AIS. Some authors reported that wearing a brace could impair the PFTs, although there are no reports that analyze the related factors.Preoperative PFTs were evaluated in 270 female patients with AIS. The patients were classified into 2 groups: group A, with preoperative brace treatment, 70 cases; and group B, without preoperative brace treatment, 200 cases. The differences of the PFTs between the 2 groups were compared.The predicted values of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) in group A and B were 3.26 L and 3.20 L, 2.78 L and 2.73 L, respectively, (both P>0.05). The actual values of FVC and FEV1 in group A and B were 2.61 L and 2.72 L, 2.37 L and 2.48 L, respectively, (both P>0.05). The percentage of actual value and predicted value of FVC(FVC%) and FEV1(FEV1%) in group A and B were 80.6% and 85.2%, 85.7% and 91.1%, respectively, and group A had significantly lower values when compared with those of group B (both P<0.05). This difference was significant in patients with a primary thoracic curve (166 cases) (P<0.05), whereas not in patients with a primary thoracolumbar/lumbar curve (104 cases) (P>0.05). In group A, there were significant correlations between the sagittal Cobb angle of the thoracic curve and the actual values of FVC and FEV1 and FVC% and FEV1% (both P<0.05).Preoperative brace treatment can reduce the FVC% and FEV1% in thoracic AIS. The sagittal Cobb angle of the thoracic curve may be the influential factors.",
        "keywords": [
            "pulmonary function test",
            "idiopathic scoliosis",
            "fvc",
            "fev1",
            "brace"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Yipeng Wang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Guixing Qiu",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jianxiong Shen",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Jianguo Zhang",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            },
            {
                "name": "Lifeng Lao",
                "org": "Peking Union Medical College(Peking Union Medical College Hospital,PUMC Hospital,Peking Union Medical College),Beijing,China"
            }
        ],
        "venue": "Journal of spinal disorders & techniques",
        "year": 2013
    },
    "jGreq2NK": {
        "id": "jGreq2NK",
        "title": "Comparative study of fully depleted and body-grounded non fully depleted SOI MOSFETs for high performance analog and mixed signal circuits",
        "abstract": "This paper compared the performance of conventional fully depleted (FD) SOI MOSFETs and body-grounded nonfully depleted (NFD) SOI MOSFETs for analog applications, A new low-barrier body-contact (LBBC) technology has been developed to provide effective body contact. Experimental results show that the NFD MOSFET&#39;s with LBBC structure give one order of magnitude higher output resistance, significantl...",
        "keywords": [
            "MOSFETs",
            "Silicon",
            "1f noise",
            "Threshold voltage",
            "Substrates",
            "Semiconductor films",
            "Contacts",
            "Immune system",
            "CMOS digital integrated circuits",
            "CMOS analog integrated circuits"
        ],
        "authors": [
            {
                "name": "Mansun Chan",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "Bin Yu",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "Zhi-Jian Ma",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "C. T. Nguyen",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": "Hu joined the Department of"
            },
            {
                "name": "P. K. Ko",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Electron Devices",
        "year": 1995
    },
    "GZY1sQqV": {
        "id": "GZY1sQqV",
        "title": "Punchthrough transient voltage suppressor for low-voltage electronics",
        "abstract": "Transient voltage suppressors for electronic circuits with power supply voltage of 3.3 V or lower are urgently needed but unavailable due to excessive leakage of low-voltage reversed p-n diodes. We analyzed several candidate device structures by using two-dimensional device simulation. Adopting the punchthrough mechanism in an n/sup +/p/sup +/p/sup -/n/sup +/ structure rather than the traditional ...",
        "keywords": [
            "Power supplies",
            "Low voltage",
            "Electronic circuits",
            "Diodes",
            "Analytical models",
            "Circuit simulation",
            "Leakage current",
            "Capacitance",
            "Clamps",
            "Power system protection"
        ],
        "authors": [
            {
                "name": "Ya-Chin King",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "Bin Yu",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "J. Pohlman",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": "Hu joined the Department of"
            }
        ],
        "venue": "IEEE Electron Device Letters",
        "year": 1995
    },
    "Urso6qV5": {
        "id": "Urso6qV5",
        "title": "Punchthrough diode as the transient voltage suppressor for low-voltage electronics",
        "abstract": "Protection devices for future low-voltage electronics are needed. Performances of a new punchthrough transient voltage suppressor (TVS) are analyzed with two-dimensional device simulation. Compared with the available low-voltage TVS constructed with a Zener diode, the punchthrough diode shows far superior leakage current and capacitance. These punchthrough TVS devices are satisfactory for applicat...",
        "keywords": [
            "Diodes",
            "Breakdown voltage",
            "Doping",
            "Leakage current",
            "Clamps",
            "Avalanche breakdown",
            "Capacitance",
            "Protection",
            "Circuit simulation",
            "Electric breakdown"
        ],
        "authors": [
            {
                "name": "Ya-Chin King",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "Bin Yu",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "J. Pohlman",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": "Hu joined the Department of"
            }
        ],
        "venue": "IEEE Transactions on Electron Devices",
        "year": 1996
    },
    "Q7KVYHRn": {
        "id": "Q7KVYHRn",
        "title": "Quarter-micrometre surface and buried channel PMOSFET modelling for circuit simulation",
        "abstract": "The modelling of PMOSFETs, with surface channels (SC) and buried channels (BC) down to deep quarter-micrometre, in BSIM (Berkeley short-channel IGFET model) is discussed for analogue/digital circuit simulation. Based on physical mobility, velocity saturation, threshold voltage and series drain/source resistance models with some special considerations for PMOSFETs, a unified I - V model describes the electrical characteristics of both NMOSFET and PMOSFETs, with surface channel and buried channel types. Because the model includes the major physical effects in state-of-the-art MOSFETs and contains many important process and geometry parameters, it can fit the measured data well and has a good scalability for both SC and BC PMOSFETs.",
        "keywords": [
            "threshold voltage",
            "digital circuits"
        ],
        "authors": [
            {
                "name": "Yuhua Cheng",
                "org": ""
            },
            {
                "name": "Min-chie Jeng",
                "org": ""
            },
            {
                "name": "Zhihong Liu",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Kiyotaka Imai",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "Semiconductor Science and Technology",
        "year": 1996
    },
    "WJwwWIvH": {
        "id": "WJwwWIvH",
        "title": "Hot-carrier-induced degradation in ultra-thin-film fully-depleted SOI MOSFETs",
        "abstract": "The charge-pumping measurement technique was successfully applied to submicron ( L eff = 0.35 μm) n-MOSFETs on ultra-thin (50 nm) SOI film. The hot-carrier-induced degradation is studied by examining the damages to both gate-oxide and buried-oxide (BOX) interfaces. We found that when stressed at maximum substrate current, interface-trap generation is still the primary cause for hot-carrier-induced degradation. Even for ultra-thin-film SOI devices, the hot-carrier-induced damage is locally confined to the gate-oxide interface and only minor damage is observed at the buried-oxide interface. The buried-oxide interface charging contributes less than 5% of the overall drain current degradation.",
        "keywords": [
            "charge pump",
            "thin film"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Electrical Engineering & Computer Sciences, University of California, Berkeley, CA 94720, USA"
            },
            {
                "name": "Zhi-Jian Ma",
                "org": "Department of Electrical Engineering & Computer Sciences, University of California, Berkeley, CA 94720, USA"
            },
            {
                "name": "George Zhang",
                "org": "Department of Electrical Engineering & Computer Sciences, University of California, Berkeley, CA 94720, USA"
            },
            {
                "name": "Chenming Hu",
                "org": "Department of Electrical Engineering & Computer Sciences, University of California, Berkeley, CA 94720, USA"
            }
        ],
        "venue": "Solid State Electronics",
        "year": 1996
    },
    "mVN2MI1A": {
        "id": "mVN2MI1A",
        "title": "Impact of Gate Microstructure on Complementary Metal-Oxide-Semiconductor Transistor Performance",
        "abstract": "",
        "keywords": [
            "microstructures",
            "complementary metal oxide semiconductor"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Dong-Hyuk Ju",
                "org": ""
            },
            {
                "name": "Nick Kepler",
                "org": ""
            },
            {
                "name": "Tsu-Jae King",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "Japanese Journal of Applied Physics",
        "year": 1997
    },
    "jcbZyBIU": {
        "id": "jcbZyBIU",
        "title": "Reverse short-channel effects and channel-engineering in deep-submicron MOSFETs: modeling and optimization",
        "abstract": "",
        "keywords": [
            "reverse short channel effect",
            "superposition principle",
            "predictive models",
            "optimization",
            "threshold voltage",
            "lower bound",
            "short channel effect"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "university of california"
            },
            {
                "name": "edward d nowak",
                "org": ""
            },
            {
                "name": "k noda",
                "org": ""
            },
            {
                "name": "chenming hu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 1996
    },
    "Z9mHC6M9": {
        "id": "Z9mHC6M9",
        "title": "Gate engineering for deep-submicron CMOS transistors",
        "abstract": "Gate depletion and boron penetration through thin gate oxide place directly opposing requirements on the gate engineering for advanced MOSFET&#39;s. In this paper, several important issues of deep-submicron CMOS transistor gate engineering are discussed. First, the impact of gate nitrogen implantation on the performance and reliability of deep-submicron CMOSFET&#39;s is investigated. The suppression of bo...",
        "keywords": [
            "Nitrogen",
            "Reliability engineering",
            "Boron",
            "CMOSFETs",
            "MOSFET circuits",
            "Transistors",
            "Implants",
            "MOS capacitors",
            "Capacitance-voltage characteristics",
            "Degradation"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Strategic Technol. Group, Adv. Micro Devices Inc., Sunnyvale, CA, USA"
            },
            {
                "name": "Dong-Hyuk Ju",
                "org": ""
            },
            {
                "name": "Wen-Chin Lee",
                "org": ""
            },
            {
                "name": "N. Kepler",
                "org": ""
            },
            {
                "name": "Tsu-Jae King",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Electron Devices",
        "year": 1998
    },
    "R2JFlOp0": {
        "id": "R2JFlOp0",
        "title": "Hot-carrier effect in ultra-thin-film (UTF) fully-depleted SOI MOSFETs",
        "abstract": "A systematic study was carried out on the hot-carrier (HC) effect in UTF FD SOI MOSFETs. It clarifies experimentally that even for very thin-film devices, the HC-induced damage is locally confined to the gate-oxide and only minor interface trap generation is caused on the BOX under front-channel stress. The BOX HC charging contributes less than 5% of the overall current degradation.",
        "keywords": [
            "mosfet",
            "hot carriers",
            "silicon-on-insulator",
            "thin film transistors",
            "box",
            "current degradation",
            "damage",
            "front-channel stress",
            "gate oxide",
            "hot-carrier effect",
            "interface traps",
            "ultra-thin-film fully-depleted soi mosfet",
            "silicon on insulator",
            "degradation",
            "thin film",
            "hot carrier injection"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA|c|"
            },
            {
                "name": "Zhi-Jian Ma",
                "org": ""
            },
            {
                "name": "Zhang, G.",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "Santa Barbara, CA, USA",
        "year": 1996
    },
    "U2yBbNGJ": {
        "id": "U2yBbNGJ",
        "title": "Electrical characterization of inversion layer carrier profile in deep-submicron p-MOSFETs",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": "university of california berkeley"
            },
            {
                "name": "kiyotaga imai",
                "org": "nec"
            },
            {
                "name": "chenming hu",
                "org": "university of california berkeley"
            }
        ],
        "venue": "Semiconductor Science and Technology",
        "year": 1997
    },
    "kJCNdZ1e": {
        "id": "kJCNdZ1e",
        "title": "Short-channel effect improved by lateral channel-engineering in deep-submicronmeter MOSFET's",
        "abstract": "The normal and reverse short-channel effect of LDD MOSFET's with lateral channel-engineering (pocket or halo implant) has been investigated. An analytical model is developed which can predict Vth as a function of Leff, VDS, VBS, and pocket parameters down to 0.1-μm channel length. The new model shows that the Vth roll-up component due to pocket implant has an exponential dependence on channel length and is determined roughly by (Np)¼Lp. The validity of the model is verified by both experimental data and two-dimensional (2-D) numerical simulation. On the basis of the model, a methodology to optimize the minimum channel length Lmin is presented. The theoretical optimal pocket implant performance is to achieve an Lmin approximately 55~60% that of a uniform-channel MOSFET without pocket implant, which is a significant (over one technology generation) improvement. The process design window of pocket implant is analyzed. The design tradeoff between the improvement of short-channel immunity and the other device electrical performance is also discussed",
        "keywords": [
            "ion implantation",
            "ldd mosfet",
            "semiconductor device models",
            "halo implant",
            "quasi-two-dimensional poisson equation",
            "channel length",
            "lateral channel-engineering",
            "design tradeoff",
            "pocket implant",
            "reverse short-channel effect",
            "two-dimensional numerical simulation",
            "dual-gate cmos process",
            "minimum channel length optimization",
            "analytical model",
            "0.1 mum",
            "pocket parameters",
            "threshold voltage",
            "short-channel effect",
            "deep-submicron mosfet",
            "short-channel immunity",
            "n-mosfet",
            "process design window",
            "mosfet",
            "electrical performance",
            "reverse short channel effect",
            "short channel effect",
            "process design",
            "doping",
            "predictive models",
            "numerical simulation",
            "cmos technology"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Clement H. J. Wann",
                "org": ""
            },
            {
                "name": "Edward D. Nowak",
                "org": ""
            },
            {
                "name": "Kenji Noda",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "Electron Devices, IEEE Transactions",
        "year": 1997
    },
    "IJcY6Tiq": {
        "id": "IJcY6Tiq",
        "title": "Characterization of inversion layer carrier profile in deep-submicron p-MOSFETs",
        "abstract": "In deep-submicron MOSFET, the thickness of gate oxide becomes comparable to that of the inversion layer. The finite inversion layer thickness results in deviation of device parameters from the conventional model. High transverse electric fields at Si/SiO/sub 2/ interface makes quantization effect observable even at room temperature. Several theoretical methods to obtain the inversion layer carrier profile were reported based on quantum mechanics (QM) solution. However a simple electrical method is much preferred. In this paper, a high-frequency small-signal C-V method is proposed to characterize the inversion layer profile in both surface-channel and buried-channel p-MOSFETs based upon the physical concept of dc centroid.",
        "keywords": [
            "mosfet",
            "carrier density",
            "characteristics measurement",
            "inversion layers",
            "si-sio/sub 2/",
            "buried-channel devices",
            "dc centroid",
            "deep-submicron p-mosfets",
            "inversion layer carrier profile",
            "quantization effect",
            "small-signal c-v method",
            "surface-channel devices",
            "transverse electric fields",
            "high frequency",
            "room temperature",
            "national electric code",
            "quantum mechanics",
            "electron devices",
            "quantization",
            "temperature"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA|c|"
            },
            {
                "name": "Imai, K.",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "Fort Collins, CO, USA",
        "year": 1997
    },
    "KDK8bBS5": {
        "id": "KDK8bBS5",
        "title": "Punchthrough transient voltage suppressor for EOS/ESD protection of low-voltage IC's",
        "abstract": "A silicon transient voltage suppresser (TVS) is presented for off-chip EOS/ESD protection of ICs with supply voltages ranging from 3.3 V down to 1.5 V. The np/sup +/p/sup -/n four-layer TVS operates in punchthrough mode instead of the avalanche mode as in conventional TVS diodes. Performance was investigated by device simulator TMA-MEDICI for several device structure options for ultra-low-voltage EOS/ESD protection.",
        "keywords": [
            "electrostatic discharge",
            "elemental semiconductors",
            "leakage currents",
            "monolithic integrated circuits",
            "overvoltage protection",
            "protection",
            "semiconductor diodes",
            "silicon",
            "transient response",
            "1.5 to 3.3 v",
            "eos/esd protection",
            "si",
            "tma-medici",
            "tvs diodes",
            "device simulator",
            "low-voltage ic",
            "np/sup +/p/sup -/n four-layer structure",
            "offchip protection",
            "punchthrough mode",
            "transient voltage suppressor",
            "low voltage",
            "chip"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Dept. of Electr. Eng. & Comput. Sci., California Univ., Berkeley, CA, USA|c|"
            },
            {
                "name": "Ya-Chin King",
                "org": ""
            },
            {
                "name": "Pohlman, J.",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": ""
            }
        ],
        "venue": "Phoenix, AZ, USA",
        "year": 1995
    },
    "4e6KCEyk": {
        "id": "4e6KCEyk",
        "title": "CMOS transistor reliability and performance impacted by gate microstructure",
        "abstract": "This paper investigate the impact of CMOS (complementary metal-oxide-semiconductor) gate microstructure on the reliability and performance of deep-submicrometer CMOS transistors. The amorphous silicon (α-Si) gate provides better capability for suppression of boron penetration in p+ doped gate p-channel MOSFETs, but gate depletion in the α-Si gate is slightly more severe than that of the poly-Si gate. The gate-length-dependent gate-depletion effect, in which the difference in linear gm between MOSFETs with two different gate microstructures shows a strong Lg-dependence, is reported and interpreted by impurity diffusion along the grain boundary. A gate nitrogen implant as an effective method for suppression of the boron diffusion is also discussed with emphasis on the impact on both device reliability and performance",
        "keywords": [
            "cmos integrated circuits",
            "mosfet",
            "doping profiles",
            "grain boundary diffusion",
            "integrated circuit design",
            "integrated circuit reliability",
            "integrated circuit testing",
            "ion implantation",
            "cmos gate microstructure",
            "cmos transistor performance",
            "cmos transistor reliability",
            "cmos transistors",
            "si",
            "si:b",
            "si:n",
            "sio2-si",
            "a-si gate",
            "amorphous silicon gate",
            "boron diffusion",
            "boron penetration suppression",
            "gate depletion",
            "gate microstructure",
            "gate nitrogen implant",
            "gate-length-dependent gate-depletion effect",
            "grain boundary impurity diffusion",
            "linear transconductance",
            "p+ doped gate p-channel mosfets",
            "poly-si gate",
            "reliability",
            "microstructure",
            "microstructures",
            "boron",
            "complementary metal oxide semiconductor",
            "grain boundary",
            "nitrogen",
            "cmos technology"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "university of california"
            },
            {
                "name": "tsujae king",
                "org": ""
            },
            {
                "name": "chenming hu",
                "org": ""
            },
            {
                "name": "donghyuk ju",
                "org": ""
            },
            {
                "name": "n kepler",
                "org": ""
            }
        ],
        "venue": "Lake Tahoe, CA",
        "year": 1997
    },
    "jvhaQG7P": {
        "id": "jvhaQG7P",
        "title": "Impact of nitrogen (N/sub 14/) implantation into polysilicon gate on high-performance dual-gate CMOS transistors",
        "abstract": "The effect of nitrogen (N/sub 14/)implant into dual-doped polysilicon gates was investigated. The electrical characteristics of sub-0.25-μm dual-gate transistors (both p- and n-channel), MOS capacitor quasi-static C-V curve, SIMS profile, poly-Si gate R/sub s/, and oxide Q/sub bd/ were compared at different nitrogen dose levels. A nitrogen dose of 5×10/sup 15/ cm/sup -2/ is the optimum choice at an implant energy of 40 KeV in terms of the overall performance of both p- and n-MOSFETs and the oxide Q/sub bd/. The suppression of boron penetration is confirmed by the SIMS profiles to be attributed to the retardation effect in bulk polysilicon with the presence of nitrogen. High nitrogen dose (1×10/sup 16/ cm/sup -2/) results in poly depletion and increase of sheet resistance in both unsilicided and silicided p/sup +/ poly, degrading the transistor performance. Under optimum design, nitrogen implantation into poly-Si gate is effective in suppressing boron penetration without degrading performance of either p- or n-channel transistors.",
        "keywords": [
            "ion implantation",
            "cmos integrated circuits",
            "cmos ic scaling",
            "0.25 mum",
            "mos capacitor quasi-static c-v curve",
            "p-channel transistors",
            "oxide charge to breakdown",
            "n dose level dependence",
            "b penetration suppression",
            "characteristics measurement",
            "40 kev",
            "nmosfet",
            "polysilicon gate",
            "secondary ion mass spectra",
            "poly-si gate sheet resistance",
            "mos capacitors",
            "rapid thermal annealing",
            "sims profile",
            "n/sub 14/ implantation",
            "n-channel transistors",
            "si:n",
            "mosfet",
            "retardation effect",
            "rta",
            "pmosfet",
            "dual-gate cmos transistors",
            "electrical characteristics",
            "implant energy",
            "degradation",
            "nitrogen",
            "boron",
            "annealing",
            "threshold voltage"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Robotics Institute, School of Computer Science"
            },
            {
                "name": "Dong-Hyuk Ju",
                "org": ""
            },
            {
                "name": "Nick Kepler",
                "org": ""
            },
            {
                "name": "Chenming Hu",
                "org": "Hu joined the Department of"
            }
        ],
        "venue": "Electron Device Letters, IEEE",
        "year": 1997
    },
    "chdyKzi2": {
        "id": "chdyKzi2",
        "title": "AN ANALYSIS ON THE SPATIAL ORGANIZING AND ITS MICROECONOMIC MECHANISM IN RURAL—URBAN TERRITORIAL SYSTEM",
        "abstract": "The spatial organizing of rural-urban territorial system is a process of allocation and re-engineer of economic resource of the territory.The behaviors of different spatial individuals is the main power,which include firm's choice on geographical location and the government's spatial arrangement as well as the spatial game theory among different individuals.The rural-urban territory can be regarded as a spatial self-organizing system based on market mechanism. The geographical location decision produces spatial disturbance,spatial marginal profits of different locations can be regarded as a order-making variable,and the changes of spatial marginal profit rate act as \"invisible hand\".In the end,the paper gives a brief explanation on the rural-urban spatial organizing of Gedian Development Zone in Ezhou city.",
        "keywords": [
            "spatial self-organizing",
            "spatial game theory",
            "rural—urban territorial system",
            "spatial organizing"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ,Hubei,China;Department of Urban and Environment Science,Xinyang Normal College,Xinyang ,Henan,China"
            },
            {
                "name": "ZENG Ju-xin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ,Hubei,China"
            },
            {
                "name": "LUO Jing",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ,Hubei,China"
            }
        ],
        "venue": "Economic Geography",
        "year": 2006
    },
    "OUXF1LF7": {
        "id": "OUXF1LF7",
        "title": "Empirical Research on the Renewal of Old Urban Area with the Institutional Transition and Evolution: A Case of Hanzheng Street,Wuhan City",
        "abstract": "There has been a series of large-scale renewal in our country since the reform and opening.This paper makes a research on the renewal of Hanzheng Street in the chronological order,which is divided into three stages.And it summarizes and analyzes the features of institutional transition in each stage from the aspects of the adjustments of national power structure,the development of land compensated use system and the reformation of housing system.Meanwhile,it discusses the role of institutional transition in the renewal and the existed problems.And comes up relevant conclusions: the political system changes of the city turn the renewal of the inner city to be the field which is easy to be neglected,the alternation of determinative objectives turns the inner city renewal into the stages where public power and the private right fight for their own profit;the essence of the development process of inner city renewal is the result of interaction between public power and private right.",
        "keywords": [
            "Hanzheng Street",
            "the inner city renewal",
            "the institutional transition",
            "the reform and opening-up"
        ],
        "authors": [
            {
                "name": "Hu Juan",
                "org": "College of Urban and Environmental Science,Central China Normal University,Wuhan ,China"
            },
            {
                "name": "Luo Jing",
                "org": "College of Urban and Environmental Science,Central China Normal University,Wuhan ,China"
            },
            {
                "name": "Yu Bin",
                "org": "College of Urban and Environmental Science,Central China Normal University,Wuhan ,China"
            },
            {
                "name": "Wu Yuling",
                "org": "College of Urban and Environmental Science,Central China Normal University,Wuhan ,China"
            }
        ],
        "venue": "Areal Research and Development",
        "year": 2012
    },
    "z5qmFj4b": {
        "id": "z5qmFj4b",
        "title": "ON SPATIAL OPTIMIZATION OF INDUSTRIAL DEVELOPMENT IN WUHAN URBAN CLUSTER",
        "abstract": "Wuhan urban cluster is a city compact region with Wuhan as the center.The long history of industrial development of Wuhan can be divided into three periods:the first period (1840～1949) is the beginning stage,the second one (1949～1994) refers to that of industrial structure strengthening,and the last one (1994～) is that of the industry system adjustment.Correspondingly,the sectional structure and the spatial structure of the regional industry appear to be typically centralized.Taking the added value of the regional manufacture in 2003 as the target,the degree of the spatial configuration of Wuhan City is 50.5%,and the degree of industrial configuration of the top ten manufacturing is 60.6%.According to this,though an incompact economic federation nowadays,it has some foundations to integrate the industries,space and innovation.Based on the statistical data from 2001～2004 of the 9 cities in Wuhan cluster,with indicators of annual average value-added and increment rate of manufacturing by industrial sector,and by means of calculating and analyzing its region industrial potential ability to develop,it is concluded that we can promote the development of special sectors with regional competitiveness through constructing industrial cluster networks based on iron and steel industry,automobile industry,and electric communication equipment manufacturing,which can make full use of industrial organization and expand function of innovation in Wuhan City.It is necessary to promote effectively the development of special sec- tors with regional competitiveness by taking relative policies and measures such as consummating the clus- ter networks programming,strengthening the region space connection and leading the development of in- dustrial convergenceetc.",
        "keywords": [
            "spatial optimization",
            "industrial cluster networks",
            "industrial development",
            "Wuhan urban cluster"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ,China;Department of Urban and Environment Science,Xinyang Normal University,Xinyang ,China"
            },
            {
                "name": "LI Xing-ming",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ,China"
            },
            {
                "name": "ZENG Ju-xin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ,China"
            }
        ],
        "venue": "Resources and Environment in the Yangtze Basin",
        "year": 2007
    },
    "7eCGTbrM": {
        "id": "7eCGTbrM",
        "title": "A Study on Changes and Optimization of Rural Landscape Pattern under the Background of Tourism Development",
        "abstract": "The development of rural tourism is based on the rural landscape resources. But the pattern of rural landscape has produced reverse changes under the background of tourism development, which has diminished rural characteristic of rural landscape and hinder the sustainable development of rural tourism. The paper thinks it is major approaches to regulate the rural tourism goal, manage human behaviors and control rural spatial pattern for optimizing rural landscape and stopping rural landscape reverse changes. Its essential conditions are to give full play to government functions such as leading, support, rules and guiding etc.",
        "keywords": [
            "rural tourism",
            "landscape changes",
            "landscape optimization",
            "rural landscape"
        ],
        "authors": [
            {
                "name": "DENG Mingyan",
                "org": " Center for Tourism Research, Leshan Teachers College, Leshan Sichuan , China"
            },
            {
                "name": "ZENG Juxin",
                "org": " College of Urban and Environmental Science, Huazhong Normal University, Wuhan Hubei , China"
            },
            {
                "name": "YU Bin",
                "org": " College of Urban and Environmental Science, Huazhong Normal University, Wuhan Hubei , China"
            },
            {
                "name": "LI Bohua",
                "org": " Dept. of Resources & Environment and Tourism Management, Hengyang Normal University, Hengyang Hunan , China"
            }
        ],
        "venue": "Ecological Economy",
        "year": 2010
    },
    "X7Rnvr4Z": {
        "id": "X7Rnvr4Z",
        "title": "The Border Effect and The Development of Border Region Between Conurbations",
        "abstract": "China has been stepping into a new spatial growing stage leaded by conurbation,which results in a new border region due to the interaction between the conurbations.Based on the differential analysis on the backbone industries,the article takes the conurbation as a relatively independent territorially economic system and puts forward the border effect model resulting from interaction between conurbations according to the basic principle,of which homogeneity brings about competition and heterogeneity induces cooperation.Xinyang City,located between the Wuhan conurbation and Zhongyuan conurbation,is took as the case study region.The research result shows that border effect model could measure the potential impacts on the border region from the interaction between the conurbations.For the current development stage,Xinyang City is exposed to a good intervention opportunity by the interaction between the Wuhan and Zhongyuan conurbations.In more detail,IO(intervention opportunity) remains the high level of 0.64~0.71(the average level is 0.69 per year) in 2000-2008 without the border effect emerging.During the time,UE(border effect) fluctuates between 0.16 and 0.31(the average is only 0.23),and the level grows to 0.37 dramatically in 2009.According to the analysis,the weak intervention capability of Xinyang City may contribute to the situation,which could conclude that the border effect is the result of external intervention opportunity and internal intervention capability.What is more,globalization and conurbation reconstruct the external development environment of the border region and exerts the important influence on it.The article divides the border region into three different development stage,which are localization-dominating,regionalization-dominating and globalization-dominating,represented by localization index(LI),regionalization index(RI) and globalization index(GI) respectively.This is a dynamic mechanism stage pattern different from classical characteristics stage pattern,by which we could seek the dynamic analysis and development direction of the border region.Through the empirical study of Xinyang City,a city is still situated in the localization-dominating stage,LI is large than 0.5(except some year) during 2000-2008,and slows down to 0.45 in 2009;RI grows to 0.55 above.All data illustrate that Xinyang City beings to step into the regionalization-dominating stage,but the globalization development keeps in the initial level since GI has been remained below 0.001 2.The conclusion basically could testify the Xinyang City’s current development situation,which is corresponded with the initial industrialization stage by Chenery.So the article proposes that the optimization of internal development environment,and the advance of inner intervention capability and regionalization process would be the future development strategy direction.",
        "keywords": [
            "border region",
            "Xinyang City",
            "Zhongyuan conurbation",
            "border effect",
            "Wuhan conurbation",
            "conurbation"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "School of Urban and Environment Science,Central China Normal University,Wuhan,Hubei ,China"
            },
            {
                "name": "LIU Ming-hua",
                "org": "School of Urban and Environment Science,Xinyang Normal University,Xinyang,Henan ,China"
            },
            {
                "name": "ZHU Li-xia",
                "org": "School of Urban and Environment Science,Central China Normal University,Wuhan,Hubei ,China"
            },
            {
                "name": "GAO Jun-bo",
                "org": "School of Urban and Environment Science,Xinyang Normal University,Xinyang,Henan ,China"
            },
            {
                "name": "ZENG Ju-xin",
                "org": "School of Urban and Environment Science,Central China Normal University,Wuhan,Hubei ,China"
            }
        ],
        "venue": "Scientia Geographica Sinica",
        "year": 2012
    },
    "1Dkp6ibj": {
        "id": "1Dkp6ibj",
        "title": "An analysis on rural-urban territorial system and its spatial organizing",
        "abstract": "A rural-urban territorial system is a spatial organizing pattern,in which there are the meaning of a region and the structure of central place system.It is also one of kinds of land-man territorial system,which is characterized bynonlinear co-relation and dynamic open-out and self-organizing circulation.The spatial organizing of a rural-urban territorial system is an economic activity.The essence is arranging and re-organizing process of economic resource within the territory,which is derived by the spatial behavioral subjects in and out the system.These subjects include inhabitants and factory owners and a local government.There are some spatial organizing paths in the system,which include the territorial networking of the spatial organizing key elements and the spatial co-relation with the outside.",
        "keywords": [
            "spatial organizing elements",
            "man-land territorial system",
            "spatial organizing",
            "rural-urban territorial system",
            "spatial organizing paths"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan "
            },
            {
                "name": "LUO Jing",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan ;Wuhan-Xinzhou Development Institute,Central China Normal University, Wuhan "
            }
        ],
        "venue": "Journal of Central China Normal University(Natural Sciences)",
        "year": 2005
    },
    "FFiCQPnH": {
        "id": "FFiCQPnH",
        "title": "INDUSTRIAL SPATIAL ORGANIZING BASED ON CLUSTER NETWORK IN WUHAN URBAN CLUSTER",
        "abstract": "Regional competence based on the economic globalization operate the demand of regional cooperation,and the strategy of urban cluster based on the economic integration was wildly canonized.Industrial cluster networks is a kind of spatial combination of regional industrial cluster,and,it is also a model of economic spatial organization with productive efficiency and innovative influence.Though Wuhan Urban Cluster is an incompact economic federation nowadays,it has some foundations to integrate the industries and spaces and innovation.According to the analytic results of industrial potential ability to develop,we can promote the development of special sectors with regional competitiveness through constructing regional cluster networks based on iron and steel industry,automobile industry,and electric & communication equipment manufacturing,which can make full use of industrial organization and expand function of innovation in Wuhan city.",
        "keywords": [
            "industrial cluster networks",
            "spatial organizing",
            "industrial development",
            "industrial cluster",
            "Wuhan Urban Cluster"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Center for Chinese Rural Studies,College of Urban and Environment Science,Central China Normal University,Wuhan ,Hubei,China;Department of Urban and Environment Science,Xinyang Normal University,Xinyang ,Henan,China"
            },
            {
                "name": "FENG Juan",
                "org": "Center for Chinese Rural Studies,College of Urban and Environment Science,Central China Normal University,Wuhan ,Hubei,China"
            },
            {
                "name": "ZENG Ju-xin",
                "org": "Center for Chinese Rural Studies,College of Urban and Environment Science,Central China Normal University,Wuhan ,Hubei,China"
            }
        ],
        "venue": "Economic Geography",
        "year": 2007
    },
    "0n62jWcG": {
        "id": "0n62jWcG",
        "title": "Spatial Innovation of Urban-rural Development in the Non-dense-town Region",
        "abstract": "The urban-rural development of non-dense-town region involves both spatial equity and general efficiency.The spatial effects of economic globalization maybe accelerate \"marginalization\" of non-dense-town region.Therefore,this region should choose the mode of urban-rural interaction development which its essence is the spatial connection of regional economy,including the spatial connection of the economic subjects,organizations,resources,information,etc.The spatial welfare economy studies the relationship between the spatial consumption form and the spatial utility distribution.The spatial consumption form refers to the spatial utilization way depending on the regional collocation of the economic resources,and the spatial utility distribution refers to the spatial segmentation of the economic resources efficiency.The essence of regional spatial structure is the consumption form of some certain regional space and the spatial welfare economy mode based on the regional spatial structure can provide the urban-rural development in the non-dense-town region with theoretical foundation.Both the urban-rural interaction development and the spatial structural innovation in the non-dense-town region are compatible to the regional development principles embodying both the spatial equity and general efficiency.The spatial structural innovation can effectively facilitate the development of the urban-rural interaction,in which the selection of enterprises location is the basic impulse in forming the regional spatial structure.The spatial intervention and administration of local government constitutes the leading force of the spatial structure.",
        "keywords": [
            "urban-rural interaction development",
            "non-dense-town region",
            "spatial structural innovation",
            "Spatial Welfare Economy"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan,Hubei "
            },
            {
                "name": "ZENG Ju-Xin",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan,Hubei "
            },
            {
                "name": "LUO Jing",
                "org": "College of Urban and Environment Science,Central China Normal University,Wuhan,Hubei "
            }
        ],
        "venue": "Scientia Geographica Sinica",
        "year": 2007
    },
    "64uuNcde": {
        "id": "64uuNcde",
        "title": "Regional competitive advangtage and spatial organization innovation of specific industry——take the Wuhan city encloses as example",
        "abstract": "Economic globalization has dramatically intensified regional competition. Both developing specific industries and constructing industrial cluster networks can promote regional competitive advantages. In order to build up regional industrial cluster networks, many beneficial ways should be adopted. First of all, pick up specific industries according to industrial condition, market demand and innovative climate. Secondly, construct spatial relationships through chains of value, innovation and industry. Thirdly, manufacture key nodes by industrial clusters in developmental zones. From the case study about Wuhan Urban cluster, we can reach the conclusion as follows: To construct eight regional cluster networks around Wuhan city, such as iron and steel industry, automobile industry, and IT equipment industry, etc, can make full use of Wuhan City’s diffusion function on industrial organization and innovation.",
        "keywords": [
            "regional industrial cluster networks",
            "regional competitive advantage",
            "regional specific industry",
            "Wuhan Urban Cluster"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": " College of urban and Environment Science,Huazhong Normal University, Wuhan ; Department of urban and Environment Science,Xinyang Normal University, Xinyang, Henan "
            },
            {
                "name": "ZENG Juxin",
                "org": " College of urban and Environment Science,Huazhong Normal University, Wuhan "
            },
            {
                "name": "LUO Jing",
                "org": " College of urban and Environment Science,Huazhong Normal University, Wuhan "
            }
        ],
        "venue": "Journal of Huazhong Normal University(Natural Sciences)",
        "year": 2007
    },
    "9Qfdjoz8": {
        "id": "9Qfdjoz8",
        "title": "SURVEILLANCE OF THE INFLUENZA IN WUHAN DURING 2006 TO 2007",
        "abstract": "Objective To understand the regular epidemic pattern of influenza in Wuhan from 2006-2007, so as to provide basis for preventing influenza.Methods Epidemiology, etiology and laboratory surveillance of influenza had been conducted to analyze the epidemic status of influenza in Wuhan in recent years.Results Among 1772550 outpatients, 185971 outpatients were Like Illness(ILI) influenza patients accounted for10.5%.A total of 294 virus strains had been isolated from 933 specimens selected from the ILI influenza patients.The subtypes arrangement were H1N1(37.8%), H3N2(25.5%), B / Victoria(18.0%) and B / Yamagata(19.0%), respectively.The serum antibody level of H3N2 in population was the highest among all the other subtypes.The influenza epidemic status in Wuhan showed to be bimodal pattern, and the proportion of visiting for ILI was in line with the viral isolation rate.The predominant subtype turned from H1N1 to H3N2 during the recent two years.Conclusion It is necessary to enhance the influenza surveillance in Wuhan area to prevent and control influenza.",
        "keywords": [
            "Influenza",
            "Virus isolation",
            "Surveillance",
            "Influenza-Like Illness(ILI)"
        ],
        "authors": [
            {
                "name": "ZHOU Yu",
                "org": "Wuhan Center for Disease Control and Prevention, Wuhan , China"
            },
            {
                "name": "LIN Xin-ming",
                "org": "Wuhan Center for Disease Control and Prevention, Wuhan , China"
            },
            {
                "name": "YU Bin",
                "org": "Wuhan Center for Disease Control and Prevention, Wuhan , China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2008
    },
    "A9ACDnEP": {
        "id": "A9ACDnEP",
        "title": "Prevalent features of hepatitis E among residents in Wuhan from 2001 to 2010",
        "abstract": "Objective To analyze the incidence and epidemiological trend of hepatitis E(HE) among residents in Wuhan from 2001 to 2010.Methods Descriptive epidemiological and correlation analytical methods were used.Results Totally 5 011 cases of HE were reported in Wuhan from 2001 to 2010,with an average incidence of 6.20 per 100 000 and a downward trend(χ2=836.53,P<0.001).No obvious seasonal distribution was observed for the reported HE cases,but the incidence was relatively higher in winter and spring.The average incidence of HE was higher in the urban than in the rural(χ2=1 284.65,P<0.001).The incidence of HE increased with the increment of age(r=0.816,P<0.001)and was the highest in the risidents aged 55 to 84 years,and higher in male than in female(χ2=848.01,P<0.001).Among the all cases,retirees accounted for 28.46 percent and workers were 16.74 percent.Conclusion In recent years,the incidence of HE was high among the residents in Wuhan city and was higher in urban residents,male population,retirees,and the people aged over fifty.",
        "keywords": [
            "epidemiology",
            "incidence",
            "hepatitis E"
        ],
        "authors": [
            {
                "name": "KONG De-guang",
                "org": "Department of Infectious Disease,Wuhan Municipal Center for Disease Control and Prevention,Wuhan,Hubei Province ,China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Infectious Disease,Wuhan Municipal Center for Disease Control and Prevention,Wuhan,Hubei Province ,China"
            },
            {
                "name": "LUO Tong-yong",
                "org": "Department of Infectious Disease,Wuhan Municipal Center for Disease Control and Prevention,Wuhan,Hubei Province ,China"
            }
        ],
        "venue": "Chinese Journal of Public Health",
        "year": 2012
    },
    "lbvUoWIC": {
        "id": "lbvUoWIC",
        "title": "Logistic regression analysis on the influencing factors of severe cases of HFMD in Wuhan City",
        "abstract": "Objective To investigate and analyze the influencing factors of severe cases of hand foot and mouth disease(HFMD).Methods Data on HFMD cases was collected from hospital by using self-designed questionnaire,retrospective survey of treatment and non-matched case-control study.Related risk factors were identified using uni-variate and multivariate logistic regression.Results Uni-variate logistic regression analysis results showed that Diaspora pattern,migrant,first diagnosed medical institutions,diagnosed on HFMD in the first visit to hospital and referrals had statistical significance.Multivariate logistic regression analysis showed that factors as living outside Wuhan,more than 3 referrals,and longer course of disease were found associated with serve cases of HFMD.Conclusions Reducing the number of multi-regional referrals and visiting local general hospital promptly were the effective action to prevent the development to severe cases of HFMD,and was of significance for monitoring severe HFMD and reducing HFMD mortality.",
        "keywords": [
            "Influencing factors",
            "Logistic regression",
            "HFMD"
        ],
        "authors": [
            {
                "name": "YANG Xiao-bing",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "ZHOU Xiao-qi",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "KONG De-guang",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "YU Bin",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            }
        ],
        "venue": "Journal of Public Health and Preventive Medicine",
        "year": 2012
    },
    "bvBdH4N6": {
        "id": "bvBdH4N6",
        "title": "Analysis of monitoring pathogenic bacterium of bacillary dysentery between 2006 and 2007 in Wuhan",
        "abstract": "Objective:Understanding the biochemistry serology typing,distribution of related virulence genes and drug sensitive state of Shigella,which is the pathogenic bacterium of bacillary dysentery to provide evidence for clinical treat and Control and Prevention in bacillary dysentery.Methods:According to monitoring of pathogenic bacterium of bacillary dysentery in China,we do the separation and identification of pathogenic and bacterium drug sensitive test.And polymerase chain reaction(PCR) were also used to detect related virulence genes of Shigella,in which eight primers such as set1A,set1B,shet2A,shet2B,ial,ipaH,stx1 and virA were used.Results:In 539 specimens of bacillary dysentery by clinical initial diagnosis,17were identified by biochemistry and serology.The rate was 3.2%.15 were of S.sonnei,2 of S.flexneri.ipaH of positive in 27 by PCR,and the rate is 5.0%.the 17 positive straits by separation & identification were all ipaH positive.There was some difference in the distribution of related virulence genes between S.flexneri and S.sonnei.All the 17straits were sensitive to amoxicillin and ciprofloxacin.while allwere drug resistance to rifampicin.Five of which were drug resistant to three or more than three kinds of antibiotics.Conclution:Most of the pathogenic bacterium in bacillary dysentery is S.sonnei,secondary is S.flexneri in wuhan between 2006 to 2007.The positive rate is is higher by ipaH-PCR than traditional separation and identification.More importantly,many are drug resistant to the commonly used antibiotics at present.",
        "keywords": [
            "Drug sensitivity",
            "Bacillary dysentery",
            "Shigella",
            "Related virulence genes",
            "PCR"
        ],
        "authors": [
            {
                "name": "Xiong Yan",
                "org": "Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "Luo Tong-yong",
                "org": "Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "Yu Bin",
                "org": "Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "Jiang Yuan-shan",
                "org": "Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "Long Yi-bing",
                "org": "Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "Zhou Jun-bo",
                "org": "Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2008
    },
    "C5dSQvnP": {
        "id": "C5dSQvnP",
        "title": "A cross-sectional study on the cases of hepatitis B reported in Wuhan, Hubei province in 2010]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Tong-yong Luo",
                "org": "Wuhan City Center for Disease Control and Prevention, China."
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Quan Hu",
                "org": ""
            },
            {
                "name": "Jian Chen",
                "org": ""
            },
            {
                "name": "Dun-jin Kong",
                "org": ""
            },
            {
                "name": "Hong Du",
                "org": ""
            },
            {
                "name": "Qiu-ling Li",
                "org": ""
            },
            {
                "name": "Bang-hua Cheng",
                "org": ""
            },
            {
                "name": "Dun-jin Zhou",
                "org": ""
            }
        ],
        "venue": "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi",
        "year": 2011
    },
    "YzAp7VMr": {
        "id": "YzAp7VMr",
        "title": "Epidemic character of Japanese B encephalitis in Wuhan(1992-2006)",
        "abstract": "Objective To analyze the epidemiological characteristics of epidemic encephalitis B in 1992~2006 in Wuhan city and provide data for prevention and control strategy.Methods The reported cases of Japanese B Encephalitis(JBE)from the Wuhan Center for Disease Control and Prevention were analyzed by descriptive epidemiology.Results From 1992 to 2006,the accumulated total number was 433 JE and 10 deaths.The annual average morbidity and fatality rate were 0.41/100 000 and 2.31% respectively,the average incidence rate was obviously reduced every year,and there was no case reported in 2005 and 2006.The epidemic season was from April to September and the peak was from July to August.Almost all JBE cases were in the suburbs,such as Xinzhou district(39.72%)、Huangpi district(31.87%)、Jiangxia district(12.24%).664).Cases of children age<15 accounted for 94.23%(408/433).Children living scattered accounted for 61.20%(265/433).Conclusion During 1992~2006,JE was sporadic in Wuhan city,and the seasonal variation of JE was obvious.Most of the cases were from zero to 15 years old.It showed that in recent years JE was controlled effectively,however,surveillance,prevention and control of JE should not be neglected.",
        "keywords": [
            "Japanese encephalitis",
            "Epidemiology"
        ],
        "authors": [
            {
                "name": "CHEN Bang-hua",
                "org": ". Wuhan Centers for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "HU Quan",
                "org": ". Wuhan Centers for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "YU Bin",
                "org": ". Wuhan Centers for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "LIU Pu-lin",
                "org": ". Wuhan Centers for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "GAO Li",
                "org": ". Wuhan Centers for Disease Control and Prevention,Wuhan ,China"
            }
        ],
        "venue": "Journal of Public Health and Preventive Medicine",
        "year": 2007
    },
    "VbWWkR0i": {
        "id": "VbWWkR0i",
        "title": "Prediction analysis for typhoid and paratyphoid fever with GM(1,1) grey model in Wuhan",
        "abstract": "Objective To predict the incidence trend of typhoid and paratyphoid fever in Wuhan city,and provide reference for policy making.Methods According to the incidence data of typhoid and paratyphoid fever in Wuhan city from 2000 to 2009,the predicting model using grey system theory was established to carry out the predicting research.Results The grey model was(t+1)=-11.784 809e-0.118 065+13.994 809.The goodness-of-fit test indicated that the precision(degree 1) was qualified(C=0.358,P=1.000) and the model was capable in predicting the incidence of typhoid and paratyphoid fever..Conclusions The results indicate that the incidence of typhoid and paratyphoid fever will continue to decrease from 2012 to 2014,however,it is still necessary to strengthen comprehensive prevention and control measures,including: improvement of drinking water hygiene,strengthening of health monitoring and health education,so as to reduce the Incidence of typhoid and paratyphoid fever.",
        "keywords": [
            "GM(1",
            "Predicting",
            "1)",
            "Typhoid and paratyphoid fevers",
            "Grey model"
        ],
        "authors": [
            {
                "name": "YANG Xiao-bing",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "KONG De-guang",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "YU Bin",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            }
        ],
        "venue": "Journal of Public Health and Preventive Medicine",
        "year": 2012
    },
    "LPtOHdJp": {
        "id": "LPtOHdJp",
        "title": "Early warning on measles through the neural networks]",
        "abstract": "To discuss the effects on early warning of measles, using the neural networks. Based on the available data through monthly and weekly reports on measles from January 1986 to August 2006 in Wuhan city. The modal was developed using the neural networks to predict and analyze the prevalence and incidence of measles. When the dynamic time series modal was established with back propagation (BP) networks consisting of two layers, if p was assigned as 9, the convergence speed was acceptable and the correlation coefficient was equal to 0.85. It was more acceptable for monthly forecasting the specific value, but better for weekly forecasting the classification under probabilistic neural networks (PNN). When data was big enough to serve the purpose, it seemed more feasible for early warning using the two-layer BP networks. However, when data was not enough, then PNN could be used for the purpose of prediction. This method seemed feasible to be used in the system for early warning.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Wuhan Center for Disease Control and Prevention, Wuhan 430015, China."
            },
            {
                "name": "Chun Ding",
                "org": ""
            },
            {
                "name": "Shan-bo Wei",
                "org": ""
            },
            {
                "name": "Bang-hua Chen",
                "org": ""
            },
            {
                "name": "Pu-lin Liu",
                "org": ""
            },
            {
                "name": "Tong-yong Luo",
                "org": ""
            },
            {
                "name": "Jia-gang Wang",
                "org": ""
            },
            {
                "name": "Zhi-wei Pan",
                "org": ""
            },
            {
                "name": "Jun-an Lu",
                "org": ""
            }
        ],
        "venue": "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi",
        "year": 2011
    },
    "xuX4HQJy": {
        "id": "xuX4HQJy",
        "title": "Epidemiological characteristics of hand-foot-mouth disease in Wuhan in 2008-2011",
        "abstract": "Objective To understand the epidemiological characteristics of hand foot and mouth disease(HFMD)in Wuhan from 2008 to 2011,and to provide scientific evidence for the prevention and control of the disease.Methods A descriptive epidemiological analysis was conducted on the incidence data of HFMD reported during this period in Wuhan city.Results A total of 40 482 HFMD cases were reported with the average annual incidence of 117.91 per 100 000 population.The incidence of severe cases was 0.02% and the average annual mortality was 0.01/ 100 000.The highest average annual morbidity(169.82/100 000)was reported in Dongxihu district and the lowest(44.19)in Hannan district.There was statistically difference of incidence among districts(P<0.01).The average annual morbidity rate of male was 145.68,which was higher than that of female(88.43 per 100 000 population)(P<0.001).The incidence was the highest among children aged 0-4,accounting for over 50% of all cases each year(P<0.01).Conclusions It is clear that HFMD occurs with preference of age,season,gender and region.Younger age and male children are more vulnerable to suffer from HFMD and more likely to develop severe cases and die from EV71 infection.",
        "keywords": [
            "Analysis",
            "Hand foot and mouth disease",
            "Epidemiological characteristics"
        ],
        "authors": [
            {
                "name": "YANG Xiao-bing",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "KONG De-guang",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "YU Bin",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            }
        ],
        "venue": "Chinese Preventive Medicine",
        "year": 2013
    },
    "GXbilcMe": {
        "id": "GXbilcMe",
        "title": "Application of seasonal auto-regressive integrated moving average model in forecasting the incidence of hand-foot-mouth disease in Wuhan, China.",
        "abstract": "Outbreaks of hand-foot-mouth disease (HFMD) have occurred many times and caused serious health burden in China since 2008. Application of modern information technology to prediction and early response can be helpful for efficient HFMD prevention and control. A seasonal auto-regressive integrated moving average (ARIMA) model for time series analysis was designed in this study. Eighty-four-month (from January 2009 to December 2015) retrospective data obtained from the Chinese Information System for Disease Prevention and Control were subjected to ARIMA modeling. The coefficient of determination (R ), normalized Bayesian Information Criterion (BIC) and Q-test P value were used to evaluate the goodness-of-fit of constructed models. Subsequently, the best-fitted ARIMA model was applied to predict the expected incidence of HFMD from January 2016 to December 2016. The best-fitted seasonal ARIMA model was identified as (1,0,1)(0,1,1), with the largest coefficient of determination (R =0.743) and lowest normalized BIC (BIC=3.645) value. The residuals of the model also showed non-significant autocorrelations (P =0.299). The predictions by the optimum ARIMA model adequately captured the pattern in the data and exhibited two peaks of activity over the forecast interval, including a major peak during April to June, and again a light peak for September to November. The ARIMA model proposed in this study can forecast HFMD incidence trend effectively, which could provide useful support for future HFMD prevention and control in the study area. Besides, further observations should be added continually into the modeling data set, and parameters of the models should be adjusted accordingly.",
        "keywords": [
            "auto-regressive integrated moving average (ARIMA)",
            "forecast",
            "hand-foot-mouth disease",
            "modeling",
            "surveillance"
        ],
        "authors": [
            {
                "name": "Ying Peng",
                "org": "Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China."
            },
            {
                "name": "Bin Yu",
                "org": "Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China."
            },
            {
                "name": "Peng Wang",
                "org": "Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China."
            },
            {
                "name": "De-Guang Kong",
                "org": "Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China."
            },
            {
                "name": "Bang-Hua Chen",
                "org": "Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China."
            },
            {
                "name": "Xiao-Bing Yang",
                "org": "Wuhan Centers for Disease Prevention and Control, Wuhan, 430015, China. yangxiaobingnn@163.com."
            }
        ],
        "venue": "Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban",
        "year": 2017
    },
    "NNUORWnV": {
        "id": "NNUORWnV",
        "title": "Qualitative study on syndromic surveillance to medical staff of hospital conducted syndromic surveillance in Wuhan",
        "abstract": "Objective To identify the attitude of medical staff toward syndromic surveillance.Methods Through the qualitative study method,the medical staff were investigated by questionnaire and interview after the project.Results It was recognized that syndromic surveillance played pivotal roles in early detection of public health events and was a beneficial supplement for traditional diseases surveillance.Whereas,it was too difficult to conduct under fully manual registration,collection and reporting data.Conclusions The electronic surveillance combined with the hospital information system should be the trend for syndromic surveillance.",
        "keywords": [
            "Respiratory tract infections",
            "Syndromic surveillance",
            "Medical staff",
            "Qualitative research"
        ],
        "authors": [
            {
                "name": "LUO Tong-yong",
                "org": ".1.Institute for Infectious Disease Control and Prevention,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "YU Bin",
                "org": ".1.Institute for Infectious Disease Control and Prevention,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "CHEN Bang-hua",
                "org": ".1.Institute for Infectious Disease Control and Prevention,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "LIU Pu-lin",
                "org": ".1.Institute for Infectious Disease Control and Prevention,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "WANG Jian-kun",
                "org": "Qiaokou District Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "HU Quan",
                "org": ".1.Institute for Infectious Disease Control and Prevention,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "ZHOU Dun-jin",
                "org": ".1.Institute for Infectious Disease Control and Prevention,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "WEI Shan-bo",
                "org": "Wuhan Health Bureau,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Disease Control & Prevention",
        "year": 2011
    },
    "JjWIFETm": {
        "id": "JjWIFETm",
        "title": "Investigation on the distribution of avian influenza virus in external environment and the level of H5N1 antibody in poultry-exposed population in Wuhan]",
        "abstract": "To survey the distribution of influenza A subtypes in external environment and investigate the infectious status of highly pathogenic avian influenza (H5N1) in poultry-exposed population in Wuhan.Seventy-eight external environmental samples (water, cage surface and fecal samples) were collected from 3 habitats of wild migratory birds and 5 urban live-poultry markets in 2010. In 13 avian influenza monitoring points, 249 serum samples were collected from people living around habitats of wild migratory birds or working in live poultry markets. Real-time RT-PCR method was adopted to detect influenza A virus from external environmental samples; and multiple RT-PCR method and specific H3, H5, H7 and H9 primers were then applied to analyze the subtypes of the positive samples. The levels of H5N1 antibody in poultry-exposed population were tested by horse hemagglutination inhibition test and two avian influenza inactivated antigens: A/Hubei/1/10 and A/Anhui/1/05.Of the 50 external environmental samples collected from live poultry markets, 17 samples were determined to be influenza A virus positive (positive rate 34.0%), including specific subtypes as follows: 4 samples of H5 single-positive subtype, 3 samples of H9 single-positive subtype, 4 samples of H3 and H5 mixed-positive subtype, 2 samples of H3 and H9 mixed-positive subtype, 2 samples of H5 and H9 mixed-positive subtype, 2 samples of H3, H5 and H9 mixed-positive subtype, but no H7 positive subtype was found. The 28 external environmental samples collected from habitats of wild migratory birds were all influenza A virus negative. Considering different types of external environmental samples, the influenza A virus positive rates in water, cage surface and fecal samples were 37.5% (6/16), 16.7% (5/30) and 18.8% (6/32), respectively. There were total 100 samples of serum whose A/Hubei/1/10 antigen inhibiting titers ≥ 40, accounting for 40.2%; while 36 samples of serum (14.5%) whose A/Anhui/1/05 antigen inhibiting titers ≥ 40 were found. The difference had statistical significance (χ(2) = 41.433, P < 0.05). Among the 249 serum samples collected from poultry-exposed population, 5 samples were H5N1 antibody positive against A/Hubei/1/10 antigen (inhibition titer ≥ 160), which came from 4 different live poultry markets, however, no positive serum sample against A/Anhui/1/05 antigen was found.Multiple subtypes of avian influenza virus simultaneously prevailed in Wuhan urban poultry markets. Moreover, results from the distribution of avian influenza virus in external environment were consistent with the level of H5N1 antibody in poultry-exposed population.",
        "keywords": [],
        "authors": [
            {
                "name": "Ying Wang",
                "org": "Virus Laboratory, Wuhan Centres for Disease Prevention and Control, Wuhan 430015, China."
            },
            {
                "name": "Wen-hua Kong",
                "org": ""
            },
            {
                "name": "Hong-hao Zhu",
                "org": ""
            },
            {
                "name": "Tong-yong Luo",
                "org": ""
            },
            {
                "name": "Xin-ming Lin",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Bang-hua Chen",
                "org": ""
            },
            {
                "name": "Quan Hu",
                "org": ""
            },
            {
                "name": "Jin-song Peng",
                "org": ""
            }
        ],
        "venue": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
        "year": 2011
    },
    "cajuFJXi": {
        "id": "cajuFJXi",
        "title": "Analysis of the Results of Surveillance on Communicable Diseases in Schools and Kindergartens from 2005 to 2007 in Wuhan City",
        "abstract": "Objective To understand the epidemic characteristics of common communicable diseases in schools and kindergartens and to take effective control in Wuhan city.Methods Totally 117 middle schools,primary schools and kindergartens were sampled to monitor common contagious diseases by stratified sampling.Data from Chinese disease prevention and control information system on school-aged children and preschool-aged children were download and compared to the surveillance data.Results Most of school and kindergarten epidemic diseases were respiratory infectious diseases such as chicken pox,mumps.About 66.67% of public health emergencies occurred in schools and kindergartens from 2005 to 2007 in Wuhan city.Respiratory infectious diseases took 85.71% of epidemic outbreaks in schools,64.29% of which took place in primary schools.It was important approach for detecting school outbreaks to enhance infectious disease register in medical institutions.Conclusion The results of surveillance on common contagious diseases can really reflect epidemic status of school infectious diseases.It is economical and effective measure for protecting children health to strengthen children's vaccinating against respiratory infectious diseases.",
        "keywords": [
            "Student health services",
            "Population surveillance",
            "Communicable diseases",
            "Prevalence"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ",et al.Center for Disease Control and Prevention of Wuhan City,Wuhan%%#%%#,China"
            },
            {
                "name": "CHEN Jian",
                "org": ",et al.Center for Disease Control and Prevention of Wuhan City,Wuhan%%#%%#,China"
            },
            {
                "name": "LUO Tong-yong",
                "org": ",et al.Center for Disease Control and Prevention of Wuhan City,Wuhan%%#%%#,China"
            }
        ],
        "venue": "Chinese Journal of School Health",
        "year": 2008
    },
    "owSGw3me": {
        "id": "owSGw3me",
        "title": "Circulation of human metapneumovirus among children with influenza-like illness in Wuhan, China.",
        "abstract": "Human metapneumovirus (HMPV) is a worldwide distributed pathogen of the respiratory tract. The objectives of this study were to identify HMPV infections among children with influenza-like illness (ILI) in Wuhan and to assess circulation patterns and molecular diversity of HMPV in this area. From July 2008 to December 2013, a total of 3,883 throat swab samples were collected from ILI outpatients under 16 years old. HMPV RNA was detected in 171 samples (4.40%). All the four subtypes of HMPV were identified, among which A2 was the most common subtype (61/145, 42.1%), followed by B1, B2, and A1. During the study period, HMPV circulation presented a biennial alternation between high and low incidence in Wuhan and the seasonal peak also shift between winter and spring in two continuous seasons. Subtype A2, B1, and B2 co-circulated during the study period, with genotype A prevailing in epidemic season 2008-2009 and 2012-2013, and genotype B prevailing during other periods. This large-scale analysis of HMPV prevalence in ILI outpatient children improves the understanding of local HMPV circulation patterns and provides molecular epidemic evidence for comparative analysis of HMPV infection. (c) 2015 Wiley Periodicals, Inc.",
        "keywords": [
            "human metapneumovirus",
            "epidemiology",
            "children",
            "China"
        ],
        "authors": [
            {
                "name": "Wenhua Kong",
                "org": "Wuhan Ctr Dis Prevent & Control, Dept Virol, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Ying Wang",
                "org": "Wuhan Ctr Dis Prevent & Control, Dept Virol, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Honghao Zhu",
                "org": "Wuhan Ctr Dis Prevent & Control, Dept Virol, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Xinming Lin",
                "org": "Wuhan Ctr Dis Prevent & Control, Dept Virol, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Wuhan Ctr Dis Prevent & Control, Inst Infect Dis, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Quan Hu",
                "org": "Wuhan Ctr Dis Prevent & Control, Inst Infect Dis, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Xiaobing Yang",
                "org": "Wuhan Ctr Dis Prevent & Control, Inst Infect Dis, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Deyin Guo",
                "org": "Wuhan Univ, State Key Lab Virol, Wuhan 430072, Hubei, Peoples R China"
            },
            {
                "name": "Jinsong Peng",
                "org": "Wuhan Ctr Dis Prevent & Control, Dept Virol, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            },
            {
                "name": "Dunjin Zhou",
                "org": "Wuhan Ctr Dis Prevent & Control, Inst Infect Dis, Jiang Han Bei Lu 24, Wuhan 430015, Hubei, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF MEDICAL VIROLOGY",
        "year": 2016
    },
    "FXyOd8x7": {
        "id": "FXyOd8x7",
        "title": "Analysis of Shigella strains isolated from Wuhan(2010)",
        "abstract": "Objective To understand the biochemical serology typing,drug sensitivity and distribution of the virulence genes of Shigella,which was the pathogenic bacterium of bacillary dysentery of Wuhan in 2010.Methods According to the national surveillance program of bacillary dysentery,separation and identification of pathogenic and bacterium drug sensitive test were performed.Polymerase chain reaction(PCR) was used to detect 7 related virulence genes of Shigella.Results During the surveillance period in 2010,15 shigella strains were isolated,among them,12 were Flenner,3 were Sonne.Drug sensitivity test showed that Shigella-sensitive drugs were: amoxicillin(66.7%),norfloxacin(73.3%),ciprofloxacin(60%).All are resistant to rifampin(100%),ampicillin(100%),nalidixic acid(100%).The positive rates of ipaH,ial,virA and sen genes were 100%,73.3%,73.3%and 73.3% respectively.The setlA and setlB were only detected in S.flexneri strains.Conclusions Most of the pathogenic bacterium in bacillary dysentery was S.sonnei in Wuhan in 2010.Drug resistance has become increasingly serious in these years.The mode of virulence genes carried by Shigella was rather simple.",
        "keywords": [
            "Virulence genes",
            "Drug sensitive",
            "Shigella",
            "Serology typing"
        ],
        "authors": [
            {
                "name": "WANG Fang",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "YU Bin",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "CHEN Zhi",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "JIANG Yuan-shan",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "ZENG Ying-chun",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "ZHOU Jun-bo",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "LONG Yi-bing",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            },
            {
                "name": "XIONG Yan",
                "org": " Wuhan Center for Disease Control and Prevention,Wuhan,Hubei ,China"
            }
        ],
        "venue": "Journal of Public Health and Preventive Medicine",
        "year": 2011
    },
    "m0vrYNzh": {
        "id": "m0vrYNzh",
        "title": "Epidemiological characteristics of influenza virus and respiratory syncytial virus among children in Wuhan area from 2008 to 2012]",
        "abstract": "To investigate the infection status and epidemiological characteristics of influenza virus and respiratory syncytial virus (RSV) in influenza-like illness (ILI) of children ( ≤ 14 years) in Wuhan area from 2008 to 2012.A total of 2854 cases of ILI patients ( ≤ 14 years) in a hospital of Wuhan were recruited in the study from July 2008 to June 2012. The sample of pharyngeal swab was collected from each patient, to extract the virus nucleic acids. Real-time fluorescent quantitation reverse transcription PCR (RT-PCR) method was applied to detect the subtypes of influenza virus and RSV, and then analyzed the time and age characteristics.Out of the 2854 cases, 758 (26.6%) were positive for influenza virus,including 547 (19.2%) influenza A virus positive samples and 211 (7.4%) influenza B virus positive samples. Usually, there were two peaks present in the annual curve of influenza virus, namely summer peak and winter/spring peak. The positive rate of influenza virus in 6-14 years old children (48.0%, 275/573) was significantly higher than that in 3-5 years old children (26.6%, 213/801) and that under 3 years old children (18.3%, 270/1480). The difference showed statistical significance (χ(2) = 187.432, P < 0.01). A total of 219 (7.7%) cases were positive for RSV,including 108 RSV-A positive samples and 112 RSV-B positive samples (1 co-infection). The epidemic of RSV showed an obvious seasonal pattern with peaks in autumn,winter and spring,which accounted for 96.8% (212/219) of all the cases; however, the annual incidence of RSV fluctuated greatly. The predominant subtype shifted every 2 years. RSV-B predominated during September 2008 and May 2009, December 2009 and March 2010, accounting for 76.6% (36/47) and 96.9% (62/64) respectively. RSV-A predominated during November 2010 and March 2011, September 2011 and April 2012, accounting for 92.5% (37/40) and 100.0% (48/48) respectively. With the increase of the age, the positive rate of RSV-A and RSV-B decreased gradually (RSV-A: χ(2) = 36.223, P < 0.01; RSV-B: χ(2) = 36.281, P < 0.01). The positive rates of RSV-A in children < 1,1,2,3,4,5-9 and 10-14 years old were 7.0% (26/373), 5.9% (39/662), 4.0% (18/445), 3.2% (13/406), 1.3% (3/236), 1.4% (7/517) and 0.9% (2/215) respectively; while, the positive rates of RSV-B in each age group were 6.4% (24/373), 6.0% (40/662), 4.5% (20/445), 4.4% (18/406), 1.3% (3/236), 1.0% (5/517) and 0.9% (2/215) respectively. The children aged 0-3 years old were more susceptible for RSV infection,accounting for 90.0% (197/219) of the total positive samples. During the outbreak of influenza A H1N1 in November 2009, the positive rate of RSW was 3.0% (3/100), lower than that in the same month of 2008, 2010 and 2011,which were separately 18.2% (6/33), 10.8% (10/93) and 10.0% (4/40). The difference showed statistical significance (χ(2) = 8.450, P < 0.05). During the outbreak of influenza A (H1N1) in January 2011,the positive rate of RSV was 5.7% (3/53), lower than those in the same month of 2009, 2010 and 2012, which was separately 21.7% (5/23), 28.6% (22/77) and 16.0% (8/50). The difference showed statistical significance (χ(2) = 11.233,P < 0.05). During the period of less influenza happened in September 2011, the RSV positive rate was 25.0% (10/40), higher than those in the same month of 2008, 2009 and 2010, which was separately 11.4% (4/35), 1.7% (2/118) and 0.0% (0/109). The difference showed statistical significance (χ(2) = 32.521, P < 0.01).Both influenza virus and RSV were important etiological agents of ILI of children in Wuhan. The characteristics of seasonal and age distributions of the two viruses were notably different; meanwhile, a certain inhibitional effect of influenza virus on RSV could be observed.",
        "keywords": [],
        "authors": [
            {
                "name": "Ying Wang",
                "org": "Virus Laboratory, Wuhan Center for Disease Control and Prevention, Wuhan, China."
            },
            {
                "name": "Yu Zhang",
                "org": ""
            },
            {
                "name": "Wen-hua Kong",
                "org": ""
            },
            {
                "name": "Hong-hao Zhu",
                "org": ""
            },
            {
                "name": "Xin-ming Lin",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Quan Hu",
                "org": ""
            },
            {
                "name": "Xiao-ping Miao",
                "org": ""
            },
            {
                "name": "De-yin Guo",
                "org": ""
            },
            {
                "name": "Jin-song Peng",
                "org": ""
            }
        ],
        "venue": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
        "year": 2013
    },
    "FxJ8M4QL": {
        "id": "FxJ8M4QL",
        "title": "Analysis on epidemiological features of Hepatitis A and Hepatitis E in Wuhan City from 2004 to 2009",
        "abstract": "Objective To analyze the incidence and epidemiological trend of hepatitis A and hepatitis E viral in Wuhan City from 2004 to 2009.Methods Descriptive epidemiological study was conducted.Statistical methods including Chi-Square test,Pearson contingency coefficient and concentration ratio were used.Results 1 376 cases of Hepatitis A and 4 044 cases of Hepatitis E were reported in Wuhan City from 2004 to 2009. The average incidences of them were 2.81 per 100 000 and 8.25 per 100 000 respectively.Incidence of Hepatitis A was low,which was high with Hepatitis E,and they both had a downward trend.Annual distribution of cases of Hepatitis A and Hepatitis E had no obvious seasonal fluctuations.The average incidence of Hepatitis A was lower in urban than in rural and of Hepatitis E was higher in urban than in rural(P<0.001),which rose gradually by age(Hepatitis A: χ2=282.85,P<0.001,r=0.28,P<0.001;Hepatitis E: χ2=320.37,P<0.001,r=0.30,P<0.001) and were the highest from 50 to 79 year old,and which were higher in male than in female(P<0.001).Among the total cases,farmers accounted for 31.32 percent of Hepatitis A and retirees accounted for 29.35 percent of Hepatitis E.Conclusions In recent years,the incidence of Hepatitis A was low,having a declining trend,which was higher in rural,the incidence of Hepatitis E was high,having a declining trend,which was higher in urban,the key population of Hepatitis A and Hepatitis E were males and the people aged over fifty.",
        "keywords": [
            "Hepatitis A virus",
            "Incidence",
            "Hepatitis E virus",
            "Epidemiologic studies"
        ],
        "authors": [
            {
                "name": "KONG De-guang",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "LUO Tong-yong",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "YU Bin",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "HU Quan",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "LI Qiu-ling",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "DU Hong",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            },
            {
                "name": "WANG Yong-hong",
                "org": ".Institute of Communicable Disease,Wuhan Center for Disease Control and Prevention,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Disease Control & Prevention",
        "year": 2011
    },
    "Q3HVneKJ": {
        "id": "Q3HVneKJ",
        "title": "Surveillance and drug resistance of Bacterial Dysentery in Wuhan city(2006-2007)",
        "abstract": "Objective To have a better understanding of the predominant strains of shigella causing dysentery and their sensitivity to different drugs in Wuhan,so as to provide suggestion for shigellosis prevention and rational prescriptions.Methods A systematic surveillance and detection according to the<Nation Project for Surveillance on Bacterial Dysentery>was made.Results Of the 539 samples from the patients,17 samples were identified to be positive,3.2%,including 15 strains of Sh.Sonnet and 2 strains of Sh.Flexneri,88.2% and 11.8% respectively.Drug sensitivity tests revealed that all shigella were sensitive to ampicillin(100%),ciprofloxacin(100%),and all were resistant to rifampicin(100%),5 samples were even multiple-resistant.Conclusion The prevailing pathogenic bacteria of bacterial dysentery were Sh.Sonne in Wuhan city from 2006 to 2007,the second were Sh.Flexneri,all of them showed resistant to commonly-used antibiotics,thus,special attentioned should be paid.",
        "keywords": [
            "Bacterial Dysentery",
            "Shigella",
            "Susceptibility",
            "Surveillance"
        ],
        "authors": [
            {
                "name": "HU Quan",
                "org": ". Wuhan Centers for Disease and Prevention Control,WuHan ,China"
            },
            {
                "name": "XIONG Yan",
                "org": ". Wuhan Centers for Disease and Prevention Control,WuHan ,China"
            },
            {
                "name": "CHEN Bang-hua",
                "org": ". Wuhan Centers for Disease and Prevention Control,WuHan ,China"
            },
            {
                "name": "YU bin",
                "org": ". Wuhan Centers for Disease and Prevention Control,WuHan ,China"
            },
            {
                "name": "CHEN Jian",
                "org": ". Wuhan Centers for Disease and Prevention Control,WuHan ,China"
            },
            {
                "name": "DU hong",
                "org": ". Wuhan Centers for Disease and Prevention Control,WuHan ,China"
            }
        ],
        "venue": "Journal of Public Health and Preventive Medicine",
        "year": 2008
    },
    "BBD6lVnL": {
        "id": "BBD6lVnL",
        "title": "Epidemiological Survey on Vaccination Rate of Neonatal Hepatitis B Vaccine and Carrier Rate of Maternal Hepatitis B Virus in 2003 in Wuhan City",
        "abstract": "Objective The present study was designed to understand the initial vaccination rate of the neonatal anti-hepatitis B vaccine, the whole range vaccination rate and the infection rate of maternal hepatitis B virus in Wuhan city. Methods Delivery rooms of all hospitals and planned immunization sites in the city were investigated and statistically analyzed using Microsoft Excel 2000. Results The initial immunization rate of the neonatal hepatitis B vaccine was 98.51% , with a timely rate of 95.32%. The urban areas were better than the suburbs in the aspects. The rate of full-course immunization was 86.87%, the suburbs better than the urban areas, and permanent population better than floating population. The screening rate of hepatitis B of postnatal women in the whole city was 66.29 and the carrier rate 6.04%. The anti-hepatitis B immunoglobulin rate of the neonatals whose mothers carried HBV was 84.24%. And the urban areas was better than the suburbs in hepatitis B screening and the neonatal anti-hepatitis B immunoglobulin immunization. Conclusion The initial immunization rate and the timely rate have been encouraging since the implementation of free immunization of neonatal hepatitis B vaccine in the whole city, but the full-course rate is less satisfying. There exists a weakness in the planned immunization, and particularly the difficulty in the management of floating population in the urban areas interferes with planned immunization substantially. The immunization of hepatitis B vaccine in adolescent should be covered in the immunization programme.",
        "keywords": [
            "Maternal carrier rate of hepatitis B virus",
            "Planned immunization",
            "Immunization rate of hepatitis B vaccine"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ". Wuhan Municipal CDC , Jiang`an ,China"
            },
            {
                "name": "ZHOU Dun-jin",
                "org": ". Wuhan Municipal CDC , Jiang`an ,China"
            },
            {
                "name": "XIA Jun-nan",
                "org": ". Wuhan Municipal CDC , Jiang`an ,China"
            },
            {
                "name": "LUO Tong-yong",
                "org": ". Wuhan Municipal CDC , Jiang`an ,China"
            },
            {
                "name": "CHEN Jian",
                "org": ". Wuhan Municipal CDC , Jiang`an ,China"
            },
            {
                "name": "LIU Pu-lin",
                "org": ". Wuhan Municipal CDC , Jiang`an ,China"
            }
        ],
        "venue": "Disease Surveillance",
        "year": 2005
    },
    "Sw3Vb4Qr": {
        "id": "Sw3Vb4Qr",
        "title": "Structure Superimposed Halo Model of Deep Blind Ore Forecast for the Quartz Vein-Altered Rock Type Gold Deposits in East Shandong Province",
        "abstract": "Based on the study of typical quartz vein type and structural superimposed halo model of blind ore prediction in deep altered rock type gold deposits of Shandong Province,the summarize of its common,we built the ideal structure superimposed halo model of quartz vein and altered rock type,determined five guidelines of blind ore forecast structural superimposed halo.During the prediction,we conducted the follow-up study of multiple gold targets,summaried the reasons of not see mine targets according to projections,revised and improved the forecasting models and the predict sign of blind mine,the forecast was continuously pushed forward into deep deposit.The method of looking for blind ore by structural superimposed halo achieved a new breakthrough both in the theory and methods technical research,not only improved the theory of the method,but also made the techniques more mature.There was a significant prospecting effect by using the method to forecast blind mine in deep deposits.",
        "keywords": [
            "Structural superposition halo model",
            "Eastern Shandong",
            "Prediction of deep blind ore",
            "Quartz vein-altered rock type gold deposits"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "YU Bin",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LI Deliang",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "MA Jiuju",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "WEI Jiang",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "ZHAO Jiaxiang",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "SUN Fengzhou",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "ZHAI Pei",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "WANG Jun",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "WANG Xiao",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LI Shang",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "ZHANG Heran",
                "org": " Geophysical Exploration Academy of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            }
        ],
        "venue": "Gold Science and Technology",
        "year": 2012
    },
    "xwhQF5WU": {
        "id": "xwhQF5WU",
        "title": "METHOD OF STRUCTURAL OVERPRINTING GEOCHEMICAL HALO,A NEW AND EFFECTIVE APPROACH TO PROSPECTING FOR SUCCEEDING RESOURCES IN GOLD DEPOSITS WITH RESOURCES CRISIS",
        "abstract": "The method of structural overprinting geochemical halo based on zonation primary halo is one of the new approaches for forecasting of hidden ore body. This approach has been applied to the vicinities and depth of gold mine and excellent effects are obtained.",
        "keywords": [
            "structural overprinting geochemical halo",
            "excellent effect",
            "hidden ore forecasting"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Geophysical Exploration Institute,China Exploration & Engineering Bureau,Baoding "
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Geophysical Exploration Institute,China Exploration & Engineering Bureau,Baoding "
            },
            {
                "name": "YU Bin",
                "org": "Geophysical Exploration Institute,China Exploration & Engineering Bureau,Baoding "
            },
            {
                "name": "ZHANG Lian-fa",
                "org": "Geophysical Exploration Institute,China Exploration & Engineering Bureau,Baoding "
            },
            {
                "name": "WANG Zhi-nong",
                "org": "China Institute for Geo-environmental Monitoring,Beijing "
            },
            {
                "name": "LI De-liang",
                "org": "Geophysical Exploration Institute,China Exploration & Engineering Bureau,Baoding "
            },
            {
                "name": "WANG Zhi-yuan",
                "org": "Geophysical Exploration Institute,China Exploration & Engineering Bureau,Baoding "
            }
        ],
        "venue": "Mineral Resources and Geology",
        "year": 2005
    },
    "WcuECNQC": {
        "id": "WcuECNQC",
        "title": "Prediction of Blind Ore Bodies Using Structural Superimposed Halo and Research Methods",
        "abstract": "The new method of structural superimposed halo has been applied to more than 50 mines to predict blind ore bodies, and has received ideal results. This paper presents the concept of structural superimposed halo, research idea, content, procedure and key techniques for predicting blind orebodies in several typical gold mines. The work includes the arrangement of field surveys, special sampling methods, required geochemical parameters and pictures, requirements of modeling as well as the delineating methods of blind ore-body targets. Mastering this technique of structural superimposed halo can help construct good prediction models with high accuracy, which will be utilized to prospect the deep and adjacent areas efficiently.",
        "keywords": [
            "structural superimposed halo",
            "ore body prediction",
            "new method",
            "research method"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "YU Bin",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "LI De-liang",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "MA Jiu-ju",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "ZHANG Qiang",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "SUN Feng-zhou",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "LI Shang",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "WEI Jiang",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "ZHAO Jia-xiang",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "WANG Jun",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            },
            {
                "name": "ZHAI Pei",
                "org": "Geophysical Exploration Bureau of CMGB, Baoding,Hebei "
            }
        ],
        "venue": "Geology and Exploration",
        "year": 2013
    },
    "shbjB3wj": {
        "id": "shbjB3wj",
        "title": "A NEW PROGNOSTIC METHOD USING STRUCTURE SUPERIMPOSED HALO IN REGIONAL METALLOGENIC BELT",
        "abstract": "The authors summarized the basis and foundation of the prospecting prognostic method based on structural superimposed halo of the metallogenic belt.With the Rushan gold metallogenic belt in Shandong as the demonstration prognostic area,the authors put forward the new train of thought,working contents and flow chart for metallogenic prognosis based on structure superimposed halo in the metallogenic belt.The successful prediction results of Rushan show that the structure superimposed halo prediction is a direct,fast and effective way in regional metallogenic prognosis.",
        "keywords": [
            "ore prognosis",
            "method of structural superimposed halo",
            "regional metallogenic belt of gold"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "YU Bin",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "LI De-liang",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "MA Jiu-ju",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "SUN Feng-zhou",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "LI Shang",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "WEI Jiang",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "ZHAO Jia-xiang",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "WANG Jun",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "ZHAI Pei",
                "org": "Geophysical Exploration Bureau of CMGB,Baoding ,China"
            }
        ],
        "venue": "Geophysical and Geochemical Exploration",
        "year": 2013
    },
    "JqYuGTDt": {
        "id": "JqYuGTDt",
        "title": "Summary of new methods on deep prediction of geochemical exploration",
        "abstract": "This paper proposes optimal methods of geochemical exploration on prediction of deep blind ore body and optimal method combination at different conditions on the base of summarizing new methods and new techniques developed in the world during previous twenty years and showing their characteristics,validity and application conditions.",
        "keywords": [
            "summary",
            "new geochemical exploration method",
            "optimal method",
            "deep prediction"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "YU Bin",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "LI De-liang",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "MA Jiu-ju",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "XU Li-yun",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "WEI Jiang",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "ZHAO Jia-xiang",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "ZHANG Qiang",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "SI Shu-yun",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "YANG Ya-juan",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            },
            {
                "name": "HE Rong-hua",
                "org": "Institute of Geophysical Exploration,China Metallurgical Geology Bureau,Baoding "
            }
        ],
        "venue": "Mineral Exploration",
        "year": 2010
    },
    "59fe3Osq": {
        "id": "59fe3Osq",
        "title": "NEW GEOCHEMICAL METHODS AND BEST TECHNIQUE COMBINATION FOR PREDICTION OF BLIND OREBODY IN THE DEEP AND SURROUNDING OF CRISIS MINES",
        "abstract": "This paper summarized new geochemical methods and techniques for prediction of blind or concealed ore-bodies from China and abroad,and discoursed on their properties,efficiency and applying condition in the prediction.The best geochemical method and best technique combination at different conditions are suggested for the prediction of blind orebodies in the deep and surrounding of crisis mines.",
        "keywords": [
            "prediction of blind or concealed orebody",
            "deep and surrounding of mine",
            "composition of method",
            "best geochemical way"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Geophysical Exploration Bureau,CEEB,Baoding "
            },
            {
                "name": "CEN Kuang",
                "org": "China University of Geosciences,Beijing "
            },
            {
                "name": "SHEN Yong-li",
                "org": "China University of Geosciences,Beijing "
            },
            {
                "name": "WU Yue-bin",
                "org": "China University of Geosciences,Beijing "
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Geophysical Exploration Bureau,CEEB,Baoding "
            },
            {
                "name": "ZHANG Lian-fa",
                "org": "Geophysical Exploration Bureau,CEEB,Baoding "
            },
            {
                "name": "YU Bin",
                "org": "Geophysical Exploration Bureau,CEEB,Baoding "
            }
        ],
        "venue": "Geology and Prospecting",
        "year": 2006
    },
    "xFRRobsW": {
        "id": "xFRRobsW",
        "title": "THE 20~(TH) CENTURY'S 10 NEW ACHIEVEMENTS IN THE METALLURGICAL GEOLOGY FIELD",
        "abstract": "The paper introduces 10 new achievements made in metallurgical geological field during the 20th century and the results of their application to ore exploration.They are: model of structural overprint halo for blind ore bodies,Hg vapor survey and heat-released Hg survey for blind ore bodies,research on geochemical anomaly model of typical non-ferrous metal deposits,research on gold ore-searching geochemical model of major gold deposit types in China,the primary geochemical expert system for blind gold ore body prediction in gold ore bodies of Jiaodong area,the new methods of fluid inclusion gas halo,ion halo and their overprint halo for gold ore-searching,\"three ring and one cap\" geochemical anomaly model of W ore veins,the new method of determining halogen and heat-released halogen for blind ore bodies,establishment of fine quality Mn ore-searching geochemical anomaly model,ore belts and districts geochemical survey for precious or non-ferrous metal mineral resources.",
        "keywords": [
            "metallurgical geology",
            "geochemical exploration",
            "new achievement"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Geophysial and Geochemical Exploration Institute of China Geo-exploration & Engineering General Bureau,Baoding ,China"
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Geophysial and Geochemical Exploration Institute of China Geo-exploration & Engineering General Bureau,Baoding ,China"
            },
            {
                "name": "YU Bin",
                "org": "Geophysial and Geochemical Exploration Institute of China Geo-exploration & Engineering General Bureau,Baoding ,China"
            },
            {
                "name": "LI De-liang",
                "org": "Geophysial and Geochemical Exploration Institute of China Geo-exploration & Engineering General Bureau,Baoding ,China"
            }
        ],
        "venue": "Contributions to Geology and Mineral Resources Research",
        "year": 2006
    },
    "uMIjWsWG": {
        "id": "uMIjWsWG",
        "title": "THE STRUCTURAL SUPERIMPOSED HALO MODEL FOR THE DIAOQUAN SKARN SILVER-COPPER DEPOSIT IN LINGQIU COUNTY,SHANXI PROVINCE",
        "abstract": "Based on a study of characteristics of element associations and structural superimposed halos at different ore-forming stages of the Diaoquan skarn silver-copper deposit in Lingqiu County of Shanxi Province,the authors established a structural superimposed halo model for prognosis of blind ore bodies at the depth of the ore deposit.The prognostic results show that this model is very effective in search for blind ore bodies.",
        "keywords": [
            "skarn silver-copper deposit",
            "structural superimposed halo model",
            "Diaoquan in Shanxi Province",
            "geochemistry"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            },
            {
                "name": "LI De-liang",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            },
            {
                "name": "YU Bin",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            },
            {
                "name": "WANG Zhi-yuan",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            },
            {
                "name": "XU Li-yun",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            },
            {
                "name": "CHEN Jian-fei",
                "org": "Academy of Geophysical Exploration,China Administration of Metallurgical Geology,Baoding 1,China"
            }
        ],
        "venue": "Geophysical and Geochemical Exploration",
        "year": 2008
    },
    "mKnnIh32": {
        "id": "mKnnIh32",
        "title": "The Structural Superimposed Halos'S Study and Deep Predicition of Jinniu Mountain Gold Deposit Muping-Shandong",
        "abstract": "The authors has studied the structural superimposed halos's features of jinniu mountain gold deposit,Established the model and marks of structural superimposed halos of the blind ore predicition,then make blind ore prediction in the deposit deeps,take out blind ore targets,and obtain good result by using the model,and marks.",
        "keywords": [
            "structural superimposed halos",
            "jinniu mountain gold deposit.",
            "deep predicition"
        ],
        "authors": [
            {
                "name": "TANG Junzhi",
                "org": "Shandong Humon Melt Stock Ltd,Yantai ,China"
            },
            {
                "name": "WANG Xueqian",
                "org": "Shandong Humon Melt Stock Ltd,Yantai ,China"
            },
            {
                "name": "WANG Zhiping",
                "org": "Shandong Humon Melt Stock Ltd,Yantai ,China"
            },
            {
                "name": "LI Hui",
                "org": "Geophsical Exploratian Bureau of CEEB,Baoding ,China"
            },
            {
                "name": "LI Deliang",
                "org": "Geophsical Exploratian Bureau of CEEB,Baoding ,China"
            },
            {
                "name": "YU Bin",
                "org": "Geophsical Exploratian Bureau of CEEB,Baoding ,China"
            }
        ],
        "venue": "Gold Science and Technology",
        "year": 2007
    },
    "1D9MqXoG": {
        "id": "1D9MqXoG",
        "title": "The Application of New Stuctural Superimposed Halo Method in Deep Blind Ore Prediction of Xiaoqinling Gold Metallogenic Belt",
        "abstract": "We analyze the structure superimposed halo characteristics of Xiaoqinling gold deposit,and establish model of deep blind ore prediction of typical gold deposits,achieve good results of searching blind ore.Through summarize the common of typical deposit,we establish structure superimposed halo model of deep blind ore in Xiaoqinling gold metallogenic belt.",
        "keywords": [
            "Xiaoqinling gold metallogenic belt",
            "Deep blind ore prediction",
            "Model of structural superimpose halo"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Geophysical Exploration Institute,China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LI Deliang",
                "org": "Geophysical Exploration Institute,China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "YU Bin",
                "org": "Geophysical Exploration Institute,China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "ZHAO Jiaxiang",
                "org": "Geophysical Exploration Institute,China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "CHEN Xiaomin",
                "org": "Qinling Gold Mine,Lingbao ,Henan,China"
            },
            {
                "name": "LI Qingyun",
                "org": "Qinling Gold Mine,Lingbao ,Henan,China"
            },
            {
                "name": "ZHAO Zongqin",
                "org": "Dongtongyu Gold Mine,Tongguan ,Shaanxi,China"
            },
            {
                "name": "LIANG Binxiang",
                "org": "Dongtongyu Gold Mine,Tongguan ,Shaanxi,China"
            }
        ],
        "venue": "Gold Science and Technology",
        "year": 2010
    },
    "zHOIVh1o": {
        "id": "zHOIVh1o",
        "title": "STRUCTURAL OVERPRINT HALO MODEL OF THE PREDICTED BLIND ORE BODIES OF BAIYUN GOLD DEPOSIT,FENGCHENG COUNTY,LIAONING PROVINCE AND THE PREDICTION RESULT",
        "abstract": "The structural overprint halo technique is applied to set up the model of the overprint halo in Baiyun gold deposit.The model was used as the guide to predict blind ore bodies at depth.7 targets and 2 potential area were located by the prediction.Drill operated at several targets hit ore bodies which are calculated to reserve about 10.6t Au and the former medium sized Baiyun Au deposit becomes a lange sized one now and the Life time of the mine etends 10 years more.",
        "keywords": [
            "Liaoning province",
            "Structural overprint model",
            "Baiyun Au deposit",
            "blind ore body prediction to depth"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": " Geophy sical Exploration Institute of China Metallurgical Geo-exploration Bureau,Baoding ,Hebeiprovince,China"
            },
            {
                "name": "LI De-liang",
                "org": " Geophy sical Exploration Institute of China Metallurgical Geo-exploration Bureau,Baoding ,Hebeiprovince,China"
            },
            {
                "name": "YU Bin",
                "org": " Geophy sical Exploration Institute of China Metallurgical Geo-exploration Bureau,Baoding ,Hebeiprovince,China"
            },
            {
                "name": "WEI Jiang",
                "org": " Geophy sical Exploration Institute of China Metallurgical Geo-exploration Bureau,Baoding ,Hebeiprovince,China"
            },
            {
                "name": "HE Rong-Hua",
                "org": " Geophy sical Exploration Institute of China Metallurgical Geo-exploration Bureau,Baoding ,Hebeiprovince,China"
            },
            {
                "name": "ZHOU Chuan-qin",
                "org": " Fengcheng Gold Group Ltd.,Fengcheng ,Liaoning province,Chia"
            },
            {
                "name": "LIU Heng-gang",
                "org": " Fengcheng Gold Group Ltd.,Fengcheng ,Liaoning province,Chia"
            },
            {
                "name": "CHEN He",
                "org": " Fengcheng Gold Group Ltd.,Fengcheng ,Liaoning province,Chia"
            },
            {
                "name": "LANG Fu-quan",
                "org": " Fengcheng Gold Group Ltd.,Fengcheng ,Liaoning province,Chia"
            },
            {
                "name": "DU Han-chun",
                "org": " Fengcheng Gold Group Ltd.,Fengcheng ,Liaoning province,Chia"
            },
            {
                "name": "QI En-bo",
                "org": " Fengcheng Gold Group Ltd.,Fengcheng ,Liaoning province,Chia"
            }
        ],
        "venue": "Contributions to Geology and Mineral Resources Research",
        "year": 2010
    },
    "u0t0bgJW": {
        "id": "u0t0bgJW",
        "title": "THE STRUCTURAL SUPERIMPOSED HALO MODEL FOR PROGNOSIS OF No.2 ENRICHMENT ZONE AT THE DEPTH OF THE XIAO QINLING GOLD ORE CONCENTRATION AREA",
        "abstract": "This paper has dealt with the common features of three superlarge typical quartz-vein type gold ore deposits(Wenyu,Qinling and Dongtongyu) in Xiao Qinling region,established the ideal structural superimposed halo model for prognosis in No.2 enrichment zone at the depth of Xiao Qinling quartz vein type gold ore deposits,and determined the prognostic criteria for blind deposits in the ore district.As a result,satisfactory ore-prospecting results were obtained.",
        "keywords": [
            "deep prognostic model",
            "structural superimposed halo",
            "Xiao Qinling",
            "gold deposit"
        ],
        "authors": [
            {
                "name": "LI Hui",
                "org": "Institute of Geophysical and Geochemical Exploration,Academy of Geophysical Exploration of China Headquarters of Metallurgy and Exploration,Baoding ,China"
            },
            {
                "name": "ZHANG Guo-yi",
                "org": "Institute of Geophysical and Geochemical Exploration,Academy of Geophysical Exploration of China Headquarters of Metallurgy and Exploration,Baoding ,China"
            },
            {
                "name": "GAO Yan-long",
                "org": "Qinling Gold Mine of Henan,Lingbao ,China"
            },
            {
                "name": "ZHAO Zong-qin",
                "org": "Dongtongyu Gold Mine,Tongguan ,China"
            },
            {
                "name": "LI De-liang",
                "org": "Institute of Geophysical and Geochemical Exploration,Academy of Geophysical Exploration of China Headquarters of Metallurgy and Exploration,Baoding ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Geophysical and Geochemical Exploration,Academy of Geophysical Exploration of China Headquarters of Metallurgy and Exploration,Baoding ,China"
            },
            {
                "name": "SHAO Jian-bo",
                "org": "Dongtongyu Gold Mine,Tongguan ,China"
            },
            {
                "name": "GUO Chao-yan",
                "org": "Qinling Gold Mine of Henan,Lingbao ,China"
            }
        ],
        "venue": "Geophysical and Geochemical Exploration",
        "year": 2008
    },
    "zJZgDwDb": {
        "id": "zJZgDwDb",
        "title": "Structural superimposed halos method for prospecting blind ore-body in the deep of ore-districts",
        "abstract": "The method of structural superimposed halos is developed on the theory of prospecting blind ore by primary halos. Based on the facts that the formation of halos and ore-bodies in a hydrothermal deposit is rigorously controlled by tectonic structures and it shows a feature of superposition of multi-forming period and multi-forming stage,we developed the theory of superimposed primary halos,and solved the puzzles of appearance of abnormal bandings in the research of axial banding of primary halos for geochemists in decades,and proposed originally the new method of structural superimposed halos for blind ore prospecting. This paper introduced the features of structural superimposed halos and the main achievements in blind ore-body prospecting,and four ideal models of superimposed frames for gold districts and five guidelines in the prognosis of blind ore-bodies,as well as the successful examples in gold regions.",
        "keywords": [
            "the deep of ore-district",
            "prognosis of blind ore-body",
            "new method of structural superimposed halo",
            "achievement in blind ore-body prospecting"
        ],
        "authors": [
            {
                "name": "Li Hui",
                "org": " Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "Zhang Guoyi",
                "org": " Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "Yu Bin",
                "org": " Geophysical Exploration Bureau of CMGB,Baoding ,China"
            },
            {
                "name": "Li Deliang",
                "org": " Geophysical Exploration Bureau of CMGB,Baoding ,China"
            }
        ],
        "venue": "Earth Science Frontiers",
        "year": 2010
    },
    "ws018otG": {
        "id": "ws018otG",
        "title": "THE STRUCTURAL SUPERIMPOSED HALO MODEL RESEARCH AND DEEP ORE FORECAST FOR SANSHANDAO GOLD DEPOSIT,SHANDONG LAIZHOU",
        "abstract": "Based on geochemical background,geochemical and structurally imposed halo characteristics of Sanshandao gold deposit the structurally superimposed halo model of Au ore body in the deposit is established and criteria for the blind ore prediction determined.The model is used to predict blind ore and 4 targets are put forward.Gold ore is hit at some targets and result of the prediction is good.",
        "keywords": [
            "Sanshandao gold deposit",
            "model",
            "the structurally superimposed halo"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Geophysical Survey of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LI Hui",
                "org": "Institute of Geophysical Survey of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LI De-liang",
                "org": "Institute of Geophysical Survey of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "ZHANG Lian-fa",
                "org": "Institute of Geophysical Survey of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LIU Qing",
                "org": "Institute of Geophysical Survey of China Metallurgical Geology Bureau,Baoding ,Hebei,China"
            },
            {
                "name": "LI Wei",
                "org": "Sanshandao Gold Mine of Shandong Gold Group Co.LTD,Laizhou ,Shangdong,China"
            },
            {
                "name": "WANG Shan-fei",
                "org": "Sanshandao Gold Mine of Shandong Gold Group Co.LTD,Laizhou ,Shangdong,China"
            },
            {
                "name": "LI Si-ling",
                "org": "Sanshandao Gold Mine of Shandong Gold Group Co.LTD,Laizhou ,Shangdong,China"
            },
            {
                "name": "YANG Qing-quan",
                "org": "Sanshandao Gold Mine of Shandong Gold Group Co.LTD,Laizhou ,Shangdong,China"
            },
            {
                "name": "GUO Bin",
                "org": "Sanshandao Gold Mine of Shandong Gold Group Co.LTD,Laizhou ,Shangdong,China"
            },
            {
                "name": "QU Wei-xun",
                "org": "Sanshandao Gold Mine of Shandong Gold Group Co.LTD,Laizhou ,Shangdong,China"
            },
            {
                "name": "ZHAO Dong-dong",
                "org": "The 3rd Branch of The Shangdong China Metallurgical Geology Bureau,Yantai ,Shandong,China"
            }
        ],
        "venue": "Contributions to Geology and Mineral Resources Research",
        "year": 2010
    },
    "8mgHmYC7": {
        "id": "8mgHmYC7",
        "title": "The Application and Effect of SAS Statistical Software in Geochemical Prospecting Field",
        "abstract": "Discrimination analysis is a common statistical method in the geological exploration field.Normally we i-dentify the properties of unknown geological object by mul-tivariate discrimination function.Now we take an example to introduce the application of the SAS statistical software in the geochemical prospecting field.There are several proper-ties of it such as high practical application,good functions,easy to be mastered and learned.",
        "keywords": [
            "discrimination function",
            "model",
            "SAS",
            "prospecting",
            "discrimination analysis"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "China Metallurgical And Geological BUREAU Geophysical Exploration Institute,Hebei Baoding ,China"
            },
            {
                "name": "SI Shu-Yun",
                "org": "China Metallurgical And Geological BUREAU Geophysical Exploration Institute,Hebei Baoding ,China"
            },
            {
                "name": "LI De-Liang",
                "org": "China Metallurgical And Geological BUREAU Geophysical Exploration Institute,Hebei Baoding ,China"
            }
        ],
        "venue": "Journal of Hebei Software Institute",
        "year": 2008
    },
    "C6oFpXIY": {
        "id": "C6oFpXIY",
        "title": "Improvement in quality of life in patients with nasopharyngeal carcinoma treated with non-invasive extracorporeal radiofrequency in combination with chemoradiotherapy.",
        "abstract": "To improve the quality of life (QOL) of patients with nasopharyngeal carcinoma (NPC) after chemoradiotherapy (CRT), it is necessary to find an effective method to reduce the toxic side-effects of CRT.Between June 2007 and June 2010, 83 previously untreated patients with NPC were randomized to receive CRT either with or without non-invasive extracorporeal radiofrequency (ERF). All the patients underwent radiation, and weekly chemotherapy of paclitaxel 135-175 mg/m(2) and cisplatin 60-90 mg/m(2). In addition, the patients in the treatment group also underwent non-invasive ERF on a radiofrequency machine at 13.56 MHz for 1 hour at 41-43°C. After the completion of treatment, evaluation was carried out to determine the survival rate, disease-free survival time, and QOL. QOL was analyzed by using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Cancer Module (EORTC QLQ-H&N35) every 6 months during the three-year period.After completion of the treatments, the 36-month survival rate was 0.730 in the treatment group and 0.535 in the reference group (p = 0.041); the average disease-free survival time was 48 months in the treatment group and only 37.5 months in the reference group (p = 0.048). In the post- treatment questionnaires, several NPC-specific (pain, swallowing, speech, social eating, opening mouth, dry mouth, sticky saliva) QOL domains were better preserved with CRT + ERF compared to CRT at different time-points.The combination treatment of ERF with CRT can prolong the survival rate and disease-free survival time and improve the QOL for patients with NPC.",
        "keywords": [
            "nasopharyngeal carcinoma (npc)",
            "non-invasive extracorporeal radiofrequency (erf)",
            "quality of life (qol)"
        ],
        "authors": [
            {
                "name": "Changlin Zhao",
                "org": "Department of Traditional Chinese Medicine, School of Medicine, Jinan University , Guangzhou."
            },
            {
                "name": "Jia Chen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Xiaoyin Chen",
                "org": ""
            }
        ],
        "venue": "International journal of radiation biology",
        "year": 2014
    },
    "5m323pEp": {
        "id": "5m323pEp",
        "title": "Andrographolide as an anti-H1N1 drug and the mechanism related to retinoic acid-inducible gene-I-like receptors signaling pathway.",
        "abstract": "To observe the anti-virus effects of andrographolide (AD) on the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) signaling pathway when immunological cells were infected with H1N1.Leukomonocyte was obtained from umbilical cord blood by Ficoll density gradient centrifugation, and immunological cells were harvested after cytokines stimulation. Virus infected cell model was established by H1N1 co-cultured with normal human bronchial epithelial cell line (16HBE). The optimal concentration of AD was defined by methyl-thiazolyl-tetrazolium (MTT) assay. After the virus infected cell model was established, AD was added into the medium as a treatment intervention. After 24-h co-culture, cell supernatant was collected for interferon gamma (IFN-γ) and interleukin-4 (IL-4) enzyme-linked immunosorbent assay (ELISA) detection while immunological cells for real-time polymerase chain reaction (RT-PCR).The optimal concentration of AD for anti-virus effect was 250 μg/mL. IL-4 and IFN-γ in the supernatant and mRNA levels in RLRs pathway increased when cells was infected by virus, RIG-I, IFN-β promoter stimulator-1 (IPS-1), interferon regulatory factor (IRF)-7, IRF-3 and nuclear transcription factor κB (NF-κB) mRNA levels increased significantly (P<0.05). When AD was added into co-culture medium, the levels of IL-4 and IFN-γ were lower than those in the non-interference groups and the mRNA expression levels decreased, RIG-I, IPS-1, IRF-7, IRF-3 and NF-κB decreased significantly in each group with significant statistic differences (P<0.05).The RLRs mediated viral recognition provided a potential molecular target for acute viral infections and andrographolide could ameliorate H1N1 virus-induced cell mortality. And the antiviral effects might be related to its inhibition of viral-induced activation of the RLRs signaling pathway.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Traditional Chinese Medicine, School of Medicine, Jinan University, Guangzhou, 510632, China."
            },
            {
                "name": "Cong-qi Dai",
                "org": ""
            },
            {
                "name": "Zhen-you Jiang",
                "org": ""
            },
            {
                "name": "En-qing Li",
                "org": ""
            },
            {
                "name": "Chen Chen",
                "org": ""
            },
            {
                "name": "Xian-lin Wu",
                "org": ""
            },
            {
                "name": "Jia Chen",
                "org": ""
            },
            {
                "name": "Qian Liu",
                "org": ""
            },
            {
                "name": "Chang-lin Zhao",
                "org": ""
            },
            {
                "name": "Jin-xiong He",
                "org": ""
            },
            {
                "name": "Da-hong Ju",
                "org": ""
            },
            {
                "name": "Xiao-yin Chen",
                "org": ""
            }
        ],
        "venue": "Chinese journal of integrative medicine",
        "year": 2014
    },
    "AcxlrLdt": {
        "id": "AcxlrLdt",
        "title": "Effect of Shengmai San on the on the Rats of Diabetic Cardiomyopathy",
        "abstract": "Objective:Observe the effect of Shengmai San on the diabetic cardiomyopathy(DCM).Methods:The rat model of DCM was established by eating a high-fat diet together with injection of high dose streptozotocin(50mg/kg) intraperitoneally.After 12 weeks,electrocardiogram was used to evaluate the damage of the myocardial,blood serum GLU,cholesterin and TG were tested by Clinical Chemistry Test Systems.The content of collagen was quantified by Masson staining.Level of cardiomyocyte apoptosis tested by Tunel apoptosis kit.The mRNA level of TSP-1 and TRB-3 was determined by quantification real time RT-PCR,while the protein level of TSP-1、A-TGF-β1 and L-TGF-β1 was analyzed by Western blotting and the protein level of TSP-1、TGF-β1、TRB-3 and Chymase was analyzed by immunohistochemistry.Results:Compared with control group,the rats blood glucose,cholesterol,triglycerides of Shengmai San group were significantly decreased.The Myocardial tissue was less damaged and the collagen content was less than control group.The expression of tsp-1,A-TGF-1 and L-TGF-β1 of the mixed liquor of Shengmai San and Danshen Decoction group in the diabetic cardiac muscle were much less than that in control group.The mRNA level of tsp-1 and TRB-3 were lower than control group by PCR detection.Conclusion:Shengmai San can inhibit the process of fibrosis in diabetic cardiomyopathy myocardial rats muscle and delay the formation of diabetic cardiomyopathy through of hyperglycemia rats through many signal pathways.",
        "keywords": [
            "Chymase",
            "Diabetic cardiomyopathy",
            "apoptosis",
            "TRB-3",
            "Shengmai San",
            "TGF-β1",
            "TSP-1",
            "Collagen"
        ],
        "authors": [
            {
                "name": "NI Qing",
                "org": "Guang'anmen Hospital China Academy of Chinese Medical Sciences,Beijing ,China"
            },
            {
                "name": "WANG Jie",
                "org": "Guang'anmen Hospital China Academy of Chinese Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHAO An-bin",
                "org": "Medical school of Jinan University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Medical school of Jinan University,Guangzhou ,China"
            },
            {
                "name": "WANG Min",
                "org": "Medical school of Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Chun-rong",
                "org": "Medical school of Jinan University,Guangzhou ,China"
            },
            {
                "name": "LI En-qing",
                "org": "Medical school of Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Basic Medicine in Traditional Chinese Medicine",
        "year": 2010
    },
    "MAkxlOqx": {
        "id": "MAkxlOqx",
        "title": "Study on the protective effect of shengmai san (see text) on the myocardium in the type 2 diabetic cardiomyopathy model rat.",
        "abstract": "To study the effect of Shengmai San ((see text) Pulse-activating Powder) in protecting myocardium in the rat of the type 2 diabetic cardiomyopathy (DCM) model.The DCM rat model was established by combination of insulin resistance induced by a high-fat diet with intraperitoneal injection of high dose streptozotocin (50 mg/kg). And these rat models were randomly divided into three groups: a normal group (n = 12,one of them died), a model group (n = 15) and a Shengmai San group (treatment group, n = 15).The damage of the myocardium was assessed by electrocardiogram at the twelfth week after modeling, and the blood glucose, cholesterol and triglyceride levels were determined; the content of the left cardiac ventricle myocardial collagen was quantified by Masson staining test; the level of myocardial cell apoptosis was detected with TUNEL apoptosis detection kit; the damage extent of the myocardial sub-cellular structures was observed by electron microscopy; the expression levels of cardiac TSP-1 (Thrombospondin-1), TGF-beta1 (Transforming Growth F factor-beta) and TRB-3 (Tribbles homolog 3) proteins were detected by immunohistochemical method; the expression levels of cardiac TSP-1, A-TGF-beta1 and L-TGF-beta1 proteins were detected by Western blotting; and the expression levels of TSP-1 and TRB-3 mRNAs were detected by real-time quantitative PCR.Compared with the control group, the blood glucose, cholesterol, triglycerides levels in both the model groups and the Shengmai San group were significantly decreased; the myocardial tissue was less damaged and the collagen content was reduced in the Shengmai San group; the myocardial sub-cellular structure was injured to a lesser extent; the expression levels of myocardial TSP-1, TGF-beta1, TRB-3, and TSP-1, A-TGF-beta1, L-TGF-beta1 and chymase were decreased, and the expression levels of TSP-1 mRNA and TRB-3 mRNA were decreased in both the model groups and the Shengmai San group (the latter was better),.Shengmai San can inhibit myocardial fibrosis in the rat of diabetic cardiomyopathy, and significantly delay the formation of diabetic cardiomyopathy in hyperglycemia rats through multiple pathways.",
        "keywords": [
            "apoptosis"
        ],
        "authors": [
            {
                "name": "Qing Ni",
                "org": "The Endocrinology Department of Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China."
            },
            {
                "name": "Jie Wang",
                "org": ""
            },
            {
                "name": "En-Qing Li",
                "org": ""
            },
            {
                "name": "An-Bin Zhao",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Chun-Rong Huang",
                "org": ""
            }
        ],
        "venue": "Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan / sponsored by All-China Association of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine",
        "year": 2011
    },
    "Au688T3O": {
        "id": "Au688T3O",
        "title": "Effect of Danshen Decoction on the on the Rats of Type 2 Diabetic Cardiomyopathy",
        "abstract": "Objective: Observe the effect of the DanShen Decoction on the diabetic cardiomyopathy(DCM).Methods: The rat model of DCM was established by eating a high-fat diet together with injection of high dose streptozotocin(50mg/kg) intraperitoneally.After 12 weeks,electrocardiogram was used to evaluate the damage of the myocardial,blood serum GLU,cholesterin and TG were tested by Clinical Chemistry Test Systems.The content of collagen was quantified by Masson staining.Level of cardiomyocyte apoptosis tested by Tunel apoptosis kit.The mRNA level of TSP-1 and TRB-3 was determined by quantification real time RT-PCR,while the protein level of TSP-1、A-TGF-β1 and L-TGF-β1 was analyzed by Western blotting and the protein level of TSP-1、TGF-β1、TRB-3 and Chymase was analyzed by immunohistochemistry.Results: Compared with control group,the rats blood glucose,cholesterol,triglycerides of DanShen Decoction group were significantly decreased.The Myocardial tissue was less damaged and the collagen content was less than control group.The expression of tsp-1,A-TGF-1 and L-TGF-β1 of DanShen Decoction group in the diabetic cardiac muscle were much less than that in control group.The mRNA level of tsp-1 and TRB-3 were lower than control group by PCR detection.Conclusion: DanShen Decoction can inhibit the process of fibrosis in diabetic cardiomyopathy myocardial rats muscle and delay the formation of diabetic cardiomyopathy through of hyperglycemia rats through many signal pathways.",
        "keywords": [
            "Chymase",
            "Diabetic cardiomyopathy",
            "apoptosis",
            "TRB-3",
            "DanShen Decoction",
            "TGF-β1",
            "TSP-1",
            "Collagen"
        ],
        "authors": [
            {
                "name": "NI Qing",
                "org": "Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing ,China"
            },
            {
                "name": "WANG Jie",
                "org": "Guang'anmen Hospital of China Academy of Chinese Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHAO An-bin",
                "org": "Medical School of Jinan University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Medical School of Jinan University,Guangzhou ,China"
            },
            {
                "name": "WANG Min",
                "org": "Medical School of Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Chun-rong",
                "org": "Medical School of Jinan University,Guangzhou ,China"
            },
            {
                "name": "LI En-qing",
                "org": "Medical School of Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Basic Medicine in Traditional Chinese Medicine",
        "year": 2010
    },
    "MVUWYdCK": {
        "id": "MVUWYdCK",
        "title": "Effect of Xuefuzhuyu decoction on cardiomyopathy in type 2 diabetic rats",
        "abstract": "AIM:To observe the pathologic changes of cardiomyopathy in type 2 diabetic rats and the therapeutic effect of Xuefuzhuyu decoction.METHODS: The diabetic model was established by feeding the animals with high-fat diet and injecting a middle dose of streptozotocin (50 mg/kg) intraperitoneally in 42 Wistar male rats. After 8 weeks,the damage of the heart in the model animals was detected by electrocardiogram and echocardiography,and the serum level of glucose,total cholesterol and triglyceride were determined by the methods of clinical chemistry. The content of collagen was quantified by Masson staining. The apoptosis of cardiomyocytes was measured by TUNEL apoptosis kit. The structures of myocardial damage were observed under light and electronic microscopes.RESULTS: (1) Compared with normal group at the same time points,the contents of serum glucose,triglyceride and cholesterol in model group increased (P<0.05). At the 11th and 14th weeks,the thickness of LVDS was significantly increased (P<0.01),the structure of myocardial tissues was severely damaged and collagen fiber content increased obviously (P<0.01). The cell apoptosis was also increased. (2) Compared with control group at the same time points,the contents of serum glucose,cholesterol and triglyceride in Xuefuzhuyu decoction group significantly decreased (P<0.05). The thickness of LVDS at the 11th and 14th weeks was decreased (P<0.05) and LVM at the 14th week became significantly thinner (P<0.01). The damage of the myocardium and subcellular structure was slighter and the content of collagen was lower than that in control group (P<0.05). The cell apoptosis was also attenuated.CONCLUSION: The levels of blood glucose,total cholesterol and triglyceride and the content of collagen fibers increase when diabetic cardiomyopathy develops,with more cell apoptosis and severe damage in the cardiac structure. Xuefuzhuyu decoction decreases the level of blood lipid in diabetic cardiomyopathy,alleviates the pathological changes of myocardial fibrosis and delays the progression of diabetic cardiomyopathy.",
        "keywords": [
            "Xuefuzhuyu decoction",
            "Apoptosis",
            "Diabetic cardiomyopathies"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Department of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou ,China."
            },
            {
                "name": "ZHAO An-bin",
                "org": "Department of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou ,China."
            },
            {
                "name": "CHEN Jing-rui",
                "org": "Department of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou ,China."
            },
            {
                "name": "WANG Min",
                "org": "Department of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou ,China."
            },
            {
                "name": "HUANG Chun-rong",
                "org": "Department of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou ,China."
            },
            {
                "name": "LI En-qing",
                "org": "Department of Traditional Chinese Medicine,School of Medicine,Jinan University,Guangzhou ,China."
            }
        ],
        "venue": "Chinese Journal of Pathophysiology",
        "year": 2010
    },
    "zXQfh66S": {
        "id": "zXQfh66S",
        "title": "Literature Research on TCM Syndrome Factors of Ulcerative Colitis",
        "abstract": "Objective:To probe into the common syndromes,syndrome factors and distribution regularity of ulcerative colitis.Methods:Firstly,literature was selected from January 1979 to December 2011 in CNKI retrieval system by advanced search methods,then a database of 35 articles which met the criteria was established.Secondly,syndrome factors were concluded from the database and classified into different kinds and the syndrome type was summarized.Results:There were totally 9 syndrome factors in 2502 cases of ulcerative colitis patients mainly including 749 cases of qi deficiency(30.46%),1030 cases of yang deficiency(41.17%),725 cases of damp-heat(28.98%) and 524 cases of qi stagnation(20.95%).And all patients could be divided into three types,924 cases of deficiency syndrome(36.93%),968 cases of excess syndrome(57.04%),and 610 cases of syndrome of intermingled deficiency and excess(24.38%).From the statistical analysis,we concluded that damp-heat and qi stagnation were the main excess syndrome factors,while yang deficiency and qi deficiency were the main deficiency syndrome factors,and phlegm-damp and damp-heat were the main syndrome factors of syndrome of intermingled deficiency and excess.Conclusion:The important syndrome factors of ulcerative colitis were qi deficiency,yang deficiency,damp-heat,phlegm-damp and qi stagnation;and there were two fundamental types of ulcerative colitis,one was qi-yang deficiency,the other was qi-stagnancy and blood stasis.",
        "keywords": [
            "ulcerative colitis",
            "regularities of distribution",
            "syndrome type",
            "syndrome factors"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "LI Qifang",
                "org": ""
            },
            {
                "name": "CHEN Jia",
                "org": ""
            },
            {
                "name": "WU Xianlin",
                "org": ""
            },
            {
                "name": "DAI Congqi",
                "org": ""
            },
            {
                "name": "LI Enqing",
                "org": ""
            },
            {
                "name": "HUANG Chunrong",
                "org": ""
            },
            {
                "name": "ZHANG Yupei",
                "org": ""
            },
            {
                "name": "ZHAO Changlin",
                "org": ""
            },
            {
                "name": "ZHANG Tianfeng",
                "org": ""
            },
            {
                "name": "CHEN Xiaoyin",
                "org": ""
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2013
    },
    "cQvT9vMG": {
        "id": "cQvT9vMG",
        "title": "Influence of the ethanol fraction from Platycodon grandiflorum on glucose tolerance of streptozotocin-induced diabetic rat",
        "abstract": "Objective:To study the effect on the glucose tolerance of the diabetic kunming rat of the ethanol fraction from Platycodon grandiflorum A.DC.Methods:Diabetic kunming rat models were induced by i.p.injection of streptozotocin(STZ)assisted with high energy diet,and were divided into different groups,which were given 28d of 2,8g/kg ethanol fraction from Platycodon Grandiflorum A.DC,Acarbose or water respectively.Then the glucose tolerance,serum insulin levels(INS)and insulin sensitivity index(ISI)were tested and the pathology damage of the pancreatic were examined.Result:High doses of the ethanol fraction from Platycodon grandiflorum A.DC improved glucose tolerance,INS,ISI more evidently,and alleviated the pancreas tissue injury.Conclusion:The improvement of the the ethanol fraction from Platycodon grandiflorum A.DC on glucose tolerance related to the improvement of the ISI and the partial repair of the diabetic rats' pancreas tissue.",
        "keywords": [
            "Platycodon grandiflorum",
            "diabetic rat",
            "glucose tolerance"
        ],
        "authors": [
            {
                "name": "Chen Meijuan",
                "org": "NanJing University of Chinese Medicine,Nanjing "
            },
            {
                "name": "Yu Bin",
                "org": "NanJing University of Chinese Medicine,Nanjing "
            },
            {
                "name": "Jiang Yabing",
                "org": "NanJing University of Chinese Medicine,Nanjing "
            },
            {
                "name": "Qian Jianping",
                "org": "NanJing University of Chinese Medicine,Nanjing "
            },
            {
                "name": "Wu Huiping",
                "org": "NanJing University of Chinese Medicine,Nanjing "
            }
        ],
        "venue": "Pharmacology and Clinics of Chinese Materia Medica",
        "year": 2010
    },
    "v1fkdo1m": {
        "id": "v1fkdo1m",
        "title": "PROTECTIVE EFFECTS OF RADIX PSEUDOSTELLARIAE ON RAT CHRONIC HEART FAILURE AND MMPS IN LEFT VENTRICULAR TISSUE INDUCED BY CORONARY ARTERY LIGATION",
        "abstract": "Objective To investigate the protective effects of Radix Pseudostellariae on rat chronic heart failure and matrix metalloproteinases(MMPs) in left ventricular tissue induced by coronary artery ligation.Methods:Rat chronic heart failure was reproduced by ligated coronary artery for 6 weeks.The cardiac function was assayed by hemodynamics parameters;the cardiac fibrosis were investigated by weighting index,hydroxyproline contents of left ventricular tissue,and histopathology check;mRNA expression and activities of MMP-2 and MMP-9 in left ventricular were detected by RT-PCR and gelatin SDS-PAGE zymography.Results: Cardiac function was remarkable turbulence after coronary artery ligation 6 weeks that results from the hemodynamics parameters;it is indicate the cardiac fibrosis after coronary artery ligation 6 weeks according to results of weighting index,hydroxyproline contents of left ventricular tissue,and histopathology check;the activities of MMP-2 and MMP-9 in left ventricular tissue were significantly increased and mRNA contents of MMP-2 and MMP-9 were significantly elevated.Radix Pseudostellariae can remarkable ameliorate the cardiac function,inhibit the activities and mRNA contents of MMP-2 and MMP-9 in left ventricular tissue in chronic rat heart failure after continued 5 weeks treated with decoction of Radix pseudostellariae by ig..Conclusion: The rat chronic heart failure was reproduced by coronary artery ligation after 6 weeks,decoction of Radix Pseudostellariae can ameliorate cardiac disfunction of chronic heart failure,the mechanism maybe involve in mRNA expression and activity of MMP-2 and MMP-9 in cardiac ventricular,then block the cardiac fibrosis and improve the cardiac function.",
        "keywords": [
            "mmatrix metalloproteinases",
            "myocardial infarction",
            "cardiac fibrosis",
            "hemodynamics",
            "rats",
            "reverse transcriptase polymerase chain reaction",
            "pseudostellaria heterophylla"
        ],
        "authors": [
            {
                "name": "TAO Ling",
                "org": "Guiyang Medical College,Guiyang "
            },
            {
                "name": "YU Bin",
                "org": "Nanjing University of Traditional Chinese Medicine,Nanjing "
            },
            {
                "name": "FANG Tai-hui",
                "org": "Nanjing University of Traditional Chinese Medicine,Nanjing "
            },
            {
                "name": "QIAN Zhi-yu",
                "org": "China Pharmaceutical University,Nanjing "
            }
        ],
        "venue": "Guizhou Science",
        "year": 2007
    },
    "ZyFfM6ft": {
        "id": "ZyFfM6ft",
        "title": "Study on General Pharmacology of Schizonepetin",
        "abstract": "Objective:To investigate whether schizonepetin has any influences on the cardiovascular system,the nervous system and the respiratory system of animals.Method:Mice and rats were given oral medicine with different doses of ST in order to evaluate the effects of ST on sleep and the autonomous movement in rats,on the falling number of mice from the rotating stick.Anesthetized dogs were given oral medicine with different doses of ST in order to evaluate the effects of ST on the frequency and depth of respiration,systolic and diastolic blood pressure(SAP,DAP),heart rate(HR),PR,QRS,QT and T-wave.Result:With the dosage,ST had no obvious effect on the number of sleep and the autonomous movement in rats,on the falling number of mice from the rotating stick.With the dosage,ST had no obvious effect on the frequency and depth of respiration,systolic and diastolic blood pressure,heart rate,PR,QRS,QT and T-wave.Conclusion:Experimental dosage for mice,20 times of the clinical adult dosage,is the half dose of LD50 for mice.The study indicates that at this level of dosage ST has no obvious effects on respiratory,cardiovascular and nervous systems.",
        "keywords": [
            "cardiovascular systems",
            "respiratory systems",
            "general pharmacology",
            "schizonepetin",
            "central nervous system"
        ],
        "authors": [
            {
                "name": "ZHU Hui",
                "org": "Nanjing University of Chinese Medicine,Jiangsu Key Laboratory for Modern Research of Traditional Chinese Medical Formulae,Nanjing ,China"
            },
            {
                "name": "ZHANG Liang",
                "org": "Nanjing University of Chinese Medicine,Jiangsu Key Laboratory for Modern Research of Traditional Chinese Medical Formulae,Nanjing ,China"
            },
            {
                "name": "YU Bin",
                "org": "Nanjing University of Chinese Medicine,Jiangsu Key Laboratory for Modern Research of Traditional Chinese Medical Formulae,Nanjing ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Nanjing University of Chinese Medicine,Jiangsu Key Laboratory for Modern Research of Traditional Chinese Medical Formulae,Nanjing ,China"
            },
            {
                "name": "DING An-wei",
                "org": "Nanjing University of Chinese Medicine,Jiangsu Key Laboratory for Modern Research of Traditional Chinese Medical Formulae,Nanjing ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2011
    },
    "OAliBr4Z": {
        "id": "OAliBr4Z",
        "title": "The Effect of Borneol on the Intervention of Shuluo in Middle Cerebral Artery Occlusion Rats",
        "abstract": "Objective To observe protection of Shuluo to MCAO rats and borneol’s effect. Methods Copy the model of middle cerebral artery occlusion in rats and observe the ethology, and interfere in the rats with Shuluo and Shuluo+ borneol respectively, then observe the ethology, cerebral infarction rate, cerebral index, cerebral moisture and tissus were examined. Results Shuluo can improve the neuroethology, decrease the cerebral infarction rate, cerebral index, cerebral moisture and the damage of cerebral ischemia. The borneol can increase the protective effect. Conclusion Shuluo can decrease the cerebral ischemical reperfusion injury, and borneol can strengthen its effect.",
        "keywords": [
            "Ischemia-reperfusion injury",
            "Middle cerebral artery",
            "Shuluo",
            "Brain",
            "Borneol"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": " Biological Science Instition of Nanjing Xiaozhuang College, Jiangsu Nanjing,, China"
            },
            {
                "name": "RUAN Ming",
                "org": " Biological Science Instition of Nanjing Xiaozhuang College, Jiangsu Nanjing,, China"
            },
            {
                "name": "FANG Tai-hui",
                "org": " Biological Science Instition of Nanjing Xiaozhuang College, Jiangsu Nanjing,, China"
            },
            {
                "name": "XU Li",
                "org": " Biological Science Instition of Nanjing Xiaozhuang College, Jiangsu Nanjing,, China"
            },
            {
                "name": "YUAN Dong-ping",
                "org": " Biological Science Instition of Nanjing Xiaozhuang College, Jiangsu Nanjing,, China"
            }
        ],
        "venue": "Journal of Chinese Microcirculation",
        "year": 2009
    },
    "6hgtfY5c": {
        "id": "6hgtfY5c",
        "title": "Effect of electroacupuncture combined with intragastric administration of borneol on the permeability of blood-brain barrier in the mouse]",
        "abstract": "To observe the effect of electroacupuncture (EA) combined with gavage of borneol on the permeability and ultrastructure of the blood-brain barrier (BBB) in mice, so as to reveal its mechanism underlying improving permeability of BBB.For assaying Evans blue (EB) content in the brain, 60 Kunming mice were evenly divided into control, EA, borneol (0.2 g/kg, borneol-0.2), borneol (0.4 g/kg, borneol-0.4), borneol (0.2 g/kg, borneol-0.2) + EA and borneol (0.4 g/kg, borneol-0.4) + EA groups. For determination of P-glycoprotein [P-gp, a member of the superfamily of ATP-binding cassette (ABC) transporters which transport various molecules across extra- and intra-cellular membranes] function and the ultrastructure of BBB, other 84 mice were randomized into control, borneol-0.2, borneol-0.4, borneol-0.2 + EA, borneol-0.4 + EA and verapamil groups (n=10 for P-gp. function analysis, and n 2 for electron microscopic observation). EA (2 Hz, 1 mA) was applied to \"Baihui\" (GV 20) and \"Yamen\"(GV 15) for 20 ml once daily for 14 days. EB (2.5%, 0.2 mL/kg) and rhodamine (Rh) 123 (0.2 mg/kg) were injected intravenously first through the tail vein, and their contents in the brain and Rh 123 in the plasma were detected after EA by using an ultraviolet fluorescence microplate reader. At the same time, the permeation index (Kp) was calculated by the ratio of Rh 123brain/Rh 123blood.Compared with the control group, the cerebral EB and Rh 123 contents and Kp of BBB in the EA, borneol-0.2, borneol-0.4, borneol-0.2 + EA, borneol-0.4 + EA and verapamil groups were increased significantly (P < 0.05, P < 0.01). The cerebral EB content was significantly higher in the borneol-0.2 + EA group than in the borneol-0.2 group (P < 0.05), suggesting a synergistic effect of EA and borneol. No significant differences were found among the EA, borneol-0.2 and borneol-0.4 groups in cerebral EB levels, among the control, EA, borneol-0.2, borneol-0.4, borneol-0.2 + EA, borneol-0.4 + EA and verapamil groups in plasma Rh 123 contents, and among the EA, borneol-0.2, borneol-0.4, borneol-0.2 + EA, borneol-0.4 + EA and verapamil groups in cerebral Rh 123 contents and Kp of BBB (P > 0.05). Results of the electron transmission microscope showed that the compact degree of the tight junction of BBB was decreased in the borneol-0.2, borneol-0.4, borneol-0.2 + EA, borneol-0.4 + EA groups but not in the EA group.EA and gavage of borneol treatments may enhance the permeability of BBB for EB and Rh 123 and have a certain synergistic effect in mice. The effect of borneol may be closely with the inhibition of P-glycoprotein and the decrease of tight junction of BBB while the effect of EA treatment is probably related to the inhibition of P-glycoprotein only.",
        "keywords": [
            "p-glycoprotein",
            "borneol",
            "bbb",
            "ea",
            "ultrastructure"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Gao-hong Lü",
                "org": ""
            },
            {
                "name": "Yong Sun",
                "org": ""
            },
            {
                "name": "Xin Lin",
                "org": ""
            },
            {
                "name": "Tai-hui Fang",
                "org": ""
            }
        ],
        "venue": "Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji]",
        "year": 2011
    },
    "gLM2mHYK": {
        "id": "gLM2mHYK",
        "title": "Comparative study on effects of Rubiae Radix et Rhizoma and carbonized Rubiae Radix et Rhizoma on acute blood stasis rat model]",
        "abstract": "To observe the effects of Rubiae Radix et Rhizoma (RRR) and carbonized Rubiae Radix et Rhizoma (CRRR) on the acute blood stasis rat model, and reveal their differences in efficacy.The acute blood stasis model was induced by subcutaneously injecting adrenaline hydrochloride and soaking in ice water. Yunnan Baiyao was used as the positive control drug, and administered for consecutively seven days. This model was adopted to observe the effect of high, middle and low dose RRR and CRRR groups on hemorheology, thrombin activity, and blood platelet system.RRR could significantly reduce the wholeblood viscosity and plasma viscosity of blood stasis rats under different shear rates, and showed certain two-way regulating function in hemostasis. It also showed certain effect on ADP-induced platelet aggregation rate, but which was lower than CRRR. CRRR achieved the main hemostatic mechanism by stimulating intrinsic and extrinsic blood coagulation and fibrinogen, and could significantly enhance the platelet aggregation rate of rats in the acute blood stasis model (P <0. 01).RRR had the effect of removing blood stasis and hemostasis, while CRRR mainly has the hemostatic effect. This further demonstrates the traditional processing theory of \"promoting blood circulation with crude herbs and stopping bleeding with processed herbs\".",
        "keywords": [],
        "authors": [
            {
                "name": "Ming-Qiu Shan",
                "org": ""
            },
            {
                "name": "Xing Chen",
                "org": ""
            },
            {
                "name": "Juan Li",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "An-Wei Ding",
                "org": ""
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2014
    },
    "caYGfrep": {
        "id": "caYGfrep",
        "title": "Effects and mechanisms of platycladi cacumen carbonisatum on rats with blood-heat and hemorrhage syndrome]",
        "abstract": "To discuss the effect and mechanism of Platycladi Cacumen Carbonisatum (PCC) on rats with blood heat and hemorrhage syndromes.Rats were fed with 15 g x kg(-1) water decoctions of Zingiberis Rhizoma and 5% alcohol for 15 days to establish the blood-heat and hemorrhage syndrome model. Yunnan Baiyao was taken as the positive control drug, and PCC decoctions (5.0, 10.0 g x kg(-1)) were given simultaneously, in order to detect changes in general physical signs of rats, such as body weight, daily diet, volume of daily drinking and urine and stool, and rectal temperature. Automatic hematology analyzers was used to determine white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), and hematocrit (HCT), blood time by docking (BT). Blood rheometers was used to detect whole blood and plasma viscosities, thrombin time (TT), activated partial thromboplastin time (APTT), prothrombin time (PT) and fibrinogen content (FIB). Indexes related to thyroid functions, such as triiodothyronine (T3), tetraiodothyronine (T4), reverse triiodothyronine (rT3) and thyroid stimulating hormone (TSH) were measured by radio-immunoassay, and changes in lung tissues were observed by hematoxylin-eosin (HE) stain.After modeling, rats witnessed slow-down in weight growth rate, significant increase in daily diet, volume of daily drinking, urine and temperature, significant decrease in stools and their water content (P < 0.05, P < 0.01), rise in plasma T4 level, notable growth in T3 and rT3 concentrations (P < 0.05), decline in TSH concentration. Additionally, their WBC, RBC, HGB and HCT remarkably increased (P < 0.05, P < 0.01), with significant increase in high, middle and low whole blood viscosities and plasma viscosity (P < 0.01); their BT, TT, APTT were notably prolonged (P < 0.01), with significant increase in FIB content (P < 0.01). After oral administration of Yunnan Baiyao or PCC, rats of all groups showed significant improvement in blood heat syndromes (P < 0.05, P < 0.01), and their blood coagulation indexes including BT, TT, APTT, FIB, thyroid function indexes including T4, T3, rT3, TSH, WBC, RBC, HGB, HCT, whole blood viscosity and plasma viscosity were getting normal (P < 0.05, P < 0.01).PCC can ameliorate blood heat symptoms and pathologic hemorrhage among rats with blood heat and hemorrhage syndromes by inhibiting thyroid functions and correcting hemorheological and coagulation disorders.",
        "keywords": [
            "to cool blood and stop bleeding",
            "thyroid function",
            "blood heat and hemorrhage syndromes",
            "blood coagulation",
            "platycladi cacumen carbonisatum",
            "hemorheology"
        ],
        "authors": [
            {
                "name": "Jia Liu",
                "org": "Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "Li Zhang",
                "org": "Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "Ying-Zhi Yao",
                "org": "Basic Medical School,Nanjing University of Chinese Medicine, Nanjing ,China"
            },
            {
                "name": "An-Wei Ding",
                "org": "Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "Bin Yu",
                "org": "Province and Ministry Cooperation Lab of Pharmacology of Chinese Medicine,Nanjing University of Traditional Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "Ming-Qiu Shan",
                "org": "Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "Wei-Feng Yao",
                "org": "Jiangsu Key Laboratory for High Technology Research of Traditional Chinese Medicine Formulae,Nanjing University of Chinese Medicine,Nanjing ,China"
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2013
    },
    "0CpgDL6Y": {
        "id": "0CpgDL6Y",
        "title": "Influence of electroacupuncture plus intragastric administration of extract of hypericum perforatum L on ethology and brain microcirculation in depression rats]",
        "abstract": "To observe the effect of combined administration of intragastric perfusion of extract of Hypericum Perforatum L (HP-L) and electroacupuncture (EA) of \"Baihui\" (GV 20) and \"Yamen\" (GV 15) on behavior and brain microcirculation in depression rats.Female SD rats were randomized into control, model, lower-dose of HP-L (lower-dose in short, 10 mg/kg), lower-dose+ EA, higher-dose (20 mg/kg) and higher-dose+ EA groups (n = 10/group). Depression model was established by lonely raising and chronic unpredictable mild stress (tail cramping, water-deprivation, fasting, electrical shock stimulation, etc. ) for 21 days. EA (2 Hz, 1 mA) was applied to \"Baihui\"(GV 20) and \"Yamen\"(GV 15) for 20 min, once daily for 14 days. Changes of ethology including glucose-consumption during 1 h, crossing and rearing scores of open-field test during 3 min (for assessing the rats' locomoto)and laser Doppler flowmetry values of cortical regional cerebral bloodflow (r CBF) were detected, and Morris water maze test (for assessing the rats' learning-memory ability) was conducted.In comparison with the control group, the sucrose consumption, crossing and rearing scores of open-field test, the average swimming velocity (ASV). the ratios of path length and swimming duration near the hidden-platform and the path length and swimming duration far from the platform of Morris water maze test during 70 seconds, and the cortical r CBF value in the model group were decreased significantly (P < 0.01), while the total swimming distance and escape latency in the model group increased apparently (P < 0.01). Compared to the model group, the average sucrose consumption, crossing and rearing scores of open-field test, the ASV, and the ratios of path length and swimming duration near the platform and those far from the platform in the lower-dose. lower-dose + EA, higher-dose and higher-dose + EA groups, and the cortical r CBF in the lower-dose + EA and higher-dose + EA groups were increased considerably (P < 0.05, P < 0.01). The total swimming distances and escape latencies of lower-dose, lower-dose + EA, higher-dose and higher-dose + EA groups were significantly shortened in comparison with the model group (P < 0.05, P < 0.01). The sucrose consumption and crossing score were significantly higher in the higher-dose + EA group than the lower-dose group (P < 0.05). The escape latency was significantly shorter in the higher-dose + EA group than in the lower-dose group (P < 0.05). No significant differences were found among the lower-dose, lower-dose + EA and higher-dose groups the sucrose consumption, crossing score and escape latency: among the lower-dose, lower-dose + EA, higher-dose and higher-dose + EA groups in the rearing score and ASV; among the lower-dose, higher-dose and model groups in the cortical r CBF (P > 0.05).EA can enhance the effect of extract of HP-L in increasing sucrose consumption, crossing score and cerebral blood flow, and in shortening escape latency in depression rats, which may contribute to their effect in improving depression. But HP-L itself has no effect on cortical microcirculation.",
        "keywords": [
            "depression",
            "cortical microcirculation",
            "electroacupuncture",
            "behavior",
            "hypericum perforatum l"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Key Laboratory of Integrative Acupuncture and Drugs of Jiangsu Province and Education Ministry of PR China, Nanjing University of Chinese Medicine, Nanjing 210046, China."
            },
            {
                "name": "Yong Sun",
                "org": ""
            },
            {
                "name": "Gao-Hong Lü",
                "org": ""
            },
            {
                "name": "Jin-Fu Lu",
                "org": ""
            },
            {
                "name": "Tai-Hui Fang",
                "org": ""
            }
        ],
        "venue": "Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji]",
        "year": 2011
    },
    "IZMzCD3X": {
        "id": "IZMzCD3X",
        "title": "Advance on Study of Cells of Blood-brain Barrier",
        "abstract": "This article summarized and analyzed the cell composition and different functions of blood-brain barrier.Searching recent studies on blood-brain barrier function and particular structure of relative cells and interaction between different cells in 10 years through CNKI,PubMed,Elsevier,etc databases.The blood-brain barrier cells included asement membrane,neuron,small glial cells,pericytes,astrocytes,and endothelial cells etc,each cell played an importantrole in the formation of the blood brain barrier function.The study of the blood-brain barrier has become a key research area.The research work on cell composition of the blood-brain barrier in recent years has achived barrier-related research.",
        "keywords": [
            "blood-brain barrier",
            "cell",
            "research progress",
            "function"
        ],
        "authors": [
            {
                "name": "DONG Xiao-ping",
                "org": "Nanjing University of Chinese Medicine,Nanjing ,China;Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing ,China"
            },
            {
                "name": "YU Bin",
                "org": "Nanjing University of Chinese Medicine,Nanjing ,China;Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing ,China"
            },
            {
                "name": "JIN Lu",
                "org": "Nanjing University of Chinese Medicine,Nanjing ,China;Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing ,China"
            },
            {
                "name": "FANG Tai-hui",
                "org": "Nanjing University of Chinese Medicine,Nanjing ,China;Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2012
    },
    "laCCQWhe": {
        "id": "laCCQWhe",
        "title": "Effects of CVB-D on hemodynamic in anaesthetized dogs in vivo]",
        "abstract": "To investigate hemodynamic in anaesthetized dogs after the intravenous injection of cyclovirobuxine D (CVB-D).The hemodynamic of anaesthetized dogs were observed after intravenous injection of CVB-D at doses of 0.1, 0.2, 0.4 mg/kg.CVB-D of 0.2 and 0.4 mg/kg could decrease HR, TPVR and increase CBF. In addition, CVB-D of 0.4 mg/kg could increase SAP and SV. Yet MAP and CO of dogs showed no remarkable changes with the treatment of CVB-D.CVB-D has effect of improving cardiac function, which may be the mechanism of anti-myocardial ischemia effect of CVB-D.",
        "keywords": [
            "anaesthetized dogs",
            "cvb-d",
            "hemodynamic"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Jiangsu key laboratory for pharmacology and safety evaluation of Chinese materia medica,Nanjing University of TCM,Nanjing ,China"
            },
            {
                "name": "Ming Ruan",
                "org": "Institute of medicinal fungi,Nanjing Xiaozhuang college,Nanjing ,China"
            },
            {
                "name": "Xiang-Chun Shen",
                "org": "Department of Pharmacology,Guiyang Medical College,Guiyang ,China"
            },
            {
                "name": "Li Xu",
                "org": "Jiangsu key laboratory for pharmacology and safety evaluation of Chinese materia medica,Nanjing University of TCM,Nanjing ,China"
            },
            {
                "name": "Hong Zheng",
                "org": "Jiangsu key laboratory for pharmacology and safety evaluation of Chinese materia medica,Nanjing University of TCM,Nanjing ,China"
            },
            {
                "name": "Tai-Hui Fang",
                "org": "Jiangsu key laboratory for pharmacology and safety evaluation of Chinese materia medica,Nanjing University of TCM,Nanjing ,China"
            }
        ],
        "venue": "Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials",
        "year": 2011
    },
    "E3yfcs5j": {
        "id": "E3yfcs5j",
        "title": "Protective effects of Danshenjin on acute myocardial ischemia",
        "abstract": "Objective:To observe the protective effects of Danshenjin on acute myocardial ischemia.Methods:The acute myocardial ischemia models induced by injecting pituitrin in rats and ligating the anterior descending branch of the nearside coronary artery in dogs were established to investigate the protective effects of Danshenjinonacute myocardial ischemia.Results:Danshenjin was able to reduce the fluctuation of T waves in cardiogram(P<0.05,P<0.01) in rat induced by pituitrinsignificantly and inhibit the increase of the S-T segment(Σ-ST,N-ST),decrease the release of cardiac CK and LDH(P<0.05,P<0.01).Conclusion:Danshenjin can remarkably protectacute myocardial ischemiamodels of Pit induced and the anesthetic dogs mediated by ligating coronary artery.",
        "keywords": [
            "Danshenjin",
            "acute myocardialischemia",
            "pituitrin"
        ],
        "authors": [
            {
                "name": "YAO Nan",
                "org": "Pharmacological Department of Nanjing University of TCM,Nanjing ,Jiangsu,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Pharmacological Department of Nanjing University of TCM,Nanjing ,Jiangsu,China"
            },
            {
                "name": "YU Bin",
                "org": "Pharmacological Department of Nanjing University of TCM,Nanjing ,Jiangsu,China"
            },
            {
                "name": "FANG Tai-hui",
                "org": "Pharmacological Department of Nanjing University of TCM,Nanjing ,Jiangsu,China"
            }
        ],
        "venue": "Chinese Archives of Traditional Chinese Medicine",
        "year": 2006
    },
    "0j6pHZgp": {
        "id": "0j6pHZgp",
        "title": "Xinanling's Effects on Haemodynamics of Anesthetized Dogs",
        "abstract": "OBJECTIVE To explore the haemodynamics effect of Xin'anling on anesthetized dogs.METHODS We observed Xin'anling's influence on blood pressure,heartbeat,cardiac output,coronary blood flow,oxygen consumption,etc.of anesthetized dogs after being taken mid-sternal thoracotomy.RESULTS Xin'anling significantly reduced diastolic blood pressure,pulse pressure difference,heartbeat,total peripheral vascular resistance,and total oxygen consumption of the dogs.CONCLUSION Xin'anling can bring down afterload,reduce cardiac work,and improve cardiac function without decreasing blood supply by heart,which indicates that this medicine is able to better cardiovascular system.",
        "keywords": [
            "haemodynamics",
            "dogs",
            "Xin'anling"
        ],
        "authors": [
            {
                "name": "YU Yun",
                "org": "Jiangsu Key Laboratory for Drug Effect and Safety of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "XU Li",
                "org": "Jiangsu Key Laboratory for Drug Effect and Safety of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "BIAN Yong",
                "org": "Jiangsu Key Laboratory for Drug Effect and Safety of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "CAI Xiao-jun",
                "org": "Jiangsu Key Laboratory for Drug Effect and Safety of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "YU Bin",
                "org": "Jiangsu Key Laboratory for Drug Effect and Safety of Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing,,China"
            }
        ],
        "venue": "Journal of Nanjing University of Traditional Chinese Medicine",
        "year": 2012
    },
    "yslGf00X": {
        "id": "yslGf00X",
        "title": "Study on optimal screening of rat model with blood stasis due to cold syndrome",
        "abstract": "OBJECTIVE To investigate the effects of freezing time on setting up a rat model of blood stasis due to cold and to provide an experimental model for the study of blood stasis due to cold syndrome with Chinese medicine.METHODS The rats were divided randomly into 5 groups,namely control group,5-day group,10-day group,15-day group and 20-day group.Except those in control group,the rest rats in other groups were induced blood stasis due to cold syndrome by kept in 0 ℃ ice water lasting for 15 mins one time a day.The complete blood count indexes,ovary index,uterus index and blood rheology were carefully observed.RESULTS Compared with control group,the erythrocytes of rats in 5-day and 10-day group were dramatically reduced,the APTT dramatically extended(P<0.01).In 5-day group,plasma viscosity,blood viscosity and erythrocyte aggregation index(EAI) reduced dramatically,erythrocyte deformability improved significantly,hemoglobin decreased remarkably,and uterus index declined significantly(P<0.05~0.01).The 10-day group also showed that the percentage of neutrophils increased significantly and TT shortened remarkably(P<0.05~0.01).In 10-day and 15-day group,both of their HCT reduced obviously.HBX of 10-day group declined,while that of 15-day group increased significantly(compared with the control group,P<0.01).Besides,TT obviously shortened(P<0.05),plasma viscosity increased significantly(P<0.01),and APTT also tended to be short in 15-day group.When frozen time lasted for 20days,PT and APTT were prolonged significantly(P<0.01).But rectal temperature of rats in each group had no significant change during the whole modeling process(compared with control group,P>0.05).CONCLUSION Making model on the 10th and 15th day of modeling,coagulative function improved,and abnormal hemorheology was the most obvious in 15-day group compared with other groups.The modeling approach may provide new ideas for the research of blood stasis due to cold syndrome.",
        "keywords": [
            "blood stasis due to cold syndrome",
            "syndrome",
            "animal model"
        ],
        "authors": [
            {
                "name": "XIE Bo",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica of Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "DENG Hai-shan",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica of Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "YU Bin",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica of Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "FANG Tai-hui",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica of Nanjing University of Chinese Medicine,Nanjing,,China"
            }
        ],
        "venue": "Journal of Nanjing University of Traditional Chinese Medicine",
        "year": 2013
    },
    "i7flsRlw": {
        "id": "i7flsRlw",
        "title": "Filtration of active fractions with hemostasis effect from platycladi cacumen carbonisatum]",
        "abstract": "To discuss the hemostasis of the different polarities of Platycladi Cacumen Carbonisatum (PCC) on the blood heat and hemorrhage syndrome rat model induced by dry yeast.The SD rats were divided into seven groups. Yunnan Baiyao was taken as the positive control drug. The rats in the control group and model group were fed with CMC-Na for 7 days, and the rats in other groups were fed with corresponding drugs simultaneously. On day 7, the blood heat and hemorrhage syndrome rat model was established. Indexes including the whole blood viscosity, plasma viscosity, thrombin time (TT), activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen content (FIB), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), blood platelet count (PLT), thrombocytocrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW) and the rate of platelet aggregation induced by ADP were detected. Additionally, the pathological examinations of lungs among each group were compared.Compared with the control group, the RBC, HGB and HCT of rats in the model group increased significantly, with distinct increase in high, middle and low whole blood viscosity and plasma viscosity of rats in the model group; TT and APTT were notably prolonged, while PT was notably shortened, with significant increase in FIB content; PLT, PCT, MPV and PDW remarkably increased; Additionally, the rate of platelet aggregation induced by ADP significantly decreased. After ig administration of the ethyl acetate extract of PCC, the low whole blood viscosity and plasma viscosity remarkably decreased; TT and APTT were significantly shortened, with notable reduction in PDW and in FIB content Additionally, the rate of platelet aggregation induced by ADP significantly increased. The injury of lungs was also improved in ethyl acetate extract group. The rate of platelet aggregation induced by ADP of n-butanol extract group notablly increased. Plasma viscosity of water extract group remarkably decreased, with TT being significantly shortened. But the effects of n-butanol extract or water extract were weaker than that of ethyl acetate extract. And the effect of petroleum ether extract was the weakest.Ethyl acetate extract is the active part of PCC, showing the effect of hemostasis by reducing the low whole blood and plasma viscosity, improving coagulation function mainly by acting on the endogenous coagulation, and ameliorating the function of platelet aggregation.",
        "keywords": [],
        "authors": [
            {
                "name": "Chen Liu",
                "org": ""
            },
            {
                "name": "Jia Liu",
                "org": ""
            },
            {
                "name": "Chuan-Zhu Zheng",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "An-Wei Ding",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica",
        "year": 2014
    },
    "PK9taUSf": {
        "id": "PK9taUSf",
        "title": "Protective action and mechanistic investigation of GC granules on rats metrorrhagia",
        "abstract": "Aim To observe the protective action of GC granules on rats metrorrhagia.Method Our research was conducted on rats uterine hemorrhage model by using mifepristone and misoprostol.GC granules'effect was observed on the metrorrhagic period.Polyphysiograph was used to keep records both on the amplitude and the frequency of the uterine contraction.The method of radioimmunoassay(RIA)was applied to measure the content of estradiol and progestin.Results All three experimental groups separately using small,medium and large dosage succeeded not only in reducing the time duration of the rats'metrorrhagia but also in extending the amplitude of uterine contraction.However,the experiments did not see any notable effect on the frequency of urterine contraction.Conclusion GC granules exert positive effect on lessening uterine bleeding in the body of rats,which,to a large degree,attributes to the intensity of its contraction as well as the level of serotonin.",
        "keywords": [
            "GC granules",
            "metrorrhagia"
        ],
        "authors": [
            {
                "name": "XIE Bo",
                "org": "Nanjing Universtiy Traditional Chinese Medicine Jangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medical,Nanjing,Jiangsu "
            },
            {
                "name": "YU Bin",
                "org": "Nanjing Universtiy Traditional Chinese Medicine Jangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medical,Nanjing,Jiangsu "
            },
            {
                "name": "YU Yun",
                "org": "Nanjing Universtiy Traditional Chinese Medicine Jangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medical,Nanjing,Jiangsu "
            },
            {
                "name": "FANG Tai-hui",
                "org": "Nanjing Universtiy Traditional Chinese Medicine Jangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medical,Nanjing,Jiangsu "
            }
        ],
        "venue": "Anhui Medical and Pharmaceutical Journal",
        "year": 2011
    },
    "dbBBt6ZC": {
        "id": "dbBBt6ZC",
        "title": "Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall.",
        "abstract": "The current study was designed to explore the mechanism of the prokinetic activity of Gentiopicroside (Ge), from Gentiana macrophylla Pall which is widely used to strengthen gastric motility in clinic.Gastrointestinal motility disorder rats were induced by stress stimulation and the rats were treated with Ge. The functions of gastric emptying and intestinal propelling were measured after blood was obtained to assay the levels of plasmatic motilin (MTL), vasoactive intestinal peptide (VIP), somatostatin (SST), gastrin (GAS), neurotensin (NT) and substance of P (SP). The expressions of MTL receptor (MTLR), VIP receptor 2 (VIPR2) and SST receptor 2 (SSTR2) were measured also. In addition, an isolated guinea pig ileum was applied to evaluate the influences of Ge on M-R, H1-R, 5-HT4-R and D-R in vitro.Ge increased gastric emptying and intestinal propelling obviously. It also decreased the level of SST and increased GAS in plasma significantly. Moreover, it promoted the expressions of MTLR in gastric antrum, duodenum, jejunum and ileum, and restrained the expression of VIPR2 in duodenum. Piboserod and loratadine had no obvious restrain to Ge' exciting ileum effect and Ge also didn't affect dopamine paralyzing ileum. However, Ge failed to improve the hypofunction of guinea pigs ileums pre-treated with atropine sulfate.The mechanisms of Ge' prokinetic effect were associated with modulating the levels of SST and GAS in plasma, raising the expressions of MTLR in gastric antrum, duodenum, ileum and jejunum, reducing the expression of VIPR2 in duodenum and activating M-R.",
        "keywords": [
            "gastrointestinal hormones",
            "gastrointestinal prokinetic effect",
            "gentiopicroside",
            "gentiopicroside (pubchem cid: 88708)",
            "muscarinic acetylcholine receptor agonist"
        ],
        "authors": [
            {
                "name": "Ruan Ming",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China; School of Food Science, Nanjing Xiaozhuang University, Nanjing 211171, PR China."
            },
            {
                "name": "Yu Bin",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China."
            },
            {
                "name": "Xu Li",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China."
            },
            {
                "name": "Zhang Liang",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China."
            },
            {
                "name": "Long Jun",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, PR China."
            },
            {
                "name": "Shen Xiangchun",
                "org": "Guiyang Medical University, Guiyang 550004, PR China."
            }
        ],
        "venue": "Fitoterapia",
        "year": 2015
    },
    "9pjjalvH": {
        "id": "9pjjalvH",
        "title": "Effects of Radix Pseudostellariae on Cardiac Remodeling in Rats with Chronic Heart Failure Induced by Acute Cardiac Infarction and Its Mechanism",
        "abstract": "Objective:To investigate the effects of Radix Pseudostellariae on cardiac remodeling of chronic heart failure induced by acute cardiac infarction after coronary artery ligation and its mechanism. Methods:Rat chronic heart failure was produced by coronary artery ligation of 6 weeks. The cardiac remodeling was evaluated with remodeling indexes such as left and right ventricular indexes,lung index,and globular index,etc. The death ratio of model rats was used to indicate the heart failure degree. Cytokine of IL-2 and TNF-α were detected by ELISA to explore the mechanism of Radix Pseudostellariae. Results:During the process of heart failure caused by coronary artery ligation and the heart muscle remodeling,the death rate of model rats was 43.8%,heart and lung indexes,heart remodeling index and serum levels of IL-6 and TNF-α were significantly higher in modeling group than those of sham operation group. After the treatment of Radix Pseudostellariae decoction by ig for continuous 5 weeks,the death rate,cardiac remodeling indexes,and serum levels of IL-6 and TNF-α markedly decreased. Conclusion:Long-term use of Radix Pseudostellariae can ameliorate cardiac remodeling of the chronic heart failure induced by acute cardiac infarction and the one of the mechanisms might be its influence to cytokine.",
        "keywords": [
            "cardiac infarction",
            "cardiac remodeling",
            "pseudostellariae",
            "radix",
            "tumor necrosis factor",
            "cardia failure",
            "rats",
            "interleukin-6"
        ],
        "authors": [
            {
                "name": "SHEN Xiangchun",
                "org": "Department of Pharmacology,Guiyang Medical College,Guiyang ,Guizhou,China; Nanjing University of TraditionalChinese Medicine,Nanjing ,Jiangsu,China"
            },
            {
                "name": "PENG Jiao",
                "org": "Department of Pharmacology,Guiyang Medical College,Guiyang ,Guizhou,China"
            },
            {
                "name": "YU Bin",
                "org": " Nanjing University of TraditionalChinese Medicine,Nanjing ,Jiangsu,China"
            },
            {
                "name": "QIAN Zhiyu",
                "org": " China Pharmaceutical University,Nanjing ,Jiangsu,China"
            }
        ],
        "venue": "Journal of Guiyang Medical College",
        "year": 2008
    },
    "J4D5tY38": {
        "id": "J4D5tY38",
        "title": "Effects of Salvianolic Acid B Injection on Hemodynamic Ariables in Anaesthetized Open-chest Dogs in Vivo",
        "abstract": "OBJECTIVE To investigate hemodynamic ariables in anaesthetized open-chest dogs after the intravenous injection of salvianolic acid B.METHODS The hemodynamic ariables of open-chest dogs were observed after intravenous injection of salvianolic acid B(SAL-B) at doses of 0.8,1.6,3.2 mg·kg-1.RESULTS 3.2 mg·kg-1 SAL-B had the potency of decreasing the DAP,MAP,and HR of the experimental dogs in first 30 minutes,3.2 mg·kg-1 of SAL-B significantly increased CBF and decreased LVEDP of the experimental dogs.And these test results in experimental group were significantly different from those in control group at some time points.CONCLUSIONS SAL-B has effect of improving cardiac function,which indicates SAL-B has a well perspective of clinical value.",
        "keywords": [
            "coronary disease",
            "intravenous injection",
            "dogs",
            "salvianolic acid B",
            "hemodynamics",
            "cardiac muscle ischemia"
        ],
        "authors": [
            {
                "name": "ZHANG Liang",
                "org": "Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "YUAN Dongping",
                "org": "Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "XU Li",
                "org": "Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "SHEN Xiangchun",
                "org": "Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "FANG Taihui",
                "org": "Department of Pharmacology,Nanjing University of Chinese Medicine,Nanjing ,China"
            }
        ],
        "venue": "Chinese Journal of Modern Applied Pharmacy",
        "year": 2009
    },
    "iL6SNyM5": {
        "id": "iL6SNyM5",
        "title": "The improvement and evaluation of the myocardial infarction-induced heart failure model in rats",
        "abstract": "Aim To provide a improved method of establishing myocardial infarction-induced heart failure model in rats and a comprehensive evaluation system.Method On the basis of the conventional means of establishing heart failure rats model derived from myocardial infarction,we optimized the procedures by modifying the choice of weight,dose of anaesthetics,management of intubation,exposure of heart,treatment of suture and cardiopulmonary press.After coronary ligature,we observed the death rate,physical signs,echocardiography,hemodynamic,left ventricular microcirculation,mass index,pathology and ultrastructure of failure rats.Results The way of constructing failure model of rats in this paper could decrease death rate compared with the conventional method.At the same time,EF,LVFS,CO,SV and CI decreased obviously compared with the sham group,LVESV,LVW,HM,LVMI and HMI increased significantly comparing with the sham group.We also discovered the disturbance of left ventricular microcirculation and abnormality of histology and ultrastructure in failure rats.Conclusion The method of creating heart failure rats in this paper could increase the survival rate and success rate of the model.In addition,a better evaluation system of cardiac failure was also established in this study.",
        "keywords": [
            "ultrastructure",
            "improved model",
            "evaluation sysem",
            "myocardial infarction-induced heart failure",
            "hemodynamic",
            "echocardiography"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "1.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,;2.Province and Ministry Cooperation Lab of Pharmacology of Chinese Medicine,"
            },
            {
                "name": "ZHOU Jing",
                "org": "2.Province and Ministry Cooperation Lab of Pharmacology of Chinese Medicine,"
            },
            {
                "name": "Lü Gao-hong",
                "org": "2.Province and Ministry Cooperation Lab of Pharmacology of Chinese Medicine,"
            },
            {
                "name": "XU Hui-qin",
                "org": "2.Province and Ministry Cooperation Lab of Pharmacology of Chinese Medicine,"
            },
            {
                "name": "LI Wei",
                "org": "3.Dept of Pharmacy,College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing ,China"
            },
            {
                "name": "FANG Tai-hui",
                "org": "1.Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2011
    },
    "CWQfrRTB": {
        "id": "CWQfrRTB",
        "title": "Transformation of astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus]",
        "abstract": "To study the transformation of Astragaloside IV in bidirectional solid fermenting of Astragalus membranaceus var. mongholicus.The chemical components of pre and post-fermenting were comparatively analyzed by techniques of HPLC, column chromatography and spectral identification. Antioxidant effect of transformational product on vascular endothelial cells was researched.In fermenting of Astragalus membranaceus, Astragaloside IV was transformed into 6-O-beta-D-glucoside cycloastragenol, which had significant antioxidant effect.Biotransformation of Astragaloside IV in Astragalus membranaceus was occurred after bidirectional solid fermenting with Ganoderma lucidum, and the biotransformation could enhance effect.",
        "keywords": [
            "6-o-β-d-glucoside cycloastragenol",
            "ganoderma lucidum(curtis:fr.)p.karst.",
            "bidirectional solid fermentation",
            "astragaloside iv",
            "astragalus membranaceus(fisch.) bge.var.mongholicus(bge.) hsiao"
        ],
        "authors": [
            {
                "name": "Ming Ruan",
                "org": "Institute of Medicinal Fungi,Department of Life Science,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "Li-Yang Zhang",
                "org": "Institute of Medicinal Fungi,Department of Life Science,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica,Nanjing University of TCM,Nanjing ,China"
            },
            {
                "name": "Yu-Sheng Chen",
                "org": "Institute of Medicinal Fungi,Department of Life Science,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "Yi Zhuang",
                "org": "Mycological Society of China,Research Center of Medical Mycology,Nanjing University of TCM,Nanjing ,China"
            }
        ],
        "venue": "Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials",
        "year": 2010
    },
    "wzcAIQNk": {
        "id": "wzcAIQNk",
        "title": "The mechanism of the opening of the blood-brain barrier by borneol: A pharmacodynamics and pharmacokinetics combination study.",
        "abstract": "Borneol is widely used in traditional Chinese medicine to facilitate the distribution of central nervous system (CNS) drugs in brain due to its ability to open blood-brain barrier (BBB), however, the underlying mechanism is still unclear. In this study, the effect of borneol on different brain regions were investigated to explore the mechanism.After oral administration of borneol (0.1, 0.2g/kg) for seven consecutive days, SD rats were injected with Rh123 (1.0mg/kg). The concentrations of Rh123 were detected in four brain regions of cortex, hippocampus, hypothalamus and striatum by a small animal vivo imaging system and a fluorescence microplate reader respectively. The ultrastructures of BBB were examined. Moreover, the expressions of the four transporters of ATP-binding cassette (ABC) family, multidrug resistance 1a (Mdr1a), multidrug resistance 1b (Mdr1b), multidrug resistance protein 1 (Mrp1), Mrp4, Mrp5 and breast cancer resistance protein (Bcrp) in the four brain regions were analyzed. Finally, the deliveries of borneol in the plasma and the four brain regions were examined by a pharmacokinetics study.Administration of 0.2g/kg borneol produced loose structure in the tight junction and void structure between the endothelial cell and mesangial cell. Borneol at 0.1g/kg and 0.2g/kg increased the delivery of Rh123 in hippocampus and hypothalamus obviously. Permeability index followed a similar trend. Protein expression assays showed that borneol decreased the expression of Mdr1 and Mrp1 in hippocampus and hypothalamus. Further RT-PCR study showed that borneol decreased the expressions of both Mdr1a and Mdr1b in hippocampus and hypothalamus. The pharmacokinetics study demonstrated that the delivery of borneol in cortex was the most and that in striatum the least, with the deliveries of borneol in hippocampus and hypothalamus in between.Borneol showed tissue specific BBB-opening effect, which was associated with its regulation of the ultrastructure of brain tissues and the expressions of Mdr1a, Mdr1b and Mrp1. The present study indicated that borneol should be used in concert with drugs targeting hippocampus or hypothalamus to exert its synergistic effect to the maximum.",
        "keywords": [
            "blood-brain barrier",
            "tissue specific",
            "borneol",
            "ultrastructure",
            "atp-binding cassette proteins"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": ""
            },
            {
                "name": "Ruan Ming",
                "org": ""
            },
            {
                "name": "Dong Xiaoping",
                "org": ""
            },
            {
                "name": "Yu Yun",
                "org": ""
            },
            {
                "name": "Cheng Haibo",
                "org": ""
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2013
    },
    "MsRrvoaB": {
        "id": "MsRrvoaB",
        "title": "Teaching Experience and Strategy of Pharmacology of TCM in Traditional Chinese Medicine",
        "abstract": "To research the difficult in Pharmacology of TCM teaching and expound the experience in the process.Adopting different teaching methods according to students with different foundation.In addition,other strategies have been used for the characteristics of large amount of information and experiments.Students have enhanced the study interests and grasped more study content.The new teaching method has shown a better study effect.",
        "keywords": [
            "Teaching",
            "Strategy",
            "Pharmacology of TCM"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Pharmacy college, Nanjing University of Traditional Chinese Medicine, Nanjing , China"
            },
            {
                "name": "Lu Jinfu",
                "org": "Pharmacy college, Nanjing University of Traditional Chinese Medicine, Nanjing , China"
            },
            {
                "name": "Xu Huiqin",
                "org": "Pharmacy college, Nanjing University of Traditional Chinese Medicine, Nanjing , China"
            },
            {
                "name": "HONG Min",
                "org": "Pharmacy college, Nanjing University of Traditional Chinese Medicine, Nanjing , China"
            },
            {
                "name": "HUA Yongqing",
                "org": "Pharmacy college, Nanjing University of Traditional Chinese Medicine, Nanjing , China"
            }
        ],
        "venue": "Chinese Medicine Modern Distance Education of China",
        "year": 2013
    },
    "fuLZWsz3": {
        "id": "fuLZWsz3",
        "title": "Electro-acupuncture at Housanli(ST36) promotes the absorption of tanshinone ⅡA",
        "abstract": "BACKGROUND:In recent years,a large number of studies have shown that acupuncture combined with medication can synergy to improve myocardial ischemia,but the mechanism of this treatment has not been clarified.OBJECTIVE:To observe the effects of electro-acupuncture of Housanli(ST36) in combination with oral doses of Salvia(varying concentrations) in the prevention of myocardial ischemia,and to observe the levels of tanshinone ⅡA in the blood and in myocardial muscle tissues after treatment.METHODS:SD rats were randomly divided into the sham-surgery,model,low-and high-dose drug,and low-and high-dose drug + acupuncture groups.Electro-acupuncture was given on Housanli(ST36) in the adult SD rats following intragastric administration of 0.1 or 0.2 mg/L Danshen decoction.The changes of electrocardiogram T wave,heart and serum lactate dehydrogenase(LDH),and creatine kinase(CK) were observed after intragastric administration.HPLC was used for observation of tanshinone ⅡA concentrations in serum and cardiac tissues.RESULTS AND CONCLUSION:Electro-acupuncture combined with different concentrations of Dansen decoction could protect the damage caused by myocardial ischemia by reducing the level of T wave and related enzymes.The content of Tanshinone ⅡA in the blood in the low dose and acupuncture group was higher than that in the low dose group in the same period(P < 0.05),but the content of Tanshinone ⅡA in the heart tissue in the low-dose + acupuncture group was not higher than that in the low-dose group(P > 0.05).Electro-acupuncture can promote the drug absorption in the low drug concentration,this role is mainly to promote the improvement of blood concentration,but does not increase the drug concentration on the target organ.Electro-acupuncture can promote drug absorption,thus,increasing the efficacy of the drug.",
        "keywords": [],
        "authors": [
            {
                "name": "Li Zhong-han",
                "org": "Key Provincial-level Laboratory of Integrative Acupuncture and Drugs,Ministry of Education,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Huang Lun",
                "org": "Jiangsu Provincial Key Laboratory of the Evaluation of Efficacy and Safety,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Liu Li-wei",
                "org": "Key Provincial-level Laboratory of Integrative Acupuncture and Drugs,Ministry of Education,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Lu Jia",
                "org": "Key Provincial-level Laboratory of Integrative Acupuncture and Drugs,Ministry of Education,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Yu Bin",
                "org": "Jiangsu Provincial Key Laboratory of the Evaluation of Efficacy and Safety,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Zhu Yi",
                "org": "Key Provincial-level Laboratory of Integrative Acupuncture and Drugs,Ministry of Education,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Xu Bin",
                "org": "Key Provincial-level Laboratory of Integrative Acupuncture and Drugs,Ministry of Education,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            },
            {
                "name": "Fang Tai-hui",
                "org": "Jiangsu Provincial Key Laboratory of the Evaluation of Efficacy and Safety,Nanjing University of Traditional Chinese Medicine,Nanjing ,Jiangsu Province,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2010
    },
    "gJdATusp": {
        "id": "gJdATusp",
        "title": "Influence of cyclovirobuxine D on intracellular [Ca(2+)] regulation and the expression of the calcium cycling proteins in rat myocytes.",
        "abstract": "Our previous studies have shown that cyclovirobuxine D (CVB-D) ameliorated the cardiac function in heart failure rats. Considering the relationship between cardiac function and [Ca(2+)]i, and the role of calcium cycling on regulating [Ca(2+)]i, the present study was designed to evaluate the influence of CVB-D on the calcium transient of myocytes from neonatal rats and adult heart failure (HF) rats. The expression of calcium cycling proteins, including L-type calcium channel (LTCC), ryanodine receptor 2 (RYR2), sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) and sodium-calcium exchanger (NCX), were investigated to explore the underlying mechanism. CVB-D increased the intensity of calcium transient, accelerated the process of calcium transient and attenuation in the neonatal and adult myocytes. Furthermore, CVB-D shortened T(peak) and T(attenuation) in the adult myocytes and slowed down the heart rate of neonatal myocytes. Besides, CVB-D increased the expression of RYR2 and SERCA2a, decreased the expression of NCX, but showed no significant effect on LTCC. Thus, it was concluded that CVB-D increased the release and uptake of Ca(2+) in systolic and diastolic period, respectively. CVB-D might not only facilitate the utilization of intracellular Ca(2+), but also prevent the loss of Ca(2+).",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu, PR China. nzyyubin@163.com"
            },
            {
                "name": "Ming Ruan",
                "org": ""
            },
            {
                "name": "Lingling Zhou",
                "org": ""
            },
            {
                "name": "Li Xu",
                "org": ""
            },
            {
                "name": "Taihui Fang",
                "org": ""
            }
        ],
        "venue": "Fitoterapia",
        "year": 2012
    },
    "YLbPyukC": {
        "id": "YLbPyukC",
        "title": "Effect of electroacupuncture intervention on expression of ATP-binding cassette protein and gene in the cerebral cortex of depression rats]",
        "abstract": "To observe the effect of electroacupuncture (EA) on the expression of blood-brain barrier (BBB)-related functional protein, ATP-binding cassette protein and gene in the cerebral cortex of depression rats.Forty SD rats were equally and randomly divided into control group, EA group, depressive (model) group and depression + EA group. The depression model was established by chronic unpredictable mild stress. EA (2 Hz, 1 mA) was applied to \"Baihui\"(GV 20) and \"Yamen\"(GV 15) for 20 min, once daily for 14 days. The expression levels of multidrug resistance (Mdr) 1a, Mdr 1b, multidrug resistance-associated protein (Mrp) 1, Mrp 4, Mrp 5, and breast cancer resistance protein (Bcrp) gene and proteins in the cerebral cortex tissue were detected by RT-PCR semi-quantitative analysis and Western blot, respectively.In comparison with the control group, no obvious changes were found in the expression levels of cerebral Mdr la, Mdr 1b, Mrp 1, Mrp 4, Mrp 5 and Bcrp genes and proteins in the model group (P > 0.05), and only cerebral Mdr 1a gene and protein expression levels in the EA group were evidently down-regulated (P < 0.01, P < 0.05). Compared with the model group, only cerebral Mdr la gene and protein expression levels were obviously decreased in the depression+ EA group (P < 0.01, P < 0.05). No significant changes were found in the Mdr 1b, Mrp 1, Mrp 4, Mrp 5 and Bcrp genes and proteins after EA intervention in depression rats (P > 0.05).EA of GV 20 and GV 15 can obviously down-regulate the expression of cerebral Mdr 1a in depression rats which might be involved in the opening activity of blood-brain barrier.",
        "keywords": [
            "depression",
            "atp-binding cassette transporter",
            "electroacupuncture",
            "blood-brain barrier",
            "cerebral cortex"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Ming Ruan",
                "org": ""
            },
            {
                "name": "Yong Sun",
                "org": ""
            },
            {
                "name": "Jun Long",
                "org": ""
            }
        ],
        "venue": "Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji]",
        "year": 2013
    },
    "P2kepBJI": {
        "id": "P2kepBJI",
        "title": "Research on Activity-based Intergrated Modeling Method for Operational Requirements of C~4ISR System",
        "abstract": "Based on synthetically analyzing the DoDAF Operational View Products,an activity-based and information centric method is lucubrated for the integrated modeling of the operational requirements of the C4ISR system.Firstly,utilizing the extended-mechanism,including stereotypes,tagged-values and constraints,the metamodel for the integrated modeling is established.Secondly,the minimum core elements collection is established by Object-Oriented method and each element with their association is deeply analysed.At last,based on the above,an exploiture framework is definituded for the integrated modeling of the operational requirements of the C4ISR system,which provides the guidance for the process of the integrated modeling of the operational requirements.",
        "keywords": [
            "information",
            "node",
            "operational requirements",
            "activity",
            "DoD architecture framework"
        ],
        "authors": [
            {
                "name": "RAO De-hu",
                "org": "The National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "The National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "DUAN Cai-Yu",
                "org": "The National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZOU Yun",
                "org": "The National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2007
    },
    "le7jtnMV": {
        "id": "le7jtnMV",
        "title": "Framework for Modeling C~4ISR Requirements",
        "abstract": "There has been no mature model for expressing needs and expectations of people within the area of national defense,and it is considered as the most important business in C4ISR requirement analysis.In order to cope with this problem,an approach has been put forward in the paper.Firstly,basic concepts were analyzed,the concept of C4ISR requirement system was put forward based on concept analysis,and the idea of modeling C4ISR requirements was presented.Secondly,elements of C4ISR requirements model were studied. Metaclasses in the domain of C4ISR requirements and relationships among the metaclasses were distilled and defined.Therefore,C4ISR requirements models were designed on purpose to solve C4ISR requirement problems.Lastly,the paper provides the process of modeling C4ISR requirements based on element analysis. What C4ISR requirement models require and how to build the models are clarified.The approach elaborates what the real C4ISR requirements are and it can serve as the guideline of modeling C4ISR requirements.",
        "keywords": [
            "requirements model",
            "element",
            "C4ISR",
            "requirements"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "College of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Wei-ming",
                "org": "College of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of National University of Defense Technology",
        "year": 2007
    },
    "wcnUJEHG": {
        "id": "wcnUJEHG",
        "title": "Analyzing and Modeling of Operational Activities",
        "abstract": "Operational function is the capability which operational node has performing operational activities.And operational task causes operational node to perform operational activities.Firstly,this paper introduces some basic concepts,for example operational node,operational task,operational function,and operational activity.Secondly,the relation among operational task,operational function and operational activity is analyzed.Then the model is built.If to chose \"f\" for \"function\",\"t\" for \"task\",and \"a\" for \"activity\",the relationship can be denoted as \"a=A(f,t)\",which means that operational activities that an operational node performs are restricted by operational function and operational task all together.Based the mathematical relationship model,relational matrix is built.Operational activities are shown and analyzed comprehensively in a matrix format.Lastly,the paper presents the process for analyzaing and obtaining operatinal activity,in which IDEE0 model is used.",
        "keywords": [
            "operational activity",
            "C~4ISR",
            "operational node",
            "operational task",
            "architecture",
            "operational function"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Yang Xiao-ming",
                "org": "National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LIU Jian-feng",
                "org": "National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2006
    },
    "xFoXMoZS": {
        "id": "xFoXMoZS",
        "title": "Study on the Transition Methods from Conceptual Model of Military Simulation to Component Model",
        "abstract": "There are many factors in the battle process.It is essential to transform the static conceptual model of military simulation to reusable simulation model.Therefore,the transition methods from conceptual model of military simulation to component model are presented.Firstly,the descriptions and formal definitions of conceptual model of military simulation and component model are developed.Secondly,the transition framework and transition process from conceptual model of military simulation to component model are brought forward.Last,the city air defense has been taken as an example to illustrate the transition methods.",
        "keywords": [
            "conceptual model of military simulation component model transition methods"
        ],
        "authors": [
            {
                "name": "LI Ran",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,P.R.China"
            },
            {
                "name": "YU Bin",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,P.R.China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,P.R.China"
            },
            {
                "name": "YUAN Zhi-min",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2008
    },
    "bf70eeDq": {
        "id": "bf70eeDq",
        "title": "Reference model and formal analysis for requirements of equipment systems",
        "abstract": "In order to clarify what requirements of equipment systems should be,a reference model is brought forward,which focuses on the relations between equipment systems and the problems to be solved.By using the formulas of higher-order logic,the paper describes the relations to be satisfied by the military requirements of equipment systems and requirements specification,and the propositions of adequateness and necessity are also included.The necessity of military requirements merits some appreciation so as to avoid the interference of wrong properties.The necessity of requirements specification gives direct responsibilities to the military and technical workers,and helps them to divide the work.Finally,proof obligations are discussed and verified.The analysis shows that the proof obligations are consistent and feasible.",
        "keywords": [
            "requirement",
            "specification",
            "necessity",
            "reference model",
            "adequacy",
            "equipment system"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "Coll.of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Wei-ming",
                "org": "Coll.of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "Coll.of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Jiu-cheng",
                "org": "Coll.of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Systems Engineering and Electronics",
        "year": 2009
    },
    "3stpQVgZ": {
        "id": "3stpQVgZ",
        "title": "Study of A Pattern for C~4ISR Requirements' Description",
        "abstract": "A correct and complete requirements definition is one foundation of requirements engineering,so it is essential to develop a pattern to describe C4ISR requirements.The pattern is composed of a series of technologies,constraints and productions.This paper first analyzes the structure of the C4ISR requirements documents and presents criterion of requirements description,then a series of components are designed by Object Oriented technology. Also,the reuse of components and requirements is studied.At last through organizing the technologies,constraints and productions,a description framework is presented.",
        "keywords": [
            "reuse",
            "pattern",
            "component",
            "requirements"
        ],
        "authors": [
            {
                "name": "SHI Jian-mai",
                "org": "The National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "The National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "SHA Ji-chang",
                "org": "The National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "The National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2007
    },
    "davWuX1P": {
        "id": "davWuX1P",
        "title": "Analysis on the Validity of C~3I System Requirement Guide Lines Based on Probability Influence Diagram",
        "abstract": "An analysis method based on Probability Influence Diagrams is put forward when the initial period of the C3I system construction aimed at a question-Does the target construction system proposed which by the correlation unit whether meet the operational mission requirement.Firstly the validity concept of requirement guide lines is defined.Then has carried on the analysis to the C2 process,the uncertainty factors were discovered in C2 process each link.Afterward found a analysis model of the validity of requirement guide lines based Probability Influence Diagrams.Finally has given the model test through the aerial defense example.",
        "keywords": [
            "validity",
            "probability influence diagram",
            "military requirement"
        ],
        "authors": [
            {
                "name": "ZHANG Yi-heng",
                "org": "1.National University of Defense Technology,Changsha ,China,"
            },
            {
                "name": "HE Ying",
                "org": "2.North Automatic Control Technology Institute,Taiyuan ,China"
            },
            {
                "name": "YU Bin",
                "org": "1.National University of Defense Technology,Changsha ,China,"
            }
        ],
        "venue": "Fire Control & Command Control",
        "year": 2011
    },
    "JO3No3tE": {
        "id": "JO3No3tE",
        "title": "A Pattern for Describing the Capabilities of Weapon System Based on Cognition",
        "abstract": "Actually the process of doing research on capabilities of weapon system is that realizing capability constantly through practice,and feeding back.Therefore,pattern of describing capabilities of weapon system based on cognition is put forward.Firstly,basic concepts are analyzed.Included are the capability of weapon system,capability element,capability atom,and capability property.Capability elements and capability atoms are all capabilities,into which the top capability is separated.Capability properties are the key attributes for analyzing capability atoms.Secondly,three dimensions model of describing capabilities of weapon system based on cognition is built.Notions of capability's pragmaticism,semantics,and syntax on cognition are presented.Pragmaticism and semantics show capability's significance.Syntax is the representation of pragmaticism and semantics.Thirdly,a framework based on cognition is designed on purpose to describe capabilities of weapon system.The integrants of the framework are pragmaticism analysis,semantics analysis,and syntax description.Lastly,an example shows that the pattern is highly helpful and feasible.",
        "keywords": [
            "pragmaticism",
            "syntax",
            "semantics",
            "weapon system",
            "capability"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "1.College of Information System and Management,National University of Defense Technology,Changsha ,China,"
            },
            {
                "name": "HE Ying",
                "org": "2.North Automatic Control Technology Institute,Taiyuan ,China,"
            },
            {
                "name": "YE Jian-liang",
                "org": "3.Nanjing Army Command College,Nanjing ,China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "1.College of Information System and Management,National University of Defense Technology,Changsha ,China,"
            },
            {
                "name": "LIANG Guo-jiu",
                "org": "2.North Automatic Control Technology Institute,Taiyuan ,China,"
            }
        ],
        "venue": "Fire Control & Command Control",
        "year": 2010
    },
    "BIK4lmh7": {
        "id": "BIK4lmh7",
        "title": "Study on Operational Process Description based on Event Sequence",
        "abstract": "It is an important description method of operational process based on event sequence.The basic concept of event sequence is analyzed using formal method and clear and direct diagrammatic representation of event sequence is given.Basic idea on the operational process description method based on event sequence,which is combined with formal and diagrammatic representation,is proposed and the steps are given.And a simple example is given and its operational process is described using the proposed method.The method is proved to be effective through the example.",
        "keywords": [
            "formal method",
            "operational process description",
            "diagrammatic representation",
            "event sequence"
        ],
        "authors": [
            {
                "name": "YUAN Zhi-min",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "CAI Shan",
                "org": "College of Information System and Management,the National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2008
    },
    "oew48Ato": {
        "id": "oew48Ato",
        "title": "Analysis of Problem Frame and Properties Materiel Requirements",
        "abstract": "In order to extropolate what are involved in materiel requirements,problem frame for materiel requirements is provided and substantive properties which belong to materiel requirements are rigorously analyzed based on key artifacts,which are distilled from the wide variations in the use of terms.Problem frame for materiel requirements focuses on the key artifacts,their attributes,and relationships at a general level.By using higher-order logical notational conventions,formal analyses are made,describing the relations that material requirements and their reflection must satisfy.Adequacy,precondition,feasibility,necessity,and hierarchy of materiel requirements are included.Adequacy,necessity,and guidablity of materiel requirements reflection are also included.Finally,an example about the presumed urban antimissile defense system shows that the approach is highly feasible,effective and promising.",
        "keywords": [
            "Key artifacts",
            "Materiel requirements",
            "Materiel requirements reflection",
            "Problem frame",
            "Weapon materiel"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "College of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Wei-ming",
                "org": "College of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of National University of Defense Technology",
        "year": 2009
    },
    "Lo3FKynA": {
        "id": "Lo3FKynA",
        "title": "Research on the Concept of C~4ISR Requirements Process",
        "abstract": "It is considered to have been finished with C4ISR requirements only when it has achieved a clear,stable understanding of what are needed.However,nowadays the results of C4ISR requirements analysis are dissatisfactory.Therefore,the authors put forth the idea of C4ISR requirements process,which can serve as the guideline of the activities in C4ISR requirements engineering.Firstly,considering operational domain,functional domain and technical domain,C4ISR requirements are divided into three layers,including capacity requirements,system requirements and technical requirements.Secondly,the authors present the definition of C4ISR requirements process and delineate the framework of C4ISR requirements process.The framework is composed of requirements domain,requirements development and requirements management.C4ISR requirements development is the set of activities including gathering,modeling,verifying and generating requirements.C4ISR requirements management is the set of activities including managing relations,managing changes and managing editions.Lastly,the authors analyze the functions of C4ISR requirements process provided that it is used in the life-cycle of C4ISR system.The analysis shows that tC4ISR requirements process is very important.",
        "keywords": [
            "process",
            "development",
            "C4ISR",
            "management",
            "requirements"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "1.School of Information System and Management,National University of Defense Technology,Changsha ,China,"
            },
            {
                "name": "WU Jing",
                "org": "2.College of Basic Education for Commanding Officers,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Wei-ming",
                "org": "1.School of Information System and Management,National University of Defense Technology,Changsha ,China,"
            },
            {
                "name": "YU Bin",
                "org": "1.School of Information System and Management,National University of Defense Technology,Changsha ,China,"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2009
    },
    "RhREAgE6": {
        "id": "RhREAgE6",
        "title": "Research on Planning and Developing Subject about Military Requirements Engineering",
        "abstract": "A military requirement is a necessary attribute in the military system. Military requirement engineering,which belongs to military operational research,involves a set of activities for guoranteeing the validity of military system,including gathering requirements,making requirements understandable,specifying requirements,and so on. Some problems about planning and developing the subjects about military requirements engineering are studied. Included are subject plan,teaching contents and computer aided education. Teaching contents comprise methodology,technology and application. Computer aided education should adapt well to the curriculum. The authors suggest that the educational concepts should orient to the needs of Information-based warfare and new theories and technologies,which appear in the research,should be included.",
        "keywords": [
            "military requirement engineering",
            "plan",
            "develop"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "Coll. of Information system and management,NUDT,Changsha "
            },
            {
                "name": "CHEN Chao",
                "org": "Coll. of Information system and management,NUDT,Changsha "
            },
            {
                "name": "YU Bo-chao",
                "org": "Unit 92724 of PLA,Qingdao ,China"
            },
            {
                "name": "YU Bin",
                "org": "Coll. of Information system and management,NUDT,Changsha "
            }
        ],
        "venue": "Journal of Higher Education Research",
        "year": 2010
    },
    "PWjROcbD": {
        "id": "PWjROcbD",
        "title": "Evaluation Method of Groupped Variable Weight Sgnthesizing and its Application",
        "abstract": "On the basis of analyzing the method of variable weight sgnthesizing for decision-making,the variable weight analyse theory is introduced to the decision making of multi-project and multi-index evaluation,and then the method of groupped variable weight sgnthesizing is present.In the end,and an example is given to note the groupped ariable weight principle.",
        "keywords": [
            "groupped",
            "variable weight sgnthesizing",
            "evaluation"
        ],
        "authors": [
            {
                "name": "CHEN Chao",
                "org": "School of Information System and Management,Univ.of National Defense Technology,Changsha ,China"
            },
            {
                "name": "SHA Ji-chang",
                "org": "School of Information System and Management,Univ.of National Defense Technology,Changsha ,China"
            },
            {
                "name": "LIU Jun-xian",
                "org": "School of Information System and Management,Univ.of National Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Information System and Management,Univ.of National Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Systems & Management",
        "year": 2007
    },
    "8xmoUT4n": {
        "id": "8xmoUT4n",
        "title": "Review of the research on military requirements engineering",
        "abstract": "A requirement is a necessary attribute in a system.It is also a statement that identifies a capability,characteristic,or quality factor of a system in order that it is valuable and practical to a user.Military requirements engineering(MRE) involves the set of activities of ensuring the validity of military system,including gathering requirements,correcting requirements,and specifying requirements.In order to advance the research on MRE and improve the mechanism of military requirements generation,a review of the research on MRE is put up.The state-of-art of MRE is introduced in terms of military requirements development,military requirements management,military requirements verification and validation.And the methods and technologies are discussed.Related achievements and practical application are analyzed and summarized.The research indicates that the direction in MRE development is practicability,standardization and institutionalization.",
        "keywords": [
            "verification and validation",
            "requirements engineering",
            "military requirements",
            "development",
            "management"
        ],
        "authors": [
            {
                "name": "DUAN Cai-yu",
                "org": "School of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Wei-ming",
                "org": "School of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "SHI Jian-mai",
                "org": "School of Information System and Management,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Systems Engineering and Electronics",
        "year": 2007
    },
    "wNHJ9VU0": {
        "id": "wNHJ9VU0",
        "title": "Research on System Capabilities Integration and Development based on SCFP Model",
        "abstract": "The developing of materiel system will be more fit for future war by materiel system planning based on capabilities analysis.The interrelated concepts of the System Capabilities Integration and Development(SCI&D)are discussed.After SCFP Model is presented,a method of the SCI&D based on SCFP Model is studied,the core of the method is to study the mapping among the domain of the system CFP.The generic process of the SCI&D is presented,and a spy satellite application system is taken as a simple example to illustrate how system capabilities integration executes based on SCFP model.",
        "keywords": [
            "SCI&D",
            "SCFP model",
            "system capabilities",
            "mapping",
            "key performance parameters"
        ],
        "authors": [
            {
                "name": "MA Guo-pu",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "SHA Ji-chang",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2008
    },
    "VjNqZXRW": {
        "id": "VjNqZXRW",
        "title": "A Method for Analyzing Equipment Requirements based on Value",
        "abstract": "The value is the precondition of equipment requirements analysis.There has been no mature model for expressing needs and expectations of people within the area of national defense until recently,which is the most important business in equipment requirements analysis.In order to cope with these problems,an approach of analyzing equipment requirements based on VFT(Value-Focused Thinking) has been put forward in this paper.Firstly,characteristics of equipment requirements are analyzed,and the idea of equipment requirements system is presented.Secondly,value model of equipment requirements are distilled based on equipment requirements system.And the models used for describing equipment requirements are presented.Lastly,the paper puts forward with the process of analyzing equipment requirements based on value.The approach facilitates getting to the real equipment requirements.And it can serve as the guideline of modeling equipment requirements.",
        "keywords": [
            "weapon equipment",
            "model",
            "value-focused thinking",
            "value",
            "requirements"
        ],
        "authors": [
            {
                "name": "ZHANG Yong",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WU Xiao-yue",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2008
    },
    "jMF7AR4k": {
        "id": "jMF7AR4k",
        "title": "A Framework Model for the Development of Military Requirement of the Equipment System based on the Perspectives",
        "abstract": "The Framework model for the Development of Military Requirement of the Equipment System provides the guidance and rules for developing the Military Requirement of Equipment System.Considering the complexity of sysyem and the diversity of developers,for reflecting the perspectives's requirements,this paper uses the method of perspectives for analysing Military Requirement,firstly.And then the framework model for development of military requirement is constructed based on the method.Thirdly,the military requirement System of Equipment System is analysed.Lastly,this paper gives an example to elucidate the practicability of this framework.",
        "keywords": [
            "framework for the development of military requirement",
            "role",
            "perspective",
            "military requirement"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "YU Jiu-cheng",
                "org": ""
            },
            {
                "name": "DUAN Cai-yu",
                "org": ""
            },
            {
                "name": "YU Bo-chao",
                "org": "2.Navy Aeronautical Engineering Institute,Yantai ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2009
    },
    "x1U7AOJk": {
        "id": "x1U7AOJk",
        "title": "Investigation of Some Problems about the Teaching of Military Operational Research for Military Engineering Master",
        "abstract": "In order to further improve the quality of the talent of military engineering master, the authors analyze the characteristics of military engineering master and discuss some problems about teaching of military operational research for military engineering master. Firstly, the authors point out that the teaching concepts must be renovated. Military teaching concepts should meet the needs in the 21st century. Secondly, the authors suggest that teaching methods should be based on the students and adapt well to the curriculum. Last, the authors propose that teaching content must be updated. To achieve this aim, new theories and technologies which emerge in the research about military high-technology should be included.",
        "keywords": [
            "military engineering Master",
            "Military Operational Research",
            "teaching patterns"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Information system and management,NUDT,Changsha ,China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "College of Information system and management,NUDT,Changsha ,China"
            }
        ],
        "venue": "Journal of Higher Education Research",
        "year": 2008
    },
    "fMngsOFN": {
        "id": "fMngsOFN",
        "title": "Study on Catch Probability Model and Simulation of the Anti-ship Missile in Two Shoot Methods for BVR Attacking",
        "abstract": "For BVR attacking,different shoot methods would have important influence to the catch probability of anti-ship missile.Based on analyzing the mechanism of accuracy on the condition of two different shoot methods,the catch probability models of anti-ship missile terminal guidance radar of two shoot methods for BVR attacking are presented.Based on given parameters,the simulation is carried on and the difference of the two shoot methods is given too.",
        "keywords": [
            "anti-ship missile",
            "catch probability",
            "BVR",
            "simulation"
        ],
        "authors": [
            {
                "name": "CHAO Chen",
                "org": "School of Information System and Management,National Univ of Defense Technology,Changsha ,China"
            },
            {
                "name": "SHA Ji-chang",
                "org": "School of Information System and Management,National Univ of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Information System and Management,National Univ of Defense Technology,Changsha ,China"
            },
            {
                "name": "MAO Chi-long",
                "org": "School of Information System and Management,National Univ of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2007
    },
    "qpxnJb40": {
        "id": "qpxnJb40",
        "title": "Research on the relevance of materiel requirements based on clustering using hierarchies",
        "abstract": "This paper used the mothod of clustering using hierarchies to study the relevance of materiel requirements.Firstly,materiel requirements were decomposed into three parts:fight requirements,system requirements,technology requirements.Then,this paper builded a matrix between fight requirements and system requirements and a matrix between system requirements and technology requirements by some rules which it made.Lastly,it got the correlative matrix between fight requirements and technology requirements by the operation of two matrixes.The results indicate that we can find the relevance of materiel requirements clearly through this method.",
        "keywords": [
            "electronic map",
            "relevance",
            "clustering using hierarchies",
            "materiel requirements"
        ],
        "authors": [
            {
                "name": "ZHUANG Jin-tao",
                "org": "Science and Technology on Information Systems Engineering Laboratory,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YU Bin",
                "org": "Science and Technology on Information Systems Engineering Laboratory,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LU Feng",
                "org": "Department of Training,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Electronic Design Engineering",
        "year": 2011
    },
    "x2L0I2Zt": {
        "id": "x2L0I2Zt",
        "title": "A Requirement-analysis-Oriented Classification of Military Systems and its Application",
        "abstract": "To analyze military requirements and do relevant scientific studies,military systems must been classified in particular.However,the taxonomies of systems are still in their early stages,which are not adaptive to military requirements analysis.Therefore,based on the characters of military requirements and evolutionary rules of military system,three-dimensional(3-D) taxonomy,in which military systems are classified according to three levels of task illegibility,three levels of structural complexity,and three levels of technological uncertainty,is put forward.Based on the premise that requirements analysis must be adaptive to the type of military system,it is suggested that military requirements analysis should comprise three grades.The grades are reproduction,discovery and creation.At last,the application is analyzed and shows that the method is highly feasible.",
        "keywords": [
            "structure",
            "technology",
            "task",
            "military systems",
            "requirements analysis"
        ],
        "authors": [
            {
                "name": "DUAN Cai-Yu",
                "org": "College of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Yu Bin",
                "org": "College of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Wei-ming",
                "org": "College of Information System and Management,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control & Command Control",
        "year": 2011
    },
    "Ea76pNAm": {
        "id": "Ea76pNAm",
        "title": "Hierarchy Description Process for Operational Node Connectivity",
        "abstract": "ONCD(Operational Node Connectivity Description) is one of the essential C~4ISR architecture products.Firstly,this paper discusses the hierarchy of operational mission,analyzes two types of functional decomposition——\"Mission-Mission\" and \"Mission-Task\".The paper studies \"Mission-Mission\" emphatically,and presents the complexity.It is concluded that it is inappropriate to complete Operational Node Connectivity Description immediately.Secondly, the paper studies the hierarchy of operational node.Operational node should be discomposed based on the hierarchy of operational node.Lastly,the paper presents Hierarchy Description Process for Operational Node Connectivity.",
        "keywords": [
            "C~4ISR",
            "operational node",
            "architecture",
            "hierarchy",
            "operational node connectivity description"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "DUAN Cai-yu",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "NIU Ling-yu",
                "org": "School of Information System and Management,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2006
    },
    "QrfcwnrL": {
        "id": "QrfcwnrL",
        "title": "Effect of different time to IUI after using hCG on pregnancy rate",
        "abstract": "Objective: To probe the effect of urinary LH on deciding the best time for intrauterine insemination(IUI) in induced ovulation.Methods: According to leading follicular size or according to both leading follicular size and the character of urinary LH to decide the different timing of IUI,the relationship between pregnancy rate and the timing of IUI as well as the cause of different pregnancy rate were analyzed. Results: There were 54 pregnancy cases in 227 cycles of 195 cases who underwent IUI treatment in our hospital.The pregnancy rate was 23.8% in every cycle.The pregnancy rate is 27.7% in every case.The pregnancy rate of the group undetected urinary LH was 17.3%,which significantly decreased in detected group(29.0%,28.3%)(P<0.05).The ovulation rulation rate of the group undetected urinary LH was(34.7%) in 24 hours after IUI,which decreased in the group detected urinary LH(50.7%,51.7%).(P<(0.05)) In the same time the pregnancy rate of each group was 38.2%,37.1% and 32.3%.There was not significant different in any of them. Conclusion: It was an important index for choosing the best timing of IUI that the leading follicular size combine the character of urinary LH.The best timing of IUI was before ovulation and the closer to it the better.The best timing of IUI was both 24 hours after urinary LH showed positive and 36 hours after injected HCG in the case whose urinary LH showed negative.",
        "keywords": [
            "human growth hormone",
            "pregnancy",
            "intrauterine insemination"
        ],
        "authors": [
            {
                "name": "CHEN Li",
                "org": "Changzhou Obstetrics and Gynecology Hospital,Changzhou Jiangsu ,China"
            },
            {
                "name": "XU Pei-zhen",
                "org": "Changzhou Obstetrics and Gynecology Hospital,Changzhou Jiangsu ,China"
            },
            {
                "name": "YANG Hai-yan",
                "org": "Changzhou Obstetrics and Gynecology Hospital,Changzhou Jiangsu ,China"
            },
            {
                "name": "YU Bin",
                "org": "Changzhou Obstetrics and Gynecology Hospital,Changzhou Jiangsu ,China"
            }
        ],
        "venue": "Journal of Jiangsu University(Medicine Edition)",
        "year": 2006
    },
    "P7SGqTFV": {
        "id": "P7SGqTFV",
        "title": "Examination of TSGF and its role in cell proliferation in carcinoma of endometrium",
        "abstract": "Objective:To estimate the clinical value of tumor specific growth factor(TSGF) in the diagnosis and monitoring of carcinoma of endometrium.Methods:The level of TSGF of the patients of carcinoma of endometrium and the content of DNA in tumor cell were detected.Results:① The level and the positive rate of TSGF for carcinoma of endometrium was significantly higher than that in other group(P<0.05).The sensitivity and specificity were 64.9% and 62.5%.②The SPF and PI raised in the patients whose TSGF were electropositive,higher than those of the women whose TSGF were negative.They were parallel.Conclusion:Serum TSGF level is helpful in diagnosis of carcinoma of endometrium,and related with the cell proliferation.",
        "keywords": [
            "PI",
            "SPF",
            "DNA",
            "Tumor specific growth factor",
            "Carcinoma of endometrium"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ",et al.Maternity and Infant Health Hospital of Changzhou,Changzhou ,Jiangsu,China"
            },
            {
                "name": "XU Pei-Zhen",
                "org": ",et al.Maternity and Infant Health Hospital of Changzhou,Changzhou ,Jiangsu,China"
            },
            {
                "name": "WU Xian",
                "org": ",et al.Maternity and Infant Health Hospital of Changzhou,Changzhou ,Jiangsu,China"
            }
        ],
        "venue": "Maternal and Child Health Care of China",
        "year": 2007
    },
    "hul1jkDL": {
        "id": "hul1jkDL",
        "title": "The effect of IL-1 on the expression of proliferation factor of micromodules in interstitial cell of endometrial",
        "abstract": "【Objective】 To probe the effect of IL-1 on the dynamic equilibrium between VEGF and ENS and to study the paroxysm of endometioma at molecular level.【Method】 The interstitial cells were separated from endometrial and cultivated alone,and added different-potency IL-1 to the descents,collected different-period culture media,and to test the expression of IL-8,VEGF and ENS by means of ELISA.Meanwhile,immunohistochemistry tow-step procedure was used to test the cultivated cells and ascertain the purity of these cultivated cells.【Results】 In the case of endometioma,the sensibility of eutopic endometrial interstitial cells under the conditions of IL-1 increased;therefore high-tone IL-8 and VEGF came into being(P <0.01).Under the conditions of a certain-dense IL-1,the expression of IL-8 and VEGF increased with the time extension,which depended on time.The expressions of IL-8 and VEGF under the conditions of different-dense IL-1 depended on the dosage of IL-1.In the case of endometioma,the expression of ENS in the eutopic endometrial culture media,under the conditions of IL-1,had no obvious difference from the normal control group;moreover,the expression of ENS was not related to the change of time or dense of IL-1 at all.【Conclusion】 In the case of endometioma,the expression of IL-8 and VEGF ineutopic endometrial interstitial cells becomes strong under the conditions of IL-1;While the expression of ENS doesn't change obviously.It is the imbalance of angiogenesis.That leads to active growth of endometrial vascellum,which may be one paroxysm of the disease.",
        "keywords": [
            "interleukin-1",
            "angiogenenesis imbalance",
            "endometioma",
            "proliferation of micromodules"
        ],
        "authors": [
            {
                "name": "CHEN Li",
                "org": "Key Laboratories of Reproductive Health,Changzhou Maternal and Child Care Hospital,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "WANG Qiu-wei",
                "org": "Key Laboratories of Reproductive Health,Changzhou Maternal and Child Care Hospital,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "YU Bin",
                "org": "Key Laboratories of Reproductive Health,Changzhou Maternal and Child Care Hospital,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "XU Pei-zhen",
                "org": "Key Laboratories of Reproductive Health,Changzhou Maternal and Child Care Hospital,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "LIU Jia-yin",
                "org": ""
            }
        ],
        "venue": "China Journal of Modern Medicine",
        "year": 2012
    },
    "6QGRETl3": {
        "id": "6QGRETl3",
        "title": "Establishing of cell model of adenomyosis in vitro",
        "abstract": "[Objective] To explore a method d isolating and culturing eutopic endometrial stromal cells,providing an in vitro cell model of adenomyosis for study of its mechanism.[Methods] Enzymolysis,filtration,sedimentation and pasted wall purification were used to isolate and culture stromal cells in 12 eutopic endometrium (not including hysteromyoma) pa- tients.[Results] The endometrial cell culture was successfully established in 9 of 12 adenomyosis samples,and the stromal cells could be transferred.The purity of stromal cells was more than 95%.[Conclusion] The isolation and culture of eu- topic endometrial stromal cells can serve as an in vitro experimental modle.",
        "keywords": [
            "stromal cells",
            "endometrium",
            "cell model",
            "adenomyosis"
        ],
        "authors": [
            {
                "name": "LIU Chun-ling",
                "org": "Maternity and Infant Health Hospital of Changzhou,Changzhou ,P.R.China"
            },
            {
                "name": "CHEN Li",
                "org": "Maternity and Infant Health Hospital of Changzhou,Changzhou ,P.R.China"
            },
            {
                "name": "XU Pei-zhen",
                "org": "Maternity and Infant Health Hospital of Changzhou,Changzhou ,P.R.China"
            },
            {
                "name": "YU Bin",
                "org": "Maternity and Infant Health Hospital of Changzhou,Changzhou ,P.R.China"
            }
        ],
        "venue": "Shandong Medical Journal",
        "year": 2007
    },
    "gmF2rqMa": {
        "id": "gmF2rqMa",
        "title": "Role of Serum S-100B Concentration in Diagnosis of Hypoxic-Ischemic Encephalopathy in Newborn Infants",
        "abstract": "Objective To explore the role of serum S-100B concentration of umbilical cord blood and blood on the 24 h after admission in the early diagnosis and development of newborn hypoxic-ischemic encephalopathy(HIE).Methods Forty-six HIE newborns(31 cases with mild HIE and 15 cases with moderate and severe HIE)were selected as HIE group,and 43 normal full-term newborns were selected as control group.The umbilical cord blood sample and blood sample were aquired on the 24 h after admission.The serum S-100B concentration was detected by enzyme-linked immunosorbent assay(ELISA)analysis.Results 1.There was no significant difference of serum S-100B concentration between the male sub-group and female sub-group of normal group and their birth weight had no significant relative to the serum S-100B concentration.2.The serum S-100B concentration of umbilical cord blood of control group and HIE group were(1.03±0.32)and(2.53±1.1)μg/L,respectively,there was significant difference between two groups(t'=8.848 P< 0.05).The serum S-100B concentration of umbilical cord blood of mild HIE group and moderate and severe HIE group were(1.03±0.32)and(3.49±1.23)μg/L respectively,they were significant difference among control group,mild HIE group and moderate and severe HIE group(F= 79.691 P<0.01).3.The serum S-100B concentration of blood on the 24 h after admission of control group and HIE group were(1.07±0.32)and(3.83±2.32)μg/L,respectively,there were significant difference between the two groups(t'=7.631 P< 0.05).The serum S-100B concentration of blood on the 24 h after admission of mild HIE group and moderate and severe HIE group were(2.84±1.06)and(6.11±2.83)μg/L respectively,they were significant difference among control group,mild HIE group and moderate and severe HIE group(F=48.224 P<0.01).5.There was a significant relation between the serum S-100B concentration of umbilical cord blood and that of blood on the 24th after admission(r=0.6 177 P<0.001).Conclusions 1.Birth weight and sex have no significant relative to the serum S-100B concentration.2.Serum S-100B concentration of umbilical cord blood and blood on the 24 h after admission can be biomarkers for early diagnosis,development of newborn HIE,especially the serum S-100B concentration of umbilical cord blood.",
        "keywords": [
            "infant",
            "S-100B protein",
            "serum",
            "brain",
            "newborn",
            "hypoxic-ischemic encephalopathy"
        ],
        "authors": [
            {
                "name": "WANG Huai-yan",
                "org": "c.Perintal Room,Maternal and Child Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "c.Perintal Room,Maternal and Child Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "GAO Chun-yuan",
                "org": "c.Perintal Room,Maternal and Child Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "WANG Jin-xiu",
                "org": "c.Perintal Room,Maternal and Child Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "GUO Xi-rong",
                "org": "Pediatric Research Institute of Nanjing Medical University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Applied Clinical Pediatrics",
        "year": 2007
    },
    "xap7zRzL": {
        "id": "xap7zRzL",
        "title": "The significance of human papillomavirus DNA test and type specific distribution in cervical diseases",
        "abstract": "【Objective】 To assess the significance of high-risk human papillomavirus DNA test and type specific distribution in cervical diseases.【Method】 2 153 sexually active women were selected for high-risk human papillomavirus DNA test with HC2Ⅱ.And 342 cases of CIN were detected HPV gene types.【Results】 ①The overall HPV prevalence was 32.6%(701/2 153),with higher positive rates in cervical carcinoma and CIN(93.9% and 54.6%).②For women aged 40～59,the overall high-risk HPV prevalence was higher than those of other age group.③It was founded that high-risk HPV DNA increased with aggrevation of cervical diseases.④The order of high risk type-specific prevalence was 16,52,58 in CIN patients.⑤HPV 16,52,33 were the most types in CIN Ⅰ,while HPV 16,58,18 in CINⅡ and HPV 16,52,58 in CIN Ⅲ.⑥The multiple infection rate of HPV was 23.0%,and there was no significantly incidence trends in multiple HPV infection prevalence of CINⅠ,CINⅡ,CIN Ⅲ.【Conclusions】 High-risk HPV DNA test has high value in screening cervical diseases.HPV16 is still the most type that we should pay more attention to.",
        "keywords": [
            "cervix neoplasms",
            "DNA virus",
            "genetype",
            "human papillomavirus",
            "HCⅡ",
            "cervical intraepithelial neoplasia"
        ],
        "authors": [
            {
                "name": "ZHOU Hong",
                "org": "Department of Laboratory,The Maternity and Infant Health Hospital of Changzhou, Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "WANG Qiu-wei",
                "org": "Department of Laboratory,The Maternity and Infant Health Hospital of Changzhou, Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "ZHU Zi-qiang",
                "org": "Department of Laboratory,The Maternity and Infant Health Hospital of Changzhou, Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Laboratory,The Maternity and Infant Health Hospital of Changzhou, Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "XU Pei-zhen",
                "org": "Department of Laboratory,The Maternity and Infant Health Hospital of Changzhou, Changzhou,Jiangsu ,P.R.China"
            }
        ],
        "venue": "China Journal of Modern Medicine",
        "year": 2011
    },
    "DHiA7mke": {
        "id": "DHiA7mke",
        "title": "FSH modulates the expression of inhibin-alpha and the secretion of inhibins via orphan nuclear receptor NUR77 in ovarian granulosa cells: NUR77 R EGULATES I NHIBIN -A LPHA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yali hu",
                "org": ""
            },
            {
                "name": "peizhen xu",
                "org": ""
            },
            {
                "name": "guijun yan",
                "org": ""
            },
            {
                "name": "bin wang",
                "org": ""
            },
            {
                "name": "ningyuan zhang",
                "org": ""
            },
            {
                "name": "qinyuan he",
                "org": ""
            },
            {
                "name": "anyi dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "haixiang sun",
                "org": ""
            },
            {
                "name": "lijun ding",
                "org": ""
            }
        ],
        "venue": "Molecular Reproduction and Development",
        "year": 2013
    },
    "0SCWuLnA": {
        "id": "0SCWuLnA",
        "title": "Evaluation of the Human Fetal Ovarian Tissue Transplantation in Patients with Ovarian Amenorrhea",
        "abstract": "OBJECTIVE:To assess the effects of fetal ovarian tissue transplantation on ovarian amenorrhea.METHODS:Fetal ovary of theraputic abortion at 20 to 24 weeks of gestation was collected,which was saved by procedural fall temperature technique and cultured in RPM1640 after freeze-thawing.From January 2003 to August 2003,three cases were subjected to fetal ovarian tissue transplantation in our hospital.The indication included ovarian dysfunction(1 cases),ovarian dysgenesis(1 case) and bilateral salpingo-oophorectomy(1 case).RESULTS:The rate of living cells of the ovarian tissue was 85.4% after freezing preservation.The processes of germ cellular growth and development was observed in culture.Part of oogonia grew up primary follicles.After transplantation,the menstrual cycle recoved in 2 patients with(auto-ovary) and regularity ovulation was viewed in 1 cases of them.The menstrual cycle did not recove in the patient of bilateral salpingo-oophorectomy,but the level of E_2 was higher than before transplantation and the quality of life was significantly improved.CONCLUSION:Fetal ovarian tissue transplantation is an effective treatment for patients with ovarian amenorrhea.",
        "keywords": [
            "procedural fall temperature techique",
            "cryopreser-vation",
            "fetal ovarian",
            "tissue transplantation",
            "culture"
        ],
        "authors": [
            {
                "name": "XU Peizhen",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "WANG Qiuwei",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Changzhou ,China"
            },
            {
                "name": "DONG Yishan",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Changzhou ,China"
            }
        ],
        "venue": "Evaluation and Analysis of Drug-Use in Hospitals of China",
        "year": 2006
    },
    "a0lVTwHg": {
        "id": "a0lVTwHg",
        "title": "The Value of Co-examination of CA_(125) and Solubility Fas, Fas-L in Adenomyosis",
        "abstract": "Objective:To co-examine the serum level of CA125, sFas and sFasL in patients with adenomyosis, and to discuss the clinical value of sFas and sFasL in adenomyosis. Methods:By ECL and ELISA technique, we determined the serum level of CA125 , sFas and sFasL in 30 cases of adenomyosis, then compared with 20 cases of hysteromyoma. Results: (1) After operation, the level of CA125 , sFas and sFasL in adenomyosis were significantly decreased, but there was no significant difference in hysteromyoma. (2) Before opreration, the level of CA125 , sFas and sFasL in adenomyosis greatly increased. (3)5 days after operation, the level of CA125, and sFasL in adenomyosis still increased than those in hysteromyoma, but the level of sFas of both was similar. Conclusion: (1) There was relationship between serum sFas,sFasL and the occurrence and development of adenomyosis. (2) sFasL could be a new serum marker of the diagnosis of adenomyosis, and play more important role in the observation of curative effect and the relapse estimation of the adenomyosis.",
        "keywords": [
            "sFasL",
            "Adenomyosis",
            "sFas",
            "CA125"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": " The Maternity and Infant Health Hospital of Changzhou City in Jiangsu Province, Changzhou "
            },
            {
                "name": "XU Peizhen",
                "org": " The Maternity and Infant Health Hospital of Changzhou City in Jiangsu Province, Changzhou "
            }
        ],
        "venue": "Chinese Journal of Clinical Medicine",
        "year": 2006
    },
    "HfgEkKOI": {
        "id": "HfgEkKOI",
        "title": "Progress in study on vitrification of ovary",
        "abstract": "As an advanced method of cryopreservation,vitrification shows some advantages and its effect is approved delectable in cryopreservation of ovary(including oocyte and ovarian tissues),especially in cryopreservation of oocyte.Most investigators thought that vitrification may be the future of cryopreservation,because it can decrease formation of ice crystals in the cells and decrease the damage at the largest degree.But this technique is imperfect jet now and in the cryopreservation of oocyte and ovarian tissues,satisfactory effects are not achieved,there are still many problems need to be resolved, such as kind and concentration of cryoprotectants,process,carrier and so on.This article reviewed research status of vitrification of ovary.",
        "keywords": [
            "cryopreservation",
            "vitrification",
            "oocyte",
            "ovarian tissue"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Changzhou Municipal Maternal and Child Health Hospital,Jiangsu Changzhou ,China"
            },
            {
                "name": "XU Pei-zhen",
                "org": "Changzhou Municipal Maternal and Child Health Hospital,Jiangsu Changzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Woman and Child Health Research",
        "year": 2007
    },
    "XJzrYYki": {
        "id": "XJzrYYki",
        "title": "Relationship between Serum TSGF and Tumor Angiogensis,Invasion,Metastasis in Endometrium Carcinoma",
        "abstract": "Objective:To study the relationship between serum tumor specific growth factor(TSGF)level and tumor angiogen- sis,invasion,metastasis in endometrium carcinoma.Methods:We collected the blood of the patients with carcinoma of endome trium,and examined the level of TSGF,vascular endothelial growth factor(VEGF),matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9).then compared with hysteromyoma patients and healthy controls.Results:Statistical sig nificance of the levels of TSGF VEGF,MMP-2 and MMP-9 were found when endometrium cancer group was compared with control group(P<0.05).Compared with the patients ofhysteromyoma,the levels of TSGF,MMP-2 and MMP-9 were great- ly higher(P<0.05),but there was no significant difference in the level of VEGF(P>0.05).The levels of TSGF.MMP-2 and MMP-9 were similar between the hysteromyoma and normal group(P>0.05).Conclusion:Serum TSGF associated with MMP-2 and MMP-9 may work on tumor invasion and metastasis.It advance tumur angiogenesis as VEGF.and play a more im- portant role.",
        "keywords": [
            "Vascular endothelial growth factor",
            "Matrix metalloproteinase-9",
            "Tumor specific growth factor",
            "Carcinoma of endometrium",
            "Matrix metalloproteinase-2"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": " The Maternity and In fant Health Hospital of Changzhou City in Jiangsu Province,Changzhou "
            },
            {
                "name": "XU Peizhen",
                "org": " The Maternity and In fant Health Hospital of Changzhou City in Jiangsu Province,Changzhou "
            },
            {
                "name": "ZHANG Rong",
                "org": " The Maternity and In fant Health Hospital of Changzhou City in Jiangsu Province,Changzhou "
            },
            {
                "name": "WANG Qiuwei",
                "org": " The Maternity and In fant Health Hospital of Changzhou City in Jiangsu Province,Changzhou "
            },
            {
                "name": "ZHOU Hong",
                "org": " The Maternity and In fant Health Hospital of Changzhou City in Jiangsu Province,Changzhou "
            }
        ],
        "venue": "Chinese Journal of Clinical Medicine",
        "year": 2007
    },
    "RAEIRt8F": {
        "id": "RAEIRt8F",
        "title": "Clinical value of combined determination of TSGF and CA125 in the crcinoma of endometrium",
        "abstract": "Objective:To study the clinical value of tumor specific growth factor(TSGF)and CA125 in the diagnosis and monitoring of carcinoma of endometrium.Methods:We collected the peripheral venous blood of the patients wiht carcinoma of endometrium,and examined the levels of TSGF and CA125.Results:(1)The level and the positive rate of TSGF in carcinoma of endometrium were significantly higher than those in other group(P<0.05).The sensitivity and specificity were 64.9% and 62.5% resepectivily.(2)The sensitivity of combining TSGF with CA125 was 75.7%,and it was better than TSGF or CA125 alone.Conclusion:Serum TSGF level is helpful in the diagnosis of carcinoma of endometrium.Combined determination of TSGF and CA125 can improve the diagnostic sensitivity of carcinoma of endometrium.",
        "keywords": [
            "Tumor marks",
            "CA125",
            "Tumor specific growth factor",
            "Carcinoma of endometrium"
        ],
        "authors": [
            {
                "name": "WU Xian",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Jiangsu ,China"
            },
            {
                "name": "YU Bin",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Jiangsu ,China"
            },
            {
                "name": "WANG Qiu-wei",
                "org": "The Maternity and Infant Health Hospital of Changzhou,Jiangsu ,China"
            }
        ],
        "venue": "Modern Medicine & Health",
        "year": 2006
    },
    "tPVOWgaK": {
        "id": "tPVOWgaK",
        "title": "Clinical Value and Analysis of DNA Ploid in Gynecology Tumor Sufferers",
        "abstract": "Objective To discuss the clinical value of DNA ploid in gynecology tumor patients. Methods By FCM technique, we examined the content of DNA ploid in tumor cell in 78 gynecology tumor patients, and analyzed the proportion of each period in one cell cycle. Results Within gynecology tumor patients, the rate of exceptional content of DNA is 50.0%, the rate of heighten S period is 42.3%. The rate of the patients over 50 years is much higher (P<0.01), and adenocarcinoma higher than squamous carcinoma (P<0.05). The rate of carcinoma ovarii is the highest in three kinds of gynecology tumors. Along with the increase of pathobiology grade, the rate also displayed the ascending direction. Conclusion The analysis of DNA ploid in gynecology tumor patients can availably realize the instance of the cell multiplication and the degree of cancerous. It can be used in instructed the project of therapy and improving prognosis.",
        "keywords": [
            "Gynecology Tumor DNA ploid Flow cytometry"
        ],
        "authors": [
            {
                "name": "Zhang Rong",
                "org": ".The Maternity and Infant Health Hospital of Changzhou , Jiangsu "
            },
            {
                "name": "Xu Peizhen",
                "org": ".The Maternity and Infant Health Hospital of Changzhou , Jiangsu "
            },
            {
                "name": "Yu Bin",
                "org": ".The Maternity and Infant Health Hospital of Changzhou , Jiangsu "
            }
        ],
        "venue": "Public Medical Forum Magazine",
        "year": 2006
    },
    "1Zicbuap": {
        "id": "1Zicbuap",
        "title": "Preliminary research for the relevance on the concentration of complement factor B and Down's syndrome",
        "abstract": "【Objective】To explore the relationship between the concentration of complement factor B(CFB) and Down's syndrome.【Method】By using two-dimensional gel electrophoresis followed by MALDI-TOF-MS and database searching,the differential protein expression profile of maternal serum with between Down's syndrome group and normal pregnancy group was analyzed.The concentrations of CFB were measured with enzyme linked immunosorbent assay(ELISA) in 11 cases of maternal serum with Down's syndrome and 11 cases of neonatal serum with Down's syndrome.【Results】29 spots on two-dimensional gels with altered expression were found.CFB was notably up-regulated by 5.73(P<0.05).Compared with normal pregnancy group,the concentration of CFB of maternal serum with Down's syndrome group was significantly increased(466.8 ng/mL vs.293.5 ng/mL,P<0.05).On the other hand,the concentration of CFB of neonates with Down's syndrome group decreased conspicuously(174.3 ng/ mL vs.311.8 ng/mL,P<0.001).【Conclusions】The expression level of CFB may be related to Down's syndrome,which implied that abnormal expression of CFB in Down's syndrome may be one of the factors inducing mental retardation.",
        "keywords": [
            "complement factor B",
            "Down's syndrome",
            "proteomics"
        ],
        "authors": [
            {
                "name": "ZHANG Bin",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "HUANG Rui-ping",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "SHI Ye",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "CAO Fang",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "ZHANG Xiao-qing",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            },
            {
                "name": "WANG Qiu-wei",
                "org": "Department of Reproductive Health Laboratory,Changzhou Woman and Children Health Hospital affiliated to Nanjing Medical University,Changzhou,Jiangsu ,P.R.China"
            }
        ],
        "venue": "China Journal of Modern Medicine",
        "year": 2012
    },
    "8FEL6hxd": {
        "id": "8FEL6hxd",
        "title": "Discussion on the remained issues on CAPM",
        "abstract": "Capital Asset Pricing Model (CAPM) is one of the most important theoretical cornerstones of modern finance studies, but it has two great issues remained. First, the model assumes that market clearing means equilibrium directly, avoiding the question how to conduct market adjustment without market clearing according to CAPM. Second, the model does not consider the influence of different asset scales. It only takes into account the rate of returns. However, difference in scales may have impact on people's understanding of the relationship between risks and returns. This article analyzes the two issues through an example of numerical values, finding that CAPM differs before and after market clearing, and that different asset scales have much influence on the results of CAPM.",
        "keywords": [
            "Asset scale",
            "Capital Asset Pricing Model",
            "Market clearing",
            "Portfolio"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Research Institute of Marxism, Chinese Academy of Social Sciences, Beijing, "
            }
        ],
        "venue": "Economist",
        "year": 2009
    },
    "9C3bEpFY": {
        "id": "9C3bEpFY",
        "title": "Query of the Fiscal Policy of Keynesianism",
        "abstract": "After the American Financial Crisis,Keynesianism rises again in the main capitalist countries of the world.However,Keynes's theory in his masterpiece The General Theory of Employment Interest and Money is untenable and a typical example is multiplier model.In fact,Keynes's multiplier model is only a result of inverted cause and effect and confuses two different kinds of income and investment relationships.Therefore,the essence of Keynes's multiplier is not that multiplier equals output variance divided by investment variance,but that multiplier equals output variance divided by unconsumed output variance,namely,it only shows how much is unconsumed in the output.The fiscal policy of Keynesianism which is based on a wrong theory can only be effective accidentally in rare circumstances.",
        "keywords": [
            "multiplier model",
            "income",
            "macro-economics",
            "Keynes",
            "investment"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Research Institute of Marxism,Chinese Academy of Social Sciences,Beijing ,China"
            }
        ],
        "venue": "Economic Survey",
        "year": 2009
    },
    "bwmK6pUE": {
        "id": "bwmK6pUE",
        "title": "On the Relation between Investment Transfer and Industrial Transfer and the Influence on Trade Surplus",
        "abstract": "The investment transfer is the behavior of the investors who invest for profit in other regions,industries or enterprises.Usually,this kind of behavior is accompanied with the inter-region or inter-industry capital flow which is demonstrated as investment transfer,trade transfer,technology transfer or overseas listing.The process of investment transfer is usually accompanied with industrial transfer;the industrial transfer and investment transfer is in the same direction;but industrial transfer is not the absolute result of investment transfer.Sometimes even if there is the industrial transfer accompanied with investment transfer,their directions are opposite with each other.The U.S.trade deficit with China is only the result of that the U.S.can not invest the huge capital into their own domestic market.And this result can not be eliminated by the appreciation of RMB,because it is not the result of RMB depreciation.",
        "keywords": [
            "investment transfer",
            "trade surplus",
            "industrial transfer",
            "the exchange rate of RMB"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Marxism Research Institute,Chinese Academy of Social Sciences,Beijing,China"
            },
            {
                "name": "CHEN Qiu-gui",
                "org": "Marxism Research Institute,Chinese Academy of Social Sciences,Beijing,China"
            }
        ],
        "venue": "China Business and Market",
        "year": 2010
    },
    "pxzC5478": {
        "id": "pxzC5478",
        "title": "On the Fundamental Problems of the Effect Theory in Economics",
        "abstract": "The author first puts forward the three fundamental problems with theories of effect in Economics. And the more important problem with this theory is that, while the effects are equal to each other, there will not commodity exchange emerge. So, the commodity exchange ratio can not be determined by effect. This shows that behaviors of commodity exchange in the market can not be explained by the theory of effect. And this also can be used to determine or measure value of commodity.",
        "keywords": [
            "utility function",
            "ordinal utility",
            "cardinal utility",
            "commodity exchange",
            "economics"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Chinese Academy of Social Sciences, Beijing, China"
            }
        ],
        "venue": "China Business and Market",
        "year": 2008
    },
    "PekkRzxR": {
        "id": "PekkRzxR",
        "title": "Sraffa's Calculation Error and the Historical Transformation Process of the Value",
        "abstract": "Sraffa tries to obtain the general profitability and(production) price directly from some quantitative relation of the commodity production,and how to treat sraffa's method has been the touchstone to trial scholars' understanding level on Marx's labor theory of value.Through the comprehensive analysis on two numerical method of Sraffa,the article points out the calculation error,denies sraffa's method,and offered the interpretation and solutions from the perspective of the labor theory of value,and showed the value transform history and logic process.",
        "keywords": [
            "labor theory of value",
            "Marx",
            "value transform",
            "Sraffa"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Institute of Marxism,Chinese Academy of Social Sciences,Beijing ,China"
            }
        ],
        "venue": "Journal of Hebei University of Economics and Business",
        "year": 2013
    },
    "n2GWSrxA": {
        "id": "n2GWSrxA",
        "title": "Altered lncRNA expression following sciatic nerve resection in rats",
        "abstract": "Objective: To analyze the expression of lncRNA in the dorsal root ganglia(DRGs) after resection of the sciatic nerve in rats.Methods: The expression of lncRNAs was examined in a sciatic nerve resection model at 0 d、1 d、4 d and 7 d by using an rat lncRNA array.The lncRNA expression was also confirmed by quantitative real-time polymerase chain reaction(qRT-PCR).Gene coexpression network was constructed according to the normalized signal intensity of specific expression lncRNAs and mRNAs.Results: A total of 24 lncRNAs were identified which were significantly down-regulated in the DRGs after resection from 0 through 1 and 4 until 7 d.The expression of lncRNA AF130881 and AB020616 analyzed by qRT-PCR was in agreement with the microarray data.The network was constructed from lncRNA AF130881 and AB020616 positively or negatively coexpressed with 25 coding mRNAs at the serial time points.Conclusion: This study demonstrated a different involvement of lncRNAs in the DRGs after resection of the sciatic nerve in a rat model.",
        "keywords": [
            "Quantitative real-time polymerase chain reaction",
            "sciatic nerve resection",
            "dorsal root ganglia",
            "long noncoding RNA",
            "rats"
        ],
        "authors": [
            {
                "name": "QIAN Tianmei",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "GAO Rong",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "YU Bin",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "DING Fei",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "GU Xiaosong",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            }
        ],
        "venue": "Medical Journal of Communications",
        "year": 2012
    },
    "oR8ogbPQ": {
        "id": "oR8ogbPQ",
        "title": "MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury.",
        "abstract": "MicroRNAs (miRNAs or miRs) are involved in phenotype modulation of neural cells after peripheral nerve injury. The effects of miRNAs on the survival of dorsal root ganglion (DRG) neurons, however, have not yet been well understood. In this study, microarray profiling indicated that 13 miRNAs were differentially expressed in rat DRGs (L4-L6) during the initial 7d period post sciatic nerve transection, and that the expressions of miR-21 and miR-222 (2 out of the 13 miRNAs) were continually increased over the time period. Tissue inhibitor of metalloproteinase 3 (TIMP3), a pro-apoptotic protein in various cancer cells, was identified as a common target of miR-21 and miR-222. Over-expression of miR-21 and miR-222 inhibited cell apoptosis and enhanced cell viability in cultured DRG neurons. IL-6 could induce up-regulation of miR-21 expression. All the results showed that miR-21 and miR-222 inhibited neuronal apoptosis at least partially through suppressing TIMP3 after peripheral nerve injury.",
        "keywords": [
            "apoptosis",
            "dorsal root ganglion neuron",
            "timp3",
            "mir-21",
            "mir-222"
        ],
        "authors": [
            {
                "name": "Songlin Zhou",
                "org": "School of Biology and Basic Medical Sciences, Soochow University, Suzhou, JS 215123, PR China; Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Shibo Zhang",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Yaxian Wang",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Sheng Yi",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Lili Zhao",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Xiaoyan Tang",
                "org": "Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China."
            },
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Xiaosong Gu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            },
            {
                "name": "Fei Ding",
                "org": "School of Biology and Basic Medical Sciences, Soochow University, Suzhou, JS 215123, PR China; Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Co-innovation Center of Neuroregeneration, 19 Qixiu Road, Nantong, JS 226001, PR China."
            }
        ],
        "venue": "Neuroscience letters",
        "year": 2015
    },
    "odkjl0zr": {
        "id": "odkjl0zr",
        "title": "Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury",
        "abstract": "The inhibitory environment that surrounds the lesion site and the lack of intrinsic regenerative capacity of the adult mammalian central nervous system (CNS) impede the regrowth of injured axons and thereby the reestablishment of neural circuits required for functional recovery after spinal cord injuries (SCI). To circumvent these barriers, biomaterial scaffolds are applied to bridge the lesion gaps for the regrowing axons to follow, and, often by combining stem cell transplantation, to enable the local environment in the growth-supportive direction. Manipulations, such as the modulation of PTEN/mTOR pathways, can also enhance intrinsic CNS axon regrowth after injury. Given the complex pathophysiology of SCI, combining biomaterial scaffolds and genetic manipulation may provide synergistic effects and promote maximal axonal regrowth. Future directions will primarily focus on the translatability of these approaches and promote therapeutic avenues toward the functional rehabilitation of patients with SCIs.",
        "keywords": [
            "spinal cord injury",
            " biomaterial",
            " extrinsic barrier",
            " intrinsic regeneration capacity"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Nantong University"
            },
            {
                "name": "Xiaosong Gu",
                "org": "Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, Nantong 226001, Peoples R China; Nantong Univ, Coinnovat Ctr Neuroregenerat, Minist Educ, Nantong 226001, Peoples R China"
            }
        ],
        "venue": "Frontiers of Medicine in China",
        "year": 2018
    },
    "It68kkXX": {
        "id": "It68kkXX",
        "title": "Expression and identification of olfactory receptor in dorsal root ganglia and sciatic nerves",
        "abstract": "Objective: To investigate the presence of expression of olfactory receptors in dorsal root ganglia(DRGs) and sciatic nerves(SNs).Methods: The expression of olfactory receptors in dorsal root ganglia and sciatic nerves was examined at different time points post sciatic nerve transection by using rat microarrays.The microarray data was further confirmed by RT-PCR.Results: There are a large number of the expressed olfactory receptors in dorsal root ganglia and sciatic nerves,and the expressions of olfactory receptors in dorsal root ganglia and proximal sciatic nerves were changed post sciatic nerve transection.Conclusion: we,for the first time,reported the presence of olfactory receptors in dorsal root ganglia and sciatic nerves and regarded these olfactory receptors might play roles in detecting stimulus post sciatic nerve transection.",
        "keywords": [
            "dorsal root ganglion",
            "sciatic nerve",
            "olfactory receptor",
            "nerve transection"
        ],
        "authors": [
            {
                "name": "LI Shiying",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "WANG Yongjun",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "GU Yun",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "GONG Leilei",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "YAO Dengbing",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "DING Fei",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "GU Xiaosong",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            }
        ],
        "venue": "Medical Journal of Communications",
        "year": 2012
    },
    "lISwM1qR": {
        "id": "lISwM1qR",
        "title": "Altered microRNA expression following sciatic nerve resection in the dorsal root ganglia",
        "abstract": "Objective To profile the expression of microRNAs(miRNAs) in the dorsal root ganglia(DRG) after resection of the sciatic nerve for short time in rats.Methods The expression of miRNAs in a sciatic nerve resection model at 0 hour,3 hours and 9 hours were examined by an Agilent rat miRNA array.The miRNA expression was confirmed by real time Taqman PCR.Results 4 and 7 miRNAs were significantly up-regulated in the DRG by > 1.3-fold after 3 and 9 hours of resection,respectively;meanwhile,2 and 5 miRNAs significantly down-regulated.The expression of miR-188 and miR-500 analyzed by real time Taqman PCR was in agreement with the microarray data.Conclusion This study demonstrated a different involvement of miRNAs in the DRG after resection of the sciatic nerve in a rat model.",
        "keywords": [
            "Nerve resection",
            "Dorsal root ganglia",
            "MicroRNA"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ".Key Laboratory of Neuroregeneration,Nantong University,Nantong ,China"
            },
            {
                "name": "ZHOU Song-lin",
                "org": ".Key Laboratory of Neuroregeneration,Nantong University,Nantong ,China"
            },
            {
                "name": "QIAN Tian-mei",
                "org": ".Key Laboratory of Neuroregeneration,Nantong University,Nantong ,China"
            },
            {
                "name": "YAO Deng-bing",
                "org": ".Key Laboratory of Neuroregeneration,Nantong University,Nantong ,China"
            },
            {
                "name": "DING Fei",
                "org": ".Key Laboratory of Neuroregeneration,Nantong University,Nantong ,China"
            },
            {
                "name": "GU Xiao-song",
                "org": ".Key Laboratory of Neuroregeneration,Nantong University,Nantong ,China"
            }
        ],
        "venue": "Anatomy Research",
        "year": 2010
    },
    "CeL2WO08": {
        "id": "CeL2WO08",
        "title": "miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury.",
        "abstract": "The regulation of Schwann cell (SC) responses to injury stimuli by microRNAs (miRNAs) remains to be explored. Here, we identified 17 miRNAs that showed dynamic expression alterations at five early time points following rat sciatic nerve resection. Then we analyzed the expression pattern of 17 miRNAs, and integrated their putative targets with differentially expressed mRNAs. The resulting 222 potential targets were mainly involved in cell phenotype modulation, including immune response, cell death and cell locomotion. Among 17 miRNAs, miR-182 expression was up-regulated. The enhanced expression of miR-182 was correlated with nerve injury-induced phenotype modulation of SCs. Further investigation revealed that fibroblast growth factor 9 (FGF9) and neurotrimin (NTM) were two direct targets of miR-182 in SCs, with miR-182 binding to the 3'-untranslated region of FGF9 and NTM. Silencing of FGF9 and NTM recapitulated the inhibiting effect of miR-182 mimics on SC proliferation and migration, respectively, whereas enforced knockdown of FGF9 and NTM reversed the promoting effect of miR-182 inhibitor on SC proliferation and migration, respectively. Our data indicate that nerve injury inhibits SC proliferation and migration through rapid regulation of miR-182 by targeting FGF9 and NTM, providing novel insights into the roles of miRNAs in nerve injury and repair.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China."
            },
            {
                "name": "Tianmei Qian",
                "org": ""
            },
            {
                "name": "Yongjun Wang",
                "org": ""
            },
            {
                "name": "Songlin Zhou",
                "org": ""
            },
            {
                "name": "Guohui Ding",
                "org": ""
            },
            {
                "name": "Fei Ding",
                "org": ""
            },
            {
                "name": "Xiaosong Gu",
                "org": ""
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2012
    },
    "7dl0n5a0": {
        "id": "7dl0n5a0",
        "title": "Altered long noncoding RNA expressions in dorsal root ganglion after rat sciatic nerve injury.",
        "abstract": "Dorsal root ganglia (DRG) neurons spontaneously undergo robust neurite growth after axotomy. Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. However, the functions of lncRNAs in the regulation of responses of DRG neurons to injury stimuli remain untested. Here, lncRNA microarray analysis was performed to profile the lncRNAs in L4-L6 DRGs following rat sciatic nerve resection. The 105 lncRNAs were identified to be differentially expressed at 0, 1, 4, 7 d post injury. A coexpression network of 24 down-regulated lncRNAs and coding genes was constructed, and 115 targets of these 24 lncRNAs were found to be mainly involved in cell phenotype modulation, including glial cell migration, purinergic nucleotide receptor signaling pathway, vasodilation, regulation of multi-organism process, and neuropeptide signaling pathway, and also to be potentially associated with several key regeneration signaling pathways, including MAPK signaling pathway, and neuroactive ligand-receptor interaction. LncRNA BC089918 was selected from 24 down-regulated lncRNAs for validation by quantitative real-time polymerase chain reaction and in situ hybridization. And silencing of BC089918 with small interfering RNAs indicted that the lncRNA had a particular promoting effect on neurite outgrowth. Our data demonstrated a distinct involvement of lncRNAs in DRGs after nerve injury, thus contributing to illustration of molecular mechanisms responsible for nerve regeneration.",
        "keywords": [
            "long noncoding rna",
            "nerve regeneration"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China."
            },
            {
                "name": "Songlin Zhou",
                "org": ""
            },
            {
                "name": "Wen Hu",
                "org": ""
            },
            {
                "name": "Tianmei Qian",
                "org": ""
            },
            {
                "name": "Rong Gao",
                "org": ""
            },
            {
                "name": "Guohui Ding",
                "org": ""
            },
            {
                "name": "Fei Ding",
                "org": ""
            },
            {
                "name": "Xiaosong Gu",
                "org": ""
            }
        ],
        "venue": "Neuroscience letters",
        "year": 2013
    },
    "NYHscDGn": {
        "id": "NYHscDGn",
        "title": "MiR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury.",
        "abstract": "The regulative effects of microRNAs (miRNAs) on responses of Schwann cells to a nerve injury stimulus are not yet clear. In this study, we noted that the expression of eight miRNAs was downregulated at different time points following rat sciatic nerve transection, and found that 368 potential targets of these eight miRNAs were mainly involved in phenotypic modulation of Schwann cells. Of these miRNAs, miR-9 was identified as an important functional regulator of Schwann cell migration that was a crucial regenerative response of Schwann cells to nerve injury. In vitro, upregulated expression of miR-9 inhibited Schwann cell migration, whereas silencing of miR-9 promoted Schwann cell migration. Intriguingly, miR-9 exerted this regulative function by directly targeting collagen triple helix repeat containing protein 1 (CTHRC1), which in turn inactivated downstream Rac1 GTPase. Rac1 inhibitor reduced the promotive effects of anti-miR-9 on Schwann cell migration. In vivo, high expression of miR-9 reduced Schwann cell migration within a regenerative nerve microenvironment. Collectively, our results confirmed the role of miR-9 in regulating Schwann cell migration after nerve injury, thus offering a new approach to peripheral nerve repair.",
        "keywords": [
            "CTHRC1",
            "Migration",
            "Peripheral nerve regeneration",
            "Schwann cell",
            "miR-9"
        ],
        "authors": [
            {
                "name": "Songlin Zhou",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China."
            },
            {
                "name": "Rong Gao",
                "org": ""
            },
            {
                "name": "Wen Hu",
                "org": ""
            },
            {
                "name": "Tianmei Qian",
                "org": ""
            },
            {
                "name": "Na Wang",
                "org": ""
            },
            {
                "name": "Guohui Ding",
                "org": ""
            },
            {
                "name": "Fei Ding",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Xiaosong Gu",
                "org": ""
            }
        ],
        "venue": "Journal of cell science",
        "year": 2014
    },
    "gPDKQWcF": {
        "id": "gPDKQWcF",
        "title": "Altered microRNA expression following sciatic nerve resection for 1 week",
        "abstract": "Objective: To profile the expression of microRNAs(miRNAs) in the dorsal root ganglia(DRG) after resection of the sciatic nerve for 1 week in rats.Methods: We examined the expression of miRNAs in a sciatic nerve resection model at 0 day and 7 days using an Agilent rat miRNA array.The miRNA expression was confirmed by Real time Taqman PCR.Results: 13 and 5 miRNAs were significantly up-regulated by 1.4-fold and down-regulated by 1% in the DRG after 1 week of resection,respectively.The expression of the selected miRNAs analyzed by Real time Taqman PCR was in agreement with the microarray data(up-regulated: miR-21,miR-221;down-regulated: miR-500,miR-551b).Conclusion: This study demonstrated a different involvement of miRNAs in the DRG after resection of the sciatic nerve in a rat model.",
        "keywords": [
            "dorsal root ganglia",
            "nerve resection",
            "microRNA"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Nantong "
            },
            {
                "name": "ZHOU Songlin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Nantong "
            },
            {
                "name": "QIAN Tianmei",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Nantong "
            },
            {
                "name": "WANG Yongjun",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Nantong "
            },
            {
                "name": "DING Fei",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Nantong "
            },
            {
                "name": "GU Xiaosong",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Nantong "
            }
        ],
        "venue": "Journal of Nantong University(Medical Sciences)",
        "year": 2010
    },
    "UPwLVnZh": {
        "id": "UPwLVnZh",
        "title": "Analysis of molecular regulation in nerve tissues at early stages following sciatic nerve transection",
        "abstract": "Objective:To investigate the molecular mechanism of signal regulation in the proximal nerve after resection of the sciatic nerve by using gene microarray combined with Signal-Flow analysis.Methods:The proximal nerve tissues of 0.5cm were collected after the sciatic nerves of SD rats were transected at 0h,0.5h,1h,3h,6h and 9h,respectively.The dynamic gene regulatory network was inferred from time-series measurements of microarray data followed by screen of differential gene and pathway analysis.The mRNA expression was also further confirmed by qRT-PCR.Results:A total of 2850 differential genes were identified.Both anti-apoptosis factors and tight junction factors were the key elements in the gene regulatory network.Birc2,Birc3 and Tnfrsf1a were upregulated at the early stage,and inhibited the expression of apoptosis-related genes,whereas tight junction protein,cldn14,promoted the binding with other family members.Conclusion:Both anti-apoptosis factors and tight junction factors might be the early regulatory molecules involved in the nerve tissue regeneration,suggesting an association with the regulation of intrinsic growth capacity after nerve tissue injury.",
        "keywords": [
            "tight junction protein",
            "reverse transcript polymerase chain reaction",
            "gene regulatory network",
            "schwann cell",
            "proximal nerve",
            "anti-apoptosis",
            "SD rats",
            "nerve resection"
        ],
        "authors": [
            {
                "name": "WANG Yongjun",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "TANG Xin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "GU Yun",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "LI Shiying",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "YAO Dengbing",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "DING Fei",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "GU Xiaosong",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            }
        ],
        "venue": "Medical Journal of Communications",
        "year": 2010
    },
    "qcZPh0Sh": {
        "id": "qcZPh0Sh",
        "title": "Analysis of the expression and function of TNC in the proximal stump nerve following sciatic nerve transection",
        "abstract": "Objective: To investigate the expression and function of TNC(tenascin-C) in the proximal nerve stump following sciatic nerve transection.Methods:The expression level and localization of TNC in the proximal nerve stump were examined by frozen section and immunofluorescent staining on 0d and 4d after sciatic nerve transection,and the function of TNC was examined by fibroblasts/Schwann cells co-culture and cell scratch wound assay.Results:The expression of TNC in the proximal nerve stump up-regulated on 4d after sciatic nerve transection and co-localized with Vimentin in epineurium;TNC could promote migration of Schwann cells in vitro co-culture assay.Conclusion:This study shows that TNC secreted by fibroblasts up-regulated after sciatic nerve transection and TNC could promote migration of Schwann cells in vitro.",
        "keywords": [
            "migration",
            "extracellular matrix",
            "immunofluorescent staining",
            "fibroblasts",
            "Schwann cells",
            "reverse transcriptate polymerase chain reaction",
            "rat",
            "co-culture",
            "proximal nerve stump",
            "tenascin-C"
        ],
        "authors": [
            {
                "name": "ZHANG Zhanhu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "WANG Yongjun",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "YU Bin",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "DING Fei",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            },
            {
                "name": "GU Xiaosong",
                "org": "Jiangsu Key Laboratory of Neuroregeneration,Nantong University,Jiangsu "
            }
        ],
        "venue": "Medical Journal of Communications",
        "year": 2012
    },
    "voFk6gCR": {
        "id": "voFk6gCR",
        "title": "Let-7 microRNAs regenerate peripheral nerve regeneration by targeting nerve growth factor.",
        "abstract": "Peripheral nerve injury is a common clinical problem. Nerve growth factor (NGF) promotes peripheral nerve regeneration, but its clinical applications are limited by several constraints. In this study, we found that the time-dependent expression profiles of eight let-7 family members in the injured nerve after sciatic nerve injury were roughly similar to each other. Let-7 microRNAs (miRNAs) significantly reduced cell proliferation and migration of primary Schwann cells (SCs) by directly targeting NGF and suppressing its protein translation. Following sciatic nerve injury, the temporal change in let-7 miRNA expression was negatively correlated with that in NGF expression. Inhibition of let-7 miRNAs increased NGF secretion by primary cultured SCs and enhanced axonal outgrowth from a coculture of primary SCs and dorsal root gangalion neurons. In vivo tests indicated that let-7 inhibition promoted SCs migration and axon outgrowth within a regenerative microenvironment. In addition, the inhibitory effect of let-7 miRNAs on SCs apoptosis might serve as an early stress response to nerve injury, but this effect seemed to be not mediated through a NGF-dependent pathway. Collectively, our results provide a new insight into let-7 miRNA regulation of peripheral nerve regeneration and suggest a potential therapy for repair of peripheral nerve injury.",
        "keywords": [
            "mt",
            " INSERT KEY WORDS HERE",
            " pharmacology"
        ],
        "authors": [
            {
                "name": "Shiying Li",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Xinghui Wang",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Yun Gu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Chu Chen",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Yaxian Wang",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Jie Liu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Wen Hu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Yongjun Wang",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Fei Ding",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Yan Liu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            },
            {
                "name": "Xiaosong Gu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China."
            }
        ],
        "venue": "Molecular therapy : the journal of the American Society of Gene Therapy",
        "year": 2015
    },
    "DloBEE1U": {
        "id": "DloBEE1U",
        "title": "Identification and functional annotation of novel microRNAs in the proximal sciatic nerve after sciatic nerve transection.",
        "abstract": "The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration.",
        "keywords": [
            "proximal sciatic nerve",
            "solexa",
            "microrna",
            "rat"
        ],
        "authors": [
            {
                "name": "Shiying Li",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 210063, China."
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Yongjun Wang",
                "org": ""
            },
            {
                "name": "Dengbing Yao",
                "org": ""
            },
            {
                "name": "Zhanhu Zhang",
                "org": ""
            },
            {
                "name": "Xiaosong Gu",
                "org": ""
            }
        ],
        "venue": "Science China. Life sciences",
        "year": 2011
    },
    "kPDFURXo": {
        "id": "kPDFURXo",
        "title": "miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury.",
        "abstract": "microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. Their roles in regulating the responses of Schwann cells (SCs) to injury stimuli remain unexplored. Here we report dynamic alteration of miRNA expression following rat sciatic nerve injury using microarray analysis. We harvested the proximal nerve stumps and identified 77 miRNAs that showed significant changes at four time points after nerve transection. Subsequently, we analyzed the expression pattern of miRNA, selected one significant profile, and then integrated putative miRNA targets with differentially expressed mRNA yielding 274 potential targets. The 274 targets were mainly involved in cell proliferation, cell locomotion and cellular homeostasis that were known to play important roles in modulating cell phenotype. The upregulation of the miR-221 and miR-222 cluster (miR-221/222) was found to correlate with the injury-induced SC phenotypic modulation. Enhanced expression of miR-221/222 could promote SC proliferation and migration in vitro, whereas silencing their expression resulted in a reduced proliferation and migration. Further studies revealed that longevity assurance homologue 2 (LASS2) was a direct target of miR-221/222 in SCs because miR-221/222 bound directly to the 3'-untranslated region of LASS2, thus reducing both mRNA and protein levels of LASS2. Silencing of LASS2 recapitulated the effects of miR-221/222 mimics, whereas enforced knockdown of LASS2 reversed the suppressive effects of miR-221/222 inhibitors. Our findings indicate that injury promotes SC proliferation and migration through the regulation of miR-221/222 by targeting LASS2, and provide new insights into the role of miRNAs in nerve regeneration.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China."
            },
            {
                "name": "Songlin Zhou",
                "org": ""
            },
            {
                "name": "Yongjun Wang",
                "org": ""
            },
            {
                "name": "Tianmei Qian",
                "org": ""
            },
            {
                "name": "Guohui Ding",
                "org": ""
            },
            {
                "name": "Fei Ding",
                "org": ""
            },
            {
                "name": "Xiaosong Gu",
                "org": ""
            }
        ],
        "venue": "Journal of cell science",
        "year": 2012
    },
    "s0iZF5gT": {
        "id": "s0iZF5gT",
        "title": "Altered microRNA expression following sciatic nerve resection in rats",
        "abstract": "Objective: To profile the expression of microRNAs(miRNAs) in the proximal nerve after resection of the sciatic nerve for 3 and 6 hours in rats.Methods: The expression of miRNAs in a sciatic nerve resection model was examined at 0 hour,3 hours and 6 hours by using an Agilent rat miRNA array.The miRNA expression was confirmed by real time Taqman PCR.Results: 4 and 11 miRNAs were significantly up-regulated in the proximal nerve by >1.5-fold after 3 and 6 hours of resection,respectively;meanwhile,3 and 6 miRNAs significantly down-regulated.The expression of miR-132 and miR-223 analyzed by real time Taqman PCR was in agreement with the microarray data.Conclusion: This study demonstrated a different involvement of miRNAs in the proximal nerve after resection of the sciatic nerve in a rat model.",
        "keywords": [
            "sciatic nerve",
            "microRNA",
            "nerve resection",
            "polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "WANG Yongjun",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "ZHOU Songlin",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "YAO Dengbing",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "GU Xiaosong",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            },
            {
                "name": "DING Fei",
                "org": "Key Laboratory of Neuroregeneration,Nantong University,Jiangsu"
            }
        ],
        "venue": "Medical Journal of Communications",
        "year": 2010
    },
    "gPexyMIL": {
        "id": "gPexyMIL",
        "title": "Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model.",
        "abstract": "Our findings suggest that aucubin has a protective effect on articular cartilage and slowing progression of OA in a mouse model. This protective effect may result from inhibiting chondrocyte apoptosis and excessive ROS production.",
        "keywords": [
            "IL-1β",
            "ROS",
            "apoptosis",
            "aucubin",
            "osteoarthritis"
        ],
        "authors": [
            {
                "name": "Bo-Wei Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China."
            },
            {
                "name": "Yi Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China."
            },
            {
                "name": "Zi-Long Yao",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China."
            },
            {
                "name": "Pei-Sheng Chen",
                "org": "Department of Orthopaedics, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, Fujian 350007, People's Republic of China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China."
            },
            {
                "name": "Sheng-Nan Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China."
            }
        ],
        "venue": "Drug design, development and therapy",
        "year": 2019
    },
    "Q80Hws2M": {
        "id": "Q80Hws2M",
        "title": "An evaluations on different therapeutic methods on 478 cases with carpal tunnel syndrome",
        "abstract": "Objective To investigate the best therapeutic methods for carpal tunnel syndrome by analyzing 478 cases. Methods Data of 478 carpal tunnel syndrome cases treated from May 2000 to September 2009 in our hospital was used for retrospective analysis. The data of electroneurophysiological and clinical representations of all the cases were analyzed before and after therapy. Results Obvious differences were found in four different therapeutic methods. For slight CTS, expectant treatment got just the similar result as surgery operation. For serious CTS, surgery operation could cure more patients, However, neither expectant treatment nor surgery operation could treat CTS completely. Conclusion Early diagnosis and therapy is important for carpal tunnel syndrome therapy, different therapeutic methods to be used depend on different extents of CTS injury.",
        "keywords": [
            "Therapeutic method",
            "Median nerve damage",
            "Carpal tunnel syndrome"
        ],
        "authors": [
            {
                "name": "WU Jia-yi",
                "org": ". Department of orthopedics & trauma, NanFang Hospital, Southen Medical University, Guang Zhou , China"
            },
            {
                "name": "HU Jing",
                "org": ". Department of orthopedics & trauma, NanFang Hospital, Southen Medical University, Guang Zhou , China"
            },
            {
                "name": "YU Bin",
                "org": ". Department of orthopedics & trauma, NanFang Hospital, Southen Medical University, Guang Zhou , China"
            },
            {
                "name": "WANG Gang",
                "org": ". Department of orthopedics & trauma, NanFang Hospital, Southen Medical University, Guang Zhou , China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2010
    },
    "hlQFkCPi": {
        "id": "hlQFkCPi",
        "title": "Finite element analysis of abruption of lower tibiofibular ligament union with single screw fixation",
        "abstract": "[Objective] To explore the biomechanical characteristics of different ways of single screw internal fixation for abruption of lower tibiofibular ligament union through finite element(FE)analysis and therefore to provide scientific foundation for clinic application.[Method]Three-dimensional FE models of the different ways of single screw internal fixation for abruption of lower tibiofibular ligament union were established by helical CT scan data of normal adult human ankles.The static weight-bearing state of human body in neutral position with one foot standing were simulated to compare the differences between different ways of internal fixation in screw von Mises stress distribution,the displacement of the tibia and fibula.[Result]A total of twelve types of abruption of lower tibiofibular ligament union FE models including bones,ligaments and screw were constructed.FE simulation showed significant differences between the different ways of fixation with regard to the biomechanical characteristics in the model.A 4.5 mm screw to be fixed through four layers of cortical bone at 2 cm away from the horizontal plane of the ankle showed minimum von Mises stress and displacement of the tibia and fibula.[Conclusion]A better fixation stability may be achieved by using 4.5 mm screw through four layers of cortical bone at 2 cm away from the horizontal plane of the ankle for abruption of lower tibiofibular ligament union.",
        "keywords": [
            "finite element analysis",
            "biomechanics",
            "internal fixation",
            "abruption of lower tibiofibular ligament union"
        ],
        "authors": [
            {
                "name": "DAI Hai-fei",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "ZHANG Kai-rui",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2012
    },
    "4Vwpt0rx": {
        "id": "4Vwpt0rx",
        "title": "Open reduction and internal fixation versus closed reduction and external fixation in distal radius fractures: a systematic review",
        "abstract": "[Objective]To determine the effect of open reduction and internal fixation(ORIF) versus closed reduction and external fixation(CREF) in the fractures of the distal radius. [Methods]The Cochrane library,MEDLINE(1966~2009),EMBASE(1966~2009),CBM(1979~2009) and the relevant English and Chinese orthopedic journals were searched for the randomized controlled trials and controlled clinical trials of open reduction and internal fixation versus closed reduction and external fixation in the fractures of the distal radius.The systematic review was performed using the method recommended by the Cochrane Collaboration.[Results]Six controlled trials including 4 randomized controlled trials were involved,revolving 380 patients.The results of Meta-analysis showed the rate of total complications and pin track infections in ORIF group was significantly lower than that in CREF group,respectively [RR =0.37,95% CI(0.15,0.88),P=0.03 and RR= 0.13,95%CI(0.03,0.46),P=0.002].Supination,pronation or DASH score in ORIF group was superior to that in CREF group,respectively [WMD =8.85,95%CI(6.24,11.45) and WMD=-8.67,95%CI(-12.88,-4.46)].There were no significant differences in the malunion rate and grip strength.[Conclusion]Taking into account the complication rate and function recovery,open reduction and internal fixation is a better alternative to closed reduction and external fixation for distal radius fractures.However,more high quality,large-scale randomized clinical trials are required for more accurate conclusions.",
        "keywords": [
            "closed reduction and external fixation",
            "open reduction and internal fixation",
            "systematic review",
            "fracture of the distal radius",
            "orthopaedics",
            "clinical trials"
        ],
        "authors": [
            {
                "name": "CUI Zhuang",
                "org": ",et al.Department of Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LENG Xiao-qing",
                "org": ",et al.Department of Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2010
    },
    "x79iQkj2": {
        "id": "x79iQkj2",
        "title": "Contact characteristics of articular surfaces for talus during gait-a finite element analysis",
        "abstract": "[Objective]To construct a three-dimensional finite element model(FEM) of normal adult human ankle in order to supply a digital platform for biomechanical research of talar cartilage stress during gait,and understand the stress distribution of cartilage biomechanical characteristics. [Methods]A three-dimensional FEM of normal adult human ankle was established through helical CT images and meshed,for analysis of contact pressure and Von Mises stress distribution of cartilage during gait.[Results]An ankle model was constructed including bones,cartilage,ligaments,which was composed of 21 865 nodes,73 440 elements.The articular surface contact stress and the Von Mises stress distribution and stress values were different in different stance phases.[Conclusion]The application of FEM is valid and reasonable.It could be optimized by the interference of anatomical data and biomechanical experiments and used in further articular cartilage biomechanics research.",
        "keywords": [
            "finite element analysis",
            "talus",
            "biomechanics",
            "articular cartilage"
        ],
        "authors": [
            {
                "name": "LU Chang-huai",
                "org": ",et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "CHEN Hui-qiang",
                "org": ",et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2011
    },
    "11sZ33zf": {
        "id": "11sZ33zf",
        "title": "Efficacy of early U-brace treatment for ankle lateral collateral ligament injury",
        "abstract": "Objective To observe early efficacy of U-brace treatment for ankle lateral collateral ligament injury. Methods 134 patients that were Ⅰ or Ⅱ degree of injury were randomly divided into two groups. Observation group were treated with DARCO ankle brace or U-fixed, while control group were treated with U-plaster or plaster fixed. Results In observation group, the cure rate was 73.0%, and total efficiency was 95.2%; in control group the cure rate was 56.3%, and total efficiency was 83.1%. The average recovery time of the observation group was (16.5±6.6) days, while the control group was (22.3±8.3) days. Satisfaction rate of the observation group was 92.1%, and it was 69.0% in the control group. All these data of the two groups had statistically significant differences. Conclusions DARCO U-ankle brace treatment of ankle ligament injury is better than plaster.",
        "keywords": [
            "surgical",
            "Casts",
            "Braces",
            "External fixators",
            "Collateral ligaments"
        ],
        "authors": [
            {
                "name": "DOU Yong-gang",
                "org": ". The Department of Orthopedic Trauma, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "LI Jian-wei",
                "org": ". The Department of Orthopedic Trauma, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "YU Bin",
                "org": ". The Department of Orthopedic Trauma, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Joint Surgery(Electronic Edition)",
        "year": 2012
    },
    "ekGvZk2i": {
        "id": "ekGvZk2i",
        "title": "Ultrastructural changes of the skeletal muscle cells of rats subjected to exhausting exercises and the protective effect of vitamin E]",
        "abstract": "To investigate the ultrastructural changes of the mitochondria in the skeletal muscle cells of rats subjected to repeated exhausting exercises on treadmill and the protective effect of oral vitamin E.Thirty male SD rats were randomized into control group (n=10), exhausting exercise group (n=10) and exhausting exercise group with oral vitamin E treatment (n=10), with the latter two groups taking repeated exhausting running exercises on the treadmill in a course of 4 weeks. At the end of the course of exercises, the rats were sacrificed and the quadriceps femoris muscles isolated for observation the ultrastructures of the skeletal muscle cells by transmission electron microscope (TEM).After 4-week exhausting exercises, the myofilaments of the skeletal muscle were seen in disordered alignment, and the mitochondria exhibited abnormal morphological changes of swelling and vacuolar degeneration. In vitamin E-treated rats also undertaking the exercise, the ultrastructures of the skeletal muscle cells were almost normal as compared with the normal control group.Vitamin E can protect the function of the skeletal muscle mitochondria of rats taking repeated exhausting exercises.",
        "keywords": [],
        "authors": [
            {
                "name": "Ji-wei Luo",
                "org": "Department of Othopeadic and Traumatology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China."
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Cheng-he Qin",
                "org": ""
            },
            {
                "name": "Jian-cheng Yang",
                "org": ""
            },
            {
                "name": "Wen-tao Lin",
                "org": ""
            },
            {
                "name": "Xi-yuan Wen",
                "org": ""
            },
            {
                "name": "Li-ying Huang",
                "org": ""
            }
        ],
        "venue": "Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA",
        "year": 2003
    },
    "qI8Lryxh": {
        "id": "qI8Lryxh",
        "title": "Operative versus nonoperative treatment for acute Achilles tendon rupture: a meta-analysis based on current evidence.",
        "abstract": "The aim of this study was to evaluate, in a meta-analysis, the clinical effectiveness of operative treatment for acute Achilles tendon rupture (AATR) compared with nonoperative treatment.We systematically searched six electronic databases (Medline, Embase, Clinical Ovid, BIOSIS and Cochrane registry of controlled clinical trials) to identify randomised controlled trials (RCTs) in which operative treatment was compared with nonoperative treatment for AATR from 1980 to 2011. Trial quality was assessed using the modified Jadad scale. The data was using fixed-effects and random-effects models with mean differences and risk ratios for continuous and dichotomous variables, respectively.Ten RCTs with a total of 894 patients were screened. The results showed that operative was superior to nonoperative treatment regarding lower risk of re-rupture (P = 0.002) and shorter time for sick leave (P = 0.009) but inferior to nonoperative treatment regarding complication risks (P = 0.004). No significant difference was identified between the two methods regarding the number of patients who successfully returned to pre-injury sports (P = 0.30). Subgroup analyses revealed significant differences in relation to scar adhesion (P < 0.00001), superficial infection (P = 0.05), and sensibility disturbance (P = 0.0003). However, no significant differences were found between the two interventions in relation to deep infection (P = 0.22), deep vein thrombosis (DVT) (P = 0.14), and extreme Achilles tendon lengthening (P = 0.31). Little consensus was obtained in the functional recovery from current trials as a result of an inconsistent assessment system.Compared with conservative treatment, operative treatment can effectively reduce the risk of re-rupture but increase the probability of complications. The increased complication risk may be associated with open repair surgery. However, no sufficient evidence is available from current studies to support the belief that operation may lead to better functional recovery.",
        "keywords": [
            "Sick Leave",
            " Nonoperative Treatment",
            " Deep Infection",
            " Sensibility Disturbance",
            " Superficial Infection"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China."
            },
            {
                "name": "Bowei Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Anfu Chen",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Fu Dong",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            }
        ],
        "venue": "International orthopaedics",
        "year": 2012
    },
    "hToMtxlQ": {
        "id": "hToMtxlQ",
        "title": "Exercises at different intensities and sequential changes of rat skeletal muscle cell apoptosis]",
        "abstract": "To study the effect of exercises of different intensities on rat skeletal muscle cell apoptosis.Rat models of exhaustive exercise-induced skeletal muscle injury was established using tread mill exercises at different speeds, and the skeletal muscle cell apoptosis was detected using propidium iodide (PI) staining and flow cytometry.No obvious gastrocnemius cell apoptosis was observed in rats with normal exercise (P>0.05), but the cell apoptosis index was statistically significant in moderate and exhaustive exercise groups (P<0.05), reaching the highest level in exhaustive exercise group after exercising. The gastrocnemius cell apoptosis index increased obviously on days 1 and 3 of exercise, and stabilized in moderate and exhaustive exercise groups.Exercises can evoke cell apoptosis and accelerate apoptotic cell clearance, and the imbalance between the two events during exercises may contribute to skeletal muscle injury.",
        "keywords": [
            "tread train",
            "apoptosis",
            "flow cytometry",
            "skeletal muscle"
        ],
        "authors": [
            {
                "name": "Bao-ta Cai",
                "org": "Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Jiang-ping Zhao",
                "org": "Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Xing Zhang",
                "org": "Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2006
    },
    "rrJeCajq": {
        "id": "rrJeCajq",
        "title": "Establishment and motion simulation of postoperative digital model with Scandinavian Total Ankle Replacement",
        "abstract": "Objective To investigate simulating motions of postoperative digital model with Scandinavian Total Ankle Replacement(STAR).Methods 3D postoperative digital model with STAR was established through the software of Mimics 10.01,Geomgic studio 10.0 and PRO/E 2.0,and then its motions were simulated through the software of PRO/E 4.0.Results Motion simulation videos of postoperative digital model with STAR were successfully established,including plantar flexion,dorsal flexion,adduction,abduction,inversion and eversion.All motions were iconically presented,while,postoperative theoretical range of all motions were obtained.Conclusions Motion simulation of postoperative digital model with STAR is beneficial to prevent operative failure and improve the operative accuracy by preoperatively presumption of the postoperative theoretical range of motion(ROM) of joint prosthesis.",
        "keywords": [
            "Scandinavian total ankle replacement(STAR)",
            "Total ankle replacement",
            "Digital Model",
            "Motion simulation"
        ],
        "authors": [
            {
                "name": "XU Hong-zhang",
                "org": " Department of Orthopaedic Traumatic,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": " Department of Orthopaedic Traumatic,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Anatomy",
        "year": 2011
    },
    "uL6JZjU9": {
        "id": "uL6JZjU9",
        "title": "ELP2 negatively regulates osteoblastic differentiation impaired by tumor necrosis factor α in MC3T3-E1 cells through STAT3 activation.",
        "abstract": "Tumor necrosis factor-α (TNF-α) is a pluripotent signaling molecule. The biological effect of TNF-α includes slowing down osteogenic differentiation, which can lead to bone dysplasia in long-term inflammatory microenvironments. Signal transducer and activator of transcription 3 (STAT3)-interacting protein 1 (StIP1, also known as elongator complex protein 2, ELP2) play a role in inhibiting TNF-α-induced osteoblast differentiation. In the present study, we investigated whether and how ELP2 activation mediates the effects of TNF-α on osteoblastic differentiation. Using in vitro cell cultures of preosteoblastic MC3T3-E1 cells, we found that TNF-α inhibited osteoblastic differentiation accompanied by an increase in ELP2 expression and STAT3 activation. Forced ELP2 expression inhibited osteogenic differentiation of MC3T3-E1 cells, with a decrease in the expression of osteoblast marker genes, alkaline phosphatase activity, and matrix mineralization capacity. In contrast, ELP2 silencing ameliorated osteogenic differentiation in MC3T3-E1 cells, even after TNF-α stimulation. The TNF-α-induced inhibitory effect on osteoblastic differentiation was therefore mediated by ELP2, which was associated with Janus kinase 2 (JAK2)/STAT3 activation. These results suggest that ELP2 is upregulated at the differentiation of MC3T3-E1 cells into osteoblasts and inhibits osteogenic differentiation in response to TNF-α through STAT3 activation.",
        "keywords": [
            "ELP2",
            "osteoblastic differentiation",
            "signal transducer and activator of transcription 3",
            "tumor necrosis factor-α"
        ],
        "authors": [
            {
                "name": "Chang-Peng Xu",
                "org": "Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Hong-Tao Sun",
                "org": "Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Ya-Jun Yang",
                "org": "Department of Pharmacology, Guangdong Medical University, Zhanjiang, Guangdong, People's Republic of China."
            },
            {
                "name": "Zhuang Cui",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Jian Wang",
                "org": "Department of Orthopaedics, The Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, People's Republic of China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Fa-Zheng Wang",
                "org": "Department of Orthopaedics, The First People's Hospital of Kashgar Prefecture, Kashgar, Xinjiang, People's Republic of China."
            },
            {
                "name": "Qing-Po Yang",
                "org": "Department of Orthopaedics, The First People's Hospital of Kashgar Prefecture, Kashgar, Xinjiang, People's Republic of China."
            },
            {
                "name": "Yong Qi",
                "org": "Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, People's Republic of China."
            }
        ],
        "venue": "Journal of cellular physiology",
        "year": 2019
    },
    "GeNaXJ6L": {
        "id": "GeNaXJ6L",
        "title": "Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats.",
        "abstract": "Osteoarthritis (OA) is a most commonly multifactorial degenerative joint disease along with the aging population, particularly in postmenopausal women. During the onset of OA, articular cartilage and subchondral bone act in concert as a functional unit. This present study is to investigate the effects of early or late treatment with recombinant lubricin on the onset of osteoarthritis (OA) in ovariectomized (OVX) rats. We found that both early and late recombinant lubricin treatments attenuated the onset of OA by positive feedback loop between articular cartilage and subchondral bone, although late treatment contributed to a lesser effect compared with early treatment. Specifically, treatment with recombinant lubricin protected articular cartilage from degeneration, demonstrated by lower proteoglycan loss, lower OARSI scores, less calcification cartilage zone and reduced immunostaining for collagen X (Col X) and matrix metalloproteinase (MMP-13) but increased the expression of lubricin, in comparison with vehicle-treated OVX rat group. Further, chondroprotective effects of lubricin normalized bone remodeling in subchondral bone underneath. It's suggested that treatment with recombinant lubricin inhibited the elevation of TRAP and Osterix positive cells in OVX rats and led to the normalization of subchondral bone microarchitectures with the suppression of subsidence of bone volume ratio (BV/TV) and trabecular thickness (Tb.Th) and the increase of trabecular separation (Tb.Sp) in vehicle-treated OVX rats. What's more, the normalization of subchondral bone in turn attenuated the articular cartilage erosion by inhibiting vascular invasion from subchondral bone to calcified cartilage zone, exemplified by inhibiting the elevation of CD31 positive cells in calcified cartilage and angiography in subchondral bone. Together, these results shed light that both early and late recombinant lubricin treatments attenuate the onset of OA by balancing the interplay between articular cartilage and subchondral bone in OVX rats, while also providing a further rationale for its therapeutic targeting to postmenopausal OA and suggesting that treatment timing is a pivotal factor for better effect acquisition.",
        "keywords": [
            "cartilage",
            "lubricin",
            "osteoarthritis",
            "osteoporosis",
            "ovariectomy",
            "subchondral bone"
        ],
        "authors": [
            {
                "name": "Zhuang Cui",
                "org": "Orthopedics and Traumatology, NanFang hospital, Southern Medical University, No. 1838 Guangzhou Da Dao Bei, Guangzhou, Guangdong Province 510515, China."
            },
            {
                "name": "Changpeng Xu",
                "org": "Orthopedics and Traumatology, NanFang hospital, Southern Medical University, No. 1838 Guangzhou Da Dao Bei, Guangzhou, Guangdong Province 510515, China."
            },
            {
                "name": "Xue Li",
                "org": "Orthopedics and Traumatology, NanFang hospital, Southern Medical University, No. 1838 Guangzhou Da Dao Bei, Guangzhou, Guangdong Province 510515, China."
            },
            {
                "name": "Jinqi Song",
                "org": "Orthopedics and Traumatology, NanFang hospital, Southern Medical University, No. 1838 Guangzhou Da Dao Bei, Guangzhou, Guangdong Province 510515, China."
            },
            {
                "name": "Bin Yu",
                "org": "Orthopedics and Traumatology, NanFang hospital, Southern Medical University, No. 1838 Guangzhou Da Dao Bei, Guangzhou, Guangdong Province 510515, China."
            }
        ],
        "venue": "Bone",
        "year": 2015
    },
    "sYsOlSVD": {
        "id": "sYsOlSVD",
        "title": "G-CSF partially mediates bone loss induced by Staphylococcus aureus infection in mice.",
        "abstract": "Bone loss in  (  ) osteomyelitis poses a serious challenge to orthopaedic treatment. This study aimed to elucidate how  infection in bone might induce bone loss. The C57BL/6 mice were injected with  (10 CFU/ml, 100 μl) or with the same amount of vehicle (control) via the tail vein. MicroCT analysis showed bone loss progressing from week 1 to week 5 after infection, accompanied by a decreased number of osteocalcin-positive stained osteoblasts and the suppressed mRNA expression of Runx2 and osteocalcin. Transcriptome profiles of GSE30119 were downloaded and analyzed to determine the differences in expression of inflammatory factors between patients with  infected osteomyelitis and healthy controls, the data showed significantly higher mRNA expression of granulocyte colony-stimulating factor (G-CSF) in the whole blood from patients with  infection. ELISA analysis confirmed an increased level of G-CSF in the bone marrow and serum from  infected mice, which might have been due to the increased amount of F4/80 macrophages. Interestingly, G-CSF neutralizing antibody treatment significantly rescued the bone loss after  infection, as evidenced by its roles in improving BV/TV and preserving osteocalcin- and osterix-positive stained cells. Importantly, we found that G-CSF level was significantly up-regulated in the serum from osteomyelitis patients infected by  Together,  infection might suppress the function of osteoblastic cells and induce progressive bone loss by up-regulating the level G-CSF, suggesting a therapeutic potential for G-CSF neutralization in combating bone loss in  osteomyelitis.",
        "keywords": [
            "Granulocyte colony-stimulating factor",
            "Staphylococcus aureus",
            "bone loss",
            "inflammation"
        ],
        "authors": [
            {
                "name": "Yilong Hou",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Hanjun Qin",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Nan Jiang",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Guanqiao Liu",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Hangtian Wu",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Lang Bai",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Bin Yu",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China."
            },
            {
                "name": "Xianrong Zhang",
                "org": "Nanfang Hospital, Southern Medical University, No.1838 North of Guangzhou Avenue, Guangzhou, 510515, China xianrongzh@smu.edu.cn."
            }
        ],
        "venue": "Clinical science (London, England : 1979)",
        "year": 2019
    },
    "cm9H7T7s": {
        "id": "cm9H7T7s",
        "title": "Cerium-containing α-calcium sulfate hemihydrate bone substitute promotes osteogenesis.",
        "abstract": "Bone substitute offers a promising strategy for the reconstruction of large bone defects. It may be feasible to develop a better substitute material by enhancing the osteoinductivity and delaying the degradation of α-calcium sulfate hemihydrate. In this study, nano cerium oxide was incorporated with α-calcium sulfate hemihydrate at weight ratios of 5 and 10% to form nano cerium oxide-containing α-calcium sulfate hemihydrate. Extracts from α-calcium sulfate hemihydrate, 5 and 10% nano cerium oxide-containing α-calcium sulfate hemihydrate were prepared for in vitro treatment of cells. After critical bone defects were made on the left tibia of male Sprague-Dawley rats, the animals were randomly divided into four groups subjected to the filling with nothing (blank), α-calcium sulfate hemihydrate (control), 5 and 10% nano cerium oxide-containing α-calcium sulfate hemihydrate. Extraction from 5% nano cerium oxide-containing α-calcium sulfate hemihydrate composite stimulated cells proliferation and increased cell migration and mRNA expression of osteoblastic marker genes in primary bone marrow stromal cells. X-ray and micro-computed tomography analyses showed increased bone formation and reduced degradation, and histological analysis showed mineralized staining on the boundary area between composites and bone marrow in the nano cerium oxide-containing α-calcium sulfate hemihydrate group. Immunostaining of osteocalcin confirmed the increased bone formation in the nano cerium oxide-containing α-calcium sulfate hemihydrate group. Nano cerium oxide-containing α-calcium sulfate hemihydrate composite with 5% w/w nano cerium oxide showed a better capacity of enhancing osteogenesis and bone regeneration model than 10% cerium oxide-containing α-calcium sulfate hemihydrate composite. The findings suggested that the nano cerium oxide-containing α-calcium sulfate hemihydrate might be a potential material for bone substitutes since it may promote local bone regeneration.",
        "keywords": [
            "Cerium",
            "bone marrow stromal cells",
            "bone regeneration",
            "bone substitute",
            "calcium sulfate"
        ],
        "authors": [
            {
                "name": "Haibo Xiang",
                "org": "1 Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Yu Wang",
                "org": "1 Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Hong Chang",
                "org": "1 Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Shenyu Yang",
                "org": "2 Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Mei Tu",
                "org": "2 Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Xianrong Zhang",
                "org": "3 Department of Orthopaedics, Chifeng Hospital, Inner Mongolia, China."
            },
            {
                "name": "Bin Yu",
                "org": "1 Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            }
        ],
        "venue": "Journal of biomaterials applications",
        "year": 2019
    },
    "cHS0phlS": {
        "id": "cHS0phlS",
        "title": "Construction and significance of finite element model of human ankle with complete anatomical structure",
        "abstract": "Objective To establish a three-dimensional(3D) finite element(FE) model of huaman ankle with intact bones and ligaments structure to provide a digital platform for ankle joint biomechanics research.Methods Right foot of a normal young man was scanned by CT.Mimics software was used to reconstruct the 3D structure of bones and external soft tissue,after processing by FreeForm and SolidWorks importing to ANSYS and Workebench modules,respectively,the 3D FE ankle models was developed and meshed.Meanwhile,an articular cartilage,ligaments,plantar fascia,crural interosseous membrane were simulated in the model according to anatomic characteristics and literature reviews,then the model was loaded and verified.Results Two 3D FE models of normal human right ankle joint including bones and soft tissue were established by two different methods.The loading result of models were consistent with the corresponding data by comparison.Conclusion The FE ankle models established has complete structures and validity,which can be the basic anatomic structure and mechanical properties of the human ankle.",
        "keywords": [
            "finite element method",
            "ankle joint",
            "biomechanics"
        ],
        "authors": [
            {
                "name": "LIU Qing-hua",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou ,P.R.China"
            },
            {
                "name": "YU Bin",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou ,P.R.China"
            },
            {
                "name": "JIN Dan",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou ,P.R.China"
            },
            {
                "name": "ZHANG Mei-chao",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou ,P.R.China"
            },
            {
                "name": "HU Yan-jun",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou ,P.R.China"
            },
            {
                "name": "WANG Dan",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou ,P.R.China"
            }
        ],
        "venue": "Shandong Medical Journal",
        "year": 2010
    },
    "FtlEDh3K": {
        "id": "FtlEDh3K",
        "title": "Plate versus intramedullary nail fixation in the treatment of humeral shaft fractures: an updated meta-analysis.",
        "abstract": "Regarding the treatment of humeral shaft fractures, the choice of plating or intramedullary nailing remains controversial. Previous randomized controlled trials and meta-analyses failed to draw a unanimous conclusion. To guide clinical decision making, we conducted an updated meta-analysis on the optimal treatment of humeral shaft fractures.We identified eligible studies published from 1969 to July 2011 using the Cochrane Library; Cochrane Bone, Joint and Muscle Trauma Group; MEDLINE; Embase; OVID; and Google Scholar and manually searched the references of relevant studies. Randomized controlled trials that compared nailing and plating in the treatment of humeral shaft fractures were included. After the methodologic assessment, available data were extracted and statistically reviewed. The primary outcomes were nonunion, delayed union, postoperative infection, reoperation, and radial nerve palsy. The secondary outcomes were restriction of shoulder motion, shoulder impingement, iatrogenic fracture comminution, and implant failure.We included 10 studies comparing plating and nailing in patients with humeral shaft fractures, comprising 439 participants. Plating reduced the risk of shoulder impingement and shoulder restriction in comparison with nailing. Regarding reoperation risk, a secondary sensitivity analysis showed the finding favoring plating over nailing remained unstable. Otherwise, no significant differences were found in postoperative infection, nonunion, delayed union, radial nerve palsy, iatrogenic fracture comminution, and implant failure between groups.On the basis of current evidence, both plating and nailing can achieve a similar treatment effect on humeral shaft fractures, but plating may reduce the occurrence of shoulder problems. Randomized controlled trials with larger sample sizes using appropriate blinding methods are needed to confirm these findings.Level II, Meta-analysis of prospective comparative trials.",
        "keywords": [
            "intramedullary nail",
            "humeral fractures",
            "bone plates",
            "fracture fixation",
            "level ii",
            "meta-analysis of prospective comparative trials"
        ],
        "authors": [
            {
                "name": "Hanbin Ouyang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jun Xiong",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Peng Xiang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Zhuang Cui",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Liguang Chen",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]",
        "year": 2013
    },
    "lgSmyeYq": {
        "id": "lgSmyeYq",
        "title": "Clinical significance and morphological measurements of Tibia medullary cavity in Tibet mini-pigs",
        "abstract": "Objective To compare the advantages and disadvantages of three methods in the morphological measurements and explore the morphological characteristics of the tibia medullary cavity in Tibet mini-pigs.Methods Tibia specimens were collected from thirty Tibet mini-pigs.Measurement of the length,arc as well as the coronal and sagittal width of the narrowest point of the tibial medullary cavity was carried out through plain radiography and CT 3-dimensional reconstruction or and directly in the specimens Data were recorded and processed using appropriate statistic methods.Results The main morphological characteristics of the tibial medullary cavity in Tibet mini-pigs is being triangular and elliptical in shape in the proximal and distal ends,respectively,and being intermediate in shape in the middle segment.The length of the medullary cavity measured by X-ray,CT and specimen were(11.75 ±0.58)cm,(11.58 ±0.55)cm and(11.70 ±0.65)cm,respectively.(P=0.524).Measurements of the coronal width of the narrowest point were 0.88±0.08 cm,0.84±0.06 cm,0.85±0.07cm,respectively(P=0.032).No significant differences were detected in the measurements of the arc of tibial medullary cavity(26.89±0.50°,26.06±0.49°,26.50±0.42°,P=0.106).Conclusion The accuracy of measurement through CT 3-dimensional reconstruction is higher than that through plain radiography.and the results of measurement through CT 3-dimensional reconstruction is closer to measurement directly performed in specimens.Therefore,data measured through CT 3-dimensional reconstruction are recommended for scientific research.The shape of the tibia medullary cavity in Tibet mini-pigs is similar to the human's,making it suitable for designing new intramedullary nails.",
        "keywords": [
            "Tibet mini-pigs",
            "Intramedullary nail",
            "Three-dimensional reconstruction of CT",
            "Tibia medullary cavity"
        ],
        "authors": [
            {
                "name": "DONG Fu",
                "org": " Department of Traumatology and Orthopaedics,The First Affilated Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "ZHANG Sheng",
                "org": " Department of Traumatology and Orthopaedics,The First Affilated Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "JIANG Nan",
                "org": " Department of Traumatology and Orthopaedics,The First Affilated Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "CHEN An-fu",
                "org": " Department of Traumatology and Orthopaedics,The First Affilated Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": " Department of Traumatology and Orthopaedics,The First Affilated Hospital of Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Anatomy",
        "year": 2013
    },
    "lPwCof1o": {
        "id": "lPwCof1o",
        "title": "Finite element analysis of the initial stability of subtalar arthrodesis with double-screw fixation]",
        "abstract": "To assess the optimal configuration of double-screw fixation for subtalar arthrodesis using finite element analysis.Three-dimensional finite element double-screw models of subtalar arthrodesis were reconstructed using Mimics 13.0, Geomagic 10.0 and solid works software based on the 3-D images of the volunteer's right foot. The external and internal rotation torques of 4 N·m were applied, and the micromotion at the bone-to-bone interface were measured to evaluate the initial stability of subtalar arthrodesis.A neck screw plus an anterolateral dome screw was the most stable model. The peak micromotion at the fusion site of this fixation configuration were 41.67mnplus;0.49 and 42.64mnplus;0.75 µm in response to the respectively. A neck screw plus a posteromedial dome screw was the least stable model, with peak micromotion at the bone-to-bone interface of 61.76mnplus;1.00 and 62.32mnplus;0.90 µm, respectively.A neck screw plus an anterolateral dome screw is the best fixation configuration while a neck screw plus a posteromedial screw provides the least stability of subtalar arthrodesis. Three-dimensional finite element models allow effective preoperative planning of the screw number and placement.",
        "keywords": [
            "finite element analysis",
            "subtalar arthrodesis",
            "internal fixation",
            "initial stability"
        ],
        "authors": [
            {
                "name": "Zhuang Cui",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Bin Yu",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Xue Li",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Changpeng Xu",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Jinqi Song",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Hanbin Ouyang",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Xicai Diao",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Liguang Chen",
                "org": " Department of Orthopedics and Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2012
    },
    "TxWwugJu": {
        "id": "TxWwugJu",
        "title": "Effects of different concentrations ozone on synovitis in rat with rheumatoid arthritis",
        "abstract": "[Objective]To observe the therapeutic effect of ozone (O3) of different concentrations on rat with rheumatoid arthritis (RA).[ Method ]Forty-eight Wistar rats were randomly divided into 8 groups. There are 5 ozone groups which were marked by 10μg/ml,20μg/ml,30μg/ml,40μg/ml and 50μg/ml respectively,control group,oxygen group and RA model group.All rats were induced RA by hypodermic injection of collagen Ⅱ and complete Freund's adjuvant except that in the control group.At21 days after modeling,the rats in oxygen group were given an injection of oxygen in the knee joint cavity weekly for 3 weeks,and the rat in ozone groups were injected the concentration of ozone as they marked weekly for 3 weeks.The swelling and thickness of hind paw,as well as the morphological changes of synovium were observed.[Result]The swelling peak appeared at the 21stday after modeling (P<0.01).There was no swelling in O3-40 group after3-week injection.And the proliferation and inflammatory infiltration of synovial in O3-40 group was not obvious.What's more,there was no significant difference in the thickness of hind pawbetween control group and O3-40 group.[Conclusion]Intraarticular injection of 40μg /ml O3 can inhibit the synovitis of rats with RA.",
        "keywords": [
            "ozone",
            "synovial hyperplasia",
            "rheumatoid arthritis",
            "synovitis",
            "rat"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ",CHENHui-qiang,LUChang-huai,et al. Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University, Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2011
    },
    "TrRkr8ap": {
        "id": "TrRkr8ap",
        "title": "Effects of exercise of different intensity on early repair of full-thickness articular cartilage defects and expressions of MMP-3 and TIMP-1 in rats]",
        "abstract": "To evaluate the effects of treadmill running exercise of different intensity on early repair of full-thickness defects on the patellofemoral articular surface and the changes in the expressions of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in SD rats.Twenty-four male SD rats with full-thickness defects on the patellofemoral articular surface were randomly assigned into sedentary control (SED) group and low-, moderate- and high-intensity running groups (LIR, MIR, and HIR groups, respectively). The running groups were trained on treadmill for 6 consecutive weeks. Blood samples were collected to detect serum MMP-3 and TIMP-1 levels using ELISA before and after the experiment, and the femoral trochlea were collected to assess tissue repair by gross appearance scoring and O Driscoll histological scoring with Safranine O-Fast Green staining and Toluidine blue staining.In rats in SED group, the defect was filled with hyaline articular cartilage-like tissues, as compared to fibrous tissues in LIR and MIR groups and subchondral bone damage in HIR group. The SED group scored the highest and HIR group the lowest among the 4 groups in gross appearance scoring and O Driscoll histological scoring. No significant differences were found in MMP-3 or TIMP-1 levels among the groups before training (P>0.05), but after 6 weeks of training, serum MMP-3 and TIMP-1 levels differed significantly among the 4 groups (P<0.05), and all the 3 running groups had a significantly higher MMP-3 level than the control group (P<0.05). After the 6-week training, TIMP-1/MMP-3 ratio was significantly higher in SED group than in the 3 running groups, and was the lowest in HIR group.Both low- and moderate-intensity exercise failed to promote resurfacing of full-thickness cartilage defects on the patellofemoral articular surface in rats, and high-intensity exercise even induces subchondral bone damage. The expression of MMP-3 and TIMP-1 is related to exercise, and the TIMP-1/MMP-3 ratio reflects the extent of tissue repair.",
        "keywords": [],
        "authors": [
            {
                "name": "Fu Dong",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: df96502@163.com."
            },
            {
                "name": "Jinqi Song",
                "org": ""
            },
            {
                "name": "Jiwei Luo",
                "org": ""
            },
            {
                "name": "Peiran Zhao",
                "org": ""
            },
            {
                "name": "Guoxin Ni",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2014
    },
    "62NB59dG": {
        "id": "62NB59dG",
        "title": "Effects of ozone water on endogenous growth factors content in infected wound",
        "abstract": "Objective To study the effects of ozone water treatment on the expression of endogenous growth factors in infected wound and reveal the mechanism of anti-inflammatory and wound healing of ozone water. Methods 50 vista rats were randomly divided into five groups:5 mg / L,10 mg / L,20 mg / L ozone water treatment group,chlorhexidine treatment group,and sham operation group. Infected wounds were artificially created in the back and leg of rats. 48 hours after the establishment of infection,the rats from different treatment groups were treated with chlorhexidine or ozone water once a day for 9 days respectively. The alteration of infected wound was observed at the 3rd,6th and 9th day after corresponding treatment. And the expression level of endogenous epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α) in infected wound were analyzed by ELISA assay. Result The results revealed that the expression of EGF in ozone water treated groups were much higher than those in chlorhexidine treated group and sham operation group. But the expression of TNF-α in ozone water treated groups is reduced compared to sham operation group and chlorhexidine treated group. Conclusion The effects of ozone water treatment on EGF and TNF-α are helpful to the repairment of infected wound.",
        "keywords": [
            "Ozone water",
            "Wounds and injuries",
            "Tumor necrosis factor alpha",
            "Epidermal growth factor"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ". Department of Orthopedic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hua-jun",
                "org": ". Department of Orthopedic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LIN Qing-rong",
                "org": ". Department of Orthopedic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "WANG Bo-wei",
                "org": ". Department of Orthopedic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "CHEN Hui-qiang",
                "org": ". Department of Orthopedic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2010
    },
    "QTyfTDjm": {
        "id": "QTyfTDjm",
        "title": "Mechano-regulatory cellular behaviors of NIH/3T3 in response to the storage modulus of liquid crystalline substrates",
        "abstract": "The extent of substrate stiffness has been shown to be predominant in regulating cellular behaviors. Previous studies have used matrices such as elastomers or hydrogels to understand cell behavior. Herein, liquid crystalline matrices that resemble movable morphology of biomembrane and viscoelasticity were fabricated with tunable storage modulus for the evaluation of the modulus-driven cell behaviors. Our results demonstrated that NIH/3T3 cells showed a hypersensitive response to the storage modulus of liquid crystalline substrates by the alteration in attachment, spreading, proliferation and viability, polarization, cell cycle and apoptosis, and activity of mechano-transduction-related signal molecules including FAK, paxillin and ERK. The octyl hydroxypropyl cellulose substrates (OPC-1-5) with intermediate storage modulus of 12,312Pa and 7228Pa (OPC-2 and OPC-3 respectively) could provide more beneficial adhesion conditions leading to a larger spreading area, more elongated morphology and higher proliferation rates possibly through paxillin-ERK pathway, whereas the substrates with the highest or lowest storage modulus (16,723Pa, OPC-1; and 41Pa, OPC-5, respectively) appeared unfavorable for cell growth. Our study provides insights into the mechanism of modulus-driven cellular behaviors for better design of bioengineered cell substrates.",
        "keywords": [
            "Liquid crystal",
            "Mechano-transduction",
            "Storage modulus",
            "Cell adhesion",
            "Cell morphology",
            "Cell proliferation"
        ],
        "authors": [
            {
                "name": "Yang Chen",
                "org": "Department of Materials Science and Engineering, PR China"
            },
            {
                "name": "Lei Wang",
                "org": "Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China"
            },
            {
                "name": "Hao Huang",
                "org": "Huadu District People׳s Hospital Affiliated of Southern Medical University, Guangzhou 510800, PR China"
            },
            {
                "name": "Ruizhe Tan",
                "org": "Department of Materials Science and Engineering, PR China"
            },
            {
                "name": "Jupeng Zhao",
                "org": "Department of Materials Science and Engineering, PR China"
            },
            {
                "name": "Shenyu Yang",
                "org": "Department of Materials Science and Engineering, PR China"
            },
            {
                "name": "Rong Zeng",
                "org": "Department of Materials Science and Engineering, PR China"
            },
            {
                "name": "Hao Wu",
                "org": "The First Affiliated Hospital, Jinan University, Guangzhou 510632, PR China"
            },
            {
                "name": "Jiaqing Zhang",
                "org": "School of Medicine, Jinan University, Guangzhou 510632, PR China"
            },
            {
                "name": "Bin Yu",
                "org": "Nanfang Hospital, Southern Medical University, Guangzhou 510515, PR China"
            },
            {
                "name": "Mei Tu",
                "org": "Department of Materials Science and Engineering, PR China"
            }
        ],
        "venue": "Journal of the Mechanical Behavior of Biomedical Materials",
        "year": 2016
    },
    "TC7jqB4v": {
        "id": "TC7jqB4v",
        "title": "Strontium‑containing α‑calcium sulfate hemihydrate promotes bone repair via the TGF‑β/Smad signaling pathway.",
        "abstract": "Calcium phosphate‑based bone substitutes have been widely used for bone repair, augmentation and reconstruction in bone implant surgery. While some of these substitutes have shown excellent biological efficacy, there remains a need to improve the performance of the current calcium phosphate‑based bone substitutes. Strontium ions (Sr) can promote new osteogenesis, inhibit osteoclast formation and increase osteoconductivity. However, the therapeutic effect and mechanism of strontium‑containing α‑calcium sulfate hemihydrate (Sr‑CaS) remains unclear. The present study created bone injuries in rats and treated the injuries with Sr‑CaS. Then Cell Counting Kit‑8, soft agar colony formation, flow cytometry, Transwell and Alizarin Red staining assays were performed to assess the bone cells for their proliferation, growth, apoptosis, invasion, and osteogenic differentiation abilities. The bone reconstructive states were measured by the microCT method, hematoxylin and eosin staining and Masson staining. Bone‑related factors were analyzed by the reverse transcription‑quantitative PCR assay; transforming growth factor (TGF)‑β, mothers against decapentaplegic homolog (Smad)2/3 and β‑catenin expression was measured by western blot analysis and osteocalcin (OCN) expression was assessed by immunohistochemistry. Sr‑CaS did not significantly affect the proliferation and apoptosis of bone marrow stem cells (BMSCs), but did accelerate the migration and osteogenic differentiation of BMSCs in vitro. Sr‑CaS promoted bone repair and significantly increased the values for bone mineral density, bone volume fraction, and trabecular thickness, but decreased trabecular spacing in vivo in a concentration‑-dependent manner. In addition, Sr‑CaS dramatically upregulated the expression levels of genes associated with osteogenic differentiation (Runt‑Related Transcription Factor 2, Osterix, ALP, OCN and bone sialoprotein) both in vitro and in vivo. Sr‑CaS also increased Smad2/3, TGF‑β and phosphorylated‑β‑catenin protein expression in vitro and in vivo. These results indicated that materials that contain 5 or 10% Sr can improve bone defects by regulating the TGF‑β/Smad signaling pathway.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhi Liu",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Zewei Yu",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Hong Chang",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Yu Wang",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Haibo Xiang",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Xianrong Zhang",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2019
    },
    "P2dU6DrV": {
        "id": "P2dU6DrV",
        "title": "Effect of intra-articular ozone injection on degenerative knee cartilage in rats",
        "abstract": "This study explored the therapeutic effects of medical ozone on cartilage in animal models of osteoarthritis (OA). Forty healthy adult Sprague-Dawley rats were randomly divided into five equal groups: group A (normal), group B (model), group C (air), group D (35μg/ml O 3) and group E (70 μg/ml O 3). OA models were created by transecting the anterior cruciate ligament (ACL) and excising a third of the medial meniscus in groups B, C, D and E. Air was injected into the joints in group C. Ozone with 35 μg/ml O 3 and 70 μg/ml O 3 were injected into the joints in groups D and E respectively every other day, with 1-1.5 ml each time. Injections were made altogether for two weeks at one week intervals. The animals were killed after four weeks to harvest condylar cartilage of femur for HE staining and observation under a transmission microscope. Mankin's indexes were recorded. Douche fluids from the diseased joints were obtained for measurement of superoxide dismutase (SOD) and malondialdehyde (MDA). In OA models of group B, obviously degenerative changes were observed under microscopy, resulting in mostly blue and green color destaining of Masson staining in superficial cartilage. The activity of SOD in the douche fluid from the diseased joints decreased and the quantity of MDA in the serum increased. Mankin's indexes in group D were significantly higher than those in groups B and C (P<0. 05), but not significantly different from those in group A. SOD levels were increased and MDA levels decreased. There were no significant differences between groups E and B in Mankin's indexes. SOD levels decreased and MDA levels increased. 35 μg/ml O 3 can prevent degeneration of articular cartilage and improve the ability to clear free radicals, but 70 μg/ml O 3 may result in peroxidatic reaction of tissue and cells, leading to articular cartilage damage.",
        "keywords": [
            "Cartilage",
            "MDA",
            "Osteoarthritis",
            "Ozone",
            "SOD"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Qingrong Lin",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Qiaohua Zhu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xiaofeng He",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "International Journal of Ozone Therapy",
        "year": 2010
    },
    "ynaEl9aG": {
        "id": "ynaEl9aG",
        "title": "3D digitalization of the proximal tibia and its significance on designing the tibial component of total knee arthroplasty",
        "abstract": "Objective ToexplorethepreferableprosthesisdesignforChinesepeople,byanalyzingthe normal linear parameters of normal proximal tibia. Methods Original CT image data were used to set up three-dimensional model of normal knees. The related linear parameters of different proximal tibia sections were measured and compared,involving the mediolateral (ML),middle anteroposterior (AP),medial and lateral anteroposterior dimensions and the aspect ratio (AP /ML) of the resected proximal tibial surface. Results Positive correlation appeared between AP and ML on the proximal tibia section,which were (49.87±3.9)mm and (73.50±5.6)mm respectively. The AP and ML of male on the tibial plateau were (53.24±4.1)mm and (75.85±3.5)mm,which was more large than that of female of (47.61±3.7)mm and (67.68±2.6)mm respectively. The MAP was larger than LAP,which were (3.9±2.9)mm,and (3.7±2.7)mm for male and female respectively. Conclusions The geometry and anatomy of the knee is variable,regardless of gender and human race,which should be considered carefully during the design process of the tibia prosthesis for the total knee arthroplasty.",
        "keywords": [
            "Computertomography",
            "Tibia",
            "Measurement",
            "Totalkneearthroplasty"
        ],
        "authors": [
            {
                "name": "HU Yan-jun",
                "org": ",et al. Department of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al. Department of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LUO Ji-wei",
                "org": ",et al. Department of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Anatomy",
        "year": 2010
    },
    "uC6oKdO9": {
        "id": "uC6oKdO9",
        "title": "Effects of ozone on IL-1 and TNF-α in rabbit articular synovium",
        "abstract": "[Objective]To observe the effect of ozone in different concentrations on proinflammatory cytokines IL-1 and TNF-α in rabbit articular synovium,and therefore to explore the mechanism of ozone-therapy for osteoarthritis.[Method]Sixty-four New Zealand white rabbits were randomly divided into 8 groups:the ozone groups of 10 μg/ml,20 μg/ml,30 μg/ml,40 μg/ml and 50 μg/ml,normal group,oxygen group and model group.All the rabbits were made osteoarthritis models expect in the normal group.The oxygen group was given an injection of 2 ml pure oxygen in the knee joint cavity weekly for 3 weeks.And the ozone groups received the concentrations of ozone weekly for 3 weeks.Then articular synovium morphology was observed,and IL-1 and TNF-α in the synovium were detected.[Result]The decrease of articular synovium was seen in ozone groups,and synovial tissue atrophy as well as apoptosis was found under the pathological section with mild infiltration of inflammatory cells.The distribution of IL-1 and TNF-α agreed with the experiment results,which was:ozone 50 μg/ml group>oxygen group and model group>ozone 40 μg/ml group>ozone 10 μg/ml group and 30 μg/ml group>ozone 20 μg/ml group>control group.[Conclusion]Ozone can affect IL-1 and TNF-α in articular synovium.Ozone of low concentration could delay the progression of osteoarthritis,but the higher concentration may be harmful.",
        "keywords": [
            "TNF-α",
            "IL-1",
            "ozone",
            "osteoarthritis"
        ],
        "authors": [
            {
                "name": "LIN Qing-rong",
                "org": ",et al.Department of Trauma & Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Trauma & Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "CHEN Hui-qiang",
                "org": ",et al.Department of Trauma & Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2011
    },
    "ZpW1OZtL": {
        "id": "ZpW1OZtL",
        "title": "Proximal Femoral Nails Versus Dynamic Hip Screws in Treatment of Intertrochanteric Fractures of Femur in Adults:A Systematic Review",
        "abstract": "Objective To compare the efficacy of proximal femoral nails(PFN) versus dynamic hip screws(DHS) in the treatment of intertrochanteric fractures of femur in adults.Methods Cochrane library,Medline,Embase and Chinese Biomedical Database were searched for randomized controlled trials(RCT) and Controlled Clinical Trials(CCT) comparing PFN with DHS in the management of intertrochanteric fractures of femur from 1996 to 2010.Furthermore,the relevant references were also searched manually.Methodology quality of the trials was critically assessed and relative data were extracted.Statistical software Revman 4.2.10 was used for data-analysis.Results Seven RCT involving 758 cases were included.The results of Meta-analysis showed that no statistically significant differences were found in the postoperative wound infection,lag screw cut-out,reoperation,postoperative femoral shaft fractures,nonunion between PFN and DHS.However,compared with DHS,PFN may shorten the operation time,reduce the intraoperative blood loss and be with shorter incision length.Conclusion Compared with DHS,PFN may shorten the operation time,reduce the intraoperative blood loss and be with shorter incision length.However,more high quality,large-scale randomized controlled trials are required for accurate conclusion.",
        "keywords": [
            "Dynamic hip screws (DHS)",
            "Intertrochanteric fractures of femur",
            "Proximal femoral nails (PFN)",
            "Systematic review"
        ],
        "authors": [
            {
                "name": "Zhang Kairui",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,"
            },
            {
                "name": "Yu Bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,"
            },
            {
                "name": "Dai Haifei",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,"
            }
        ],
        "venue": "Chinese Journal of Bone and Joint Injury",
        "year": 2011
    },
    "0E1fE0Ff": {
        "id": "0E1fE0Ff",
        "title": "Measurement of proximal tibia in normal Chinese people with digital three-dimensional reconstruction technique",
        "abstract": "[Objective]To obtain the normal linear parameters of different resection levels of normal proximal tibia in Chinese people, and discuss the influence of the gender and resection level on the design of the tibia prosthesis. [Methods]Thirty-six normal Chinese people (36 left knees, 18 males and 18 females), with an average age of 43 years (range 18～55 years) were enrolled in this study.Original CT image data were used to set up three-dimensional model of Chinese normal knees.The related linear parameters of different proximal tibia sections were measured and compared.[Results]Parameters of mediolateral (ML) ,medial and latera anteroposteriordimensions(MAP/ LAP) and the aspect ratio(AP/ML) of the resect proximal tibia surface were obtained. The parameters were confirmed by statistics analysis.[Conclusion]The geometry and anatomy of the knee in Chinese people have significant differences from the western people.The prosthesis designed by western people should be choosen carefully.Sex and resection levels should be taken into account in designing tibia prosthesis and or choosing the imported prosthesis in the total knee arthroplasty.",
        "keywords": [
            "total knee arthroplasty",
            "sex",
            "prosthesis",
            "resection",
            "proximal tibia",
            "orthopaedics",
            "physical models",
            "measurement"
        ],
        "authors": [
            {
                "name": "LI Yu-jun",
                "org": ",et al. Orthopaedic Department, Guangzhou Nanfang Hospital, Southern Medical University, Guangzhou ,, China"
            },
            {
                "name": "YU bin",
                "org": ",et al. Orthopaedic Department, Guangzhou Nanfang Hospital, Southern Medical University, Guangzhou ,, China"
            },
            {
                "name": "LUO Biao",
                "org": ",et al. Orthopaedic Department, Guangzhou Nanfang Hospital, Southern Medical University, Guangzhou ,, China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2009
    },
    "OO5CjlZF": {
        "id": "OO5CjlZF",
        "title": "Lentivirus‑mediated microRNA‑26a overexpression in bone mesenchymal stem cells facilitates bone regeneration in bone defects of calvaria in mice.",
        "abstract": "Repair of bone defects presents a serious clinical challenge as it is difficult to restore bone function and regenerate bone loss. In the present study, the effects of lentivirus‑mediated transfection of bone marrow mesenchymal stem cells (BMSCs) with microRNA (miR)‑26a on bone regeneration were investigated in a mouse bone defect repair model. Marker of proliferation Ki67 (Ki67) staining was employed to detect the cell proliferation capacity and alkaline phosphatase (ALP) staining was used to investigate osteogenic differentiation. A mouse model of cranial bone defects was established. β‑tricalcium phosphate biomaterials co‑cultured with the transfected BMSCs were implanted into the defect areas of mouse models. Micro‑computed tomography, and hematoxylin and eosin and toluidine blue staining, were used to detect bone regeneration in the defect areas and the degradation of scaffolds. miR‑26a expression, and the mRNA and protein expression of osteogenesis‑associated cytokines, were detected using reverse transcription‑quantitative polymerase chain reaction and western blot analysis. Separated and cultured BMSCs highly expressed CD29 and CD105, but not CD34 and CD45, as determined by flow cytometry. miR‑26a expression and the positive cell rate of Ki67 and ALP staining in BMSCs transfected with pLVTHM‑miR‑26a were increased. The BMSC and negative control‑transfected BMSC groups exhibited increased bone regeneration in the defect areas, increased bone volume of newly formed bones, and elevated mRNA and protein expression of runt‑related transcription factor 2 (Runx2) and osteocalcin (OC), compared with the blank group. However, the miR‑26a‑transfected BMSC group exhibited further increases in bone regeneration and the volume of newly formed bones, and further elevations of the mRNA and protein expression levels of Runx2 and OC. The present findings demonstrated that lentivirus‑mediated modification of BMSCs enhanced bone regeneration during the repair of cranial bone defects in mice.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhi Liu",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Hong Chang",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Yihong Hou",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Yu Wang",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            },
            {
                "name": "Zhiqiang Zhou",
                "org": "Department of Surgery II, People's Hospital of Dongsheng, Ordos City, Inner Mongolia 017000, P.R. China."
            },
            {
                "name": "Ming Wang",
                "org": "Department of Surgery II, People's Hospital of Dongsheng, Ordos City, Inner Mongolia 017000, P.R. China."
            },
            {
                "name": "Zhidong Huang",
                "org": "Department of Surgery II, People's Hospital of Dongsheng, Ordos City, Inner Mongolia 017000, P.R. China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2018
    },
    "q9kUgV4c": {
        "id": "q9kUgV4c",
        "title": "Differentially Expressed Genes in Osteomyelitis Induced by Staphylococcus aureus Infection.",
        "abstract": "Osteomyelitis (OM) is a complicated and serious disease and its underlying molecular signatures of disease initiation and progression remain unclear.  is the most common causative agent of OM. Previous study of Banchereau et al. has established a link between whole blood transcription profiles and clinical manifestations in patients infected with . However, the differentially expressed genes (DEGs) in OM induced by  infection have not been intensively investigated. In this study, we downloaded the gene expression profile dataset GSE30119 from Gene Expression Omnibus, and performed bioinformatic analysis to identify DEGs in  infection induced OM from the transcriptional level. The study consisted of 143 whole blood samples, including 44 healthy controls, 42 OM-free, and 57 OM infection patients. A total of 209  infection-related genes (SARGs) and 377 OM-related genes (OMRGs) were identified. The SARGs were primarily involved in the immune response by GO functional and pathway enrichment analysis. Several proteins adhere to neutrophil extracellular traps may be critical for the immune response to the process of  infection. By contrast, the OMRGs differ from the SARGs. The OMRGs were enriched in transmembrane signaling receptor and calcium channel activity, cilium morphogenesis, chromatin silencing, even multicellular organism development. Several key proteins, including PHLPP2 and EGF, were hub nodes in protein-protein interaction network of the OMRGs. In addition, alcoholism, systemic lupus erythematosus and proteoglycans in cancer were the top pathways influenced by the OMRGs associated with OM. Thus, this study has further explored the DEGs and their biological functions associated with  infection and OM, comparing with the previous study, and may light the further insight into the underlying molecular mechanisms and the potential critical biomarkers in OM development.",
        "keywords": [
            "Staphylococcus aureus (S. aureus)",
            "bioinformatic analysis",
            "candidate biomarkers",
            "differentially expressed genes (DEGs)",
            "osteomyelitis (OM)"
        ],
        "authors": [
            {
                "name": "Peisheng Chen",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Zilong Yao",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Ganming Deng",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Yilong Hou",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Siwei Chen",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Yanjun Hu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Bin Yu",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            }
        ],
        "venue": "Frontiers in microbiology",
        "year": 2018
    },
    "fTgV9QCf": {
        "id": "fTgV9QCf",
        "title": "Osteogenic and angiogenic effects of endothelial cells and osteoblasts co-cultured at different ratios",
        "abstract": "BACKGROUND:Recent studies have shown that co-cultured endothelial cells and osteoblasts are mutually promotive in bone tissues repair.OBJECTIVE:To observe the effects of co-culture of endothelial cells and osteoblasts at different ratios on vasculogenesis and bone formation.METHODS:Human umbilical vein endothelial cells and osteoblasts MG63 were isolated and cultured.Endothelial cells were co-cultured with osteoblasts at ratios of 1:0,8:1,4:1,1:1,1:4,1:8,0:1 in a 24-well plate,and monolayers of endothelial cells and osteoblasts were cultured alone respectively as controls.At 7,14,21 days after co-culture,cells growth condition,vascular endothelia growth factor level and alkaline phosphatase activity were observed and detected in each group.RESULTS AND CONCLUSION:Cells grew well in each group in 21 days.At day 14,in the 1:8 group,osteoblasts began to cluster together.At day 21,the 1:4 group showed significantly more calcification nodules formed by Alizarin red staining than the 1:8 group,and no calcification nodules were seen in osteoblasts cultured alone.Alkaline phosphatase activity in the 1:4 group was significantly increased at the three time points (P < 0.05).The level of vascular endothelia growth factor in the 1:4 group began to increase at day 7 and reached its peak at day 21.These findings suggest that angiogenic effect is more effective when endothelial cells are co-cultured with osteoblasts at the ratio of 4:1,and osteogenic effect is more effective at the ratio of 1:4.",
        "keywords": [],
        "authors": [
            {
                "name": "Hao Zeng-tao",
                "org": "Department of Orthopedic Trauma,Nanfang Hospital Affiliated to Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Feng Wei",
                "org": "Department of Orthopedics,Second Affiliated Hospital of Inner Mongolia Medical College,Hohhot ,Inner Mongolia Autonomous Region,China"
            },
            {
                "name": "Hao Ting",
                "org": "Department of Orthopedics,Second Affiliated Hospital of Inner Mongolia Medical College,Hohhot ,Inner Mongolia Autonomous Region,China"
            },
            {
                "name": "Yu Bin",
                "org": "Department of Orthopedic Trauma,Nanfang Hospital Affiliated to Southern Medical University,Guangzhou ,Guangdong Province,China"
            }
        ],
        "venue": "Chinese Journal of Tissue Engineering Research",
        "year": 2012
    },
    "r5KP3Sw0": {
        "id": "r5KP3Sw0",
        "title": "Are platelet concentrates an ideal biomaterial for arthroscopic rotator cuff repair? A meta-analysis of randomized controlled trials.",
        "abstract": "The present study aims to conduct a meta-analysis of Level I evidence studies to investigate the efficacy of concomitant platelet concentrate (PC) used in arthroscopic rotator cuff repair.We systematically searched electronic databases to identify randomized controlled trials (RCTs) evaluating the role of PC augmentation in arthroscopic rotator cuff repairs for patients with full-thickness tears. The search strategy followed the requirements in the Cochrane Library Handbook. The primary outcome was retearing of the rotator cuff. Functional outcomes were analyzed in terms of Constant score, specific Constant pain score, University of California, Los Angeles (UCLA) shoulder score, Simple Shoulder Test (SST) score, and American Shoulder and Elbow Surgeons (ASES) score.Seven studies with a total of 417 patients available at the latest follow-up reporting data about retears were analyzed in this meta-analysis. However, 4 studies with Constant scores (n = 237), 3 studies with UCLA scores (n = 168), 2 studies with Constant pain scores (n = 164), 2 studies with ASES scores (n = 101), and 2 studies with SST scores (n = 121) were analyzed. The retear rates and functional scores showed that there was no significant efficacy of PC application in arthroscopic rotator cuff repairs.This meta-analysis of high-level evidence suggests that PCs have no benefit regarding retear rate and overall clinical outcomes for the arthroscopic repair of full-thickness rotator cuff tears.Level II, meta-analysis of randomized controlled trials.",
        "keywords": [],
        "authors": [
            {
                "name": "Xue Li",
                "org": "Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China; Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Chang-Peng Xu",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Yi-Long Hou",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Jin-Qi Song",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Zhuang Cui",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            }
        ],
        "venue": "Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association",
        "year": 2014
    },
    "eRd08u10": {
        "id": "eRd08u10",
        "title": "Effect of ozone water on the inflammation and repair in infected wounds]",
        "abstract": "To study the effect of ozone water in promoting the healing of infected wounds.Fifty Wistar rats were randomly divided into 5 groups, namely chlorhexidine treatment group, 5, 10, and 20 mg/L ozone water treatment groups, and the control group without any treatment. Infected wounds were induced on the back of the rats, and at 48 h of infection, chlorhexidine or ozone water was applied once daily for 9 days. Before and at days 3, 6, and 9 of the treatment, the wound changes were observed. The WBC in the tail venous blood was detected and the incised skin and muscular tissues were pathologically examined. RESULTS AMD CONCLUSION: Ozone water showed better effects in promoting the healing of the infected wound, especially at higher doses of 10 and 20 mg/L.",
        "keywords": [
            "inflammation",
            "ozone water",
            "repair",
            "wound infection"
        ],
        "authors": [
            {
                "name": "Hua-jun Huang",
                "org": " Department Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Bin Yu",
                "org": " Department Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Qing-rong Lin",
                "org": " Department Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Bo-wei Wang",
                "org": " Department Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Hui-qiang Chen",
                "org": " Department Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2010
    },
    "kAggtzl9": {
        "id": "kAggtzl9",
        "title": "Treatment of large circular soft tissue defect in lower extremities with a combination of bridge flaps and free skin graft covered by vacuum sealing drainage]",
        "abstract": "To explore the surgical technique and clinical value of treatment for posttraumatic large circular soft tissue defect in the lower extremities using a combination of posterior tibial vascular bridge flap in the unaffected leg and skin graft covered by vacuum sealing drainage (VSD).From January 2008 to June 2010, 11 cases with posttraumatic large circular soft tissue defects with deep tissue exposed or partial necrosis in the lower extremities were treated by bridge flaps and combined with free skin graft covered by VSD. There are 7 males and 4 females, with an average age of 32.5 years (range from 15 to 52 years). The size of wound varied from 24 cm × 13 cm to 45 cm × 24 cm. After the wound were completely debrided, the external fixation or internal fixation was conducted for the patients with unstable fracture. Then VSD were used to covered the wound for 1-2 times with a period of 5 to 7 days according to the wound condition. After granulation tissue grew, bridge flap transplantation was performed to repair tissue defect and cover the exposed bone, which combined with skin graft covered by VSD was used to cover the residual wound. Survival rate and quality healing of the flaps were followed up postoperatively.The granulation growth of 11 cases with large circular soft tissue defect in the lower extremities associated tissue exposure was good after the application of VSD. All the cases were covered by free flap transplantation and skin grafting except for 6 cases due to large defect. The wound was covered by skin re-grafting in 4 cases and frequently dressing change in 2 cases. All the flaps were successful with good infection control and no sinus. The average period of follow-up was 10.6 months (5 - 24 months). All the patients were satisfied with the good outline and good function of the affected limb.Patients with posttraumatic large circular soft tissue defect in the lower extremities can be effectively treated with a combination of bridge flaps and free skin graft covered by VSD, which can shorten the course of treatment, and restore the function of affected extremities as much as possible.",
        "keywords": [],
        "authors": [
            {
                "name": "Gao-hong Ren",
                "org": "Department of Orthopaedics and Treumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. doctor020@163.com"
            },
            {
                "name": "Jian-wei Li",
                "org": ""
            },
            {
                "name": "Run-guang Li",
                "org": ""
            },
            {
                "name": "Gang Wang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2012
    },
    "WgZ26LY3": {
        "id": "WgZ26LY3",
        "title": "Clinical results of flap pedicled with collateral branch of descending rarus of lateral circumflex femoral artery for repairing lower limb soft tissue defects]",
        "abstract": "To investigate the clinical results of the flap pedicled with collateral branch of descending rarus of lateral circumflex femoral artery with digital three-dimensional reconstruction technique for lower limb soft tissue defects.Between March 2009 and January 2010, 7 patients with lower limb soft tissue defects were treated with free flap pedicled with collateral branch of descending rarus of lateral circumflex femoral artery. There were 6 males and 1 female with an age range from 6 to 51 years. They were injured by traffic accident (4 cases), or by object hit from height (3 cases). The locations were foot in 2 cases, ankle in 2 cases, and anterior tibia in 3 cases. The disease duration was 8 hours to 40 days (mean, 20 days). All the cases complicated by exposure of tendons or bones. The areas of soft tissue defect ranged from 12 cm x 7 cm to 20 cm x 14 cm. Free flaps were transplanted at 4 to 16 days after symptomatic treatment. Before operation, all the flaps were designed with digital three-dimensional reconstruction technique. The size of flaps ranged from 15 cm x 9 cm to 22 cm x 16 cm. The donor sites were closed directly in all cases.All the flaps survived. The wounds and incisions at donor sites healed by first intention. All the patients were followed up 6 to 12 months. The texture, appearance, and function of the flaps were satisfactory, and no complication occurred. All the flaps had protective sensation, which could meet the requirement of the daily life. The function of ankle was satisfactory with normal walk; the extension was 19-22 degrees and the flexion was 30-36 degrees. No obvious scar formed at donor sites.The flap pedicled with collateral branch of descending rarus of lateral circumflex femoral artery has reliable blood supply, easy operation, little influence on the donor site, and high success rate with digital three-dimensional reconstruction technique. It is an excellent option for repairing lower limb soft tissue defects.",
        "keywords": [
            "lateral circumflex femoral artery flap lower limb soft tissue defect three-dimensional reconstruction repair"
        ],
        "authors": [
            {
                "name": "Zhiwei Liu",
                "org": ".Department of Orthopedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China."
            },
            {
                "name": "Bin Yu",
                "org": ".Department of Orthopedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China."
            },
            {
                "name": "Chenghe Qin",
                "org": ".Department of Orthopedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China."
            },
            {
                "name": "Jiwei Luo",
                "org": ".Department of Orthopedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China."
            },
            {
                "name": "Yanjun Hu",
                "org": ".Department of Orthopedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China."
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2011
    },
    "47VShrqY": {
        "id": "47VShrqY",
        "title": "On the improvement of reviewers decision-making ability of clinical medicine journal editors in China",
        "abstract": "From factors affected the reviewers decision-making capacity of the editorial,Several initiatives to improve the reviewers decision-making capacity of the clinical medicine journals editors in China were elaborated: Strengthening the cultivation of expertise of the clinical medicine journals editors in China,including to encourage editor to learn,gain expertise from foreign magazines and the review list of the expert reviewers,participate in the doctor' s shift and rounds,consult professionals.Strengthening the quality training of clinical medicine journals editors,including to transfer the initiative of the clinical medicine journals editors and open the international perspective of the clinical medicine journals editors.",
        "keywords": [
            "clinical medicine",
            "science Journal",
            "editors",
            "review"
        ],
        "authors": [
            {
                "name": "NIE Lanying",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,,Guangzhou,China"
            },
            {
                "name": "YU Bin",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,,Guangzhou,China"
            },
            {
                "name": "JIN Dan",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,,Guangzhou,China"
            },
            {
                "name": "ZHANG Ning",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,,Guangzhou,China"
            }
        ],
        "venue": "Acta Editologica",
        "year": 2013
    },
    "iK5gxt0Y": {
        "id": "iK5gxt0Y",
        "title": "Protective effects of Ginkgo Biloba Extract 761 on atrophy of skeletal muscles in rat with limbs fixed",
        "abstract": "AIM: To study the preventive and therapeutic effects of ginkgo biloba extract 761 on disuse atrophy of skeletal muscles.METHODS: Twenty-four SD rats were divided into blank group,control group and experimental group,with 8 rats in each group.The right hind limbs of the rats were fixed for 4 weeks with compliant plaster from metatarsus to 1 cm upper knees,and the knee joints were fixed in 100° and ankle joint in 60° extension position.The rats in control group received administration of distilled water(3 mL),and the rats in experimental group received administration of ginkgo biloba extract 761(120 mg/kg,14 g/L).After 4 weeks,gastroenemius muscles in right hind limb were dissected and measured for the contractility,wet weight,protein content,Na+-K+-ATPase and Ca2+-ATPase activities.RESULTS: Compared with blank group,contractility,wet weight,protein content,Na+-K+-ATPase and Ca2+-ATPase activities of gastroenemius muscles in control and experimental groups significantly decreased(P<0.05).Compared with control group,the above parameters of gastroenemius muscle were obviously improved in experimental group(P<0.05).CONCLUSION: Ginkgo biloba extract 761 can improve contractility,wet weight,protein content,Na+-K+-ATPase and Ca2+-ATPase activities in disuse atrophy of skeletal muscles,suggesting that Ginkgo biloba extract 761 has preventive and protective effects on development of disuse atrophy of skeletal muscles.",
        "keywords": [
            "Ginkgo biloba extract",
            "fix",
            "atrophy",
            "skeletal muscle"
        ],
        "authors": [
            {
                "name": "HUANG Zhi",
                "org": "Department of Orthopaedics & Traumatology,Chinese PLA 187th Hospital,Haikou,Hannan ,China,"
            },
            {
                "name": "YU Bin",
                "org": "Department of Orthopaedics,Nanfang Hospital,Nanfang Medical University,Guangzhou ,China,"
            },
            {
                "name": "YUN Xiong",
                "org": "Department of Orthopaedics & Traumatology,Chinese PLA 187th Hospital,Haikou,Hannan ,China,"
            },
            {
                "name": "ZHU Jie",
                "org": "Department of Hand Surgery,Chinese PLA 153rd Hospital,Zhengzhou ,China"
            },
            {
                "name": "HU Yan-Jun",
                "org": "Department of Orthopaedics,Nanfang Hospital,Nanfang Medical University,Guangzhou ,China,"
            }
        ],
        "venue": "Journal of the Fourth Military Medical University",
        "year": 2008
    },
    "EydSTT7E": {
        "id": "EydSTT7E",
        "title": "Aucubin prevents interleukin-1 beta induced inflammation and cartilage matrix degradation via inhibition of NF-κB signaling pathway in rat articular chondrocytes.",
        "abstract": "Proinflammatory cytokine interleukin-1β (IL-1β) plays a crucial role in the pathogenesis of Osteoarthritis (OA) by stimulating several mediators contributed to cartilage degradation. Aucubin, a natural compound derived from plants which has been shown to possess diverse biological activities including anti-inflammatory property, may benefit the IL-1β stimulated chondrocytes. The present study was aimed to investigate the effects of Aucubin on IL-1β stimulated rat chondrocytes. Rat chondrocytes were cultured and pretreated with Aucubin (1, 10, 20, 50μM), and then stimulated with or without IL-1β (10ng/ml). Gene and protein expression of MMP-3, MMP-9, MMP-13, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) was determined by real-time PCR and Western blotting respectively. Nitric oxide (NO) production was quantified by Griess reagent. Phosphorylation and nuclear translocation of p65 were detected by western blotting and immunofluorescence, respectively. We found that Aucubin significantly reversed the elevated gene and protein expression of MMP-3, MMP-9, MMP-13, iNOS, COX-2 and the production of NO induced by IL-1β challenge in rat chondrocytes. Furthermore, Aucubin was able to suppress the IL-1β-mediated phosphorylation and nuclear translocation of p65, indicating Aucubin may possibly act via the NF-κB signaling pathway. The present study proposes that Aucubin may be a potential therapeutic choice in the treatment of OA due to its anti-inflammatory and chondroprotective features.",
        "keywords": [
            "Aucubin",
            "Chondrocyte",
            "IL-1β",
            "MMPs",
            "Osteoarthritis"
        ],
        "authors": [
            {
                "name": "Sheng-Nan Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Guo-Ping Xie",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Cheng-He Qin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Yi-Rong Chen",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Kai-Rui Zhang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Xue Li",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Qian Wu",
                "org": "Department of spinal surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Wei-Qiang Dong",
                "org": "Department of Orthopaedics, The First Affiliated Hospital to Guangzhou Medical University, Guangzhou 510120, China."
            },
            {
                "name": "Jun Yang",
                "org": "Department of Orthopaedics, 421 Hospital of People's Liberation Army, Guangzhou 510318, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            }
        ],
        "venue": "International immunopharmacology",
        "year": 2015
    },
    "gcinqKrQ": {
        "id": "gcinqKrQ",
        "title": "Establishment of digital instrumental library and operative simulation of Scandinavian total ankle replacement",
        "abstract": "[Objective]To investigate the feasibility and method of establishing digital analogical Scandinavian total ankle replacement. [Methods]3D models of ankle,frequently used surgical instruments and joint prosthesis were established through the softwares of Mimics 10.01,Geomagic studio 10.0 and PRO/E 2.0,then operating procedures of Scandinavian total ankle replacement were gradually simulated through the software of PRO/E 2.0.[Results]Operating procedures of Scandinavian total ankle replacement have been successfully simulated.[Conclusion]Estalishment of digital analogical Scandinavian total ankle replacement is feasible.It is beneficial to know and mast the surgical operation,and guide the preoperative preparation and procedures at operation.",
        "keywords": [
            "operative simulation",
            "Scandinavian total ankle replacement",
            "total ankle replacement"
        ],
        "authors": [
            {
                "name": "XU Hong-zhang",
                "org": ".Department of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ".Department of Orthopaedic Trauma,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2011
    },
    "3Pz6yOAx": {
        "id": "3Pz6yOAx",
        "title": "Proximal femoral nail vs. dynamic hip screw in treatment of intertrochanteric fractures: a meta-analysis.",
        "abstract": "The aim of this meta-analysis was to compare the outcomes of proximal femoral nail (PFN) and dynamic hip screw (DHS) in treatment of intertrochanteric fractures.Relevant randomized or quasi-randomized controlled studies comparing the effects of PFN and DHS were searched for following the requirements of the Cochrane Library Handbook. Six eligible studies involving 669 fractures were included. Their methodological quality was assessed and data were extracted independently for meta-analysis.The results showed that the PFN group had significantly less operative time (WMD: -21.15, 95% CI: -34.91 - -7.39, P=0.003), intraoperative blood loss (WMD: -139.81, 95% CI: -210.39 - -69.22, P=0.0001), and length of incision (WMD: -6.97, 95% CI: -9.19 - -4.74, P<0.00001) than the DHS group. No significant differences were found between the 2 groups regarding postoperative infection rate, lag screw cut-out rate, or reoperation rate.The current evidence indicates that PFN may be a better choice than DHS in the treatment of intertrochanteric fractures.",
        "keywords": [],
        "authors": [
            {
                "name": "Kairui Zhang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Sheng Zhang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Jun Yang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Weiqiang Dong",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Shengnan Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Yirong Cheng",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Mohammed Al-Qwbani",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            },
            {
                "name": "Qiang Wang",
                "org": "Department of Orthopaedics, Subei People's Hospital of Jiangsu Province (Clinical Medical College of Yangzhou University), Yangzhou, China (mainland)."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China (mainland)."
            }
        ],
        "venue": "Medical science monitor : international medical journal of experimental and clinical research",
        "year": 2014
    },
    "9zFP4EtP": {
        "id": "9zFP4EtP",
        "title": "Effects of hepatocyte growth factors on contractile function of disused gastrocnemius atrophy in rats",
        "abstract": "Objective To explore the possible effects of hepatocyte growth factors (HGF) on prevention and therapy of disused gastrocnemius atrophy in rats by observing their effects on the wet weight and contractile function of the gastrocnemius of fixed hind limbs. Methods Twenty-four Wister male rats were randomly divided into a blank group, a contrast group and an experimental group. Their right hind limbs were fixed for four weeks with plastic piaster from metatarsus to 1 cm up the knee. Their knee joint was fixed in 100°flexion and their ankle joint in 60°plantar flexion. Rats in the contrast group were injected with 0. 2 mL of normal saline, and rats in the ex- perimental group were injected with HGF (10 mg/kg, 10 mg/mL). Their whole gastrocnemius of the right hind limb was dissected four weeks later to measure its contractile function and wet weight. Results Compared with the blank group, single maximal contraction, maximal tetanus, and wet weight of the gastrocnemius in the contrast and experimental groups decreased significantly (P＜0. 05), and fields of electric stimulation also decreased signifi- cantly (P＜0. 05). Compared with the contrast group, single maximal contraction, maximal tetanus, and wet weight of the gastrocnemius in the experimental group were significantly superior (P＜0.05), and fields of electric stimulation significantly increased. Conclusion Since after a local injection of HGF, the contractile function and wet weight can be significantly increased, HGF may have a preventive effect on disused atrophy.",
        "keywords": [
            "Hepatocyte growth factor(HGF)",
            "Contractile function",
            "Atrophy",
            "Wet weight"
        ],
        "authors": [
            {
                "name": "HUANG Yan",
                "org": "ang. Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "ang. Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "WANG D",
                "org": "ang. Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Orthopaedic Trauma",
        "year": 2006
    },
    "ararQWx5": {
        "id": "ararQWx5",
        "title": "Scaffold composed of porous vancomycin-loaded poly(lactide-co-glycolide) microspheres: A controlled-release drug delivery system with shape-memory effect.",
        "abstract": "Loading antibiotics in a biodegradable polymer matrix is an excellent way to control its release kinetics, which eliminates side effects caused conventional administrations of the drug. This approach is especially beneficial for bone regeneration when using a scaffold made of a biodegradable polymer loaded with drug agents capable of controllable releases. In this case, the scaffold serves as a mechanical support to tissue formation and the drug agents may provide biomolecules to assist the tissue formation and/or provide antibiotics to prevent tissues from infections. Towards this goal, we have developed an approach to make vancomycin-loaded poly(lactide-co-glycolide) (PLGA) microspheres, from which we made scaffolds by compression molding. In this article we concentrate on characterizing the porosity and drug release profiles, as well as verifying shape-memory effect of the scaffolds. The scaffold was biodegradable and showed a much slower drug release profile than micro spheres. We confirmed that our PLGA scaffolds recovered to their permanent shapes when heated to 45 degrees C. We believe that these scaffolds will find applications in bone regeneration where both the use of antibiotics against infection and accommodation to spatial restrictions may be required. (C) 2017 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Antibiotics Biodegradability",
            "Vancomycin-loaded poly(lactide-co-glycolide)",
            "microspheres",
            "Scaffold",
            "Controlled-release drug delivery",
            "Shape-memory effect"
        ],
        "authors": [
            {
                "name": "Lin Du",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Shenyu Yang",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Wenqiang Li",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Haoying Li",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Shanbao Feng",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Rong Zeng",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Liangxing Xiao",
                "org": "Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Heng-Yong Nie",
                "org": "Univ Western Ontario, Surface Sci Western, 999 Collip Circle, London, ON N6G 0J3, Canada"
            },
            {
                "name": "Mei Tu",
                "org": "Jinan Univ, Dept Mat Sci & Technol, Guangzhou 510632, Guangdong, Peoples R China"
            }
        ],
        "venue": "MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS",
        "year": 2017
    },
    "HjkFbRVr": {
        "id": "HjkFbRVr",
        "title": "Reply to comment on Gong et al.: Single-bundle versus double-bundle anterior cruciate ligament reconstruction: an up-to-date meta-analysis.",
        "abstract": "",
        "keywords": [
            "Anterior Cruciate Ligament",
            " Anterior Cruciate Ligament Reconstruction",
            " Cruciate Ligament",
            " Ligament Reconstruction",
            " International Knee Documentation Committee"
        ],
        "authors": [
            {
                "name": "Xue Li",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, No.1838, Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Chang-peng Xu",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Jin-qi Song",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            }
        ],
        "venue": "International orthopaedics",
        "year": 2013
    },
    "B41ZCO16": {
        "id": "B41ZCO16",
        "title": "Preparation of calcium phosphate cement and polymethyl methacrylate for biological composite bone cements.",
        "abstract": "We studied the biological safety, biomechanics, and tissue compatibility of calcium phosphate cement and Polymethyl Methacrylate composite bone cement mixed in different ratios.CPC and PMMA were mixed in different ratios (3:1, 2:1, 1:1, 1:2, 1:5, 1:10, 1:15, and 1:20). PMMA solvent is a general solvent containing a dissolved preparation of the composite bone cement specific to a given specimen to determine biological safety, biomechanics, and tissue compatibility.The CPC/PMMA (33%) group, CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group were more in line with the composite bone cement without cytotoxicity requirements. The compressive strength of the CPC/PMMA (67%) group and CPC/PMMA (75%) group was 20 Mpa-30 Mpa, while that of the CPC/PMMA (4.8%) group, CPC/PMMA (6.25%) group, CPC/PMMA (9.1%) group, CPC/PMMA (16.7%) group, CPC/PMMA (33%) group, and CPC/PMMA (50%) group was 40 Mpa-70 Mpa. Curing time was longer in the CPC group (more than 11 min) and shorter in the PMMA group (less than 2 min). The results of weight loss rate showed that there were no significant differences between the CPC/PMMA group (4.8%, 6.25%, 9.1%, 16.7%, 33%) and PMMA control group (p>0.05). With the decrease of CPC content, the rate of weight loss gradually decreased.The CPC/PMMA (50%) group, CPC/PMMA (67%) group, and CPC/PMMA (75%) group provide greater variability and selectivity for the composite bone cement in obtaining better application.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Jun",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Zhang Kairui",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Zhang Sheng",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Fan Jiping",
                "org": "Department of Orthopaedics, 421 hospital of PLA, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Guo Xinhui",
                "org": "Department of Orthopaedics, 421 Hospital of PLA, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Dong Weiqiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Wang Shengnan",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Chen Yirong",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            },
            {
                "name": "Yu Bin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China (mainland)."
            }
        ],
        "venue": "Medical science monitor : international medical journal of experimental and clinical research",
        "year": 2015
    },
    "JOw8yvzE": {
        "id": "JOw8yvzE",
        "title": "Application of computer-aided osteotomy template design in treatment of developmental dysplasia of the hip with steel osteotomy]",
        "abstract": "To provide an accurate method for osteotomy in the treatment of developmental dysplasia of the hip with steel osteotomy by three-dimensional reconstruction and Reverse Engineering technique.Between January 2011 and December 2012, 13 children with developmental dysplasia of the hip underwent steel osteotomy. 3D CT scan pelvic images were obtained and transferred via a DICOM network into a computer workstation to construct 3D models of the hip using Materialise Mimics 14.1 software in STL format. These models were imported into Imageware 12.0 software for steel osteotomy simulation until a stable hip was attained in the anatomical position for dislocation or subluxation of the hip in older children. The osteotomy navigational templates were designed according to the anatomical features after a stable hip was reconstructed. These navigational templates were manufactured using a rapid prototyping technique.The reconstruction hips in these children show good matching property and acetabulum cover.The computer-aided design of osteotomy template provides personalized and accurate solutions in the treatment of developmental dysplasia of the hip with steel osteotomy in older children.",
        "keywords": [
            "three-dimensional reconstruction",
            "digital technology",
            "hip",
            "reverse engineering",
            "developmental dysplasia",
            "osteotomy template",
            "computer-aided design"
        ],
        "authors": [
            {
                "name": "Kuang Tong",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Yuanzhi Zhang",
                "org": "Center for Digital Medicine/Department of Othorpedics of Affiliated Hospital,Inner Mongolia Medical university,Hohhot ,China"
            },
            {
                "name": "Sheng Zhang",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2013
    },
    "2qfzOHH8": {
        "id": "2qfzOHH8",
        "title": "Should displaced midshaft clavicular fractures be treated surgically? A meta-analysis based on current evidence.",
        "abstract": "This study was designed to compare clinical effectiveness of operative with nonoperative treatment for displaced midshaft clavicular fractures (DMCF).We systematically searched electronic databases (MEDILINE, EMBASE, CLINICAL, OVID, BIOSIS and Cochrane registry of controlled clinical trials) to identify randomized controlled trials (RCTs) in which operative treatment was compared with nonoperative treatment for DMCF from 1980 to 2012. The methodologic quality of trials was assessed. Data from chosen studies were pooled with using of fixed-effects and random-effects models with mean differences and risk ratios for continuous and dichotomous variables, respectively.Four RCTs with a total of 321 patients were screened for the present study. Results showed that the operative treatment was superior to the nonoperative treatment regarding the rate of nonunion [95 % confidence interval (CI) (0.05, 0.43), P = 0.0004], malunion [95 % CI (0.06, 0.34), P < 0.00001] and overall complication [95 % CI (0.43-0.76), P = 0.0001]. Subgroup analyses of complications revealed that significant differences were existed in the incidence of neurologic symptoms [95 % CI (0.20, 0.74), P = 0.004] and dissatisfaction with appearance [95 % CI (0.19, 0.65), P = 0.001]. Lack of consistent and standardized assessment data, insufficiency analysis that carried out showed improved functional outcomes (P < 0.05) in operative treatment.The available evidence suggests that the operative treatment for DMCF is associated with a lower rate of nonunion, malunion and complication than nonoperative treatment. This study supports traditional primary operative treatment for DMCF in active adults.",
        "keywords": [
            "Meta-analysis",
            " Operative treatment",
            " Nonoperative treatment",
            " Displaced midshaft clavicular fractures"
        ],
        "authors": [
            {
                "name": "Chang-peng Xu",
                "org": "Orthopaedics and Trauma, NanFang Hospital, Southern Medical University, No. 1838 Guangzhou Da Dao Bei, Guangzhou, Guangdong Province 510515, China."
            },
            {
                "name": "Xue Li",
                "org": "Orthopaedics and Trauma, NanFang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Zhuang Cui",
                "org": "Orthopaedics and Trauma, NanFang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Xi-cai Diao",
                "org": "Orthopaedics and Trauma, NanFang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Orthopaedics and Trauma, NanFang Hospital,Southern Medical University,Guangzhou,China"
            }
        ],
        "venue": "European journal of orthopaedic surgery & traumatology : orthopédie traumatologie",
        "year": 2013
    },
    "UWoht0rr": {
        "id": "UWoht0rr",
        "title": "Finite element analysis of intertrochanteric fracture fixed with dynamic hip screw and percutaneous compression plate",
        "abstract": "[Objective]To explore the biomechanical properties of intertrochanteric fracture fixed with dynamic hip screw and percutaneous compression plate(PCCP) through finite element(FE) analysis,and therefore to provide scientific foundation for clinic application.[Method]3D FE model of the Evans-JensenⅡintertrochanteric fracture with different fixations was developed.The different fixations were compared for von Mises distribution,and the von Mises distribution of the femur and the fracture surface contact pressure were also compared.[Result]Finite element simulation showed that the von Mises distribution with PCCP was more even,and the principal stress was lower.The von Mises distribution of the femur fixed with PCCP was even.The fracture surface contact pressure was higher and more evenly in the fracture fixed with PCCP.[Conclusion]The fracture fixed with PCCP exhibites fine fixation stability for Evans-JensenⅡintertrochanteric fracture.",
        "keywords": [
            "finite element analysis",
            "percutaneous compression plate",
            "dynamic hip screw",
            "intertrochanteric fracture"
        ],
        "authors": [
            {
                "name": "ZHANG Kai-rui",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "DAI Hai-fei",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2012
    },
    "zcm9fjAM": {
        "id": "zcm9fjAM",
        "title": "Three-dimensional finite element analysis of ankle arthrodesis with fibular strut graft",
        "abstract": "BACKGROUND:Finite element modeling in biomechanical experiment has advantages in shorter experiment time,lower expense,simulation of complex boundary condition,full analysis of biomechanical characteristics and repeatability.OBJECTIVE:To establish a finite element model of ankle arthrodesis with fibular strut graft,to evaluate the biomechanical stability and safety,and to study the biomechanical characteristics of ankle arthrodesis with fibular strut graft.METHODS:A three-dimensional model of a healthy ankle was developed from computed tomography images.Ankle arthrodesis was simulated by Abaqus 6.9 software,and the model was submitted to mechanical analysis under four load procedures according to the postoperative activity pattern of ankle(neutral position,dorsiflexion,external rotation and internal rotation).RESULTS AND CONCLUSION:The model was successful established and had high geometric similarity.In dorsiflexion status,posterior-anterior screw yielded maximum stress concentration at middle part;meanwhile,maximum displacement occurred at the fusion site.Screw stress at posterolateral tibial was maximal.A high concentrated stress was found surrounding the screw hole.High stress was distributed between the screw holes of fibular strut.To avoid the high concentration of stress distribution,the crossed screws should be configured appropriately.And additional ante-dorsiflexion immobilization might lower the risk of screw implant failure.Shortening of distance between parallel screws and centralized drilling on fibula also tended to reduce the risk of strut failure.",
        "keywords": [],
        "authors": [
            {
                "name": "Ouyang Han-bin",
                "org": " Department of Orthopedic Trauma,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Xiong Jun",
                "org": " Department of Orthopedic Trauma,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Xiang Peng",
                "org": " Department of Orthopedic Trauma,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Cui Zhuang",
                "org": " Department of Orthopedic Trauma,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Chen Li-guang",
                "org": " Department of Orthopedic Trauma,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Yu Bin",
                "org": " Department of Orthopedic Trauma,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            }
        ],
        "venue": "Chinese Journal of Tissue Engineering Research",
        "year": 2012
    },
    "GYCOh7Hd": {
        "id": "GYCOh7Hd",
        "title": "Letter to the editor: Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial.",
        "abstract": "",
        "keywords": [
            "vitamin d"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, No.1838, Guangzhou Ave. North, Guangzhou, 510515, P.R. China."
            },
            {
                "name": "Yan-jun Hu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Clinical orthopaedics and related research",
        "year": 2013
    },
    "cOgZLQaE": {
        "id": "cOgZLQaE",
        "title": "Health-related quality of life after treatment for malignant bone tumors: a follow-up study in China.",
        "abstract": "We conducted the present study to assess health-related quality of life (HRQoL) among bone cancer patients after surgical treatment in one large teaching hospitals in China, and assess the risk factors for improving the physical or mental HRQoL.344 eligible adult patients who were admitted to the hospital with malignant bone tumors during the period of Jun. 2008 to Dec. 2011, and a reference group with 361 health cases was recruited in the same hospital during the same period. All 344 patients were followed up for one year. The HRQoL before treatment and after one year was evaluated with the Medical Outcome Short Form 36 (SF-36).All 8 domains of HRQoL had the lowest scores greatly improved over the first year after discharge. However, the patients still had significantly lower scores in every domain than the reference group one year after discharge. Age and type of surgery were associated with HRQoL in the mental domain.The HRQoL of patients with malignant bone tumors greatly improved one year after the treatment. This study also highlighted the utility of HRQoL assessment for prognostic evaluation of patients after surgical treatment for bone cancer.",
        "keywords": [
            "follow-up",
            "health-related quality of life",
            "malignant bone tumors",
            "sf-36"
        ],
        "authors": [
            {
                "name": "Yong-Jian Sun",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yan-Jun Hu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Dan Jin",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jian-Wei Li",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 2012
    },
    "uaDV8wGP": {
        "id": "uaDV8wGP",
        "title": "Effect of treadmill exercise timing on repair of full-thickness defects of articular cartilage by bone-derived mesenchymal stem cells: an experimental investigation in rats.",
        "abstract": "Current medical practice for the treatment of articular cartilage lesions remains a clinical challenge due to the limited self-repair ability of articular cartilage. Both experimental and clinical researches show that moderate exercise can improve articular cartilage repair process. However, optimal timing of moderate exercise is unclear. We aimed to evaluate the effect of timing of moderate treadmill exercise on repair of full-thickness defects of articular cartilage.Full-thickness cartilage defects were drilled in the patellar groove of bilateral femoral condyles in a total of 40 male SD rats before they were randomly assigned into four even groups. In sedentary control (SED) group, no exercise was given; in 2-week (2W), 4-week (4W) and 8-week groups, moderate treadmill exercise was initiated respectively two, four and eight weeks after operation. Half of the animals were sacrificed at week 10 after operation and half at week 14 after operation. Femoral condyles were harvested for gross observation and histochemical measurement by O'Driscoll scoring system. Collagen type II was detected by immunohistochemistry and mRNA expressions of aggrecan and collagen type II cartilage by RT-PCR.Both 10 and 14 weeks post-operation, the best results were observed in 4W group and the worst results appeared in 2W group. The histochemistry scores and the expressions of collagen type II and aggrecan were significantly higher in 4W group than that in other three groups (P<0.05).Moderate exercise at a selected timing (approximately 4 weeks) after injury can significantly promote the healing of cartilage defects but may hamper the repair process if performed too early while delayed intervention by moderate exercise may reduce its benefits in repair of the defects.",
        "keywords": [
            "mesenchymal stromal cells",
            "analysis of variance",
            "immunohistochemistry",
            "dna primers"
        ],
        "authors": [
            {
                "name": "Jin-qi Song",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            },
            {
                "name": "Fu Dong",
                "org": "Department of Orthopaedics, Beihai People's Hospital of Guangxi Province, Bei Hai, Guangxi Province, China."
            },
            {
                "name": "Xue Li",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            },
            {
                "name": "Chang-peng Xu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            },
            {
                "name": "Zhuang Cui",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            },
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            },
            {
                "name": "Jun-jie Jia",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China; Key Laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "ew3F1TYp": {
        "id": "ew3F1TYp",
        "title": "Mini-incision versus standard incision total hip arthroplasty regarding surgical outcomes: a systematic review and meta-analysis of randomized controlled trials.",
        "abstract": "It remains controversial whether mini-incision (MI) benefits patients in total hip arthroplasty (THA). We performed a meta-analysis of randomized controlled trials (RCTs) to assess the effects of MI on surgical and functional outcomes in THA patients.A systematic electronic literature search (up to May 2013) was conducted to identify RCTs comparing MI with standard incision (SI) THA. The primary outcome measures were surgical and functional outcomes. According to the surgical approach taken, MI THA patients were divided into four subgroups for sub-group meta-analysis. Standardized mean differences (SMDs) or risk differences (RDs) with accompanying 95% confidence intervals (CIs) were calculated and pooled using a fixed-effect or random-effect model according to the heterogeneity.A total of 14 RCTs involving THA 1,174 patients met the inclusion criteria. The trials were medium risk of bias. The overall meta-analysis showed MI THA reduced total blood loss (95% CI, -201.83 to -21.18; p=.02) and length of hospital stay ( 95% CI, -0.67 to -0.08; p=.01) with significant heterogeneity. However, subgroup meta-analysis revealed posterior MI THA had perioperative advantages of reduced surgical duration ( 95% CI, -8.45 to -2.67; P<.001), less blood loss ( 95% CI, -107.20 to -1.73; P=.04) and shorter hospital stay ( 95% CI, -0.74 to -0.06; p=.002) with low heterogeneity. There were no significant differences between MI and SI THA groups in term of pain medication dose, functional outcome (HHS), radiological outcome or complications (P>.05, respectively).Although no definite overall conclusion can be arrived at on whether MI THA is superior to SI THA, posterior MI THA clearly result in a significant decrease in surgical duration, blood loss and hospital stay. It seems to be a safe minimally invasive surgical procedure without increasing the risk of component malposition or complications.",
        "keywords": [],
        "authors": [
            {
                "name": "Chang-Peng Xu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xue Li",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jin-Qi Song",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Zhuang Cui",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "gAmzvj2Y": {
        "id": "gAmzvj2Y",
        "title": "Effects of celecoxib on proliferation and tenocytic differentiation of tendon-derived stem cells.",
        "abstract": "NSAIDs are often ingested to reduce the pain and improve regeneration of tendon after tendon injury. Although the effects of NSAIDs in tendon healing have been reported, the data and conclusions are not consistent. Recently, tendon-derived stem cells (TDSCs) have been isolated from tendon tissues and has been suggested involved in tendon repair. Our study aims to determine the effects of COX-2 inhibitor (celecoxib) on the proliferation and tenocytic differentiation of TDSCs. TDSCs were isolated from mice Achilles tendon and exposed to celecoxib. Cell proliferation rate was investigated at various concentrations (0.1, 1, 10 and 100 μg/ml) of celecoxib by using hemocytometer. The mRNA expression of tendon associated transcription factors, tendon associated collagens and tendon associated molecules were determined by reverse transcription-polymerase chain reaction. The protein expression of Collagen I, Collagen III, Scleraxis and Tenomodulin were determined by Western blotting. The results showed that celecoxib has no effects on TDSCs cell proliferation in various concentrations (p>0.05). The levels of most tendon associated transcription factors, tendon associated collagens and tendon associated molecules genes expression were significantly decreased in celecoxib (10 μg/ml) treated group (p<0.05). Collagen I, Collagen III, Scleraxis and Tenomodulin protein expression were also significantly decreased in celecoxib (10 μg/ml) treated group (p<0.05). In conclusion, celecoxib inhibits tenocytic differentiation of tendon-derived stem cells but has no effects on cell proliferation.",
        "keywords": [
            "celecoxib",
            "cell proliferation",
            "tendon-derived stem cells",
            "tenocytic differentiation"
        ],
        "authors": [
            {
                "name": "Kairui Zhang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Sheng Zhang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Qianqian Li",
                "org": "Cancer Research Institute, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Jun Yang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Orthopaedics, 421 Hospital of PLA, Guangzhou 510318, China."
            },
            {
                "name": "Weiqiang Dong",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; Department of Orthopaedics, The First Affiliated Hospital to Guangzhou Medical University, Guangzhou 510120, China."
            },
            {
                "name": "Shengnan Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Yirong Cheng",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Mohammed Al-Qwbani",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            },
            {
                "name": "Qiang Wang",
                "org": "Department of Orthopaedics, Subei People's Hospital of Jiangsu Province (Clinical Medical College of Yangzhou University), Yangzhou, Jiangsu Province 225001, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China."
            }
        ],
        "venue": "Biochemical and biophysical research communications",
        "year": 2014
    },
    "auWynUlv": {
        "id": "auWynUlv",
        "title": "High cholesterol inhibits tendon-related gene expressions in tendon-derived stem cells through reactive oxygen species-activated nuclear factor-κB signaling.",
        "abstract": "Clinical studies have indicated that increased serum cholesterol levels raised the risk of tendinopathy in hypercholesterolemia, but the effect of cholesterol on tendon-derived stem cells (TDSCs) and its underlying mechanism have not been studied. The purpose of this study is to investigate the association between cholesterol and tendinopathy in vitro and in vivo, and its underlying molecular mechanism as well. In TDSCs, the effect of cholesterol was assessed by quantitative polymerase chain reaction, western blot analysis, and immunofluorescence staining. Intracellular levels of reactive oxygen species (ROS) was detected, using flow cytometry. The link between nuclear factor (NF)-κB signaling and the effect of cholesterol was evaluated using a representative IκB kinase (IKK) inhibitor, BAY 11-7082. In addition, Achilles tendons from apolipoprotein E mice fed with a high-fat diet were histologically assessed using hematoxylin and eosin staining and immunohistochemistry. We found that high cholesterol apparently lowered the expression of tendon cell markers (collagen 1, scleraxis, tenomodulin), and elevated ROS levels via the NF-κB pathway both in vitro and in vivo. The ROS scavenger N-acetylcysteine (NAC) and BAY 11-7082 reversed the inhibiting effect of cholesterol on the tendon-related gene expressions of TDSCs. Moreover, NAC blocked cholesterol-induced phosphorylation of IκBα and p65. Significant histological alternation in vivo was shown in Achilles tendon in the hypercholesterolemic group. These results indicated that high cholesterol may inhibit the tendon-related gene expressions in TDSCs via ROS-activated NF-кB signaling, implying pathogenesis of tendinopathy in hypercholesterolemia and suggesting a new mechanism underlying hypercholesterolemia-induced tendinopathy.",
        "keywords": [
            "NF-κB pathway",
            "ROS",
            "cholesterol",
            "tendinopathy",
            "tendon-derived stem cells"
        ],
        "authors": [
            {
                "name": "Kaiqun Li",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Ganming Deng",
                "org": "Department of Bone and Joint Surgery, Baoan District People's Hospital of Shenzhen, Shenzhen, China."
            },
            {
                "name": "Ye Deng",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Siwei Chen",
                "org": "Department of Orthopaedics and Traumatology, Changhai Hospital of Shanghai, The Second Military Medical University, Shanghai, China."
            },
            {
                "name": "Hangtian Wu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Caiyu Cheng",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Xianrong Zhang",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Bin Yu",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Kairui Zhang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            }
        ],
        "venue": "Journal of cellular physiology",
        "year": 2019
    },
    "1Zl50Swr": {
        "id": "1Zl50Swr",
        "title": "Efficacy and safety of single-dose local infiltration of analgesia in total knee arthroplasty: a meta-analysis of randomized controlled trials.",
        "abstract": "To examine the efficacy and safety of single-dose local infiltration of analgesia (LIA) for post-operative pain relief in total knee arthroplasty (TKA) patients.A systematic electronic literature search (up to Aug 2013) was conducted to identify the RCTs that address the efficacy and safety of single-dose LIA in the pain management after TKA. Subgroup analysis was conducted to determine changes of visual analog score (VAS) values at six different postoperative time points. Weighted mean differences or relative risks with accompanying 95% confidence intervals were calculated and pooled using a random effect model.Eighteen trials involving 1858 TKA patients met the inclusion criteria. The trials were liable to medium risk of bias. The VAS values at postoperative 2h, 4h, 6h, 12h, 24h, and 48h per patient were significantly lower in the LIA group than in the placebo group, and the former group also had less morphine consumption and better early functional recovery including range of motion, time to straight leg raise and 90° knee flexion than the latter group. No significant difference in length of hospital stay or side effects was detected between the two groups.The current evidence shows that the use of single-dose LIA is effective for postoperative pain management in TKA patients, with satisfactory short-term safety. More high-quality RCTs with long-term follow-ups are required for examining the long-term safety of single-dose LIA.I, II.",
        "keywords": [
            "efficacy",
            "local infiltration",
            "meta-analysis",
            "safety",
            "total knee arthroplasty",
            "meta analysis"
        ],
        "authors": [
            {
                "name": "Chang-Peng Xu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Xue Li",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Zhi-Zhong Wang",
                "org": "Department of Orthopaedics and Traumatology, People's Hospital of Sanshui District of Foshan, Foshan, Guangdong, People's Republic of China."
            },
            {
                "name": "Jin-Qi Song",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            }
        ],
        "venue": "The Knee",
        "year": 2014
    },
    "20COEXBJ": {
        "id": "20COEXBJ",
        "title": "Single-bundle versus double-bundle anterior cruciate ligament reconstruction: an up-to-date meta-analysis.",
        "abstract": "The aim of this meta-analysis was to compare the results of arthroscopic single-bundle and double-bundle anterior cruciate ligament (ACL) reconstruction.We systematically searched electronic databases to identify randomised controlled trials (RCTs) in which arthroscopic single-bundle was compared with double-bundle for ACL reconstruction. The search strategy followed the requirements of the Cochrane Library Handbook. The outcomes of these studies were analysed in terms of graft failures, Lysholm score, negative pivot-shift test, KT1000 arthrometer measurements, knee extensor and flexor peak torques, knee extension and flexion deficit, and subjective and objective International Knee Documentation Committee (IKDC) final score. Methodological quality was assessed and data were extracted independently. Standard mean difference (SMD) or odds ratio (OR) with 95 % confidence interval (CI) was calculated by a fixed effects or random effects model. Heterogeneity across the studies was assessed with the I-square and chi-square statistic. Forest plots were also generated.We identified 17 RCTs comprising 1,381 patients who were treated by arthroscopic single-bundle versus double-bundle ACL reconstruction. The results of meta-analysis of these studies showed that arthroscopic double-bundle reconstruction was associated with a lower risk of graft failures (P=0.002) and a lower rate of positive pivot-shift test (P<0.0001). Compared with single-bundle reconstruction, double-bundle reconstruction had a lower KT1000 arthrometer measurement (P<0.00001), a lower knee extension deficit (P=0.006) and a higher subjective IKDC score (P=0.03). There was no statistically significant difference between single-bundle and double-bundle reconstruction in Lysholm score (P=0.91), knee extensor peak torques (P=0.97), knee flexor peak torques (P=0.96), knee flexion deficit (P=0.30) and objective IKDC score (P=0.18).Considering the more favourable outcomes of graft failures, knee joint stability and knee joint function in double-bundle reconstruction, we concluded that arthroscopic double-bundle reconstruction should be considered as the primary treatment in ACL reconstruction.",
        "keywords": [
            "Anterior Cruciate Ligament",
            " Anterior Cruciate Ligament Reconstruction",
            " Standard Mean Difference",
            " International Knee Documentation Committee",
            " Lysholm Score"
        ],
        "authors": [
            {
                "name": "Xue Li",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, No.1838, Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Chang-peng Xu",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Jin-qi Song",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            }
        ],
        "venue": "International orthopaedics",
        "year": 2013
    },
    "8ePrgME6": {
        "id": "8ePrgME6",
        "title": "Chondroblastoma of the talus: a case report and literature review.",
        "abstract": "Chondroblastoma is a rare, benign cartilaginous neoplasm that accounts for approximately 1% of all bone tumors, and approximately 4% of all chondroblastomas arise in the talus. Here we report a case of chondroblastoma in the left talus. The 22-year-old male patient presented with a 16-month history of ankle pain. Based on radiological and pathological examination, we diagnosed the patient with chondroblastoma. A posterolateral approach was used to allow access to the lesion. After curettage, the allogenic bone chips were packed into the talar body defect. After 2 years' follow-up, we found no recurrence or metastasis of chondroblastoma, suggesting our surgery procedure was effective.",
        "keywords": [
            "neoplasm",
            "ankle",
            "cartilage",
            "surgery",
            "bone tumor"
        ],
        "authors": [
            {
                "name": "Kairui Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yuan Gao",
                "org": "Liaoning Medical University(Liaoning Medical University,Liaoning Medical College),Jinzhou,China"
            },
            {
                "name": "Haifei Dai",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Sheng Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Gong Li",
                "org": "General Hospital of Chinese People's Armed Police Forces(General Hospital of Chinese People's Armed Police Forces,Armed Police General Hospital),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons",
        "year": 2012
    },
    "dgo3QKUz": {
        "id": "dgo3QKUz",
        "title": "Effect of intra-articular ozone injection on serum and synovial TNF-α, TNFR I, and TNFR II contents in rats with rheumatoid arthritis]",
        "abstract": "To observe the effects of intra-articular ozone injection at different concentrations on the contents of tumor necrosis factor-α (TNF-α), TNF receptor I (TNFR I), and TNFR II in the serum and synovium of rats with rheumatoid arthritis (RA) and explore the therapeutic mechanism of ozone in RA treatment.Forty-eight Wistar rats were randomized into 8 groups, including 5 ozone groups receiving intra-articular injection of 10, 20, 30, 40 or 50 µg/ml ozone, a blank control group, an oxygen group and a RA model group. All the rats, except for those in the blank control group, were subjected to hypodermic injection of bovine collagen II and complete Freunds adjuvant to induce RA. Ozone treatment was administered once weekly for 3 weeks starting at 21 days after the modeling. The swelling and thickness of the hind paws were observed, and the serum and synovial contents of TNF-α, TNFR I, and TNFR II were detected.At the end of treatment, the paw thickness was reduced significantly in rats with 40 µg/ml ozone injection compared with that in the model RA group (P<0.01). The serum contents of TNF-α, TNFR I and TNFR II showed no significant difference between the RA model group, oxygen group and the ozone groups, but their synovial contents showed significant reductions in rats with 40 and 50 µg/ml ozone injection (P<0.01); the synovial TNFR I was significantly higher in 40 µg/ml ozone group than in the model group (P<0.05).Intra-articular injection of 40 µg/ml ozone can attenuate synovitis in rats with RA, the mechanism of which may involve the inhibition of TNF-α and TNFR II activity and enhancement of TNFR I activity in the synovium.",
        "keywords": [
            "ozone",
            "tumor necrosis factor receptors",
            "rheumatoid arthritis",
            "tumor necrosis factor-α"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": " Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Hui-qiang Chen",
                "org": " Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Chang-huai Lu",
                "org": " Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Qing-rong Lin",
                "org": " Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Bo-wei Wang",
                "org": " Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Cheng-he Qin",
                "org": " Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2011
    },
    "idUc1DF7": {
        "id": "idUc1DF7",
        "title": "Effects of hypoxia-combined-exercise on the expression of hypoxia inducible factor in skeletal muscle of rats",
        "abstract": "AIM: To study the effects of hypoxia and hypoxia combined exercise on the expression of hypoxia inducible factor-1 (HIF-1)in gastrocnemius of rats, and explore the significance of exercise in hypoxia adaptation of skeletal muscles. METHODS: The experiment was conducted in Guangzhou College of Physical Education during December 2003. Eighty male SD rats aged 2 months were divided randomly into four groups according to drawing: no-exercise control group, exercise-control group, hypoxia group and hypoxia-combined-exercise group with 20 rats in each group. Hypoxia and hypoxia-combined-exercise models were made. The rats in the hypoxia group and hypoxia-combined-exercise group were put into canvas with decompression for 23 hours every day, and treadmill training was performed for 1 hour within decompression canvas, and the speed of treadmill was set at 25 m per minute. The exercise performed in the exercise-control group was the same to the former two groups. The rats in the hypoxia group were treated with the same training with those in the hypoxia-combined-exercise group except no exercise. All the experimental animals were anesthetized with 30 g/L sodium pentobarbital at the 3rd, 7th, 10th and 14th days after the beginning of experiment in batch (4 rats every time). Gastrocnemius at the left side was cut rapidly and completely. After weighing, 1 g muscle tissue was gained to make muscle slurry for preparing. Changes of contents of HIF in gastrocnemius of rats were detected with Surface-enhanced Laser Desorption/Ionization(SELDI). RESULTS: During the experiment, three rats were excluded because they could not finish the trial. Data of 77 rats were effective, and 4 rats in every group were involved in the result analysis. ① Molecular weight Mr of HIF-1 α protein was 120 167, which indicated that it had post source modification. The expression of HIF-1 α was not found at the 3rd after experiment in the no-exercise control group and hypoxia group. Expression in the exercise-control group was lower than that in the hypoxia-combined-exercise group, and its difference was significant (6.27±1.58),(14.69±1.34),P < 0.001 . ② The expression of HIF-1 α was not found at the 7th after experiment in the no-exercise control group. The expression in the exercise-control group decreased partly. The expression in the hypoxia group could be found. The expression in the hypoxia-combined-exercise group increased. There were significant differences in the hypoxia-combined-exercise group, exercise-control group and hypoxia group (20.13±0.85),(4.81±0.69),(2.27±0.61)P < 0.001. ③ The expression of HIF-1 α was still not found at the 10th after experiment in the no-exercise control group. The expression in the exercise-control group reduced partly. The expression in the hypoxia group could be found. The expression in the hypoxia-combined-exercise group increased. There were significant differences in the hypoxia-combined-exercise group, exercise-control group and hypoxia group (26.23±0.84),(3.76±0.63),(3.65±0.73),P < 0.001. ④ The expression of HIF-1 α was still not found at the 14th after experiment in the no-exercise control group. The expression in the exercise-control group fell down partly. The expression in the hypoxia group could be found. The expression in the hypoxia-combined-exercise group was fortified. There were significant differences in the hypoxia-combined-exercise group, exercise-control group and hypoxia group (29.54±0.61),(1.29±0.35),(13.47±0.62),P < 0.001. ⑤ The content of HIF had interaction with hypoxia degree, time and exercise. Under the hypoxia condition designed by this trial, the longer the hypoxia time, the higher the content in the skeletal muscles of rats that was given suitable exercise at the same time was. CONCLUSION: The hypoxia-combined-exercise can induce the expression of related gene by increasing the expression of HIF, enhance the hypoxia adaptive capacity of skeletal muscles that plays the effect of protecting skeletal muscle.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Department of Orthopedics and Trauma, Affiliated Nanfang Hospital,"
            },
            {
                "name": "Zhi Zhong Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Su Xiu-yun",
                "org": "Department of Orthopedics and Trauma, Affiliated Nanfang Hospital,"
            },
            {
                "name": "Hou Zhen-hai",
                "org": "Department of Orthopedics and Trauma, Affiliated Nanfang Hospital,"
            },
            {
                "name": "Zhong Shi-zhen",
                "org": "Staff Room of Dissection, Southern Medical University, Guangzhou , Guangdong Province, China"
            }
        ],
        "venue": "Chinese Journal of Clinical Rehabilitation",
        "year": 2005
    },
    "7zn2hNrf": {
        "id": "7zn2hNrf",
        "title": "Percutaneous Compression Plate(PCP) Versus Dynamic Hip Screw(DHS) for Intertrochanteric Fractures:A Meta-analysis",
        "abstract": "Objective To determine the effect of Percutaneous compression plate(PCP) versus Dynamic hip screw(DHS) for intertrochanteric fractures.Methods MEDLINE(1966-December,2010),PUBMED(1974～December,2010) and CBM disc(1979-December,2010),and the relevant Chinese and English orthopedic journals were searched retrospectively.Randomized controlled trials(RCTs) and controlled clinical trials(CCTs) of PCP versus DHS for Intertrochanteric fractures were included.The system review was performed with the method recommended by the Cochrane Collaboration.Results Four studies(3 RCTs and 1 CCTs) were included,involving 557 patients(246 PCP cases and 311 DHS cases).The results of meta analysis showed there were no significant differences in operating time(WMD=-10.96,95% CI-26.47～4.56,P=0.17),post-operative infection rate(RR=0.43,95% CI 0.55～1.28,P=0.13),post-operative mortality rate(≤1 year)(RR=0.88,95% CI 0.55～1.40,P=0.58),or in the length of stay in hospital(WMD=-0.77,95% CI-2.09～1.94,P=0.94).Conclusion Compared with DHS,PCP have no advantages in operating time,post-operative infections,post-operative mortality(≤1 year),or the length of stay in hospital for intertrochanteric fractures.",
        "keywords": [
            "meta-analysis",
            "bone plate",
            "bone screw",
            "hip fractures"
        ],
        "authors": [
            {
                "name": "CHEN Yi-rong",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "ZHANG Kai-rui",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Practical Orthopaedics",
        "year": 2011
    },
    "75YJvvFt": {
        "id": "75YJvvFt",
        "title": "Health Care Costs of Post-traumatic Osteomyelitis in China: Current Situation and Influencing Factors.",
        "abstract": "An unexpectedly large proportion of the direct health care costs for inpatients with extremity post-traumatic OM went to cover an external fixator, with expenses for pharmaceuticals and treatment accounting for only a little more than the tenth of the total health care costs. Use of external fixator, external fixator type, infection site, and infection-associated injury type directly influenced the health care costs.",
        "keywords": [
            "Economic burden",
            "External fixator",
            "Health care cost",
            "Influencing factors",
            "Post-traumatic osteomyelitis",
            "Retrospective analysis"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China."
            },
            {
                "name": "Hang-Tian Wu",
                "org": "Guangdong Provincial Key Laboratory of Bone & Cartilage Regenerative Medicine, Southern Medical University, Guangzhou, P.R. China."
            },
            {
                "name": "Qing-Rong Lin",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China."
            },
            {
                "name": "Yan-Jun Hu",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China; Guangdong Provincial Key Laboratory of Bone & Cartilage Regenerative Medicine, Southern Medical University, Guangzhou, P.R. China. Electronic address: smuyubin@163.com."
            }
        ],
        "venue": "The Journal of surgical research",
        "year": 2019
    },
    "QdSOXLKk": {
        "id": "QdSOXLKk",
        "title": "3-Dimensional measurement of resection heights and sex difference in the design of of the distal femoral prosthesis",
        "abstract": "Objective To study the differences in the design of the femoral prosthesis between men and women with 3-dimensional CT.Methods 80 normal knees of Chinese adults (male 40, female 40, age 18-72 years) were examined by MSCT scanning with 0.625 mm thin gap, three-dimensional reconstruction of the distal femur was performed on Geomagic Studio 3-dimensional imaging system. Then, the width of the femur through the transepicondylar line, the height of the medial condylar, together with the lateral condylar were measured. The distance between anterior processes of the medial and lateral trochleas were calculated by stimulating osteotomy. All the data was grouped and a comparison was preformed by gender.Results The parameters of the male femur were bigger than those of the women, including the width of the femur through the transepicondylar line, the height of the condylars and the anterior process of trochleas(P<0.001). Moreover, there was a significant difference in the ratio of the mediallateral diameter and anteroposterior diameter between genders.Conclusions There were certain anatomy differences in the distal femurs between male and female. Gender difference should be considered in the design of the femoral prosthesis in order to achieve a satisfactory outcome in total knee arthoplasty.",
        "keywords": [
            "replacement",
            "Prosthesis",
            "Femur",
            "knee",
            "Gender identity",
            "Arthroplasty"
        ],
        "authors": [
            {
                "name": "LUO Ji-wei",
                "org": ". Department of Orthopaedics and Traumatology, Nafang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "QIN Cheng-he",
                "org": ". Department of Orthopaedics and Traumatology, Nafang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "HU Yan-jun",
                "org": ". Department of Orthopaedics and Traumatology, Nafang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "JIN Dan",
                "org": ". Department of Orthopaedics and Traumatology, Nafang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "YU Bin",
                "org": ". Department of Orthopaedics and Traumatology, Nafang Hospital, Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Joint Surgery(Electronic Edition)",
        "year": 2009
    },
    "9BHRBYSj": {
        "id": "9BHRBYSj",
        "title": "The role of EGFR signaling in age-related osteoporosis in mice cortical bone.",
        "abstract": "So far, there has been no effective cure for osteoporotic cortical bone, the most significant change in long bone structure during aging and the main cause of bone fragility fractures, because its underlying molecular and cellular mechanisms remain largely unknown. We used 3- and 15-mo-old mice as well as 15-mo-old mice treated with vehicle and gefitinib to evaluate structural, cellular, and molecular changes in cortical bone. We found that the senescence of osteoprogenitors was increased, whereas the expression of phosphorylated epidermal growth factor receptor (EGFR) on the endosteal surface of cortical bone down-regulated in middle-aged 15-mo-old mice compared with young 3-mo-old mice. Further decreasing EGFR signaling by gefitinib treatment in middle-aged mice resulted in promoted senescence of osteoprogenitors and accelerated cortical bone degeneration. Moreover, inhibiting EGFR signaling suppressed the expression of enhancer of zeste homolog 2 (Ezh2), the repressor of cell senescence-inducer genes, through ERK1/2 pathway, thereby promoting senescence in osteoprogenitors. Down-regulated EGFR signaling plays a physiologically significant role during aging by reducing Ezh2 expression, leading to the senescence of osteoprogenitors and the decline in bone formation on the endosteal surface of cortical bone.-Liu, G., Xie, Y., Su, J., Qin, H., Wu, H., Li, K., Yu, B., Zhang, X. The role of EGFR signaling in age-related osteoporosis in mice cortical bone.",
        "keywords": [
            "ERK1/2",
            "Ezh2",
            "aging",
            "degeneration",
            "senescence"
        ],
        "authors": [
            {
                "name": "Guanqiao Liu",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Yongheng Xie",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Jianwen Su",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Hanjun Qin",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Hangtian Wu",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Kaiqun Li",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Bin Yu",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Xianrong Zhang",
                "org": "Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            }
        ],
        "venue": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
        "year": 2019
    },
    "cvmMLq0I": {
        "id": "cvmMLq0I",
        "title": "Effects of ginkgo biloba extract 761 on contraction of gastrocnemius of fixed hindlimb in rats",
        "abstract": "Objective To study the preventive and therapeutic effects of ginkgo biloba extract 761 on disused skeletal muscle atrophy by observing its effects on the wet weight, protein content and contraction of the gastrocnemius of fixed hindlimb in rats. Methods 24 SD rats were divided into blank group, contrast group and experimental group. Their right hind limbs were fixed for 4 weeks with plastic plaster from metatarsus to 1 cm up the knee. The knee joint was fixed in 100° flexion and the ankle joint in 60° plantar flexion. Rats in the contrast group were perfused with 3mL distilled water, and rats in the experimental group were perfused with ginkgo biloba extract 761 (120 mg/kg, 14 mg/mL). The whole gastrocnemius muscle of the right hindlimb was dissected 4 weeks later to measure its contract tension, wet weight and protein content. Results Compared with the blank group, single maximal contraction, maximal tetanus, wet weight and protein content of the gastrocnemius muscle in the contrast and experimental groups decreased significantly (P< 0.05). Compared with the contrast group, single maximal contraction, maximal tetanus, wet weight and protein content of the gastrocnemius muscle in the experimental group were significantly superior (P< 0.05). Conclusion Since Ginkgo biloba extract 761 can improve the quality, contract ability and protein content of muscles of disused atrophy, it has a preventive effect on disused atrophy.",
        "keywords": [
            "Ginkgo biloba extract",
            "Disused atrophy",
            "Contraction",
            "Skeletal muscle",
            "Wet weight"
        ],
        "authors": [
            {
                "name": "HUANG Zhi",
                "org": ", et al. Department of Orthopaedics and Traumatology, Nanfang Hospital, The Southern Medical University, Guangzhou , China"
            },
            {
                "name": "YU Bin",
                "org": ", et al. Department of Orthopaedics and Traumatology, Nanfang Hospital, The Southern Medical University, Guangzhou , China"
            },
            {
                "name": "ZHU Jie",
                "org": ", et al. Department of Orthopaedics and Traumatology, Nanfang Hospital, The Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Orthopaedic Trauma",
        "year": 2005
    },
    "EnFYRBPL": {
        "id": "EnFYRBPL",
        "title": "Celecoxib inhibits the heterotopic ossification in the rat model with Achilles tenotomy.",
        "abstract": "Celecoxib, a selective cox-2 inhibitor, has been shown to prevent the heterotopic ossification following total hip arthroplasty. However, the effects of celecoxib on heterotopic ossification at other locations remain unclear. This study aimed to investigate the effect of celecoxib on heterotopic ossification in the rat model with Achilles tenotomy. Forty male Sprague-Dawley rats, which were randomly divided into 2 groups (n = 20), underwent midpoint Achilles tenotomy on left legs through a posterior approach under aseptic condition. Experimental group was treated with the saline solution of celecoxib (10 mg/kg) per day, while control group was treated by normal saline (0.9%). At 3, 5 and 10 postoperative weeks, all animals were examined by X-ray to assess new bone formation in the Achilles tendon. At 10 weeks after surgery, all animals were killed and Achilles tendons were taken for hematoxylin-eosin (HE) and immunohistochemical staining. Heterotopic ossification developed in 3 rats (15%) in experimental group and 20 rats (100%) in control group by postoperative 10 weeks. The incidence of heterotopic ossification was significantly lower in experimental group than in control group (P < 0.05). Our findings suggest that celecoxib inhibits HO development in rat model with Achilles tenotomy.",
        "keywords": [
            "prostaglandins",
            "cox-2",
            "achilles tenotomy",
            "heterotopic ossification",
            "celecoxib"
        ],
        "authors": [
            {
                "name": "Kairui Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Liang Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Sheng Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Feng Liu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Zhuang Cui",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Dadi Jin",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xiaochun Bai",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "European journal of orthopaedic surgery & traumatology : orthopédie traumatologie",
        "year": 2013
    },
    "jcKx2nER": {
        "id": "jcKx2nER",
        "title": "A retrospective analysis of 140 patients with giant cell tumor in the extremity: a multicenter study based on four hospitals in South China.",
        "abstract": "Update reports are rarely available regarding the bone giant cell tumors (GCTs) in the extremity in Chinese people. The aim of this study was to review the epidemiological characteristics of bone GCT in the extremity based on the clinical data from four hospitals in South China.We searched medical electronic records from January 2001 to December 2011 in four hospitals in South China to identify patients with definite diagnosis of extremity GCT. Epidemiological data including gender, tumor site, age at the time of first diagnosis, local recurrence and pulmonary metastasis were collected and analyzed statistically. Differences between-genders were particularly analyzed regarding first diagnosis age, tumor site, local recurrence and pulmonary metastasis. T-test and Chi-square test were used for continuous and dichotomous variables, respectively.A total of 140 GCT patients (87 males and 53 females) were identified. The gender ratio was 1.64 for a male predominance. GCTs were mostly located around the knee (67 cases). 92 patients were in their 20s to 40s upon first diagnosis. The average age at the time of first diagnosis for all was 30.49 years, 30.76 years for males and 30.06 years for females (P = 0.757). GCT recurred locally in 50 patients (26 males and 24 females) with no gender difference (P = 0.065). The average interval from first surgery to local recurrence was 21.42 months. Pulmonary metastasis was found in 11 patients (8 males and 3 females) also with no gender difference (P = 0.667). The average interval from first diagnosis to metastasis was 36.45 months.Extremity GCT may have a male predominance in Chinese population and mostly occur at 20-40 years of age and around the knee. Follow-ups for GCT patients should be carried on for at least 3 years after primary surgery according to the average intervals for possible local recurrence and pulmonary metastasis.",
        "keywords": [
            "epidemiological characteristics",
            "epidemiology",
            "extremity",
            "giant cell tumor"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Cheng-he Qin",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Cai-xia Tan",
                "org": "Guangzhou University(Guangzhou University ^),Guangzhou,China"
            },
            {
                "name": "Shi-feng Wen",
                "org": "Guangzhou First Municipal People's Hospital(Guangzhou First Municipal People's Hospital,Guangzhou First People's Hospital,First Municipal People's Hospital of Guangzhou),Guangzhou,China"
            },
            {
                "name": "Yun-fei Ma",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Fu Dong",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xi-cai Diao",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Peng Zhang",
                "org": "Zhujiang Hospital(Zhujiang Hospital),Guangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "Cancer epidemiology",
        "year": 2013
    },
    "MQhPQMOk": {
        "id": "MQhPQMOk",
        "title": "A scientific journal should fulfill the multiple social functions",
        "abstract": "This paper explores the multiple social functions that a scientific journal should fulfill.The feasibility of establishing sections to popularize scientific knowledge,report social and cultural messages and make current comments is discussed through practical examples of scientific journals.Analysis is also done on how to construct social functions by a scientific journal.",
        "keywords": [
            "social function",
            "construct",
            "scientific journal"
        ],
        "authors": [
            {
                "name": "ZHANG Ning",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,,Guangzhou,China"
            },
            {
                "name": "LI Guangyu",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,,Guangzhou,China"
            },
            {
                "name": "YU Bin",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,,Guangzhou,China"
            },
            {
                "name": "JIN Dan",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,,Guangzhou,China"
            },
            {
                "name": "NIE Lanying",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,,Guangzhou,China"
            },
            {
                "name": "PEI Guoxian",
                "org": " Editorial Department of Chinese Journal of Orthopaedic Trauma,,Guangzhou,China"
            }
        ],
        "venue": "Acta Editologica",
        "year": 2012
    },
    "43s7x3Q6": {
        "id": "43s7x3Q6",
        "title": "LPHP/PHILOS versus shoulder hemiarthroplasty for the treatment of proximal humeral fractures in adults: a systematic review",
        "abstract": "Background: The therapy of proximal humeral fractures (PHFs) in adults, especially for 3-or 4-part fractures, is still uncertain for traumatology surgeon. Objective: The aim of the study is to systematically review the outcomes of locking proximal humerus plate/proximal humeral internal locking system (LPHP/PHILOS) versus shoulder hemiarthroplasty for the treatment of PHFs in adults. Methods: According to Cochrane systematic review, Cochrane library, Medline, Embase, CNKI, VIP and Chinese Biomedical Database were retrieved for randomized controlled trials (RCTs), Quasi-RCTs and Non-RCTs comparing relevant interventions for the treatment of PHFs with LPHP/PHILOS versus shoulder hemiarthroplasty in adults. Results: Seven Non-RCTs and one Quasi-RCTs were included in this systematic review. For methodology quality, all of them were C-scale trials. There were no significant differences in the excellent and good rates of Neer between LPHP/PHILOS and shoulder hemiarthroplasty (OR=1.27, 95%CI: [0.34, 4.71], P=0.72). Neither were the incidences of complications and secondary operation between the two methods. Conclusions: There are pro and con in the treatment of PHFs by LPHP/PHILOS or shoulder hemiarthroplasty. For the elderly patients of PHFs (75years, 3 or 4-part fractures), most surgeons prefers shoulder hemiarthroplasty. The current literature offers no robust evidence to support LPHP/PHILOS is superior to shoulder hemiarthroplasty for PHFs.",
        "keywords": [
            "shoulder hemiarthroplasty",
            "proximal humeral fractures",
            "locking plate",
            "systematic review"
        ],
        "authors": [
            {
                "name": "Hu Jijie",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Jin Dan",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Wang Gang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Yu Bin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Bone and Joint Surgery",
        "year": 2012
    },
    "pYRunrKp": {
        "id": "pYRunrKp",
        "title": "Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.",
        "abstract": "To identify the effects of running on articular cartilage and subchondral bone remodeling, C57BL/6 mice were randomly divided into three groups: control, moderate-, and strenuous running. Magnetic resonance imaging showed bone marrow lesions in the knee subchondral bone in the strenuous-running group in contrast with the other two groups. The microcomputed tomography analysis showed promoted bone formation in the subchondral bone in mice subjected to strenuous running. Histological and immunohistochemistry results indicated that terminal differentiation of chondrocytes and degeneration of articular cartilage were enhanced but, synthesis of platelet-derived growth factor-AA (PDGF-AA) in the subchondral bone was suppressed after strenuous running. In vitro, excessive mechanical treatments suppressed the expression of PDGF-AA in osteoblasts, and the condition medium from mechanical-treated osteoblasts stimulated maturation and terminal differentiation of chondrocytes. These results indicate that strenuous running suppresses the synthesis of PDGF-AA in subchondral bone, leading to downregulated PDGF/Akt signal in articular cartilage and thus cartilage degeneration.",
        "keywords": [
            "PDGF-AA",
            "cartilage degeneration",
            "osteoarthritis",
            "strenuous running",
            "subchondral bone"
        ],
        "authors": [
            {
                "name": "Zilong Yao",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Peisheng Chen",
                "org": "Department of Orthopedics, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, Fujian, China."
            },
            {
                "name": "Shengnan Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Ganming Deng",
                "org": "Department of Bone and Joint Surgery, Southern Medical University Affiliated Shenzhen Baoan Hospital, Shenzhen, China."
            },
            {
                "name": "Yanjun Hu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Qingrong Lin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Xianrong Zhang",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Bin Yu",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China."
            }
        ],
        "venue": "Journal of cellular physiology",
        "year": 2019
    },
    "SevObIII": {
        "id": "SevObIII",
        "title": "Endoscopic vs. Open Carpal Tunnel Release: Meta-analysis",
        "abstract": "Objective To compare the efficacy and safety of endoscopic carpal tunnel release with open surgery for carpal tunnel syndrome. Methods Based on Cochrane Systematic Review,we searched through the MEDLINE,EMBASE,Cochrane Library and CBM disc,and relevant Chinese and English orthopedic journals by hand,and then collected all the randomized control trials(RCTs) that related to carpal tunnel syndrome.The quality of trials was critically assessed.The Revman4.2.2 that provided by Cochrane Collaboration were used for data management and analysis on the evidence of the difference in the efficacy and safety of endoscopic versus open carpal tunnel(ECTR vs.OCTR) release. Results Totally 8 RCTs were included by total retrieve and riddling.The results of meta-analysis showed no significant differences in the rate of complications,subjective satisfaction,operation time,and hand grip and pinch between groups ECTR and OCTR(P>0.05).The rate of pain and recovery time in group ECTR were lower than that in group OCTR(P<0.05). Conclusions Compared with OCTR,ECTR can reduce the postoperative pain rate and recovery time.There is no significant statistical difference on the rate of complications,subjective satisfaction,operation time,and postoperative hand grip and pinch between the two approaches.However,owing to the study quality and limited sample size,the relationship between the surgical approaches with operation time,and hand grip and pinch needs further studies.",
        "keywords": [
            "Open carpal tunnel release",
            "Carpal tunnel syndrome",
            "Meta-analysis",
            "Endoscopic carpal tunnel release",
            "Systematic review",
            "Randomized control trials"
        ],
        "authors": [
            {
                "name": "Xiong Xiaolong",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Yu Bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Cui Zhuang",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2011
    },
    "eDVStl7L": {
        "id": "eDVStl7L",
        "title": "Bacterial culture experiments of medical ozone",
        "abstract": "Medical ozone therapy has been widely used all over the world, but there are few fundamental studies on whether medical ozone includes bacteria and whether it retains its antibiosis ability in vivo. This study is a bacterial culture experiment of medical ozone at different concentrations (10 μg/ml, 30 μg/ml, 50 μg/ml, 80 μg/ml, using or not a disposable gas filter needle when medical ozone is obtained) from a generator 20 cm upper puff towards culture capsules for 20 minutes in a superclean bench. Sixteen Wistar rats were randomly divided into four groups (n=4). Medical ozone at different concentrations (10 μg/ml, 30 μg/ml, 50 μg/ml, 80 μg/ml) was injected into both knee cavities (0.5ml in each knee cavity) of the rats in the four groups, respectively. A disposable gas filter needle was used when medical ozone was injected into the right side, while it was not used for the left sides for control. Twenty-four hours after injection, douche fluid of the joints was obtained for bacterial culture. All blood agar plates for medical ozone gas directly cultured had no colony. As for the douche fluid culture of the joints, the control group and the fourth experimental group (80 μg/ml) had no colony. The other three groups had one blood agar plate with colonies; and the number of colonies fell as medical ozone concentration increased. Therefore, medical ozone may contain bacteria, and the disinfection of medical ozone after injection may weaken or even disappear, thus in the application of medical ozone therapy a disposable gas filter should be used with the medical ozone generator.",
        "keywords": [
            "Bacterial culture",
            "Medical ozone"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Qingrong Lin",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Ying Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xiaofeng He",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "International Journal of Ozone Therapy",
        "year": 2010
    },
    "P1TLvH2C": {
        "id": "P1TLvH2C",
        "title": "Effect of hepatocyte growth factor on the apoptosis of gastrocnemius cell of fixed hindlimb in rats",
        "abstract": "Objective:To observe the effect of hepatocyte growth factor(HGF) on the apoptosis of gastrocnemius cells of fixed hindlimb in rats.Methods: Animal models were made in rats by Jozsa method.HGF(10 mg/kg) was injected into gastrocnemius of rats in experiment group,and normal saline was injected in control group.The pathological changes and the apoptosis of skeletal muscle cells were observed and recorded.Results: The muscle fibers were good in shape,the shape of bioblast was normal,and new born muscle fibers could be found in the experiment group.TUNEL assay showed that the level of positive expression was higher in the control group than that in the experiment group(P<0.01).The level of positive bcl-2 expression was higher in the experiment group than that in the control group(P<0.01).Conclusion: HGF can obviously decrease the apoptosis of skeletal muscle cells,and it has a preventive effect on disuse atrophy of skeletal muscle.",
        "keywords": [
            "Apoptosis",
            "Disuse atrophy",
            "Skeletal muscle",
            "Hepatocyte growth factor"
        ],
        "authors": [
            {
                "name": "WANG Dong",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,the Southern Medical University,,China"
            },
            {
                "name": "YU Bin",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,the Southern Medical University,,China"
            },
            {
                "name": "ZHU Jie",
                "org": "Department of Orthopaedics and Traumatology,Nanfang Hospital,the Southern Medical University,,China"
            }
        ],
        "venue": "Medical Journal of National Defending Forces in Northwest China",
        "year": 2006
    },
    "cbhNBcKm": {
        "id": "cbhNBcKm",
        "title": "Digital anatomy of the distal femoral fixation with LISS plate",
        "abstract": "Objective To provide a basis on operation of distal femoral fracture by measuring screw canal parameters of distal femoral fixation using digital 3D skill and reverse engineering.Methods 15 adult cases(CT data came from the second affiliated hospital of Inner Mongolia medical college,without knee joint illness,extending from the lower of greater trochanter of femur to the upper 1/3 of tibia,ranging from 18～41 years,averagely 32 years old)were 3D reconstructed,including nail canal digital simulation and fixation.Results For 3D model of distal femur,the canal of screws gradually increased.5 cases were not fit in left and 7 cases in right.Conclusions The screw canal,which is less invasive stable system for distal femur,is regular,with the gradually increased length.The parameters of LISS are differ from anatomic features of Chinese distal femur,and the improvement of LISS is necessary.",
        "keywords": [
            "Distal femur",
            "Digital anatomy",
            "LISS",
            "Anatomical steel"
        ],
        "authors": [
            {
                "name": "HAO Ting",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "HAO Zeng-tao",
                "org": "The second Affiliated Hospital of Inner Mongolia Medical College,Hohhot ,China"
            },
            {
                "name": "FENG Wei",
                "org": "The second Affiliated Hospital of Inner Mongolia Medical College,Hohhot ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Anatomy",
        "year": 2012
    },
    "f4UjPrll": {
        "id": "f4UjPrll",
        "title": "Internal versus external fixation for unstable distal radius fractures: an up-to-date meta-analysis.",
        "abstract": "Our aim was to compare the effect of internal vs external fixation for unstable distal radius fractures regarding postoperative complications, clinical results and radiological outcomes.We selected PubMed; Cochrane Library; EMBASE; BIOSIS; Ovid and the relevant English orthopaedic journals and pooled data from ten eligible randomised controlled trials containing 738 patients to conduct a subgroup analysis according to different periods of follow-up. Our aim was to summarise the best available evidence.Results showed that compared with external fixation, internal fixation led to significantly fewer total surgical complications [95% confidence interval (CI) 0.39-0.81, P = 0.002] and reduced the incidence of pin-track infections (95% CI 0.08-0.46, P = 0.0002) after a one year follow-up. For clinical results, grip strength (95% CI 1.59-8.25, P = 0.004), supination (95% CI 13.99-48.83, P = 0.0004) and pronation (95% CI 5.61-26.09, P = 0.002) were superior in the internal fixation group six weeks postoperatively, and the same results were obtained three months postoperatively for grip strength (95% CI 3.21-13.47, P = 0.001) and supination (95% CI 3.61-16.01, P = 0.002). Meanwhile, the Disabilities of the Arm, Shoulder and Hand (DASH) score was superior in the internal fixation group at three months (95% CI -20.62 to -2.07, P = 0.02) and after one year (95% CI -14.37 to -2.32, P = 0.007) follow-up.We suggest that the final results are significant and there is some evidence supporting the use of open reduction and internal fixation.",
        "keywords": [
            "radius"
        ],
        "authors": [
            {
                "name": "Zhuang Cui",
                "org": "Orthopaedics and trauma, NanFang Hospital,Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Jianhong Pan",
                "org": "Department of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Orthopaedics and trauma, NanFang Hospital,Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Kairui Zhang",
                "org": "Orthopaedics and trauma, NanFang Hospital,Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Xiaolong Xiong",
                "org": "Orthopaedics and trauma, NanFang Hospital,Southern Medical University, Guangzhou, China"
            }
        ],
        "venue": "International orthopaedics",
        "year": 2011
    },
    "eYAwxs3w": {
        "id": "eYAwxs3w",
        "title": "Proteomic analysis on effectors involved in BMP-2-induced osteogenic differentiation of beagle bone marrow mesenchymal stem cells.",
        "abstract": "To identify the protein regulation profile of recombinant human bone morphogenetic protein-2 (rhBMP-2)-induced osteogenic differentiation in beagle bone marrow stem cells (BMSCs).Beagle BMSCs were isolated and cultured with or without rhBMP-2. Two-dimensional gel electrophoresis was used to determine the differences in protein expression in rhBMP-2-induced and non-induced BMSCs. Real-time PCR and western blotting analyses were used to verify the expression patterns of selected proteins.After the induction, the osteogenic differentiation of beagle BMSCs was activated successfully. Nine and 11 proteins were found to be down- and up-regulated by rhBMP-2, respectively. The increase in Lim and SH3 domain protein 1(LASP1) and the decrease in ferritin were verified by real-time PCR and western blotting analyses.Among the 20 rhBMP-2-regulated factors, there is empirical evidence supporting the involvement of LASP1 and ferritin in osteogenic differentiation. LASP1 plays an important role in the regulation of the activity of the cytoskeleton, and ferritin is an important molecule in cellular iron homeostasis. Further studies focused on these 20 proteins will help elucidate the molecular mechanism(s) through which rhBMP-2 induces osteogenic differentiation of BMSCs.",
        "keywords": [
            "proteomics",
            "bioinformatics",
            "biomedical research"
        ],
        "authors": [
            {
                "name": "Ji-Jie Hu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. hjj0610@163.com."
            },
            {
                "name": "Ya-Wei Liu",
                "org": "Department of Neurosurgery, Nanfang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Min-Yi He",
                "org": "Department of Organ Transplantation, Zhujiang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Dan Jin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Hui Zhao",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,China"
            }
        ],
        "venue": "Proteome science",
        "year": 2014
    },
    "gCLG0Qq1": {
        "id": "gCLG0Qq1",
        "title": "Calcium sulfate induced versus PMMA-induced membrane in a critical-sized femoral defect in a rat model.",
        "abstract": "Aimed to investigate the characteristics of CS-induced membrane in comparison with the PMMA-induced membrane. Cellular components, histological changes, growth factor expressions of IL-6, VEGF, BMP-2, and TGF-β1 in the two induced membranes were compared at 2, 4, 6 and 8 weeks, respectively. We also compared the histological changes at the bone defects between CS and PMMA groups. The structural characteristics of induced membrane were similar between CS and PMMA. Endochondral ossification took place in the CS-induced membrane at 8 week. Levels of VEGF, BMP-2 and TGF-β1 in CS-induced membrane were insignificantly higher than those in PMMA-induced membrane at different time points. The expression of IL-6 was significantly higher in PMMA-induced membranes at 2nd week. In addition, osteogenic and neovascular activities of induced membranes increased with time and peaked at 6 weeks. CS promoted endochondral ossification at the broken ends of the bone defect than PMMA did. CS-induced membrane has a better capacity of generating VEGF, BMP-2 and TGF-β1.osteogenic and neovascular activities achieve highest level at 6 week. CS may have the potential to replace PMMA as a novel spacer in Masquelet technique.",
        "keywords": "",
        "authors": [
            {
                "name": "Yun-Fei Ma",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Xiang Zhang",
                "org": "Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Cheng-He Qin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Lei Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Yan-Jun Hu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China. huyanjun1212@163.com."
            },
            {
                "name": "Qing-Rong Lin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China. yubinol01@163.com."
            },
            {
                "name": "Bo-Wei Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            }
        ],
        "venue": "Scientific reports",
        "year": 2018
    },
    "pJJm1YDx": {
        "id": "pJJm1YDx",
        "title": "Surgical versus nonsurgical treatment of displaced intra-articular calcaneal fracture: a meta-analysis of current evidence base.",
        "abstract": "Controversy still surrounds the optimal treatment for patients with displaced intra-articular calcaneal fractures (DIACF). An up-to-date meta-analysis was performed to evaluate clinical effectiveness of surgical treatment for DIACF compared with nonsurgical treatment.We systematically searched four electronic databases (Medline, BIOSIS, Cochrane library and Google Scholar) to identify randomised controlled trials (RCTs) and clinical controlled trials (CCTs) in which surgical treatment was compared with nonsurgical treatment of DIACF from 1980 to 2011. Trial quality was assessed using the modified Jadad scale and effective data were pooled for meta-analysis.Ten studies (six RCTs and four CCTs) with a total of 891 participants were screened. Results showed that surgical treatment was superior to nonsurgical treatment in better recovery of the Böhler angle (P < 0.0001), more stable calcaneal height (P = 0.0009) and width (P < 0.00001). Moreover, fewer surgically treated patients needed increased shoe size (P = 0.0004) and more were able to resume pre-injury work (P = 0.004) than the nonsurgical patients. No significant difference was identified between the two methods regarding the incidence of residual pain (P = 0.49). However, operative management was associated with a higher risk of complications (P = 0.008).Although surgical repair may increase the complication probability, it is the price that has to be paid for better reconstruction of the calcaneus and better functional results. Taken as a whole, surgery is probably the optimal choice in DIACF treatment.",
        "keywords": [
            "evidence based medicine"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, No.1838, Guangzhou Avenue North, Guangzhou, 510515, People's Republic of China."
            },
            {
                "name": "Qing-rong Lin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Xi-cai Diao",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Liang Wu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital,Southern Medical University,Guangzhou,People’s Republic of China"
            }
        ],
        "venue": "International orthopaedics",
        "year": 2012
    },
    "NBvd4tE4": {
        "id": "NBvd4tE4",
        "title": "Effect of platelet-rich plasma injection on early healing of Achilles tendon rupture in rats]",
        "abstract": "Platelet-rich plasma (PRP) can promote wound healing. To observe the effect of PRP injection on the early healing of rat's Achilles tendon rupture so as to provide the experimental basis for clinical practice.Forty-six Sprague Dawley rats were included in this experiment, female or male and weighing 190-240 g. PRP and platelet-poor plasma (PPP) were prepared from the heart arterial blood of 10 rats; other 36 rats were made the models of Achilles tendon rupture, and were randomly divided into 3 groups (control group, PPP group, and PRP group), 12 rats for each group. In PPP and PRP groups, PPP and PRP of 100 microL were injected around the tendons once a week, respectively; in the control group, nothing was injected. The tendon tissue sample was harvested at 1, 2, 3, and 4 weeks after operation for morphology, histology, and immunohistochemistry observations. The content of collagen type I fibers also was measured. Specimens of each group were obtained for biomechanical test at 4 weeks.All the animals survived till the end of the experiment. Tendon edema gradually decreased and sliding improved with time. The tendon adhesion increased steadily from 1 week to 3 weeks postoperatively, and it was relieved at 4 weeks in 3 groups. There was no significant difference in the grading of tendon adhesion among 3 groups at 1 week and at 4 weeks (P > 0.05), respectively. The inflammatory cell infiltration, angiogenesis, and collagen fibers were more in PRP group than in PPP group and control group at 1 week; with time, inflammatory cell infiltration and angiogenesis gradually decreased. Positive staining of collagen type I fibers was observed at 1-4 weeks postoperatively in 3 groups. The positive density of collagen type I fibers in group PRP was significantly higher than that in control group and PPP group at 1, 2, and 3 weeks (P < 0.05), but no significant difference was found among 3 groups at 4 weeks (P > 0.05). The biomechanical tests showed that there was no significant difference in the maximal gliding excursion among 3 groups at 4 weeks postoperatively (P > 0.05); the elasticity modulus and the ultimate tensile strength of PRP group were significantly higher than those of control group and PPP group at 4 weeks (P < 0.05).PRP injection can improve the healing of Achilles tendon in early repair of rat's Achilles tendon rupture.",
        "keywords": [
            "platelet-rich plasma achilles tendon rupture achilles tendon healing collagen type irat"
        ],
        "authors": [
            {
                "name": "Xiaolong Xiong",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Liang Wu",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Dayong Xiang",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Guoxin Ni",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Peiran Zhao",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Bin Yu",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2012
    },
    "a7k6DbpG": {
        "id": "a7k6DbpG",
        "title": "Epigallocatechin-3-gallate Promotes Osteoblastic Activity in Human Osteoblast-like Cells",
        "abstract": "Purpose: To investigate the effect of epigallocatechin-3-gallate (EGCG) on bone metabolism and osteoblastic activity. Methods: MG-63 human osteoblast-like cells were treated with varied concentrations of EGCG. Alkaline phosphatase (ALP) activity and matrix mineralization assays were carried out on the treated and untreated MG-63 human osteoblast-like cells. Beta-catenin mRNA level was determined by quantitative real-time polymerase chain reaction (q-PCR). Results: The results showed that EGCG treatment significantly increased ALP and mineralization activities at concentrations of 15 and 30 mu M, in a dose-dependent manner. Furthermore, EGCG treatment significantly increased beta-catenin mRNA expression by 70.7 +/- 11.0 and 126.7 +/- 35.1 %, respectively, at EGCG concentration of 15 and 30 mu M. In addition, the stimulating effect of EGCG treatment on ALP activity was abolished by co-treatment with ICI 182,780, an antagonist of estrogen receptor (ER). Again, the increase in beta-catenin MRNA, when treated with EGCG, was inhibited by co-treatment with ICI 182,780. Conclusion: EGCG promotes osteoblastic activity in human osteoblast-like cells, by Wnt signaling through estrogen receptor (ER) pathway.",
        "keywords": [
            "Epigallocatechin-3-gallate",
            "Osteoporosis",
            "Osteoclast",
            "Proliferation",
            "Estrogen receptor"
        ],
        "authors": [
            {
                "name": "Yuewen Peng",
                "org": "Southern Med Univ, Affiliated Nanfang Hosp, Dept Trauma Orthopaed, Guangzhou, Guangdong, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Med Univ, Affiliated Nanfang Hosp, Dept Trauma Orthopaed, Guangzhou, Guangdong, Peoples R China"
            },
            {
                "name": "Fang Liu",
                "org": "Second Hosp Yueyang, Dept Orthopaed, Yueyang, Peoples R China"
            }
        ],
        "venue": "TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH",
        "year": 2016
    },
    "a3t6sJQC": {
        "id": "a3t6sJQC",
        "title": "Chinese expert consensus on diagnosis and treatment of infection after fracture fixation.",
        "abstract": "Currently, accurate diagnosis and successful treatment of infection after fracture fixation (IAFF) still impose great challenges. According to the onset of infection symptoms after implantation, IAFF is classified as early infection (<2 weeks), delayed infection (2∼10 weeks) and late infection (>10 weeks). Confirmation of IAFF should be supported by histopathological tests of intraoperative specimens which confirm infection, cultures from at least two suspected infection sites which reveal the same pathogen, a definite sinus or fistula which connects directly the bone or the implant, and purulent drainage from the wound or presence of pus during surgery. Diagnosis of IAFF is built on comprehensive assessment of medical history, clinical signs and symptoms of the patient, and imaging and laboratory tests. The gold standard of diagnosis is histopathological tests. Treatment of IAFF consists of radical debridement, adequate irrigation, implant handling, systematic and local antibiotics, reconstruction of osseous and/or soft tissue defects, and functional rehabilitation of an affected limb. Early accurate diagnosis and appropriate treatment of IAFF play a key role in increasing the cure rate, reducing infection recurrence and disability risk, restoring limb function and improving quality of life of the patient.",
        "keywords": [
            "Chinese expert consensus",
            "Chronic osteomyelitis",
            "Diagnosis",
            "Fracture-related infections",
            "Treatment"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China."
            },
            {
                "name": "Bo-Wei Wang",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China."
            },
            {
                "name": "Yi-Min Chai",
                "org": "Department of Orthopaedics, The Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai, PR China."
            },
            {
                "name": "Xin-Bao Wu",
                "org": "Department of Orthopaedics & Traumatology, Beijing Jishuitan Hospital, Beijing, PR China. Electronic address: wuxinbao@jsthospital.org."
            },
            {
                "name": "Pei-Fu Tang",
                "org": "Department of Orthopaedics, Chinese PLA General Hospital, Beijing, PR China. Electronic address: pftang301@126.com."
            },
            {
                "name": "Ying-Ze Zhang",
                "org": "Department of Orthopaedics, The Third Hospital of Hebei Medical University, Shijiazhuang, PR China. Electronic address: yzling_liu@163.com."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China. Electronic address: yubin@smu.edu.cn."
            }
        ],
        "venue": "Injury",
        "year": 2019
    },
    "e2S1iRNw": {
        "id": "e2S1iRNw",
        "title": "Retrospective strategies for intramedullary nailing in the treatment of femoral shaft fractures",
        "abstract": "Objective: To retrospective determine current techniques and perioperative complications of intramedullary nailing of diaphyseal femoral fractures.Methods: 120 cases of diaphyseal femoral fractures were collected.Information about fracture classification,time to operation,injury severity score,type of nail,and operative technique,as well as perioperative complications such as infection,femoral neck fracture were selected.Results: The preferred position for implantation was supine(82.5%).Most surgeons used a traction table(57.1%) and an antegrade implantation technique(84.5%).In 59.2% of the cases,an isolated femur fracture was present,while the rest sustained multiple injuries.In polytrauma patients and patients with severe thorax injuries,most surgeons were chosed a delayed treatment with intramedullary femoral nails.Interestingly,38.0% of the patients with severe thorax injuries were treated on the first day with intramedullary femoral nails.The total rate of complications for intramedullary femoral nailing was low,but a high rate of intraoperative femoral neck fractures was observed.Conclusion: The vast majority of surgeons prefer the supine position and the antegrade technique to implant intramedullary femoral nails.The incidence rate of complication is low;A large number of polytrauma patients and patients with severe thoracic trauma are treated with intramedullary femoral nails on the first day of trauma.",
        "keywords": [
            "Bone fracture",
            "Diaphyseal femur",
            "Fixation",
            "Intramedullary pin"
        ],
        "authors": [
            {
                "name": "HAO Ting",
                "org": "Southern Medical University Affiliated Nanfang Hospital,Guangdong Province,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Southern Medical University Affiliated Nanfang Hospital,Guangdong Province,Guangzhou ,China"
            },
            {
                "name": "FENG Wei",
                "org": "Southern Medical University Affiliated Nanfang Hospital,Guangdong Province,Guangzhou ,China"
            },
            {
                "name": "HAO Zengtao",
                "org": "Southern Medical University Affiliated Nanfang Hospital,Guangdong Province,Guangzhou ,China"
            },
            {
                "name": "BAO Guoyu",
                "org": "Department of Orthopedics,the Second Affiliated Hospital of Inner Mongolia Medical College,Inner Mongolia Autonomous Region,Hohhot ,China"
            }
        ],
        "venue": "China Medical Herald",
        "year": 2011
    },
    "UFMiNrrx": {
        "id": "UFMiNrrx",
        "title": "The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis.",
        "abstract": "The objectives of this study were to observe the therapeutic effect of ozone (O3) of different concentrations on rat with rheumatoid arthritis (RA), and to investigate the role of O3 in regulating the level of TNF-α (tumor necrosis factor), TNF-R1 (tumor necrosis factor receptor 1), and TNF-R2. Forty-eight Wistar rats were randomly divided into eight groups. There are five O3 groups which were marked by 10, 20, 30, 40, and 50 μg/mL, respectively, control group, oxygen group, and RA model group. RA was induced in all rats by hypodermic injection of collagen II and complete Freund's adjuvant except that in the control group. At 21 days after modeling, the rats in oxygen group were given an injection of oxygen in the knee joint weekly for 3 weeks, and the rats in O3 groups were injected the concentration of O3 as they marked weekly for 3 weeks. The thickness of hind paw, as well as the serum and synovial levels of TNF-α, TNF-R1, and TNF-R2 was observed. At the end of treatments, the thickness of the hind paws in O3-40 group is much less compared to RA group (P < 0.01). The serum levels of TNF-α, TNF-R1, and TNF-R2 showed no significant difference among all the groups (P > 0.05). However, the synovial levels of TNF-α and TNF-R2 in O3-40 and O3-50 groups are lower than those in RA group (P < 0.01). The synovial level of TNF-R1 in O3-40 group is higher than that in RA group (P < 0.05). In conclusion, intra-articular injection of O3 at 40 μg/mL can effectively suppress the joint swelling caused by RA. This mechanism is probably mediated by down-regulating synovial TNF-α and TNF-R2 and up-regulating TNF-R1 in the joint.",
        "keywords": [
            "ozone",
            "rheumatoid arthritis",
            "tnf receptors",
            "tnf-α"
        ],
        "authors": [
            {
                "name": "Huiqiang Chen",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Changhuai Lu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Qingrong Lin",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "Rheumatology international",
        "year": 2013
    },
    "b0lvuY0o": {
        "id": "b0lvuY0o",
        "title": "Three-dimensional digital measurement of fixed parameters of the less invasive stable system fixation",
        "abstract": "BACKGROUND:The research has shown that the less invasive stable system(LISS) fixation has good effect on the treatment of distal femoral fractures,but its parameter was according to westerner,and the specification of a manufactured item is limited.OBJECTIVE:To digital measure the related anatomical CT data of LISS fixation in Chinese adults.METHODS:Fifteen cases imaging samples with no disease or osteoporosis were selected from the Second Affiliated Hospital of Inner Mongolia Medical College.The MIMICS10.01 software was used to do the three-dimensional reconstruction,the width of distal femur,anteroposterior diameter of condylus lateralis femoris,basilar part width of condylus lateralis femoris and angle between condylus lateralis femoris and trunk were measured in the three-dimensional images.Every 5 cm was divided into a segment from the 5 cm to the lower edge of the greater trochanter to the lateral epicondyle,five segments in total.The width of internal and lateral cortex and medullary cavity diameter of the femur in the central part of each segments were measured.RESULTS AND CONCLUSION:After LISS fixation in Chinese adults,the width and anteroposterior diameter of condylus lateralis femoris were(84.80±1.27) mm and(67.36±1.41) mm in the left and(84.60±1.40) mm and(66.27±1.42) mm in the right;the basilar part width of condylus lateralis femoris was(42.53±3.42) mm and(42.98±1.25) mm;the angle between condylus lateralis femoris and trunk was(7.58±0.69)° in the left and(7.66±0.79)° in the right,and there was no significant difference between two sides.",
        "keywords": [],
        "authors": [
            {
                "name": "Hao Ting",
                "org": "Department of Orthopedics,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Yu Bin",
                "org": "Department of Orthopedics,Nanfang Hospital of Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Hao Zeng-tao",
                "org": "Second Affiliated Hospital of Inner Mongolia Medical College,Hohhot ,Inner Mongolia Autonomous Region,China"
            },
            {
                "name": "Feng Wei",
                "org": "Second Affiliated Hospital of Inner Mongolia Medical College,Hohhot ,Inner Mongolia Autonomous Region,China"
            }
        ],
        "venue": "Chinese Journal of Tissue Engineering Research",
        "year": 2012
    },
    "Pc1Rn7FG": {
        "id": "Pc1Rn7FG",
        "title": "Effect of ozonated water on physical and chemical properties of vacuum sealing drainage material]",
        "abstract": "To investigate the influence of ozonated water on physical and chemical properties of vacuum sealing drainage (VSD) materials.VSD materials (foam and sealing membrane) were immersed in 10 µg/ml ozonated water for 1 h twice daily for 8 days. The foam appearance and microscopic structure of the materials were observed, and tensile tests and Raman spectrum scan were performed assess the effect of ozonated water. Simulated VSD devices were prepared and tested for leakproofness under negative pressure after ozonated water treatment.zonated water treatment for 8 days caused no obvious abnormal changes in the foam appearance or microscopic structure of the materials. The maximum tensile load of foam before and after ozonated water treatment was 4.25∓0.73 kgf and 2.44∓0.19 kgf (P=0.000), the momentary distance when the foam torn before and after intervention was 92.54∓12.83 mm and 64.44∓4.60 mm, respectively (P=0.000). The corresponding results for VSD sealing membrane were 0.70∓0.58 kgf and 0.71∓0.08 kgf (P=0.698), and 99.30∓10.27 mm and 100.95∓18.22 mm (P=0.966), respectively. Raman spectroscopy revealed changes in only several wave intensities and no new chemical groups appeared within the scan range of 400-4000 cm(-1). The VSD device was well hermetic after treatment with ozonated water.Except for a decreased stretch resistance property of the foam, VSD materials display no obvious changes in physical and chemical characteristics after treatment with ozonated water for 8 days.",
        "keywords": [
            "ozonated water",
            "vacuum sealing drainage"
        ],
        "authors": [
            {
                "name": "Nan Jiang",
                "org": ""
            },
            {
                "name": "Yunfei Ma",
                "org": ""
            },
            {
                "name": "Qingrong Lin",
                "org": ""
            },
            {
                "name": "Anfu Chen",
                "org": ""
            },
            {
                "name": "Peiran Zhao",
                "org": " Key Laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province,Guangzhou ,China"
            },
            {
                "name": "Guoxin Ni",
                "org": " Key Laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province,Guangzhou ,China"
            },
            {
                "name": "Bin Yu",
                "org": " Key Laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province,Guangzhou ,China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2013
    },
    "afe4PDsC": {
        "id": "afe4PDsC",
        "title": "Operational versus nonoperational treatment for mid-shaft clavicle fractures:a Meta-analysis",
        "abstract": "Objective To evaluate the effects of operational versus nonoperational treatment for mid-shaft clavicle fractures.Methods The randomized controlled trials(RCT) and quasi-randomized controlled trials(CCT) about operational versus nonoperational treatment for mid-shaft clavicle fractures were collected through computer search,manual search and other search methods and evaluated by the method that Cochrane Collaboration recommended.Results This study involved 301 cases overall and 4 RCT studies.The Meta analysis showed that:①there were statistical differences between the operation group and the nonoperation group.The non-union rate and malunion rate of the operation group were lower than that of the nonoperation group.The relative risk(RR) were 0.16 [95%CI(0.06,0.44),P =0.0004],0.10 [95%CI(0.03,0.32),P =0.0001] respectively;②The mean union-time of the operation group was lower than that of the nonoperation group,and the difference was statistically significant [WMD=-10.23;95%CI(-12.79,-7.66),P <0.00001].Conclusion Operation could signifiantly reduce the non-union rate and malunion rate of mid-shaft clavicle fractures compared with the nonoperation group.Meanwhile,operation could shorten mean union-time of mid-shaft clavicle fractures compared with the nonoperation group.Therefore,operation is a better choice for mid-shaft clavicle fracture.",
        "keywords": [
            "Meta-analysis",
            "Fractures",
            "Internal fixation",
            "Mid-shaft clavicle"
        ],
        "authors": [
            {
                "name": "XIONG Jun",
                "org": ",et al. Department of Traumatic Orthopaedics,Nanfang Hospital,South Medical University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al. Department of Traumatic Orthopaedics,Nanfang Hospital,South Medical University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "OUYANG Han-bin",
                "org": ",et al. Department of Traumatic Orthopaedics,Nanfang Hospital,South Medical University,Guangzhou,Guangdong ,China"
            }
        ],
        "venue": "Chinese Journal of Bone and Joint Injury",
        "year": 2012
    },
    "PIFiy0iA": {
        "id": "PIFiy0iA",
        "title": "Effect of intra-articular ozone injection on degenerative cartilage of the rat's knee",
        "abstract": "[Objective] To observe the effect of medical ozone on cartilage in the model of osteoarthritis(OA)to explore its therapeutic mechanism.[Method] Forty healthy adult SD rats were randomly divided into five groups :A(group normal)、B(group model)、C(group air),D(group O2~O3 35 μg/ml)and E(group O2~O3 70 μg/ml)(n=8 in each group).The OA model was duplicated by performed anterior eruciate ligament transection(ACLT)and partial meniscectomy of 1/3 inside.Air was injected into joints of group C,according to concentration different,which O2~O3 35 μg/ml and O2~O3 70 μg/ml were respectively injected into joints to D and E group every other day,every time 1～1.5 ml,and after a week injected again.After the model was successfully made,the condylar cartilage of femur was excised after 4 weeks for the observation by transmissive microscope of HE staining.Mankin's index was recorded.At the end of the experiment,douche fluid of the diseased joints were obtained for the measurements of superoxide dismutase(SOD)and malondialdehyde(MDA).[Result]The OA model in B group founded obviously degenerative changes under microscopy,resulting in mostly blue and green color destaining of Masson staining at superficial cartilage.The activity of SOD in the douche fluid of the diseased joints degraded and the quantity of MDA in the serum in the OA model group increased.The Mankin's index in the group D was significantly higher than that in the group B、 C(P< 0.05),which had no significant differences between group A,and obvious improvement were found in group D under microscopy,SOD levels increased and MDA levels degraded.There was no significant differences to group B in the Mankin's index.SOD levels degraded and MDA levels increased.[Conclusion]Thirty-five μg/ml O3 can prevent degeneration of articular cartilage,improve the ability to clear free radical.There is reasonable effect for the treatment of OA,but 70 μg/ml O3 resultes peroxidatic reaction tissue and cell,which resultes to destroy of articular cartilage.",
        "keywords": [
            "MDA",
            "ozone",
            "joint cartilage",
            "SOD",
            "degenerative arthritis"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": ",et al.Depantment of Traumatic Orthopedics,Nanfang Hospital,Nanfang Medical University,Guangzhou,,China"
            },
            {
                "name": "ZHU Quan",
                "org": ",et al.Depantment of Traumatic Orthopedics,Nanfang Hospital,Nanfang Medical University,Guangzhou,,China"
            },
            {
                "name": "HU Yan-jun",
                "org": ",et al.Depantment of Traumatic Orthopedics,Nanfang Hospital,Nanfang Medical University,Guangzhou,,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2008
    },
    "1a95xrFQ": {
        "id": "1a95xrFQ",
        "title": "Combined measurement of plasma cystatin C and low-density lipoprotein cholesterol: A valuable tool for evaluating progressive supranuclear palsy.",
        "abstract": "•Higher plasma Cys C levels in patients with PSP than in healthy controls.•Lower plasma LDL-C levels in patients with PSP than in healthy controls.•Significantly positive correlation of Cys C/LDL-C/HDL-C ratio in PSP patients.•Better discrimination between PSP patients and healthy subjects by the ROC curve of combined measurement of Cys C and LDL-C.",
        "keywords": [
            "Progressive supranuclear palsy",
            "Cystatin C",
            "Low-density lipoprotein cholesterol",
            "Neurocognitive disorder"
        ],
        "authors": [
            {
                "name": "Ruihui Weng",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Xiaobo Wei",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Rehabilitation, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Shuzhen Zhu",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Xiaohua Yang",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Fen Xie",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Mahui Zhang",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Ying Jiang",
                "org": "Department of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China"
            },
            {
                "name": "Zhong-Ping Feng",
                "org": "Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada"
            },
            {
                "name": "Hong-Shuo Sun",
                "org": "Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada"
            },
            {
                "name": "Ying Xia",
                "org": "Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai, China"
            },
            {
                "name": "Kunlin Jin",
                "org": "Department of Neurosurgery, University of Texas Medical School at Houston, Houston, TX, USA"
            },
            {
                "name": "Piu Chan",
                "org": "Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China"
            },
            {
                "name": "Qing Wang",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            },
            {
                "name": "Xiaoya Gao",
                "org": "Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China"
            }
        ],
        "venue": "Parkinsonism & Related Disorders",
        "year": 2018
    },
    "ZaKEFcMa": {
        "id": "ZaKEFcMa",
        "title": "Using three-dimensional computational modeling to compare the geometrical fitness of two kinds of proximal femoral intramedullary nail for Chinese femur.",
        "abstract": "The aim of this study was to use three-dimensional (3D) computational modeling to compare the geometric fitness of these two kinds of proximal femoral intramedullary nails in the Chinese femurs. Computed tomography (CT) scans of a total of 120 normal adult Chinese cadaveric femurs were collected for analysis. With the three-dimensional (3D) computational technology, the anatomical fitness between the nail and bone was quantified according to the impingement incidence, maximum thicknesses and lengths by which the nail was protruding into the cortex in the virtual bone model, respectively, at the proximal, middle, and distal portions of the implant in the femur. The results showed that PFNA-II may fit better for the Chinese proximal femurs than InterTan, and the distal portion of InterTan may perform better than that of PFNA-II; the anatomic fitness of both nails for Chinese patients may not be very satisfactory. As a result, both implants need further modifications to meet the needs of the Chinese population.",
        "keywords": [
            "computer simulation",
            "cadaver"
        ],
        "authors": [
            {
                "name": "Sheng Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Kairui Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yimin Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wei Feng",
                "org": "Second Affiliated Hospital to Inner Mongolia Medical University(Second Affiliated Hospital to Inner Mongolia Medical University),,China"
            },
            {
                "name": "Bowei Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "TheScientificWorldJournal",
        "year": 2013
    },
    "3UG3gSRD": {
        "id": "3UG3gSRD",
        "title": "Efficacy and safety of simultaneous bilateral total hip arthroplasty:a meta-analysis",
        "abstract": "[Objective]To compare efficacy and safety of simultaneous bilateral total hip arthroplasty with those of staged process. [Method]The Cochrane library,MEDLINE(1966-2011),EMbase(1966-2011),CBM(1979-2011) and relevant English and Chinese orthopedic journals were searched for the randomized controlled clinical trials(RCTs) of simultaneous versus staged bilateral total hip arthroplasty.A systematic review was performed using the method recommended by the Cochrane Collaboration. [Result]A total of 11 RCTs with a total of 2011 participants were included.The meta-analysis showed no significant differences in the mortality and major complication rate between the two groups,with cardiovascular event(RR=1.19,P=0.59),pulmonary embolism(RR=1.58,P=0.3),deep vein thrombosis(RR=0.66,P=0.45).Compared with staged bilateral hip arthroplasty,simultaneous group had a higher risk of local infection(P=0.002,RR=2.72),dislocation(RR=2.41,P=0.02) and revision(RR=2.11,P=0.03).The average operation time(P<0.001)and hospital stay(P<0.000 01) were significantly shorter in the simultaneous group.Blood loss volume were similar in the two groups(P=0.94). [Conclusion]Taking into account of the complication rate and efficacy,one-stage has increased local complication rate compared with staged process of bilateral total hip arthroplasty.However,more high quality,large-scale randomized clinical trials are required for more accurate conclusions.",
        "keywords": [
            "simultaneous",
            "Meta-analysis",
            "staged process",
            "bilateral total hip arthroplasty"
        ],
        "authors": [
            {
                "name": "XIANG Peng",
                "org": ",et al.Department of Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "XIONG Jun",
                "org": ",et al.Department of Orthopedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2012
    },
    "zHUK5viu": {
        "id": "zHUK5viu",
        "title": "Construction and analysis of a finite-element model of patella fracture fixed with AO tensile force girdle",
        "abstract": "BACKGROUND:Currently,most of biomechanical research about internal fixation of patellar fracture has been carried out by corpse.Few researchers carried out it using modern finite element method.OBJECTIVE:To establish the finite element model of patella fracture fixed with AO tensile force girdle and to perfore finite element mechano-analysis.METHODS:An adult female volunteer was selected,underwent a lamellar computed tomography (CT) scan on the lower extremity,extract right patella's polylines by Mimics10.01 software and construct geometrical models.Then the geometrical model was imported into PRO/E 2.0 software,to simulate bone fracture by intersected function of PRO/E 2.0 software and generate two bent Kirschner wires and annular steel-wire,rebuild 3D model of patella fracture fixed with AO tensile force girdle.After that,the model was imported into the ANSYS software to constructe 3D finite-element models that analyzing displacement and deformation features simulating patellofemoral joint under 600 N loading at 90° knee bending.RESULTS AND CONCLUSION:The AO tensile force girdle could force patella fracture in many ways,and opposed to tensile force of musculus quadriceps fexoris.The finite element analytic result coincides with biomechanical result.The 3D finite-element model of patella fracture fixed with AO tensile force girdle was scientific,which is beneficial to better understanding of the biomechanical principle about patella fracture fixed with AO tensile force girdle and provides clinical instruction.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Xu Hong-zhang",
                "org": " Department of Orthopaedic Traumatics,Nanfang Hospital,Southern Medical University,Guangzhou ,Guangdong Province,China"
            },
            {
                "name": "Yu Bin",
                "org": " Department of Orthopaedic Traumatics,Nanfang Hospital,Southern Medical University,Guangzhou ,Guangdong Province,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2011
    },
    "Q3yxosJV": {
        "id": "Q3yxosJV",
        "title": "Pigmented villonodular synovitis: a retrospective multicenter study of 237 cases.",
        "abstract": "To review clinical characteristics of pigmented villonodular synovitis (PVNS) in China.Electronic medical records (EMR) of four Chinese institutes were queried for patients with histologically proven PVNS between January 2005 and February 2014. Their data were collected including gender, age at diagnosis, clinical presentation, affected site, symptom duration, comorbidities, treatment strategy, recurrence and routine laboratories.A total of 237 patients with biopsy-proven PVNS were investigated. The gender ratio was 1.35 for a female predominance (101 males and 136 females). The average age was 36 years (range, 2 to 83 years). The median delay from initial clinical symptom to diagnosis was 18 months. Main affected areas were the knee (73.84%) and the hip (18.14%). Forty patients had a clear history of joint trauma. Six patients were concurrently diagnosed with PVNS and avascular necrosis (AVN). Five patients suffered from PVNS following implantation of orthopaedic devices including artificial prosthesis, plate and wire. One hundred and twenty-nine patients underwent arthroscopic synovectomy and 108 open synovectomy. Altogether 48 patients (26 males and 22 females) had recurrence of disease. The relapse rate was 24% (knee) and 6.98% (hip), 20.93% (open surgery) and 19.44% (arthroscopy), respectively. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) rate were elevated in 45.83% and 38.41% of the patients respectively.To our knowledge, this study is the largest sample size of PVNS patients reported as well as the largest sample of PVNS with concurrent AVN reported to date. Our outcomes suggest that PVNS shows a female predominance, occurs mostly between 20-40 years and favors the knee and hip. Recurrence is frequent, particularly in the knee. Serum ESR and CRP may be elevated in some patients. Additionally, the present study supports the theory of an association between PVNS and orthopedic surgery, which is not limited to joint replacement.",
        "keywords": [],
        "authors": [
            {
                "name": "Guo-ping Xie",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China; Key laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Chang-xiang Liang",
                "org": "Department of Orthopaedics, Guangdong General Hospital, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Jian-chun Zeng",
                "org": "Department of Third Orthopaedics, The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Zhi-yuan Chen",
                "org": "Department of Overseas Chinese Patients, General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Qian Xu",
                "org": "Department of Health Statistics, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Rui-zhen Qi",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Yi-rong Chen",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China; Key laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China."
            }
        ],
        "venue": "PloS one",
        "year": 2015
    },
    "KvZhpJTg": {
        "id": "KvZhpJTg",
        "title": "Combination of bone cement filling and plate internal fixation with limb salvage is used for metastatic malignant bone tumors",
        "abstract": "Background: Currently, limb salvage therapy has become the standard treatment of malignant bone tumors way, but improper treatments will result in tumor recurrence, secondary infection, internal fixation or prosthesis loosening. Objective: Based on the traditional surgical principle for metastatic bone tumors of the limbs, this study designed a user-friendly, individualized, simplistic palliative treatment regimen from the actual conditions of patients to observe the reasonability, clinical efficacy and prognosis of bone cement filling combined with internal fixation in the treatment of metastatic malignant bone tumors. Methods: Thirty-one patients with metastatic malignant bone tumors who required salvage treatment were screened from the Department of Orthopedics, the 421 Hospital of Chinese PLA, and their clinical data were retrospectively analyzed. All the 31 patients were divided into two groups: tumor removal+internal fixation group (non-chemoradiotherapy group, n=11) treated with bone cement filling plus plate internal fixation (palliative treatment); tumor removal+internal fixation+chemoradiotherapy group (chemoradiotherapy group, n=20), treated with radiotherapy before internal fixation plus plate internal fixation with limb salvage. The follow-up period was 4-38 months, averagely 18 months. Results and Conclusion: The follow-up results showed that in the non-chemoradiotherapy group, all the 11 patients survived, who could live independently and have good motor functions; in the chemoradiotherapy group, 17 of the 20 patients survived and the rest three patients died of tumor metastasis, their poor conditions and complications at 9 and 13 months after internal fixation. In patients undergoing tumor removal+plate internal fixation with limb salvage, the integrated scores for nerve and motor functions were increased by more than level 1. These findings confirm that a simple palliative therapy of bone cement filling and internal fixation without chemoradiotherapy is better for metastatic malignant bone tumors patients who require limb salvage.",
        "keywords": [
            "Biomaterials",
            "Bone cement",
            "Bone tumor",
            "Chemotherapy",
            "Internal fixation",
            "Limb salvage treatment",
            "Malignant tumor",
            "Metastasis",
            "Pathological fracture",
            "Radiotherapy",
            "Retrospective analysis",
            "Tissue-engineered bone materials"
        ],
        "authors": [
            {
                "name": "Jun Yang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Guo Xin-hui",
                "org": "No 421 Hospital of PLA(The 421 Hospital of Chinese PLA),Guangzhou,China"
            },
            {
                "name": "Peng Yang",
                "org": "Second Affiliated Hospital of Inner Mongolia Medical University(Second Affiliated Hospital of Inner Mongolia Medical University,The Second Affiliated Hospital of Inner Mongolia Medical University),,China"
            },
            {
                "name": "Zhang Kai-rui",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Sheng Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Cai Wei-bin",
                "org": "No 421 Hospital of PLA(The 421 Hospital of Chinese PLA),Guangzhou,China"
            },
            {
                "name": "Ku Jian-bin",
                "org": "No 421 Hospital of PLA(The 421 Hospital of Chinese PLA),Guangzhou,China"
            },
            {
                "name": "Tian Ling-yan",
                "org": "No 421 Hospital of PLA(The 421 Hospital of Chinese PLA),Guangzhou,China"
            }
        ],
        "venue": "Chinese Journal of Tissue Engineering Research",
        "year": 2013
    },
    "DJohKFf1": {
        "id": "DJohKFf1",
        "title": "Expression and significance of TGF-β1 and VEGF in an Achilles tendon section model after application of platelet-rich plasma",
        "abstract": "Objective To observe the expression of transforming growth factor β1(TGF-β1)and vascular endothelial growth factor(VEGF)in an Achilles tendon section model after application of platelet-rich plasma for investigation of the molecular mechanisms,and further explore the influences of PRP in Achilles tendon healing.Methods Forty-six health Sprague Dawley rats,weighing 150-250 g and male or female,were randomly divided into 3 groups(control group,PRP group,PPP group),12 rats for each group.PRP was prepared form the rest of the ten rats.rats were established tendon injury models by cutting the Achilles tendon.A volume of 100 μl of PRP was then injected into the tendon mass in the PRP group once a week,100 μl PPP was injected in the PPP group,and nothing in the control group.Equal numbers of animals were sacrificed at 1st,2nd,3rd,and 4th week after operation for histological and immunohistochemical observations.Results Immunohistochemical staining showed the expression of VEGF and TGF-β1in PRP group was up-regulated at 1 week and 2 weeks,and subsequently down-regulated at 3 and 4 weeks,but in PPP and control group didnit decrease significantly,the expression of TGF-β1 showed significant differences between PRP groups and the rest of the two groups at each time point(P<0.05);the expression of VEGF showing significant differences between PRP groups and the rest of the two groups at 1 week to 3 week,but not at 4 week(P<0.05).There were no differences between the PPP group and the control group at each time point(P>0.05).Conclusions Our research suggests that the PRP may facilitate the tendon healing process,which may be associated with its altering the expression of VEGF and TGF-β1.",
        "keywords": [
            "Vascular endothelial growth factor",
            "Achilles tendon",
            "Transforming growth factor beta1",
            "Platelet-rich plasma"
        ],
        "authors": [
            {
                "name": "WU Liang",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "XIONG Xiao-long",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "XIANG Da-yong",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "NI Guo-xin",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ".Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Clinicians(Electronic Edition)",
        "year": 2013
    },
    "W3By13SJ": {
        "id": "W3By13SJ",
        "title": "Effects of exercise intensities on expression of hypoxia inducible factor-1α mRNA in the skeletal muscle of rats",
        "abstract": "Objective To study effects of exercise intensities and durations on expression of hypoxia inducible factor-1α mRNA in the skeletal muscle of rats. Methods Eighty rats were randomized into control group, low-intensity exercise group, moderate-intensity exercise group and high-intensity exercise group. Each group was further divided into four sub-groups in which rats were trained on the treadmill for one day, three days, seven days and 14 days respectively. Then cells of the skeletal muscle were observed under a transmission electron microscope and the expression of HIF-1α mRNA was detected by RT-PCR. Results HIF-1α mRNA could be basically expressed in control group during the 14 days. By contrast, there was a significant increase of HIF-1α mRNA in low-intensity exercise group at day 7(P< 0.05). The expression of HIF-1α mRNA in moderate-intensity exercise group increased significantly at both day 3 and day 7(P< 0.05). The same results were observed in high-intensity exercise group, but had no significant difference compared with those in moderate-intensity exercise group(P >0.05). At day 14, however, there was little significant difference in the result among all the groups (P >0.05). The observation by electron microscope revealed disordered skeletal muscle myofilaments, obvious swelling and partial vacuolization of mitochondria in high-intensity exercise group at day 14. Conclusions Appropriate exercise with appropriate duration can improve expression of HIF-1α mRNA in the skeletal muscle of rats which might be a positive mechanism to adjust to the exercise. Although different exercise intensities have little effect on the expression of HIF-1α mRNA, constant high-intensity exercise may damage skeletal muscles in rats.",
        "keywords": [
            "Hypoxia inducible factor-1α (HIF-1α )",
            "Messenger RNA",
            "Skeletal muscle",
            "Exercise"
        ],
        "authors": [
            {
                "name": "ZHANG Xing",
                "org": " * Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , ChinaSupported by Guangdong Provincial Foundation for Natural Sciences %%#31%%#Corresponding author: YU Bin"
            },
            {
                "name": "YU Bin",
                "org": " * Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , ChinaSupported by Guangdong Provincial Foundation for Natural Sciences %%#31%%#Corresponding author: YU Bin"
            },
            {
                "name": "CAI Bao-ta",
                "org": " * Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou , ChinaSupported by Guangdong Provincial Foundation for Natural Sciences %%#31%%#Corresponding author: YU Bin"
            }
        ],
        "venue": "Chinese Journal of Orthopaedic Trauma",
        "year": 2006
    },
    "HLWHCE4N": {
        "id": "HLWHCE4N",
        "title": "Landmark-based automatic registration of serial cross-sectional images of Chinese digital human using Photoshop and Matlab software]",
        "abstract": "This paper describes automatic registration of the serial cross-sectional images of Chinese digital human by projective registration method based on the landmarks using the commercially available software Photoshop and Matlab. During cadaver embedment for acquisition of the Chinese digital human images, 4 rods were placed parallel to the vertical axis of the frozen cadaver to allow orientation. Projective distortion of the rod positions on the cross-sectional images was inevitable due to even slight changes of the relative position of the camera. The original cross-sectional images were first processed using Photoshop software firstly to obtain the images of the orientation rods, and the centroid coordinate of every rod image was acquired with Matlab software. With the average coordinate value of the rods as the fiducial point, two-dimensional projective transformation coefficient of each image was determined. Projective transformation was then carried out and projective distortion from each original serial image was eliminated. The rectified cross-sectional images were again processed using Photoshop to obtain the image of the first orientation rod, the coordinate value of first rod image was calculated using Matlab software, and the cross-sectional images were cut into images of the same size according to the first rod spatial coordinate, to achieve automatic registration of the serial cross-sectional images. sing Photoshop and Matlab softwares, projective transformation can accurately accomplish the image registration for the serial images with simpler calculation processes and easier computer processing.",
        "keywords": [
            "serial images",
            "matlab",
            "projective transformation",
            "projective distortion",
            "image registration",
            "chinese digital human",
            "photoshop"
        ],
        "authors": [
            {
                "name": "Xiu-yun Su",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Guo-xian Pei",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Bin Yu",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Yan-ling Hu",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Jin Li",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Qian Huang",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Xu Li",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            },
            {
                "name": "Yuan-zhi Zhang",
                "org": " Department of Traumatology and Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou , China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2007
    },
    "ismnUFAV": {
        "id": "ismnUFAV",
        "title": "Quantitative proteomics reveals ELP2 as a regulator to the inhibitory effect of TNF-α on osteoblast differentiation.",
        "abstract": "TNF-α, one of the most potent pro-inflammatory cytokines, plays a critical role in inhibition of osteoblast differentiation and bone regeneration in persistent inflammatory microenvironment. To explore the mechanism, quantitative proteomics based on iTRAQ and MRM was employed. The results showed 6 proteins involved in BMP-2 induced osteoblast differentiation inhibition by TNF-α: Periostin, Protein S100-A4, ATPase inhibitor, Cytochrome b5, SERCA3, and ELP2. The altered proteins were involved in molecular transport, tissue development, energy metabolism, and inflammation. One specific protein, ELP2 (STAT3-interacting protein 1, StIP1) up-regulated in the inhibition of osteoblast differentiation by TNF-α was verified to play a critical role in STAT3 pathway. Overexpression or knockdown of ELP2 in C2C12 and MC3T3-E1 cells affected osteoblast differentiation inhibition induced by TNF-α. These results highlight the function of ELP2 in inflammatory microenvironment, ELP2 up-regulation and STAT3 pathway activation may down-regulate BMPR2, then BMP-2 was blocked and osteoblast differentiation inhibited. The protein-expression profile revealed here should offer at least partly new clues to understand the mechanism of osteoblast differentiation inhibition by inflammation.Persistent inflammation is always associated with osteogenesis and affects this balance to reduce bone mass including traumatic open bone fracture, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), but the cellular mechanisms are not fully elucidated. Tumor necrosis factor-α (TNF-α) is one of the most potent pro-inflammatory cytokines and is known to be a catabolic factor in these inflammatory reaction of diseases. We show for the first time using proteomics methods that in inflammatory microenvironment, osteoblast differentiation will be inhibited by TNF-α induced ELP2 up-regulation and STAT3 pathway activation. Our results are significant since they point to targeting ELP2 activity as a novel therapeutic option to limit the inhibition of osteoblast differentiation by inflammatory microenvironment.",
        "keywords": [
            "elp2",
            "mrm",
            "osteoblast differentiation",
            "quantitative proteomics",
            "tnf-α",
            "itraq"
        ],
        "authors": [
            {
                "name": "Chang-Peng Xu",
                "org": "Guangzhou Institute of Traumatic Surgery, The Fourth Affiliated Hospital of Medical College, Jinan University, Guangzhou, Guangdong, People's Republic of China; Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Xue Li",
                "org": "Department of Orthopaedics, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong, People's Republic of China; Key Laboratory of Bone and Cartilage Regenerative Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Yan-Jun Hu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Zhuang Cui",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Lei Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Liang Liang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Yi-Lin Zhou",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China."
            },
            {
                "name": "Ya-Jun Yang",
                "org": "Department of Pharmacology, Guangdong Medical College, Zhanjiang, Guangdong, People's Republic of China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China. "
            }
        ],
        "venue": "Journal of proteomics",
        "year": 2015
    },
    "31pRZsh9": {
        "id": "31pRZsh9",
        "title": "Dynamic versus static external fixation for unstable distal radius fractures: an up-to-date meta-analysis.",
        "abstract": "Whether dynamic or static external fixation is more appropriate for distal radius fractures is still being debated, our aim is to determine the effect of dynamic versus static external fixation for unstable distal radius fractures in terms of postoperative complication, clinical results and radiological outcomes.We selected PubMed, Cochrane Library, EMBASE, BIOSIS, Ovid and the relevant English orthopaedic journals and pooled data from eligible trials including six eligible randomised controlled trials and two comparative studies containing 998 patients comparing dynamic and static external fixation for unstable distal radius fractures to conduct a sub-group analysis according to different periods of follow-up, aiming to summarise the best available evidence.The results showed there was an increased risk for pin-track infection in dynamic external fixation group than that in static external fixation group, however, there was the trend of obtaining better clinical effect towards less malunion in dynamic external fixation group, although the results were not statistically significant. With regard to clinical results, range of motion such as extension, supination and pronation were superior in dynamic external fixation group than that in static external fixation group at 6 weeks postoperatively. And there were the trend of obtaining better clinical effect in dynamic external fixation group towards pronation at one year follow-up and grip strength at six weeks, six months and one year follow-up, although no significant differences were viewed. With regard to radiological outcomes, better clinical result was obtained in terms of radial length in dynamic external fixation group immediately after surgery and at six weeks, one year follow-up postoperatively.The final results show that there are some evidences supporting the use of dynamic external fixation, which may also have practical advantages over static fixation by allowing earlier limb mobility during the fixation period and enabling such patients to maintain their independence. Limitations remain, a cost-effectiveness analysis and DASH-score assessments at all follow-up evaluations should be more carefully considered and reported in a reliable, consistent and standardised manner.",
        "keywords": [
            "meta analysis"
        ],
        "authors": [
            {
                "name": "Zhuang Cui",
                "org": "Orthopedics and Trauma, NanFang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Yanjun Hu",
                "org": ""
            },
            {
                "name": "Qingrong Lin",
                "org": ""
            },
            {
                "name": "Bowei Wang",
                "org": ""
            }
        ],
        "venue": "Injury",
        "year": 2012
    },
    "KLZN33v2": {
        "id": "KLZN33v2",
        "title": "Study on bone marrow mesenchymal stem cells derived osteoblasts and endothelial cells compound with chitosan/hydroxyapatite scaffold to construct vascularized tissue engineered bone]",
        "abstract": "Objective To explore the osteogenesis and angiogenesis effect of bone marrow mesenchymal stem cells(BMSCs) derived osteoblasts and endothelial cells compound with chitosan/hydroxyapatite(CS/HA) scaffold in repairing radial defect in rats.Methods The BMSCs were isolated from Sprague Dawley rats and the 3rd generation of BMSCs were induced into osteoblasts and endothelial cells.The endothelial cells,osteoblasts,and mixed osteoblasts and endothelial cells(1∶ 1) were compound with CS/HA scaffold in groups A,B,and C respectively to prepare the cell-scaffold composites.The cell proliferation was detected by MTT.The rat radial segmental defect model was made and the 3 cell-scaffolds were implanted,respectively.At 4,8,and 12 weeks after transplantation,the graft was harvested to perform HE staining and CD34 immunohistochemistry staining.The mRNA expressions of osteopontin(OPN) and osteoprotegerin(OPG) were detected by RT-PCR.Results Alkaline phosphatase staining of osteoblasts showed that there were blue grains in cytoplasm at 7 days after osteogenic induction and the nuclei were stained red.CD34 immunocytochemical staining of the endothelial cells showed that there were brown grains in the cytoplasm at 14 days after angiogenesis induction.MTT test showed that the proliferation level of the cells in 3 groups increased with the time.HE staining showed that no obvious osteoid formation,denser microvessel,and more fibrous tissue were seen at 12 weeks in group A;homogeneous osteoid which distributed with cord or island,and many osteoblast-like cells were seen in groups B and C.The microvessel density was significantly higher in groups A and C than group B at 3 time points(P < 0.05),and in group A than in group C at 12 weeks(P < 0.05).The OPN and OPG mRNA expressions of group A were significantly lower than those of groups B and C at 3 time points(P < 0.05).In groups B and C,the OPN mRNA expressions reached peak at 8 and 12 weeks,respectively,and OPG mRNA expressions reached peak at 4 weeks.Conclusion BMSCs derived osteoblasts and endothelial cells(1∶ 1) compound with CS/HA porous scaffold can promote bone formation and vascularization in bone defect and accelerate the healing of bone defect.",
        "keywords": [
            "Bone marrow mesenchymal stem cells Tissue engineered bone Vascularization Bone defect Rat"
        ],
        "authors": [
            {
                "name": "Zengtao Hao",
                "org": "Department of Trauma and Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou Guangdong, 510515, P.R.China."
            },
            {
                "name": "Wei Feng",
                "org": "Department of Orthopaedics,Second Hospital Affiliated to Inner Mongolia Medical College"
            },
            {
                "name": "Tini Hao",
                "org": "Department of Orthopaedics,Second Hospital Affiliated to Inner Mongolia Medical College"
            },
            {
                "name": "Bin Yu",
                "org": ".1Department of Trauma and Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2012
    },
    "ifizWzOP": {
        "id": "ifizWzOP",
        "title": "Reamed versus unreamed intramedullary nailing for closed tibial fractures:a systematic review",
        "abstract": "[Objective]This paper comments on the effect of the reamed versus unreamed intramedullary nailing(RTN and UTN) treatment for closed tibial fractures. [Method]The randomized controlled trials(RCT) and quasi-randomized controlled trials(CCT) about reamed or unreamed intramedullary nailing for closed tibial fractures were collected through computer search,manual search and other search methods with the method recommended by Cochrane Collaboration. [Result]This study involved 6 RCT studies,and a total of 1214 cases.The Meta analysis showed that:(1) there were statistical differences between the RTN group and the UTN group.The non-union rate of the RTN group was lower than that of the UTN group(RR = 0.41;95% CI(0.21,,0.78),P= 0.007);(2) The failure rate of the RTN group was lower than that of the UTN group,and the difference was statistically significant(RR = 0.32;95% CI(0.20,0.50),P<0.0001);(3) There was no statistically significant difference between the RTN group and the UTN group in the incidence of postoperative malunion and infection.The relative risk were 0.45(95% CI(0.0.16,1.22),P=0.12) and 0.45(95% CI(0.13,2.16),P= 0.38),respectively. [Conclusion]The research result indicated that,RTN can reduce the non-union rate or implant failure rate of closed tibial fractures compared with the UTN.Therefore,RTN is a better choice.However,due to the limitation of the quality of literature and the number of the samples,the result needs to be further confirmed with the randomized controlled trial of the large multi-center samples.",
        "keywords": [
            "meta-analysis",
            "closed tibial fractures",
            "internal fixation",
            "intramedullary nail"
        ],
        "authors": [
            {
                "name": "XIONG Jun",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,South Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,South Medical University,Guangzhou ,China"
            },
            {
                "name": "OUYANG Han-bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,South Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2011
    },
    "RQRpJfL7": {
        "id": "RQRpJfL7",
        "title": "Biomechanical changes of proximal femur for posteriomedial fractures:a finite element analysis",
        "abstract": "[Objective]To research the biomechanical influence of posteriomedial fractures on proximal femur.[Method]Three dimensional finite element models of intact and osteotomied proximal femurs were established from computerized tomographic(CT)scanning images,and finite element analysis was undertaken.[Result]The maximum equivalent stress was located at the anteriomedial of the defection of the proximal femur.The stress of femoral neck,as well as the medial and lateral femoral cortex was not significantly changed after isolated lesser trochanteric fracture.However,with half of the medial cortex involved,the stress of the medial and lateral femur increased by 47% and 12%,respectively.If the entire medial cortex was involved,the stress of medial and lateral femur increased by 247% and 66%,respectively.[Conclusion]Different types of posteriomedial fragments have different effects on the stress distribution and quantity of proximal femur.When treating intertrochanteric fractures using dynamical hip screw,the fragments should be differently treated based on its types considering for biomechanical effects.",
        "keywords": [
            "lesser trochanter",
            "finite element",
            "biomechanics",
            "fracture",
            "femur"
        ],
        "authors": [
            {
                "name": "HUANG Meng-quan",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LIN Chun-xiu",
                "org": ",et al.Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2010
    },
    "ItzCjMCZ": {
        "id": "ItzCjMCZ",
        "title": "Virtual clinical anatomy measurement of digital tissue flap",
        "abstract": "Background:In recent years,digital technology has become one of the hottest and most advanced topics in the field of orthopedic surgery and microsurgery,which have achieved remarkable progress in reconstructing the digital model of the bone and joint and developing virtual surgery system.For example,a three-dimensional tissue flap model could be established using digital virtual technology,which,compared with traditional methods,gives a more intuitive and personalized view for the surgeons.Therefore,it is expected to provide more accurate and detailed anatomical data for clinical studies.Objective:To evaluate the application of digital three-dimensional tissue flap in anatomic measurement.Methods:Six adult volunteers underwent contrast-enhanced CT angiography of pelvic and lower limbs by a 64-row multi-slice spiral CT after median cubital vein injection with Ultravist(3.5 ml/s).Two-D images from these data in Dicom format were transformed into computer.Two adult fresh cadaver specimens,one male and one female,were subjected to radiographic CT scanning before and after perfused with lead oxide-gelatine mixture,with collimation of 0.5 mm.Through Amira 4.1(TGS) software,the 2-D images in Dicom format were transformed into the 3-D models of the entire region.Amira 4.1 was used for 3-D reconstruction and 3-D display of gastrocnemius flap and iliac bone flap to observe the main flap artery type,the number of perforator vessels,the diameter of the main and perforator vessels,the tube pedicle length and distribution of anatomical specimens compared with the tissue flap data.Results:The data of the digital flap model complied with that of the skin specimens.The small perforator vessels and the distribution of vascular network could be clearly observed in the model perfused with lead oxide-gelatine mixture.The diameter of blood vessel was larger than the normal one due to the perfusion pressure in the reconstruction model.However,the diameter was smaller by CT angiographic reconstruction.Conclusions:Digital reconstruction technology can visualize directly the tissue flap in 3-D anatomical morphology.It canbe used as a new method for microsurgery and anatomy teaching to overcome the inadequacy of body specimens.Furthermore,it will provide new insight into gross anatomy measurement.",
        "keywords": [
            "digitalization",
            "gastrocnemius flap",
            "anatomical measurements",
            "three-dimensional reconstruction",
            "iliac bone flap"
        ],
        "authors": [
            {
                "name": "Li Jianwei",
                "org": "Department of Trauma Orthopedics,Nanfang Hospital,Guangzhou "
            },
            {
                "name": "Lei Lei",
                "org": "Health Center,Foshan ,Guangdong Province,China"
            },
            {
                "name": "Jin Dan",
                "org": "Department of Trauma Orthopedics,Nanfang Hospital,Guangzhou "
            },
            {
                "name": "Zhao Hui",
                "org": "Department of Trauma Orthopedics,Nanfang Hospital,Guangzhou "
            },
            {
                "name": "Hu Jijie",
                "org": "Department of Trauma Orthopedics,Nanfang Hospital,Guangzhou "
            },
            {
                "name": "Wang Gang",
                "org": "Department of Trauma Orthopedics,Nanfang Hospital,Guangzhou "
            },
            {
                "name": "Yu Bin",
                "org": "Department of Trauma Orthopedics,Nanfang Hospital,Guangzhou "
            }
        ],
        "venue": "Chinese Journal of Bone and Joint Surgery",
        "year": 2013
    },
    "HJKjZkzu": {
        "id": "HJKjZkzu",
        "title": "A systematic evaluation and meta analysis of surgical and nonsurgical treatment for patients with acute nondisplaced or minimally displaced scaphoid fractures",
        "abstract": "Objective To systematically evaluate the clinical efficacy and complications of surgical and nonsurgical treatment for patients with acute nondisplaced or minimally displaced scaphoid fractures.Methods Relevant literature on orthopedics was reviewed from Coehrane library,Cochrane database(2011),MEDLINE(January 1966 to October 2011),EMbase(June 1966 to October 2011),CBM(January 1979 to October 2011),PubMed(June 1966 to October 2011),Wanfang database and CQVIP database.Data of randomized controlled trials(RCTs) and quasi-randomized controlled trials(Quasi-RCTs) on treatment for acute nondisplaced or minimally displaced scaphoid fractures were collected.Metaanalysis was conducted by using the Cachrane Collaboration′s RevMan 5.1 software.Results Nine RCTs involving 559 patients were performed in the study.The meta analysis revealed that the surgical group had shorter time from surgery to going back to work[SMD=-2.06,95%CI(-3.46,-0.67),P=0.004],faster fracture recovery [SMD=-5.88,95%CI(-9.23,-2.54),P=0.0006],but the rate of osteoarthritis of the scaphotrapezial joint was higher than nonsurgical group[RR=3.72,95%CI(1.61,8.63),P=0.002].No significant differences were found between the two groups in terms of the grip strength,wrist motion,DASH-score and PRWE-score,and incidence rates of non-union and osteoar-thritis of the radiocarpal joint.Conclusion Compared with nonsurgical group,patients in the surgical group can go back to work earlier and recover faster after adult nondisplaced or minimally displaced scaphoid fractures,but the rate of osteoarthritis of the scaphotrapezial joint is higher.Owing to the limitations of the study,large-scale randomized controlled trials are required for more precise conclusions.",
        "keywords": [
            "fractures",
            "scaphoid",
            "cast immobilization",
            "internal fixation"
        ],
        "authors": [
            {
                "name": "CHEN Zhi-gang",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,"
            },
            {
                "name": "YU Bin",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,"
            },
            {
                "name": "ZHANG Kai-rui",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,"
            },
            {
                "name": "DAI Hai-fei",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,"
            },
            {
                "name": "CUI Zhuang",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,"
            },
            {
                "name": "XIONG Xiao-long",
                "org": "Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong,"
            }
        ],
        "venue": "Journal of Clinical Medicine in Practice",
        "year": 2012
    },
    "8GlUBKfM": {
        "id": "8GlUBKfM",
        "title": "A novel resorbable strontium-containing α-calcium sulfate hemihydrate bone substitute: a preparation and preliminary study.",
        "abstract": "Distraction osteogenesis after aggrieved bone segment resections is promising in the treatment of bone tumors and osteomyelitis. However, there is ambiguity with regard to the optimal choice of bone substitute, with biodegradability and excellent bone repair performance constituting key requirements. The purpose of this study was to develop a novel resorbable strontium-containing alpha-calcium sulfate hemihydrate (Sr-CaS) bone substitute to provide an alternative option for surgeons that better meets these requirements. The Sr-CaS was prepared using co-precipitation and hydrothermal methods and analyzed using x-ray diffraction (XRD), Fourier transform infrared (FTIR) scanning and thermogravimetric differential scanning calorimeter (TG-DSC) patterns. Cytotoxicity by tetrazolium bromide (MTT), sub-acute toxicity and hemolysis tests were performed to assess the initial biocompatibility of the new bone substitute. Radiographic analysis, micro-CT measurements and histological observation were used to evaluate the bone repair ability in rat tibia bone defects. The XRD and FTIR patterns of Sr-CaS were both very similar to CaS and the product had comparable characteristics similar to alpha-CaS as demonstrated by TG-DSC. Cytotoxicity of the substitute was class 1 (no cytotoxicity) and hemolysis was 4.3% (no hemolysis). Sub-acute toxicity was not seen after a 14 day evaluation. The substitute was radio-opaque. The empty group exhibited the lowest levels of both bone mineral densities (BMD) and bone volume/total volume (BV/TV) of the defects when compared to all other groups. The two Sr-CaS groups resulted in significantly greater BMDs and BV/TV of the defect compared to the CaS only group. However, there was no significant difference between the 5% and 10% Sr-CaS groups. The Sr-CaS was resorbable with satisfactory biocompatibility. The doped strontium ions enhanced the bone repair performance of CaS in a rat model and the new substitute demonstrated promising results for clinical use.",
        "keywords": [
            "strontium-containing alpha-calcium sulfate hemihydrate",
            "resorbable bone substitute biocompatibility",
            "bone repair"
        ],
        "authors": [
            {
                "name": "Xue Li",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Chang-peng Xu",
                "org": "Southern Med Univ, Nanfang Hosp, Key Lab Bone & Cartilage Regenerat Med, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Yi-long Hou",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Jin-qi Song",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Zhuang Cui",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Sheng-nan Wang",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Lei Huang",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Chang-ren Zhou",
                "org": "Jinan Univ, Coll Sci & Engn, Dept Mat Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            }
        ],
        "venue": "BIOMEDICAL MATERIALS",
        "year": 2014
    },
    "5JQ8Yzbm": {
        "id": "5JQ8Yzbm",
        "title": "InterTan nail versus Proximal Femoral Nail Antirotation-Asia in the treatment of unstable trochanteric fractures.",
        "abstract": "The goal of this study was to compare the outcomes of unstable trochanteric fractures treated with the InterTan nail (Smith & Nephew, Memphis, Tennessee) and the Proximal Femoral Nail Antirotation (PFNA-II) (Synthes, Solothurn, Switzerland). A total of 132 consecutive patients with unstable trochanteric fractures of the femur were enrolled in the study. The only intervention was InterTan nail or PFNA-II fixation of the unstable trochanteric fractures. Follow-up occurred at 1, 3, 6, and 12 months postoperatively and yearly thereafter. Radiographs were obtained at each follow-up, and all implant position changes, complications, and fixation failures were recorded. A total of 113 patients meeting the criteria were evaluated at a mean last follow-up of 18.36 months (range, 12-30 months). Intraoperative complications and length of hospital stay were comparable between the groups. Patients treated with the PFNA-II experienced shorter fluoroscopy and operative times, less intraoperative blood loss, and less femoral neck shortening. The incidence of thigh pain was significantly higher in the PFNA-II group (30.4%) than in the InterTan group (10.3%) (P=.001). No statistically significant differences existed in general complications, local complications, walking ability, Harris Hip Scores, or hip range of motion at final follow-up.",
        "keywords": [],
        "authors": [
            {
                "name": "Sheng Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Kairui Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yanfei Jia",
                "org": "Second Affiliated Hospital of Inner Mongolia Medical University(Second Affiliated Hospital of Inner Mongolia Medical University),,China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wei Feng",
                "org": "Second Affiliated Hospital of Inner Mongolia Medical University(Second Affiliated Hospital of Inner Mongolia Medical University),,China"
            }
        ],
        "venue": "Orthopedics",
        "year": 2013
    },
    "08Ud1S1g": {
        "id": "08Ud1S1g",
        "title": "Recombinant human bone morphogenetic protein-2 down-regulates LASP1 and up-regulates ferritin during osteogenic differentiation of beagle dog bone marrow mesenchymal stem cells]",
        "abstract": "Objective To identify the proteins involved in osteogenic differentiation of beagle dog bone marrow mesenchymal stem cells(BMSCs) and explore its possible regulation mechanism of osteogenic differentiation of BMSCs.Methods Cultured beagle dog BMSCs were induced by recombinant human bone morphogenetic protein-2(rhBMP-2) for 7 days.The differentially expressed proteins between cells with osteogenic differentiation and control cells were identified by proteomics analysis based on two-dimensional gel electrophoresis.Q-PCR and Western blotting were used to verify the interested protein of LASP1,ferritin light chain and heavy chain.Results Osteogenic differentiation was induced successfully in the BMSCs.Twenty differentially expressed proteins were identified by proteomic analysis,including 9 down-regulated and 11 upregulated ones.Q-PCR and Western blotting demonstrated a significant reduction of LASP1 expression and significant upregulation of ferritin in the BMSCs after a 7-day induction with rhBMP-2.Conclusion LASP1,which plays an important role in the regulation of the activity of the cytoskeleton,and ferritin,an important molecule in cellular iron homeostasis,can be critical in the osteogenic differentiation of beagle dog BMSCs induced by rhBMP-2.",
        "keywords": [
            "LASP1",
            "ferritin",
            "osteogenic differentiation",
            "recombinant human bone morphogenetic protein-2",
            "bone marrow mesenchymal stem cells"
        ],
        "authors": [
            {
                "name": "Jijie Hu",
                "org": "Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail: hjj0610@163.com."
            },
            {
                "name": "Yawei Liu",
                "org": ""
            },
            {
                "name": "Minyi He",
                "org": " Department of Organ Transplantation,Zhujiang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Bin Yu",
                "org": " 1 Department of Orthopedics and Traumatology,2 Department of Neurosurgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "Gang Wang",
                "org": " 1 Department of Orthopedics and Traumatology,2 Department of Neurosurgery,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2013
    },
    "1bvsjADg": {
        "id": "1bvsjADg",
        "title": "Eucommia ulmoides Oliv. bark aqueous extract inhibits osteoarthritis in a rat model of osteoarthritis.",
        "abstract": "Eucommia ulmoides Oliv. bark (EU) is a common traditional Chinese herbal medicine for treatment of osteoarthritis (OA), but its therapeutic effect on OA and the underlying mechanisms have not been fully clarified. Our previous study showed that Eucommia ulmoides Oliv. bark aqueous extract (EUE) had a protective effect on cartilage, and this study was aimed to investigate the anti-osteoarthritis effect and mechanisms of EUE in a rat model of osteoarthritis.Thirty-two 5-week-old specific pathogen-free Sprague-Dawley rats which were randomized into four even groups (n=8). Group A received sham operation while the OA model was established using the modified Hulth technique in groups B, C and D. For eight weeks after operation, in addition to routine feeding, group A received gavage with deionized water, group B with deionized water, group C with 1.35 g/kg/day EUE, and group D with 2.7 g/kg/day EUE. Eight weeks postoperatively, all of the animals were euthanized for radiological, gross and histopathological observations to evaluate the effect of EUE on OA and to determine its potential mechanisms.Radiological and histopathological observations showed that the articular degenerative changes were significantly more alleviated in groups C and D than in group B, while there were no obviously degenerative manifestations in group A. Mankin׳s scores in groups C and D were significantly lower than in group B (P<0.01). The severity of OA was significantly less in group D than in group C (P<0.01). The IL-1β and IL-6 contents in serum and MMP-3 secretion in articular cartilage were significantly lower in groups C and D than those in group B (P<0.01), and significantly lower in group D than those in group C (P<0.01). Compared with group B, phosphorylated Akt was significantly down-regulated in groups C and D.EUE may inhibit the progression of osteoarthritis by inhibiting the PI3K/Akt pathway to delay cartilage degeneration, reduce inflammatory cytokines and prevent MMP-3 secretion. Therefore, EU is a potential therapeutic agent for OA, but its efficacy is limited.",
        "keywords": [
            "eucommia ulmoides oliv. bark",
            "il-1β",
            "il-6",
            "mmp-3",
            "osteoarthritis",
            "pi3k/akt signaling pathway"
        ],
        "authors": [
            {
                "name": "Guo-ping Xie",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China; Key laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Nan Jiang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Sheng-nan Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Rui-zhen Qi",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Lei Wang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Pei-ran Zhao",
                "org": "Key laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Liang Liang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Southern Medical University, PR China; Key laboratory of Bone and Cartilage Regenerative Medicine of Guangdong Province, Nanfang Hospital, Southern Medical University, PR China."
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2015
    },
    "hoLJu5ej": {
        "id": "hoLJu5ej",
        "title": "Tissue Engineering and Regeneration of Large Segmental Femur Defects with Mesenchymal Stem Cells in Dual Fluorescent Chimeric Transgenic Mice",
        "abstract": "Purpose: The aim of this study was to establish a platform for future investigation of the mechanisms mediating the repair of tissue engineering bone (TEB) in a large segmental femur defect model. Methods: A large segmental femur defect (5 mm) model was developed by microsurgery in red fluorescent protein (RFP) transgenic mice. The defects were repaired with TEB in situ, composed of a beta-tricalcium phosphate scaffold and preseeded with mesenchymal stem cells (MSCs) derived from enhanced green fluorescent protein transgenic mice (eGFP-MSCs). X-ray analysis, pathological observation, and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) were used to examine the femur defects. Results: Three months postoperation, X-ray analysis revealed good prognoses in mice treated with TEB. Complete connection of the callus bone was observed by gross anatomy. Pathological observation showed recanalization of the bone marrow under confocal and fluorescent microscopy. Histological and qRT-PCR analyses showed that donor and recipient cells were actively involved in the bone repair process. Conclusions: We established a large segmental bone defect TEB repair model with dual fluorescent chimeric transgenic mice to serve as a platform for studying the mechanisms of TEB healing in vivo and provide a bases for further clinical applications.",
        "keywords": [
            "Tissue Engineering Bone",
            "Mesenchymal Stem Cell",
            "Dual Fluorescence"
        ],
        "authors": [
            {
                "name": "Shan Jiang",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Yang Lu",
                "org": "Southern Med Univ, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Bin Chen",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Xinxin Zhang",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Peiran Zhao",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Xiaorui Jiang",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Xiyu Cai",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Orthopaed & Traumatol, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Majar Jerry",
                "org": "Southern Med Univ, Guangzhou 510515, Guangdong, Peoples R China"
            },
            {
                "name": "Qianli Jiang",
                "org": "Southern Med Univ, Nanfang Hosp, Dept Hematol, Guangzhou 510515, Guangdong, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING",
        "year": 2017
    },
    "U8FkUEBr": {
        "id": "U8FkUEBr",
        "title": "Progress in treatment of acute achilles tendon rupture]",
        "abstract": "To review the progress in the treatment of acute Achilles tendon rupture.Recent literature about the treatment of acute Achilles tendon rupture was reviewed and analyzed.Treatments of acute Achilles tendon rupture include operative and non-operative treatments. Operative treatments include open surgery and percutaneous minimally invasive surgery. Compared with non-operative treatment, operative treatment can effectively reduce the re-rupture incidence, but it had higher complication incidences of wound infection and nerve injury. Although early functional rehabilitation during non-operative treatment could reduce the re-rutpture incidence, there is no consistent orthopaedic device and guideline for functional rehabilitation.Both operative and non-operative treatments have advantages and disadvantages for the treatment of acute Achilles tendon rupture. No consistent conclusion is arrived regarding functional recovery. Future studies should explore the strategy of early functional rehabilitation during non-operative treatment and its mechanism of promoting tendon healing.",
        "keywords": [
            "acute achilles tendon rupture non-operative treatment open surgery percutaneous minimally invasive surgery"
        ],
        "authors": [
            {
                "name": "Jiang Nan",
                "org": "cDepartment of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Dayong Xiang",
                "org": "cDepartment of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            },
            {
                "name": "Bin Yu",
                "org": "cDepartment of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou Guangdong,,P.R.China"
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2013
    },
    "lybPxEDJ": {
        "id": "lybPxEDJ",
        "title": "The measurement of three-dimensional anatomy of the proximal femoral medullary cavity",
        "abstract": "Objectives To study the morphologic features of the proximal femoral medullary cavity,and provide basis for the design and application of the domestic proximal femoral nail(PFNA).Methods The CT image data of 120 Chinese proximal femurs(male 55 cases,female 65 cases)were collected in this study.Three-dimensional anatomic parameters,including internal diameter of medullary cavity,and the canal flare index of the proximal femurs,were analyzed adopting mimics software,while,the correlations of the above parameters with the age,the height and the gender of patients were analyzed statistically.Results Using the mid-point of lesser trochanter as a reference,the internal diameter of medullary cavity were T+20(44.79±5.42) mm and(39.79±4.96) mm;T+10(34.00±3.64) mm and(32.06±3.29) mm;T(26.93±3.71)mm and(24.18±3.31) mm;T-20((18.65±2.96) mm and(18.21±2.60) mm for male and female respectively,as well as of the isthmic portion(10.40±1.45)mm and(10.15±1.05) mm respectively.There were significant difference of the above parameters between both sexes in T+20,T+10 and T states(P<0.05),on the contrary,no significance appeared in T-20 and isthmus states.All data were positively correlated with patients' height except for MCFI,which was negative correlated with the height.The internal diameter of the medullary cavity were positively correlated with patients' age(P<0.05),however,there were no correlation between the age and CFI,MCFI and DCFI.Conclusions The anatomic parameters of medullary cavity are variable for both sexes and different races,which implicates that,it is important to select the suitable fixation devices for treating different intertrochanteric fracture.",
        "keywords": [
            "Medullary cavity",
            "Three-dimension reconstruction",
            "Proximal femoral nail(PFNA)",
            "Proximal femur"
        ],
        "authors": [
            {
                "name": "ZHANG Sheng",
                "org": ",et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": ",et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LUO Ji-wei",
                "org": ",et al.Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Anatomy",
        "year": 2010
    },
    "kxOFrQCV": {
        "id": "kxOFrQCV",
        "title": "Clinical effects of free perforator flap on soft tissue defect of ankle",
        "abstract": "Background: The treatment of soft tissue defect of ankle is a challenge for orthopaedic surgeon, and skin flap transplantation has been indispensable. Objective: The aim of this study is to evaluate the surgical technique and clinical significance of the therapy for ankle soft tissue defect with two different free perforator flaps. Methods: Free perforator flap transplantations were performed in 30 patients with soft tissue defect and exposed bone of the ankle between August 2006 and April 2012. There were 24 males and 6 females aged from 3~52 years. The wounds were covered by vacuum sealing drainage (VSD) before operation. The size of the wound varied from 6 cm×8 cm to 11 cm×23 cm. Of them, 12 cases were repaired by thoraco-umbilical flap and 18 cases were repaired by anterolateral thigh flap. Results: All the 30 flaps survived. The mean duration of follow-up was 11.0 months (range, 3 to 24 months). The appear- ance of the flaps was satisfactory, with 10 to 22 mm in 2-PD. The sensation percentage beyond S2was 58.3% and 68.8% for thoraco-umbilical flap and anterolateral thigh flap transplantations, respectively. Conclusions: Both free anterolateral thigh perforator flap and free thoraco-umbilical perforator flap are suitable for the soft tissue defect of ankle. Perforator flap can decrease secondary orthopaedic surgery. VSD can significantly decrease the infec- tion of the perforator flaps.",
        "keywords": [
            "perforator flap",
            "soft tissue defect",
            "vacuum sealing drainage",
            "ankle"
        ],
        "authors": [
            {
                "name": "Hu Jijie",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Jin Dan",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Zhao Hui",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Ren Gaohong",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Wang Gang",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Yu Bin",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Li Jianwei",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            },
            {
                "name": "Liang Shuangwu",
                "org": "Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Bone and Joint Surgery",
        "year": 2012
    },
    "SA5fvTH8": {
        "id": "SA5fvTH8",
        "title": "Detection of daytime arctic clouds using MISR and MODIS data",
        "abstract": "Expert labels were used to evaluate arctic cloud detection accuracies of several methods based on MISR angular radiances and MODIS spectral radiances. The accuracy of cloud detections was evaluated relative to 5.086 million expert labels applied to 7.114 million 1.1-km resolution pixels with valid radiances from 57 scenes. The accuracy of the MODIS operational cloud mask was 90.72% for the 32 partly cloudy scenes and 93.37% for the 25 completely clear and overcast scenes. An automated, simple threshold algorithm based on three features extracted from MISR radiances and the MODIS operational cloud mask agreed with each other for 74.91% of the pixels in the 32 partly cloudy scenes and 78.44% of the pixels in the 25 completely clear and overcast scenes. These subsets of pixels had, relative to the expert labels, classification accuracies of 96.53% for the 32 partly cloudy scenes and 99.05% for the 25 completely clear and overcast scenes. Fisher's quadratic discriminate analysis (QDA) trained on expert labels from the 32 partly cloud scenes was applied to MISR radiances, three features based on MISR radiances, MODIS radiances, and the six features of the MODIS operational cloud mask with accuracies ranging from 87.51% to 96.43%. Accuracies increased to about 97% when QDA with expert labels was applied to combined radiances or features from both MISR and MODIS. Operational QDA-based classifiers were developed using as training labels those pixels for which the MISR automated, simple threshold and MODIS operational cloud mask algorithms agreed. Training the QDA classifier on these automatic labels using MISR radiances, three features based on MISR radiances, MODIS radiances, and the six features of the MODIS operational cloud mask led to accuracies ranging from 85.23% to 93.62% for the 32 partly cloudy scenes. Classification accuracies increased to 93.74% (93.40%) when combined MISR and MODIS radiances (features) were used. The highest accuracy attained with any operational algorithm tested on all 57 scenes was 94.51%. These results suggest that both MISR and MODIS radiances are sufficient for cloud detection in daytime polar regions.",
        "keywords": [
            "cloud detection",
            "polar study",
            "misr",
            "modis",
            "algorithms",
            "spectroradiometers",
            "feature extraction",
            "quadratic discriminant analysis",
            "experimental design"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Eugene E. Clothiaux",
                "org": "Department of Meteorology, Pennsylvania State University, University Park, PA 16802, United States"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720-3860, United States"
            },
            {
                "name": "Amy J. Braverman",
                "org": "Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109-8099, United States"
            },
            {
                "name": "David N. Groff",
                "org": "Department of Energy, Southern Great Plains Site, 309600 EW 28, Billings, OK 74630, United States"
            }
        ],
        "venue": "Remote Sensing of Environment",
        "year": 2007
    },
    "Ef45ZFbh": {
        "id": "Ef45ZFbh",
        "title": "Singularity, Misspecification, and the Convergence Rate of EM.",
        "abstract": "A line of recent work has characterized the behavior of the EM algorithm in favorable settings in which the population likelihood is locally strongly concave around its maximizing argument. Examples include suitably separated Gaussian mixture models and mixtures of linear regressions. We consider instead over-fitted settings in which the likelihood need not be strongly concave, or, equivalently, when the Fisher information matrix might be singular. In such settings, it is known that a global maximum of the MLE based on $n$ samples can have a non-standard $n^{-1/4}$ rate of convergence. How does the EM algorithm behave in such settings? Focusing on the simple setting of a two-component mixture fit to a multivariate Gaussian distribution, we study the behavior of the EM algorithm both when the mixture weights are different (unbalanced case), and are equal (balanced case). Our analysis reveals a sharp distinction between these cases: in the former, the EM algorithm converges geometrically to a point at Euclidean distance $O((d/n)^{1/2})$ from the true parameter, whereas in the latter case, the convergence rate is exponentially slower, and the fixed point has a much lower $O((d/n)^{1/4})$ accuracy. The slower convergence in the balanced over-fitted case arises from the singularity of the Fisher information matrix. Analysis of this singular case requires the introduction of some novel analysis techniques, in particular we make use of a careful form of localization in the associated empirical process, and develop a recursive argument to progressively sharpen the statistical rate.",
        "keywords": "",
        "authors": [
            {
                "name": "Raaz Dwivedi",
                "org": ""
            },
            {
                "name": "Nhat Ho",
                "org": ""
            },
            {
                "name": "Koulik Khamaru",
                "org": ""
            },
            {
                "name": "Michael I. Jordan",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Statistics Theory",
        "year": 2018
    },
    "EZnCulk3": {
        "id": "EZnCulk3",
        "title": "Superheat: An R Package for Creating Beautiful and Extendable Heatmaps for Visualizing Complex Data",
        "abstract": "The technological advancements of the modern era have enabled the collection of huge amounts of data in science and beyond. Extracting useful information from such massive datasets is an ongoing challenge as traditional data visualization tools typically do not scale well in high-dimensional settings. An existing visualization technique that is particularly well suited to visualizing large datasets is the heatmap. Although heatmaps are extremely popular in fields such as bioinformatics, they remain a severely underutilized visualization tool in modern data analysis. This paper introduces superheat, a new R package that provides an extremely flexible and customizable platform for visualizing complex datasets. Superheat produces attractive and extendable heatmaps to which the user can add a response variable as a scatterplot, model results as boxplots, correlation information as barplots, and more. The goal of this paper is two-fold: (1) to demonstrate the potential of the heatmap as a core visualization method for a range of data types, and (2) to highlight the customizability and ease of implementation of the superheat R package for creating beautiful and extendable heatmaps. The capabilities and fundamental applicability of the superheat package will be explored via three reproducible case studies, each based on publicly available data sources.",
        "keywords": [
            "Data Visualization",
            "Exploratory Data Analysis",
            "Heatmap",
            "Multivariate Data"
        ],
        "authors": [
            {
                "name": "Rebecca L Barter",
                "org": "Department of Statistics, UC Berkeley, Berkeley, CA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics and Department of Electrical Engineering and Computer Science, UC Berkeley, Berkeley, CA"
            }
        ],
        "venue": "Journal of Computational and Graphical Statistics",
        "year": 2018
    },
    "0ysm3avg": {
        "id": "0ysm3avg",
        "title": "Network Tomography: Recent Developments",
        "abstract": "Today's Internet is a massive, distributed network which continues to explode in size as e- commerce and related activities grow. The heterogeneous and largely unregulated structure of the Internet renders tasks such as dynamic routing, optimized service provision, service level verification, and detection of anomalous/malicious behavior extremely challenging. The problem is compounded by the fact that one cannot rely on the cooperation of individual servers and routers to aid in the collection of network traffic measurements vital for these tasks. In many ways, network monitoring and inference problems bear a strong resemblance to other \"inverse problems\" in which key aspects of a system are not directly observable. Familiar signal processing or statistical problems such as tomographic image reconstruction and phylogenetic tree identification have interesting connections to those arising in networking. This article introduces network tomography, a new field which we believe will benefit greatly from the wealth of statistical theory and algorithms. It focuses especially on recent developments in the field including the application of pseudolikelihood methods and tree estimation formulations.",
        "keywords": [
            "network tomography",
            "pseudo-likelihood",
            "tree estima- tion.",
            "topology identification",
            "dynamic routing",
            "phylogenetic tree",
            "inverse problem",
            "signal processing",
            "e commerce",
            "image reconstruction",
            "network monitoring",
            "service level"
        ],
        "authors": [
            {
                "name": "Rui Castro",
                "org": ""
            },
            {
                "name": "Mark Coates",
                "org": ""
            },
            {
                "name": "Gang Liang",
                "org": ""
            },
            {
                "name": "Robert Nowak",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Statistical Science",
        "year": 2004
    },
    "vGz2mwNG": {
        "id": "vGz2mwNG",
        "title": "Approximation lasso methods for language modeling",
        "abstract": "Lasso is a regularization method for parameter estimation in linear models. It optimizes the model parameters with respect to a loss function subject to model complexities. This paper explores the use of lasso for statistical language modeling for text input. Owing to the very large number of parameters, directly optimizing the penalized lasso loss function is impossible. Therefore, we investigate two approximation methods, the boosted lasso (BLasso) and the forward stagewise linear regression (FSLR). Both methods, when used with the exponential loss function, bear strong resemblance to the boosting algorithm which has been used as a discriminative training method for language modeling. Evaluations on the task of Japanese text input show that BLasso is able to produce the best approximation to the lasso solution, and leads to a significant improvement, in terms of character error rate, over boosting and the traditional maximum likelihood estimation.",
        "keywords": [
            "penalized lasso loss function",
            "lasso solution",
            "approximation lasso method",
            "exponential loss function",
            "best approximation",
            "linear model",
            "approximation method",
            "japanese text input show",
            "language modeling",
            "discriminative training method",
            "loss function subject",
            "maximum likelihood estimate",
            "linear regression",
            "language model",
            "loss function"
        ],
        "authors": [
            {
                "name": "Jianfeng Gao",
                "org": "One Microsoft Way, Redmond, WA"
            },
            {
                "name": "Hisami Suzuki",
                "org": "One Microsoft Way, Redmond, WA"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley, CA"
            }
        ],
        "venue": "ACL",
        "year": 2006
    },
    "XExbod1j": {
        "id": "XExbod1j",
        "title": "Vaidya walk: A sampling algorithm based on the volumetric barrier.",
        "abstract": "The problem of sampling from the uniform distribution over a polytope arises in various contexts. We propose a new random walk for this purpose, which we refer to as the Vaidya walk, since it is based on the volumetric-logarithmic barrier introduced by Vaidya in the context of interior point methods for optimization. We show that the Vaidya walk mixes in significantly fewer steps compared to the Dikin walk, a random walk previously studied by Kannan and Narayanan. In particular, we prove that for a polytope in R-d defined by n constraints, the Vaidya walk mixes in O (root n/d) fewer steps than the Dikin walk. The per iteration cost for our method is at most twice that of the Dikin walk, and hence the speed up is significant for polytopes with n >> d. Furthermore, the algorithm is also faster than the Ball walk and Hit-and-Run for a large family of polytopes. We illustrate the speed-up of the Vaidya walk over the Dikin walk via several numerical examples and discuss possible new and faster algorithms for sampling from polytopes.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuansi Chen",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "Raaz Dwivedi",
                "org": "Univ Calif Berkeley, Dept Elect Engn & Comp Sci, Berkeley, CA 94720 USA"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "Bin Yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "2017 55TH ANNUAL ALLERTON CONFERENCE ON COMMUNICATION, CONTROL, AND COMPUTING (ALLERTON)",
        "year": 2017
    },
    "sLi9Zjui": {
        "id": "sLi9Zjui",
        "title": "Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks",
        "abstract": "Spatial gene expression patterns enable the detection of local covariability and are extremely useful for identifying local gene interactions during normal development. The abundance of spatial expression data in recent years has led to the modeling and analysis of regulatory networks. The inherent complexity of such data makes it a challenge to extract biological information. We developed staNMF, a method that combines a scalable implementation of nonnegative matrix factorization (NMF) with a new stability-driven model selection criterion. When applied to a set of Drosophila early embryonic spatial gene expression images, one of the largest datasets of its kind, staNMF identified 21 principal patterns (PP). Providing a compact yet biologically interpretable representation of Drosophila expression patterns, PP are comparable to a fate map generated experimentally by laser ablation and show exceptional promise as a data-driven alternative to manual annotations. Our analysis mapped genes to cell-fate programs and assigned putative biological roles to uncharacterized genes. Finally, we used the PP to generate local transcription factor regulatory networks. Spatially local correlation networks were constructed for six PP that span along the embryonic anterior–posterior axis. Using a two-tail 5% cutoff on correlation, we reproduced 10 of the 11 links in the well-studied gap gene network. The performance of PP with the Drosophila data suggests that staNMF provides informative decompositions and constitutes a useful computational lens through which to extract biological insight from complex and often noisy gene expression data.",
        "keywords": [
            "principal patterns",
            "sparse decomposition",
            "spatial gene expression",
            "spatially local networks",
            "stability selection"
        ],
        "authors": [
            {
                "name": "Siqi Wu",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720;;Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"
            },
            {
                "name": "Antony Joseph",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720;;Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;;Walmart Labs, San Bruno, CA 94066;"
            },
            {
                "name": "Ann S. Hammonds",
                "org": "Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"
            },
            {
                "name": "Susan E. Celniker",
                "org": "Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720;;Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720"
            },
            {
                "name": "Erwin Frise",
                "org": "Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720;"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2016
    },
    "BrUVgfrW": {
        "id": "BrUVgfrW",
        "title": "Asymptotic distribution and sparsistency for l1-penalized parametric\n  M-estimators with applications to linear SVM and logistic regression",
        "abstract": "Since its early use in least squares regression problems, the l1-penalization\nframework for variable selection has been employed in conjunction with a wide\nrange of loss functions encompassing regression, classification and survival\nanalysis. While a well developed theory exists for the l1-penalized least\nsquares estimates, few results concern the behavior of l1-penalized estimates\nfor general loss functions. In this paper, we derive two results concerning\npenalized estimates for a wide array of penalty and loss functions. Our first\nresult characterizes the asymptotic distribution of penalized parametric\nM-estimators under mild conditions on the loss and penalty functions in the\nclassical setting (fixed-p-large-n). Our second result explicits necessary and\nsufficient generalized irrepresentability (GI) conditions for l1-penalized\nparametric M-estimates to consistently select the components of a model\n(sparsistency) as well as their sign (sign consistency). In general, the GI\nconditions depend on the Hessian of the risk function at the true value of the\nunknown parameter. Under Gaussian predictors, we obtain a set of conditions\nunder which the GI conditions can be re-expressed solely in terms of the second\nmoment of the predictors. We apply our theory to contrast l1-penalized SVM and\nlogistic regression classifiers and find conditions under which they have the\nsame behavior in terms of their model selection consistency (sparsistency and\nsign consistency). Finally, we provide simulation evidence for the theory based\non these classification examples.",
        "keywords": [
            "loss function",
            "penalty function",
            "least square",
            "logistic regression",
            "development theory",
            "asymptotic distribution",
            "variable selection",
            "survival analysis",
            "model selection"
        ],
        "authors": [
            {
                "name": "Guilherme V. Rocha",
                "org": ""
            },
            {
                "name": "Xing Wangyand Bin Yuz",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "qzFLypBS": {
        "id": "qzFLypBS",
        "title": "Estimation Stability with Cross Validation (ESCV)",
        "abstract": "  Cross-validation (CV) is often used to select the regularization parameter in high dimensional problems. However, when applied to the sparse modeling method Lasso, CV leads to models that are unstable in high-dimensions, and consequently not suited for reliable interpretation. In this paper, we propose a model-free criterion ESCV based on a new estimation stability (ES) metric and CV. Our proposed ESCV finds a locally ES-optimal model smaller than the CV choice so that the it fits the data and also enjoys estimation stability property. We demonstrate that ESCV is an effective alternative to CV at a similar easily parallelizable computational cost. In particular, we compare the two approaches with respect to several performance measures when applied to the Lasso on both simulated and real data sets. For dependent predictors common in practice, our main finding is that, ESCV cuts down false positive rates often by a large margin, while sacrificing little of true positive rates. ESCV usually outperforms CV in terms of parameter estimation while giving similar performance as CV in terms of prediction. For the two real data sets from neuroscience and cell biology, the models found by ESCV are less than half of the model sizes by CV. Judged based on subject knowledge, they are more plausible than those by CV as well. We also discuss some regularization parameter alignment issues that come up in both approaches. ",
        "keywords": [
            "parameter estimation",
            "lasso",
            "prediction",
            "model selection"
        ],
        "authors": [
            {
                "name": "chinghway lim",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Journal of Computational and Graphical Statistics",
        "year": 2015
    },
    "49CqFUwF": {
        "id": "49CqFUwF",
        "title": "Data spectroscopy: learning mixture models using eigenspaces of convolution operators",
        "abstract": "In this paper we develop a spectral framework for estimating mixture distributions, specifically Gaussian mixture models. In physics, spectroscopy is often used for the identification of substances through their spectrum. Treating a kernel function K(x, y) as \"light\" and the sampled data as \"substance\", the spectrum of their interaction (eigenvalues and eigenvectors of the kernel matrix K) unveils certain aspects of the underlying parametric distribution p, such as the parameters of a Gaussian mixture. Our approach extends the intuitions and analyses underlying the existing spectral techniques, such as spectral clustering and Kernel Principal Components Analysis (KPCA). We construct algorithms to estimate parameters of Gaussian mixture models, including the number of mixture components, their means and covariance matrices, which are important in many practical applications. We provide a theoretical framework and show encouraging experimental results.",
        "keywords": [
            "existing spectral technique",
            "data spectroscopy",
            "mixture component",
            "gaussian mixture model",
            "convolution operator",
            "kernel matrix k",
            "spectral framework",
            "spectral clustering",
            "gaussian mixture",
            "theoretical framework",
            "mixture distribution",
            "kernel function k",
            "spectrum",
            "unsupervised learning",
            "eigenvalues and eigenvectors",
            "kernel function",
            "mixture model",
            "density estimation"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": "Ohio State University"
            },
            {
                "name": "Mikhail Belkin",
                "org": "Ohio State University"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "ICML",
        "year": 2008
    },
    "r9kIRGOq": {
        "id": "r9kIRGOq",
        "title": "Multiple-kernel learning-based unmixing algorithm for estimation of cloud fractions with MODIS and CloudSat data",
        "abstract": "Detection of clouds in satellite-generated radiance images, including those from MODIS, is an important first step in many applications of these data. In this paper we apply spectral unmixing to this problem with the aim of estimating subpixel cloud fractions, as opposed to identification only of whether or not a pixel radiance contains cloud contributions. We formulate the spectral unmixing approach in terms of multiple-kernel learning (MKL). To this end we propose a MKL-based unmixing algorithm that drives a multiple-kernel description of cloud, enabling estimation of sub-pixel cloud fractions. This approach is based on supervised learning. We generate training and testing samples by using CloudSat and CALIPSO data to compute cloud fractions within individual MODIS pixels. Results of our study on limited data (1875 training and testing MODIS pixels along with their CloudSat and CALIPSO based sub-pixel cloud fractions) show that the proposed algorithm can effectively estimate sub-pixel MODIS cloud fraction and outperforms support vector machine (SVM) in terms of estimation performance.",
        "keywords": [
            "remote sensing",
            "cloud detection",
            "modis",
            "learning (artificial intelligence)",
            "spectral unmixing algorithm",
            "spectral unmixing",
            "mkl based unmixing algorithm",
            "multiple-kernel learning (mkl)",
            "multiple kernel learning",
            "clouds",
            "calipso data",
            "modis data",
            "geophysical image processing",
            "cloudsat data",
            "object detection",
            "spectral unmixing approach",
            "subpixel cloud fraction estimation",
            "satellite generated radiance images",
            "support vector machines",
            "kernel",
            "learning artificial intelligence",
            "estimation",
            "vectors"
        ],
        "authors": [
            {
                "name": "Yanfeng Gu",
                "org": ""
            },
            {
                "name": "Shizhe Wang",
                "org": ""
            },
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Yinghui Lu",
                "org": ""
            },
            {
                "name": "Eugene E. Clothiaux",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "IGARSS",
        "year": 2012
    },
    "75wYTgIo": {
        "id": "75wYTgIo",
        "title": "Optimal objective function in high-dimensional regression",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "derek bean",
                "org": ""
            },
            {
                "name": "peter j bickel",
                "org": ""
            },
            {
                "name": "noureddine el karoui",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "ReothpEF": {
        "id": "ReothpEF",
        "title": "Information in the nonstationary case",
        "abstract": "Information estimates such as the direct method of Strong, Koberle, de Ruyter van Steveninck, and Bialek (1998) sidestep the difficult problem of estimating the joint distribution of response and stimulus by instead estimating the difference between the marginal and conditional entropies of the response. While this is an effective estimation strategy, it tempts the practitioner to ignore the role of the stimulus and the meaning of mutual information. We show here that as the number of trials increases indefinitely, the direct (or plug-in) estimate of marginal entropy converges (with probability 1) to the entropy of the time-averaged conditional distribution of the response, and the direct estimate of the conditional entropy converges to the time-averaged entropy of the conditional distribution of the response. Under joint stationarity and ergodicity of the response and stimulus, the difference of these quantities converges to the mutual information. When the stimulus is deterministic or nonstationary the direct estimate of information no longer estimates mutual information, which is no longer meaningful, but it remains a measure of variability of the response distribution across time.",
        "keywords": [
            "information theory",
            "direct method",
            "nonlinear dynamics",
            "action potentials",
            "conditional entropy",
            "conditional distribution",
            "entropy",
            "mutual information"
        ],
        "authors": [
            {
                "name": "Vincent Q. Vu",
                "org": "university of california berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics|University of California , Berkeley"
            },
            {
                "name": "Robert E. Kass",
                "org": "Department of Statistics|Center for the Neural Basis of Cognition|Carnegie Mellon University"
            }
        ],
        "venue": "Clinical Orthopaedics and Related Research",
        "year": 2009
    },
    "KvcVhUvq": {
        "id": "KvcVhUvq",
        "title": "Three papers on boosting: an introduction",
        "abstract": "",
        "keywords": [
            "machine learning",
            "numerical method"
        ],
        "authors": [
            {
                "name": "vladimir koltchinskii",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2004
    },
    "jkKVPiaY": {
        "id": "jkKVPiaY",
        "title": "Adjusting treatment effect estimates by post-stratification in randomized experiments: Adjusting Treatment Effect Estimates",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "luke miratrix",
                "org": ""
            },
            {
                "name": "jasjeet s sekhon",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Journal of The Royal Statistical Society Series B-statistical Methodology",
        "year": 2012
    },
    "qUmcfEdm": {
        "id": "qUmcfEdm",
        "title": "Co-clustering for directed graphs: the Stochastic co-Blockmodel and spectral algorithm Di-Sim",
        "abstract": "  Directed graphs have asymmetric connections, yet the current graph clustering methodologies cannot identify the potentially global structure of these asymmetries. We give a spectral algorithm called di-sim that builds on a dual measure of similarity that correspond to how a node (i) sends and (ii) receives edges. Using di-sim, we analyze the global asymmetries in the networks of Enron emails, political blogs, and the c elegans neural connectome. In each example, a small subset of nodes have persistent asymmetries; these nodes send edges with one cluster, but receive edges with another cluster. Previous approaches would have assigned these asymmetric nodes to only one cluster, failing to identify their sending/receiving asymmetries. Regularization and \"projection\" are two steps of di-sim that are essential for spectral clustering algorithms to work in practice. The theoretical results show that these steps make the algorithm weakly consistent under the degree corrected Stochastic co-Blockmodel, a model that generalizes the Stochastic Blockmodel to allow for both (i) degree heterogeneity and (ii) the global asymmetries that we intend to detect. The theoretical results make no assumptions on the smallest degree nodes. Instead, the theorem requires that the average degree grows sufficiently fast and that the weak consistency only applies to the subset of the nodes with sufficiently large leverage scores. The results results also apply to bipartite graphs. ",
        "keywords": [],
        "authors": [
            {
                "name": "karl rohe",
                "org": ""
            },
            {
                "name": "tai qin",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "4Agmkk8B": {
        "id": "4Agmkk8B",
        "title": "Definitions, methods, and applications in interpretable machine learning.",
        "abstract": "Machine-learning models have demonstrated great success in learning complex patterns that enable them to make predictions about unobserved data. In addition to using models for prediction, the ability to interpret what a model has learned is receiving an increasing amount of attention. However, this increased focus has led to considerable confusion about the notion of interpretability. In particular, it is unclear how the wide array of proposed interpretation methods are related and what common concepts can be used to evaluate them. We aim to address these concerns by defining interpretability in the context of machine learning and introducing the predictive, descriptive, relevant (PDR) framework for discussing interpretations. The PDR framework provides 3 overarching desiderata for evaluation: predictive accuracy, descriptive accuracy, and relevancy, with relevancy judged relative to a human audience. Moreover, to help manage the deluge of interpretation methods, we introduce a categorization of existing techniques into model-based and post hoc categories, with subgroups including sparsity, modularity, and simulatability. To demonstrate how practitioners can use the PDR framework to evaluate and understand interpretations, we provide numerous real-world examples. These examples highlight the often underappreciated role played by human audiences in discussions of interpretability. Finally, based on our framework, we discuss limitations of existing methods and directions for future work. We hope that this work will provide a common vocabulary that will make it easier for both practitioners and researchers to discuss and choose from the full range of interpretation methods.",
        "keywords": [
            "explainability",
            "interpretability",
            "machine learning",
            "relevancy"
        ],
        "authors": [
            {
                "name": "W James Murdoch",
                "org": "Statistics Department, University of California, Berkeley, CA 94720."
            },
            {
                "name": "Chandan Singh",
                "org": "Electrical Engineering and Computer Science Department, University of California, Berkeley, CA 94720."
            },
            {
                "name": "Karl Kumbier",
                "org": "Statistics Department, University of California, Berkeley, CA 94720."
            },
            {
                "name": "Reza Abbasi-Asl",
                "org": "Allen Institute for Brain Science, Seattle, WA 98109."
            },
            {
                "name": "Bin Yu",
                "org": "Electrical Engineering and Computer Science Department, University of California, Berkeley, CA 94720."
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2019
    },
    "VOnm4Qwy": {
        "id": "VOnm4Qwy",
        "title": "Comment: Monitoring Networked Applications With Incremental Quantile Estimation",
        "abstract": "Comment: Monitoring Networked Applications With Incremental Quantile\nEstimation [arXiv:0708.0302]",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "STATISTICAL SCIENCE",
        "year": 2006
    },
    "DPxqygRs": {
        "id": "DPxqygRs",
        "title": "Minimax rates of convergence for high-dimensional regression under ℓ q -ball sparsity",
        "abstract": "Consider the standard linear regression model y = X beta* + w, where y is an element of R-n is an observation vector, X is an element of R-nxd is a measurement matrix, beta* is an element of R-d is the unknown regression vector, and w similar to N(0, sigma I-2) is additive Gaussian noise. This paper determines sharp minimax rates of convergence for estimation of beta* in l(2) norm, assuming that beta* belongs to a weak l(q)-ball B-q (R-q) for some q is an element of [0, 1]. We show that under suitable regularity conditions on the design matrix X, the minimax error in squared l(2)-norm scales as R-q(logd/n)(1-q/2). In addition, we provide lower bounds on rates of convergence for general l(p) norm (for all p is an element of [1, + infinity], p not equal q). Our proofs of the lower bounds are information-theoretic in nature, based on Fano's inequality and results on the metric entropy of the balls B-q (R-q). Matching upper bounds are derived by direct analysis of the solution to an optimization algorithm over We prove that the conditions on X required by optimal algorithms are satisfied with high probability by broad classes of non-i.i.d. Gaussian random matrices, for which RIP or other sparse eigenvalue conditions are violated. For q = 0, l(1)-based methods (Lasso and Dantzig selector) achieve the minimax optimal rates in l(2) error, but require stronger regularity conditions on the design than the non-convex optimization algorithm used to determine the minimax upper bounds.",
        "keywords": [
            "covariance matrix",
            "noise",
            "regression analysis",
            "sparse matrices",
            "random matrices",
            "gaussian noise",
            "information theory",
            "design matrix",
            "convergence",
            "rate of convergence",
            "random processes",
            "eigenvalues",
            "upper bound",
            "linear regression model",
            "rip",
            "lower bound",
            "satisfiability",
            "vectors",
            "probability",
            "algorithm design and analysis"
        ],
        "authors": [
            {
                "name": "garvesh raskutti",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "martin j wainwright",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "bin yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "2009 47TH ANNUAL ALLERTON CONFERENCE ON COMMUNICATION, CONTROL, AND COMPUTING, VOLS 1 AND 2",
        "year": 2009
    },
    "x6rORWhF": {
        "id": "x6rORWhF",
        "title": "Stagewise Lasso",
        "abstract": "Many statistical machine learning algorithms minimize either an empirical loss function as in AdaBoost, or a penalized empirical loss as in Lasso or SVM. A single regularization tuning parameter controls the trade-off between fidelity to the data and generalizability, or equivalently between bias and variance. When this tuning parameter changes, a regularization \"path\" of solutions to the minimization problem is generated, and the whole path is needed to select a tuning parameter to optimize the prediction or interpretation performance. Algorithms such as homotopy-Lasso or LARS-Lasso and Forward Stagewise Fitting (FSF) (aka e-Boosting) are of great interest because of their resulted sparse models for interpretation in addition to prediction. In this paper, we propose the BLasso algorithm that ties the FSF (e-Boosting) algorithm with the Lasso method that minimizes the L1 penalized L2 loss. BLasso is derived as a coordinate descent method with a fixed stepsize applied to the general Lasso loss function (L1 penalized convex loss). It consists of both a forward step and a backward step. The forward step is similar to e-Boosting or FSF, but the backward step is new and revises the FSF (or e-Boosting) path to approximate the Lasso path. In the cases of a finite number of base learners and a bounded Hessian of the loss function, the BLasso path is shown to converge to the Lasso path when the stepsize goes to zero. For cases with a larger number of base learners than the sample size and when the true model is sparse, our simulations indicate that the BLasso model estimates are sparser than those from FSF with comparable or slightly better prediction performance, and that the the discrete stepsize of BLasso and FSF has an additional regularization effect in terms of prediction and sparsity. Moreover, we introduce the Generalized BLasso algorithm to minimize a general convex loss penalized by a general convex function. Since the (Generalized) BLasso relies only on differences not derivatives, we conclude that it provides a class of simple and easy-to-implement algorithms for tracing the regularization or solution paths of penalized minimization problems.",
        "keywords": [
            "BLasso algorithm",
            "L2 loss",
            "Stagewise Lasso",
            "Generalized BLasso algorithm",
            "forward step",
            "L1 penalized convex loss",
            "BLasso model estimate",
            "Lasso path",
            "empirical loss function",
            "BLasso path",
            "base learner"
        ],
        "authors": [
            {
                "name": "Peng Zhao",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2007
    },
    "Ltow3at5": {
        "id": "Ltow3at5",
        "title": "Spectral clustering and the high-dimensional Stochastic Block Model",
        "abstract": "Networks or graphs can easily represent a diverse set of data sources that\nare characterized by interacting units or actors. Social networks, representing\npeople who communicate with each other, are one example. Communities or\nclusters of highly connected actors form an essential feature in the structure\nof several empirical networks. Spectral clustering is a popular and\ncomputationally feasible method to discover these communities. The Stochastic\nBlock Model (Holland et al., 1983) is a social network model with well defined\ncommunities; each node is a member of one community. For a network generated\nfrom the Stochastic Block Model, we bound the number of nodes \"misclustered\" by\nspectral clustering. The asymptotic results in this paper are the first\nclustering results that allow the number of clusters in the model to grow with\nthe number of nodes, hence the name high-dimensional. In order to study\nspectral clustering under the Stochastic Block Model, we first show that under\nthe more general latent space model, the eigenvectors of the normalized graph\nLaplacian asymptotically converge to the eigenvectors of a \"population\"\nnormalized graph Laplacian. Aside from the implication for spectral clustering,\nthis provides insight into a graph visualization technique. Our method of\nstudying the eigenvectors of random matrices is original.",
        "keywords": [
            "convergence of eigenvectors",
            "principal components analysis. � the authors are grateful to michael mahoney and benjamin olding for their stimulating discussions.",
            "latent space model",
            "and phrases: spectral clustering",
            "stochastic block model",
            "clustering"
        ],
        "authors": [
            {
                "name": "Karl Rohe",
                "org": "Department of Statistics|University of California Berkeley"
            },
            {
                "name": "Sourav Chatterjee",
                "org": "Department of Statistics|University of California Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics|University of California Berkeley"
            }
        ],
        "venue": "",
        "year": 2010
    },
    "2e0Dorq0": {
        "id": "2e0Dorq0",
        "title": "Metalearners for estimating heterogeneous treatment effects using machine learning.",
        "abstract": "There is growing interest in estimating and analyzing heterogeneous treatment effects in experimental and observational studies. We describe a number of metaalgorithms that can take advantage of any supervised learning or regression method in machine learning and statistics to estimate the conditional average treatment effect (CATE) function. Metaalgorithms build on base algorithms-such as random forests (RFs), Bayesian additive regression trees (BARTs), or neural networks-to estimate the CATE, a function that the base algorithms are not designed to estimate directly. We introduce a metaalgorithm, the X-learner, that is provably efficient when the number of units in one treatment group is much larger than in the other and can exploit structural properties of the CATE function. For example, if the CATE function is linear and the response functions in treatment and control are Lipschitz-continuous, the X-learner can still achieve the parametric rate under regularity conditions. We then introduce versions of the X-learner that use RF and BART as base learners. In extensive simulation studies, the X-learner performs favorably, although none of the metalearners is uniformly the best. In two persuasion field experiments from political science, we demonstrate how our X-learner can be used to target treatment regimes and to shed light on underlying mechanisms. A software package is provided that implements our methods.",
        "keywords": [
            "conditional average treatment effect",
            "heterogeneous treatment effects",
            "minimax optimality",
            "observational studies",
            "randomized controlled trials"
        ],
        "authors": [
            {
                "name": "Sören R Künzel",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720; srk@berkeley.edu binyu@stat.berkeley.edu."
            },
            {
                "name": "Jasjeet S Sekhon",
                "org": "Department of Political Science, University of California, Berkeley, CA 94720."
            },
            {
                "name": "Peter J Bickel",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720."
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2019
    },
    "0fuckp4w": {
        "id": "0fuckp4w",
        "title": "Iterative random forests to discover predictive and stable high-order interactions.",
        "abstract": "Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome-wide binding sites for proteins, and many other molecular processes. However, individual genomic assays measure elements that interact in vivo as components of larger molecular machines. Understanding how these high-order interactions drive gene expression presents a substantial statistical challenge. Building on random forests (RFs) and random intersection trees (RITs) and through extensive, biologically inspired simulations, we developed the iterative random forest algorithm (iRF). iRF trains a feature-weighted ensemble of decision trees to detect stable, high-order interactions with the same order of computational cost as the RF. We demonstrate the utility of iRF for high-order interaction discovery in two prediction problems: enhancer activity in the early  embryo and alternative splicing of primary transcripts in human-derived cell lines. In , among the 20 pairwise transcription factor interactions iRF identifies as stable (returned in more than half of bootstrap replicates), 80% have been previously reported as physical interactions. Moreover, third-order interactions, e.g., between  (),  (), and  (), suggest high-order relationships that are candidates for follow-up experiments. In human-derived cells, iRF rediscovered a central role of H3K36me3 in chromatin-mediated splicing regulation and identified interesting fifth- and sixth-order interactions, indicative of multivalent nucleosomes with specific roles in splicing regulation. By decoupling the order of interactions from the computational cost of identification, iRF opens additional avenues of inquiry into the molecular mechanisms underlying genome biology.",
        "keywords": [
            "genomics",
            "high-order interaction",
            "interpretable machine learning",
            "random forests",
            "stability"
        ],
        "authors": [
            {
                "name": "Sumanta Basu",
                "org": "Data Driven Decisions Department, Preminon LLC, Antioch, CA 94531."
            },
            {
                "name": "Karl Kumbier",
                "org": "Statistics Department, University of California, Berkeley, CA 94720."
            },
            {
                "name": "James B Brown",
                "org": "Molecular Ecosystems Biology Department, Biosciences Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720."
            },
            {
                "name": "Bin Yu",
                "org": "Molecular Ecosystems Biology Department, Biosciences Area, Lawrence Berkeley National Laboratory, Berkeley, CA 94720."
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2018
    },
    "J3wKTXoC": {
        "id": "J3wKTXoC",
        "title": "Beyond Word Importance: Contextual Decomposition to Extract Interactions from LSTMs.",
        "abstract": "The driving force behind the recent success of LSTMs has been their ability to learn complex and non-linear relationships. Consequently, our inability to describe these relationships has led to LSTMs being characterized as black boxes. To this end, we introduce contextual decomposition (CD), an interpretation algorithm for analysing individual predictions made by standard LSTMs, without any changes to the underlying model. By decomposing the output of a LSTM, CD captures the contributions of combinations of words or variables to the final prediction of an LSTM. On the task of sentiment analysis with the Yelp and SST data sets, we show that CD is able to reliably identify words and phrases of contrasting sentiment, and how they are combined to yield the LSTMu0027s final prediction. Using the phrase-level labels in SST, we also demonstrate that CD is able to successfully extract positive and negative negations from an LSTM, something which has not previously been done.",
        "keywords": "",
        "authors": [
            {
                "name": "W. James Murdoch",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Peter J. Liu",
                "org": "Google"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "ICLR",
        "year": 2018
    },
    "Ra3fkC5t": {
        "id": "Ra3fkC5t",
        "title": "A hierarchical Bayesian approach for aerosol retrieval using MISR data",
        "abstract": "Atmospheric aerosols can cause serious damage to human health and reduce life expectancy. Using the radiances observed by NASA's Multi-angle Imaging SpectroRadiometer (MISR), the current MISR operational algorithm retrieves aerosol optical depth (AOD) at 17.6 km resolution. A systematic study of aerosols and their impact on public health, especially in highly populated urban areas, requires finerresolution estimates ofAOD's spatial distribution.We embedMISR's operationalweighted least squares criterion and its forward calculations for AOD retrievals in a likelihood framework and further expand into a hierarchical Bayesian model to adapt to finer spatial resolution of 4.4 km. To take advantage of AOD's spatial smoothness, our method borrows strength from data at neighboring areas by postulating a Gaussian Markov random field prior for AOD. Our model considers AOD and aerosol mixing vectors as continuous variables, whose inference is carried out using Metropolis-within-Gibbs sampling methods. Retrieval uncertainties are quantified by posterior variabilities. We also develop a parallel Markov chain Monte Carlo (MCMC) algorithm to improve computational efficiency. We assess our retrieval performance using ground-based measurements from the AErosol RObotic NETwork (AERONET) and satellite images from Google Earth. Based on case studies in the greater Beijing area, China, we show that 4.4 km resolution can improve both the accuracy and coverage of remotely sensed aerosol retrievals, as well as our understanding of the spatial and seasonal behaviors of aerosols. This is particularly important during high-AOD events, which often indicate severe air pollution. © 2013 American Statistical Association.",
        "keywords": [
            "fine retrieval resolution",
            "hierarchical bayesian model",
            "mcmc",
            "remote sensing",
            "spatial dependence",
            "spatial scale",
            "aerosol optical depth",
            "spatial resolution",
            "bayesian hierarchical model",
            "bayesian approach",
            "life expectancy",
            "gibbs sampling",
            "public health",
            "seasonality",
            "air pollution"
        ],
        "authors": [
            {
                "name": "Yueqing Wang",
                "org": "UC Berkeley(University of California),Berkeley,United States"
            },
            {
                "name": "Xin Jiang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "UC Berkeley(University of California),Berkeley,United States"
            },
            {
                "name": "Ming Jiang",
                "org": "Beijing International Center for Mathematical Research(Beijing International Center for Mathematical Research),Beijing,China"
            }
        ],
        "venue": "Journal of the American Statistical Association",
        "year": 2013
    },
    "NrZu8dhM": {
        "id": "NrZu8dhM",
        "title": "Model Selection in Gaussian Graphical Models: High-Dimensional Consistency of \\boldmath$\\ell_1$-regularized MLE",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "garvesh raskutti",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "martin j wainwright",
                "org": ""
            },
            {
                "name": "pradeep ravikumar",
                "org": ""
            }
        ],
        "venue": "neural information processing systems",
        "year": 2009
    },
    "hDVa2E41": {
        "id": "hDVa2E41",
        "title": "Statistical guarantees for the EM algorithm: From population to sample-based analysis",
        "abstract": "The EM algorithm is a widely used tool in maximum-likelihood estimation in incomplete data problems. Existing theoretical work has focused on conditions under which the iterates or likelihood values converge, and the associated rates of convergence. Such guarantees do not distinguish whether the ultimate fixed point is a near global optimum or a bad local optimum of the sample likelihood, nor do they relate the obtained fixed point to the global optima of the idealized population likelihood (obtained in the limit of infinite data). This paper develops a theoretical framework for quantifying when and how quickly EM-type iterates converge to a small neighborhood of a given global optimum of the population likelihood. For correctly specified models, such a characterization yields rigorous guarantees on the performance of certain two-stage estimators in which a suitable initial pilot estimator is refined with iterations of the EM algorithm. Our analysis is divided into two parts: a treatment of the EM and first-order EM algorithms at the population level, followed by results that apply to these algorithms on a finite set of samples. Our conditions allow for a characterization of the region of convergence of EM-type iterates to a given population fixed point, that is, the region of the parameter space over which convergence is guaranteed to a point within a small neighborhood of the specified population fixed point. We verify our conditions and give tight characterizations of the region of convergence for three canonical problems of interest: symmetric mixture of two Gaussians, symmetric mixture of two regressions and linear regression with covariates missing completely at random.",
        "keywords": [
            "EM algorithm",
            "first-order EM algorithm",
            "nonconvex optimization",
            "maximum likelihood estimation"
        ],
        "authors": [
            {
                "name": "Sivaraman Balakrishnan",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "Bin Yu 0001",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2017
    },
    "UVilyvne": {
        "id": "UVilyvne",
        "title": "The lasso under poisson-like heteroscedasticity",
        "abstract": "The performance of the Lasso is well understood under the assumptions of the standard sparse linear model with homoscedastic noise. However, in several applications, the standard model does not describe the important features of the data. This paper examines how the Lasso performs on a non-standard model that is motivated by medical imaging applications. In these applications, the variance of the noise scales linearly with the expectation of the observation. Like all heteroscedastic models, the noise terms in this Poisson-like model are not independent of the design matrix. Under a sparse Poisson-like model for the high-dimension regime that allows the number of predictors (p) ≫ sample size (n), we give necessary and sufficient conditions for the sign consistency of the Lasso estimate. Simulations reveal that the Lasso performs equally well in terms of model selection performance on both Poisson-like data and homoscedastic data (with properly scaled noise variance), across a range of parameterizations.",
        "keywords": [
            "heteroscedasticity",
            "lasso",
            "poisson-like model",
            "sign consistency"
        ],
        "authors": [
            {
                "name": "Jinzhu Jia",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Karl Rohe",
                "org": "University of Wisconsin Madison(University of Wisconsin-Madison),Madison,United States"
            },
            {
                "name": "Bin Yu",
                "org": "UC Berkeley(University of California),Berkeley,United States"
            }
        ],
        "venue": "Statistica Sinica",
        "year": 2013
    },
    "6Bqn1hH6": {
        "id": "6Bqn1hH6",
        "title": "Some statistical issues in estimating information in neural spike trains",
        "abstract": "Information theory provides an attractive framework for attacking the neural coding problem. This entails estimating information theoretic quantities from neural spike train data. This paper highlights two issues that may arise: non-parametric entropy estimation and non-stationarity. It gives an overview of these issues and some of the progress that has been made.",
        "keywords": [
            "information theoretic quantity",
            "statistical issue",
            "attractive framework",
            "neural spike train data",
            "information theory",
            "neural coding problem",
            "non-parametric entropy estimation",
            "entropy",
            "signal generators",
            "estimation",
            "mutual information",
            "statistics",
            "neurophysiology",
            "estimation theory",
            "entropy estimation",
            "maximum likelihood estimation",
            "channel coding",
            "data mining",
            "nervous system",
            "neural code",
            "cognition",
            "encoding"
        ],
        "authors": [
            {
                "name": "Vincent Q. Vu",
                "org": "University of California, Berkeley, Department of Statistics, USA"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley, Department of Statistics, USA"
            },
            {
                "name": "Robert E. Kass",
                "org": "Carnegie Mellon University, Department of Statistics, Center for the Neural Basis of Cognition, USA"
            }
        ],
        "venue": "ICASSP",
        "year": 2009
    },
    "CcJG2ulB": {
        "id": "CcJG2ulB",
        "title": "THE COMPOSITE ABSOLUTE PENALTIES FAMILY FOR GROUPED AND HIERARCHICAL VARIABLE SELECTION1",
        "abstract": "Extracting useful information from high-dimensional data is an important focus of today's statistical research and practice. Penalized loss function minimization has been shown to be effective for this task both theoretically and empirically. With the virtues of both regularization and sparsity, the L-1-penalized squared error minimization method Lasso has been popular in regression models and beyond. In this paper, we combine different norms including L-1 to form an intelligent penalty in order to add side information to the fitting of a regression or classification model to obtain reasonable estimates. Specifically, we introduce the Composite Absolute Penalties (CAP) family, which allows given grouping and hierarchical relationships between the predictors to be expressed. CAP penalties are built by defining groups and combining the properties of norm penalties at the across-group and within-group levels. Grouped selection occurs for nonoverlapping groups. Hierarchical variable selection is reached by defining groups with particular overlapping patterns. We propose using the BLASSO and cross-validation to compute CAP estimates in general. For a subfamily of CAP estimates involving only the L-1 and L-proportional to norms, we introduce the iCAP algorithm to trace the entire regularization path for the grouped selection problem. Within this subfamily, unbiased estimates of the degrees of freedom (df) are derived so that the regularization parameter is selected without cross-validation. CAP is shown to improve on the predictive performance of the LASSO in a series of simulated experiments, including cases with p >> n and possibly mis-specified groupings. When the complexity of a model is properly calculated, iCAP is seen to be parsimonious in the experiments.",
        "keywords": [
            "Linear regression",
            "penalized regression",
            "variable selection",
            "coefficient paths",
            "grouped selection",
            "hierarchical models"
        ],
        "authors": [
            {
                "name": "PENG ZHAO",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "G UILHERME ROCHA",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "BIN YU",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2009
    },
    "RCyhoG63": {
        "id": "RCyhoG63",
        "title": "Summarizing large-scale, multiple-document news data: sparse methods and human validation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinzhu jia",
                "org": ""
            },
            {
                "name": "luke miratrix",
                "org": ""
            },
            {
                "name": "brian gawalt",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "laurent el ghaoui",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "VYrLQ2Lz": {
        "id": "VYrLQ2Lz",
        "title": "Maximum pseudo likelihood estimation in network tomography",
        "abstract": "Network monitoring and diagnosis are key to improving network performance. The difficulties of performance monitoring lie in today's fast growing Internet, accompanied by increasingly heterogeneous and unregulated structures. Moreover, these tasks become even harder since one cannot rely on the collaboration of individual routers and servers to measure network traffic directly. Even though the aggregative nature of possible network measurements gives rise to inverse problems, existing methods for solving inverse problems are usually computationally intractable or statistically inefficient. A pseudo likelihood approach is proposed to solve a group of network tomography problems. The basic idea of pseudo likelihood is to form simple subproblems and ignore the dependences among the subproblems to form a product likelihood of the subproblems. As a result, this approach keeps a good balance between the computational complexity and the statistical efficiency of the parameter estimation. Some statistical properties of the pseudo likelihood estimator, such as consistency and asymptotic normality, are established. A pseudo expectation-maximization (EM) algorithm is developed to maximize the pseudo log-likelihood function. Two examples, with simulated or real data, are used to illustrate the pseudo likelihood proposal: 1) inference of the internal link delay distributions through multicast end-to-end measurements; 2) origin-destination matrix estimation through link traffic counts.",
        "keywords": [
            "pseudo likelihood proposal",
            "optimisation",
            "multicast tree",
            "index terms— end-to-end measurement",
            "link delay distribution",
            "network tomography problem",
            "statistical efficiency",
            "network traffic",
            "tomography",
            "pseudo likelihood approach",
            "network performance",
            "pseudo log-likelihood function",
            "monitoring",
            "parameter estimation",
            "statistical analysis",
            "maximum likelihood estimation",
            "pseudo likelihood.",
            "origin-destination matrix",
            "telecommunication traffic recording",
            "matrix algebra",
            "network diagnosis",
            "multicast end-to-end measurements",
            "network topology",
            "pseudo expectation-maximization",
            "pseudo likelihood",
            "inverse problems",
            "delays",
            "net- work tomography",
            "computational complexity",
            "network monitoring",
            "fault diagnosis",
            "inverse problem",
            "origin-destination matrix estimation",
            "internet",
            "link traffic",
            "maximum pseudo likelihood estimation",
            "network tomography",
            "internet topology",
            "pseudo expectation-maximization algorithm",
            "pseudo likelihood estimator",
            "multicast communication",
            "expectation maximization",
            "indexing terms",
            "likelihood function",
            "em algorithm"
        ],
        "authors": [
            {
                "name": "Gang Liang",
                "org": "Dept. of Stat., California Univ., Berkeley, CA, USA"
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Signal Processing",
        "year": 2003
    },
    "pg4Tx1r3": {
        "id": "pg4Tx1r3",
        "title": "Nonparametric sparse hierarchical models describe V1 fMRI responses to natural images",
        "abstract": "",
        "keywords": [
            "hierarchical model"
        ],
        "authors": [
            {
                "name": "vincent q vu",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "thomas naselaris",
                "org": ""
            },
            {
                "name": "kendrick n kay",
                "org": ""
            },
            {
                "name": "jack l gallant",
                "org": ""
            },
            {
                "name": "pradeep ravikumar",
                "org": ""
            }
        ],
        "venue": "neural information processing systems",
        "year": 2009
    },
    "P6ZdZBm3": {
        "id": "P6ZdZBm3",
        "title": "Sparsity and model selection through convex penalties: structured selection, covariance selection and some theory",
        "abstract": "High-dimensional data sets requires model selection methods capable of controlling model complexity and goodness of fit to the observed data. Such problems constitute a natural setting where to apply penalized empirical risk minimization. Ideally, a model should be interpretable and easy to compute. Sparsity in a parameter space is a proxy for interpretability and is traditionally enforced in statistics by penalizing the dimensionality of the parameter space. Such penalties lead to interpretable models but involve a combinatorial search and are thus computationally costly to obtain, obtained by penalizing the &ell; 1-norm of the fitted parameters. In the first article of this thesis, we present a simulation based comparison of two traditional approaches to tackle the computational burden of dimensionality based penalties: the more traditional greedy algorithms and the more recent convex relaxation methods. We conclude that convex relaxation yields estimates that are better in terms of predictive performance and comparable in terms of parameter selection provided the appropriate criterion is used for each application. Then, we introduce the family of Composite Absolute Penalties (CAP). Penalty functions in this family are capable of performing grouped and hierarchical selection. Building upon convexity of CAP penalties, algorithms for efficiently computing the CAP estimates for different levels of penalization and methods for choosing an appropriate level of penalization are proposed. The predictive and parsimony gains of employing CAP penalties are shown by means of a series of simulated examples. Next, we introduce the Sparse Pseudo-Likelihood Inverse Covariance Estimator (SPLICE): a &ell;1-penalized pseudo-likelihood estimate of precision matrices. SPLICE estimates can be efficiently computed at the higher range of values of the regularization parameter where our heuristic analysis suggests that the pseudo-likelihood approximation works best. Simulation studies suggest that, with scarce data, many selection criteria chose higher regularization levels where the performance of the exact and pseudo-likelihood estimates is comparable. Finally, we extend previous results in the literature so they can be used to characterize asymptotic distribution of many alternative combination of loss and penalty functions for parametric (low-dimensional) models. The approximations used to derive such asymptotic results also leads to a simple criterion determining sufficient conditions for the existence of a regularization level at which the signs of the penalized parameter estimate agree with the signs of the \"true parameter\".",
        "keywords": [
            "fitted parameter",
            "structured selection",
            "parameter selection",
            "regularization parameter",
            "hierarchical selection",
            "model selection",
            "parameter space",
            "penalty function",
            "CAP penalty",
            "penalized parameter estimate",
            "convex penalty",
            "true parameter",
            "CAP estimate",
            "covariance selection"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Guilherme N. L. Veiga Da Rocha",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "Sparsity and model selection through convex penalties: structured selection, covariance selection and some theory",
        "year": 2008
    },
    "ne8hy21S": {
        "id": "ne8hy21S",
        "title": "Predicting Execution Time of Computer Programs Using Sparse Polynomial Regression.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ling Huang",
                "org": ""
            },
            {
                "name": "Jinzhu Jia",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Byung-Gon Chun",
                "org": ""
            },
            {
                "name": "Petros Maniatis",
                "org": ""
            },
            {
                "name": "Mayur Naik",
                "org": ""
            }
        ],
        "venue": "NIPS",
        "year": 2010
    },
    "brLyDXg5": {
        "id": "brLyDXg5",
        "title": "Boosting With the<i>L</i><sub>2</sub>Loss",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Peter Bühlmann",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of The American Statistical Association",
        "year": 2003
    },
    "YHEPpsxM": {
        "id": "YHEPpsxM",
        "title": "Polar cloud detection using satellite data with analysis and application of kernel learning algorithms",
        "abstract": "Clouds play a major role in controlling Earth's climate, and studying global cloud distribution is the first step to advance our understanding and improve our prediction of global climate changes (such as global warming). However, cloud detection is particularly challenging in polar regions because of the snow and ice coverage. Collaborating with Dr. Eugene Clothiaux and Dr. Amy Braverman, we propose new algorithms to detection polar clouds using data collected by the Multi-angle Imaging SpectroRadiometer (MISR) and Moderate Resolution Imaging Spectroradiometer (MODIS). We devise an Enhanced Linear Correlation Matching Classification (ELCMC) algorithm to improve the MISR polar cloud detection based on the multi-angle information and the ELCMC algorithm provides a 92% average accuracy rate. The accuracy is further improved when the ELCMC results are used as labels to train nonlinear classifiers such as Quadratic Discriminate Analysis (QDA) or Gaussian kernel Support Vector Machines (SVM). Combining MISR data with the hyper-spectral information provided by MODIS, we propose an algorithm to improve the polar cloud detection. The highly accurate (97%) consensus pixels are used to train QDA on all MISR and MODIS features. Then the resulting classifier provides a 94% accuracy rate, higher than both the MISR rate (88%) and the MODIS rate (90%) over \"partly cloudy\" scenes. Because SVMs provide better classification results but require much more computation than QDA in the cloud detection problem, we use binning to reduce the computation of Gaussian kernel regularization methods. In regression we show that binning keeps the same minimax rates of the unbinned estimator and reduces the computation from O(n 3) to O(m3), with n as the sample size and m as the number of bins. To achieve the minimax rate in the k-th order Sobolev space, m needs to be in the order of O(kn 1/(2k+1)), which makes the computation of order O(n) for k = 1 and even less for larger k. On a particular polar scene, the SVM trained on 966 bins has a comparable test classification rate as the SVM trained on 27,179 samples, but significantly reduces the training time from 5.99 hours to 2.56 minutes.",
        "keywords": [
            "average accuracy rate",
            "comparable test classification rate",
            "accuracy rate",
            "satellite data",
            "cloud detection problem",
            "misr polar cloud detection",
            "combining misr data",
            "misr rate",
            "cloud detection",
            "minimax rate",
            "modis rate"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "Polar cloud detection using satellite data with analysis and application of kernel learning algorithms",
        "year": 2005
    },
    "F5fcor3v": {
        "id": "F5fcor3v",
        "title": "Disentangled Attribution Curves for Interpreting Random Forests and Boosted Trees.",
        "abstract": "  Tree ensembles, such as random forests and AdaBoost, are ubiquitous machine learning models known for achieving strong predictive performance across a wide variety of domains. However, this strong performance comes at the cost of interpretability (i.e. users are unable to understand the relationships a trained random forest has learned and why it is making its predictions). In particular, it is challenging to understand how the contribution of a particular feature, or group of features, varies as their value changes. To address this, we introduce Disentangled Attribution Curves (DAC), a method to provide interpretations of tree ensemble methods in the form of (multivariate) feature importance curves. For a given variable, or group of variables, DAC plots the importance of a variable(s) as their value changes. We validate DAC on real data by showing that the curves can be used to increase the accuracy of logistic regression while maintaining interpretability, by including DAC as an additional feature. In simulation studies, DAC is shown to out-perform competing methods in the recovery of conditional expectations. Finally, through a case-study on the bike-sharing dataset, we demonstrate the use of DAC to uncover novel insights into a dataset. ",
        "keywords": "",
        "authors": [
            {
                "name": "Summer Devlin",
                "org": ""
            },
            {
                "name": "Chandan Singh",
                "org": ""
            },
            {
                "name": "W. James Murdoch",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Machine Learning",
        "year": 2019
    },
    "3VZuH0mX": {
        "id": "3VZuH0mX",
        "title": "Three principles of data science - predictability, computability, and stability (PCS).",
        "abstract": "In this talk, Iu0027d like to discuss the intertwining importance and connections of three principles of data science in the title and the PCS workflow that is built on the three principles. The principles will be demonstrated in the context of two collaborative projects in neuroscience and genomics for interpretable data results and testable hypothesis generation.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley, USA"
            }
        ],
        "venue": "BigData",
        "year": 2018
    },
    "BUj4RUTk": {
        "id": "BUj4RUTk",
        "title": "Minimax-optimal rates for sparse additive models over kernel classes via convex programming",
        "abstract": "Sparse additive models are families of d-variate functions with the additive decomposition f* = Σj∈S fj*, where S is an unknown subset of cardinality s . In this paper, we consider the case where each univariate component function fj* lies in a reproducing kernel Hilbert space (RKHS), and analyze a method for estimating the unknown function f* based on kernels combined with l1-type convex regularization. Working within a high-dimensional framework that allows both the dimension d and sparsity s to increase with n, we derive convergence rates in the L2(P) and L2(Pn) norms over the class Fd,s,H of sparse additive models with each univariate function fj* in the unit ball of a univariate RKHS with bounded kernel function. We complement our upper bounds by deriving minimax lower bounds on the L2(P) error, thereby showing the optimality of our method. Thus, we obtain optimal minimax rates for many interesting classes of sparse additive models, including polynomials, splines, and Sobolev classes. We also show that if, in contrast to our univariate conditions, the d-variate function class is assumed to be globally bounded, then much faster estimation rates are possible for any sparsity s = Ω(√n), showing that global boundedness is a significant restriction in the high-dimensional setting.",
        "keywords": [
            "bounded kernel function",
            "convex programming",
            "univariate function fj",
            "additive decomposition",
            "univariate condition",
            "univariate component function fj",
            "kernel class",
            "unknown function",
            "d-variate function",
            "minimax-optimal rate",
            "sparse additive model",
            "d-variate function class",
            "univariate rkhs",
            "reproducing kernel hilbert space",
            "hilbert space",
            "convergence rate",
            "kernel",
            "lower bound",
            "additive model",
            "non parametric",
            "minimax",
            "sparse matrix",
            "convergence",
            "convex",
            "sparsity",
            "kernel functions",
            "mathematical programming",
            "information theory",
            "polynomials",
            "optimization"
        ],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": "Department of Statistics, University of California, Berkeley, CA"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Department of Statistics, University of California, Berkeley, CA and Department of Elecrical Engineering & Computer Science"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA and Department of Elecrical Engineering & Computer Science"
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2012
    },
    "Oo9s3kVK": {
        "id": "Oo9s3kVK",
        "title": "The DeepTune framework for modeling and characterizing neurons in visual cortex area V4",
        "abstract": "Deep neural network models have recently been shown to be effective in predicting single neuron responses in primate visual cortex areas V4. Despite their high predictive accuracy, these models are generally difficult to interpret. This limits their applicability in characterizing V4 neuron function. Here, we propose the DeepTune framework as a way to elicit interpretations of deep neural network-based models of single neurons in area V4. V4 is a midtier visual cortical area in the ventral visual pathway. Its functional role is not yet well understood. Using a dataset of recordings of 71 V4 neurons stimulated with thousands of static natural images, we build an ensemble of 18 neural network-based models per neuron that accurately predict its response given a stimulus image. To interpret and visualize these models, we use a stability criterion to form optimal stimuli (DeepTune images) by pooling the 18 models together. These DeepTune images not only confirm previous findings on the presence of diverse shape and texture tuning in area V4, but also provide rich, concrete and naturalistic characterization of receptive fields of individual V4 neurons. The population analysis of  DeepTune images for 71 neurons reveals how different types of curvature tuning are distributed in V4. In addition, it also suggests strong suppressive tuning for nearly half of the V4 neurons. Though we focus exclusively on the area V4, the DeepTune framework could be applied more generally to enhance the understanding of other visual cortex areas.",
        "keywords": "",
        "authors": [
            {
                "name": "Reza Abbasi-Asl",
                "org": "University of California, Berkeley;"
            },
            {
                "name": "Yuansi Chen",
                "org": "University of California, Berkeley;"
            },
            {
                "name": "Adam Bloniarz",
                "org": "University of California, Berkeley;"
            },
            {
                "name": "Michael Oliver",
                "org": "University of California, Berkeley;"
            },
            {
                "name": "Ben D.B. Willmore",
                "org": "University of Oxford"
            },
            {
                "name": "Jack L. Gallant",
                "org": "University of California, Berkeley;"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley;"
            }
        ],
        "venue": "bioRxiv",
        "year": 2018
    },
    "i7WQrvOc": {
        "id": "i7WQrvOc",
        "title": "Asymptotics and Coding Theory: One of the n → ∞ Dimensions of Terry",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": "university of california"
            }
        ],
        "venue": "",
        "year": 2012
    },
    "hUIIjcDV": {
        "id": "hUIIjcDV",
        "title": "904 On the Convergence of Boosting Procedures",
        "abstract": "",
        "keywords": [
            "loss function",
            "functional form"
        ],
        "authors": [
            {
                "name": "tong zhang",
                "org": "ibm"
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "international conference on machine learning",
        "year": 2013
    },
    "LnR3STcQ": {
        "id": "LnR3STcQ",
        "title": "The Limits of Random Fingerprinting",
        "abstract": "Various random fingerprinting methods are sometimes used to detect overlap between pairs of clones as a first step toward producing a minimal tiling path of clones for subsequent mapping and sequencing efforts. This paper evaluates and compares various statistical procedures for detecting pairwise overlap between clones when the fingerprints arise from any random process meeting simple, plausible assumptions about the relationship between overlap and the resulting fingerprint. Examples of such random processes include, but are not limited to, large-scale hybridization procedures designed to prepare tiling paths of clones for subsequent large-scale genomic sequencing. Our goals are to assess how well random fingerprinting can possibly detect overlap, to assess the effects of inevitable fingerprinting errors on statistical detection, to determine how one can make the best use of the data random fingerprinting provides, and to evaluate how well simple, heuristic techniques for overlap detection compare to more complex, likelihood-based approaches. The paper provides a quantitative assessment of the ability of any random fingerprinting procedure to detect various proportions of clonal overlap and shows the extent to which a small amount of experimental error will vitiate the performance of such techniques. The paper outlines a simple approximation method for constructing Bayesian overlap detectors, while concluding that detectors constructed from linear combinations of fingerprint data can be designed that will perform nearly as well as more complex, likelihood-based approaches.",
        "keywords": [
            "genome sequence",
            "random process"
        ],
        "authors": [
            {
                "name": "David O. Nelson",
                "org": "Human Genome Center, Lawrence Livermore National Laboratory, Livermore, California 94551, USA."
            },
            {
                "name": "Terence P. Speed",
                "org": "Statistics Department, University of California, Berkeley, California, 94720"
            },
            {
                "name": "Bin Yu",
                "org": "Statistics Department, University of California, Berkeley, California, 94720"
            }
        ],
        "venue": "Genomics",
        "year": 1997
    },
    "PpZBXIsA": {
        "id": "PpZBXIsA",
        "title": "The Geometry of Kernelized Spectral Clustering",
        "abstract": "Clustering of data sets is a standard problem in many areas of science and engineering. The method of spectral clustering is based on embedding the data set using a kernel function, and using the top eigenvectors of the normalized Laplacian to recover the connected components. We study the performance of spectral clustering in recovering the latent labels of i.i.d. samples from a finite mixture of nonparametric distributions. The difficulty of this label recovery problem depends on the overlap between mixture components and how easily a mixture component is divided into two nonoverlapping components. When the overlap is small compared to the indivisibility of the mixture components, the principal eigenspace of the population-level normalized Laplacian operator is approximately spanned by the square-root kernelized component densities. In the finite sample setting, and under the same assumption, embedded samples from different components are approximately orthogonal with high probability when the sample size is large. As a corollary we control the fraction of samples mislabeled by spectral clustering under finite mixtures with nonparametric components.",
        "keywords": [
            "Mixture model",
            "spectral clustering",
            "normalized Laplacian",
            "kernel function"
        ],
        "authors": [
            {
                "name": "geoffrey schiebinger",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "martin j wainwright",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "bin yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2014
    },
    "VUMJZRZa": {
        "id": "VUMJZRZa",
        "title": "Regeneration in Markov Chain Samplers",
        "abstract": " Markov chain sampling has received considerable attention in the recent literature, in particular inthe context of Bayesian computation and maximum likelihood estimation. This paper discusses theuse of Markov chain splitting, originally developed as a tool for the theoretical analysis of generalstate space Markov chains, to introduce regeneration times into Markov chain samplers. This allowsthe use of regenerative methods for analyzing the output of these samplers, and can also providea... ",
        "keywords": [
            "maximum likelihood estimate",
            "gibbs sampling",
            "markov chain monte carlo",
            "markov chain",
            "state space",
            "metropolis algorithm"
        ],
        "authors": [
            {
                "name": "Per Mykland",
                "org": ""
            },
            {
                "name": "Luke Tierney",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of the American Statistical Association",
        "year": 1994
    },
    "vkrNqELN": {
        "id": "vkrNqELN",
        "title": "Minimax Rates of Estimation for High-Dimensional Linear Regression Over $\\ell_q$ -Balls",
        "abstract": "Consider the high-dimensional linear regression model $y = X \\beta^* + w$, where $y \\in {\\BBR}^n$ is an observation vector, $X \\in {\\BBR}^{n \\times d}$ is a design matrix with $d n$, ${\\beta^*} \\in {\\BBR}^d$ is an unknown regression vector, and $w \\sim {\\cal N}(0, \\sigma^2 I)$ is additive Gaussian noise. This paper studies the minimax rates of convergence for estimating ${\\beta^*}$ in either $\\ell_2$-loss and $\\ell_2$-prediction loss, assuming that $\\beta^*$ belongs to an $\\ell_q$ -ball ${\\BBB}_q(R_q)$ for some $q \\in [0,1]$. It is shown that under suitable regularity conditions on the design matrix $X$, the minimax optimal rate in $\\ell_2$ -loss and $\\ell_2$-prediction loss scales as $\\Theta\\left(R_q \\left({\\log d \\over n}\\right)^{1-{q \\over 2}}\\right)$. The analysis in this paper reveals that conditions on the design matrix $X$ enter into the rates for $\\ell_2$-error and $\\ell_2$ -prediction error in complementary ways in the upper and lower bounds. Our proofs of the lower bounds are information theoretic in nature, based on Fano's inequality and results on the metric entropy of the balls ${\\BBB}_q(R_q)$, whereas our proofs of the upper bounds are constructive, involving direct analysis of least squares over $\\ell_q$ -balls. For the special case $q=0$, corresponding to models with an exact sparsity constraint, our results show that although computationally efficient $\\ell_1$-based methods can achieve the minimax rates up to constant factors, they require slightly stronger assumptions on the design matrix $X$ than optimal algorithms involving least-squares over the $\\ell_0$-ball.",
        "keywords": [
            "high-dimensional linear regression",
            "direct analysis",
            "prediction loss",
            "minimax optimal rate",
            "design matrix",
            "observation vector",
            "minimax rate",
            "prediction loss scale",
            "lower bound",
            "prediction error",
            "minimax rates",
            "high-dimensional linear regression model",
            "gaussian noise",
            "noise",
            "linear regression model",
            "null space",
            "least square",
            "linear regression",
            "compressed sensing",
            "regression analysis",
            "information theory",
            "entropy",
            "signal reconstruction",
            "rate of convergence",
            "upper and lower bounds",
            "measurement",
            "vectors",
            "upper bound"
        ],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": "Department of Statistics, University of California at Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Department of Statistics and Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics and Department of Electrical Engineering and Computer Science, University of California at Berkeley, Berkeley, CA, USA"
            }
        ],
        "venue": "IEEE Transactions on Information Theory",
        "year": 2011
    },
    "WxS2YUNS": {
        "id": "WxS2YUNS",
        "title": "Refining interaction search through signed iterative Random Forests.",
        "abstract": "Advances in supervised learning have enabled accurate prediction in biological systems governed by complex interactions among biomolecules. However, state-of-the-art predictive algorithms are typically black-boxes, learning statistical interactions that are difficult to translate into testable hypotheses. The iterative Random Forest (iRF) algorithm took a step towards bridging this gap by providing a computationally tractable procedure to identify the stable, high-order feature interactions that drive the predictive accuracy of Random Forests (RF). Here we refine the interactions identified by iRF to explicitly map responses as a function of interacting features. Our method, signed iRF (s-iRF), describes  of rules that frequently occur on RF decision paths. We refer to these rule subsets as signed interactions. Signed interactions share not only the same set of interacting features but also exhibit similar thresholding behavior, and thus describe a consistent functional relationship between interacting features and responses. We describe stable and predictive importance metrics (SPIMs) to rank signed interactions in terms of their stability, predictive accuracy, and strength of interaction. For each SPIM, we define null importance metrics that characterize its expected behavior under known structure. We evaluate our proposed approach in biologically inspired simulations and two case studies: predicting enhancer activity and spatial gene expression patterns. In the case of enhancer activity, s-iRF recovers one of the few experimentally validated high-order interactions and suggests novel enhancer elements where this interaction may be active. In the case of spatial gene expression patterns, s-iRF recovers all 11 reported links in the gap gene network. By refining the process of interaction recovery, our approach has the potential to guide mechanistic inquiry into systems whose scale and complexity is beyond human comprehension.",
        "keywords": "",
        "authors": [
            {
                "name": "Karl Kumbier",
                "org": "UC Berkeley;"
            },
            {
                "name": "Sumanta Basu",
                "org": "Cornell University;"
            },
            {
                "name": "James B. Brown",
                "org": "<institution>Centre for Computational Biology, School of Biosciences, University of Birmingham</institution>"
            },
            {
                "name": "Susan Celniker",
                "org": "Lawrence Berkeley National Laboratory"
            },
            {
                "name": "Bin Yu",
                "org": "UC Berkeley;"
            }
        ],
        "venue": "arXiv: Machine Learning",
        "year": 2018
    },
    "9CdqN8Ce": {
        "id": "9CdqN8Ce",
        "title": "Complexity Analysis of the Lasso Regularization Path",
        "abstract": "  The regularization path of the Lasso can be shown to be piecewise linear, making it possible to \"follow\" and explicitly compute the entire path. We analyze in this paper this popular strategy, and prove that its worst case complexity is exponential in the number of variables. We then oppose this pessimistic result to an (optimistic) approximate analysis: We show that an approximate path with at most O(1/sqrt(epsilon)) linear segments can always be obtained, where every point on the path is guaranteed to be optimal up to a relative epsilon-duality gap. We complete our theoretical analysis with a practical algorithm to compute these approximate paths. ",
        "keywords": [],
        "authors": [
            {
                "name": "Julien Mairal",
                "org": "university of california berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "university of california berkeley"
            }
        ],
        "venue": "ICML",
        "year": 2012
    },
    "KKN0utgT": {
        "id": "KKN0utgT",
        "title": "Lower bounds on expected redundancy for nonparametric classes",
        "abstract": "The article focuses on lower bound results on expected redundancy for universal coding of independent and identically distributed data on [0, 1] from parametric and nonparametric families. After reviewing existing lower bounds, we provide a new proof for minimax lower bounds on expected redundancy over nonparametric density classes. This new proof is based on the calculation of a mutual information quantity, or it utilizes the relationship between redundancy and Shannon capacity. It therefore unifies the minimax redundancy lower bound proofs in the parametric and nonparametric cases",
        "keywords": [
            "nonparametric class",
            "bound proof",
            "minimax lower bound",
            "minimax redundancy",
            "independent identically distributed data",
            "nonparametric density class",
            "parametric families",
            "encoding",
            "minimax lower bounds",
            "expected redundancy",
            "lower bound result",
            "nonparametric case",
            "new proof",
            "minimax techniques",
            "nonparametric density classes",
            "nonparametric families",
            "universal coding",
            "redundancy",
            "channel capacity",
            "lower bound",
            "mutual information",
            "shannon capacity",
            "nonparametric family",
            "independent and identically distributed",
            "parametric statistics",
            "stochastic processes"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Dept. of Stat., California Univ., Berkeley, CA"
            }
        ],
        "venue": "IEEE Transactions on Information Theory",
        "year": 1996
    },
    "fi5Za5Be": {
        "id": "fi5Za5Be",
        "title": "A fast lightweight approach to origin-destination IP traffic estimation using partial measurements",
        "abstract": "In this paper, a novel approach is proposed for estimating traffic matrices. Our method, called PamTram for PArtial Measurement of TRAffic Matrices, couples lightweight origin-destination (OD) flow measurements along with a computationally lightweight algorithm for producing OD estimates. The first key aspect of our method is to actively select a small number of informative OD flows to measure in each estimation interval. To avoid the heavy computation of optimal selection, we use intuition from game theory to develop randomized selection rules, with the goals of reducing errors and adapting to traffic changes. We show that it is sufficient to measure only one flow per measurement period to drastically reduce errors-thus rendering our method lightweight in terms of measurement overhead. The second key aspect is an explanation and proof that an Iterative Proportional Fitting algorithm approximates traffic matrix estimates when the goal is a minimum mean-squared error; this makes our method lightweight in terms of computation overhead. A one-step error bound is provided for PamTram that bounds the average error for the worst scenario. We validate our method using data from Sprint's European Tier-1 IP backbone network and demonstrate its consistent improvement over previous methods.",
        "keywords": [
            "game theory",
            "flow measurement",
            "minimum mean square error",
            "minimax",
            "iterative proportional fitting"
        ],
        "authors": [
            {
                "name": "Gang Liang",
                "org": "Department of Statistics, University of California at Irvine, Irvine, CA"
            },
            {
                "name": "Nina Taft",
                "org": "Intel Rearch Berkeley, Berkeley, CA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California at Berkeley, Berkeley, CA"
            }
        ],
        "venue": "IEEE Transactions on Information Theory",
        "year": 2006
    },
    "ZzVnmiJQ": {
        "id": "ZzVnmiJQ",
        "title": "Early stopping for non-parametric regression: An optimal data-dependent stopping rule.",
        "abstract": "",
        "keywords": [
            "Hilbert spaces",
            "eigenvalues and eigenfunctions",
            "gradient methods",
            "least squares approximations",
            "matrix algebra",
            "regression analysis",
            "Sobolev spaces",
            "additive noise variables",
            "early stopping strategy",
            "empirical kernel matrix eigenvalues",
            "finite-rank kernel classes",
            "function estimation",
            "gradient descent",
            "iterative algorithm",
            "least-squares loss minimization",
            "nonparametric regression",
            "optimal data-dependent stopping rule",
            "reproducing kernel Hilbert spaces",
            "step-sizes"
        ],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Allerton",
        "year": 2011
    },
    "Sv57pcvW": {
        "id": "Sv57pcvW",
        "title": "Regularization: sparsity, structure and computation",
        "abstract": "Regularization is a powerful yet versatile technique utilized by many successful modern methods in both machine learning and statistics community. This thesis makes contribution to the study of regularization in three major aspects. First, we introduce a family of penalty functions named Composite Absolute Penalties (CAP) that are highly customizable and through which one can incorporate structural information within the data into regularization in order to improve prediction and interpretation. Efficient computation algorithms are also provided for both computing the regularization path and selecting the amount of regularization. Secondly, we introduce a Booted Lasso (BLasso) algorithm that provides a conceptual link between the popular statistical method Lasso (Tibshirani, 1996) and the machine learning method Boosting (Freund, 1995). It also serves as a simple plug-in algorithm for tracing the regularization path of general convex loss functions with general convex penalties. Finally, we study the model selection consistency of the Lasso and gives an Irrepresentible Condition which is almost necessary and sufficient for Lasso to consistently select the correct model for both small p case and large p case. The proposed methods and works are supported with theories, simulations and experiments on real datasets.",
        "keywords": [
            "popular statistical method",
            "large p case",
            "correct model",
            "Booted Lasso",
            "general convex penalty",
            "model selection consistency",
            "method Boosting",
            "efficient computation algorithm",
            "general convex loss function",
            "regularization path"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Peng Zhao",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "Regularization: sparsity, structure and computation",
        "year": 2006
    },
    "akGxK8bf": {
        "id": "akGxK8bf",
        "title": "Interpretable machine learning: definitions, methods, and applications.",
        "abstract": "Machine-learning models have demonstrated great success in learning complex patterns that enable them to make predictions about unobserved data. In addition to using models for prediction, the ability to interpret what a model has learned is receiving an increasing amount of attention. However, this increased focus has led to considerable confusion about the notion of interpretability. In particular, it is unclear how the wide array of proposed interpretation methods are related, and what common concepts can be used to evaluate them.  aim to address these concerns by defining interpretability in the context of machine learning and introducing the Predictive, Descriptive, Relevant (PDR) framework for discussing interpretations. The PDR framework provides three overarching desiderata for evaluation: predictive accuracy, descriptive accuracy and relevancy, with relevancy judged relative to a human audience. Moreover, to help manage the deluge of interpretation methods, we introduce a categorization of existing techniques into model-based and post-hoc categories, with sub-groups including sparsity, modularity and simulatability. To demonstrate how practitioners can use the PDR framework to evaluate and understand interpretations, we provide numerous real-world examples. These examples highlight the often under-appreciated role played by human audiences in discussions of interpretability. Finally, based on our framework, we discuss limitations of existing methods and directions for future work. We hope that this work will provide a common vocabulary that will make it easier for both practitioners and researchers to discuss and choose from the full range of interpretation methods.",
        "keywords": "",
        "authors": [
            {
                "name": "W. James Murdoch",
                "org": ""
            },
            {
                "name": "Chandan Singh",
                "org": ""
            },
            {
                "name": "Karl Kumbier",
                "org": ""
            },
            {
                "name": "Reza Abbasi-Asl",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Machine Learning",
        "year": 2019
    },
    "Y711AKNA": {
        "id": "Y711AKNA",
        "title": "Discussions of boosting papers, and rejoinders",
        "abstract": "",
        "keywords": [
            "boosting"
        ],
        "authors": [
            {
                "name": "Peter L. Bartlett",
                "org": ""
            },
            {
                "name": "Peter J. Bickel",
                "org": ""
            },
            {
                "name": "Peter Bühlmann",
                "org": ""
            },
            {
                "name": "Yoav Freund",
                "org": ""
            },
            {
                "name": "Jerome Friedman",
                "org": ""
            },
            {
                "name": "Trevor Hastie",
                "org": ""
            },
            {
                "name": "Wenxin Jiang",
                "org": ""
            },
            {
                "name": "Michael J. Jordan",
                "org": ""
            },
            {
                "name": "Vladimir Koltchinskii",
                "org": ""
            },
            {
                "name": "Gábor Lugosi",
                "org": ""
            },
            {
                "name": "Jon D. McAuliffe",
                "org": ""
            },
            {
                "name": "Ya'acov Ritov",
                "org": ""
            },
            {
                "name": "Saharan Rosset",
                "org": ""
            },
            {
                "name": "Robert E. Schapire",
                "org": ""
            },
            {
                "name": "Robert Tibshirani",
                "org": ""
            },
            {
                "name": "Nicolas Vayatis",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Tong Zhang",
                "org": ""
            },
            {
                "name": "Ji Zhu",
                "org": ""
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2004
    },
    "eQXY7WpA": {
        "id": "eQXY7WpA",
        "title": "Sparse models for sparse data: methods, limitations, visualizations and ensembles",
        "abstract": "Significant recent advances in many areas of data collection and processing have introduced many challenges for modeling such data. Data sets have exploded in the number of observations and dimensionality. The explosion in dimensionality has led to advances in the modeling of high dimensional data with regularized and sparse models. One of the more interesting and challenging varieties of high dimensional data are sparse data sets. Sparse data sets arise from many important areas involving human-computer interaction, such as text and language processing, and human-human interaction, such as social networks. Our motivation in this thesis is to explore the use of sparse models for applications involving sparse data. In some cases, we have made improvements over previous methods that fundamentally involved dense models fitted on, and applied to, sparse data. In other cases, we have adapted sparse models developed for dense data sets. Along the way, we have encountered a recurring issue: due to both subsampling and regularization, we are faced with a problem that sparse models may not adequately capture the full dimensionality of such data and may be inadequate for prediction on test data. The utility of sparse models have been demonstrated in contexts with very high dimensional dense data. In this dissertation, we shall examine two applications and modeling methods involving sparse linear models and sparse matrix decompositions. Our first application involves natural language processing and ranking, the second involves recommendation systems and matrix factorization. In Chapter 2, we developed a novel and powerful visualization system. We named our system Bonsai as it enables a curated process of developing trees that partition the joint space of data and models. By exploring the product space of the space of training data, the space of modeling parameters, and the space of test data, we can explore how our models are developed based on the constraints imposed and the data they attempt to model or predict. More generally, we believe we have introduced a very fruitful means of exploring a multiplicity of models and a multiplicity of data samples. Chapter 3 is based on our work in the Netflix Prize competition. In contrast to others' use of dense models for this sparse data, we sought to introduce modeling methods with tunable sparsity. In this work, we found striking difficulties in modeling the data with sparse models, and identified concerns about the utility of sparse models for sparse data. In conclusion, this thesis presents several methods, and limitations of such methods, for modeling sparse data with sparse models. These limitations are suggestive of new directions to pursue. In particular, we are optimistic that future research in modeling methods may find new ways to tune models for density, when applied to sparse data, just as much research on models for dense data has involved tuning models for sparsity.",
        "keywords": [
            "data collection",
            "sparse model",
            "sparse data set",
            "sparse data",
            "data sample",
            "dense data",
            "data set",
            "test data",
            "high dimensional data",
            "dense data set"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            },
            {
                "name": "David Gregory Purdy",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "Sparse models for sparse data: methods, limitations, visualizations and ensembles",
        "year": 2012
    },
    "AKUU7U10": {
        "id": "AKUU7U10",
        "title": "Discovering word associations in news media via feature selection and sparse classification",
        "abstract": "We analyze the \"image\" of a given query word in a given corpus of text news by producing a short list of other words with which this query is strongly associated. We use a number of feature selection schemes for text classification to help in this task. We apply these classification techniques using indicators of the query word's appearance in each document used as the document \"labels\" and the indicators for all other words as document predictors/features. The features selected by any scheme is then considered the list of words comprising the query word's \"image\".\n\nTo be easily understandable, a list should be extremely short with respect to the dictionary of terms present in the corpus. The approach thus requires aggressive feature (word) selection in order to single out at most a few tens of terms in a universe of hundreds of thousands or more. In addition, a word imaging scheme should scale well with the size of data (number and size of documents, size of dictionary).\n\nWe produce one scheme for feature selection through a sparse classification model. A standard classification algorithm assigns one weight per term in the predictor dictionary, in order to maximize the capacity to successfully predict the labels of document units. By imposing a sparsity constraint on the weight vector, we single out the few words that are most able to predict the presence or absence of a query word in any document. This paper compares this and several other schemes that are potentially well suited to the task of word imaging, each method presenting a different manner of feature selection.\n\nWe present two evaluations of these schemes. One evaluates the predictive classification performance of a logistic regression model trained over the corpus using only a scheme's selected features. The other is based on the judgement of human readers: a pair of word lists generated by different schemes operating on identical queries are presented to a human subject alongside a trio of document units (paragraphs) containing the query word. This subject then chooses the list which in his/her estimation is the best summary of the document units.\n\nWe apply these schemes to study the images of frequently covered countries and regions in recent news articles from the International section of the New York Times. Our preliminary experiments indicate that, while most methods perform similarly well on our data in terms of predictive performance, human-based evaluations appear to favor features selected by training of sparse logistic regression, a penalized variant of logistic regression that encourages sparse classifiers. This indicates that classification metrics based on pure predictive performance, while useful as a indicator for pre-selecting algorithms, are not enough to predict human assessment of word association algorithms.\n\n",
        "keywords": [
            "feature selection",
            "sparse classification",
            "news media",
            "discovering word association",
            "logistic regression",
            "new media",
            "evaluation",
            "sparsity",
            "regularization",
            "logistic regression model"
        ],
        "authors": [
            {
                "name": "Brian Gawalt",
                "org": "University of California, Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Jinzhu Jia",
                "org": "University of California, Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Luke Miratrix",
                "org": "University of California, Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Laurent El Ghaoui",
                "org": "University of California, Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley, Berkeley, CA, USA"
            },
            {
                "name": "Sophie Clavier",
                "org": "San Francisco State University, San Francisco, CA, USA"
            }
        ],
        "venue": "Multimedia Information Retrieval",
        "year": 2010
    },
    "lggpG8hK": {
        "id": "lggpG8hK",
        "title": "Spectral clustering and the high-dimensional stochastic blockmodel",
        "abstract": "Networks or graphs can easily represent a diverse set of data sources that are characterized by interacting units or actors. Social networks, representing people who communicate with each other, are one example. Communities or clusters of highly connected actors form an essential feature in the structure of several empirical networks. Spectral clustering is a popular and computationally feasible method to discover these communities. The stochastic blockmodel [Social Networks 5 (1983) 109-137] is a social network model with well-defined communities; each node is a member of one community. For a network generated from the Stochastic Blockmodel, we bound the number of nodes \"misclustered\" by spectral clustering. The asymptotic results in this paper are the first clustering results that allow the number of clusters in the model to grow with the number of nodes, hence the name high-dimensional. In order to study spectral clustering under the stochastic blockmodel, we first show that under the more general latent space model, the eigenvectors of the normalized graph Laplacian asymptotically converge to the eigenvectors of a \"population\" normalized graph Laplacian. Aside from the implication for spectral clustering, this provides insight into a graph visualization technique. Our method of studying the eigenvectors of random matrices is original.",
        "keywords": [
            "Spectral clustering",
            "latent space model",
            "Stochastic Blockmodel",
            "clustering",
            "convergence of eigenvectors",
            "principal components analysis"
        ],
        "authors": [
            {
                "name": "karl rohe",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "sourav chatterjee",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "bin yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2010
    },
    "XaTlf1XD": {
        "id": "XaTlf1XD",
        "title": "Lower bounds on minimax rates for nonparametric regression with additive sparsity and smoothness.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "NIPS",
        "year": 2009
    },
    "8fLGy7Xg": {
        "id": "8fLGy7Xg",
        "title": "A path following algorithm for Sparse Pseudo-Likelihood Inverse\n  Covariance Estimation (SPLICE)",
        "abstract": "Given n observations of a p-dimensional random vector, the covariance matrix\nand its inverse (precision matrix) are needed in a wide range of applications.\nSample covariance (e.g. its eigenstructure) can misbehave when p is comparable\nto the sample size n. Regularization is often used to mitigate the problem.\n  In this paper, we proposed an l1-norm penalized pseudo-likelihood estimate\nfor the inverse covariance matrix. This estimate is sparse due to the l1-norm\npenalty, and we term this method SPLICE. Its regularization path can be\ncomputed via an algorithm based on the homotopy/LARS-Lasso algorithm.\nSimulation studies are carried out for various inverse covariance structures\nfor p=15 and n=20, 1000. We compare SPLICE with the l1-norm penalized\nlikelihood estimate and a l1-norm penalized Cholesky decomposition based\nmethod. SPLICE gives the best overall performance in terms of three metrics on\nthe precision matrix and ROC curve for model selection. Moreover, our\nsimulation results demonstrate that the SPLICE estimates are positive-definite\nfor most of the regularization path even though the restriction is not\nenforced.",
        "keywords": [
            "algorithms",
            "statistics",
            "cholesky decomposition",
            "roc curve",
            "statistical computing",
            "positive definite",
            "decomposition",
            "sample size",
            "inverse problems",
            "simulation",
            "covariance estimation",
            "covariance matrix",
            "covariance",
            "model selection"
        ],
        "authors": [
            {
                "name": "Guilherme V. Rocha",
                "org": ""
            },
            {
                "name": "Peng Zhao",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "7Z8MmaoF": {
        "id": "7Z8MmaoF",
        "title": "Minimax rates of convergence for high-dimensional regression under lq-ball sparsity",
        "abstract": "Consider the standard linear regression model y = Xβ* + w, where y ∈ Rn is an observation vector, X ∈ Rn×d is a measurement matrix, β* ∈ Rd is the unknown regression vector, and w ∼ N(0, σ2I) is additive Gaussian noise. This paper determines sharp minimax rates of convergence for estimation of β* in l2 norm, assuming that β* belongs to a weak lq-ball Bq(Rq) for some q ∈ [0, 1]. We show that under suitable regularity conditions on the design matrix X, the minimax error in squared l2-norm scales as Rq (log d/n)1-q/2. In addition, we provide lower bounds on rates of convergence for general lp norm (for all p ∈ [1, + ∞], p ≠ q). Our proofs of the lower bounds are information-theoretic in nature, based on Fano's inequality and results on the metric entropy of the balls Bq(Rq). Matching upper bounds are derived by direct analysis of the solution to an optimization algorithm over Bq(Rq). We prove that the conditions on X required by optimal algorithms are satisfied with high probability by broad classes of noni.i.d. Gaussian random matrices, for which RIP or other sparse eigenvalue conditions are violated. For q = 0, l1- based methods (Lasso and Dantzig selector) achieve the minimax optimal rates in l2 error, but require stronger regularity conditions on the design than the nonconvex optimization algorithm used to determine the minimax upper bounds.",
        "keywords": [
            "design matrix X",
            "minimax upper bound",
            "Gaussian random matrix",
            "lower bound",
            "minimax error",
            "balls Bq",
            "additive Gaussian noise",
            "minimax optimal rate",
            "sharp minimax rate",
            "lq-ball sparsity",
            "general lp norm",
            "Minimax rate",
            "high-dimensional regression"
        ],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": "Department of Statistics, UC Berkeley, Berkeley, CA"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Department of Statistics and Department of EECS, UC Berkeley, Berkeley, CA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics and Department of EECS, UC Berkeley, Berkeley, CA"
            }
        ],
        "venue": "Allerton'09 Proceedings of the 47th annual Allerton conference on Communication, control, and computing",
        "year": 2009
    },
    "Y3aXfQyj": {
        "id": "Y3aXfQyj",
        "title": "Log-concave sampling: Metropolis-Hastings algorithms are fast!",
        "abstract": "We consider the problem of sampling from a strongly log-concave density in (mathbb{R}^d), and prove a non- asymptotic upper bound on the mixing time of the Metropolis-adjusted Langevin algorithm (MALA). The method draws samples by running a Markov chain obtained from the discretization of an appropriate Langevin diffusion, combined with an accept-reject step to ensure the correct stationary distribution. Relative to known guarantees for the unadjusted Langevin algorithm (ULA), our bounds reveal that the use of an accept-reject step in MALA leads to an exponentially improved dependence on the error-tolerance. Concretely, in order to obtain samples with TV error at most δ for a density with condition number κ, we show that MALA requires (O(kappa d log(1/delta))) steps, as compared to the (O(kappa^2d/delta^2)) steps established in past work on ULA. We also demonstrate the gains of MALA over ULA for weakly log-concave densities. Furthermore, we derive mixing time bounds for a zeroth-order method Metropolized random walk (MRW) and show that it mixes (O(kappa d)) slower than MALA. We provide numerical examples that support our theoretical findings, and demonstrate the potential gains of Metropolis-Hastings adjustment for Langevin-type algorithms.",
        "keywords": "",
        "authors": [
            {
                "name": "Raaz Dwivedi",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Yuansi Chen",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "COLT",
        "year": 2018
    },
    "OFnViJff": {
        "id": "OFnViJff",
        "title": "Counting and exploring sizes of Markov equivalence classes of directed acyclic graphs.",
        "abstract": "When learning a directed acyclic graph (DAG) model via observational data, one generally cannot identify the underlying DAG, but can potentially obtain a Markov equivalence class. The size (the number of DAGs) of a Markov equivalence class is crucial to infer causal effects or to learn the exact causal DAG via further interventions. Given a set of Markov equivalence classes, the distribution of their sizes is a key consideration in developing learning methods. However, counting the size of an equivalence class with many vertices is usually computationally infeasible, and the existing literature reports the size distributions only for equivalence classes with ten or fewer vertices.In this paper, we develop a method to compute the size of a Markov equivalence class. We first show that there are five types of Markov equivalence classes whose sizes can be formulated as five functions of the number of vertices respectively. Then we introduce a new concept of a rooted sub-class. The graph representations of rooted subclasses of a Markov equivalence class are used to partition this class recursively until the sizes of all rooted subclasses can be computed via the five functions. The proposed size counting is efficient for Markov equivalence classes of sparse DAGs with hundreds of vertices. Finally, we explore the size and edge distributions of Markov equivalence classes and find experimentally that, in general, (1) most Markov equivalence classes are half completed and their average sizes are small, and (2) the sizes of sparse classes grow approximately exponentially with the numbers of vertices.",
        "keywords": "",
        "authors": [
            {
                "name": "Yangbo He",
                "org": ""
            },
            {
                "name": "Jinzhu Jia",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": "Departments of Statistics and EECS, University of California at Berkeley, Berkeley, CA#TAB#"
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2015
    },
    "CcNdEVhK": {
        "id": "CcNdEVhK",
        "title": "On Model Selection Consistency of Lasso",
        "abstract": "Sparsity or parsimony of statistical models is crucial for their proper interpretations, as in sciences and social sciences. Model selection is a commonly used method to find such models, but usually involves a computationally heavy combinatorial search. Lasso (Tibshirani, 1996) is now being used as a computationally feasible alternative to model selection. Therefore it is important to study Lasso for model selection purposes. In this paper, we prove that a single condition, which we call the Irrepresentable Condition, is almost necessary and sufficient for Lasso to select the true model both in the classical fixed p setting and in the large p setting as the sample size n gets large. Based on these results, sufficient conditions that are verifiable in practice are given to relate to previous works and help applications of Lasso for feature selection and sparse representation. This Irrepresentable Condition, which depends mainly on the covariance of the predictor variables, states that Lasso selects the true model consistently if and (almost) only if the predictors that are not in the true model are \"irrepresentable\" (in a sense to be clarified) by predictors that are in the true model. Furthermore, simulations are carried out to provide insights and understanding of this result.",
        "keywords": [
            "feature selection",
            "classical fixed p setting",
            "irrepresentable condition",
            "consistency",
            "model selection purpose",
            "regularization",
            "model selection",
            "large p",
            "true model",
            "computationally heavy combinatorial search",
            "model selection consistency",
            "statistical model",
            "lasso",
            "computationally feasible alternative",
            "sparsity",
            "social science",
            "sparse representation",
            "sample size"
        ],
        "authors": [
            {
                "name": "Peng Zhao",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2006
    },
    "1QiFa9oO": {
        "id": "1QiFa9oO",
        "title": "Lower bounds on expected redundancy",
        "abstract": "",
        "keywords": [
            "redundancy",
            "stochastic processes",
            "mutual information",
            "hypercubes",
            "data compression",
            "parametric statistics",
            "lower bound"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "university of california"
            }
        ],
        "venue": "workshop on information technologies and systems",
        "year": 1994
    },
    "M8eyX7kg": {
        "id": "M8eyX7kg",
        "title": "Polar Cloud Detection using MISR and MODIS Data",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Eugene E. Clothiaux",
                "org": ""
            },
            {
                "name": "Amy J. Braverman",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "s0T6jf5y": {
        "id": "s0T6jf5y",
        "title": "On model selection consistency of the elastic net when p ≫ n",
        "abstract": "We study the model selection property of the Elastic Net. In the classical settings when p (the number of predictors) and q (the number of predictors with non-zero coefficients in the true linear model) are fixed, Yuan and Lin (2007) give a necessary and sufficient condition for the Elastic Net to consistently select the true model. They showed that it consistently selects the true model if and only if there exist suitable sequences λ1 (n) and λ2 (n) that satisfy EIC (which is defined later in the paper). Here we study the general case when p, q, and n all go to infinity. For general scalings of p, q, and n, when gaussian noise is assumed, sufficient conditions are given such that EIC guarantees the Elastic Net's model selection consistency. We show that to make these conditions hold, n should grow at a rate faster than qlog(p - q). We compare the variable selection performance of the Elastic Net with that of the Lasso. Through theoretical results find simulation studies, we provide insights into when the Elastic Net can consistently select the true model even when the Lasso cannot. We also point out through examples that when the Lasso cannot select the true model, it is very likely that the Elastic Net cannot select the true model either.",
        "keywords": [
            "Elastic irrepresentable condition",
            "Elastic net",
            "Irrepresentable condition",
            "Lasso",
            "Model selection consistency"
        ],
        "authors": [
            {
                "name": "Jinzhu Jia",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "UC Berkeley(University of California),Berkeley,United States"
            }
        ],
        "venue": "Statistica Sinica",
        "year": 2010
    },
    "JivjWmb8": {
        "id": "JivjWmb8",
        "title": "High-dimensional covariance estimation by minimizing $\\ell_1$-penalized\n  log-determinant divergence",
        "abstract": "Given i.i.d. observations of a random vector $X \\in \\mathbb{R}^p$, we study\nthe problem of estimating both its covariance matrix $\\Sigma^*$, and its\ninverse covariance or concentration matrix {$\\Theta^* = (\\Sigma^*)^{-1}$.} We\nestimate $\\Theta^*$ by minimizing an $\\ell_1$-penalized log-determinant Bregman\ndivergence; in the multivariate Gaussian case, this approach corresponds to\n$\\ell_1$-penalized maximum likelihood, and the structure of $\\Theta^*$ is\nspecified by the graph of an associated Gaussian Markov random field. We\nanalyze the performance of this estimator under high-dimensional scaling, in\nwhich the number of nodes in the graph $p$, the number of edges $s$ and the\nmaximum node degree $d$, are allowed to grow as a function of the sample size\n$n$. In addition to the parameters $(p,s,d)$, our analysis identifies other key\nquantities covariance matrix $\\Sigma^*$; and (b) the $\\ell_\\infty$ operator\nnorm of the sub-matrix $\\Gamma^*_{S S}$, where $S$ indexes the graph edges, and\n$\\Gamma^* = (\\Theta^*)^{-1} \\otimes (\\Theta^*)^{-1}$; and (c) a mutual\nincoherence or irrepresentability measure on the matrix $\\Gamma^*$ and (d) the\nrate of decay $1/f(n,\\delta)$ on the probabilities $ \\{|\\hat{\\Sigma}^n_{ij}-\n\\Sigma^*_{ij}| > \\delta \\}$, where $\\hat{\\Sigma}^n$ is the sample covariance\nbased on $n$ samples. Our first result establishes consistency of our estimate\n$\\hat{\\Theta}$ in the elementwise maximum-norm. This in turn allows us to\nderive convergence rates in Frobenius and spectral norms, with improvements\nupon existing results for graphs with maximum node degrees $d = o(\\sqrt{s})$.\nIn our second result, we show that with probability converging to one, the\nestimate $\\hat{\\Theta}$ correctly specifies the zero pattern of the\nconcentration matrix $\\Theta^*$.",
        "keywords": [
            "concentration",
            "precision",
            "ℓ1 regularization",
            "gaussia n graphical models",
            "and phrases:covariance",
            "sparsity",
            "indexation",
            "covariance estimation",
            "operator norm",
            "sample size",
            "convergence rate",
            "spectral norm",
            "covariance matrix",
            "covariance"
        ],
        "authors": [
            {
                "name": "Pradeep Ravikumar",
                "org": "University of California , Berkeley"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "University of California , Berkeley"
            },
            {
                "name": "Garvesh Raskutti",
                "org": "University of California , Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "University of California , Berkeley"
            }
        ],
        "venue": "Electronic Journal of Statistics",
        "year": 2008
    },
    "ThTLMJGT": {
        "id": "ThTLMJGT",
        "title": "Optimal M-estimation in high-dimensional regression.",
        "abstract": "We consider, in the modern setting of high-dimensional statistics, the classic problem of optimizing the objective function in regression using M-estimates when the error distribution is assumed to be known. We propose an algorithm to compute this optimal objective function that takes into account the dimensionality of the problem. Although optimality is achieved under assumptions on the design matrix that will not always be satisfied, our analysis reveals generally interesting families of dimension-dependent objective functions.",
        "keywords": [
            "prox function",
            "robust regression",
            "algorithms",
            "regression analysis",
            "computer simulation"
        ],
        "authors": [
            {
                "name": "Derek Bean",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720"
            },
            {
                "name": "Peter J Bickel",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720"
            },
            {
                "name": "Noureddine El Karoui",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2013
    },
    "RQ8D5Mb7": {
        "id": "RQ8D5Mb7",
        "title": "Do retinal ganglion cells project natural scenes to their principal subspace and whiten them?",
        "abstract": "Several theories of early sensory processing suggest that it whitens sensory stimuli. Here, we test three key predictions of the whitening theory using recordings from 152 ganglion cells in salamander retina responding to natural movies. We confirm the previous finding that firing rates of ganglion cells are less correlated compared to natural scenes, although significant correlations remain. We show that while the power spectrum of ganglion cells decays less steeply than that of natural scenes, it is not completely flattened. Finally, we find evidence that only the top principal components of the visual stimulus are transmitted.",
        "keywords": "",
        "authors": [
            {
                "name": "Reza Abbasi-Asl",
                "org": "Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA"
            },
            {
                "name": "Cengiz Pehlevan",
                "org": "Center for Computational Biology, Flatiron Institute, New York, NY"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA"
            },
            {
                "name": "Dmitri B. Chklovskii",
                "org": "Center for Computational Biology, Flatiron Institute, New York, NY"
            }
        ],
        "venue": "ACSSC",
        "year": 2016
    },
    "luSw4HdM": {
        "id": "luSw4HdM",
        "title": "Sparse Boosting",
        "abstract": "We propose Sparse Boosting (the SparseL2Boost algorithm), a variant on boosting with the squared error loss. SparseL2Boost yields sparser solutions than the previously proposed L2Boosting by minimizing some penalized L2-loss functions, the FPE model selection criteria, through small-step gradient descent. Although boosting may give already relatively sparse solutions, for example corresponding to the soft-thresholding estimator in orthogonal linear models, there is sometimes a desire for more sparseness to increase prediction accuracy and ability for better variable selection: such goals can be achieved with SparseL2Boost. We prove an equivalence of SparseL2Boost to Breiman's nonnegative garrote estimator for orthogonal linear models and demonstrate the generic nature of SparseL2Boost for nonparametric interaction modeling. For an automatic selection of the tuning parameter in SparseL2Boost we propose to employ the gMDL model selection criterion which can also be used for early stopping of L2Boosting. Consequently, we can select between SparseL2Boost and L2Boosting by comparing their gMDL scores.",
        "keywords": [
            "gMDL score",
            "soft-thresholding estimator",
            "automatic selection",
            "SparseL2Boost algorithm",
            "gMDL model selection criterion",
            "orthogonal linear model",
            "Sparse Boosting",
            "nonnegative garrote estimator",
            "better variable selection",
            "SparseL2Boost yield",
            "FPE model selection criterion"
        ],
        "authors": [
            {
                "name": "Peter Bühlmann",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2006
    },
    "SgXzEssB": {
        "id": "SgXzEssB",
        "title": "Interpreting Convolutional Neural Networks Through Compression.",
        "abstract": "Convolutional neural networks (CNNs) achieve state-of-the-art performance in a wide variety of tasks in computer vision. However, interpreting CNNs still remains a challenge. This is mainly due to the large number of parameters in these networks. Here, we investigate the role of compression and particularly pruning filters in the interpretation of CNNs. We exploit our recently-proposed greedy structural compression scheme that prunes filters in a trained CNN. In our compression, the filter importance index is defined as the classification accuracy reduction (CAR) of the network after pruning that filter. The filters are then iteratively pruned based on the CAR index. We demonstrate the interpretability of CAR-compressed CNNs by showing that our algorithm prunes filters with visually redundant pattern selectivity. Specifically, we show the importance of shape-selective filters for object recognition, as opposed to color-selective filters. Out of top 20 CAR-pruned filters in AlexNet, 17 of them in the first layer and 14 of them in the second layer are color-selective filters. Finally, we introduce a variant of our CAR importance index that quantifies the importance of each image class to each CNN filter. We show that the most and the least important class labels present a meaningful interpretation of each filter that is consistent with the visualized pattern selectivity of that filter.",
        "keywords": "",
        "authors": [
            {
                "name": "Reza Abbasi-Asl",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Machine Learning",
        "year": 2017
    },
    "UOrmeYWq": {
        "id": "UOrmeYWq",
        "title": "The Lasso under Heteroscedasticity",
        "abstract": "The performance of the Lasso is well understood under the assumptions of the\nstandard linear model with homoscedastic noise. However, in several\napplications, the standard model does not describe the important features of\nthe data. This paper examines how the Lasso performs on a non-standard model\nthat is motivated by medical imaging applications. In these applications, the\nvariance of the noise scales linearly with the expectation of the observation.\nLike all heteroscedastic models, the noise terms in this Poisson-like model are\n\\textit{not} independent of the design matrix.\n  More specifically, this paper studies the sign consistency of the Lasso under\na sparse Poisson-like model. In addition to studying sufficient conditions for\nthe sign consistency of the Lasso estimate, this paper also gives necessary\nconditions for sign consistency. Both sets of conditions are comparable to\nresults for the homoscedastic model, showing that when a measure of the signal\nto noise ratio is large, the Lasso performs well on both Poisson-like data and\nhomoscedastic data.\n  Simulations reveal that the Lasso performs equally well in terms of model\nselection performance on both Poisson-like data and homoscedastic data (with\nproperly scaled noise variance), across a range of parameterizations. Taken as\na whole, these results suggest that the Lasso is robust to the Poisson-like\nheteroscedastic noise.",
        "keywords": [
            "poisson-like model",
            "sign consistency",
            "poisson-like model than those from the standard model",
            "conflrming our theoretical flndings. keywords: lasso",
            "heteroscedasticity",
            "model selection",
            "signal to noise ratio",
            "linear model",
            "standard model"
        ],
        "authors": [
            {
                "name": "Jinzhu Jia",
                "org": ""
            },
            {
                "name": "Karl Rohe",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "lhgztWhp": {
        "id": "lhgztWhp",
        "title": "Structural Compression of Convolutional Neural Networks Based on Greedy Filter Pruning.",
        "abstract": "Convolutional neural networks (CNNs) have state-of-the-art performance on many problems in machine vision. However, networks with superior performance often have millions of weights so that it is difficult or impossible to use CNNs on computationally limited devices or to humanly interpret them. A myriad of CNN compression approaches have been proposed and they involve pruning and compressing the weights and filters. In this article, we introduce a greedy structural compression scheme that prunes filters in a trained CNN. We define a filter importance index equal to the classification accuracy reduction (CAR) of the network after pruning that filter (similarly defined as RAR for regression). We then iteratively prune filters based on the CAR index. This algorithm achieves substantially higher classification accuracy in AlexNet compared to other structural compression schemes that prune filters. Pruning half of the filters in the first or second layer of AlexNet, our CAR algorithm achieves 26% and 20% higher classification accuracies respectively, compared to the best benchmark filter pruning scheme. Our CAR algorithm, combined with further weight pruning and compressing, reduces the size of first or second convolutional layer in AlexNet by a factor of 42, while achieving close to original classification accuracy through retraining (or fine-tuning) network. Finally, we demonstrate the interpretability of CAR-compressed CNNs by showing that our algorithm prunes filters with visually redundant functionalities. In fact, out of top 20 CAR-pruned filters in AlexNet, 17 of them in the first layer and 14 of them in the second layer are color-selective filters as opposed to shape-selective filters. To our knowledge, this is the first reported result on the connection between compression and interpretability of CNNs.",
        "keywords": "",
        "authors": [
            {
                "name": "Reza Abbasi-Asl",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Computer Vision and Pattern Recognition",
        "year": 2017
    },
    "BHOh4I0l": {
        "id": "BHOh4I0l",
        "title": "Ten Simple Rules for Effective Statistical Practice.",
        "abstract": "Several months ago, Phil Bourne, the initiator and frequent author of the wildly successful and incredibly useful “Ten Simple Rules” series, suggested that some statisticians put together a Ten Simple Rules article related to statistics. (One of the rules for writing a PLOS Ten Simple Rules article is to be Phil Bourne [1]. In lieu of that, we hope effusive praise for Phil will suffice.)Implicit in the guidelines for writing Ten Simple Rules [1] is “know your audience.” We developed our list of rules with researchers in mind: researchers having some knowledge of statistics, possibly with one or more statisticians available in their building, or possibly with a healthy do-it-yourself attitude and a handful of statistical packages on their laptops. We drew on our experience in both collaborative research and teaching, and, it must be said, from our frustration at being asked, more than once, to “take a quick look at my student’s thesis/my grant application/my referee’s report: it needs some input on the stats, but it should be pretty straightforward.”There are some outstanding resources available that explain many of these concepts clearly and in much more detail than we have been able to do here: among our favorites are Cox and Donnelly [2], Leek [3], Peng [4], Kass et al. [5], Tukey [6], and Yu [7].Every article on statistics requires at least one caveat. Here is ours: we refer in this article to “science” as a convenient shorthand for investigations using data to study questions of interest. This includes social science, engineering, digital humanities, finance, and so on. Statisticians are not shy about reminding administrators that statistical science has an impact on nearly every part of almost all organizations.",
        "keywords": "",
        "authors": [
            {
                "name": "Robert E. Kass",
                "org": "Department of Statistics, Machine Learning Department, and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America"
            },
            {
                "name": "Brian S. Caffo",
                "org": "Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America"
            },
            {
                "name": "Marie Davidian",
                "org": "Department of Statistics, North Carolina State University, Raleigh, North Carolina, United States of America"
            },
            {
                "name": "Xiao-Li Meng",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics and Department of Electrical Engineering and Computer Science, University of California Berkeley, Berkeley, California, United States of America"
            },
            {
                "name": "Nancy Reid",
                "org": "Department of Statistical Sciences, University of Toronto, Toronto, Ontario, Canada"
            }
        ],
        "venue": "PLoS Computational Biology",
        "year": 2016
    },
    "ByBljiZz": {
        "id": "ByBljiZz",
        "title": "MISR Cloud Detection over Ice and Snow Based on Linear Correlation Matching",
        "abstract": "Cloud detection is a crucial step in any climate modelling or prediction. Multi-angle Imaging SpectroRadiometer (MISR) was launched in 1999 by NASA to provide 9 angle and 4 band data to retrieve or estimate the cloud height and hence cloud detection. However, cloud detection even with MISR data has been proven very di-cult over ice and snow. In this paper, we bypass the cloud height estimation step to directly tackle cloud detection by using features of ice and snow (no cloud) pixels from difierent MISR angles. We propose the linear correlation matching classiflcation (LCMC) algorithm based on Fisher linear correlation tests. We compare LCMC with the Steroscopically-Derived Cloud Mask (SDCM), which is the cloud mask from MISR Level 2 Top-of-the atmosphere Cloud algorithm (known as L2TC), and flnd that LCMC gives more coverage and more robust results judged by visual inspection of flner resolution images. LCMC can also detect the very thin clouds most of the time. Moreover, LCMC is computationally much faster than L2TC and easier to implement. We hope to combine LCMC with L2TC in the future to improve the accuracy of the L2TC cloud height retrieval.",
        "keywords": [
            "index terms",
            "multi-angle imaging spectroradiometer misr",
            "ice and snow",
            "linear correlation.",
            "cloud detection",
            "snow",
            "height",
            "classification",
            "correlation",
            "spectroradiometers"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics|University of California , Berkeley"
            },
            {
                "name": "Amy Braverman",
                "org": "Jet Propulsion Laboratory|California Institute of Technology"
            }
        ],
        "venue": "",
        "year": 2003
    },
    "Qr0fKiX6": {
        "id": "Qr0fKiX6",
        "title": "Adjusting treatment effect estimates by post-stratification in randomized experiments",
        "abstract": "",
        "keywords": [
            "blocking",
            "randomized trials"
        ],
        "authors": [
            {
                "name": "luke miratrix",
                "org": "harvard university"
            },
            {
                "name": "jasjeet s sekhon",
                "org": "university of california berkeley"
            },
            {
                "name": "bin yu",
                "org": "university of california berkeley"
            }
        ],
        "venue": "Journal of The Royal Statistical Society Series B-statistical Methodology",
        "year": 2013
    },
    "ZOD4VL7l": {
        "id": "ZOD4VL7l",
        "title": "Data compression and histograms",
        "abstract": "Summary In this paper, the relationship between code length and the selection of the number of bins for a histogram density is considered for a sequence of iid observations on [0,1]. First, we use a shortest code length criterion to select the number of bins for a histogram. A uniform almost sure asymptotic expansion for the code length is given and it is used to prove the asymptotic optimality of the selection rule. In addition, the selection rule is consistent if the true density is uniform [0,1]. Secondly, we deal with the problem: what is the “best” achievable average code length with underlying density functionf? Minimax lower bounds are derived for the average code length over certain smooth classes of underlying densitiesf. For the smooth class with bounded first derivatives, the rate in the lower bound is shown to be achieved by a code based on a sequence of histograms whose number of bins is changed predictively. Moreover, this best code can be modified to ensure that the almost sure version of the code length has asymptotically the same behavior as its expected value, i.e., the average code length.",
        "keywords": [
            "lower bound",
            "data compression",
            "asymptotic expansion",
            "expected value"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Statistics University of Wisconsin 53706 Madison WI USA"
            },
            {
                "name": "T. P. Speed",
                "org": "Department of Statisties University of California 94720 Berkeley CA USA"
            }
        ],
        "venue": "Probability Theory and Related Fields",
        "year": 1992
    },
    "NgkPsoSD": {
        "id": "NgkPsoSD",
        "title": "Challenges with EM in application to weakly identifiable mixture models.",
        "abstract": "We study a class of weakly identifiable location-scale mixture models for which the maximum likelihood estimates based on $n$ i.i.d. samples are known to have lower accuracy than the classical $n^{- frac{1}{2}}$ error. We investigate whether the Expectation-Maximization (EM) algorithm also converges slowly for these models. We first demonstrate via simulation studies a broad range of over-specified mixture models for which the EM algorithm converges very slowly, both in one and higher dimensions. We provide a complete analytical characterization of this behavior for fitting data generated from a multivariate standard normal distribution using two-component Gaussian mixture with varying location and scale parameters. Our results reveal distinct regimes in the convergence behavior of EM as a function of the dimension $d$. In the multivariate setting ($d geq 2$), when the covariance matrix is constrained to a multiple of the identity matrix, the EM algorithm converges in order $(n/d)^{frac{1}{2}}$ steps and returns estimates that are at a Euclidean distance of order ${(n/d)^{-frac{1}{4}}}$ and ${ (n d)^{- frac{1}{2}}}$ from the true location and scale parameter respectively. On the other hand, in the univariate setting ($d = 1$), the EM algorithm converges in order $n^{frac{3}{4} }$ steps and returns estimates that are at a Euclidean distance of order ${ n^{- frac{1}{8}}}$ and ${ n^{-frac{1} {4}}}$ from the true location and scale parameter respectively. Establishing the slow rates in the univariate setting requires a novel localization argument with two stages, with each stage involving an epoch-based argument applied to a different surrogate EM operator at the population level. We also show multivariate ($d geq 2$) examples, involving more general covariance matrices, that exhibit the same slow rates as the univariate case.",
        "keywords": "",
        "authors": [
            {
                "name": "Raaz Dwivedi",
                "org": ""
            },
            {
                "name": "Nhat Ho",
                "org": ""
            },
            {
                "name": "Koulik Khamaru",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Michael I. Jordan",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Statistics Theory",
        "year": 2019
    },
    "wK3ZvqvU": {
        "id": "wK3ZvqvU",
        "title": "Data Wisdom in Computational Genomics Research",
        "abstract": "All fields of science are now inundated with massive amounts of data, which have the potential to answer fundamental questions. Genomics is one particular example, exploring questions like: How does the human genome work? What genome variants make us more prone to diseases? To find answers to these questions, it is crucial to develop statistical and machine learning methods that can scale up, particularly through efficient data storage and communication. Equally crucial, but less emphasized, is the possession of data wisdom—a rebranding of the best elements of applied statistics in a recent note at ODBMS.org (http://www.odbms.org/2015/04/data-wisdom-for-data-science/). The note at ODBMS.org contains ten sets of questions a practitioner can ask to cultivate data wisdom. Although there has been much recent excitement about big data, having enough data relevant to the problem is the key to gaining meaningful answers in genomics. Data wisdom gives us the insight into how these data would look, how much information a dataset really contains, and how to extract it. In this paper, we expand on the ten sets of questions and illustrate where and how data wisdom can be integrated into computational genomics research.",
        "keywords": "",
        "authors": [
            {
                "name": "Haiyan Huang",
                "org": "University of California"
            },
            {
                "name": "Bin Yu",
                "org": "University of California"
            }
        ],
        "venue": "Statistics in Biosciences",
        "year": 2017
    },
    "akq1JLrQ": {
        "id": "akq1JLrQ",
        "title": "Reversible MCMC on Markov equivalence classes of sparse directed acyclic graphs",
        "abstract": "Graphical models are popular statistical tools which are used to represent dependent or causal complex systems. Statistically equivalent causal or directed graphical models are said to belong to a Markov equivalent class. It is of great interest to describe and understand the space of such classes. However, with currently known algorithms, sampling over such classes is only feasible for graphs with fewer than approximately 20 vertices. In this paper, we design reversible irreducible Markov chains on the space of Markov equivalent classes by proposing a perfect set of operators that determine the transitions of the Markov chain. The stationary distribution of a proposed Markov chain has a closed form and can be computed easily. Specifically, we construct a concrete perfect set of operators on sparse Markov equivalence classes by introducing appropriate conditions on each possible operator. Algorithms and their accelerated versions are provided to efficiently generate Markov chains and to explore properties of Markov equivalence classes of sparse directed acyclic graphs (DAGs) with thousands of vertices. We find experimentally that in most Markov equivalence classes of sparse DAGs, (1) most edges are directed, (2) most undirected subgraphs are small and (3) the number of these undirected subgraphs grows approximately linearly with the number of vertices.",
        "keywords": [
            "Sparse graphical model",
            "reversible Markov chain",
            "Markov equivalence class",
            "Causal inference"
        ],
        "authors": [
            {
                "name": "Yangbo He",
                "org": "Peking Univ, Sch Math Sci, Beijing 100871, Peoples R China"
            },
            {
                "name": "Jinzhu Jia",
                "org": "Peking Univ, Sch Math Sci, Beijing 100871, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2013
    },
    "ul735obg": {
        "id": "ul735obg",
        "title": "Fusing information from MISR and MODIS for polar cloud detection",
        "abstract": "Clouds play a major role in controlling Earth's climate, and cloud detection is a crucial step in the numerical weather prediction, and global climate models. Multi-angle imaging spectroradiometer (MLSR) and moderate resolution imaging spectroradiometer (MODIS) were launched in 1999 by clouds. However, cloud detection algorithms using either MISR or MODIS data separately do not take full advantage of the data collected by both sensors. In this paper, we propose and test two schemes to combine MISR and MODIS data for cloud detection in polar regions, Both schemes are follow-ups of a two-step polar cloud detection algorithm using MISR data: enhanced linear correlation matching classification followed by quadratic discriminate analysis (ELMS-QDA) (T, Shi et al.). The first scheme is mapping the MODIS cloud detection results to the MISR grid based on a nearest neighbor method, then only reporting the agreed pixels of the ELCMC-QDA results (from MISR) and MODIS operational results. This scheme improves the classification accuracy, but reduces the coverage of the results. Instead of combining the MISR and MODIS results directly, the second scheme uses the agreed pixels of ELCMC results and MODIS operational results as the training data for the QDA on MISR features, and output the results from the QDA. Both schemes are tested over a region where expert labels show that both MISR and MODIS operational algorithms do not work well (according to expert labels, 53% and 12.72% misclassification rates for MISR and MODIS operational algorithms respectively). The first scheme only makes 0.72% of errors, but leaves 68.72% of pixels unclassified. The second scheme reaches a 2.93% of misclassification rate, which is smaller than a 4.09% rate from ELCMC-QDA, and it provides a full coverage. Hence we propose using QDA on ELCMC and MODIS agreed pixels as an algorithm to fuse the MISR and MODIS information for the polar cloud detection.",
        "keywords": [
            "global climate models",
            "atmospheric techniques",
            "image matching",
            "quadratic discriminate analysis",
            "multiangle imaging spectroradiometer",
            "image resolution",
            "numerical weather prediction",
            "enhanced linear correlation matching classification",
            "clouds",
            "image classification",
            "geophysical signal processing",
            "object detection",
            "radiometers",
            "polar cloud detection",
            "sensors",
            "moderate resolution imaging spectroradiometer",
            "data collection",
            "nearest neighbor method",
            "global climate model",
            "quadratic discriminant analysis"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Eugene Clothiaux",
                "org": ""
            },
            {
                "name": "Amy Braverman",
                "org": ""
            }
        ],
        "venue": "Signals, Systems and Computers, 2004. Conference Record of the Thirty-Eighth Asilomar Conference",
        "year": 2004
    },
    "zyA5ZA9z": {
        "id": "zyA5ZA9z",
        "title": "Grouped and Hierarchical Model Selection through Composite Absolute Penalties",
        "abstract": "Abstract",
        "keywords": [],
        "authors": [
            {
                "name": "Peng Zhao",
                "org": "Department of Statistics|University of California , Berkeley"
            },
            {
                "name": "Guilherme Rocha",
                "org": "Department of Statistics|University of California , Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics|University of California , Berkeley"
            }
        ],
        "venue": "",
        "year": 0
    },
    "CjMjEYmn": {
        "id": "CjMjEYmn",
        "title": "Looking at Markov samplers through cusum path plots: a simple diagnostic idea",
        "abstract": "In this paper, we propose to monitor a Markov chain sampler using the cusum path plot of a chosen one-dimensional summary statistic. We argue that the cusum path plot can bring out, more effectively than the sequential plot, those aspects of a Markov sampler which tell the user how quickly or slowly the sampler is moving around in its sample space, in the direction of the summary statistic. The proposal is then illustrated in four examples which represent situations where the cusum path plot works well and not well. Moreover, a rigorous analysis is given for one of the examples. We conclude that the cusum path plot is an effective tool for convergence diagnostics of a Markov sampler and for comparing different Markov samplers.",
        "keywords": [
            "Convergence diagnostic",
            "cusum path plot",
            "Markov sampler",
            "mixing",
            "sequential plot",
            "summary statistic"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California at Berkeley, Berkeley, CA 94720, USA"
            },
            {
                "name": "Per Mykland",
                "org": "Department of Statistics, University of Chicago, Chicago, IL 60637, USA"
            }
        ],
        "venue": "Statistics and Computing",
        "year": 1994
    },
    "ItJLVk7i": {
        "id": "ItJLVk7i",
        "title": "Early stopping and non-parametric regression: an optimal data-dependent stopping rule",
        "abstract": "Early stopping is a form of regularization based on choosing when to stop running an iterative algorithm. Focusing on non-parametric regression in a reproducing kernel Hilbert space, we analyze the early stopping strategy for a form of gradient-descent applied to the least-squares loss function. We propose a data-dependent stopping rule that does not involve hold-out or cross-validation data, and we prove upper bounds on the squared error of the resulting function estimate, measured in either the L2(P) and L2(Pn) norm. These upper bounds lead to minimax-optimal rates for various kernel classes, including Sobolev smoothness classes and other forms of reproducing kernel Hilbert spaces. We show through simulation that our stopping rule compares favorably to two other stopping rules, one based on hold-out data and the other based on Stein's unbiased risk estimate. We also establish a tight connection between our early stopping strategy and the solution path of a kernel ridge regression estimator.",
        "keywords": [
            "kernel ridge regression",
            "empirical processes",
            "reproducing kernel hilbert space",
            "rademacher complexity",
            "early stopping",
            "non-parametric regression",
            "stopping rule",
            "non parametric regression"
        ],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": "Department of Statistics, University of WisconsinMadison, Madison, WI"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Department of Statistics, University of California, Berkeley, CA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA"
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2014
    },
    "uAcrCtal": {
        "id": "uAcrCtal",
        "title": "Regularization in statistics",
        "abstract": "This paper is a selective review of the regularization methods scattered in statistics literature. We introduce a general\n conceptual approach to regularization and fit most existing methods into it. We have tried to focus on the importance of regularization\n when dealing with today's high-dimensional objects: data and models. A wide range of examples are discussed, including nonparametric\n regression, boosting, covariance matrix estimation, principal component estimation, subsampling.",
        "keywords": [
            "Regularization",
            "linear regression",
            "nonparametric regression",
            "boosting",
            "covariance matrix",
            "principal component",
            "bootstrap",
            "subsampling",
            "model selection",
            "Primary 62G08",
            "62H12",
            "Secondary 62F12",
            "62G20",
            "62H25"
        ],
        "authors": [
            {
                "name": "Peter J. Bickel",
                "org": "University of California at Berkeley Department of Statistics USA"
            },
            {
                "name": "Bo Li",
                "org": "Tsinghua University School of Economics and Management China"
            },
            {
                "name": "Alexandre B. Tsybakov",
                "org": "Université Paris VI Laboratoire de Probabilités et Modèles Aléatoires France"
            },
            {
                "name": "Sara A. van de Geer",
                "org": "ETH Zürich Seminar für Statistik Switzerland"
            },
            {
                "name": "Bin Yu",
                "org": "University of California at Berkeley Department of Statistics USA"
            },
            {
                "name": "Teófilo Valdés",
                "org": "Complutense University of Madrid Department of Statistics and Operational Research Spain"
            },
            {
                "name": "Carlos Rivero",
                "org": "Complutense University of Madrid Department of Statistics and Operational Research Spain"
            },
            {
                "name": "Jianqing Fan",
                "org": "Princeton University Department of Operations Research and Financial Engineering USA"
            },
            {
                "name": "Aad van der Vaart",
                "org": "Vrije Universiteit Amsterdam Department of Mathematics Netherlands"
            }
        ],
        "venue": "Test",
        "year": 2006
    },
    "tqNlJ8HB": {
        "id": "tqNlJ8HB",
        "title": "Topics in random forests",
        "abstract": "Random Forests has become increasingly popular in Machine Learning. It is regarded as one of the best off-the-shelf classifiers. This dissertation contributes to further study and improve the Random Forest algorithm and applies it to the field of drug discovery. It consists of three loosely related topics on Random Forests. It is motivated by several problems the author came across when doing internships and research on Random Forests in the pharmaceutical industry and finance industry. The first part develops a sequential screening procedure based on Random Forests for biochemistry labs in search of drug discovery. We show its effectiveness in searching active compounds compared with a traditional two rounds procedure. We further compare our Random Forests sequential screening procedure with the sequential screening procedures based on two other most promising classification machines for QSAR modeling: Support Vector Machine and Binary Kernel discrimination, and show favorable results. The second part strives to improve the Random Forests classifier, making it able to handle Unbalanced classification, i.e., at least one of the classes constitutes only a very small minority of the data. Two methods of learning imbalanced data based on Random Forests are proposed. We compare their prediction performance with existing methods on some benchmark data sets and show favorable results. We further extend the idea of dealing with imbalanced data to Support Vector Machine. The two most accurate classification machines to date are compared in their ability to learn imbalanced data. The last part aims at making exploratory research on unsupervised learning with Random Forests. We present how the Random Forests proximity measure can be derived in the unsupervised learning setting, and further study its performance when applied to cluster analysis and multidimensional scaling.",
        "keywords": [
            "Support Vector Machine",
            "Random Forest algorithm",
            "benchmark data set",
            "Machine Learning",
            "Random Forests",
            "Random Forests classifier",
            "drug discovery",
            "imbalanced data",
            "favorable result",
            "sequential screening procedure",
            "random forest"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            },
            {
                "name": "Chao Chen",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "Topics in random forests",
        "year": 2005
    },
    "PIlKe5wu": {
        "id": "PIlKe5wu",
        "title": "Frontiers in Nonparametric Statistics",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peter buhlmann",
                "org": ""
            },
            {
                "name": "tony cai",
                "org": ""
            },
            {
                "name": "axel munk",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Oberwolfach Reports",
        "year": 2012
    },
    "HDW4J4N9": {
        "id": "HDW4J4N9",
        "title": "Binning in Gaussian Kernel Regularization",
        "abstract": "Gaussian kernel regularization is widely used in the machine learning literature and proven successful in many empirical experiments. The periodic version of the Gaussian kernel reg- ularization has been shown to be minimax rate optimal in estimating functions in any flnite order Sobolev spaces. However, for a data set with n points, the computation complexity of the Gaussian kernel regularization method is of order O(n3). In this paper we propose to use binning to reduce the computation of Gaussian kernel regularization in both regression and classiflcation. For the periodic Gaussian kernel regression, we show that the binned estimator achieves the same minimax rates of the unbinned estimator, but the computation is reduced to O(m3) with m as the number of bins. To achieve the minimax rate in the k-th order Sobolev space, m needs to be in the order of O(kn1=(2k+1)), which makes the binned estimator computation of order O(n) for k = 1 and even less for larger k. Our simulations show that the binned estimator (binning 120 data points into 20 bins in our simulation) provides almost the same accuracy with only 0.4% of computation time. For classiflcation, binning with the L2-loss Gaussian kernel regularization and the Gaussian kernel Support Vector Machines is tested in a polar cloud detection problem. With basically the same computation time, the L2-loss Gaussian kernel regularization on 966 bins achieves better test classiflcation rate (79.22%) than that (71.40%) on 966 randomly sampled data. Using the OSU-SVM Matlab package, the SVM trained on 966 bins has a comparable test classiflcation rate as the SVM trained on 27,179 samples, but reduces the training time from 5.99 hours to 2.56 minutes. The SVM trained on 966 randomly selected samples has a similar training time as and a slightly worse test classiflcation rate than the SVM on 966 bins, but has 67% more",
        "keywords": [
            "gaussian kernel",
            "binning",
            "rate of convergence",
            "sobolev space",
            "asymptotic minimax risk",
            "support vector machines.",
            "regularization",
            "sampling",
            "gaussian quadrature",
            "support vector machine",
            "classification",
            "data bases",
            "computations",
            "machine learning",
            "computational complexity"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": "Ohio State University|University of California at Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics|University of California"
            }
        ],
        "venue": "",
        "year": 2006
    },
    "ywzsL2bO": {
        "id": "ywzsL2bO",
        "title": "Lasso adjustments of treatment effect estimates in randomized experiments",
        "abstract": "We provide a principled way for investigators to analyze randomized experiments when the number of covariates is large. Investigators often use linear multivariate regression to analyze randomized experiments instead of simply reporting the difference of means between treatment and control groups. Their aim is to reduce the variance of the estimated treatment effect by adjusting for covariates. If there are a large number of covariates relative to the number of observations, regression may perform poorly because of overfitting. In such cases, the least absolute shrinkage and selection operator (Lasso) may be helpful. We study the resulting Lasso-based treatment effect estimator under the Neyman–Rubin model of randomized experiments. We present theoretical conditions that guarantee that the estimator is more efficient than the simple difference-of-means estimator, and we provide a conservative estimator of the asymptotic variance, which can yield tighter confidence intervals than the difference-of-means estimator. Simulation and data examples show that Lasso-based adjustment can be advantageous even when the number of covariates is less than the number of observations. Specifically, a variant using Lasso for selection and ordinary least squares (OLS) for estimation performs particularly well, and it chooses a smoothing parameter based on combined performance of Lasso and OLS.",
        "keywords": "",
        "authors": [
            {
                "name": "Adam Bloniarz",
                "org": "aDepartment of Statistics, University of California, Berkeley, CA 94720;"
            },
            {
                "name": "Hanzhong Liu",
                "org": "aDepartment of Statistics, University of California, Berkeley, CA 94720;"
            },
            {
                "name": "Cun-Hui Zhang",
                "org": "bDepartment of Statistics and Biostatistics, Rutgers University, Piscataway, NJ 08854;"
            },
            {
                "name": "Jasjeet S. Sekhon",
                "org": "aDepartment of Statistics, University of California, Berkeley, CA 94720;"
            },
            {
                "name": "Bin Yu",
                "org": "aDepartment of Statistics, University of California, Berkeley, CA 94720;"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2016
    },
    "nrOwUF9j": {
        "id": "nrOwUF9j",
        "title": "Distributed modal identification using restricted auto regressive models",
        "abstract": "Advances in Wireless Sensor Networks (WSN) technology have provided promising possibilities in detecting a change in the state of a structure through monitoring its features estimated using sensor data. The natural vibration properties of the structure are a set of features commonly used for this purpose and are often estimated using a multivariate autoregressive model (AR model) for the measured structure's response to ambient vibrations. Fitting a multivariate AR model to the observed acceleration requires the computation of the lagged covariance between the measurements in all nodes. The resulting volume of data transmission causes significant latency due to the low data bandwidth of WSNs in addition to having a high transmission energy cost. In this paper, a set of restrictions to the estimation of the AR model is introduced. Such restrictions significantly reduce the volume of data flowing through the WSN thus reducing the latency in obtaining modal parameters and extending the battery lifetime of the WSN. A physical motivation is given for the restrictions based on a linear model for a multi-degree of freedom vibrating system. Stabilisation diagrams are compared for the restricted and full AR models fitted using data simulated from linear structures and real data collected from a WSN deployed on the Golden Gate Bridge (GGB). These stabilisation diagrams show that the estimated modes using the restricted AR models are of comparable quality to that of the full AR model while substantially reducing the volume of transmitted data.",
        "keywords": [
            "stabilisation diagram",
            "full ar model",
            "regressive model",
            "low data bandwidth",
            "transmitted data",
            "restricted auto",
            "modal identification",
            "multivariate ar model",
            "linear model",
            "sensor data",
            "data transmission",
            "ar model",
            "wireless sensor networks",
            "distributed processing"
        ],
        "authors": [
            {
                "name": "Shamim N. Pakzad",
                "org": "Department of Civil and Environmental Engineering, Lehigh University, Bethlehem, USA"
            },
            {
                "name": "Guilherme V. Rocha",
                "org": "Department of Statistics, Indiana University, Bloomington, USA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, USA"
            }
        ],
        "venue": "International Journal of Systems Science",
        "year": 2011
    },
    "q5IzvoxX": {
        "id": "q5IzvoxX",
        "title": "Nonparametric sparse hierarchical models describe V1 fMRI responses to natural images",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Pradeep Ravikumar",
                "org": ""
            },
            {
                "name": "Vincent Q. Vu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Thomas Naselaris",
                "org": ""
            },
            {
                "name": "Kendrick Kay",
                "org": ""
            },
            {
                "name": "Jack L. Gallant",
                "org": ""
            }
        ],
        "venue": "NIPS",
        "year": 2008
    },
    "cBIZFcAC": {
        "id": "cBIZFcAC",
        "title": "Boosting with the L_2-Loss: Regression and Classification",
        "abstract": " This paper investigates a computationally simple variant of boosting, L 2 Boost,which is constructed from a functional gradient descent algorithm with the L 2 -lossfunction. As other boosting algorithms, L 2 Boost uses many times in an iterativefashion a pre-chosen fitting method, called the learner. Based on the explicit expressionof refitting of residuals of L 2 Boost, the case with (symmetric) linear learners isstudied in detail in both regression and classification. In particular, ... ",
        "keywords": [],
        "authors": [
            {
                "name": "Peter Bühlmann",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "7yn8UhQK": {
        "id": "7yn8UhQK",
        "title": "Multi-Task Sparse Discriminant Analysis (MtSDA) with Overlapping Categories",
        "abstract": "Multi-task learning aims at combining information across tasks to boost prediction performance, especially when the number of training samples is small and the number of predic- tors is very large. In this paper, we first extend the Sparse Dis- criminate Analysis (SDA) of Clemmensen et al.. We call this Multi-task Sparse Discriminate Analysis (MtSDA). MtSDA formulates multi-label prediction as a quadratic optimization problem whereas SDA obtains single labels via a nearest class mean rule. Second, we propose a class of equicorrelation matrices to use in MtSDA which includes the identity ma- trix. MtSDA with both matrices are compared with single- task learning (SVM and LDA+SVM) and multi-task learning (HSML). The comparisons are made on real data sets in terms of AUC and F-measure. The data results show that MtSDA outperforms other methods substantially almost all the time and in some cases MtSDA with the equicorrelation matrix substantially outperforms MtSDA with identity matrix .",
        "keywords": [
            "multi task learning",
            "quadratic optimization",
            "discriminant analysis"
        ],
        "authors": [
            {
                "name": "Yahong Han",
                "org": "zhejiang university"
            },
            {
                "name": "Fei Wu",
                "org": "zhejiang university"
            },
            {
                "name": "Jinzhu Jia",
                "org": "university of california berkeley"
            },
            {
                "name": "Yueting Zhuang",
                "org": "zhejiang university"
            },
            {
                "name": "Bin Yu",
                "org": "university of california berkeley"
            }
        ],
        "venue": "AAAI",
        "year": 2010
    },
    "eucU0Ya9": {
        "id": "eucU0Ya9",
        "title": "Concise comparative summaries (CCS) of large text corpora with a human experiment.",
        "abstract": "In this paper we propose a general framework for topic-specific summarization of large text corpora and illustrate how it can be used for the analysis of news databases. Our framework, concise comparative summarization (CCS), is built on sparse classification methods. CCS is a lightweight and flexible tool that offers a compromise between simple word frequency based methods currently in wide use and more heavyweight, model-intensive methods such as latent Dirichlet allocation (LDA). We argue that sparse methods have much to offer for text analysis and hope CCS opens the door for a new branch of research in this important field. For a particular topic of interest (e.g., China or energy), CSS automatically labels documents as being either on-or off-topic (usually via keyword search), and then uses sparse classification methods to predict these labels with the high-dimensional counts of all the other words and phrases in the documents. The resulting small set of phrases found as predictive are then harvested as the summary. To validate our tool, we, using news articles from the New York Times international section, designed and conducted a human survey to compare the different summarizers with human understanding. We demonstrate our approach with two case studies, a media analysis of the framing of \"Egypt\" in the New York Times throughout the Arab Spring and an informal comparison of the New York Times' and Wall Street Journal's coverage of \"energy.\" Overall, we find that the Lasso with L-2 normalization can be effectively and usefully used to summarize large corpora, regardless of document size.",
        "keywords": [
            "Text summarization",
            "high-dimensional analysis",
            "sparse modeling",
            "Lasso",
            "L1 regularized logistic regression",
            "co-occurrence",
            "tf-idf",
            "L2 normalization"
        ],
        "authors": [
            {
                "name": "Jinzhu Jia",
                "org": "Peking Univ, Sch Math Sci, LMAM, Beijing 100871, Peoples R China"
            },
            {
                "name": "Luke Miratrix",
                "org": "Harvard Univ, Dept Stat, Cambridge, MA 02138 USA"
            },
            {
                "name": "Bin Yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            },
            {
                "name": "Brian Gawalt",
                "org": "Univ Calif Berkeley, Dept EECS, Berkeley, CA 94720 USA"
            },
            {
                "name": "Laurent El Ghaoui",
                "org": "Univ Calif Berkeley, Dept EECS, Berkeley, CA 94720 USA"
            },
            {
                "name": "Luke Barnesmoore",
                "org": "San Francisco State Univ, Coll Liberal & Creat Arts, Dept Int Relat, San Francisco, CA 94132 USA"
            },
            {
                "name": "Sophie Clavier",
                "org": "San Francisco State Univ, Coll Liberal & Creat Arts, Dept Int Relat, San Francisco, CA 94132 USA"
            }
        ],
        "venue": "ANNALS OF APPLIED STATISTICS",
        "year": 2014
    },
    "PAY4U8il": {
        "id": "PAY4U8il",
        "title": "Fast mixing of Metropolized Hamiltonian Monte Carlo: Benefits of multi-step gradients.",
        "abstract": "  Hamiltonian Monte Carlo (HMC) is a state-of-the-art Markov chain Monte Carlo sampling algorithm for drawing samples from smooth probability densities over continuous spaces. We study the variant most widely used in practice, Metropolized HMC with the St\\\"{o}rmer-Verlet or leapfrog integrator, and make two primary contributions. First, we provide a non-asymptotic upper bound on the mixing time of the Metropolized HMC with explicit choices of stepsize and number of leapfrog steps. This bound gives a precise quantification of the faster convergence of Metropolized HMC relative to simpler MCMC algorithms such as the Metropolized random walk, or Metropolized Langevin algorithm. Second, we provide a general framework for sharpening mixing time bounds Markov chains initialized at a substantial distance from the target distribution over continuous spaces. We apply this sharpening device to the Metropolized random walk and Langevin algorithms, thereby obtaining improved mixing time bounds from a non-warm initial distribution. ",
        "keywords": "",
        "authors": [
            {
                "name": "Yuansi Chen",
                "org": ""
            },
            {
                "name": "Raaz Dwivedi",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Machine Learning",
        "year": 2019
    },
    "T3hhwdk9": {
        "id": "T3hhwdk9",
        "title": "Preface",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Alexandre d’Aspremont",
                "org": "Princeton University, ORFE Department, 08544, Princeton, NJ, USA"
            },
            {
                "name": "Francis Bach",
                "org": "Laboratoire d’Informatique de l’Ecole Normale Supérieure, INRIA  Willow project, Paris, France"
            },
            {
                "name": "Inderjit S. Dhillon",
                "org": "University of Texas at Austin, Department of Computer Sciences, Austin, TX, USA"
            },
            {
                "name": "Bin Yu",
                "org": "UC Berkeley, Department of Statistics, Department of Electrical Engineering & Computer Science, Berkeley, CA, USA"
            }
        ],
        "venue": "Mathematical Programming: Series A and B - Special Issue on \\\"Optimization and Machine learning\\\"; Alexandre d’Aspremont • Francis Bach • Inderjit S. Dhillon • Bin Yu",
        "year": 2011
    },
    "TueSSn7N": {
        "id": "TueSSn7N",
        "title": "Embracing Statistical Challenges in the Information Technology Age",
        "abstract": "This article examines the role of statistics in the age of information technology (IT). It begins by examining the current state of IT and of the cyberinfrastructure initiative aimed at integrating the technologies into science, engineering, and education to convert massive amounts of data into useful information. Selected applications from science and text processing are introduced to provide concrete examples of massive data sets and the statistical challenges that they pose. The thriving field of machine learning is reviewed as an example of current achievements driven by computations and IT. Ongoing challenges that we face in the IT revolution are also highlighted. The paper concludes that for the healthy future of our field, computer technologies have to be integrated into statistics, and statistical thinking in turn must be integrated into computer technologies.",
        "keywords": [
            "data acquisition",
            "data processing",
            "statistical analysis",
            "information retrieval",
            "machine learning",
            "feature extraction",
            "tomography",
            "age",
            "information technology",
            "computations",
            "statistics",
            "artificial intelligence",
            "teaching"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Statistics|University of California at Berkeley"
            }
        ],
        "venue": "Technometrics",
        "year": 2007
    },
    "mmjoP9uQ": {
        "id": "mmjoP9uQ",
        "title": "Stability and Convergence Trade-off of Iterative Optimization Algorithms.",
        "abstract": "The overall performance or expected excess risk of an iterative machine learning algorithm can be decomposed into training error and generalization error. While the former is controlled by its convergence analysis, the latter can be tightly handled by algorithmic stability. The machine learning community has a rich history investigating convergence and stability separately. However, the question about the trade-off between these two quantities remains open. In this paper, we show that for any iterative algorithm at any iteration, the overall performance is lower bounded by the minimax statistical error over an appropriately chosen loss function class. This implies an important trade-off between convergence and stability of the algorithm -- a faster converging algorithm has to be less stable, and vice versa. As a direct consequence of this fundamental tradeoff, new convergence lower bounds can be derived for classes of algorithms constrained with different stability bounds. In particular, when the loss function is convex (or strongly convex) and smooth, we discuss the stability upper bounds of gradient descent (GD) and stochastic gradient descent and their variants with decreasing step sizes. For Nesterovu0027s accelerated gradient descent (NAG) and heavy ball method (HB), we provide stability upper bounds for the quadratic loss function. Applying existing stability upper bounds for the gradient methods in our trade-off framework, we obtain lower bounds matching the well-established convergence upper bounds up to constants for these algorithms and conjecture similar lower bounds for NAG and HB. Finally, we numerically demonstrate the tightness of our stability bounds in terms of exponents in the rate and also illustrate via a simulated logistic regression problem that our stability bounds reflect the generalization errors better than the simple uniform convergence bounds for GD and NAG.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuansi Chen",
                "org": ""
            },
            {
                "name": "Chi Jin",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "arXiv: Machine Learning",
        "year": 2018
    },
    "CC3FmHTr": {
        "id": "CC3FmHTr",
        "title": "Model Selection in Gaussian Graphical Models: High-Dimensional Consistency of l1-regularized MLE",
        "abstract": "We consider the problem of estimating the graph structure associated with a Gaussian Markov random field (GMRF) from i.i.d. samples. We study the p erformance of study the performance of the ℓ1-regularized maximum likelihood estimator in the high-dimensional setting, where the number of nodes in the graph p, the number of edges in the graph s and the maximum node degree d, are allowed to grow as a function of the number of samples n. Our main result provides sufficient conditions on (n, p, d) for the ℓ1-regularized MLE estimator to recover all the edges of the graph with high probability. Under some conditions on the model covariance, we show that model selection can be achieved for sample sizes n = (d2 log(p)), with the error decaying as O(exp( clog(p))) for some constant c. We illustrate our theoretical results via simulations and sho w good correspondences between the theoretical predictions and behavior in simulations. The area of high-dimensional statistics deals with estimat ion in the \"large p, small n\" setting, where p and n correspond, respectively, to the dimensionality of the dat a and the sample size. Such high- dimensional problems arise in a variety of applications, among them remote sensing, computational biology and natural language processing, where the model dimension may be comparable or sub- stantially larger than the sample size. It is well-known tha t such high-dimensional scaling can lead to dramatic breakdowns in many classical procedures. In the absence of additional model assumptions, it is frequently impossible to obtain consistent procedure s when p ≫ n. Accordingly, an active line of statistical research is based on imposing various restri ctions on the model—-for instance, spar- sity, manifold structure, or graphical model structure—-and then studying the scaling behavior of different estimators as a function of sample size n, ambient dimension p and additional parameters related to these structural assumptions. In this paper, we study the problem of estimating the graph structure of a Gauss Markov random field (GMRF) in the high-dimensional setting. This graphical model selection problem can be reduced to the problem of estimating the zero-pattern of the inverse covariance or concentration matrix �∗. A line of recent work (1, 2, 3, 4) has studied estimators based on minimizing Gaussian log-likelihood penalized by the ℓ1 norm of the entries (or the off-diagonal entries) of the conc entration matrix. The resulting optimization problem is a log-determinant program, which can be solved in polynomial time with interior point methods (5), or by faster co-ordina te descent algorithms (3, 4). In recent work, Rothman et al. (1) have analyzed some aspects of high-dimensional behavior, in particular establishing consistency in Frobenius norm under certain conditions on the model covariance and under certain scalings of the sparsity, sample size, and ambient model dimension.",
        "keywords": [],
        "authors": [
            {
                "name": "Pradeep Ravikumar",
                "org": ""
            },
            {
                "name": "Garvesh Raskutti",
                "org": ""
            },
            {
                "name": "Martin Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "NIPS",
        "year": 2008
    },
    "u15OWrUK": {
        "id": "u15OWrUK",
        "title": "Supplement to \"Reversible MCMC on Markov equivalence classes of sparse directed acyclic graphs\"",
        "abstract": "  This supplementary material includes three parts: some preliminary results, four examples, an experiment, three new algorithms, and all proofs of the results in the paper \"Reversible MCMC on Markov equivalence classes of sparse directed acyclic graphs\". ",
        "keywords": [],
        "authors": [
            {
                "name": "yangbo he",
                "org": ""
            },
            {
                "name": "jinzhu jia",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "PyWloBRQ": {
        "id": "PyWloBRQ",
        "title": "Geometry of the faithfulness assumption in causal inference",
        "abstract": "Many algorithms for inferring causality rely heavily on the faithfulness assumption. The main justification for imposing this assumption is that the set of unfaithful distributions has Lebesgue measure zero, since it can be seen as a collection of hypersurfaces in a hypercube. However, due to sampling error the faithfulness condition alone is not sufficient for statistical estimation, and strong-faithfulness has been proposed and assumed to achieve uniform or high-dimensional consistency. In contrast to the plain faithfulness assumption, the set of distributions that is not strong-faithful has nonzero Lebesgue measure and in fact, can be surprisingly large as we show in this paper. We study the strong-faithfulness condition from a geometric and combinatorial point of view and give upper and lower bounds on the Lebesgue measure of strong-faithful distributions for various classes of directed acyclic graphs. Our results imply fundamental limitations for the PC-algorithm and potentially also for other algorithms based on partial correlation testing in the Gaussian case.",
        "keywords": [
            "Causal inference",
            "PC-algorithm",
            "(strong) faithfulness",
            "conditional independence",
            "directed acyclic graph",
            "structural equation model",
            "real algebraic hypersurface",
            "Crofton's formula",
            "algebraic statistics"
        ],
        "authors": [
            {
                "name": "caroline uhler",
                "org": "IST Austria, A-3400 Klosterneuburg, Austria"
            },
            {
                "name": "garvesh raskutti",
                "org": "SAMSI, Res Triangle Pk, NC 27709 USA"
            },
            {
                "name": "peter buhlmann",
                "org": "ETH, Seminar Stat, CH-8092 Zurich, Switzerland"
            },
            {
                "name": "bin yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2012
    },
    "oN3gnQT8": {
        "id": "oN3gnQT8",
        "title": "Supervised feature selection in graphs with path coding penalties and network flows",
        "abstract": "We consider supervised learning problems where the features are embedded in a graph, such as gene expressions in a gene network. In this context, it is of much interest to automatically select a subgraph with few connected components; by exploiting prior knowledge, one can indeed improve the prediction performance or obtain results that are easier to interpret. Regularization or penalty functions for selecting features in graphs have recently been proposed, but they raise new algorithmic challenges. For example, they typically require solving a combinatorially hard selection problem among all connected subgraphs. In this paper, we propose computationally feasible strategies to select a sparse and well-connected subset of features sitting on a directed acyclic graph (DAG). We introduce structured sparsity penalties over paths on a DAG called \\\"path coding\\\" penalties. Unlike existing regularization functions that model long-range interactions between features in a graph, path coding penalties are tractable. The penalties and their proximal operators involve path selection problems, which we efficiently solve by leveraging network flow optimization. We experimentally show on synthetic, image, and genomic data that our approach is scalable and leads to more connected subgraphs than other regularization functions for graphs.",
        "keywords": [
            "combinatorially hard selection problem",
            "path selection problem",
            "gene expression",
            "gene network",
            "connected component",
            "network flow optimization",
            "path coding",
            "regularization function",
            "connected subgraphs",
            "supervised feature selection",
            "acyclic graph"
        ],
        "authors": [
            {
                "name": "Julien Mairal",
                "org": "INRIA Grenoble Rhône-Alpes, France and Department of Statistics, University of California, Berkeley, CA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA and Department of Electrical Engineering & Computer Science"
            }
        ],
        "venue": "The Journal of Machine Learning Research",
        "year": 2013
    },
    "GDdtwmXx": {
        "id": "GDdtwmXx",
        "title": "Changepoint Analysis for Efficient Variant Calling.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Adam Bloniarz",
                "org": ""
            },
            {
                "name": "Ameet Talwalkar",
                "org": ""
            },
            {
                "name": "Jonathan Terhorst",
                "org": ""
            },
            {
                "name": "Michael I. Jordan",
                "org": ""
            },
            {
                "name": "David A. Patterson",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Yun S. Song",
                "org": ""
            }
        ],
        "venue": "RECOMB",
        "year": 2014
    },
    "1C1l0LUd": {
        "id": "1C1l0LUd",
        "title": "Boosting with the L2-loss",
        "abstract": "",
        "keywords": [
            "smoothing spline",
            "logitboost",
            "nonparametric regression"
        ],
        "authors": [
            {
                "name": "peter buhlmann",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Journal of the American Statistical Association",
        "year": 2001
    },
    "F8kshmuD": {
        "id": "F8kshmuD",
        "title": "Restricted Eigenvalue Properties for Correlated Gaussian Designs",
        "abstract": "Methods based on l1-relaxation, such as basis pursuit and the Lasso, are very popular for sparse regression in high dimensions. The conditions for success of these methods are now well-understood: (1) exact recovery in the noiseless setting is possible if and only if the design matrix X satisfies the restricted nullspace property, and (2) the squared l2-error of a Lasso estimate decays at the minimax optimal rate k log p / n, where k is the sparsity of the p-dimensional regression problem with additive Gaussian noise, whenever the design satisfies a restricted eigenvalue condition. The key issue is thus to determine when the design matrix X satisfies these desirable properties. Thus far, there have been numerous results showing that the restricted isometry property, which implies both the restricted nullspace and eigenvalue conditions, is satisfied when all entries of X are independent and identically distributed (i.i.d.), or the rows are unitary. This paper proves directly that the restricted nullspace and eigenvalue conditions hold with high probability for quite general classes of Gaussian matrices for which the predictors may be highly dependent, and hence restricted isometry conditions can be violated with high probability. In this way, our results extend the attractive theoretical guarantees on l1-relaxations to a much broader class of problems than the case of completely independent or unitary designs.",
        "keywords": [
            "gaussian comparison inequality",
            "design matrix x",
            "high probability",
            "gaussian matrix",
            "basis pursuit",
            "random matrix theory",
            "high dimension",
            "restricted isometry property",
            "restricted nullspace property",
            "restricted eigenvalue condition",
            "unitary design",
            "correlated gaussian designs",
            "restricted eigenvalue properties",
            "restricted nullspace",
            "concen- tration of measure",
            "lasso",
            "eigenvalue condition",
            "eigenvalues",
            "gaussian noise",
            "independent and identically distributed",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Garvesh Raskutti",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2010
    },
    "3TNhRu4Z": {
        "id": "3TNhRu4Z",
        "title": "Analyzing bagging",
        "abstract": "Bagging is one of the most effective computationally intensive procedures to im- prove on unstable estimators or classifiers, useful especially for high dimensional data set problems. Here we formalize the notion of instability and derive theoretical results to analyze the variance reduction effect of bagging (or its variant) in mainly hard decision problems, which include estimation after testing in regression and decision trees for continuous regression functions and classifiers. Hard decisions create insta- bility, and bagging is shown to smooth such hard decisions yielding smaller variance and mean squared error. With theoretical explanations, we motivate subagging based on subsampling as an alternative aggregation scheme. It is computationally cheaper but still showing approximately the same accuracy as bagging. Moreover, our theory reveals improvements in first order and in line with simulation studies. In particular, we obtain an asymptotic limiting distribution at the cube-root rate for the split point when fitting piecewise constant functions. Denoting sample size by n, it follows that in a cylindric neighborhood of diameter n 1/3 of the theoretically optimal split point, the variance and mean squared error reduction of subagging can be characterized analytically. Because of the slow rate, our reasoning also provides an explanation on the global scale for the whole covariate space in a decision tree with finitely many splits.",
        "keywords": [
            "nonparametric regression. 927",
            "multiple predictions",
            "mars",
            "classification",
            "decision tree",
            ". bootstrap",
            "model selection"
        ],
        "authors": [
            {
                "name": "Peter Bühlmann",
                "org": "ETH Zurich|University of California at Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "University of California , Berkeley"
            }
        ],
        "venue": "Annals of Statistics",
        "year": 2002
    },
    "rKePqGit": {
        "id": "rKePqGit",
        "title": "Fast MCMC Sampling Algorithms on Polytopes.",
        "abstract": "We propose and analyze two new MCMC sampling algorithms, the Vaidya walk and the John walk, for generating samples from the uniform distribution over a polytope. Both random walks are sampling algorithms derived from interior point methods. The former is based on volumetric-logarithmic barrier introduced by Vaidya whereas the latter uses Johnu0027s ellipsoids. We show that the Vaidya walk mixes in significantly fewer steps than the logarithmic-barrier based Dikin walk studied in past work. For a polytope in ℝd defined by n ≥ d linear constraints, we show that the mixing time from a warm start is bounded as O(n0.5d1.5), compared to the O(nd) mixing time bound for the Dikin walk. The cost of each step of the Vaidya walk is of the same order as the Dikin walk, and at most twice as large in terms of constant pre-factors. For the John walk, we prove an O(d2.5  log4(n/d) bound on its mixing time and conjecture that an improved variant of it could achieve a mixing time of O(d2  poly-log(n/d)). Additionally, we propose variants of the Vaidya and John walks that mix in polynomial time from a deterministic starting point. The speed-up of the Vaidya walk over the Dikin walk are illustrated in numerical examples.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuansi Chen",
                "org": "Department of Statistics, University of California, Berkeley, Berkeley#TAB#"
            },
            {
                "name": "Raaz Dwivedi",
                "org": "Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley#TAB#"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "Department of Statistics, Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley and Voleon Group#TAB#"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley#TAB#"
            }
        ],
        "venue": "Journal of Machine Learning Research",
        "year": 2018
    },
    "VtnsNTgo": {
        "id": "VtnsNTgo",
        "title": "SBA-term: Sparse Bilingual Association for Terms",
        "abstract": "Bilingual semantic term association is very useful in cross-language information retrieval, statistical machine translation, and many other applications in natural language processing. In this paper, we present a method, named SBA-term, which applies sparse linear regression (Lasso, Least Squares with l1 penalty) and L2 rescaling for design matrix to the task of bilingual term association. The approach hinges on formulating the task as a feature selection problem within a classification framework. Our experimental results indicate that our novel proposed method is more efficient than co-occurrence at extracting relevant bilingual terms semantic associations. In addition, our approach connects the vibrant area of sparse machine learning to an important problem of natural language processing.",
        "keywords": [
            "cross-language information retrieval",
            "learning (artificial intelligence)",
            "regression analysis",
            "sparse linear regression",
            "information retrieval",
            "statistical machine translation",
            "sba-term",
            "language translation",
            "semantic association",
            "bilingual semantic term association",
            "approach hinge",
            "sparse bilingual association",
            "bilingual term association",
            "important problem",
            "feature selection problem",
            "natural language processing",
            "machine learning",
            "sparse bilingual terms association",
            "relevant bilingual term",
            "sparse machine",
            "learning artificial intelligence"
        ],
        "authors": [
            {
                "name": "Xinyu Dai",
                "org": ""
            },
            {
                "name": "Jinzhu Jia",
                "org": ""
            },
            {
                "name": "Laurent El Ghaoui",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "ICSC",
        "year": 2011
    },
    "L0vPwo6U": {
        "id": "L0vPwo6U",
        "title": "Three papers on boosting: an introduction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Vladimir Koltchinskii",
                "org": ""
            }
        ],
        "venue": "Annals of Statistics",
        "year": 2003
    },
    "r2hDFPDm": {
        "id": "r2hDFPDm",
        "title": "GROUPED AND HIERARCHICAL VARIABLE SELECTION",
        "abstract": "",
        "keywords": [
            "and phrases: linear regression",
            "hierarchical models 1",
            "grouped selection",
            "penalized regression",
            "coef- ficient paths",
            "variable selection",
            "hierarchical model",
            "group selection",
            "linear regression"
        ],
        "authors": [
            {
                "name": "Peng Zhao",
                "org": "University of California at Berkeley"
            },
            {
                "name": "Guilherme Rocha",
                "org": "University of California at Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "University of California at Berkeley"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "E0Pcw3hs": {
        "id": "E0Pcw3hs",
        "title": "Daytime Arctic Cloud Detection Based on Multi-Angle Satellite Data With Case Studies",
        "abstract": "",
        "keywords": [
            "feature selection",
            "classification",
            "clustering",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Eugene E Clothiaux",
                "org": ""
            },
            {
                "name": "Amy J Braverman",
                "org": ""
            }
        ],
        "venue": "Journal of The American Statistical Association",
        "year": 2008
    },
    "jNWEtqLr": {
        "id": "jNWEtqLr",
        "title": "A Unified Framework for High-Dimensional Analysis of M-Estimators with Decomposable Regularizers",
        "abstract": "  High-dimensional statistical inference deals with models in which the the number of parameters p is comparable to or larger than the sample size n. Since it is usually impossible to obtain consistent procedures unless $p/n\\rightarrow0$, a line of recent work has studied models with various types of low-dimensional structure, including sparse vectors, sparse and structured matrices, low-rank matrices and combinations thereof. In such settings, a general approach to estimation is to solve a regularized optimization problem, which combines a loss function measuring how well the model fits the data with some regularization function that encourages the assumed structure. This paper provides a unified framework for establishing consistency and convergence rates for such regularized M-estimators under high-dimensional scaling. We state one main theorem and show how it can be used to re-derive some existing results, and also to obtain a number of new results on consistency and convergence rates, in both $\\ell_2$-error and related norms. Our analysis also identifies two key properties of loss and regularization functions, referred to as restricted strong convexity and decomposability, that ensure corresponding regularized M-estimators have fast convergence rates and which are optimal in many well-studied cases. ",
        "keywords": [
            "nuclear norm",
            "high dimensional statistics",
            "m estimator",
            "lasso",
            "sparsity"
        ],
        "authors": [
            {
                "name": "sahand negahban",
                "org": ""
            },
            {
                "name": "pradeep ravikumar",
                "org": ""
            },
            {
                "name": "martin j wainwright",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Statistical Science",
        "year": 2010
    },
    "vJM8V5QP": {
        "id": "vJM8V5QP",
        "title": "Conifer species recognition: effects of data transformation",
        "abstract": "",
        "keywords": [
            "data transformation"
        ],
        "authors": [
            {
                "name": "peng gong",
                "org": ""
            },
            {
                "name": "ruiliang pu",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "International Journal of Remote Sensing",
        "year": 2001
    },
    "XU6ilrTf": {
        "id": "XU6ilrTf",
        "title": "On Model Selection Consistency of the Elastic Net When p >> n",
        "abstract": "In this paper, we study the model selection property of the Elastic net. In the classical settings when p (the number of predictors) and q (the number of predictors with non-zero coefficients in the true linear model) are fixed, Yuan and Lin (2007) give a necessary and sufficient condition for the Elastic net to consistently select the true model, which is called the Elastic Irrepresentable Condition (EIC) in this paper. Here we study the general case when p, q and n all go to infinity. For general scalings of p, q and n, when gaussian noise is assumed, sufficient conditions on p, q and n ar given in this paper such that EIC guarantees the Elastic net's model selection consistency. We show that to make these conditions hold, n should grow at a rate faster than q log(p q). For the classical case, when p and q are fixed, we also study the relationship between EIC and the Irrepresentable Condition (IC) which is necessary and sufficient for the Lasso to select the true model. Through theoretical results and simulation studies, we provide insights into when and why EIC is weaker than IC and when the Elastic net can consistently select the true model even when the Lasso can not.",
        "keywords": [
            "elastic irrepresentable condition.",
            "irrepre- sentable condition",
            "model selection consistency",
            "lasso",
            "elastic net"
        ],
        "authors": [
            {
                "name": "Jinzhu Jia",
                "org": "Peking University|University of California , Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "Peking University|University of California , Berkeley"
            }
        ],
        "venue": "",
        "year": 0
    },
    "tNoT3nBc": {
        "id": "tNoT3nBc",
        "title": "Hierarchical interpretations for neural network predictions.",
        "abstract": "Deep neural networks (DNNs) have achieved impressive predictive performance due to their ability to learn complex, non-linear relationships between variables. However, the inability to effectively visualize these relationships has led to DNNs being characterized as black boxes and consequently limited their applications. To ameliorate this problem, we introduce the use of hierarchical interpretations to explain DNN predictions through our proposed method, agglomerative contextual decomposition (ACD). Given a prediction from a trained DNN, ACD produces a hierarchical clustering of the input features, along with the contribution of each cluster to the final prediction. This hierarchy is optimized to identify clusters of features that the DNN learned are predictive. Using examples from Stanford Sentiment Treebank and ImageNet, we show that ACD is effective at diagnosing incorrect predictions and identifying dataset bias. Through human experiments, we demonstrate that ACD enables users both to identify the more accurate of two DNNs and to better trust a DNNu0027s outputs. We also find that ACDu0027s hierarchy is largely robust to adversarial perturbations, implying that it captures fundamental aspects of the input and ignores spurious noise.",
        "keywords": "",
        "authors": [
            {
                "name": "Chandan Singh",
                "org": "University of California, Berkeley"
            },
            {
                "name": "W. James Murdoch",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley"
            }
        ],
        "venue": "international conference on learning representations",
        "year": 2019
    },
    "Y522EYrt": {
        "id": "Y522EYrt",
        "title": "Pseudo likelihood estimation in network tomography",
        "abstract": "Network monitoring and diagnosis are key to improving network performance. The difficulties of performance monitoring lie in today's fast growing Internet, accompanied by increasingly heterogeneous and unregulated structures. Moreover, these tasks become even harder since one cannot rely on the collaboration of individual routers and servers to directly measure network traffic. Even though the aggregatory nature of possible network measurements gives rise to inverse problems, existing methods for solving inverse problems are usually computationally intractable or statistically inefficient. In this paper, a pseudo likelihood approach is proposed to solve a group of network tomography problems. The basic idea of pseudo likelihood is to form simple subproblems and construct a product of marginal likelihood of subproblems by the ignoring their dependences. As a result, it keeps a good balance between the computational complexity and the statistical efficiency of the parameter estimation. Some statistical properties of the pseudo likelihood estimator, such as consistency and asymptotic normality, are established. A pseudo expectation-maximization (EM) algorithm is developed to maximize the pseudo log-likelihood function. Two examples with simulated or real data are used to illustrate the pseudo likelihood proposal: (1) internal link delay distribution inference through multicast end-to-end measurements; (2) origin-destination matrix estimation through link traffic counts.",
        "keywords": [
            "multicast tree",
            "network performance monitoring",
            "statistical efficiency",
            "server",
            "network traffic",
            "tomography",
            "subproblem marginal likelihood",
            "pseudo log-likelihood function",
            "monitoring",
            "asymptotic normality",
            "parameter estimation",
            "network diagnosis",
            "network topology",
            "network traffic count",
            "inverse problems",
            "unregulated structure",
            "computational complexity",
            "internal link delay distribution",
            "inverse problem",
            "origin-destination matrix estimation",
            "internet",
            "statistical property",
            "pseudo likelihood estimation",
            "network tomography",
            "telecommunication network routing",
            "heterogeneous structure",
            "pseudo expectation-maximization algorithm",
            "router",
            "em algorithm",
            "multicast communication",
            "multicast end-to-end measurement",
            "indexing terms",
            "likelihood function",
            "marginal likelihood",
            "network monitoring",
            "expectation maximization",
            "network performance"
        ],
        "authors": [
            {
                "name": "Gang Liang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "INFOCOM",
        "year": 2003
    },
    "R8E9ARgH": {
        "id": "R8E9ARgH",
        "title": "Asymptotic Properties of Lasso+mLS and Lasso+Ridge in Sparse High-dimensional Linear Regression",
        "abstract": "  We study the asymptotic properties of Lasso+mLS and Lasso+Ridge under the sparse high-dimensional linear regression model: Lasso selecting predictors and then modified Least Squares (mLS) or Ridge estimating their coefficients. First, we propose a valid inference procedure for parameter estimation based on parametric residual bootstrap after Lasso+mLS and Lasso+Ridge. Second, we derive the asymptotic unbiasedness of Lasso+mLS and Lasso+Ridge. More specifically, we show that their biases decay at an exponential rate and they can achieve the oracle convergence rate of $s/n$ (where $s$ is the number of nonzero regression coefficients and $n$ is the sample size) for mean squared error (MSE). Third, we show that Lasso+mLS and Lasso+Ridge are asymptotically normal. They have an oracle property in the sense that they can select the true predictors with probability converging to 1 and the estimates of nonzero parameters have the same asymptotic normal distribution that they would have if the zero parameters were known in advance. In fact, our analysis is not limited to adopting Lasso in the selection stage, but is applicable to any other model selection criteria with exponentially decay rates of the probability of selecting wrong models. ",
        "keywords": [
            "sparsity",
            "lasso",
            "asymptotic normality"
        ],
        "authors": [
            {
                "name": "hanzhong liu",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "Electronic Journal of Statistics",
        "year": 2013
    },
    "yRI5VCbd": {
        "id": "yRI5VCbd",
        "title": "Statistical Recovery of Discrete, Geometric and Invariant Structures",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Peter Bühlmann",
                "org": "ETH Zentrum, Zürich, Switzerland"
            },
            {
                "name": "Axel Munk",
                "org": "Georg-August-Universität Göttingen, Germany"
            },
            {
                "name": "Martin J. Wainwright",
                "org": "University of California, Berkeley, USA"
            },
            {
                "name": "Bin Yu",
                "org": "University of California, Berkeley, USA"
            }
        ],
        "venue": "Oberwolfach Reports",
        "year": 2018
    },
    "AOgbhNeU": {
        "id": "AOgbhNeU",
        "title": "Optimal Subsampling Approaches for Large Sample Linear Regression",
        "abstract": "  A significant hurdle for analyzing large sample data is the lack of effective statistical computing and inference methods. An emerging powerful approach for analyzing large sample data is subsampling, by which one takes a random subsample from the original full sample and uses it as a surrogate for subsequent computation and estimation. In this paper, we study subsampling methods under two scenarios: approximating the full sample ordinary least-square (OLS) estimator and estimating the coefficients in linear regression. We present two algorithms, weighted estimation algorithm and unweighted estimation algorithm, and analyze asymptotic behaviors of their resulting subsample estimators under general conditions. For the weighted estimation algorithm, we propose a criterion for selecting the optimal sampling probability by making use of the asymptotic results. On the basis of the criterion, we provide two novel subsampling methods, the optimal subsampling and the predictor- length subsampling methods. The predictor-length subsampling method is based on the L2 norm of predictors rather than leverage scores. Its computational cost is scalable. For unweighted estimation algorithm, we show that its resulting subsample estimator is not consistent to the full sample OLS estimator. However, it has better performance than the weighted estimation algorithm for estimating the coefficients. Simulation studies and a real data example are used to demonstrate the effectiveness of our proposed subsampling methods. ",
        "keywords": [],
        "authors": [
            {
                "name": "rong zhu",
                "org": ""
            },
            {
                "name": "ping ma",
                "org": ""
            },
            {
                "name": "michael w mahoney",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "12r8oTjh": {
        "id": "12r8oTjh",
        "title": "Combined Features and Kernel Design for Noise Robust Phoneme Classification Using Support Vector Machines",
        "abstract": "This paper proposes methods for combining cepstral and acoustic waveform representations for a front-end of support vector machine (SVM)-based speech recognition systems that are robust to additive noise. The key issue of kernel design and noise adaptation for the acoustic waveform representation is addressed first. Cepstral and acoustic waveform representations are then compared on a phoneme classification task. Experiments show that the cepstral features achieve very good performance in low noise conditions, but suffer severe performance degradation already at moderate noise levels. Classification in the acoustic waveform domain, on the other hand, is less accurate in low noise but exhibits a more robust behavior in high noise conditions. A combination of the cepstral and acoustic waveform representations achieves better classification performance than either of the individual representations over the entire range of noise levels tested, down to - 18-dB SNR.",
        "keywords": [
            "acoustic signal processing",
            "cepstral analysis",
            "noise",
            "pattern classification",
            "speech recognition",
            "support vector machines",
            "acoustic waveform representation",
            "cepstral feature",
            "cepstral waveform representation",
            "kernel design",
            "noise adaptation",
            "noise robust phoneme classification",
            "speech recognition system",
            "support vector machine",
            "Acoustic waveforms",
            "kernels",
            "phoneme classification",
            "robustness",
            "support vector machines (SVMs)"
        ],
        "authors": [
            {
                "name": "Yousafzai, J.",
                "org": "Dept. of Inf., King''s Coll. London, London, UK|c|"
            },
            {
                "name": "Sollich, P.",
                "org": "king s college london"
            },
            {
                "name": "Cvetkovic, Z.",
                "org": "king s college london"
            },
            {
                "name": " Bin Yu",
                "org": "university of california berkeley"
            }
        ],
        "venue": "Audio, Speech, and Language Processing, IEEE Transactions",
        "year": 2010
    },
    "gOPfblsc": {
        "id": "gOPfblsc",
        "title": "Boosting with Early Stopping: Convergence and Consistency",
        "abstract": "Boosting is one of the most significant advances in machine learning for classification and regression. In its original and computationally flexible version, boosting seeks to minimize empirically a loss function in a greedy fashion. The resulting estimator takes an additive function form and is built iteratively by applying a base estimator (or learner) to updated samples depending on the previous iterations. An unusual regularization technique, early stopping, is employed based on CV or a test set. This paper studies numerical convergence, consistency and statistical rates of convergence of boosting with early stopping, when it is carried out over the linear span of a family of basis functions. For general loss functions, we prove the convergence of boosting's greedy optimization to the infinimum of the loss function over the linear span. Using the numerical convergence result, we find early-stopping strategies under which boosting is shown to be consistent based on i.i.d. samples, and we obtain bounds on the rates of convergence for boosting estimators. Simulation studies are also presented to illustrate the relevance of our theoretical results for providing insights to practical aspects of boosting. As a side product, these results also reveal the importance of restricting the greedy search step-sizes, as known in practice through the work of Friedman and others. Moreover, our results lead to rigorous proof that for a linearly separable problem, AdaBoost with epsilon -> 0 step-size becomes an L-1-margin maximizer when left to run to convergence.",
        "keywords": [
            "boosting",
            "greedy optimization",
            "matching pursuit",
            "early stopping",
            "consistency"
        ],
        "authors": [
            {
                "name": "Tong Zhang",
                "org": "IBM T. J. Watson Research Center|University of California at Berkeley"
            },
            {
                "name": "Bin Yu",
                "org": "IBM T. J. Watson Research Center|University of California at Berkeley"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2005
    },
    "jBY9uQfU": {
        "id": "jBY9uQfU",
        "title": "Cloud Detection over Snow and Ice Using MISR Data",
        "abstract": "Clouds play a major role in Earth's climate and cloud detection is a crucial step in the processing of satellite observations in support of radiation budget, numerical weather prediction and global climate model studies. To advance the observational capabilities of detecting clouds and retrieving their cloud-top altitudes, NASA launched the Multi-angle Imaging SpectroRa- diometer (MISR) in 1999, which provides data in nine difierent views of the same scene using four spectral channels. Cloud detection is particularly di-cult in the snow- and ice-covered po- lar regions and availability of the novel MISR angle-dependent radiances motivates the current study on cloud detection using statistical methods. Three schemes using MISR data for polar cloud detection are investigated in this study. Using domain knowledge, three physical features are developed for detecting clouds in daylight polar regions. The features measure the correlations between MISR angle-dependent radiances, the smoothness of the re∞ecting surfaces, and the amount of forward scattering of radiances. The three features are the basis of the the flrst scheme, called Enhanced Linear Correlation Matching Classiflcation (ELCMC). The ELCMC algorithm thresholds on three features and the thresholds are either flxed or found through the EM algorithm based on a mixture of two 1-dim Gaussians. The ELCMC algorithm results are subsequently used as training data in the development of two additional schemes, one Fisher's Quadratic Discriminate Analysis (ELCMC-QDA) and the other a Gaussian kernel Support Vector Machine (ELCMC-SVM). For both QDA- and SVM- based experiments two types of inputs are tested, the set of three physical features and the red radiances of the nine MISR cameras. All three schemes are applied to two polar regions where expert labels show that the MISR operational cloud detection algorithm does not work well, with a 53% misclassiflcation rate in one region and a 92% nonretrieval rate in the other region. The ELCMC algorithm produces misclassiflcation rates of 6.05% and 6.28% relative to ex- pert labelled regions across the two polar scenes. The misclassiflcation rates are reduced to approximately 4% by ELMCM-QDA and ELCMC-SVM in one region and approximately 2% in the other. Overall, all three schemes provided signiflcantly more accurate results and greater spatial coverage than the MISR operational stereo-based cloud detection algorithm. Compared with ELCMC-QDA, ELCMC-SVM is more robust against mislabels in the ELCMC results and provide slightly better results, but it is computationally slower.",
        "keywords": [
            "feature selection",
            "multi-angle imaging spectro- radiometer misr",
            "ice and snow",
            "quadratic discriminate analysis qda",
            "cloud detection",
            "thresholding.",
            "support vector machine svm",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Eugene E. Clothiaux",
                "org": "Department of Meteorology|Pennsylvania State University"
            },
            {
                "name": "Amy J. Braverman",
                "org": "Jet Propulsion Laboratory|California Institute of Technology"
            }
        ],
        "venue": "",
        "year": 0
    },
    "HissQoKs": {
        "id": "HissQoKs",
        "title": "A unified framework for high-dimensional analysis of $M$-estimators with decomposable regularizers",
        "abstract": "  High-dimensional statistical inference deals with models in which the the number of parameters p is comparable to or larger than the sample size n. Since it is usually impossible to obtain consistent procedures unless $p/n\\rightarrow0$, a line of recent work has studied models with various types of low-dimensional structure, including sparse vectors, sparse and structured matrices, low-rank matrices and combinations thereof. In such settings, a general approach to estimation is to solve a regularized optimization problem, which combines a loss function measuring how well the model fits the data with some regularization function that encourages the assumed structure. This paper provides a unified framework for establishing consistency and convergence rates for such regularized M-estimators under high-dimensional scaling. We state one main theorem and show how it can be used to re-derive some existing results, and also to obtain a number of new results on consistency and convergence rates, in both $\\ell_2$-error and related norms. Our analysis also identifies two key properties of loss and regularization functions, referred to as restricted strong convexity and decomposability, that ensure corresponding regularized M-estimators have fast convergence rates and which are optimal in many well-studied cases. ",
        "keywords": [
            "loss function",
            "information theory",
            "convergence rate",
            "sample size",
            "statistical inference",
            "convex programming"
        ],
        "authors": [
            {
                "name": "Sahand Negahban",
                "org": ""
            },
            {
                "name": "Pradeep D. Ravikumar",
                "org": ""
            },
            {
                "name": "Martin J. Wainwright",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "neural information processing systems",
        "year": 2009
    },
    "a6oT3E4o": {
        "id": "a6oT3E4o",
        "title": "Artificial Intelligence and Statistics.",
        "abstract": "Artificial intelligence (AI) is intrinsically data-driven. It calls for the application of statistical concepts through human-machine collaboration during the generation of data, the development of algorithms, and the evaluation of results. This paper discusses how such human-machine collaboration can be approached through the statistical concepts of population, question of interest, representativeness of training data, and scrutiny of results (PQRS). The PQRS workflow provides a conceptual framework for integrating statistical ideas with human input into AI products and researches. These ideas include experimental design principles of randomization and local control as well as the principle of stability to gain reproducibility and interpretability of algorithms and data results. We discuss the use of these principles in the contexts of self-driving cars, automated medical diagnoses, and examples from the authors’ collaborative research.",
        "keywords": [
            "Artificial intelligence",
            " Statistics",
            " Human-machine collaboration",
            " TP391",
            " C8"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of California"
            },
            {
                "name": "Karl Kumbier",
                "org": "University of California"
            }
        ],
        "venue": "Journal of Zhejiang University Science C",
        "year": 2018
    },
    "1EJMaNrb": {
        "id": "1EJMaNrb",
        "title": "Conifer species recognition: An exploratory analysis of in situ hyperspectral data",
        "abstract": "In situ hyperspectral data measured above sunlit and shaded sides of canopies using a high spectral resolution radiometer were analyzed for identification of six conifer tree species. An artificial neural network algorithm was assessed for the identification purpose. Linear discrimination analysis was compared with the neural network algorithm. The hyperspectral with the neural data were further processed to smoothed reflectance and first derivative spectra and were separately used in tree species identification. Tree species recognition with data collected front six study sites was tested in seven experiments. The average accuracy of species recognition was obtained at every site. The overall performance of the neural network algorithm was better than that of linear discriminant analysis for species recognition when the same number of training samples and test samples were used. The discriminant analysis produced better accuracy than neural network at one site where many samples (10) were taken from six individual trees. Use of the average spectra of all samples for a particular tree species in training may not result in higher accuracy than use of individual spectral samples in training. Use of sunlit samples alone resulted in an overall accuracy of greater than 91%. The effects of site background including illuminating conditions on tree species specra were large. Neural networks are sensitive to subtle spectral details and can be trained to separate samples front the same species at different sites. Our experiments indicate that the discriminating power of visible bands is stronger than that of near-infrared bands. Higher recognition accuracies can be obtained in the blue to green or the red-edge spectral region as compared with four other spectral regions. A smaller set of selected bands can generate more accurate identification than all spectral bands.",
        "keywords": [
            "near infrared",
            "data collection",
            "spectral resolution",
            "neural network",
            "artificial neural network",
            "discriminant analysis"
        ],
        "authors": [
            {
                "name": "Peng Gong",
                "org": "Center for Assessment and Monitoring of Forest and Environmental Resources, Department of Environmental Science, Policy and Management, University of California, Berkeley, USA"
            },
            {
                "name": "Ruiliang Pu",
                "org": "Center for Assessment and Monitoring of Forest and Environmental Resources, Department of Environmental Science, Policy and Management, University of California, Berkeley, USA"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, USA"
            }
        ],
        "venue": "Remote Sensing of Environment",
        "year": 1997
    },
    "npsARr1X": {
        "id": "npsARr1X",
        "title": "Co-clustering directed graphs to discover asymmetries and directional communities",
        "abstract": "In directed graphs, relationships are asymmetric and these asymmetries contain essential structural information about the graph. Directed relationships lead to a new type of clustering that is not feasible in undirected graphs. We propose a spectral co-clustering algorithm called di-sim for asymmetry discovery and directional clustering. A Stochastic co-Blockmodel is introduced to show favorable properties of di-sim. To account for the sparse and highly heterogeneous nature of directed networks, di-sim uses the regularized graph Laplacian and projects the rows of the eigenvector matrix onto the sphere. A nodewise asymmetry score and di-sim are used to analyze the clustering asymmetries in the networks of Enron emails, political blogs, and the Caenorhabditis elegans chemical connectome. In each example, a subset of nodes have clustering asymmetries; these nodes send edges to one cluster, but receive edges from another cluster. Such nodes yield insightful information (e.g., communication bottlenecks) about directed networks, but are missed if the analysis ignores edge direction.",
        "keywords": [
            "SVD",
            "Stochastic Blockmodel",
            "spectral clustering"
        ],
        "authors": [
            {
                "name": "Karl Rohe",
                "org": "Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706;"
            },
            {
                "name": "Tai Qin",
                "org": "Department of Statistics, University of Wisconsin-Madison, Madison, WI 53706;"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Statistics, University of California, Berkeley, CA 94720;;Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2016
    },
    "SLq78eWf": {
        "id": "SLq78eWf",
        "title": "Data spectroscopy: Eigenspaces of convolution operators and clustering",
        "abstract": "This paper focuses on obtaining clustering information about a distribution from its i.i.d. samples. We develop theoretical results to understand and use clustering information contained in the eigenvectors of data adjacency matrices based on a radial kernel function with a sufficiently fast tail decay. In particular, we provide population analyses to gain insights into which eigenvectors should be used and when the clustering information for the distribution can be recovered from the sample. We learn that a fixed number of top eigenvectors might at the same time contain redundant clustering information and miss relevant clustering information. We use this insight to design the data spectroscopic clustering (DaSpec) algorithm that utilizes properly selected eigenvectors to determine the number of clusters automatically and to group the data accordingly. Our findings extend the intuitions underlying existing spectral techniques such as spectral clustering and Kernel Principal Components Analysis, and provide new understanding into their usability and modes of failure. Simulation Studies and experiments on real-world data are conducted to show the potential of our algorithm. In particular, DaSpec is found to handle unbalanced groups and recover clusters of different shapes better than the competing methods.",
        "keywords": [
            "Gaussian kernel",
            "spectral clustering",
            "kernel principal component analysis",
            "support vector machines",
            "unsupervised learning"
        ],
        "authors": [
            {
                "name": "Tao Shi",
                "org": "Ohio State Univ, Dept Stat, Columbus, OH 43210 USA"
            },
            {
                "name": "Mikhail Belkin",
                "org": "Ohio State Univ, Dept Comp Sci & Engn, Columbus, OH 43210 USA"
            },
            {
                "name": "Bin Yu",
                "org": "Univ Calif Berkeley, Dept Stat, Berkeley, CA 94720 USA"
            }
        ],
        "venue": "ANNALS OF STATISTICS",
        "year": 2009
    },
    "XUbroCcQ": {
        "id": "XUbroCcQ",
        "title": "Evaluation of a MISR-Based High-Resolution Aerosol Retrieval Method Using AERONET DRAGON Campaign Data",
        "abstract": "Satellite-retrieved aerosol optical depth (AOD) can potentially provide an effective way to complement the spatial coverage limitation of a ground particulate air-pollution monitoring network such as the U.S. Environment Protection Agency's regulatory monitoring network. One of the current state-of-the-art AOD retrieval methods is the National Aeronautics and Space Administration's Multiangle Imaging SpectroRadiometer (MISR) operational algorithm, which has a spatial resolution of 17.6 km × 17.6 km. Although the MISR's aerosol products lead to exciting research opportunities to study particle composition at a regional scale, its spatial resolution is too coarse for analyzing urban areas, where the air pollution has stronger spatial variations and can severely impact public health and the environment. Accordingly, a novel AOD retrieval algorithm with a resolution of 4.4 km × 4.4 km has been recently developed, which is based on hierarchical Bayesian modeling and the Monte Carlo Markov chain (MCMC) inference method. In this paper, we carry out detailed quantitative and qualitative evaluations of the new algorithm, which is called the HB-MCMC algorithm, using recent AErosol RObotic NETwork (AERONET) Distributed Regional Aerosol Gridded Observation Networks (DRAGON) campaign data obtained in the summer of 2011. These data, which were not available in a previous study, contain spatially dense ground measurements of the AOD and other aerosol particle characteristics from the Baltimore-Washington, DC region. Our results show that the HB-MCMC algorithm has 16.2% more AOD retrieval coverage and improves the root-mean-square error by 38.3% compared with the MISR operational algorithm. Our detailed analyses with various metrics show that the improvement of our scheme is coming from the novel modeling and inference method. Furthermore, the map overlay of the retrieval results qualitatively confirms the findings of the quantitative analyses.",
        "keywords": [
            "aod retrieval methods",
            "atmospheric measuring apparatus",
            "baltimore-washington",
            "mcmc inference method",
            "monte carlo markov chain",
            "remote sensing",
            "regulatory monitoring network",
            "aod ground measurements",
            "misr aerosol products",
            "nasa misr operational algorithm",
            "district of columbia region",
            "root-mean-square error",
            "hierarchical bayesian modeling",
            "bayesian method",
            "bayes methods",
            "distributed regional aerosol gridded observation networks",
            "air pollution",
            "multiangle imaging spectroradiometer",
            "monte carlo methods",
            "aerosol robotic network",
            "air pollution public health impact",
            "hb-mcmc algorithm evaluation",
            "high-resolution aerosol retrieval",
            "aerosol optical depth",
            "aerosols",
            "aeronet dragon campaign data",
            "high-resolution aerosol retrieval method",
            "multiangle imaging spectroradiometer (misr)",
            "monte carlo markov chain (mcmc)",
            "national aeronautics and space administration misr",
            "radiometers",
            "air pollution environment impact",
            "united states environment protection agency",
            "ground particulate air-pollution monitoring network",
            "satellite-retrieved aod",
            "aerosol particle characteristics",
            "air quality",
            "particle composition",
            "markov processes",
            "vectors",
            "spatial resolution"
        ],
        "authors": [
            {
                "name": "Taesup Moon",
                "org": ""
            },
            {
                "name": "Yueqing Wang",
                "org": ""
            },
            {
                "name": "Yang Liu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2015
    },
    "JTYFFy7i": {
        "id": "JTYFFy7i",
        "title": "Hourglass multimedia content and service composition framework for smart room environments",
        "abstract": "Pervasive environments with their ubiquitous multimedia devices such as video-enabled cell-phones, laptops, PC tablets, digital cameras, HDTV plasma displays are becoming integral part of our workplaces and homes. Furthermore, these digital multimedia devices make it easier and easier to create and view volumes of content that can be stored throughout the Internet. The big challenge is to organize the distributed content, get the distributed multimedia content composed, produced and distributed to users in customized fashion according to users' preference, and their resource availabilities in pervasive environments. Basically, the challenge is to create Internet Interactive Television where the user/interest group, residing in a pervasive environment, corresponds to the TV program director who decides and/or influences what content(s) will be viewed, how it will be composed, presented and delivered. In this paper, we present a vision how this challenge can be solved. We propose a novel hourglass-based system that delivers composite multimedia content to users in pervasive environments, which considers both users' interest in the content and the presentation capabilities of various display devices. This hourglass-based system relies on our content and service composition framework that allows for customized production, distribution and presentation of multimedia content for pervasive environments. We present the hourglass design, possible solutions for some content composition scenarios and validate the solutions via selected experiments.",
        "keywords": [
            "ubiquitous multimedia device",
            "multimedia content",
            "customized fashion",
            "digital multimedia device",
            "smart room environment",
            "service composition framework",
            "internet interactive television",
            "composite multimedia content",
            "content composition scenario",
            "big challenge",
            "pervasive environment",
            "hourglass multimedia content",
            "customized production",
            "product distribution",
            "interactive television"
        ],
        "authors": [
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign, United States"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign, United States"
            },
            {
                "name": "Jin Liang",
                "org": "University of Illinois at Urbana-Champaign, United States"
            },
            {
                "name": "Yi Cui",
                "org": "University of Illinois at Urbana-Champaign, United States"
            }
        ],
        "venue": "Pervasive and Mobile Computing",
        "year": 2005
    },
    "kUC6HDO2": {
        "id": "kUC6HDO2",
        "title": "Collaborative dancing in tele-immersive environment",
        "abstract": "We present a study of collaborative dancing between remote dancers in a tele-immersive environment which features 3D full and real body capturing, wide field of view, multi-display 3D rendering, and attachment free participant. We invite two professional dancers to perform collaborative dancing in the environment. The coordination requires one dancer to take the lead while the other follows by appropriate movement. Throughout the experiment, the dancers are dancing at various motion rates to evaluate how well the collaborative dancing is supported with the current technical boundary. Our important findings indicate that 1) tele-immersive environments have strong potential impact on the concept of choreography and communication of live dance performance, 2) the presence of multi-view display, real body 3D rendering, audio channel, and less intrusiveness greatly enhances the immersive and dancing experience, and 3) the level of synchronization achieved by the dancers is higher than that expected from the video rate.",
        "keywords": [
            "audio channel",
            "multi-view display",
            "collaborative dancing",
            "important finding",
            "current technical boundary",
            "live dance performance",
            "appropriate movement",
            "tele-immersive environment",
            "real body",
            "attachment free participant",
            "collaboration",
            "field of view",
            "dance"
        ],
        "authors": [
            {
                "name": "Zhenyu Yang",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Wanmin Wu",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Ross Diankov",
                "org": "University of California at Berkeley"
            },
            {
                "name": "Ruzena Bajscy",
                "org": "University of California at Berkeley"
            }
        ],
        "venue": "ACM Multimedia 2001",
        "year": 2006
    },
    "KKxhWRRQ": {
        "id": "KKxhWRRQ",
        "title": "A Three-Layer Virtual Director Model for Supporting Automated Multi-Site Distributed Education",
        "abstract": "In multi-site distributed education (MSDE), video streams from multiple sites are available. To best utilize the limited screen space at each site, we develop a customizable, automated display man- agement system in this paper, i.e., only user-preferred streams will be shown as triggered by events and timers. The configuration of such user preference, however, is challenging because it has to be both human-friendly and machine-friendly. To address this chal- lenge, we propose a three-layer virtual director model. In the user layer, we identify three categories of parameters that can represent a wide range of user preferences yet are easy to use. These prefer- ences are then automatically translated into a machine-friendly timed automaton in the execution layer. The automaton is simu- lated dynamically, which selects a subset of streams to show on the screen through a display layer. Evaluation results demonstrate the correctness and efficiency of the proposed framework.",
        "keywords": [
            "automata",
            "displays",
            "switches",
            "language translation",
            "automatic control",
            "timed automaton"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Cha Zhang",
                "org": ""
            },
            {
                "name": "Yong Rui",
                "org": ""
            },
            {
                "name": "Klara Nahrstedt",
                "org": ""
            }
        ],
        "venue": "ICME",
        "year": 2006
    },
    "BK4kgp4I": {
        "id": "BK4kgp4I",
        "title": "Myview: customizable automatic visual space management for multi-stream environment",
        "abstract": "Recent years witnessed the emergence of more \"multi-stream\" Multimedia applications, such as multi-site distributed video conferencing, multi-perspective IPTV, and virtual touring of 3D digital worlds from multiple view points, etc.In this work, we study the problem of visual space management in such applications. The key observation is that there are multiple visual streams that need to be presented to the users, while the visual space is limited both by availability of physical display devices and by user's visual attention space. We argue that the visual space is a type of critical resource that requires careful management in similar way as other resources (such as CPU cycles and memory slots). Specifically, the unique challenges are how to model the visual streams and the viewers' preference among them, how to determine which of these visual streams should be presented to the viewer, and how the output windows of these selected streams should be arranged on the display devices.Many existing systems have explored the solution space from different perspectives, but none of them provide a solution that is customized to user interest, automatic to avoid unnecessary user input, and yields high visual quality screen output. In this work, we introduce a 3-phase visual space management framework called MyView that makes the following three key contributions. First, a generic shot-based visual stream model and a score-based viewer interest model are designed to represent user interest, which lays the foundation for automatic visual space management decisions. Second, an automatic stream selection algorithm is developed that maintains a timed automaton to calculate which visual streams should be selected for display. Third, a screen layout calculation algorithm is designed to compute the screen layout for presenting the selected visual stream(s) on one or multiple display devices in a visual pleasing way that maximizes screen space utilization.We have built a lecture recording and broadcasting system on top of the ConferenceXP platform to evaluate our solution. Results from both simulation experiments and user study have confirmed the functional correctness and usability of the MyView framework.",
        "keywords": [
            "selected visual stream",
            "customizable automatic visual space",
            "automatic visual space management",
            "multi-stream environment",
            "multiple visual stream",
            "yields high visual quality",
            "visual space",
            "visual space management",
            "visual attention space",
            "visual stream",
            "generic shot-based visual stream",
            "3-phase visual space management"
        ],
        "authors": [
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign"
            }
        ],
        "venue": "Myview: customizable automatic visual space management for multi-stream environment",
        "year": 2006
    },
    "Iesc1D8O": {
        "id": "Iesc1D8O",
        "title": "A multi-stream adaptation framework for bandwidth management in 3D tele-immersion",
        "abstract": "Tele-immersive environments will improve the state of collaboration among distributed participants. However, along with the promise a new set of challenges have emerged including the real-time acquisition, streaming and rendering of 3D scenes to convey a realistic sense of immersive spaces. Unlike 2D video conferencing, a 3D tele-immersive environment employs multiple 3D cameras to cover a much wider field of view, thus generating a very large volume of data that need to be carefully coordinated, organized, and synchronized for Internet transmission, rendering and display. This is a challenging task and a dynamic bandwidth management must be in place. To achieve this goal, we propose a multi-stream adaptation framework for bandwidth management in 3D tele-immersion. The adaptation framework relies on the hierarchy of mechanisms and services that exploits the semantic link of multiple 3D video streams in the tele-immersive environment. We implement a prototype of the framework that integrates semantic stream selection, content adaptation, and 3D data compression services with user preference. The experimental results have demonstrated that the framework shows a good quality of the resulting composite 3D rendered video in case of sufficient bandwidth, while it adapts individual 3D video streams in a coordinated and user-friendly fashion, and yields graceful quality degradation in case of low bandwidth availability.",
        "keywords": [
            "sufficient bandwidth",
            "dynamic bandwidth management",
            "bandwidth management",
            "tele-immersive environment",
            "content adaptation",
            "adaptation framework",
            "video stream",
            "low bandwidth availability",
            "video conferencing",
            "multi-stream adaptation framework",
            "real time",
            "data compression",
            "adaptation",
            "field of view",
            "col"
        ],
        "authors": [
            {
                "name": "Zhenyu Yang",
                "org": "University of Illinois at Urbana-Champaign, Goodwin, Urbana, IL"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign, Goodwin, Urbana, IL"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign, Goodwin, Urbana, IL"
            },
            {
                "name": "Ruzena Bajscy",
                "org": "University of California at Berkeley, Berkeley, CA"
            }
        ],
        "venue": "NOSSDAV",
        "year": 2006
    },
    "mFr0DNDl": {
        "id": "mFr0DNDl",
        "title": "Optimizing Visible Objects Embedding Towards Realtime Interactive Internet TV",
        "abstract": "Embedding new visible objects such as video or images into MPEG video has many applications in newscasting, pay- per-view, Interactive TV and other distributed video ap- plications. Because the embedded foreground content in- terferes with the original motion compensation process of the background stream, we need to decode macroblocks in I and P frames via motion compensation and re-encode all macroblocks with broken reference links via motion re- estimation. Although previous work has explored DCT- compressed domain algorithms and provided a heuristic ap- proach for motion re-estimation, the computation intensive motion compensation step is not much optimized and so still prevents efficient realtime embedding. In this work, we optimize previous work to enable realtime embedding processing that can be applied to Interactive Internet TV applications. We study the motion compensation process and show that on average up to 90% of the macroblocks decoded are not used at all. To explore this phenomenon, we propose to buffer a GOP (Group-Of-Picture) of frames and apply a backtracking process that identifies the minimum set of macroblocks which need to go through the decoding operation. At the price of a delay of one-GOP time, this ap- proach greatly speeds up the whole embedding process and enables on-line software embedding operation even capable for processing HDTV stream. Further optimizations are discussed and a real-world application scenario is presented. Experimental results have confirmed that this approach is much more efficient than previous solutions and results in equally good video quality.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Computer Science Department|University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "Computer Science Department|University of Illinois at Urbana-Champaign"
            }
        ],
        "venue": "",
        "year": 0
    },
    "sIvvwbmW": {
        "id": "sIvvwbmW",
        "title": "Internet-based interactive HDTV",
        "abstract": "Traditional interactive TV systems depend on expensive hardware, proprietary formats, and a closed-loop end-to-end approach, which greatly limits scalability and extensibility of TV services. In this paper, we present the HDControl interactive Internet TV architecture that achieves an open service model and combines high-quality video with flexible user control using two key software real-time algorithms: visual information embedding (VIE) algorithm and resynchronization algorithm. Experimental results in our HDTV testbed have confirmed the feasibility and efficiency of our proposed algorithms.",
        "keywords": [
            "Visual Information",
            "Service Model",
            "Open Service",
            "User Control",
            "Proprietary Format"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science University of Illinois at Urbana-Champaign 1401 West Green Street IL 61801 Urbana USA"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "Department of Computer Science University of Illinois at Urbana-Champaign 1401 West Green Street IL 61801 Urbana USA"
            }
        ],
        "venue": "Multimedia Syst.",
        "year": 2004
    },
    "KwMp4MKg": {
        "id": "KwMp4MKg",
        "title": "SpiderNet: an integrated peer-to-peer service composition framework",
        "abstract": "Service composition is highly desirable in peer-to-peer (P2P) systems where application services are naturally dispersed on distributed peers. However, it is challenging to provide high quality and failure resilient service composition in P2P systems due to the decentralization requirement and dynamic peer arrivals/departures. We present an integrated P2P service composition framework called SpiderNet to address the challenges. At service setup phase, SpiderNet performs a novel bounded composition probing protocol to provide scalable quality-aware and resource-efficient sendee composition in a fully distributed fashion. Moreover, SpiderNet supports directed acyclic graph composition topologies and explores exchangeable composition orders for enhanced service quality. During service runtime, SpiderNet provides proactive failure recovery to overcome dynamic changes (e.g., peer departures) in P2P systems. The proactive failure recovery scheme maintains a small number of dynamically selected backup compositions to achieve quick failure recovery for soft realtime streaming applications. We have implemented a prototype of SpiderNet and conducted extensive experiments using both large-scale simulations and wide-area network testbed. Experimental results show the feasibility and efficiency of the SpiderNet service composition solution for P2P systems.",
        "keywords": [
            "quality-aware",
            "p2p service composition framework",
            "spidernet service composition solution",
            "integrated peer-to-peer service composition",
            "integrated peer-to-peer service composition framework",
            "exchangeable composition order",
            "quality of service",
            "enhanced service quality",
            "large-scale simulation",
            "novel bounded composition",
            "wide-area network testbed",
            "system recovery",
            "acyclic graph composition topology",
            "soft realtime streaming application",
            "backup composition",
            "peer-to-peer system",
            "resource-efficient sendee composition",
            "p2p system",
            "failure resilient service composition",
            "wide area networks",
            "bounded composition probing protocol",
            "peer-to-peer computing",
            "application service",
            "spidernet framework",
            "distributed computing",
            "directed acyclic graph",
            "topology",
            "protocols",
            "service quality",
            "pervasive computing",
            "testing",
            "computer science",
            "p2p"
        ],
        "authors": [
            {
                "name": "Xiaohui Gu",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign"
            }
        ],
        "venue": "HPDC",
        "year": 2004
    },
    "Sbc9Eo3v": {
        "id": "Sbc9Eo3v",
        "title": "IPOD: Interactive Production On Demand",
        "abstract": "",
        "keywords": [
            "multimedia"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "klara nahrstedt",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "Fw8dd17P": {
        "id": "Fw8dd17P",
        "title": "Experience with Multi-Camera Tele-Immersive Environment",
        "abstract": "With their ability to extract, transfer and render 3D models of real world objects, multi-camera, tele-immersive environments are becoming promising next-generation of tele-communication systems. By rendering the 3D model of a remote object in an arbitrary way, determined by each individual viewer, tele-immersive environments offer great richness in tele-communication that is lacking in existing 2D based systems. ",
        "keywords": [],
        "authors": [
            {
                "name": "Jin Liang",
                "org": ""
            },
            {
                "name": "Zhenyu Yang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Yi Cui",
                "org": ""
            },
            {
                "name": "Klara Nahrstedt",
                "org": ""
            },
            {
                "name": "Sang-Hack Jung",
                "org": ""
            },
            {
                "name": "Arthur Yeap",
                "org": ""
            },
            {
                "name": "Ruzena Bajcsy",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "3T0Yhc80": {
        "id": "3T0Yhc80",
        "title": "A Study of Collaborative Dancing in Tele-immersive Environments",
        "abstract": "We first present the tele-immersive environments developed jointly by University of Illinois at Urbana-Champaign and University of California at Berkeley. The environment features 3D full and real body capturing, wide field of view, multi-display 3D rendering, and attachment free participant. We then describe a study of collaborative dancing between remotely located dancers in the shared virtual space. Two professional dancers are invited to the tele-immersive site of each university. As a preliminary experiment, we let the dancers perform elementary body movements and coordinate their dancing. The coordination requires one dancer to take the lead while the other follows her by appropriate movements. During the experiment, the dancers are dancing at various motion rates to evaluate how well the collaborative dancing is supported with the current technical boundary. Our important findings indicate that 1) tele-immersive environments have strong potential impact on the concept of choreography and communication of live dance performance, 2) the presence of multi-display system, real body 3D rendering, audio channel, and less intrusive-ness greatly enhances the immersive and dancing experience, and 3) the level of synchronization achieved by the dancers is higher than that expected from the video rate",
        "keywords": [
            "multidisplay system",
            "3d tele-immersive environments",
            "video signal processing",
            "collaboration",
            "tele-immersive environments",
            "preliminary experiment",
            "choreography",
            "audio channel",
            "elementary body movement",
            "shared virtual space",
            "collaborative dancing",
            "elementary body movements",
            "rendering (computer graphics)",
            "attachment free participant",
            "live dance performance communication",
            "multi-display system",
            "teleimmersive environment",
            "synchronization",
            "university of california",
            "dance",
            "real body 3d rendering",
            "appropriate movement",
            "humanities",
            "tele-immersive environment",
            "real body",
            "berkeley",
            "synchronisation",
            "tele-immersive site",
            "image motion analysis",
            "field of view"
        ],
        "authors": [
            {
                "name": "Zhenyu Yang",
                "org": "University of Illinois at Urbana-Champaign, USA"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign, USA"
            },
            {
                "name": "Wanmin Wu",
                "org": "University of Illinois at Urbana-Champaign, USA"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign, USA"
            },
            {
                "name": "Ross Diankov",
                "org": "University of California at Berkeley, USA"
            },
            {
                "name": "Ruzena Bajscy",
                "org": "University of California at Berkeley, USA"
            }
        ],
        "venue": "ISM",
        "year": 2006
    },
    "kIorqOgq": {
        "id": "kIorqOgq",
        "title": "A Framework for Future Internet-Based TV Broadcasting",
        "abstract": "IPTV, or Internet-Based TV broadcasting is going to significantly change the way people obtain information, get entertainment, and possibly collaborate with each other. Compared with today's TV system, IPTV gives the viewers more choice as to what to watch and how to watch, and allows users to broadcast their own programs easily, thus \"democratizing\" information broadcasting. To realize the vision of IPTV, however, there are many challenging issues, such as content-based channel discovery and selection, user view customization, and efficient media streaming. This position paper describes a framework for future IPTV systems where millions of viewers can select multiple channels, view them in a customized way, and cooperate with each other in a peer-to-peer fashion for TV program delivery.",
        "keywords": [
            "semantic aware adaptation",
            "display management",
            "content-based channel selection",
            "multi-channel view customization",
            "peer-to-peer streaming"
        ],
        "authors": [
            {
                "name": "Jin Liang",
                "org": "Department of Computer Science|University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science|University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Zhenyu Yang",
                "org": "Department of Computer Science|University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "Department of Computer Science|University of Illinois at Urbana-Champaign"
            }
        ],
        "venue": "World Wide Web Conference Series",
        "year": 0
    },
    "B12BOkns": {
        "id": "B12BOkns",
        "title": "TEEVE: The Next Generation Architecture for Tele-immersive Environment",
        "abstract": "Tele-immersive 3D multi-camera room environments are starting to emerge and with them new challenging research questions. One important question is how to organize the large amount of visual data, being captured, processed, transmitted and displayed, and their corresponding resources, over current COTS computing and networking infrastructures so that \"everybody\" would be able to install and use tele-immersive environments for conferencing and other activities. In this paper we propose a novel crosslayer control and streaming framework over general purpose delivery infrastructure, called TEEVE (Tele-immersive Environments for EVErybody). TEEVE aims for effective and adaptive coordination, synchronization, and soft QoSenabled delivery of tele-immersive visual streams to remote room(s). The TEEVE experiments between two teleimmersive rooms residing in different institutions more than 2000 miles apart show that we can sustain communication of up to 12 3D video streams with 4~5 3D frames per second for each stream, yielding 4~5 tele-immersive video rate.",
        "keywords": [
            "tele-immersive environments",
            "teeve experiment",
            "next generation architecture",
            "tele-immersive visual stream",
            "teleimmersive room",
            "soft qosenabled delivery",
            "multi-camera room environment",
            "general purpose delivery infrastructure",
            "tele-immersive environment",
            "remote room",
            "tele-immersive video rate",
            "quality of service",
            "teleconferencing",
            "frames per second"
        ],
        "authors": [
            {
                "name": "Zhenyu Yang",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Yi Cui",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Jin Liang",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Sang-hack Jung",
                "org": "University of California at Berkeley"
            },
            {
                "name": "Ruzena Bajscy",
                "org": "University of California at Berkeley"
            }
        ],
        "venue": "ISM",
        "year": 2005
    },
    "noHWn5hR": {
        "id": "noHWn5hR",
        "title": "Video summarization based on user log enhanced link analysis",
        "abstract": "Efficient video data management calls for intelligent video summarization tools that automatically generate concise video summaries for fast skimming and browsing. Traditional video summarization techniques are based on low-level feature analysis, which generally fails to capture the semantics of video content. Our vision is that users unintentionally embed their understanding of the video content in their interaction with computers. This valuable knowledge, which is difficult for computers to learn autonomously, can be utilized for video summarization process. In this paper, we present an intelligent video browsing and summarization system that utilizes previous viewers' browsing log to facilitate future viewers. Specifically, a novel ShotRank notion is proposed as a measure of the subjective interestingness and importance of each video shot. A ShotRank computation framework is constructed to seamlessly unify low-level video analysis and user browsing log mining. The resulting ShotRank is used to organize the presentation of video shots and generate video skims. Experimental results from user studies have strongly confirmed that ShotRank indeed represents the subjective notion of interestingness and importance of each video shot, and it significantly improves future viewers' browsing experience.",
        "keywords": [
            "intelligent video browsing",
            "link analysis",
            "video content",
            "unify low-level video analysis",
            "concise video summary",
            "video skim",
            "traditional video summarization technique",
            "intelligent video summarization tool",
            "video shot",
            "video summarization process",
            "efficient video data management",
            "feature analysis",
            "data management"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign, Urbana, IL"
            },
            {
                "name": "Wei-Ying Ma",
                "org": "Microsoft Research Asia, Haidian District, Beijing, P.R. China"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign, Urbana, IL"
            },
            {
                "name": "Hong-Jiang Zhang",
                "org": "Microsoft Research Asia, Haidian District, Beijing, P.R. China"
            }
        ],
        "venue": "ACM Multimedia 2001",
        "year": 2003
    },
    "41iSxvAv": {
        "id": "41iSxvAv",
        "title": "A compressed-domain visual information embedding algorithm for MPEG-2 HDTV streams",
        "abstract": "Many features of traditional TV service are becoming desirable for software multimedia applications to provide open solutions and improve flexibility. In this work, we have studied a new kind of service, what we call \"visual information embedding\", that comes from the idea of Picture-In-Picture. Based on previous work in MPEG-compressed domain algorithms, we propose a \"backtrack- ing\" approach that reduces the decoding complexity up to 90% and enables realtime processing on MPEG2 streams at the price of a delay of one Group-Of-Picture period. We have implemented a software realtime visual information embedding gateway for HDTV streams, and the experimental results have shown that our solution is practical and efficient.",
        "keywords": [
            "telecommunication standards",
            "open solutions",
            "compressed-domain visual information embedding algorithm",
            "tv service",
            "data compression",
            "mpeg-2 standard",
            "backtracking approach",
            "video coding",
            "software multimedia applications",
            "high definition television",
            "group-of-picture period delay",
            "software real-time gateway",
            "picture-in-picture",
            "code standards",
            "decoding complexity reduction",
            "mpeg-2 hdtv streams",
            "visual information embedding gateway",
            "real-time processing",
            "decoding",
            "transform coding",
            "computer science",
            "tv",
            "real time processing"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Department of Computer Science|University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "Department of Computer Science|University of Illinois at Urbana-Champaign"
            }
        ],
        "venue": "ICME (1)",
        "year": 2002
    },
    "w4jlGYmn": {
        "id": "w4jlGYmn",
        "title": "A realtime software solution for resynchronizing filtered MPEG2 Transport stream",
        "abstract": "With the increasing demand and popularity of multimedia streaming applications over the current Internet, manipulating MPEG streams in a real-time software manner is gaining more and more importance. In this work, we studied the synchronization problem that arises when a gateway changes the data content carried in an MPEG2 Transport stream. In short, the distance between original time stamps will be changed non-uniformly when the video frames are resized, and decoders will fail to reconstruct the encoding clock from the resulting stream. We propose a cheap software real-time approach to solve this problem, which basically reuses the original time stamp packets and adapts their distance to accommodate the changes in bit rate. Experimental results from a real-time HDTV stream filter shows that our approach is correct and efficient.",
        "keywords": [
            "real-time software",
            "original time stamp",
            "video signal processing",
            "time stamp packets",
            "cheap software",
            "resulting stream",
            "multimedia",
            "real-time software manner",
            "mpeg streams",
            "synchronization problem",
            "realtime software solution",
            "gateway",
            "original time stamp packet",
            "transport protocols",
            "mpeg2 transport stream",
            "internet",
            "real-time approach",
            "high definition television",
            "video streaming",
            "real-time hdtv stream filter",
            "multimedia communication",
            "real-time systems",
            "mpeg stream",
            "synchronisation",
            "real time software",
            "decoding",
            "real time",
            "application software",
            "real time systems",
            "encoding",
            "synchronization"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Klara Nahrstedt",
                "org": ""
            }
        ],
        "venue": "ISMSE",
        "year": 2002
    },
    "Cz6MZoHA": {
        "id": "Cz6MZoHA",
        "title": "A scalable overlay video mixing service model",
        "abstract": "",
        "keywords": [
            "scalable overlay video",
            "service model",
            "service",
            "algorithms",
            "video conferencing",
            "design",
            "overlay"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of Illinois at Urbana-Champaign, Urbana, IL"
            },
            {
                "name": "Klara Nahrstedt",
                "org": "University of Illinois at Urbana-Champaign, Urbana, IL"
            }
        ],
        "venue": "ACM Multimedia 2001",
        "year": 2003
    },
    "65rGx8DJ": {
        "id": "65rGx8DJ",
        "title": "Fundamentals of particle size analysis by fluctuating transmission autocorrelation with an extremely narrow beam",
        "abstract": "The theory of transmission fluctuation spectrometry (TFS) was recently developed for particle size analysis in dilute flow particle systems, whereby the statistical transmission fluctuations are used to extract the particle size distribution and particle concentration. In this paper, a new method of transmission fluctuation spectrometry with signal correlation is presented, whereby the beam diameter is assumed to be much less than the particle diameter. The transmission fluctuations are expressed in terms of the expectancy of the transmission product (ETP) and are obtained as a spectrum with respect to the variable correlation time. An analytical expression of the ETP through a monolayer is derived and the ETP of a 3-dimensional system is formulated based on the layer model.",
        "keywords": [
            "transmission fluctuation autocorrelation",
            "expectancy of the transmission product (etp)",
            "particle size analysis",
            "particle system",
            "3 dimensional",
            "spectrum",
            "particle size distribution"
        ],
        "authors": [
            {
                "name": "Jianqi Shen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": "College of Science, University of Shanghai for Science and Technology, Shanghai 200093, PR China"
            },
            {
                "name": "Yamin Xu",
                "org": "College of Science, University of Shanghai for Science and Technology, Shanghai 200093, PR China"
            },
            {
                "name": "Lei Liu",
                "org": "College of Science, University of Shanghai for Science and Technology, Shanghai 200093, PR China"
            },
            {
                "name": "Ulrich Riebel",
                "org": "Lehrstuhl Mechanische Verfahrenstechnik, Brandenburgische Technische Universität Cottbus, 03013 Cottbus, Germany"
            },
            {
                "name": "Xiaoai Guo",
                "org": "Lehrstuhl Mechanische Verfahrenstechnik, Brandenburgische Technische Universität Cottbus, 03013 Cottbus, Germany"
            }
        ],
        "venue": "Measurement",
        "year": 2008
    },
    "VKkOmxEv": {
        "id": "VKkOmxEv",
        "title": "Transmission fluctuation method for particle analysis in multiphase flow",
        "abstract": "The transmission fluctuations can be used for measurements on particle size and particle concentration in multiphase flows. In Gregory’s method, the beam diameter is required to be much larger than the particle diameter, which limits the application seriously. In this work, we introduce a new method of the transmission fluctuation measurement, in which the beam diameter can be less, equal to and larger than the particle diameter. The theoretical analysis proves that, when the beam-to-particle diameter ratio is within the range of 0.05 and 10, the new method is able to achieve satisfying measurement results. However, Gregory’s method is only suitable in the range of 5 and 10. Therefore, this new method enhances the transmission fluctuation measurements greatly.",
        "keywords": [
            "standard deviation",
            "extinction",
            "transmission fluctuations",
            "particle size analysis",
            "satisfiability",
            "particle size"
        ],
        "authors": [
            {
                "name": "Jianqi Shen",
                "org": ""
            },
            {
                "name": "Yamin Xu",
                "org": "College of Science, University of Shanghai for Science and Technology, Jungong Road 516, Shanghai 200093, China"
            },
            {
                "name": "Bin Yu",
                "org": "College of Science, University of Shanghai for Science and Technology, Jungong Road 516, Shanghai 200093, China"
            },
            {
                "name": "Huarui Wang",
                "org": "College of Science, University of Shanghai for Science and Technology, Jungong Road 516, Shanghai 200093, China"
            }
        ],
        "venue": "International Journal of Multiphase Flow",
        "year": 2008
    },
    "Apwjfhqj": {
        "id": "Apwjfhqj",
        "title": "Measurements on Particle Size Distribution and Concentration by Transmission Fluctuation Spectrometry with Temporal Correlation",
        "abstract": "",
        "keywords": [
            "empirical correction",
            "particle analysis",
            "particle concentration",
            "particle size distribution",
            "transmission fluctuation spectrometry with temporal correlation"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Jianqi Shen",
                "org": ""
            },
            {
                "name": "Yamin Xu",
                "org": ""
            },
            {
                "name": "Ulrich Riebel",
                "org": ""
            },
            {
                "name": "Xiaoai Guo",
                "org": ""
            }
        ],
        "venue": "Particle & Particle Systems Characterization",
        "year": 2008
    },
    "gQTHyFHw": {
        "id": "gQTHyFHw",
        "title": "Improved algorithm of light scattering by a coated sphere",
        "abstract": "An efficient numerical algorithm for computing the light scattering by a coated sphere is proposed. The calculation of relevant functions by different recurrence algorithms is discussed. The new algorithm avoids the numerical difficulties, which give rise to significant errors encountered in practice by prior methods. Exemplifying results such as extinction efficiency, scattering efficiency, light scattering intensity as well as calculation speed are provided. The results show that this algorithm is efficient, fast, numerically stable and accurate.",
        "keywords": [
            "Scattering",
            "Calculation",
            "Algorithm",
            "Coated sphere",
            "Mie coefficients"
        ],
        "authors": [
            {
                "name": "Lei Liu",
                "org": "School of Mathematics and Physics, Anhui University of Technology, Ma’anshan 243002, China"
            },
            {
                "name": "Huarui Wang",
                "org": "College of Physics and Electronic Engineering, Xuzhou Normal University, Xuzhou 221116, China"
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Science, University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Yamin Xu",
                "org": "Institute of Science, University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Jianqi Shen",
                "org": ""
            }
        ],
        "venue": "中国颗粒学报(英文版)",
        "year": 2007
    },
    "0AarOkkP": {
        "id": "0AarOkkP",
        "title": "Measurement on the mean particle size by transmission fluctuations",
        "abstract": "The transmission signal of a narrow beam irradiated on a flow particle system may fluctuate. The fluctuating transmission can be used to measure the particle size and particle concentration. Due to the simplicity in principle and in optical arrangement, this method may be applied to the real time, online measurement. In the method proposed by Gregory, the beam diameter is necessary to be small but it should be much larger than the particle size. In this work, a new model of data processing is presented, in which the beam diameter may be close to or even much smaller than the particle size. The numerical simulation and the experiments show that this model can attain more reasonable results.",
        "keywords": [
            "Particle sizing",
            "Transmission",
            "Transmission fluctuation"
        ],
        "authors": [
            {
                "name": "SHEN Jian-Qi",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "CAI Xiao-Shu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Bin Yu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "XU Ya-Min",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            }
        ],
        "venue": "Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics",
        "year": 2008
    },
    "apwSTgWm": {
        "id": "apwSTgWm",
        "title": "Signal processing in transmission fluctuation spectrometry with band-pass filter",
        "abstract": "Transmission fluctuation spectrometry is a recently-developed method for particle size analysis, in which both the particle size distribution and particle concentration can be obtained simultaneously. This work presents a new technique of data processing of the fluctuating transmission signal. The 1 st order band pass filter is employed to improve the resolution of the measurement. The analytical expression is obtained on the basis of the layer model. Numerical results and simulated results are given to make a comparison. © 2007 American Institute of Physics.",
        "keywords": [
            "particle analysis",
            "particle concentration",
            "particle size distribution",
            "transmission fluctuation",
            "data processing",
            "fluid dynamics",
            "signal processing",
            "band pass filter",
            "particle size analysis"
        ],
        "authors": [
            {
                "name": "Jianqi Shen",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Yamin Xu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Bin Yu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Xiaoai Guo",
                "org": "Technische Universität Cottbus(BTU Cottbus,Brandenburg University of Technology),Cottbus,Germany"
            },
            {
                "name": "Ulrich Riebel",
                "org": "Technische Universität Cottbus(BTU Cottbus,Brandenburg University of Technology),Cottbus,Germany"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2007
    },
    "n6lcTfPw": {
        "id": "n6lcTfPw",
        "title": "Effects of particle overlapping on transmission fluctuation spectrometry with temporal correlation",
        "abstract": "Transmission fluctuation spectrometry with temporal or spatial correlation is being developed as a new method for particle size analysis, in which the particle size distribution and particle concentration can be measured simultaneously. Based on the assumption of low particle concentrations, an analytical expression of the transmission fluctuation correlation spectrum can be obtained with a layer model. It is found that the measurement matches the theory very well as long as the particle concentration is low enough. However, as the particle concentration increases, the measured transmission fluctuation spectrum deviates gradually from the theory, which is a result of the high concentration effects. High concentration effects include particle overlapping and monolayer structure. In this work, theory and simulations on particle overlapping are studied. As a result, an empirical expression is found. © Taylor & Francis Group, LLC.",
        "keywords": [
            "particle analysis",
            "particle overlapping",
            "temporal correlation",
            "transmission",
            "transmission fluctuation spectrometry",
            "spatial correlation",
            "particle size distribution",
            "particle size analysis",
            "spectrum"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Jianqi Shen",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Yamin Xu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Huarui Wang",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Yuehuan Wei",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Haitao Yu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            }
        ],
        "venue": "Chemical Engineering Communications",
        "year": 2010
    },
    "PYMuTljo": {
        "id": "PYMuTljo",
        "title": "Measurements on particle by transmission fluctuation spectrometry using second order filter",
        "abstract": "The transmission fluctuation spectrometry (TFS), a new method can measure the particle size distribution (PSD) and particle concentration simultaneously in two-phase fluid system. With simple optical arrangement and easy operation, the method can be applied to real-time, online measurements. The transmission signal with fluctuations are analyzed by using a second order low pass filter (LPF), and the experimental data of transmission fluctuation spectra in the frequency domain are obtained. The particle size distributions and concentrations are extracted from the experimental data with the modified Chahine iterations. Effects on the spectra of transmission fluctuations of the high concentration are discussed. The high concentration correction includes frequency response to characteristic function and step height of the transition function. Parameters for the high concentration correction are achieved and further employed in the inversion algorithm, and reasonable measurement results are obtained. Analysis to the measurement data shows that, with the high-concentration correction, the particle size distribution and particle concentration can be recovered within a broad dynamic range and the largest measurable particle volume concentration depends on the particle size.",
        "keywords": [
            "High-concentration correction",
            "Inversion algorithm",
            "Optical metrology",
            "Particle sizing",
            "Transmission fluctuation spectrometry"
        ],
        "authors": [
            {
                "name": "Yamin Xu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Bin Yu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Lei Liu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Jianqi Shen",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            }
        ],
        "venue": "Guangxue Xuebao/Acta Optica Sinica",
        "year": 2006
    },
    "n3eVx03x": {
        "id": "n3eVx03x",
        "title": "Stability in Debye series calculation for light scattering by absorbing particles and bubbles",
        "abstract": "The Debye-series decomposition is of importance for understanding of light scattering features and for the validity of the geometrical optics approximation to light scattering. The numerical stability and accuracy for calculating light scattering with Debye series is studied and an improved algorithm is proposed in this work. The ratios of the Riccati–Bessel functions and the logarithmic derivatives of the Riccati–Bessel functions are employed and calculated with proper recurrences. Exemplifying results are provided to show the improvement of the algorithm.",
        "keywords": [
            "debye series calculation",
            "light scattering",
            "recurrence",
            "numerical stability",
            "bessel function",
            "geometric optics"
        ],
        "authors": [
            {
                "name": "Jianqi Shen",
                "org": ""
            },
            {
                "name": "Huarui Wang",
                "org": "University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Bingshan Wang",
                "org": "University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Haitao Yu",
                "org": "University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Bin Yu",
                "org": "University of Shanghai for Science and Technology, Shanghai 200093, China"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2010
    },
    "RZ6Dq8vd": {
        "id": "RZ6Dq8vd",
        "title": "New method for data processing of fluctuating transmission signals",
        "abstract": "The transmission signal of a narrow beam irradiated on two-phase flow may fluctuate. The fluctuating transmission signal can be used to measure particle size and particle concentration. Due to the simplicity in principle and in optical arrangement, this method may be applied to real time, online measurement. In this work, the disadvantage of the technique given by Gregory is discussed and a new data processing method is presented. Numerical simulation and actual measurements prove that both the ranges of particle size and particle concentration can be extended using the newly developed method.",
        "keywords": [
            "Correlation spectrometry",
            "Particle sizing",
            "Transmission",
            "Transmission fluctuation"
        ],
        "authors": [
            {
                "name": "Jianqi Shen",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Xiaoshu Cai",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Bin Yu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            },
            {
                "name": "Yamin Xu",
                "org": "University of Shanghai for Science and Technology(University of Shanghai for Science and Technology),Shanghai,China"
            }
        ],
        "venue": "Yi Qi Yi Biao Xue Bao/Chinese Journal of Scientific Instrument",
        "year": 2007
    },
    "0FIvz30V": {
        "id": "0FIvz30V",
        "title": "High concentration effects of transmission fluctuation spectrometry with temporal correlation",
        "abstract": "",
        "keywords": [
            "spectrum",
            "spatial correlation",
            "numerical simulation",
            "two phase flow",
            "real time",
            "particle size distribution"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Jianqi Shen",
                "org": ""
            },
            {
                "name": "Yamin Xu",
                "org": ""
            },
            {
                "name": "Huarui Wang",
                "org": ""
            }
        ],
        "venue": "Journal of Physics: Conference Series",
        "year": 2009
    },
    "HPcrvFsQ": {
        "id": "HPcrvFsQ",
        "title": "Particle analysis by transmission fluctuation spectrometry with temporal correlation in multiphase flow",
        "abstract": "The transmission signal of a narrow laser beam attenuated by particles in multiphase flow shows strong fluctuations, due to the presence and absence of particles in the beam path. The fluctuating transmission signal can be used for the measurement of both the particle size distribution (PSD) and particle concentration. In this paper, the theory of transmission fluctuation spectrometry with temporal correlation (TFSTC) is developed on the basis of the layer model and with the assumptions of geometric ray propagation and completely absorbent spherical particles. Experiments are realized in a focused Gaussian beam and the acquisition of transmission signals is achieved by using a high-resolution digital oscilloscope. Measurements on spherical and non-spherical particles over very wide ranges of particle concentrations are presented. The high concentration effects are discussed in detail and are used in the inversion algorithm to obtain reasonable results. As a result, the method of TFSTC is hopeful to be used for real-time, online applications.",
        "keywords": [
            "transmission fluctuation spectrometry",
            "temporal correlation",
            "particle size analysis",
            "high resolution",
            "real time",
            "particle size distribution"
        ],
        "authors": [
            {
                "name": "Jianqi Shen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": "College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Yamin Xu",
                "org": "College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China"
            },
            {
                "name": "Xiaoai Guo",
                "org": "College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China"
            }
        ],
        "venue": "Flow Measurement and Instrumentation",
        "year": 2007
    },
    "FMI1r5gB": {
        "id": "FMI1r5gB",
        "title": "Using SPIN to Validate CSCW System",
        "abstract": "Recently,CSCW system has shown a development tendency which has more users,more complex permission connection,larger configuration dimension,and more complicated cases to deal with.Consequently,the accessing control policy of CSCW system and the validation of it have become quite study-worthy topics in and out of China.Focusing on the design traits of CSCW system,has proposed one validation tactic of CSCW system.Researchers illustrate this validation tactic with examples,use RBAC model to depict the accessing control permission of CSCW system,and use the SPIN tool to apply model check to validate the attribute of CSCW system.",
        "keywords": [
            "temporary logic",
            "model checking",
            "CSCW",
            "SPIN",
            "RBAC"
        ],
        "authors": [
            {
                "name": "SHAN Zhuo-wei",
                "org": "Department of Computer Science,School of Information,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Computer Science and Engineering,Xidian University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2008
    },
    "aGqz2vSZ": {
        "id": "aGqz2vSZ",
        "title": "FORMAL MODELING AND VALIDATION OF SEMAPHORE BASED ON CCS",
        "abstract": "The method of formal modeling and validating the semaphore has been given by utilizing CCS(calculus of communicating systems).The semaphore is used to resolve communication issue between the processes.This method is also applied to the issues of resolving producer-consumer problem and dining problem of the philosophers with semaphore mechanism in modeling,logically illustration and validation.The method has certain universality and can be extended to other issues which also use semaphore mechanism to resolve the process communications.",
        "keywords": [
            "Semaphore CCS(calculus of communicating systems) Synchronization tree Formal model Process algebra"
        ],
        "authors": [
            {
                "name": "Qi Fangmin",
                "org": "Xining Centre Branch of People's Bank of China,Xining ,Qinghai,China"
            },
            {
                "name": "Yu Bin",
                "org": "Xi'an Dianzi University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Mou Like",
                "org": "Shaanxi Vocational and Technical College,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Dou Hongxi",
                "org": "Xining Centre Branch of People's Bank of China,Xining ,Qinghai,China"
            }
        ],
        "venue": "Computer Applications and Software",
        "year": 2011
    },
    "ZKb8mupr": {
        "id": "ZKb8mupr",
        "title": "A Modeling Method of Software Project Management Based on Petri Nets",
        "abstract": "A new Petri nets modeling method —Place expanding Petri nets is given .This tool has the dynamic modeling characteristics which are suitable to aid managing the project management process,and the software project management process as an example to introduce the features and advantages of Place expanding Petri nets in the management process modeling. Place expanding Petri nets can solve the question about how to build the management tools to the dynamic process which is difficult for traditional tools so as to achieve the optimal design purpose .This method is very common,for example,in software project management,and other aspects of modeling.",
        "keywords": [
            "software project management",
            "model",
            "Petri nets",
            "place expanding"
        ],
        "authors": [
            {
                "name": "QI Fang-min",
                "org": "Northwest University School of Information Science and Technology,Xi’an ,China"
            },
            {
                "name": "YU Bin",
                "org": "XiDian University School of Computer Science & Technology,Xi’an ,China"
            },
            {
                "name": "SHI Li-jun",
                "org": "Northwest University School of Information Science and Technology,Xi’an ,China"
            },
            {
                "name": "MOU Li-ke",
                "org": "Northwest University School of Information Science and Technology,Xi’an ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2007
    },
    "G3fR2FUX": {
        "id": "G3fR2FUX",
        "title": "Semantic Matching of Web Services Based on Choreographies",
        "abstract": "",
        "keywords": [
            "dfa",
            "integrating business processes",
            "semantic matching",
            "state transition",
            "finite state automaton",
            "labeling",
            "input output",
            "web service",
            "business process",
            "testing",
            "web services",
            "electronic commerce",
            "finite state machines",
            "automata"
        ],
        "authors": [
            {
                "name": "Lihui Lei",
                "org": ""
            },
            {
                "name": "Zhenhua Duan",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "CSCWD",
        "year": 2006
    },
    "dSIyUHbB": {
        "id": "dSIyUHbB",
        "title": "THE RESEARCH OF INTEGRATION M1DDLEWARE TECHNOLOGY BASED ON XML",
        "abstract": "In order to extend distributed computing environment and support scale system integration.Through analyzing the heterogeneous of distributed object on the network environment,this paper proposes an integrated middleware architecture based on XML,and implements middleware XSware based on this architecture.XSware adopts uniform protocol that can cross platform and uniform data interoperation stand- ard—XML.It can support component model,so user can select appropriate component technology to structrue distributed application system according to their needs.",
        "keywords": [
            "Heterogeneous",
            "Integration middleware",
            "SOAP",
            "XML"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Xidian University, Xi'an Shaanxi , China"
            },
            {
                "name": "Zheng Yafeng",
                "org": "Henan University of Finance and Economics,Zhengzhou Henan ,China"
            }
        ],
        "venue": "Computer Applications and Software",
        "year": 2006
    },
    "uO1D596n": {
        "id": "uO1D596n",
        "title": "A dynamic approach to detecting, eliminating and fixing memory leaks",
        "abstract": "This paper presents a dynamic approach to detecting, eliminating and fixing memory leaks. With our approach, a program to be analyzed is instrumented before its execution. Dynamic symbolic execution is employed so as to expose memory leaks occurring in all execution paths. During the program execution, information about each allocated memory area is updated when corresponding statements are executed. Based on this information, a back-end leak checker records the changes of variables pointing to each memory area, detects memory leaks and deallocates leaked memory areas. After the program execution, a fixed program containing deallocation statements is generated. We have implemented our approach in a tool called DEF_LEAK based on Low Level Virtual Machine compiler infrastructure. Experiments show that DEF_LEAK can detect more leaks than the existing dynamic detection tools for programs with user inputs. Moreover, DEF_LEAK is more effective for helping programmers understand and fix memory leaks than other detection tools. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",
        "keywords": [
            "Dynamic symbolic execution",
            "Leak detection",
            "Leak fixing",
            "Low level virtual machine",
            "Memory leaks"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Institute of Computing Theory and Technology and ISN Laboratory, Xidian University, Xi’an, 710071, China"
            },
            {
                "name": "Tian Cong",
                "org": "Institute of Computing Theory and Technology and ISN Laboratory, Xidian University, Xi’an, 710071, China"
            },
            {
                "name": "Zhang Nan",
                "org": "Institute of Computing Theory and Technology and ISN Laboratory, Xidian University, Xi’an, 710071, China"
            },
            {
                "name": "Duan Zhenhua",
                "org": "Institute of Computing Theory and Technology and ISN Laboratory, Xidian University, Xi’an, 710071, China"
            },
            {
                "name": "Du Hongwei",
                "org": "Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, 51855, China"
            }
        ],
        "venue": "Journal of Combinatorial Optimization",
        "year": 2019
    },
    "Ijm34Tce": {
        "id": "Ijm34Tce",
        "title": "Interactive Requirements Elicitation Methods to Support MDA and Assistant Tools",
        "abstract": "To support the development mode of MDA,this paper presents the tables-driven of interactive requirements elicitation methods and developes the supporting tools.This approach gets the customer demands by completing the participator table,the non-functional requirements table,use case cards,CRC cards and user feedback table,provides sufficient information for the establishment of calculation independent model CIM and the platform independent model PIM.",
        "keywords": [
            "Requirements elicitation",
            "Use case-driven",
            "MDA",
            "CIM",
            "PIM"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Xidian University,Xi'an ,China"
            },
            {
                "name": "ZHANG Chen",
                "org": "Xidian University,Xi'an ,China"
            },
            {
                "name": "HAO Ke-gang",
                "org": "Northwest University,Xi'an ,China"
            }
        ],
        "venue": "Computer Science",
        "year": 2008
    },
    "oRDabDqi": {
        "id": "oRDabDqi",
        "title": "Research on File Monitoring System Based on Hyperic HQ",
        "abstract": "This paper focuses on the internal leakage of sensitive information issues in SMEs,designs the file integration monitoring system,based on the system architecture and monitoring mechanism of Hyperic HQ,an opens source monitoring software.It uses file system filtering drive based kernel-level,intercepts I/O Request Packet(IRP) which I/O manager routes to the file system drive before it achieved the file system drive,executes user-defined routines,and through the application communicate with driver,implements control of file operations.This system implements file integration monitoring system on the LAN.It can avoid illegal operation on the file system and provide a better solution for LAN file system security.",
        "keywords": [
            "file system",
            "file filtering drive",
            "I/O Request Packet(IRP)",
            "Hyperic HQ software",
            "file integration",
            "kernel-level"
        ],
        "authors": [
            {
                "name": "GU Lin-ying",
                "org": "College of Computer Science and Technology,Xidian University,Xi’an ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Computer Science and Technology,Xidian University,Xi’an ,China"
            }
        ],
        "venue": "Computer Engineering",
        "year": 2011
    },
    "jbPsU0GZ": {
        "id": "jbPsU0GZ",
        "title": "Verifying temporal properties of programs: A parallel approach.",
        "abstract": "Abstract   Due to the nature in dealing only with observed executions of a real system, runtime verification is being pursued as a lightweight verification technique. However, the overhead for analyzing the desired temporal properties usually degrades performance greatly. The reasons are: (1) the low efficiency of the interpretive execution in the analyzing process, and (2) nondeterminism of the automata generated from temporal logic properties. To overcome them, this paper presents a parallel approach to verify full regular temporal properties of a program. With this approach, the program is written in Modeling, Simulation and Verification Language (MSVL), and the property is specified by a Propositional Projection Temporal Logic (PPTL) formula. Execution and verification of a program are carried out at the same time. Specifically, each trace generated from executing a program is divided into several segments which are verified in parallel. Also, in the process of verifying each segment, nondeterministic choices in the relative automaton of a temporal property are also handled in parallel. Finally, verification results of all the segments are merged to form the eventual result as well as the counterexample. Our parallel mechanism takes full advantage of the hardware resources and makes temporal property verification efficient in a multi-core system. Experiments show that our approach is practical in verifying temporal properties of large-scale programs in the real world.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": "ICTT and ISN Laboratory, Xidian University, Xi’an 710071, PR China"
            },
            {
                "name": "Zhenhua Duan",
                "org": "ICTT and ISN Laboratory, Xidian University, Xi’an 710071, PR China"
            },
            {
                "name": "Cong Tian",
                "org": "ICTT and ISN Laboratory, Xidian University, Xi’an 710071, PR China"
            },
            {
                "name": "Nan Zhang",
                "org": "ICTT and ISN Laboratory, Xidian University, Xi’an 710071, PR China"
            }
        ],
        "venue": "J. Parallel Distrib. Comput.",
        "year": 2018
    },
    "kcCLSE8s": {
        "id": "kcCLSE8s",
        "title": "WSDL MODELING AND IMPLEMENTATION BASED ON MDA",
        "abstract": "The modeling process of Web Services Description Language(WSDL)by the extensible Unified Modeling Language(UML)is described,and the conversion rules between UML model and the respective WSDL are introduced.",
        "keywords": [
            "MDA WSDL UML"
        ],
        "authors": [
            {
                "name": "Zhang Chen",
                "org": "Institute of Software Engineering,Northwest University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Yu Bin",
                "org": "Xidian University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Computer Applications and Software",
        "year": 2008
    },
    "LiZB6dos": {
        "id": "LiZB6dos",
        "title": "Semantic matching of web services for collaborative business processes",
        "abstract": "It is a prerequisite for automating business processes integration to dynamically discover usable web services. A formal approach to semantic matching of web services based on choreographies is presented to support it. First, an extended deterministic finite automaton (EDFA) is proposed by labeling state transitions with binary-tuples (input, output) rather than letters. EDFAs represent services more accurately: the nodes represent the states maintained by the service; the state transitions represent the communication activities of the service. Thus, the automata depicts the temporal sequences of communication activities that describe the behavior of services. Second, the semantics-based intersection of EDFAs is presented and the compatibility of services is evaluated by testing the emptiness of the languages accepted by EDFAs. Finally, component structures are introduced to describe services with two roles: invoking another service and/or being invoked by another service. The compatibility of services can be employed to discover usable services, moreover, to validate collaborative business processes.",
        "keywords": [
            "extended deterministic finite automaton",
            "communication activity",
            "usable service",
            "state transition",
            "web service",
            "semantics-based intersection",
            "formal approach",
            "collaborative business process",
            "component structure",
            "semantic matching",
            "usable web service",
            "deterministic finite automaton",
            "input output",
            "business process"
        ],
        "authors": [
            {
                "name": "Lihui Lei",
                "org": "Institute of Computing Theory & Technology, Xidian University, Xi'an, P.R. China"
            },
            {
                "name": "Zhunhua Duan",
                "org": "Institute of Computing Theory & Technology, Xidian University, Xi'an, P.R. China"
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Computing Theory & Technology, Xidian University, Xi'an, P.R. China"
            }
        ],
        "venue": "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
        "year": 2007
    },
    "lMrNRLSU": {
        "id": "lMrNRLSU",
        "title": "A HETEROGENEOUS DATA INTEGRATION METHOD BASED ON ONTOLOGY AND ITS IMPLEMENTATION",
        "abstract": "The difficulties of traditional integration approaches of heterogeneous data resource are analyzed,and an improved integration method based on ontology is presented.The goal of this method is to hold the semantic consistency of integration of heterogeneous data through describing the concept of domain by ontology and constructing semantic mapping relations.",
        "keywords": [
            "Ontology Heterogeneous data resource Mapping relations"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Xidian University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Zheng Yafeng",
                "org": "Henan University of Finance and Economics,Zhengzhou ,Henan,China"
            }
        ],
        "venue": "Computer Applications and Software",
        "year": 2007
    },
    "eXvX1XLt": {
        "id": "eXvX1XLt",
        "title": "Intelligent Video Surveillance System of Automatic Teller Machine Based on Hand Trajectory Recognition",
        "abstract": "In order to prevent the criminal behaviors for Automatic Teller Machine(ATM) timely,this paper designs an ATM intelligent video surveillance system based on hand trajectory recognition.A background model is built by Gaussian-mixture background modeling method with the video images collected in the monitored area,and the information of human body can be obtained by background subtraction method and tracking algorithm.By analyzing the area change of human body,it can judge whether there exist abnormal behaviors.If there is,it will give an alarm.Otherwise,it will detect the hand trajectory with the skin detection algorithm based on color space and some location constraints,then match and recognize the movement trajectory of hand by building an Hidden Markov Model(HMM) to determine whether there exist other abnormal behaviours further.Experimental results show that the recognition rate for the criminal behaviors of the method proposed can reach up to 88%.",
        "keywords": [
            "trajectory recognition",
            "Gaussian-mixture background modeling",
            "abnormal behavior",
            "YUV color space",
            "Hidden Markov Model(HMM)",
            "Automatic Teller Machine(ATM)"
        ],
        "authors": [
            {
                "name": "CHEN Qiong",
                "org": "School of Computer Science and Technology,Xidian University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Computer Science and Technology,Xidian University,Xi'an ,China"
            }
        ],
        "venue": "Computer Engineering",
        "year": 2012
    },
    "MmMlAbXs": {
        "id": "MmMlAbXs",
        "title": "Disambiguation Algorithm for Chinese Word Segmentation Based on Semantic Calculation",
        "abstract": "In this paper,based on a study of natural language understanding of Chinese characters algorithm to eliminate ambiguity.Aiming at cross ambiguity and combinational ambiguity,using the HowNet as the main semantic resources,using knowledge map's knowledge as representation,using the algorithms mentioned in this paper based on semantic calculations,and calculating the discrepancy field of semantic context,to select the correct sentence cut programs,so as to achieve the objective to remove ambiguities.Experiments show that the algorithm does indeed contribute to improving ambiguity cut to the correct rate.",
        "keywords": [
            "word sense disambiguation",
            "combinational ambiguity",
            "cross ambiguity",
            "natural language processing",
            "relevance"
        ],
        "authors": [
            {
                "name": "DENG Fan",
                "org": "College of Computer Science and Technology,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Computer,Xidian University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2008
    },
    "4TAAyTmX": {
        "id": "4TAAyTmX",
        "title": "Study on Matching of Web Services Based on Semantics",
        "abstract": "A method which used the description of the services based on OWL-S language and service searching is given.The method uses the pre-condition and post condition which the services must be met as a judge matching criteria,and this can speed up the matching of services and improve the matching accuracy,and prove the effectiveness of the method in the practical application.",
        "keywords": [
            "post-condition",
            "pre-condition",
            "Web ontology language for services",
            "Web services",
            "matching degree"
        ],
        "authors": [
            {
                "name": "WU Yun",
                "org": "Software Engineering Institute,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "Xidian University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2007
    },
    "qn3yG9IG": {
        "id": "qn3yG9IG",
        "title": "Utilizing fuzzy petri net for choreography based semantic web services discovery",
        "abstract": "Semantic Web Services have received great popularity these days for their capability of providing more automatic web services discoveries and compositions. However, the issue of behavior compatibility is still not properly solved. In this paper, we propose a choreography-based formal approach to discover semantic web services that are compatible with their behaviors. The fuzzy petri net is used to perform the modeling, verification, analysis and evaluation for the matchmaking of semantic web services. The requested and provided services are modeled by two fuzzy petri nets combined through a set of combination rules. By analyzing the composite fuzzy petri net, the behavior compatibility can be verified, and the matching degree between requested and provided services can be obtained. With our approach, the success rate and accuracy of the semantic web services discoveries can be improved, and the final services set can be optimized.",
        "keywords": [
            "behavior compatibility",
            "semantic web services",
            "composite fuzzy petri",
            "semantic web service",
            "final service",
            "semantic web services discovery",
            "automatic web services discovery",
            "fuzzy petri",
            "combination rule",
            "choreography-based formal approach",
            "ontology",
            "petri net"
        ],
        "authors": [
            {
                "name": "Peng Men",
                "org": "Institute of Computing Theory and Technology, Xidian University, Xi'an, P.R. China"
            },
            {
                "name": "Zhenhua Duan",
                "org": "Institute of Computing Theory and Technology, Xidian University, Xi'an, P.R. China"
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Computing Theory and Technology, Xidian University, Xi'an, P.R. China"
            }
        ],
        "venue": "ICATPN",
        "year": 2007
    },
    "VoZe8N3f": {
        "id": "VoZe8N3f",
        "title": "Analysis on the Characteristics and Mechanism of Debris Flow in Nabao Gully of Wangmo,Guizhou",
        "abstract": "A heavy rainfall was triggered in Wangmo County,Guizhou Province on June 5-6,2011.A debris flow was broken out in Nabao gully in this area,and caused plenty of damage.This study analyzed the source,topography and rainfall conditions of debris flow,and revealed that the large intensity of rainfalls and the large proportion of slopes in the range of 30°-40° were the triggering reason of shallow landslides,and the landslides provided the solid sources of debris flow.The characteristics and dynamic parameters of the debris flow are concluded as follows: the debris flow is one of the less viscous debris flow;the peak discharge is 25 m3/s,and the total volume of debris flow is about 6,100 m3.The debris flow in Nabao gully was induced by shallow landslide.In the light of the characteristics of Nabao gully,the local government and resident should attach great importance to these and take the corresponding biological and engineering measures to prevent debris flow.",
        "keywords": [
            "Nabao gully",
            "rainfall",
            "landslide",
            "debris flow",
            "gradient"
        ],
        "authors": [
            {
                "name": "WANG Tao",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "ZHU Yuan",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "CHEN Yuan-jing",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Geoscience",
        "year": 2013
    },
    "fi16RjBT": {
        "id": "fi16RjBT",
        "title": "INVESTIGATION OF SEVERE DEBRIS FLOW HAZARDS IN WENJIA GULLY OF SICHUAN PROVINCE AFTER THE WENCHUAN EARTHQUAKE",
        "abstract": "Many debris flow hazards were triggered recently in the epicenter area of the 2008 Wenchuan Earthquake.The severest debris flow is the debris flow in Wenjia Gully on Aug.13,2010.Wenjia Gully was a simply and ordinary gully and had no debris flow at all before the Wenchuan Earthquake.The formation conditions of debris flows were totally changed by a giant landslide caused by the earthquake.The giant landslide formed a landslide—debris deposition in the gully.The debris deposition had a volume of more than 30million cubic meters.The sediments were easily eroded by flash flood and formed debris flows.In the three raining seasons after the earthquake,a total of five large scale and giant scale debris flow were triggered.The largest and most harmful debris flow occurred on Aug.13,2010.The total rainfall during the debris flow was 227mm,and the duration of debris flow was 2.5 hours.The volume of debris flow was 3.1 million cubic meters.The debris flow resulted in 7 fatalities,5 persons listed as missing,39 persons injured,479 houses buried,and a direct economic loss of RMB 430 million.About 16%sediments of the landslide-debris deposition flew down out of the gully during the five large scale debris flows.New debris flows will be triggered by rainfall in the gully in the future.It will be a long-term effort for prevention and mitigation of the debris flow hazards in the gully.",
        "keywords": [
            "Debris flow",
            "Rainfall",
            "Landslide-debris",
            "Wenjia Gully",
            "Hazards Wenchuan Earthquake"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            },
            {
                "name": "MA Yu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            },
            {
                "name": "WU Yufu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            }
        ],
        "venue": "Journal of Engineering Geology",
        "year": 2010
    },
    "e0nfQWTc": {
        "id": "e0nfQWTc",
        "title": "ANALYSIS OF THE RISK AND PREVENTION METHOD ON THE SITE OF A HYDRAULIC POWER STATION IN TIBET,CHINA",
        "abstract": "There are 5 debris flows gullies in the area of a hydraulic power station in the Tibet.The debris flow occurred on July 22,2005 is the largest one in 100 years.The scale and hazards range of debris flows could affect the key equipments,constructing and running of power station.As there is plenty of solid material in the debris flow gullies and the slopes of debris flow channels are very large,debris flows will be triggered by enough rainfall.The hazards range calculated by the volume of debris flows is close to the real inundating range of debris flows in 2005,so the hazards ranges of debris flows of different frequency were calculated by the volume of debris flows of the same frequency.As the key equipments,constructing and running of power station could be harm by debris flows,the prevention works must be taken to keep the hazards of debris flows away from the hydraulic power station",
        "keywords": [
            "prevention works",
            "debris flow",
            "hazards range"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "National key laboratory of geohazards prevention and geoenvironment protection,Vhengdu University of technology,Chengdu ,China"
            },
            {
                "name": "YANG Yong-hong",
                "org": "National key laboratory of geohazards prevention and geoenvironment protection,Vhengdu University of technology,Chengdu ,China"
            },
            {
                "name": "TIE Yong-bo",
                "org": "National key laboratory of geohazards prevention and geoenvironment protection,Vhengdu University of technology,Chengdu ,China"
            },
            {
                "name": "LI Wei-le",
                "org": "National key laboratory of geohazards prevention and geoenvironment protection,Vhengdu University of technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Geological Hazards and Environment Preservation",
        "year": 2009
    },
    "MGtxKo0x": {
        "id": "MGtxKo0x",
        "title": "A Study of the Relationship between Frequency of Debris Flow and the Lithology in the Catchment of Debris Flow",
        "abstract": "It is qualitatively described the relationship between the hardness of rock in catchment and the triggering frequency of debris flow: the harder of rock in catchment,the lower frequency of debris flow is.But there is no quantitative relationship of the hardness and the triggering frequency.In this paper,17 catchments of debris flow in west Sichuan Province were investigated.The hardness of catchment,the triggering frequency of debris flow,and their relationship were researched.One can obtain the results from these research: ①The hardness of rock in the formation area is almost the same as the hardness of rock in the deposition area of debris flow catchment;②The hardness of catchment calculated by geology map is almost the same as the hardness of catchment obtained by investigated in field;③The relationship between the hardness of catchment and the triggering frequency of debris flow is: the(extremely) low frequency debris flows often happen in the hard rock area with the hardness ≥ 8,and the middle or high frequency debris flows often happen in the soft rock area with the hardness < 8.Finally,the comparing was made for the hardness of catchment and triggering frequency of 39 catchments of debris flow in other areas.It verified the boundary of(extremely) low frequency and middle or high frequency determined by hardness of 8 obtained in this study.",
        "keywords": [
            "Debris flow",
            "Lithology",
            "Hardness",
            "Frequency"
        ],
        "authors": [
            {
                "name": "Lu Ke",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China;Sichuan Institute of Geological Engineering Investigation,Chengdu ,China"
            },
            {
                "name": "Yu Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "Han Lin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China;No.9 Oil Extraction Factory of Daqing,Daqing ,China"
            },
            {
                "name": "Xie Hong",
                "org": "Institute of Mountain Hazards and Environment,CAS,Chengdu ,China"
            }
        ],
        "venue": "Advances in Earth Science",
        "year": 2011
    },
    "VNGqCjKV": {
        "id": "VNGqCjKV",
        "title": "Study on Earthquake Debris Flow in Dagan Gully,Dujiangyan,Sichuan",
        "abstract": "A catastrophic debris flow occurred in Dagan Gully,Hongkou,Dujiangyan,Sichuan Province on July 17,2009.The debris flow caused 2 persons disappearance,and plenty of farmland were covered by sediment.Landslides were triggered by heavy rainfall and blocked the channel.Strong flood made the dam-break and formed the debris flow.The Wenchuan Earthquake made the land lost part of stability.The debris flow in Dagan Gully on July 17,2009 is a typical earthquake debris flow.This kind of debris flow is more dangerous as it is difficult to be distinguished.It is likely triggered a large-scale debris flow by heavy rainfall in this gully in the future.The debris flow will block Baisha River and destroy the highway.",
        "keywords": [
            "block",
            "landslide",
            "debris flow",
            "dam-break",
            "Warthquake of Wenchuan"
        ],
        "authors": [
            {
                "name": "ZHANG Jiannan",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "MA Yu",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Huihui",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Mountain Science",
        "year": 2010
    },
    "VfnpmRbw": {
        "id": "VfnpmRbw",
        "title": "Characteristics of Critical Rainfall of Debris Flow after Earthquake——A Case Study of the Xiaogangjian Gully",
        "abstract": "The triggering thresholds such as cumulative antecedent rainfall and one hour rainfall intensity significantly decreased after earthquake events.The formation mechanism of debris flows in Xiaogangjian Gully of Qingping Township,Mianzhu County,Sichuan Province,China was obtained by field survey and analysis on the initiation of debris flows.The description of \"earthquake-landslide-deposits-rainfall-debris flows\"was the formation characteristic of debris flow in this gully.Base on the occurrence model of rainfall threshold of debris flow,the drop characteristics of rainfall threshold was obtained by comparing the thresholds of before and after the earthquake.The rainfall threshold of 2010 is only 21% of the rainfall threshold before earthquake,and it is only 23% in 2011.The threshold dropped noticeably right after earthquake events,and rose gradually thereafter.",
        "keywords": [
            "Xiaogangjian Gully",
            "initiation mechanism",
            "earthquake",
            "debris flow",
            "rainfall threshold"
        ],
        "authors": [
            {
                "name": "CHEN Yuanjing",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHU Yuan",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "WANG Tao",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Mountain Science",
        "year": 2013
    },
    "GVy1rLaC": {
        "id": "GVy1rLaC",
        "title": "The Group Debris Flow Hazards after the Wenchuan Earthquake in Longchi,Dujiangyan,Sichuan Province",
        "abstract": "Many group debris flow hazards were triggered by subsequent rainstorm in the Wenchuan Earthquake area after the main shock.Group debris flow hazards in Longchi,Dujiangyan,Sichuan Province is one of these disasters.There were 45 debris flows triggered by heavy rainfall in the catchment of Longxi River on August 13,2010.In the all 45 debris flows,there were 34 channelized debris flows and 11 debris flows on the slope.The total volume of debris flow was 3.34×106 m3 and plenty of sediment was deposited in the downstream of Longxi River.The rainfall which triggered the debris flows in Longxi River catchment on August 13,2010 was 75 mm in one hour.It was the same as one hour rainfall of twenty years return period.Most debris flows were distributing in 3 km from the triggering belt of Wenchuan Earthquake,only 11.1% of total debris flows were located in 3-5 km from the triggering belt.The distribution of debris flows were also controlled by the rock characteristics and geomorphology.Most of debris flows are viscous debris flows,only 11.1% of total debris flows were less viscous debris flows.There were 60.0% small scale debris flows and 11.1% large scale debris flows in total debris flows.Most catchments of debris flow were small catchment,68.9% of total catchments was less than 1 km2,only 6.7% of total catchments was larger than 3 km2.The sediment deposited in Longxi River was controlled by the activity of debris flows,the width of channel,and the slope of channel: there was no sediment deposited in the upper stream of Longxi River,but there was plenty of sediment deposited in the downstream.The size of sediment deposited in Longxi River was partly decided by the rock characteristics of debris flow catchments,as the results the particle sizes were decreasing from upper stream to downstream of Longxi River.The debris flow hazards will be triggered again when it is heavy rainfall in Longxi River catchment.To reduce the hazards of debris flows in the Wenchuan Earthquake area,forecast and prevention work must be done in the next raining season.",
        "keywords": [
            "Longxi River",
            "Longchi",
            "Wenchuan Earthquake",
            "group",
            "debris flow"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "Ma Yu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Jiannan",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "WU Yufu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Huihui",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "CHU Shengming",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Mountain Science",
        "year": 2011
    },
    "qIUKKMaD": {
        "id": "qIUKKMaD",
        "title": "Study on Mean Velocity of Thin Viscous Debris Flows",
        "abstract": "Thin viscous debris flows are common and dangerous,and their mean velocities are the most important one of their dynamic parameters.It is very important to be able to simply and accurately calculate the mean velocity of thin viscous debris flows.There are still some problems in application of the empirical formulas currently available for the mean velocity of thin viscous debris flows.Based on analysis of the relation of the volume concentration vesus velocity and resistance of the thin viscous debris flows from a series of field observation data,an empirical formula has been proposed to calculate the mean velocity of the thin viscous debris flows.The empirical formula is applicable to various types of flow gullies,and general rapid thin viscous debris flows;but not slow ones because the calculated velocities are larger than the observed ones.The formula is simple and stable in practical calculation,and its results are very close to those obtained with other methods.It is also applicable to the thin viscous debris flow upstream the piled fan;but the calculated velocity of the piled fan is larger than the real one;the further down stream the piled fan is the location,the larger the velocity difference is.",
        "keywords": [
            "hydraulic radius",
            "mean velocity",
            "thin viscous debris flows"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Disaster Prevention and Mitigation Engineering",
        "year": 2009
    },
    "CxZbJ61p": {
        "id": "CxZbJ61p",
        "title": "Formation Mechanism of the \"20110606\" Debris Flows within Wangmo,Guizhou",
        "abstract": "The \"20110606\" rainstorm(105.9 mm/h)triggered many debris flows in Wangmo County,Guizhou Province.During the hazards,thirty-seven people were killed and fifteen people were lost,and many houses were seriously destroyed.In order to improve the result accuracy of the forecasting and early warning system,based on field investigation and analysis,this paper analysis formation and mechanism of debris flows.The results reveal the following aspects:(1)the tense outbreak of debris flow is an inevitable coupling result of topography,material sources and rainstorms,and the rainfall breaking the 50-year record is the main factor for the outbreak of those debris flows,but the steep terrain and soft rock layers,such as sandstones and shales etc.,are the important causes;(2) the formation mechanism of debris flows,including bed-failure-triggered debris flow,outburst-triggered debris flow and landslide-triggered debris flow were main types in this area,and the initiation of bed-failure-triggered debris flow was surface flow→erosion gradually→transformed into debris flow,and the initiation of outburst-triggered debris flow was collapse→block→burst→transformed into debris flow,the initiation of landslide-triggered debris flow was rainwater infiltration→failure→fluidization→transformed into debris flow.",
        "keywords": [
            "formation mechanism",
            "Wangmo",
            "Guizhou",
            "debris flow"
        ],
        "authors": [
            {
                "name": "MA Yu",
                "org": "The Engineering and Technical College,Chengdu University of Technology,Leshan,Sichuan ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "WANG Tao",
                "org": "State Key Laboratory of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Geoscience",
        "year": 2012
    },
    "fII5B5zr": {
        "id": "fII5B5zr",
        "title": "Research on the Calculating Density by the Deposit of Debris Flows",
        "abstract": "The density of debris flows is the most important parameter of debris flows.It is more important to get the density of debris flows with the need of the evaluation and prevention the hazards of debris flows.In this paper,the size of coarse particle,fine particle and clay of debris flows,i.e.2mm,0.05mm and 0.005mm,and their percentage were analyzed for the relationship with the density of debris flows.The percentages of coarse particle,fine particle and clay of debris flows have certain relationships with density of debris flows,but they are not the unique because the difference of region.The percentage of clay in viscous debris flows is the same with the percentage of clay in the solid source of debris flows,but the percentage of clay in less viscous debris flows is much more than the percentage of clay in the solid source of debris flows.Comparing the living samples and deposit samples of debris flows with the calculating density of debris flows by the percentages of coarse particle and fine particle,it is good consistency.But the calculating density of debris flows must obey the density range obtained by the characteristics of deposit of debris flows.",
        "keywords": [
            "particle size",
            "density",
            "percentage",
            "deposit",
            "debris flows"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention,Chengdu University of Technology,Chengdu "
            }
        ],
        "venue": "Acta Sedimentologica Sinica",
        "year": 2008
    },
    "3Pag2pyd": {
        "id": "3Pag2pyd",
        "title": "Risk Analysis Based on the Evolution of Earthquake Dammed Debris Flow——A Case from the Evolution of Barrier Lake in Chayuan Gully,Wenchuan",
        "abstract": "Chayuan gully in Wenchuan of Sichuan Province is a low frequency debris flow gully.The debris flow return period is 50 years.Three barrier lakes were formed in Wenchuan Earthquake by the downstream of the basin of Chayuan Gully.The dams were partly damaged and the lakes disappeared during the rainy season in 2009.There were lots landslides,rock falls and barrier lakes after Earthquake.The trigger flood of debris flow changes to 5 years return period,more serious scale and risk than before.With the barrier lakes disappeared and less water,but plenty of landslides and rock falls in the basin.the trigger flood of debris flow occurs 5 years return period.The scale and risk of Debris Flow are less after earthquake,but larger than those before earthquake.The trend of risk of Chayuan gully debris flow is concluded from the evolution analysis of the barriers lakes,and the comparison of other barrier lakes in debris flow gully in Wenchuan Earthquake area.",
        "keywords": [
            "risk",
            "earthquake",
            "Wenchuan",
            "debris flow",
            "barrier lake"
        ],
        "authors": [
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Jian-nan",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "MA Yu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Hui-hui",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Guilin University of Technology",
        "year": 2011
    },
    "Mw4dj7w8": {
        "id": "Mw4dj7w8",
        "title": "RESEARCH ON THE GIANT DEBRIS FLOW HAZARDS IN ZHOUQU COUNTY,GANSU PROVINCE ON AUGUST 7,2010",
        "abstract": "The reason of giant debris flow triggering was obtained by field investigation and analysis on the debris flow formation conditions:heavy rainfall happened in the upstream of Sanyanyu Gully and Luojiayu Gully.The recorded rainfall was 77.3mm in one hour from 23 to 24 o'clock,August 7,2010.The heavy rain caused powerful flash flood in the catchments,which destroyed several natural dams and prevention dams in the two gullies.Then the giant debris flows were formed.The debris flows were high density viscous debris flows.The total volume of debris flows and the volume of sediment in debris flows were estimated at 144.2 × 104m3 and 97.7 × 104m3,respectively.The large boulder involving in debris flows moved with powerful impact force and destroyed more than 5500 houses in depositional fans.The debris flows produced a dam with 550m in length,70m in width,and 10m in height in Bailongjiang River.The dam blocked the river and formed a lake with 3km in length and half of Zhouqu city was inundated.As of August 18,2010,the debris flows claimed 1287 death,with further 457 listed as missing.The tendency of debris flow development was obtained by a preliminary analysis of the initiation conditions of debris flows:(1) The debris flows will be triggered if there is a heavy rainfall in the upstream of debris flows gullies recently,but the scale of debris flows will be less than the scale of debris flows on August 7,2010;(2) The debris flows will be triggered if there is a heavy rainfall in the upstream of debris flows gullies in a few years,the scale of debris flows will be a little bit less than the scale of debris flows on August 7,2010;(3) The scale of debris flows 20 years later will be the same as the scale of debris flows before Wenchuan Earthquake if there is no more earthquake effect this area and a event of large scale debris flow has happened in these gullies.",
        "keywords": [
            "Dam",
            "Debris flow",
            "Zhouqu",
            "Rainfall",
            "Earthquake"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            },
            {
                "name": "YANG Yonghong",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            },
            {
                "name": "SU Yongchao",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            },
            {
                "name": "HUANG Wenjie",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            },
            {
                "name": "WANG Gaofeng",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu "
            }
        ],
        "venue": "Journal of Engineering Geology",
        "year": 2010
    },
    "lwTclrWe": {
        "id": "lwTclrWe",
        "title": "Topographical factor-based shallow landslide hazard assessment: a case of Dayi area of Guizhou Province in China",
        "abstract": "Three groups of factors related to topography, geology and hydrology have influence on the triggering of shallow landslides in soil material. In this paper a single representative factor (T-factor) for the topography is proposed, which can be used to define threshold values for the possibility of shallow soil slides. This study was carried out in the Dayi area, Guizhou Province, China. During a heavy rainfall event on June 6, 2011, 230 shallow soilslides were triggered. In some slopes, no shallow landslides were triggered even though some of the topographical factors point to unstable high probability.",
        "keywords": [
            "Topographical threshold factor",
            " Rainfall threshold factor",
            " Shallow landsliding",
            " Dayi catchment"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu, China"
            },
            {
                "name": "Yunbo Zhu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu, China"
            },
            {
                "name": "Yang Liu",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection, Chengdu University of Technology, Chengdu, China"
            }
        ],
        "venue": "Geoenvironmental Disasters",
        "year": 2017
    },
    "5AB0gMBu": {
        "id": "5AB0gMBu",
        "title": "Characteristics of \"6·6\" Debris Flow Disaster in Wangmo County of Guizhou Province and Prevention Suggestions",
        "abstract": "A group of debris flows were triggered by heavy rainfall in Wangmo County,Guizhou Province in the early morning,June 6,2011.The debris flows were distributed mainly in upstream catchments of Dajian River,Dayi River,and Lewang River in the north of Wangmo County.The group of debris flows was the largest occurrence since 1949,which caused numerous losses of lives and property damages.These debris flows were featured by low frequency,less viscosity debris flow,strongly erosion in the channels and large intensity of rainfall.The deposition on the fans and burial of houses were the major hazardous aftermath of these debris flows.It is very likely that these kinds of debris flows could be triggered again under the same heavy rainfall in the future.Preventive suggestions including evacuation and engineering projects were proposed to mitigate this kind of hazards.",
        "keywords": [
            "group debris flow",
            "prevention suggestion",
            "low frequency"
        ],
        "authors": [
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geo-hazards Prevention and Geo-environment Protection, Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geo-hazards Prevention and Geo-environment Protection, Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "MA Yu",
                "org": "The Engineering and Technical College,Chengdu University of Technology,Leshan,Sichuan ,China"
            },
            {
                "name": "WANG Tao",
                "org": "State Key Laboratory of Geo-hazards Prevention and Geo-environment Protection, Chengdu University of Technology,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Bulletin of Soil and Water Conservation",
        "year": 2013
    },
    "oZbedJsZ": {
        "id": "oZbedJsZ",
        "title": "RELATIONSHIP OF FREQUENCY OF DEBRIS FLOWS AND THE PARTICLE SIZE IN THE CHANNEL",
        "abstract": "Debris flow is one of geological disasters in Mountains.Significant damages and losses were often caused by low frequency debris flow.In western region of Sichuan Province 17 debris flow gullies were investigated and particle sizes were measured in the catchments of debris flows.The relationship between coarse particles size and the frequency of debris flows was studied.From the analysis of the characteristics of rock,the coarse particle size and the frequency of debris flows,the conclusions were obtained:(1) the coarse particle size in the formation area is almost the same as the coarse particle size in the deposition area of debris flow catchment.So the coarse particle size in the formation area can be replaced by the coarse particle size in the deposition area;(2) The mean size of coarse particle in middle and high frequency debris flow gullies is less or equal to 20 cm,and the mean size of coarse particle in low and extremely low frequency debris flow gullies is more or equal to 25 cm;(3) The harder rock,the larger coarse particle size is,and the lower frequency of debris flow is;(4) The frequency of debris flow was primarily determined by the characteristics of rock and the size of coarse particles.It is easily and useful to predict the frequency of debris flow by use the characteristics of rock and the coarse particle size in the low frequency debris flow gully:referring to the geological map,judgment the main characteristics of rock,assignment the size of coarse particle,choosing the effected factors,frequency of debris flow could be determined.These works could help to understand and predict the low frequency debris flows.",
        "keywords": [
            "particle size",
            "frequency",
            "debris flow"
        ],
        "authors": [
            {
                "name": "HAN Lin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China;Planning and Design Institute of No.9 Oil Extraction Factory of Daqing,Heilongjiang Province,Daqing ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "LU Ke",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China;Sichuan Institute of Geological Engineering Investigation,Chengdu ,China"
            }
        ],
        "venue": "Resources and Environment in the Yangtze Basin",
        "year": 2011
    },
    "547aGxSP": {
        "id": "547aGxSP",
        "title": "DEBRIS FLOW GENESIS ITS EFFECT ON A HYDROPOWER STATION FACTORY",
        "abstract": "Debris flow is one of the geologic hazard which can often seen in hydropower station construction,and analyzing the cause formation and hazard assessment of debris flow is important for station construction.Based on the field investigation data in the station area,the paper analysed the cause of formation and assessment the hazard of five debris flow gullies which threaten the station factory,and the evolution trend of debris flow and its effect in different engineering stages.The results can provide reasonable suggestions for decision making during the design,construction and working of station construction.",
        "keywords": [
            "impaction analysis",
            "cause formation",
            "hazard assessment",
            "debris flow",
            "evolution trend"
        ],
        "authors": [
            {
                "name": "TIE Yong-bo",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "TANG Chuan",
                "org": "State Key Laboratory of Geological Hazard and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geological Hazard and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Geological Hazards and Environment Preservation",
        "year": 2010
    },
    "RqHdc3Bf": {
        "id": "RqHdc3Bf",
        "title": "A Study of Hazard Assessment of Debris Flows in Longchi Area of Dujiangyan City,Sichuan Province",
        "abstract": "Debris flows of Wenchuan earthquake-stricken area are more active than before earthquake.It is the primary work for the disaster prevention and mitigation of reconstruction process to assess debris flow hazard.Based on the study of scales of debris flows,areas of debris flow alluvial fans and the corresponding disaster loss,we used the average deposition thickness on alluvial fan instead of the debris flow scale,as a major factor for hazard assessment of single debris flow.The method was used to assess the hazards of 29 channelized debris flows of Longxi river basin on August 13,2010.The results indicated that 9 debris flows were high hazard,12 debris flows were moderate hazard and 8 debris flows were low hazard.Another method using debris flow scale as a major hazard factor was applied to assess the debris flow hazards in Longchi area.Some 65.5% of the evaluation results were unanimous in the two assessment methods.The method using average deposition thickness on alluvial fan as major hazard factor can strengthen the contribution of the scale to comprehensive hazard degree,and can more truly reflect the hazard level of debris flow with small drainage area and small alluvial fan at small-middle scale.",
        "keywords": [
            "Debris flow",
            "Average deposition thickness",
            "Longchi",
            "Hazard assessment"
        ],
        "authors": [
            {
                "name": "Liu Qinghua",
                "org": "State Key Laboratory of GeoHazard Prevention and GeoEnvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "Yu Bin",
                "org": "State Key Laboratory of GeoHazard Prevention and GeoEnvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "Tang Chuan",
                "org": "State Key Laboratory of GeoHazard Prevention and GeoEnvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "Li Li",
                "org": "State Key Laboratory of GeoHazard Prevention and GeoEnvironment Protection, Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Advances in Earth Science",
        "year": 2012
    },
    "10Lnmaa5": {
        "id": "10Lnmaa5",
        "title": "Preliminary study on the effect of debris flows from Goose Foot River on Lake Qionghai, Sichuan, China",
        "abstract": "Aggradations are very important for the developing and dying-out of lakes. The aggradations of floods and debris flows are common environmental problems in fault lakes in southwestern China. Investigating the background of the basin of Goose Foot River, the effect of human activities on Lake Qionghai, Sichuan Province, China, and the underwater topography maps of 1988 and 2003 were analyzed. In the past 30 years, turbidity currents were formed by debris flows and floods of Goose Foot River and took huge sediment into Lake Qionghai. The sediment not only pushed the coastline of Lake Qionghai at Goose Foot River fan into lake, but also deposited in the lake to the opposite bank. Debris flows took much more sediment into Lake Qionghai than the soil erosion did in the same basin. There is an underwater levee on the underwater fan. The underwater levee is 2 km in length, 200 m ( at south coast) to 600 m (at north coast) in width and the average 2 m in height. The maximum height of sediment deposition at underwater levee is 8. 29 m, or 0. 55 m for every year. There is a channel on the slope of the underwater fan of Goose Foot River mouth eroded by turbidity currents. The main source of sediment is the sediment token by the debris flows in 1996, 1997 and 1998. It should be paid more attention on the environment issues,such as basic characteristics, underwater topography of Lake Qionghai and the effect of Goose Foot River debris flows on Lake Qionghai.",
        "keywords": [
            "Debris flow",
            "Lake Qionghai",
            "sediment",
            "underwater levee"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Mountain Disaster and Environment, Chinese Academy of Sciences, , Chengdu , P. R. China"
            },
            {
                "name": "WANG Shige",
                "org": "Institute of Mountain Disaster and Environment, Chinese Academy of Sciences, , Chengdu , P. R. China"
            },
            {
                "name": "ZHANG Shucheng",
                "org": "Institute of Mountain Disaster and Environment, Chinese Academy of Sciences, , Chengdu , P. R. China"
            },
            {
                "name": "MENG Guocai",
                "org": "Institute of Mountain Disaster and Environment, Chinese Academy of Sciences, , Chengdu , P. R. China"
            }
        ],
        "venue": "Journal of Lake Sciences",
        "year": 2006
    },
    "ngd7olnZ": {
        "id": "ngd7olnZ",
        "title": "Experiment on the Initiation of Debris Flow by Flood",
        "abstract": "There were large landslides and rock falls in the debris flow gully in the earthquake area during Wenchuan Earthquake. The initiation condition of debris flow was changed greatly. To find out the critical velocity of flood for initiating debris flow,experiments of critical hydraulic conditions for initiating particles and debris flows were conducted in the laboratory. The conclusions are that the critical condition of initiation of debris flow is between the conditions of initiation of a little particle and abundance particle. The probability of critical initiation is 0. 05,two times as much as the probability of initiation of a little particle,one third of initiation probability of abundance particle. The critical velocity of initiation of particle and debris flow increases with the median particle size and asymmetrical coefficient of sediment. It decreases with the bed slope. The revised equation of initiating velocity of particle and debris flow can be used in the calculation of initiating velocity of coarse particle and large asymmetrical coefficient of sediment.",
        "keywords": [
            "asymmetrical coefficient",
            "critical velocity",
            "initiation",
            "debris flow",
            "median particle size"
        ],
        "authors": [
            {
                "name": "ZHANG Hui-hui",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "ZHANG Jian-nan",
                "org": ""
            }
        ],
        "venue": "Journal of Guilin University of Technology",
        "year": 2013
    },
    "xf2FlCf9": {
        "id": "xf2FlCf9",
        "title": "Forming Mechanism and Characteristics of Debris Flow Happened on August 13,2010 in Jianping Gully",
        "abstract": "After the bed was activated,the solid material on both sides of Jianping Gully was driven,forming a large-scale debris flow in Longchi Township of Dujiangyan City in Sichuan on August 13,2010,under the action of heavy rain.The debris flow washed away farm tourism facilities,Longchi highway and drinking water supply facilities at the mouth of gully.This is a typical gully-type debris in the earthquake-stricken region.Through analysis on the forming mechanism and dynamic parameters of volume weight,velocity,discharge and volume of the debris flow,it obtains dangerous ranges and threaten objects.It analyzes and predicts the possibility of happening again under the action of precipitation,according to the conditions of loose mass accumulation in the gully.It also puts forward suggestions on prevention and control based on conditions of accumulation at the mouth of gully.",
        "keywords": [
            "forming mechanism",
            "Jianping Gully",
            "characteristic",
            "debris flow",
            "earthquake-stricken region"
        ],
        "authors": [
            {
                "name": "CHU Sheng-ming",
                "org": "State Key Laboratory of Geo-Hazard Prevention and Geo-Environment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geo-Hazard Prevention and Geo-Environment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geo-Hazard Prevention and Geo-Environment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Soil and Water Conservation in China",
        "year": 2011
    },
    "OHX1X6G2": {
        "id": "OHX1X6G2",
        "title": "Research on the Disaster of Debris Flow of Bayi Gully,Longchi,Dujiangyan,Sichuan on August 13,2010",
        "abstract": "Based on field investigation and analysis,the formation conditions of the debris flow occurred in Bayi Gully,LongChi,Dujiangyan,like topography,water source and sediment source,were analyzed.The characteristics and formation of debris flow were elaborated and dynamic parameters were calculated,which were the density of 1.88 g·cm-3,discharge of 1 082 m3·s-1,and yield stress of debris flows more than 6 700 Pa.The total volume of sediment in debris flows were estimated at 116×104 m3,the large boulder involving in debris flows in depositional fans have powerful impact force.Finally,the development trend of the debris flow was predicted.Because there are a lot of collapse and landslide in the drainage basins,so it have maximum possibility of happening large-scale debris flow in continuous heavy rainfall.",
        "keywords": [
            "Characteristics",
            "Debris flow",
            "Earthquake",
            "Formation",
            "Prediction"
        ],
        "authors": [
            {
                "name": "MA Yu",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu Univ.of Technol.,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu Univ.of Technol.,Chengdu ,China"
            },
            {
                "name": "WU Yu-fu",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu Univ.of Technol.,Chengdu ,China"
            },
            {
                "name": "ZHANG Jian-nan",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu Univ.of Technol.,Chengdu ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu Univ.of Technol.,Chengdu ,China"
            }
        ],
        "venue": "Journal of Sichuan University(Engineering Science Edition)",
        "year": 2011
    },
    "2MGxsKus": {
        "id": "2MGxsKus",
        "title": "Debris flow of Shuangyangzi gully,Dujiangyan City in Wenchuan earthquake area",
        "abstract": "In 2010,the intense rainstorm on 13 August induced debris flow hazard in Dujiangyan City,Sichuan Province,the affecting area of Wenchuan earthquake.This debris flow is the result of both rainfall and earthquake.Therefore,it is significant to make clear of the development characteristics of debris flows by studying its formation and movement process in high seismic intensity area.For discussing the starting way of debris,this paper analyzed the watershed,especially the gully channel characteristics of Shuangyangzi gully based on field survey after the Wenchuan earthquake.Earthquake induced acitive development of disasters as collapse,landslide and provided abundant incompact solid matters,in addition,there are several drop water dams and rockfill dams in the gully.After the H1 landslide on the right bank of Shuangyangzi gully slided and blocked gully channel in case of heavy rainfall under the inducement of the flood,debris flow outburst.It can be concluded that the debris flow could outburst again in the next heavy rainfall.",
        "keywords": [
            "Shuangyangzi gully",
            "storm",
            "debris flow",
            "dam-break"
        ],
        "authors": [
            {
                "name": "Wu Yufu",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,,Chengdu,China"
            },
            {
                "name": "Yu Bin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,,Chengdu,China"
            },
            {
                "name": "Ma Yu",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,,Chengdu,China"
            },
            {
                "name": "Zhang Huihui",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,,Chengdu,China"
            },
            {
                "name": "Chu Shengming",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,,Chengdu,China"
            },
            {
                "name": "Li Li",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,,Chengdu,China"
            }
        ],
        "venue": "Science of Soil and Water Conservation",
        "year": 2011
    },
    "iQqFucSW": {
        "id": "iQqFucSW",
        "title": "Study on the Mean Velocity of Viscous Debris Flows",
        "abstract": "Viscous debris flows is the most regular and dangerous debris flows.The velocity of debris flow is the most important parameter in the dynamics parameter of debris flow.It is very important to calculate the velocity of viscous debris flow exactly and easily.The resistance of debris flow is quite different at different area: high resistance of debris flow area with low velocity;low resistance of debris flow area with high velocity.All equations of velocity of viscous debris flow at present are not good at all kinds of resistance area.The asymmetric coefficients of debris flows are quite different in different area: large asymmetric coefficients of debris flow with low resistance;small asymmetric coefficients of debris flow with high resistance.The asymmetric coefficients of debris flow could be used to classify resistance characteristics of debris flow accurately and the resistance law of viscous debris flows was got by asymmetric coefficients.By a series field observation data,an empirical equation of mean velocity of viscous debris flow was got.The velocity calculated by the asymmetric coefficients,bottom slope and hydraulic radius of flow.It is good at both high resistance and low resistance area of debris flows.It is good consistent for the measuring velocity of otherwise field observation data of debris flow and viscous mudflow by this empirical equation.The Froude number of flow is the factor of flow status: supercritical flow or subcritical flow.Ordinary viscous debris flows are supercritical flows,minorities are subcritical flows,and few are slow-motion debris flows which have too large density.The empirical equation is excellent at ordinary supercritical viscous debris flow,but it is bad for the slow-motion flow with large density of debris flow,and it is gentle large for the subcritical viscous debris flow.In the evaluation and prevention of debris flows,the mean velocity equation could be used for the velocity calculated of viscous debris flow in the channel at the upstream of the debris flow fans.At the same time,it is gentle large for the calculating the velocity of viscous debris flow on the debris flow fans.It is bad for the slow-motion debris flow,but the slow-motion could be ignored in the evaluation and prevention of debris flows.",
        "keywords": [
            "Asymmetric coefficient.",
            "Viscous",
            "Mean velocity",
            "Debris flows"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Advances in Earth Science",
        "year": 2008
    },
    "z1StUVLu": {
        "id": "z1StUVLu",
        "title": "Study on the disaster of earthquake debris flows of Xiaogou gully,Hongkou,Dujiangyan in Wenchuan earthquake area,Sichuan,China",
        "abstract": "A number of earthquake debris flows were caused by the Wenchuan earthquake.This paper discusses the characteristics and happening conditions of the typical sequential debris flows in the earthquake area.Through field observation of the Xiaogou gully basin located in Hongkou,Dujiangyan,Sichuan Province and laboratory experimental data analysis,it reaches the conclusion that first,many landslides were triggered by the Wenchuan earthquake on May 12,2008 and many potential landslides lost their balance in the earthquake but were not triggered in the Xiaogou gully basin.Second,the landslides were mainly triggered by heavy rainfalls.The channel was blocked by landslides and formed some dams and lakes.Heavy rainfall and floods broke these dams,formed strong floods,eroded the bed of the channel,and therefore formed debris flows.Right now,there are still many potential landslides in the Xiaogou gully basin.They are easily triggered by heavy rainfalls block the channel with the effect of flood,and finally form debris flows.Because of their potentiality and concealment,these debris flows in the Xiaogou gully are much more dangerous.",
        "keywords": [
            "Earthquake debris flow",
            "Landslide",
            "Wenchuan earthquake"
        ],
        "authors": [
            {
                "name": "ZHANG Hui-hui",
                "org": " State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "MA Yu",
                "org": " State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Jian-nan",
                "org": " State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": " State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": " State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Chengdu University of Technology(Science & Technology Edition)",
        "year": 2011
    },
    "C8F1VBE6": {
        "id": "C8F1VBE6",
        "title": "Research On Rainfall and The Prediction of Debris Flow",
        "abstract": "",
        "keywords": [
            "bandpass filter",
            "wind speed",
            "time series",
            "climate change",
            "spatial pattern",
            "general circulation model"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "VVwn6G3q": {
        "id": "VVwn6G3q",
        "title": "Features and Formation Mechanism of Debris Flow in Dabaiyang Gully in Upper Reaches of Minjiang River",
        "abstract": "The Dabaiyang gully is located at the Jiaochang epsilon-type structure in the north of Diexi town,Maoxian County,Sichuan Province,which is in upper reaches of Minjiang River.Two large-scale flow debris events occurred in the gully in 1935 and 1991,and the flow debris in 1935 was caused by the 1933 Diexi Earthquake(Ms=7.5) which is huge with peak flow of 557 m3/s.After the analysis of the landform,available loose materials and water conditions of two tributaries(Dagou and Xiaogou gullies) in Dabaiyang gully,it was obtained that there are sufficient conditions for the formation of tributary debris flow,which explains the intense activity of debris flow in the Xiaogou gully:(1)the average longitudinal gradient is 275‰ in the Dagou gully and 398‰ in the Xiaogou gully,and the relative altitude is 2,023 m;(2)the total amount of loose materials is 292,100 m3 in the Dagou gully and 420,100 m3 in the Xiaogou gully,and the source of materials is abundant.The formation mechanism of debris flow was also analyzed.It reveals that the formation of debris flow caused by the fire hose effect in the Dagou gully,and by the fire hose effect and the burst of barrage body in the Xiaogou gully.The flux of historical debris flow was calculated by mud trace investigation method,and the flux of future debris flow was appropriately forecasted,which provides valuable data for preventing debris flow disaster in Dabaiyang gully.",
        "keywords": [
            "Dabaiyang gully",
            "formation mechanism",
            "upper reaches of Minjiang River",
            "earthquake",
            "feature",
            "debris flow"
        ],
        "authors": [
            {
                "name": "WU Yu-fu",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "CHU Sheng-ming",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            },
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Geoscience",
        "year": 2012
    },
    "WVHPwzAy": {
        "id": "WVHPwzAy",
        "title": "Possibility of Blocking River and Prevention Countermeasures for Kushuigou Debris Flow",
        "abstract": "In August 13,2010,Kushui gully occurred large-scale debris flow,blocked the main river,caused dam break and disaster.This article studies the causes of debris flow of available loose materials,landform,water conditions and basic characteristics.According to the sample and flood tracking section in gully,it calculates the static and kinetic parameters,such as the density of debris flow,yield stress,velocity and flow.And then,the possibility of blocking river by Kushuigou debris flow is analyzed.Finally,some prevention countermeasures are put forward.",
        "keywords": [
            "Kushui gully",
            "cause",
            "blocking river",
            "debris flow"
        ],
        "authors": [
            {
                "name": "QI Xing",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "WU Yufu",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "CHU Shengming",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection, Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geohazards Prevention and Geoenvironment Protection, Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Water Resources and Power",
        "year": 2013
    },
    "SL25IGaA": {
        "id": "SL25IGaA",
        "title": "Debris Flow Characteristics of Chunyashu Gully and Prevention Countermeasures",
        "abstract": "Aiming at the large scale debris flow caused by strong rainfall,this paper investigates the conditions and characteristics of debris flow occurrence by taking the Longchi Town of Dujiangyan City in Sichuan Province for an example.Based on the site investigation and experimental data of Chunyashu debris flow,it is obtained that the gully,matter sources and water sources are the key factors for control of debris flow,which provides suggestions for calamity reduction and prevention.",
        "keywords": [
            "Chunyashu gully",
            "earthquake",
            "landslide",
            "debris flow"
        ],
        "authors": [
            {
                "name": "ZHANG Huihui",
                "org": "State Key Laboratory of Geological Hazards Prevention and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geological Hazards Prevention and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "WU Yufu",
                "org": "State Key Laboratory of Geological Hazards Prevention and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": "State Key Laboratory of Geological Hazards Prevention and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Jiannan",
                "org": "State Key Laboratory of Geological Hazards Prevention and Geological Environment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Water Resources and Power",
        "year": 2011
    },
    "32rWyja1": {
        "id": "32rWyja1",
        "title": "Study on the Method for Deposition Depth Calculation of Debris Flow with Different Densities",
        "abstract": "The deposit depth of debris flow is one of the most important parameters in the evaluation and prevention of debris flow.So far,there is no better method for deposit depth calculation of debris flow with different densities.In this paper the characteristics of yield stress of debris flow was studied and a method was proposed for the yield stress calculation using area parameters and volume concentration of debris flow.Base on the analysis of yield stress of debris flow,the deposit depth of debris flow can be obtained.This method can be used for the calculation of deposit depth of debris flows with different densities in debris flow areas.This work provides a better tool for the evaluation and prevention of debris flows.",
        "keywords": [
            "yield stress",
            "deposit depth",
            "debris flow",
            "different density"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention and Geoenvironment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Disaster Prevention and Mitigation Engineering",
        "year": 2010
    },
    "RAzx1wpa": {
        "id": "RAzx1wpa",
        "title": "Activity tendency of debris flow gully in Wenchuan County after \"5.12\" Wenchuan earthquake",
        "abstract": "A strong Wenchuan earthquake happened on May 12,2008. Many debris flows were triggered in earthquake stricken area by Wenchuan earthquake. In this paper, we focus attention on the debris flows in Wenchuan County, Sichuan Province. The debris flow gullies in different earthquake intensity areas and with different characteristics were investigated. The activity tendency of debris flows was obtained by analyzing the solid source features of debris flows, such as the volume and location of sediment provided by landslides and avalanche. The time of earthquake effect on triggering debris flow was discussed. These works will provide some references to the prevention and mitigation of debris flow hazard in earthquake stricken areas.",
        "keywords": [
            "Activity tendency",
            "Debris flow gully",
            "Wenchuan great earthquake"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Chengdu University of Technology(Chengdu University of Technology),Chengdu,China"
            },
            {
                "name": "Hong Xie",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "WANG Shi-ge",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "ZHANG Shu-cheng",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Ke Lu",
                "org": "Chengdu University of Technology(Chengdu University of Technology),Chengdu,China"
            },
            {
                "name": "Lin Han",
                "org": "Chengdu University of Technology(Chengdu University of Technology),Chengdu,China"
            }
        ],
        "venue": "Journal of Natural Disasters",
        "year": 2011
    },
    "4MnCKuGe": {
        "id": "4MnCKuGe",
        "title": "Research on the Improved Calculating Density of Less Viscosity Debris Flows",
        "abstract": "The particle distribution of the deposition of less viscosity debris flow is not the real particle distribution as the sorting of less viscosity of debris flow. The deposition of transitional debris flow is close to its real particle distribution as the transitional debris flow is weak sorting. Comparing the particle distributions of depositions of less viscosity and transitional debris flows with their real particle distributions,we get the fine particle is the main part of less viscosity debris flow,and the percentage of >5 mm is small. Most percentages of coarse particles in less viscosity debris flows are aggrandized. To correct the aggrandized percentage of coarse particle in less viscosity debris flow,delete the coarse part of >5 mm is necessary. The real densities of less viscosity debris flows are good consistency with the densities calculated by the corrected particle distributions and improved equation. To correct the aggrandized percentage of coarse particle in transitional debris flow,delete the coarse part of >20 mm is necessary. The real densities of transitional debris flows are better consistency with the densities calculated by the corrected particle distributions.",
        "keywords": [
            "particle distribution",
            "improved",
            "density",
            "percentage",
            "less viscosity debris flows"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key Laboratory of Geohazard Prevention,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Mountain Science",
        "year": 2009
    },
    "Xk7k0qAa": {
        "id": "Xk7k0qAa",
        "title": "The \"6·06 \"Disaster Characteristics and Forming Mechanism of Debris Flow in Wangmo,Guizhou",
        "abstract": "On June 6,2011,most of the northern areas of Wangmo county in Guizhou province had the biggest rainfall in a century and led to breaking out a large scale group debris flows.The disaster caused serious harm to local residents and traffic.The flow disaster characteristics of Dahao gully are particularly outstanding.Some tributaries were developed in Dahao gully.Its gully bed slope is relatively moderate,but steep slope and larger catchment area for the formation of the debris flow select hydrodynamic conditions.The Dahao gully is located in classic rock development area and has thicker loose deposits.Because the bank slope of Dahao gully is more steep,there are 19 shallow landslides in it according to field investigation.In addition,The landscape is be strongly destroyed by villagers.Terraces were fortified along the ditch for special source of material to the out breaking of debris flow.We can found that the formation mechanism is not consistent by the study of its four tributaries.2# tributary has more gentle slope and more shallow landslides,so its forming type is the shallow landslide-debris flow.But the rest of three tributaries have more steep slope and they are the gully-shape debris flow.Because less shallow landslides was formed in them,their most of material from the ditch bed.Surveying the slope gradient on both sides of the gully,we can conclude that 25~40° is more easily to form the landslide and more shallow slides were generated when the upper part of the slope is obviously more flat than the bottom of it.According to investigation,the Dahao gully can still outbreaks debris flow in the condition of strong rainfall after this disaste,but the scale will be reduced and it can still causes greater harm under the action of rare and heavy rain similar to\"6·06\".",
        "keywords": [
            "formation mechanism",
            "Dahao gully",
            "bank slope",
            "startup type",
            "debris flow"
        ],
        "authors": [
            {
                "name": "ZHU Yuan",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "CHEN Yuanjing",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "WANG Tao",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key Lab.of Geo-hazard Prevention and Geo-environment Protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "Journal of Mountain Science",
        "year": 2012
    },
    "rIjeCkAR": {
        "id": "rIjeCkAR",
        "title": "Characteristics of Longchi 8.13 Maliu gully debris flow disasters of in Dujiangyan,Sichuan Province",
        "abstract": "Maliu gully debris flow located in the right bank of Longxi river in Longchi town,Dujiangyan city.After \"5.12\"earthquake,basin of Maliu gully generated a lot of sliding masses and provide rich material resources.August 13,2010,Maliu gully has outbreak medium-sized debris flow under the action of heavy rainfall.Mizoguchi deposits amounted to 8 × 104m3,Damaged three resident’s houses and was buried Longchi scenic highway.Analysis of the formation conditions and basic characteristics of debris flow Maliu gully based on the field investigation at Sampling and measurement of flood marks Cross Section.By Calculated the density of debris flow,flow rate,Static and kinetic parameters,forecasting the development trend of the debris flow,and put forward appropriate prevention recommendations according to its hazard.",
        "keywords": [
            "Maliu gully debris flow",
            "basic features",
            "development trend",
            "static and kinetics parameters"
        ],
        "authors": [
            {
                "name": "QI Xing",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "MA Yu",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "WU Yu-fu",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology,Chengdu ,China"
            },
            {
                "name": "ZHANG Jian-nan",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology,Chengdu ,China"
            }
        ],
        "venue": "The Chinese Journal of Geological Hazard and Control",
        "year": 2011
    },
    "6EtjgzFX": {
        "id": "6EtjgzFX",
        "title": "Risk assessment of the debris flow hazards around the No.2 Yanghu hydropower plant",
        "abstract": "The debris flow hazards are common in the construction of the hydropower stations.The method of the analytic hierarchy process proposed by Saaty is applied in this study to the risk assessment of the debris flow hazards in five debris flow gullies around No.2 Yanghu hydropower plant,Xizang.The results of assessment show that there is the most potential risk in the 5th debris flow gully,followed by the 4th debris flow gully.Particular attention and reasonable suggestions should be taken in the design and construction of No.2 Yanghu hydropower plant.",
        "keywords": [
            "analytic hierarchy process",
            "engineering effect",
            "risk assessment",
            "debris flow"
        ],
        "authors": [
            {
                "name": "TIE Yong-bo",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "TANG Chuan",
                "org": "State Key Geological Hazard and Geological Environmental Protection,Chengdu University of Technology,Chengdu ,Sichuan,China"
            },
            {
                "name": "YU Bin",
                "org": "State Key Geological Hazard and Geological Environmental Protection,Chengdu University of Technology,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2009
    },
    "TutcRuvu": {
        "id": "TutcRuvu",
        "title": "Characteristics and prevention of debris flow in Tianba Gully of Wangmo County in Guizhou",
        "abstract": "Tianba Gully is debris flow of low frequency,And it broke out under the condition of heavy rain on June 6.This paper analyzes the sources,topography and rainfall condition,gets the flow velocity and flow parameters through the field sampling and section interception,forecasts the activities trends of Tianba Gully in the future and puts forward the related prevention and control of suggestions.",
        "keywords": [
            "Tianba Gully",
            "characteristics",
            "debris flow",
            "prevention advise"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology, Chengdu ,China"
            },
            {
                "name": "QI Xing",
                "org": "State Key laboratory of geohazards prevention and geoenvironment protection,Chengdu University of Technology, Chengdu ,China"
            },
            {
                "name": "MA Yu",
                "org": "College of Engineering and Technology,Chengdu University of Technology,Leshan ,China"
            }
        ],
        "venue": "The Chinese Journal of Geological Hazard and Control",
        "year": 2012
    },
    "aA6WCs6R": {
        "id": "aA6WCs6R",
        "title": "Effect of Saccharides on Texture of Lactone Tofu",
        "abstract": "In this study,glucose,maltodextrin,soluble starch and carrageen were added to lactone tofu to study change of texture of lactone tofu.The results showed that saccharides type and concentration significantly affected different characteristics of lactone tofu.Glucose had greater impact on springness,maltodextrin on cohesiveness and adhesiveness,soluble starch on hardness and chewiness,and carrageen on gumminess.Principal component analysis of SPSS indicated that the order of combined effect on texture of lactone tofu by four kinds of saccharides was as followed: carrageenan>soluble starch>glucose>maltodextrin.The molecular weight,structure and surface charge of saccharides were important factors affecting texture characteristics of lactone tofu.",
        "keywords": [
            "texture",
            "lactones tofu",
            "saccharides"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Department of Life Science,Zaozhuang College1,Zaozhuang "
            },
            {
                "name": "Wang Xibo",
                "org": "College of Food science,Northeast Agriculture University2,Harbin "
            }
        ],
        "venue": "Journal of the Chinese Cereals and Oils Association",
        "year": 2012
    },
    "TtbTNJIW": {
        "id": "TtbTNJIW",
        "title": "Correlation between Quality of Hen Egg and Gelling Properties of Albumin",
        "abstract": "Studies were conducted to evaluate the correlation between hen egg quality and gelling properties of albumin.Hen eggs were stored to investigate the weight loss,the Haugh unit,the content of dense albumin and the pH of albumin.The texture characteristic and the microstructure of gel from albumin were also tested during storage.The results showed that hen egg quality decreased with storage time,especially for higher temperature.The texture characteristic of gel from albumin increased with storage temperature.There was a significant correlation between hen egg quality and texture characteristic of gel from albumin,which had positive correlation to weight loss and pH of albumin,and negative correlation to the Haugh unit and the content of dense albumin.The microstructure of gel from albumin suggested variation of intermolecular force of proteins induced by decreasement of quality of hen egg changed the microstructure of gel from albumin and texture characteristic.The quality parameters could be used to indicate the change of the texture characteristic of gel from albumin during storage.",
        "keywords": [
            "texture characteristic",
            "hen egg",
            "quality",
            "correlation",
            "storage"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": " 1.Department of Life Science,Zaozhuang University(Zaozhuang ), 2.Department of Food Science,Northeast Agricultural University%%#Harbin %%#"
            },
            {
                "name": "Wang Xi-bo",
                "org": " 1.Department of Life Science,Zaozhuang University(Zaozhuang ), 2.Department of Food Science,Northeast Agricultural University%%#Harbin %%#"
            }
        ],
        "venue": "The Food Industry",
        "year": 2012
    },
    "Lv3ROU13": {
        "id": "Lv3ROU13",
        "title": "Review on the hydrolysis of plant polysaccharides and the structure of hydrolysate",
        "abstract": "As one of the important components in plants,polysaccharides is widely used because of its physiological activities.With the progresses in intensive study,more and more attention was given to the hydrolysis of polysaccharides and it was found that low molecular sugar has better activities than high molecular sugar in some ways.Reviews on the methods of polysaccharides hydrolysis and the structural identification were elaborated,providing basis for the relationship between hydrolysates and their physiological activities.",
        "keywords": [
            "structural identification",
            "hydrolysis",
            "plant polysaccharides"
        ],
        "authors": [
            {
                "name": "LI Dan-dan",
                "org": ""
            },
            {
                "name": "SONG Ye",
                "org": ""
            },
            {
                "name": "WU Mao-yu",
                "org": ""
            },
            {
                "name": "ZHU Feng-tao",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "MA Xiao-yan",
                "org": ""
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2013
    },
    "mE5Jdzbs": {
        "id": "mE5Jdzbs",
        "title": "Relationship between structure characteristics and gelling properties of thermo-modified egg white protein during storage",
        "abstract": "The relationship between gelling properties and structure characteristics of thermo-modified egg white protein(TMEWP)during storage was investigated.The results showed that the hardness and water holding capacity of the thermo-modified egg white protein was decreased by 56.88% and 21.76%,respectively,with 6 months of storage.The gel exhibited multiporous and loose microstructure.Surface hydrophobicity,surface and total sulfhydryl group of EWMH decreased by 35.19%,42.60% and 13.20% during storage.The result of circular dichroism spectra indicated that the secondary structure of the TMEWP changed slightly.The decreasement of tryptophan fluoresecence intersity of EWMH suggested the EWMH converted to compact conformation.The fold of structure was owing to the change of gelling properties of TEMWP.",
        "keywords": [
            "gelling properties",
            "egg white protein",
            "thermal modification",
            "structure characteristics"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Department of Life Science,Zaozhuang University,Zaozhuang ,China"
            },
            {
                "name": "WANG Xi-bo",
                "org": "College of Food Science,Northeast Agriculture University,Harbin ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2012
    },
    "P0bbPUlO": {
        "id": "P0bbPUlO",
        "title": "Ultrasound-surfactant synergistic extraction of saponins from balsam pear",
        "abstract": "Balsam pear (Momordica charantia L.), a climber belonging to family Cucurbitaceae, is commonly known as bitter gourd or bitter melon in English. It is cultivated throughout the world for use as vegetable as well as medicine. Balsam pear has been used traditionally as medicine in developing countries. Some of its common uses in most countries are for diabetes, a carminative and in treatment of colics. Topically it is used for treatment of wounds, internally as well as externally for management of worms and parasites. It is also used as emmenagogue, antiviral for measles and hepatitis. Balsam pear contains biologically active chemicals that include glycosides, saponins, alkaloids, fixedoils, triterpenes. Saponins from all parts of the plant (fruit pulp, seed, leaves and whole plant) are most widely studied with regard to its antidiabetic effect. Ultrasound and surfactants have been individually shown to enhance saponins extraction. In this study, we investigated the synergistic effect of ultrasound and surfactants on saponins extraction. In order to explore effective extracting method of saponins from balsam pear, response surface was used to study the effect of ultrasonic power (133-167 W/g), ethanol volume fraction (60%-80%) and mass concentrations of SDS (15-25 mg/mL) on extraction rate of saponins from balsam pear. Ultrasound-surfactant synergistic extraction was compared with ethanol and ultrasound, respectively. The structures of the prepared saponins from balsam pear were identified. Results showed that the established model of extraction could well predict extraction rate of saponins from balsam pear under different conditions. Extraction rate of saponins from balsam pear was significantly (p<0.05) influenced by ultrasonic power, ethanol volume fraction and mass concentrations of SDS, and there was synergistic effect between ultrasonic power and the mass concentration of SDS. Various factors affecting extraction rate of saponins from balsam pear in a descending order was as follows: mass concentrations of SDS, ultrasonic power, ethanol volume fraction. Extraction rate of saponins from balsam pear was 3.22% at ultrasonic power of 153 W/g, ethanol volume fraction of 74%, mass concentrations of SDS of 16 mg/mL, significantly higher (p<0.05) than that of ethanol and ultrasound extraction. Liquid chromatography-mass spectrometry revealed that extracted saponins included momordicoside L and F2 . Ultrasound-surfactant synergistic extraction is an effective method for extraction of saponins, which is worth further development and application.",
        "keywords": [
            "Models",
            "Optimization",
            "Saponins from balsam pear",
            "Structure identification",
            "Surfactant",
            "Synergic extraction",
            "Ultrasonic waves"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": " College of Life Science, Zaozhuang University, Zaozhuang , China; Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, Ji’nan , China"
            },
            {
                "name": "Ge Bangguo",
                "org": " Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, Ji’nan , China"
            },
            {
                "name": "Song Ye",
                "org": " Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, Ji’nan , China"
            },
            {
                "name": "Li Dandan",
                "org": " Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, Ji’nan , China"
            },
            {
                "name": "Ma Xiaoyan",
                "org": " Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, Ji’nan , China"
            },
            {
                "name": "Wu Maoyu",
                "org": " Jinan Fruit Research Institute, All China Federation of Supply and Marketing Cooperatives, Ji’nan , China"
            }
        ],
        "venue": "Transactions of the Chinese Society of Agricultural Engineering",
        "year": 2013
    },
    "6XHklQGM": {
        "id": "6XHklQGM",
        "title": "Progress in Structure and Physiological Activity of Lyciumbarbarum Polysaccharides",
        "abstract": "Lycium barbarum polysaccharides(LBP) is one of the main active constituents in Lycium barbarum L.It has a number of significant bioactivities,such as enhancing immunity,anti-cancer,anti-ageing,increasing the hematopoietic function,becomes one of the hot research topic in recent years.The progress in isolation,structure identification and the physiological activity of LBP was reviewed in this study for further study.",
        "keywords": [
            "physiological activity",
            "structure identification",
            "Lycium barbarum polysaccharides(LBP)"
        ],
        "authors": [
            {
                "name": "Li Dan-dan",
                "org": "School of Food & Bioengineering,Shandong Polytechnic University%%#Jinan %%#"
            },
            {
                "name": "Wu Mao-yu",
                "org": "Jinan Fruit Research Institute,All China Federation of Supply & Marketing Co-operatives%%#Jinan %%#"
            },
            {
                "name": "Yu Bin",
                "org": "Jinan Fruit Research Institute,All China Federation of Supply & Marketing Co-operatives%%#Jinan %%#"
            },
            {
                "name": "Zhu Feng-tao",
                "org": "Jinan Fruit Research Institute,All China Federation of Supply & Marketing Co-operatives%%#Jinan %%#"
            },
            {
                "name": "Song Ye",
                "org": "Jinan Fruit Research Institute,All China Federation of Supply & Marketing Co-operatives%%#Jinan %%#"
            }
        ],
        "venue": "The Food Industry",
        "year": 2013
    },
    "2GMGUUpm": {
        "id": "2GMGUUpm",
        "title": "Storage Stability of Egg White Powder Modified by Heating",
        "abstract": "Functional properties and molecular characteristics of egg white modified by heating(EWH) were studied to investigate the storage stability during the storage of 12 months at room temperature.The result showed that the gelling,emulsifying,foaming properties were decreased at the diffident degree,while the hydrophobicity,content of sulfhydryl group and molecule flexibility of EWH showed significant changes during the storage.Correlation analysis suggested the decrease of functional properties of EWH correlated with change of molecular characteristics significantly(p<0.05).Molecular characteristics of egg white protein was an important factor affected storage stability of EWH.",
        "keywords": [
            "storage stability",
            "functional properties",
            "molecular characteristic",
            "egg white powder"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Department of Life Science,Zaozhuang University,Zaozhuang ,China"
            },
            {
                "name": "Wang Xibo",
                "org": "College of Food Science,Northeast Agriculture University,Harbin ,China"
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2012
    },
    "GboOFVnT": {
        "id": "GboOFVnT",
        "title": "Performance Improvement in Estimating Direction-of-Arrival by Genetic Algorithm",
        "abstract": "Genetic algorithm is used for optimization the performance in estimation direction-of-arrival of linear array.In the process of optimization,not only the position of elements,but also the number is used as variable.This can provide more freedom to control characters of non-uniform linear array.It can use fewer elements to obtain the estimation accuracy of DOA.And it also can decrease the computation amounts and simplify equipment.The simulation results show the validity.",
        "keywords": [
            "Genetic algorithm",
            "Array antennas",
            "Space spectrum estimation",
            "Optimization"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "YIN Cheng-you",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "HUANG Ye",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            }
        ],
        "venue": "Journal of Microwaves",
        "year": 2007
    },
    "Q042cpQX": {
        "id": "Q042cpQX",
        "title": "Calibration method for mutual coupling between elements based on parallel genetic algorithm",
        "abstract": "For the arrays of high frequency ground wave radar, a method with a signal to estimate the mutual coupling coefficient of arrays was brought out, which was based on principle of signal subspace and utilizing the parallel genetic algorithm. After estimating the impedance matrix C precisely with an assistant source, mutual coupling can be counteracted effectively for any types of array. Computer simulation results show that the proposed method successfully counteracts mutual coupling and direction of arrival (DOA) of sources can be estimated precisely. Furthermore, as output voltage vector and objective function are obtained, this method can be adopted to solve the problems of channel mismatch and elements' position errors. © 2006 IEEE.",
        "keywords": [
            "doa",
            "genetic algorithm",
            "mutual coupling",
            "calibration",
            "direction of arrival",
            "genetic algorithms",
            "high frequency",
            "objective function",
            "computer simulation",
            "parallel algorithms"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "PLA Electronic Engineering Institute(Electronic Engineering Institute,Electronic Engineering Institute of PLA),Hefei,China"
            },
            {
                "name": "Yin Chengyou",
                "org": "PLA Electronic Engineering Institute(Electronic Engineering Institute,Electronic Engineering Institute of PLA),Hefei,China"
            },
            {
                "name": "Huang Ye",
                "org": "PLA Electronic Engineering Institute(Electronic Engineering Institute,Electronic Engineering Institute of PLA),Hefei,China"
            }
        ],
        "venue": "Proceedings of the World Congress on Intelligent Control and Automation (WCICA)",
        "year": 2006
    },
    "xmJaDTaW": {
        "id": "xmJaDTaW",
        "title": "Effect and Calibration of Array Errors Among Sensors in Direction-finding",
        "abstract": "Analysis the main factors of producing array errors which are mutual coupling among sensors,sensor position uncertainties,channel mismatch and their effect on direction-finding.Then get the theory calculating formula.Spatial smoothing technique and improved spatial smoothing technique are put forward to calibrate array errors.The computer simulation results demonstrate that they are correct and effective.",
        "keywords": [
            "sensor position uncertainties",
            "channel mismatch",
            "mutual coupling",
            "spatial smoothing technique"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "YIN Cheng-you",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "SHEN Hui",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2007
    },
    "UkVOsRdD": {
        "id": "UkVOsRdD",
        "title": "Performance Improvement of Estimation Direction-of-Arrival in Non-uniform Linear Antenna Array by Genetic Algorithm",
        "abstract": "This paper presents a new arrangement method for the non-uniform linear array by genetic algorithm.Genetic algorithm is a global search method, and it needs nothing except fitness function in its optimization process. The method of the paper makes fully use of this advantage to optimize the performance of non-uniform linear antenna with a source. And the DOA of the source must be known exactly in advance. Computer simulation results indicate there is great improvement in estimation DOA by optimized non-uniform linear antenna array, which has proved validity of this method.",
        "keywords": [
            "DOA estimation",
            "genetic algorithm",
            "non-uniform linear antenna array"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Department of Information Engineering, Electronic Engineering Institute of PLA, Hefei "
            },
            {
                "name": "Yin Chengyou",
                "org": "Department of Information Engineering, Electronic Engineering Institute of PLA, Hefei "
            },
            {
                "name": "Song Zheng",
                "org": "Department of Information Engineering, Electronic Engineering Institute of PLA, Hefei "
            },
            {
                "name": "Huang Ye",
                "org": "Department of Information Engineering, Electronic Engineering Institute of PLA, Hefei "
            }
        ],
        "venue": "Communications Technology",
        "year": 2005
    },
    "maYnux5m": {
        "id": "maYnux5m",
        "title": "Effect of antenna directional error on DOA estimation and its calibration",
        "abstract": "The directional error of antenna array element may cause performance degrading of DOA estimation algorithm based on eigenvalue decomposition.Thus it is necessary to correct the directional errors.The mathematical models for analyzing DOA estimation when there is directional error are established.It is put forward to use spatial smoothing technique and improved spatial smoothing technique for calibrating directional error.The computer simulation results demonstrate that the main effect of directional errors on DOA estimation is that it reduces the peak of spectrum.Spatial smoothing technique and improved spatial smoothing technique can calibrate the directional errors effectively.",
        "keywords": [
            "spatial smoothing",
            "DOA",
            "error",
            "calibration"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "YIN Cheng-you",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "HUANG Ye",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "LUO Huai-zhong",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            }
        ],
        "venue": "Electronics Optics & Control",
        "year": 2007
    },
    "00aeUb8M": {
        "id": "00aeUb8M",
        "title": "Application of Genetic Algorithms in Calibration Errors and Optimization Performance of Array Antenna",
        "abstract": "Aimed at the effect of position errors on performance of DOA estimation algorithm,a method based on genetic algorithm is put forward.Also the case of certain number elements,the scope variable and the scope being certain but number variable how to make use of genetic algorithms to optimize the performance of array antenna is studied.At last,the simulating results are given which verified its correctness and usefulness.",
        "keywords": [
            "DOA estimate",
            "array antenna",
            "genetic algorithm",
            "optimization"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "PLA,Inst.of Electronic Engineering,Anhui Hefei ,China"
            },
            {
                "name": "HUANG Cheng-dong",
                "org": "PLA,NO.63892 Troop,Henan Luoyang ,China"
            }
        ],
        "venue": "Modern Defence Technology",
        "year": 2007
    },
    "nAojK1Nf": {
        "id": "nAojK1Nf",
        "title": "Direction of Arrival(DOA) Estimation for an Array with Errors Using RBF Neural Network",
        "abstract": "A novel direction finding system based on radial-basis function neural network is proposed to solve the problem of direction of arrival estimation for an array with system errors(mutual coupling and mismatching).Through calibration of input data with direct data domain algorithm,the correct centers of radial-basis function can be obtained.Direction of arrival can be estimated without improving the radial-basis function neural network DOA estimation system.In order to reduce the dimension of input vectors,the symmetry property in the correlation matrix is utilized.Only the upper triangular half of the correlation matrix is used in processing.The specific steps are presented.The simulation results demonstrated that this DOA estimation system has very high precision.",
        "keywords": [
            "Radial basis function(RBF)",
            "Direction of arrival",
            "Directional errors",
            "Neural network"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "YIN Cheng-you",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "Huang Ye",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            }
        ],
        "venue": "Journal of Microwaves",
        "year": 2007
    },
    "hluQg2hx": {
        "id": "hluQg2hx",
        "title": "A New Method for Antenna Array Position Correction",
        "abstract": "A new method called dummy elements is put forward to solve the problem of antenna array position errors.This method makes use of a signal and genetic algorithm to get the position of dummy elements for resuming the space spectrum,but not from calibrating the errors of senor positions.The simulated results indicates that resumed spectrum can precisely detect signal.And this method can be used in any form antenna array.",
        "keywords": [
            "DOA estimation",
            "snsor psition error",
            "genetic agorithm",
            "atenna array"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "HUANG Cheng-dong",
                "org": "No.63892 of PLA,Luoyang ,China"
            }
        ],
        "venue": "Journal of Detection & Control",
        "year": 2006
    },
    "a6sVxuZK": {
        "id": "a6sVxuZK",
        "title": "Calibration Method for Mutual Coupling,Sensor Position Uncertainty and Channel Mismatch",
        "abstract": "This paper presents a problem of array calibration in the presence of errors in the array manifold due to the combined effect of mutual coupling,sensor position errors and channel mismatch.After the calculation of mutual coupling matrix and compensate it,the sensor position,gain and phase can be estimated accurately.And the array manifold can be formed with the estimated parameters.In both general conditions and complex cases,the proposed algorithm can solve the problem that the functions are difficult to converge.The simulated results show that this method is effective and robust.",
        "keywords": [
            "Direction finding",
            "Mutual coupling",
            "Position uncertainty",
            "Channel mismatch"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "YIN Cheng-you",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "HUANG Ye",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            }
        ],
        "venue": "Journal of Microwaves",
        "year": 2008
    },
    "VAcmxfar": {
        "id": "VAcmxfar",
        "title": "Calibration for Array Position Uncertainties Based on Simulated Annealing",
        "abstract": "The uncertainties of array element position affect phase of received array signal.DOA estimation algorithm based on eigenvalue decomposition is very sensitive to phase error of array signal.Thus,it is necessary to calibrate signal phase error brought by array element position error.From the objective function based on signal subspace,a calibration method is put forward which can calibrate error effectively.And it can be applied to any pattern of array.The simulated results prove it is effective.",
        "keywords": [
            "array antenna",
            "simulated annealing",
            "position error",
            "calibration"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "YIN Cheng-you",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            },
            {
                "name": "HUANG Ye",
                "org": "Electronic Engineering Institute of PLA,Hefei ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2007
    },
    "S19sKZF7": {
        "id": "S19sKZF7",
        "title": "Effect of Added Potassium Salt on Preparation of Potassium Niobate by Hydrothermal Processing",
        "abstract": "The potassium niobate(KNbO3)is prepared with niobium oxide(Nb2O5)and potassium hydroxide(KOH)as source material by hydrothermal method,which adds different kinds of potassium salt,for example,KCL,K2SO4,K2CO3,KBr.The influence of different potassiums on crystal texture,microstructure,output and fluorescence of the complex KNbO3is studied by X-ray diffraction(XRD),Raman spectrum,scanning electron microscope(SEM),infrared spectroscopy(FTIR)and fluorescence spectra(PL).Results show that the productivity is improved greatly by the adding of potassium salt.The kind of potassium salt is a critical factor for the structure and morphological profile of the KNbO3.When the added potassium salt is KCl or KBr,the well crystallized KNbO3rods whose structures are rhombohedral and ortho rhombic form respectively are formed with the width of 0.5~1μm and the length of 1~10μm.Using K2CO3or K2SO4as the added potassium salt,the formed KNbO3crystals whose structure are rhombohedral and ortho rhombic form respectively are irregular granular structures instead of rod-like structures.FTIR results indicate that the crystal show Nb=O and Nb-O-Nb vibration peaks at 1383,1087,1050, 879,614 cm-1.The fluorescence emissions of the KNbO3 samples are detected to appear the characteristic peaks at the wavelengths of 396,450,467,481,491 nm.",
        "keywords": [
            "Fluorescence",
            "Hydrothermal method",
            "Materials",
            "Potassium niobate"
        ],
        "authors": [
            {
                "name": "Cao Bo",
                "org": ""
            },
            {
                "name": "Yu Jie",
                "org": ""
            },
            {
                "name": "Yu Bin",
                "org": ""
            },
            {
                "name": "Zhang Xinpeng",
                "org": ""
            },
            {
                "name": "You Cheng",
                "org": ""
            },
            {
                "name": "Chen Junwen",
                "org": ""
            },
            {
                "name": "Cao Huiqun",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Lasers",
        "year": 2013
    },
    "5g9KWOEc": {
        "id": "5g9KWOEc",
        "title": "Known-plaintext attack on optical encryption based on double random phase keys.",
        "abstract": "We demonstrate a new approach to known-plaintext attack on an optical encryption scheme based on double random phase keys. With this attack an opponent can access both random phase keys with the help of the phase retrieval technique. This demonstration shows that an optical encryption scheme based on double random encoding is vulnerable to known-plaintext attack.",
        "keywords": [
            "RETRIEVAL",
            "IMAGE",
            "ALGORITHM",
            "PLANE"
        ],
        "authors": [
            {
                "name": "Xiang Peng",
                "org": ""
            },
            {
                "name": "Peng Zhang",
                "org": ""
            },
            {
                "name": "Hengzheng Wei",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2006
    },
    "UiPakSxE": {
        "id": "UiPakSxE",
        "title": "Super-resolution fluorescence blinking imaging using modified Fourier ptychography.",
        "abstract": "In this paper, we propose a new super-resolution imaging technique based on fluorescence blinking (SRFB). Contrary to structured illumination microscopy (SIM), SRFB considers the time-varying fluorescence distribution under a suitable density as the varying illuminated speckle pattern, and therefore, external speckle patterns or diffusers are not required. With several images recorded at different times, a super-resolution image can be obtained through an iterative algorithm modified from Fourier ptychography. Recorded image sequences in a microscopy imaging experiment based on photo switching or fluorescence blinking effects, such as STORM and SOFI, can be handled with SRFB and used to recover a super-resolution image. The simulation and experimental results confirm that the SRFB scheme can surpass the diffraction limit by a factor greater than two.",
        "keywords": "",
        "authors": [
            {
                "name": "Jingjing Wu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"
            },
            {
                "name": "Bin Yu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"
            },
            {
                "name": "Saiwen Zhang",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"
            },
            {
                "name": "Siwei Li",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"
            },
            {
                "name": "Xuehua Wang",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"
            },
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China"
            }
        ],
        "venue": "Optics express",
        "year": 2018
    },
    "tcfoRpMW": {
        "id": "tcfoRpMW",
        "title": "Known-plaintext attack on double phase encoding encryption technique",
        "abstract": "In the field of optical information security, the most attractive work is the so-called double-random-phase encoding encryption scheme proposed by Javidi. However, the security of this cryptosystem has not been analyzed thoroughly from the point of view of cryptoanalysis. In this article, the weakness of Javidi's optical security system is carefully analyzed with a known-plain text attack. It is shown that the double-random-phase encoding encryption scheme is a linear symmetric block cipher cryptosystem and its linearity opens avenues of attacks. Under the known-plaintext attack, attacker can obtain the phase key (s) in the input plane using the typical phase retrieval algorithms and subsequently deduce the phase key (s) in the Fourier domain easily. In addition, an optical implementation of known-plain text attack is also proposed.",
        "keywords": [
            "RETRIEVAL",
            "WATERMARKING",
            "ALGORITHMS",
            "SYSTEM",
            "IMAGE",
            "PLANE"
        ],
        "authors": [
            {
                "name": "Xiang Peng",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Peng Zhang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Wei Heng-Zheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2006
    },
    "fjgrW8Yr": {
        "id": "fjgrW8Yr",
        "title": "Background suppression by axially selective activation in single-molecule localization microscopy.",
        "abstract": "Resolution of a few tens of nanometers has been achieved in fluorescence microscopy with photoswitchable molecules. However, for thick samples, the background brought by the crosstalk of unwanted on-state molecules is nonnegligible. Now we present a background suppression method by using two axial standing waves generated by the interference of two activation beams with the same phases and two deactivation beams with the opposite phases. With spatially incoherent illumination, most activated molecules are located in a thin layer. The performance of such method is simulated with the known photoswitching characteristic of Cy5. With suitable parameters, the thickness of the layer can reach 39 nm (FWHM).",
        "keywords": [
            "FLUORESCENCE MICROSCOPY",
            "DIFFRACTION-LIMIT",
            "RESOLUTION",
            "SAMPLES",
            "STORM"
        ],
        "authors": [
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2010
    },
    "rCRdxCgK": {
        "id": "rCRdxCgK",
        "title": "Fast Fourier-domain localization algorithm of single molecule with nanometer resolution for super-resolution fluorescence imaging",
        "abstract": "In order to improve the computational speed and prior background noise-dependent problem of single molecule localization algorithm, a Fourier domain localization scheme based on zero-padded fast Fourier transform and phase gradient operators is used to obtain a powerful mathematical model for localizing a single molecule without numerical fitting. Numerical simulations indicate that the proposed method exhibits nanometer scale localization precision while executing almost as fast as the fluoroBancroft algorithm. Furthermore, a sample consisted of several lines of molecules are simulated imaged. The results demonstrate that two lines of molecules separated by 30 nm can be resolved. Finally, super-resolution images of filopodia in HeLa cells are reconstructed based on the method, in which filopodia with diameter of 75-200 nm are resolved.",
        "keywords": [
            "Filopodia",
            "Microscopy",
            "Phase gradient",
            "Single molecule localization",
            "Super-resolution imaging"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Danni Chen",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Lei Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Junle Qu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Hanben Niu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Guangxue Xuebao/Acta Optica Sinica",
        "year": 2012
    },
    "VNCLIc8y": {
        "id": "VNCLIc8y",
        "title": "Nano-resolution imaging of filopodia in HeLa cells",
        "abstract": "Nano-resolution imaging based on single molecule localization is simulated with Matlab. A sample consisted of several lines of molecules are simulated imaged. The results demonstrate that two lines of molecules separated by 20 nm can be resolved. Effect of pixel size on the localization accuracy is also discussed here. Nano-resolution imaging is realized on an IX71 inverted fluorescent microscope with the resolution (FWHM) of 48 nm. Nano-resolution images of filopodias are reconstructed, in which filopodias with diameter of 75 nm are resolved. © 2010 Chin.Phys.Soc.",
        "keywords": [
            "FLUORESCENT-PROBES",
            "MICROSCOPY"
        ],
        "authors": [
            {
                "name": "Chen Dan-Ni",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Lei Liu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Bin Yu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Niu Han-Ben",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2010
    },
    "KawY8eHf": {
        "id": "KawY8eHf",
        "title": "Deconvolution optimization in super-resolution optical fluctuation imaging based on cumulant standard deviation",
        "abstract": "The super-resolution optical fluctuation imaging (SOFI) technique enhances image spatial resolution by evaluating the independent stochastic intensity fluctuations of emitters. In principle, it eliminates any noise uncorrelated temporally, and provides unlimited spatial resolution since the calculation of the nth-order cumulant followed by a deconvolution results in an image with n-fold resolution improvement in three dimensions. But in practice, due to limited data length, the statistical uncertainty of cumulants will affect the continuity and homogeneity of SOFI image, which results in the fact that the high order SOFI (typically over 3rd order) cannot improve spatial resolution significantly. Since the variance characterizes the statistical uncertainty of cumulant, we deduce its theoretical expression based on a single dataset. In traditional SOFI techniques, due to lack of statistical analysis of cumulant, there is no noise constraint condition of cumulant in the Lucy-Richardson deconvolution to prevent the algorithm from causing noise amplification. In this paper, based on the cumulant variance formula, we calculate the cumulant standard deviation in each pixel of SOFI image and introduce the results into the Lucy-Richardson algorithm as a DAMPAR to suppress the noise generation in such pixels. The simulation and experimental results show that under the same data length, the deconvolution optimization based on cumulant standard deviation significantly improves the uniformity and continuity of SOFI image. On the other hand, under the premise of identical image quality, this optimization technique can also greatly shorten the image frames to less than half the original, thus promoting the development of super-resolution imaging of living cells.",
        "keywords": [
            "SOFI",
            "RECONSTRUCTION",
            "SPECTROSCOPY",
            "RESOLUTION",
            "STORM"
        ],
        "authors": [
            {
                "name": "Wang Xue-Hua",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Biomed Engn, Key Lab Optoelect Devices &amp; Syst,Minist Educ &amp; Gu, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen Dan-Ni",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Biomed Engn, Key Lab Optoelect Devices &amp; Syst,Minist Educ &amp; Gu, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu Bin",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Biomed Engn, Key Lab Optoelect Devices &amp; Syst,Minist Educ &amp; Gu, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Niu Han-Ben",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Biomed Engn, Key Lab Optoelect Devices &amp; Syst,Minist Educ &amp; Gu, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "ACTA PHYSICA SINICA",
        "year": 2016
    },
    "geN1s6vD": {
        "id": "geN1s6vD",
        "title": "Obligate anaerobic Salmonella typhimurium strain YB1 treatment on xenograft tumor in immunocompetent mouse model.",
        "abstract": "The present authors have previously reported a novel approach to genetically engineer Salmonella typhimurium for the medically important therapeutic strategy of using bacterial agents to target malignant tumors in a breast cancer tumor-bearing nude mouse model. However, studying an immunocompromised mouse model for cancer therapy is insufficient, as certain crucial information about the influence of the immune system may be missing. In the present study, inoculation of the Salmonella strain, YB1, into a colon cancer tumor-bearing immunocompetent mouse model was investigated. The present study determined the tumor targeting efficiency, antitumor potential, the effects of multiple treatments and the systemic toxicity. Intravenous inoculation of YB1 in BALB/c mice exhibited high antitumor effects and also greatly increased the tumor targeting ability and safety compared with the previously-reported nude mouse model. In addition, repeated administration of YB1 further enhanced this effect. Furthermore, no marked toxicity was observed with YB1 treatment, while the VNP20009 and SL7207 strains demonstrated certain adverse effects. The findings of the present study indicate that the YB1 strain is effective and safe in targeting a colon cancer tumor in an immunocompetent mouse model.",
        "keywords": [
            "GENE-THERAPY",
            "BIFIDOBACTERIUM-LONGUM",
            "CANCER-IMMUNOTHERAPY",
            "DELIVERY-SYSTEM",
            "SOLID TUMORS",
            "IN-VIVO",
            "HYPOXIA",
            "BACTERIA",
            "CELLS",
            "METASTASIS"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China ; Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR, P.R. China."
            },
            {
                "name": "Lei Shi",
                "org": "Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR, P.R. China."
            },
            {
                "name": "Bao-Zhong Zhang",
                "org": "Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, SAR, P.R. China."
            },
            {
                "name": "K E Zhang",
                "org": "Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong, SAR, P.R. China."
            },
            {
                "name": "Xiao Peng",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China."
            },
            {
                "name": "Han-Ben Niu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China."
            },
            {
                "name": "Jun-LE Qu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong 518060, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2015
    },
    "Gai34ofi": {
        "id": "Gai34ofi",
        "title": "Statistical precision in super-resolution optical fluctuation imaging",
        "abstract": "The super-resolution optical fluctuation imaging (SOFI) technique enhances image spatial resolution by calculating the spatiotemporal cross-cumulants of independent stochastic intensity fluctuations of emitters. Ideally, SOFI eliminates any noise that is not correlated over time, but in practice, due to limited data lengths, the statistical uncertainty of cumulants will affect the continuities and homogeneities of SOFI images. Since the variance and signal-to-noise ratio (SNR) characterize cumulant statistical uncertainty, we determined theoretical expressions for these based on a single dataset. From a simulation of temporal fluctuations of blinking fluorescent emitters, we calculated the quantitative relation between the SNR of cumulants and multiple parameters of the blinking signal, such as the on-time ratio, acquisition frame to average blinking rate ratio, sequence length, and photon amplitude, which not only provides a physical interpretation for SOFI phenomena but also theoretical guidance to achieve optimal practical outcomes. (C) 2016 Optical Society of America",
        "keywords": [
            "THICK SAMPLES",
            "NANOSCOPY",
            "SOFI",
            "RESOLUTION",
            "SPECTROSCOPY",
            "MICROSCOPY",
            "TRACKING",
            "STORM",
            "FIELD"
        ],
        "authors": [
            {
                "name": "Wang, Xuehua",
                "org": "Shenzhen Univ, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen, Danni",
                "org": "Shenzhen Univ, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu, Bin",
                "org": "Shenzhen Univ, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Niu, Hanben",
                "org": "Shenzhen Univ, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "APPLIED OPTICS",
        "year": 2016
    },
    "xL3ihGZL": {
        "id": "xL3ihGZL",
        "title": "Super-diffraction imaging in three-dimensional localization precision of the double-helix point spread function",
        "abstract": "The combination of switch effect and single molecule positioning can realize the sample super diffraction resolution imaging, and double helix point spread function will be a single molecular orientation nanometer resolution extending from two dimensions to three dimensions. In this paper, three-dimensional (3D) positioning accuracy of the double helix point spread function is discussed. First, the theoretical localization accuracy for an unbiased estimator of the double-helix point spread function is compared with that for 3D localization using Fisher information and the influences of localization accuracy including photon number, varying levels of background and pixel size are analyzed. Second, based on the localization algorithm of gaussian fitting, which is usually adopted in data analysis of single molecular orientation in the experimental process, the axial localization accuracy of double helix point spread function is obtained by the error transfer function law. Computer simulation results show that under the condition of more than 1000 photons in number, the positioning accuracy of gaussian fitting localization algorithm and theory localization accuracy of Fisher information are in good agreement. The discussion of the paper provides not only the theoretical basis for 3D positioning accuracy of double helix point spread function, but also the theoretical guidance for the experiment at the same time.",
        "keywords": [
            "MICROSCOPY",
            "TRACKING",
            "ACCURACY",
            "CELLS"
        ],
        "authors": [
            {
                "name": "Chen He",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Optoelect Devices &amp; Syst Minist Educ Guangdong, Key Lab, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu Bin",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Optoelect Devices &amp; Syst Minist Educ Guangdong, Key Lab, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen Dan-Ni",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Optoelect Devices &amp; Syst Minist Educ Guangdong, Key Lab, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Li Heng",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Optoelect Devices &amp; Syst Minist Educ Guangdong, Key Lab, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Niu Han-Ben",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Optoelect Devices &amp; Syst Minist Educ Guangdong, Key Lab, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "ACTA PHYSICA SINICA",
        "year": 2013
    },
    "3D9P5Lcl": {
        "id": "3D9P5Lcl",
        "title": "Three dimensional multi-molecule tracking in thick samples with extended depth-of-field.",
        "abstract": "We present a non-z-scanning multi-molecule tracking system with nano-resolution in all three dimensions and extended depth of field (DOF), which based on distorted grating (DG) and double-helix point spread function (DH-PSF) combination microscopy (DDCM). The critical component in DDCM is a custom designed composite phase mask (PM) combining the functions of DG and DH-PSF. The localization precision and the effective DOF of the home-built DDCM system based on the designed PM were tested. Our experimental results show that the three-dimensional (3D) localization precision for the three diffraction orders of the grating are σ(-1st)(x, y, z) = (6.5 nm, 9.2nm, 23.4 nm), σ(0th)(x, y, z) = (3.7 nm, 2.8nm, 10.3 nm), and σ(+1s)(x, y, z) = (5.8 nm, 6.9 nm, 18.4 nm), respectively. Furthermore, the total effective DOF of the DDCM system is extended to 14 μm. Tracking experiment demonstrated that beads separated over 12 μm along the axial direction at some instants can be localized and tracked successfully.",
        "keywords": [
            "SINGLE-PARTICLE TRACKING",
            "OPTICAL RECONSTRUCTION MICROSCOPY",
            "POINT-SPREAD FUNCTION",
            "PLANE MICROSCOPY",
            "SUPERRESOLUTION MICROSCOPY",
            "DIFFRACTION-LIMIT",
            "POLYMER DOTS",
            "LOCALIZATION",
            "CELLS",
            "ACCURACY"
        ],
        "authors": [
            {
                "name": "Heng Li",
                "org": ""
            },
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Gaixia Xu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2015
    },
    "gqdjAWcx": {
        "id": "gqdjAWcx",
        "title": "Sectioned imaging of DMD-based structured illumination fluorescence microscopy",
        "abstract": "In our novel structured illumination microscope (SIM), a programmable digital micromirror device (DMD) was used instead of piezo activated grating to produce stable and reliable structured illumination. An optical low-pass spatial filter was applied to block the diffraction order higher than ±1st order. The illumination pattern was not a sinusoidal grid with a single spatial frequency, so the algorithm used in the traditional SIM is not proper here. An improved algorithm based on the five raw images with different phase angles was introduced and discussed in detail. The results have demonstrated that the sectioned image can be reconstructed from five raw images with different phase angles, with resolving some fine lateral structure that was blurred in traditional microscopic image.",
        "keywords": [
            "Digital micromirror device",
            "Resolution",
            "Sectioned imaging",
            "Structured illumination microscopy"
        ],
        "authors": [
            {
                "name": "CHEN Dan-ni",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xia Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "QU Jun-le",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Niu Hanben",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Shenzhen Daxue Xuebao (Ligong Ban)/Journal of Shenzhen University Science and Engineering",
        "year": 2008
    },
    "vzUBBTR8": {
        "id": "vzUBBTR8",
        "title": "Synthesis and nonlinear optical properties of single-crystalline KNb 3O8 nanowires",
        "abstract": "Single-crystalline KNb3O8 nanowires with widths of 100-300 nm and lengths up to tens of microns were synthesized by calcining Nb2O5 powders in molten KCl and K2SO 4. The phase of the products was determined by means of x-ray diffraction, and the morphology and structure were characterized by using scanning electron microscopy, transmission electron microscopy, high resolution transmission electron microscopy and selected area electron diffraction techniques. The growth direction of the KNb3O8 obtained was determined to be the [001] crystallographic direction. Meanwhile, the polarization response of the second-harmonic generation (SHG) response was investigated. The as-synthesized nanowires clearly exhibited a SHG response, which means that the nanowires were an efficient nanoscale second-harmonic light source. The excellent nonlinear optical property of KNb3O 8 shows potential for application in nano-optical devices. © 2013 IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Bo Cao",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Huiqun Cao",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xinpeng Zhang",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Danni Chen",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Junle Qu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Hanben Niu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Nanotechnology",
        "year": 2013
    },
    "mYRUXjDj": {
        "id": "mYRUXjDj",
        "title": "Synthesis of Single-crystalline KNbO3 Nanowires with a Sacrificial Template Method and Their Second Harmonic Generation Response",
        "abstract": "High yield orthorhombic single-crystalline KNbO3 nanowires with widths of 60 similar to 150 nm and lengths up to a few microns were synthesized, using Nb2O5 nanobelts as reactants as well as templates via the hydrothermal process. The products were determined by XRD, and the morphology and the structure were characterized by SEM, TEM, HRTEM, and SAED techniques. The growth direction of KNbO3 was determined to be the [001] crystallographic direction. Results show that synthesized nanowires exhibit a second harmonic generation (SHG) response, an efficient nanoscale second harmonic light source. The excellent nonlinear optical properties of KNbO3 have potential applications in nano-optical devices.",
        "keywords": [
            "HYDROTHERMAL SYNTHESIS",
            "WATER",
            "NANORODS",
            "NIOBATES",
            "POWDERS"
        ],
        "authors": [
            {
                "name": "Cao Huiqun",
                "org": "Shenzhen Univ, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "You Cheng",
                "org": "Shenzhen Univ, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu Jie",
                "org": "Shenzhen Univ, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Cao Bo",
                "org": "Shenzhen Univ, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Xin Hong",
                "org": "Shenzhen Univ, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu Bin",
                "org": "Shenzhen Univ, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "RARE METAL MATERIALS AND ENGINEERING",
        "year": 2016
    },
    "Ni9Loi4d": {
        "id": "Ni9Loi4d",
        "title": "Preparation and Fluorescence Properties of Rod Potassium Triniobate Crystals",
        "abstract": "Potassium niobate crystals had been synthesized by a molten salt process with KCl,K2SO4 and Nb2O5 as materials.The effect of reactive temperature and reactive time on the structure and morphology of the powders were discussed,and the optical properties of the samples were studied.The reactive process had not begun when the reactive temperature was 700℃.A small amount of rod and some bulk KNb3O8 crystals were formed,when the sample was treated at 800℃ for 2 hours.A large amount of rod KNb3O8 crystals were formed,when the sample was treated at 900℃ for 1 hour.When the reactive time increased to 2 and 3 hours,the width of the nanorods was 200～300nm and their length was several microns.Their width was around 500nm,their maximum length was tens of microns and their surface was smooth when the reactive time increased to 4 hours.Fluorescence spectra showed that two fluorescence peaks appeared at near 250.0nm and 500.5nm when the reactive temperature of the samples was 900℃,and the KNb3O8 crystals had fluorescence.",
        "keywords": [
            "molten salt process",
            "rod",
            "preparation",
            "fluorescence",
            "potassium triniobate"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Optoelectronic Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "CAO Bo",
                "org": "College of Optoelectronic Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "CAO Huiqun",
                "org": "College ofChemistry and Chemical Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "ZHANG Shengjie",
                "org": "College ofChemistry and Chemical Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "LIN Ping",
                "org": "College ofChemistry and Chemical Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "ZHANG Anxiang",
                "org": "College ofChemistry and Chemical Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "LUO Zhongkuan",
                "org": "College ofChemistry and Chemical Engineering,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "ZHANG Tao",
                "org": "Key Laboratory ofInorganic Coating Materials,Chinese Academy of Sciences,shanghai ,China"
            }
        ],
        "venue": "Journal of Ceramics",
        "year": 2012
    },
    "lyW3UTB0": {
        "id": "lyW3UTB0",
        "title": "Approach to multiparticle parallel tracking in thick samples with three-dimensional nanoresolution.",
        "abstract": "This Letter proposes a method referred to as distorted grating (DG) and double-helix point spread function (DH-PSF) combination microscopy (DDCM), which is capable of multiparticle parallel localization and tracking in a transparent sample thicker than 10 μm, the thickness of cells. A special phase mask, combining the field depth extension capabilities of DG with the three-dimensional (3D) nanolocalization capabilities of the DH-PSF, is designed for multiparticle parallel localization. Time-lapse tracking of one particle moving along the z axis and parallel tracking of two particles are simulated. Results demonstrate that, with only a single snapshot, particles can be localized, tracking with 3D nanoresolution wherever they are. The theoretical localization precisions of DDCM, DH-PSF, and multifocus microscopy are compared. DDCM results in almost constant localization precisions in all three dimensions for a depth of field larger than 10 μm. DDCM is expected to become a tool in investigations of important dynamic events in living cells.",
        "keywords": [
            "OPTICAL RECONSTRUCTION MICROSCOPY",
            "MULTIFOCAL PLANE MICROSCOPY",
            "POINT-SPREAD FUNCTION",
            "FLUORESCENCE MICROSCOPY",
            "LOCALIZATION ACCURACY",
            "DIFFRACTION-LIMIT",
            "CELLULAR-DYNAMICS",
            "FOCAL PLANES",
            "3D"
        ],
        "authors": [
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Heng Li",
                "org": ""
            },
            {
                "name": "Yingdong Huo",
                "org": ""
            },
            {
                "name": "Bo Cao",
                "org": ""
            },
            {
                "name": "Gaixia Xu",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2013
    },
    "C3vjptPv": {
        "id": "C3vjptPv",
        "title": "Synthesis of KxNa1-xNbO3 Nanocrystals by Hydrothermal Method",
        "abstract": "The needle-like and dendrimer KxNa1-xNbO3 nanocrystals were synthesized through hydrothermal reaction by Nb2O5 and (1-x)NaOH-xKOH as raw materials. The change of structure and morphology were discussed with reactive conditions. The XRD study indicates that KxNa1-xNbO3 with single-phase perovskite structure can be formed at a low temperature as 150 degrees C. The SEM images show that the needle-like and dendrimer KxNa1-xNbO3 nanocrystals are only synthesized for the specimen with x=0.15. Nb2O5 powders and (1-x)NaOH-xKOH are heated at 150 degrees C for 5 d to form the needle-like KxNa1-xNbO3 with widths of 50 similar to 200 nm. Nb2O5 nanobelts and KOH are heated at 150 degrees C for 1 d to form the dendrimer KxNa1-xNbO3 with widths of 50 similar to 150 nm. The Nb2O5 nanobelts can act as template in the templated grain growth process. With the increase of x, the morphology of needle-like and dendrimer KxNa1-xNbO3 nanocrystals will become into KxNa1-xNbO3 nanoparticles.",
        "keywords": [
            "DENDRITIC NANOSTRUCTURES",
            "FRACTAL NANOSTRUCTURES",
            "GROWTH",
            "NANORODS"
        ],
        "authors": [
            {
                "name": "Cao Huiqun",
                "org": "Shenzhen Univ, Key Lab New Lithium Ion Battery &amp; Mesoporous Mat, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Bing, Lu",
                "org": "Shenzhen Univ, Key Lab New Lithium Ion Battery &amp; Mesoporous Mat, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Cheng, You",
                "org": "Shenzhen Univ, Key Lab New Lithium Ion Battery &amp; Mesoporous Mat, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Hong, Xin",
                "org": "Shenzhen Univ, Key Lab New Lithium Ion Battery &amp; Mesoporous Mat, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Jie, Yu",
                "org": "Shenzhen Univ, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Bo, Cao",
                "org": "Shenzhen Univ, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Bin, Yu",
                "org": "Shenzhen Univ, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "RARE METAL MATERIALS AND ENGINEERING",
        "year": 2016
    },
    "2o64QIxs": {
        "id": "2o64QIxs",
        "title": "Influence on different kinds of molten salt on synthesis and optical properties of the potassium niobium impact research",
        "abstract": "Potassium niobate crystals have been synthesized by a molten salt process with KCl, K 2SO 4, K 2CO 3 or KNO 3 as molten salt reactive Nb 2O 5 materials at 900°C for 2 h. The effect of different kinds of molten salt on the structure and morphological profile of the powers were discussed, and the optical properties of the samples were studied. X-ray diffraction results showed that the product is KNb 3O 8 when the KCl and K 2SO 4 as molten salt, respectively, and the product is K 2NbO 4 when the K 2CO 3 and KNO 3 as molten salt, respectively. Scanning electron microscopy results showed that bar was formed with the width of 0.2-0.5 μm and the length of several microns. Using K 2SO 4 as molten salt, the width of rod is 0.2-1 μm and the length is 1-25 μm. Using K 2CO 3 as molten salt, the product is not rod-like structure, but irregular granular structure. Using KNO 3 as molten salt, the width of rod is 0.2-1 μm and the length is 0.5-4 μm. Part of the rod-like structure connected together. Fluorescence spectra showed that KNb 3O 8 and K 3NbO 4 crystals have good fluorescence. Fluorescence studies have shown that the samples have very similar fluorescence spectra with K 2SO 4, KNO 3 and K 2CO 3 as the molten salt. The samples have good fluorescence which were prepared using KCl, K 2SO 4 and K 2CO 3 as molten salt.",
        "keywords": [
            "Molten salt process",
            "Optical material",
            "Potassium niobate"
        ],
        "authors": [
            {
                "name": "Huiqun Cao",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xinpeng Zhang",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Bo Cao",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Ping Lin",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xin Lin",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Anxiang Zhang",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Zhongkuan Luo",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xiqing Zhang",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Zhongguo Jiguang/Chinese Journal of Lasers",
        "year": 2011
    },
    "KeAk9Ks0": {
        "id": "KeAk9Ks0",
        "title": "Novel linear edge detector derived from Fresnel diffraction mode",
        "abstract": "This paper proposes an edge detection scheme based on Fresnel diffraction mode. Since Fresnel diffraction is mathematically complex, it is simplified into a linear convolution filter. Experiments on images are compared with the Laplacian of Gaussian, Sobel and Canny edge detection algorithms. The experimental results indicate that the new detector’s result is comparable to Canny detector and agree more with human’s recognition. And it also can get an even better edge map on some regions which contain abundant local details or some tiny changes.",
        "keywords": [
            "Canny detector",
            "Complex functions",
            "Convolution filter",
            "Edge detection",
            "Fresnel diffraction"
        ],
        "authors": [
            {
                "name": "DIAO Lu-Hong",
                "org": "Institute of Computing Technology Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Hua Li",
                "org": "Institute of Computing Technology Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Jisuanji Xuebao/Chinese Journal of Computers",
        "year": 2006
    },
    "glbxguO7": {
        "id": "glbxguO7",
        "title": "Fast stimulated emission nanoscopy based on single molecule localization",
        "abstract": "For super-resolution microscopy methods based on single molecule stochastic switching and localization, to simultaneously improve the spatial-temporal resolution, it is necessary to maximize the number of photons that can be collected from single molecules per unit time. Here, we describe a novel approach to enhance the signal intensity (collected photons per second) from fluorescence probes by introducing a stimulated emission (SE) optical process. This process is based on the following two properties: first, with reasonable parameters, the photon emission rate can be significantly increased with SE; and second, the SE photons, which are spatially coherent with the stimulation beam, are more favorable for collection than fluorescence. Theoretical results have shown that signal intensity from a single fluorescent molecule can be greatly improved with SE. We therefore showed, using SE in combination with single molecule localization methodology, that fast imaging at a rate of 0.05 s per reconstructed image with lateral resolutions of similar to 30 nm can be obtained. (C) 2015 Optical Society of America",
        "keywords": [
            "OPTICAL RECONSTRUCTION MICROSCOPY",
            "DETECTOR ARRAY",
            "FLUORESCENCE",
            "SPECTROSCOPY",
            "STORM",
            "LIMIT"
        ],
        "authors": [
            {
                "name": "Wang, Xuehua",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen, Danni",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu, Bin",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Niu, Hanben",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "APPLIED OPTICS",
        "year": 2015
    },
    "cc1qRyWJ": {
        "id": "cc1qRyWJ",
        "title": "Design and experimental demonstration of high-efficiency double-helix point spread function phase plate",
        "abstract": "Double helix point spread function possesses continuously rotating invariant features with defocus, and it can be used for performing nano-resolution image of thick samples and for studying singleparticle tracking by combining the single-molecule localization method. However, the inadequacy of the original double helix point spread function is that the transfer function efficiency is very low, so it is difficult to achieve photon limited applications for the bio-imaging. The double-helix point spread function is optimized by introducing an iterative algorithm so that the constraints of the point spread function can be optimized best in three different domains: the Laguerre-Gauss modal plane, the spatial domain, and the Fourier domain. The simulation results show that the peak intensity of high efficiency double helix point spread function is 30 times higher than the original one. The design and fabrication of the phase plate are also proposed. The experimental results are in good agreement with the theoretical predictions, thus proving the feasibility of this method.",
        "keywords": [
            "OPTICAL RECONSTRUCTION MICROSCOPY",
            "LOCALIZATION ACCURACY",
            "CELLS",
            "FIELDS"
        ],
        "authors": [
            {
                "name": "Li Heng",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Minist Educ &amp; Guangdong Prov, Key Lab Optoelect Devices &amp; Syst, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu Bin",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Minist Educ &amp; Guangdong Prov, Key Lab Optoelect Devices &amp; Syst, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen Dan-Ni",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Minist Educ &amp; Guangdong Prov, Key Lab Optoelect Devices &amp; Syst, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Niu Han-Ben",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Minist Educ &amp; Guangdong Prov, Key Lab Optoelect Devices &amp; Syst, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "ACTA PHYSICA SINICA",
        "year": 2013
    },
    "5i1u3COm": {
        "id": "5i1u3COm",
        "title": "Exploration of Phase Contrast Imaging Based on Zernike Phase Contrast Method",
        "abstract": "Traditional CT has a great limitation because its image is produced based on the X-ray absorbed by human tissue.Phase contrast imaging can get high-resolution and high-contrast images by using the change of phases to display the object.Then phase contrast imaging has been paid much attention to in recent years.However,phase-contrast images’ acquisition is very difficult now.In general,it needs to be resorted to third-generation synchrotron light sources.In order to break the limit of physics implementation and discuss the meaning of images phase information,a method to process medical images based on the Zernike phase-contrast method is presented.Experiments show that the produced images have the characteristics of phase contrast imaging.",
        "keywords": [
            "medical image processing",
            "computer application",
            "Zernike phase-contrast method",
            "phase contrast imaging"
        ],
        "authors": [
            {
                "name": "DIAO Lu-hong",
                "org": "Key Laboratory of Intelligent Information Processing,Institute of Computing Technology,Chinese Academy of Science,Beijing ,China;NCIC,Chinese Academy of Science,Beijing ,China;Graduate University,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "LI Hua",
                "org": "Key Laboratory of Intelligent Information Processing,Institute of Computing Technology,Chinese Academy of Science,Beijing ,China;NCIC,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Optoelectronic,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "PENG Xiang",
                "org": "Institute of Optoelectronic,Shenzhen University,Shenzhen Guangdong ,China"
            },
            {
                "name": "NIU Han-ben",
                "org": "Institute of Optoelectronic,Shenzhen University,Shenzhen Guangdong ,China"
            }
        ],
        "venue": "Journal of Engineering Graphics",
        "year": 2006
    },
    "Mf5g77T3": {
        "id": "Mf5g77T3",
        "title": "Improved localization accuracy in double-helix point spread function super-resolution fluorescence microscopy using selective-plane illumination",
        "abstract": "Recently, three-dimensional (3D) super resolution imaging of cellular structures in thick samples has been enabled with the wide-field super-resolution fluorescence microscopy based on double helix point spread function (DH-PSF). However, when the sample is Epi-illuminated, much background fluorescence from those excited molecules out-of-focus will reduce the signal-to-noise ratio (SNR) of the image in-focus. In this paper, we resort to a selective-plane illumination strategy, which has been used for tissue-level imaging and single molecule tracking, to eliminate out-of-focus background and to improve SNR and the localization accuracy of the standard DH-PSF super-resolution imaging in thick samples. We present a novel super-resolution microscopy that combine selective-plane illumination and DH-PSF. The setup utilizes a well-defined laser light sheet which theoretical thickness is 1.7 mu m (FWHM) at 640nm excitation wavelength. The image SNR of DH-PSF microscopy between selective-plane illumination and Epi-illumination are compared. As we expect, the SNR of the DH-PSF microscopy based selective-plane illumination is increased remarkably. So, 3D localization precision of DH-PSF would be improved significantly. We demonstrate its capabilities by studying 3D localizing of single fluorescent particles. These features will provide high thick samples compatibility for future biomedical applications.",
        "keywords": [
            "3-DIMENSIONAL TRACKING",
            "SINGLE",
            "RESOLUTION",
            "CELLS"
        ],
        "authors": [
            {
                "name": "jie yu",
                "org": "shenzhen university"
            },
            {
                "name": "bo cao",
                "org": "shenzhen university"
            },
            {
                "name": "h li",
                "org": "shenzhen university"
            },
            {
                "name": "bin yu",
                "org": "shenzhen university"
            },
            {
                "name": "danni chen",
                "org": "shenzhen university"
            },
            {
                "name": "hanben niu",
                "org": "shenzhen university"
            }
        ],
        "venue": "TWELFTH INTERNATIONAL CONFERENCE ON PHOTONICS AND IMAGING IN BIOLOGY AND MEDICINE (PIBM 2014)",
        "year": 2014
    },
    "uqNvdBDi": {
        "id": "uqNvdBDi",
        "title": "Design and analysis of new diffractive optic imaging spectrometer",
        "abstract": "To avoid the shortcoming of magnification change with wavelength, which will cause the spectral image pixel registration error and provide inaccurate relative spectral signal strength in the classical diffractive optic imaging spectrometer, a novel hybrid refraction/diffraction telecentric optical system combining a diffractive lens with an achromatic lens system is presented, and the working principle is then established. Furthermore, the concrete design example for visible/near-infrared imaging spectrometer is analyzed and evaluated with optical design software Zemax. The results prove the proposed method is valid and feasible. The shortcoming is overcome successfully, and the difficulty of the manufacturing process of the diffractive lens is also reduced. The theoretical and practical guidance is thereby provided for the study, design and engineering of the new diffractive optic imaging spectrometer with constant magnification.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Danni Chen",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "孙强 Sun Qiang",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Hanben Niu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Guangxue Xuebao/Acta Optica Sinica",
        "year": 2009
    },
    "KsVSIYiA": {
        "id": "KsVSIYiA",
        "title": "Design, fabrication, and experimental demonstration of a diffractive optical element with long depth of field for nanoscale three-dimensional multi-molecule tracking",
        "abstract": "The development of real-time single-molecule detection and tracking technology in time and space for multiple bio-molecules in intact cells has important significance for the study on molecular behaviors in life processes. However, limited depth of field is the main drawback of conventional microscopy that prevents observation and tracking of multiple molecules in intact cells. Based on the principle of wavefront coding, the design and fabrication of a novel diffractive optical element (DOE) which combines a distorted diffraction grating with a double-helix point spread function (PSF) phase plate so that it can simultaneously perform multi-plane imaging with double-helix PSF and realize an extended depth of field is presented. Experiments have been carried out on a self-built microscopic system based on the novel DOE, showing that a depth of field can be up to 12 mu m. Experimental results are in good agreement with the theoretical predictions, thus proving the feasibility of this method.",
        "keywords": [
            "PARTICLE TRACKING",
            "3 DIMENSIONS",
            "LIVE CELLS",
            "MICROSCOPY",
            "ACCURACY",
            "DYNAMICS"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Shenzhen Univ, Minist Educ, Key Lab Optoelect Devices &amp; Syst, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Li Heng",
                "org": "Shenzhen Univ, Minist Educ, Key Lab Optoelect Devices &amp; Syst, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen Dan-Ni",
                "org": "Tsinghua Univ, State Key Lab Precis Measurement Technol &amp; Instru, Beijing 100084, Peoples R China."
            },
            {
                "name": "Niu Han-Ben",
                "org": "Shenzhen Univ, Minist Educ, Key Lab Optoelect Devices &amp; Syst, Coll Optoelect Engn, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "ACTA PHYSICA SINICA",
        "year": 2013
    },
    "ws33995K": {
        "id": "ws33995K",
        "title": "Fast Fourier domain localization algorithm of a single molecule with nanometer precision.",
        "abstract": "We present an algorithm to determine the location of a fluorescent molecule with nanometer-scale accuracy. A Fourier domain localization scheme based on zero-padded fast Fourier transform and phase gradient operators is used to obtain a powerful mathematical model for localizing the molecule without numerical fitting. Compared with conventional algorithms, our position estimator does not require prior background information or initial parameter estimation. Numerical simulations indicate that the proposed method exhibits high localization precision and small bias while executing almost as fast as the fluoroBancroft algorithm.",
        "keywords": [
            "FLUORESCENT-PROBES",
            "MICROSCOPY",
            "TRACKING"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province, Institute of Optoelectronics, Shenzhen University, Shenzhen, China."
            },
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2011
    },
    "AQ1CEYvO": {
        "id": "AQ1CEYvO",
        "title": "Optical image encryption based on cascaded iterative angular spectrum algorithm and its implementation with parallel hardware",
        "abstract": "A cascaded iterative angular spectrum approach (CIASA) based on the methodology of virtual optics is presented for optical security applications. The technique encodes the target image into two different phase only masks (POM) using a concept of free-space angular spectrum propagation. The two phase-masks are designed and located in any two arbitrary planes interrelated through the free space propagation domain in order to implement the optical encryption or authenticity verification. And both phase masks can serve as enciphered texts. Compared with previous methods, the proposed algorithm employs an improved searching strategy: modifying the phase-distributions of both masks synchronously as well as enlarging the searching space. And with such a scheme, we make use of a high performance floating-point Digital Signal Processor (DSP) to accomplish a design of multiple-locks and multiple-keys optical image encryption system. An evaluation of the system performance is made and it is shown that the algorithm results in much faster convergence and better image quality for the recovered image. And two masks and system parameters can be used to design keys for image encryption, therefore the decrypted image can be obtained only when all these keys are under authorization. This key-assignment strategy may reduce the risk of being intruded and show a high security level. These characters may introduce a high level security that makes the encrypted image more difficult to be decrypted by an unauthorized person.",
        "keywords": [
            "INFORMATION ENCRYPTION",
            "SECURITY",
            "SYSTEM",
            "CORRELATOR",
            "DOMAIN"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xiang Peng",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Jindong Tian",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Hanben Niu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2006
    },
    "iIDqaWEh": {
        "id": "iIDqaWEh",
        "title": "Fast Fourier domain localization algorithm of a single molecule with nanometer precision",
        "abstract": "",
        "keywords": [
            "fluorescence microscopy",
            "superresolution",
            "image analysis"
        ],
        "authors": [
            {
                "name": "danni chen",
                "org": "shenzhen university"
            },
            {
                "name": "junle qu",
                "org": "shenzhen university"
            },
            {
                "name": "bin yu",
                "org": "shenzhen university"
            },
            {
                "name": "hanben niu",
                "org": "shenzhen university"
            }
        ],
        "venue": "Optics Letters",
        "year": 2011
    },
    "We330pxo": {
        "id": "We330pxo",
        "title": "Multiresolution 3D imaging with temporal sequential fringe projector",
        "abstract": "In order to implement 3-D imaging of objects with large height discontinuities and/or surface isolation, we present a novel 3-D imaging system based on temporal sequential fringe projector to provide multi-resolution 3-D reconstruction. To recover the range data of such a surface, en enhanced scheme for temporal phase unwrapping procedure is proposed. We also describe methods for extracting the color texture corresponding to a range image. Experimental results are given to illustrate the validity of our proposed method.",
        "keywords": [
            "digital projector",
            "time-varying fringe patterns",
            "multi-resolution",
            "temporal phase unwrapping",
            "texture mapping"
        ],
        "authors": [
            {
                "name": "jindong tian",
                "org": "shenzhen university"
            },
            {
                "name": "xiang peng",
                "org": "shenzhen university"
            },
            {
                "name": "bin yu",
                "org": "shenzhen university"
            },
            {
                "name": "bin wu",
                "org": "shenzhen university"
            },
            {
                "name": "peng zhang",
                "org": "tianjin university"
            },
            {
                "name": "linbin wei",
                "org": "tianjin university"
            },
            {
                "name": "wenjie qiu",
                "org": "tianjin university"
            }
        ],
        "venue": "PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)",
        "year": 2005
    },
    "W2KvcvVJ": {
        "id": "W2KvcvVJ",
        "title": "Synthesis and nonlinear optical properties of single-crystalline KNb 3 O 8 nanowires",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hanben niu",
                "org": ""
            },
            {
                "name": "huiqun cao",
                "org": ""
            },
            {
                "name": "xinpeng zhang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "bo cao",
                "org": ""
            },
            {
                "name": "junle qu",
                "org": ""
            },
            {
                "name": "danni chen",
                "org": ""
            }
        ],
        "venue": "Nanotechnology",
        "year": 2013
    },
    "axKv2LEB": {
        "id": "axKv2LEB",
        "title": "Simulation study of phase retrieval for hard X-ray in-line phase contrast imaging",
        "abstract": "Two algorithms for the phase retrieval of hard X-ray in-line phase contrast imaging are presented. One is referred to as lterative\n Angular Spectrum Algorithm (IASA) and the other is a hybrid algorithm that combines IASA with TIE (transport of intensity\n equation). The calculations of the algorithms are based on free space propagation of the angular spectrum. The new approaches\n are demonstrated with numerical simulations. Comparisons with other phase retrieval algorithms are also performed. It is shown\n that the phase retrieval method combining the IASA and TIE is a promising technique for the application of hard X-ray phase\n contrast imaging.",
        "keywords": [
            "FRESNEL REGION",
            "ALGORITHMS"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Shenzhen University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, Institute of Optoelectronics 518060 Shenzhen China"
            },
            {
                "name": "Xiang Peng",
                "org": "Shenzhen University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, Institute of Optoelectronics 518060 Shenzhen China"
            },
            {
                "name": "Jindong Tian",
                "org": "Shenzhen University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, Institute of Optoelectronics 518060 Shenzhen China"
            },
            {
                "name": "Hanben Niu",
                "org": "Shenzhen University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education, Institute of Optoelectronics 518060 Shenzhen China"
            },
            {
                "name": "Luhong Diao",
                "org": "Chinese Academy of Sciences Key Laboratory of Intelligent Information Processing, Institute of Computing Technology 100080 Beijing China"
            },
            {
                "name": "Hua Li",
                "org": "Chinese Academy of Sciences Key Laboratory of Intelligent Information Processing, Institute of Computing Technology 100080 Beijing China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2005
    },
    "ZblCcb83": {
        "id": "ZblCcb83",
        "title": "Nanoscale three-dimensional single particle tracking by light-sheet-based double-helix point spread function microscopy",
        "abstract": "The double-helix point spread function (DH-PSF) microscopy has become an essential tool for nanoscale three-dimensional (3D) localization and tracking of single molecules in living cells. However, its localization precision is limited by fluorescent contrast in thick samples because the signal-to-noise ratio of the system is low due to the inherent low transfer function efficiency and background fluorescence. Here we combine DH-PSF microscopy with light-sheet illumination to eliminate out-of-focus background fluorescence for high-precision 3D single particle tracking. To demonstrate the capability of the method, we obtain the single fluorescent bead image with light-sheet illumination, with three-dimensional localization accuracy better than that of epi-illumination. We also show that the single fluorescent beads in agarose solution can be tracked, which demonstrates the possibility of our method for the study of dynamic processes in complex biological specimens. (C) 2016 Optical Society of America",
        "keywords": [
            "PLANE ILLUMINATION MICROSCOPY",
            "FLUORESCENCE MICROSCOPY",
            "LOCALIZATION ACCURACY",
            "RESOLUTION",
            "DIMENSIONS",
            "MOLECULES",
            "CELLS"
        ],
        "authors": [
            {
                "name": "Yu, Bin",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu, Jie",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Li, Weihai",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Cao, Bo",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Li, Heng",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen, Danni",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Niu, Hanben",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Shenzhen Key Lab Micronano Measuring &amp; Imaging Bi, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "APPLIED OPTICS",
        "year": 2016
    },
    "HkHgtcbp": {
        "id": "HkHgtcbp",
        "title": "Phase retrieval for in-line hard x-ray phase-contrast imaging with the Yang-Gu algorithm",
        "abstract": "X-ray phase-contrast imaging is an important diagnostic tool in medicine, biology and materials science. In-line hard x-ray phase-contrast imaging is based on Fresnel diffraction of x-ray, therefore we propose to make phase retrieval calculations between arbitrary planes interrelated through the Fresnel domain. A new approach to the numerical reconstruction of object phase by the diffraction intensity for in-line x-ray phase-contrast imaging is presented. The new method is tested on simulated image and the results demonstrate the validity of this new approach.",
        "keywords": [
            "hard x-ray",
            "imaging",
            "phase retrieval",
            "phase-contrast imaging",
            "x-ray phase-contrast",
            "medicine",
            "diffraction",
            "materials science",
            "phase contrast",
            "biology"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xiang Peng",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Jindong Tian",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Hanben Niu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2006
    },
    "SdXd4YaN": {
        "id": "SdXd4YaN",
        "title": "A new edge detector based on Fresnel diffraction",
        "abstract": "This paper proposed an edge detection scheme which is deduced from Fresnel diffraction. Analysis in this paper shows that Fresnel convolution kernel function performs well on edge enhancement when images are transformed into complex functions. Due to its mathematical complexity, the method is simplified into a linear convolution filter. The new edge detector is designed based on the simplified linear filter. Experimental results indicate that the new detector gives quantitative results equal to the Canny detector while it is more simple to be implemented.",
        "keywords": [
            "STATISTICAL APPROACH",
            "ALGORITHMS"
        ],
        "authors": [
            {
                "name": "Luhong Diao",
                "org": "Key Lab of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China and Graduate University, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Bin Yu",
                "org": "Institute of Optoelectronics, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Hua Li",
                "org": "Key Lab of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China"
            }
        ],
        "venue": "Pattern Recognition Letters",
        "year": 2007
    },
    "OPzq3RBy": {
        "id": "OPzq3RBy",
        "title": "A real-time axial activeanti-drift device with high-precision",
        "abstract": "In a fluorescent nano-resolution microscope based on single molecular localization, drift of focal plane will bring an additional deviation to the accuracy of single molecular localization. Consequently, this will reduce the final resolution of the reconstructed image and cause image degradation. Therefore, it is vital to control the system drift to a minimum level as much as possible. In recent years, the anti-drift ways emerged in endlessly. In this paper we made a systematic study aiming at the method in which optical measurement and negative feedback control are used. The basic principle and its implementation of the system are analyzed, and possible error is also evaluated. Finally, the precision of the system is tested experimentally. With this device, axial drift can be detected and corrected automatically in time, and the axial anti-drift accuracy as high as 9.93 nm can be achieved, which is one order higher than that of the existing commercial microscopies.",
        "keywords": [
            "PHOTOACTIVATION LOCALIZATION MICROSCOPY",
            "OPTICAL RECONSTRUCTION MICROSCOPY",
            "DIFFRACTION-LIMIT",
            "FLUORESCENCE",
            "NM"
        ],
        "authors": [
            {
                "name": "Huo Ying-Dong",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Cao Bo",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Yu Bin",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen 518060, Peoples R China."
            },
            {
                "name": "Chen Dan-Ni",
                "org": "Tsinghua Univ, State Key Lab Precis Measurement Technol &amp; Instru, Beijing 100084, Peoples R China."
            },
            {
                "name": "Niu Han-Ben",
                "org": "Shenzhen Univ, Coll Optoelect Engn, Key Lab Optoelect Devices &amp; Syst, Minist Educ &amp; Guangdong Prov, Shenzhen 518060, Peoples R China."
            }
        ],
        "venue": "ACTA PHYSICA SINICA",
        "year": 2015
    },
    "bQ8FqOYK": {
        "id": "bQ8FqOYK",
        "title": "Synthesis and nonlinear optical properties of single-crystalline KNb3O8 nanowires.",
        "abstract": "Single-crystalline KNb(3)O(8) nanowires with widths of 100-300 nm and lengths up to tens of microns were synthesized by calcining Nb(2)O(5) powders in molten KCl and K(2)SO(4). The phase of the products was determined by means of x-ray diffraction, and the morphology and structure were characterized by using scanning electron microscopy, transmission electron microscopy, high resolution transmission electron microscopy and selected area electron diffraction techniques. The growth direction of the KNb(3)O(8) obtained was determined to be the [001] crystallographic direction. Meanwhile, the polarization response of the second-harmonic generation (SHG) response was investigated. The as-synthesized nanowires clearly exhibited a SHG response, which means that the nanowires were an efficient nanoscale second-harmonic light source. The excellent nonlinear optical property of KNb(3)O(8) shows potential for application in nano-optical devices.",
        "keywords": [
            "HYDROTHERMAL SYNTHESIS",
            "NIOBIUM OXIDE",
            "NIOBATE",
            "POWDERS"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of the Ministry of Education and Guangdong Province, Shenzhen University, Shenzhen 518060, People's Republic of China."
            },
            {
                "name": "Bo Cao",
                "org": ""
            },
            {
                "name": "Huiqun Cao",
                "org": ""
            },
            {
                "name": "Xinpeng Zhang",
                "org": ""
            },
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            }
        ],
        "venue": "Nanotechnology",
        "year": 2013
    },
    "atePaCqy": {
        "id": "atePaCqy",
        "title": "Hydrothermal Synthesis of KNbO_3",
        "abstract": "The potassium niobate were prepared with niobium pentoxide and potassium hydroxide as source materials by hydrothermal synthesis method. The product was characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). We also studied the effect of the concentration of potassium hydroxide solution and hydrothermal temperature on the component and morphology. The pure KNbO3 crystal could be prepared when it was synthesized at 220 oC and the concentration of potassium hydroxide solution was 10 mol/L. The as-synthesized crystal shows sheet shape with the size of 0.5-1.5 μm. When the concentration of potassium hydroxide solution was kept at 10 mol/L and the temperature was decreased to 180 oC, the product was still pure KNbO3 crystal with sheet shape and the size became 0.5-1 μm and some crystals also showed long and narrow morphology. The pure KNbO3 powder could be obtained at 180 oC when the concentration of potassium hydroxide solution was 6 mol/L, and the size of crystal was 0.4-1 μm. Some KNbO3 assemble the club-shaped crystal with the length of 10 μm. FTIR results indicate that the crystal showed Nb=O and Nb-O-Nb vibration peak. The reactive temperatures have no influence on the positions of the Nb=O and Nb-O-Nb peaks.",
        "keywords": [
            "potassium niobate",
            "hydrothrmal synthesis"
        ],
        "authors": [
            {
                "name": "Cao Huiqun",
                "org": "Shenzhen University, Shenzhen , China"
            },
            {
                "name": "Wang Fang",
                "org": "Shenzhen University, Shenzhen , China"
            },
            {
                "name": "Yu Bin",
                "org": "Shenzhen University, Shenzhen , China"
            },
            {
                "name": "Wang Yinzhi",
                "org": "Shenzhen University, Shenzhen , China"
            },
            {
                "name": "Li Shangjiao",
                "org": "Shenzhen University, Shenzhen , China"
            },
            {
                "name": "Luo Zhongkuan",
                "org": "Shenzhen University, Shenzhen , China"
            }
        ],
        "venue": "Rare Metal Materials and Engineering",
        "year": 2010
    },
    "4JcFsEo0": {
        "id": "4JcFsEo0",
        "title": "Study on the controlling method of exhaust gas diffusion from a tunnel portal",
        "abstract": "A three-dimensional numerical simulation is used in this paper to predict the exhaust gas diffusion from a tunnel portal in different wind direction,and a pollution controlling method which is much more economical is also proposed in this paper.",
        "keywords": [
            "Density field",
            "Exhaust gas diffusion",
            "Tunnel portal"
        ],
        "authors": [
            {
                "name": "KUANG Jiang-hong",
                "org": "School of Mechanical Engineering,Shanghai University of Engineering Science,Shanghai ,China"
            },
            {
                "name": "ZHU Guo-qing",
                "org": "Shanghai Marine Diesel Engine Research Institute,Shanghai ,China"
            },
            {
                "name": "YU Bin",
                "org": "Shanghai Urban Construction Design & Research Institute,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Computational Mechanics",
        "year": 2005
    },
    "Niy4jGV7": {
        "id": "Niy4jGV7",
        "title": "A Study of Fire Protection System of Large Atrium Subway Station",
        "abstract": "The large atrium subway station is defined and classified in the paper. A new type smoke control system different from the routine subway station is put forward by introducing the fire protection system of Huamu Rd. Station of Shanghai Metro Line 7. The fire proofing and smoke extracting system, evacuation facilities are simulated and analyzed by using performance analysis method. The results show that smoke spread can be effectively controlled for the evacuation to provide \"acceptable sustain life environment\" by using the smoke exhausting control duct under the roof of large atrium, in case of fire.",
        "keywords": [
            "performance analysis",
            "large atrium metro station",
            "smoke control system",
            "fire protection system"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Shanghai Urban Construction Design & Research Institute, Shanghai , China"
            }
        ],
        "venue": "China Municipal Engineering",
        "year": 2010
    },
    "o3HQfUmH": {
        "id": "o3HQfUmH",
        "title": "The Influence of Glass Envelope on Air Conditioning Cold Load in Subway Station",
        "abstract": "According to the difference of air conditioning cold load between civilian construction and subway station,this paper discusses the analytic method of hourly cold load calculation for the underground railway station which is installed with skylight,and the ordinary outer envelope on top slab combined with varied outdoor design temperatures.Then this paper analyses the influence of the skylight area ratio,the passenger flux on air conditioning cold load and the equipment capacity of the standard public zone of station,obtains a proper ratio which needs no increase of the equipment capacity.Additionally,it analyses the practical use of glass envelope at Longde Road Station of Shanghai Urban Rail Transit Line 11,argues that the obtained parameters can provide reference for similar design works.",
        "keywords": [
            "air conditioning cold load",
            "skylight",
            "glass envelope",
            "subway station"
        ],
        "authors": [
            {
                "name": "Huang Lijun",
                "org": " Shanghai Urban Construction Design & Research Institute,,Shanghai,China"
            },
            {
                "name": "Yu Bin",
                "org": " Shanghai Urban Construction Design & Research Institute,,Shanghai,China"
            },
            {
                "name": "Wang Yuchuan",
                "org": " Shanghai Urban Construction Design & Research Institute,,Shanghai,China"
            }
        ],
        "venue": "Urban Mass Transit",
        "year": 2009
    },
    "Fw4nIqhW": {
        "id": "Fw4nIqhW",
        "title": "Design and Analysis on Fire Prevention of Xujiahui Subway Station Transferring Hall",
        "abstract": "Based on the rule of a suitable environment for evacuation and evacuating time,the functional fire safety method was adopted,in which,the most unfavorable condition was taken into account,different fire scenes were built up for the simulation and analysis of the fire prevention and smoke extraction system,personnel evacuating facilities of Xujiahui subway station transferring hall.The result proves that the fire prevention system is safe and reliable.",
        "keywords": [
            "transferring hall",
            "subway station",
            "fire prevention analysis"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Shanghai Urban Construction Design & Research Institute,Shanghai ,China"
            },
            {
                "name": "XU Zheng-liang",
                "org": "Shanghai Urban Construction Design & Research Institute,Shanghai ,China"
            },
            {
                "name": "LI Jin-xiong",
                "org": "Parsons Brinckerhoff%%#Asia%%# Ltd.,Hong Kong ,China"
            }
        ],
        "venue": "Journal of Shanghai University of Engineering Science",
        "year": 2010
    },
    "hzA4szia": {
        "id": "hzA4szia",
        "title": "Ventilation and Air Conditioning Design of an Underground Metro Station Concourse",
        "abstract": "This paper introduces the ventilation, air conditioning and smoke control design essentials of the first underground urban rail transit station with concourse in Shanghai-Longyang Road Station on Line 7. It analyzes the system in terms of smoke control partitioning, layout of air ducts and system operation etc. Furthermore, it indicates the major differences in terms of the ventilation and air conditioning design between a station with concourse and typical stations.",
        "keywords": [
            "Longyang Road Station",
            "station with concourse",
            "smoke control",
            "smoke control partitioning"
        ],
        "authors": [
            {
                "name": "Huang Lijun",
                "org": "Shanghai Urban Construction Design & Research Institute, Shanghai "
            },
            {
                "name": "Yu Bin",
                "org": "Shanghai Urban Construction Design & Research Institute, Shanghai "
            },
            {
                "name": "Chen Haiying",
                "org": "Shanghai Urban Construction Design & Research Institute, Shanghai "
            },
            {
                "name": "Li Jinxiong",
                "org": " Parsons Brinckerhoff %%#Asia%%# Ltd., Hong Kong"
            },
            {
                "name": "Wang Jinghong",
                "org": " Parsons Brinckerhoff %%#Asia%%# Ltd., Hong Kong"
            }
        ],
        "venue": "Urban Rapid Rail Transit",
        "year": 2006
    },
    "Cpqi7m6p": {
        "id": "Cpqi7m6p",
        "title": "Verifiable Visual Cryptography Based on Iterative Algorithm",
        "abstract": "By changing sharing and recovering ways of the verification image,a verifiable Visual Cryptography Scheme(VCS) based on iterative algorithm is proposed in this paper.Since the verification image is shared with special algorithms,and the verification process is optimized through iterative algorithm,the proposed scheme not only makes the pixel expansion much smaller,but also improves the checking efficiency greatly.Furthermore,verification images are perfectly recovered by the XOR operation introduced.",
        "keywords": [
            "Verifiable",
            "Pixel expansion",
            "Cheating prevention",
            "Visual cryptography"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "Lu Jin-yuan",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "Fang Li-guo",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2011
    },
    "8JjKjp2y": {
        "id": "8JjKjp2y",
        "title": "Design and simulation of one user authentication scheme in bluetooth",
        "abstract": "Based on the analysis of existing security mechanism in bluetooth,an implementation scheme of bluetooth user authentication is proposed due to the fact that user can not be recognized.A user authentication protocol is designed and improved,and then S-ECSRP protocol is put forward.The simulation result shows that the scheme is practical.It also implies that the S-ECSRP protocol is feasible and effective.",
        "keywords": [
            "protocol",
            "bluetooth",
            "SRP",
            "security",
            "simulation",
            "user authentication"
        ],
        "authors": [
            {
                "name": "WANG Li-tao",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2008
    },
    "YzTerHIU": {
        "id": "YzTerHIU",
        "title": "Design and implementation of Bluetooth host based on NiosII",
        "abstract": "Based on NiosII CPU core and some associative peripheral equipment,a Bluetooth host is designed and built in FPGA with SOPC.The results running under quartus II and NiosII IDE show that the host designed can fully meet data transmission requirement of Bluetooth specification V2.0.Also it’s more flexible,lower in price and occupies fewer resources compared with other general Bluetooth hosts.",
        "keywords": [
            "control",
            "Bluetooth host",
            "HCI",
            "switch between states",
            "NiosII soft-core"
        ],
        "authors": [
            {
                "name": "LI Hai-yan",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2009
    },
    "Qbh1IRap": {
        "id": "Qbh1IRap",
        "title": "Design and implementation of access control scheme in Bluetooth",
        "abstract": "By controlling procedure for establishing connection in L2CAP and RFCOMM and packet in receiving flow in HCI,L2CAP and RFCOMM,an access control scheme in them for Bluetooth is presented and is implemented based on BlueZ protocol stack.Experi-mental results demonstrate this scheme can control without delay,solve the problem that it has control with delay for access control scheme in Bluetooth and ensure security for accessing.",
        "keywords": [
            "L2CAP",
            "access control",
            "Bluetooth",
            "RFCOMM",
            "HCI",
            "security"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "LU Xiao-liang",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2009
    },
    "zsETRv99": {
        "id": "zsETRv99",
        "title": "Implementation of complex computing cryptography algorithm based on Bluetooth chip",
        "abstract": "Through analysis on the internal structure and the working characteristic of Bluetooth chip,a parallel cryptography algorithm instruction structure model based on Digtal Signal Processor(DSP) coprocessor and the algorithm working procedure was designed.The model was designed by considering two aspects of time overhead and storage space.And the model implemented the high computational and complex cryptography algorithm with DSP coprocessor possible during the Bluetooth communication.The experimental results show that the method can reduce the influence of complex cryptography to Bluetooth transmission.",
        "keywords": [
            "Bluetooth chip",
            "cryptography algorithm",
            "Bluetooth security",
            "Digtal Signal Processor(DSP) coprocessor"
        ],
        "authors": [
            {
                "name": "HUANG Yi-cai",
                "org": "Information Engineering University,Zhengzhou Henan ,China"
            },
            {
                "name": "YU Bin",
                "org": "Information Engineering University,Zhengzhou Henan ,China"
            }
        ],
        "venue": "Journal of Computer Applications",
        "year": 2012
    },
    "1aB4Fguu": {
        "id": "1aB4Fguu",
        "title": "USB Device Driver for Linux Bluetooth Stack",
        "abstract": "This paper depicts the structure and characteristics of BlueZ based on analyzing the source code of Linux bluetooth stack BlueZ.It analyzes the implementation of bluetooth USB transport driver scheme and data processing procedure in detail,and gives the key data structure and implementation of bluetooth device driver.It summarizes the approach of developing Linux bluetooth USB device driver and the key technology.",
        "keywords": [
            "device driver",
            "Linux system",
            "bluetooth stack"
        ],
        "authors": [
            {
                "name": "LIANG Jun-xue",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2008
    },
    "sTDTActa": {
        "id": "sTDTActa",
        "title": "A New Multi-Secret Sharing Visual Cryptography",
        "abstract": "A definition of multi-secret sharing visual cryptography has been proposed,which supports multiple qualified sets and shares operations.Based on the area marking and the basis matrices of single secret sharing visual cryptography,the procedures of multi-secret sharing and recovering are designed.Furthermore,a scheme is realized.At last,the effectiveness is proved and verified by experiments.",
        "keywords": [
            "multi-secret sharing",
            "visual cryptography",
            "area marking"
        ],
        "authors": [
            {
                "name": "FU Zheng-xin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou,Henan ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou,Henan ,China"
            },
            {
                "name": "FANG Li-guo",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou,Henan ,China"
            }
        ],
        "venue": "Acta Electronica Sinica",
        "year": 2011
    },
    "s5Cng1kb": {
        "id": "s5Cng1kb",
        "title": "Implementation of Parameters Selectable Elliptic Curve Cryptosystem Based on Binary Fields",
        "abstract": "The implementation of ECC is difficult,and it often needs special chips to speed the algorithms.An implementation of parameters selectable ECC based on FPGA was discussed after researching the key algorithms.It offers some method to speed the algorithms implementation.Through the design,it shows the scheme is adaptive to hardware implementation.",
        "keywords": [
            "finite field",
            "ECC",
            "encryption"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou Henan ,China"
            },
            {
                "name": "CAI Zhen-guo",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou Henan ,China"
            },
            {
                "name": "CHEN Tao",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou Henan ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2007
    },
    "6odiTU8F": {
        "id": "6odiTU8F",
        "title": "DESIGN OF SECURE KEY TRANSPORT STREAM BASED ON MPEG-2",
        "abstract": "Secure keys transmission is the precondition of system security in secrecy communication system.Based on the research on MPEG-2 standard,a way of re-key which can be used in DTTB system is proposed,and a key transport stream for transporting the keys is designed.Security and error detection mechanism is added before the sending of KTS.The simulated results verify that KTS has good security and integrality,and it is suitable for digital TV wireless secrecy communication system.",
        "keywords": [
            "DTTB system MPEG-2 standard Re-key Key transmission"
        ],
        "authors": [
            {
                "name": "Gao Xin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,Henan,China"
            },
            {
                "name": "Yu Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,Henan,China"
            }
        ],
        "venue": "Computer Applications and Software",
        "year": 2007
    },
    "r6QmmxkA": {
        "id": "r6QmmxkA",
        "title": "Design and research of embedded USB-host based on NiosII",
        "abstract": "A design method of embedded USB-host is proposed based on SoPC,the data is transferred from point to another by SL811HS,which is controlled by NiosII CPU embedded into FPGA.A detail design scheme is mentioned and a single application to USB-host on information security is presented in detail,experiments show the practicality and efficiency.",
        "keywords": [
            "USB-host",
            "SoPC",
            "NiosII CPU",
            "embedded host",
            "SoC"
        ],
        "authors": [
            {
                "name": "LIU Lian-dong",
                "org": "College of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "LUO Chang-yuan",
                "org": "College of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2007
    },
    "gzOhOMMz": {
        "id": "gzOhOMMz",
        "title": "Method of mutual information filtration with dual-threshold for term extraction",
        "abstract": "In order to reduce the impact of problems inherent in the mutual information method on the filtering effect,a method of candidate term filtration and extraction was proposed.And a determination algorithm based on partial evaluating indicator was given,which can give the best upper and lower thresholds fast and accurately through data sampling,statistics and computation.Compared with the method of mutual information filtration with single threshold,the proposed method filtered and extracted candidate terms by setting two thresholds in the premise of not changing the calculating formula of mutual information.The experimental results show that the proposed method can improve the precision rate and F-measurement significantly under the same conditions.",
        "keywords": [
            "evaluating indicator",
            "mutual information",
            "term extraction",
            "term filtration",
            "threshold"
        ],
        "authors": [
            {
                "name": "CHEN Shi-chao",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou Henan ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou Henan ,China"
            }
        ],
        "venue": "Journal of Computer Applications",
        "year": 2011
    },
    "LD5gmH2Q": {
        "id": "LD5gmH2Q",
        "title": "( k,n) Multi-secret Visual Cryptography Based on XOR",
        "abstract": "To solve the problem that the pixel expansion enlarges and contrast decreases rapidly along with increasing the secret images and participants w hen multiple participants share multiple secret images,starting w ith the algebraic structure,this paper gives a definition of the multi-secret visual cryptography scheme w ith the operation XOR and cylinder share rotation,w hich supports sharing multiple secrets in the(k,n) threshold structure.Regarding the basis matrices of XOR-based single secret sharing visual cryptography as the encryption unit,the procedures of multi-secret sharing and recovering are designed,furthermore,a scheme is realized.The experimental results show that the proposed scheme not only encrypts multiple secrets w ithin multiple shares,but also improves the pixel expansion and the relative difference.",
        "keywords": [
            "multi-secret",
            "XOR",
            "cylinder shares",
            "visual cryptography"
        ],
        "authors": [
            {
                "name": "SHEN Gang",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            }
        ],
        "venue": "Journal of Chinese Computer Systems",
        "year": 2013
    },
    "B14i1czj": {
        "id": "B14i1czj",
        "title": "Multilevel security scheme of removable storage device",
        "abstract": "To solve the problem of information leakage while removable storage devices being used among PCs with different secure,a scheme of multilevel security of removable storage device based on file system filter driver is proposed.On the basis of special hardware structure of removable storage device,access control mechanism is added to file operations through the file system filter deriver,and made the access of PC to removable storage device under control.Experimental results demonstrate that this scheme realize the fine grain control of file operations and encryption of document storage,protecting the security while removable storage device using among PCs with different security level effectively.",
        "keywords": [
            "encrypted storage",
            "key management",
            "file system filter driver",
            "multilevel",
            "removable storage device"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2011
    },
    "TTZIc3HU": {
        "id": "TTZIc3HU",
        "title": "Shortest path search algorithm based on MapX",
        "abstract": "After the analysis of the shortest path search and special character,a new algorithm based on the MapX of part of the shortest path search is proposed,the algorithm search in a small rectangle based on the character that the shortest path is near the line which one point is the start point and the other is end point,it solved the fuzzy problem that made by surge,reduced the search the number of point and scale.A test showed that this algorithm run more fast,and more efficient in the complex road network,and it’s practicable.",
        "keywords": [
            "rectangle",
            "surge",
            "shortest path",
            "part search",
            "algorithm"
        ],
        "authors": [
            {
                "name": "LI Xiao-peng",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "LI Ya-min",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2009
    },
    "ief0p9iA": {
        "id": "ief0p9iA",
        "title": "Operation-based Multi-secret Visual Cryptography Scheme with Disguised Patterns",
        "abstract": "The ring shares were divided into the disguised area and the tagged secret areas.Combining with the basic matrices of(2,2) single secret visual cryptography,an operation-based multi-secret visual cryptography scheme with disguised images was designed.The proposed scheme not only makes the number of secret images boundless,but also improves the pixel expansion and the relative difference of previous schemes.Furthermore,the meaningful disguised patterns can reduce the attackers' threats to shares.",
        "keywords": [
            "Ring share",
            "Multi-secret sharing",
            "Visual cryptography",
            "Disguised patterns"
        ],
        "authors": [
            {
                "name": "FU Zheng-xin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "FANG Li-guo",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Science",
        "year": 2011
    },
    "H5qGOd5X": {
        "id": "H5qGOd5X",
        "title": "XOR visual cryptography based on optimization model",
        "abstract": "By constructing the optimization model for visual cryptography based on group structure,designed a XOR-based threshold scheme.In this scheme,translated the problem of basic matrix construction to evaluation of probability,and generated the shares by choosing encryption rule with probability-matrix.The scheme not only improves the contrast greatly,but also has no pixel expansion.",
        "keywords": [
            "no pixel expansion",
            "XOR",
            "visual cryptography",
            "optimization"
        ],
        "authors": [
            {
                "name": "SHI Lin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "WANG Yi-wei",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2011
    },
    "7wJ6efar": {
        "id": "7wJ6efar",
        "title": "Verifiable visual cryptography based on group structure",
        "abstract": "Aiming at improving the bad recovery effects of previous verifiable visual cryptography schemes(VCS),a new verifiable VCS based on group structure is proposed in this paper.This scheme eliminates pixel expansion by modifying the way of secret sharing,and makes the verification image recover with no distortion by importing XOR operation,which has an algebraic structure of group,to the verification process.",
        "keywords": [
            "secret sharing",
            "group structure",
            "visual cryptography"
        ],
        "authors": [
            {
                "name": "LU Jin-yuan",
                "org": "School of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Hefei University of Technology(Natural Science)",
        "year": 2011
    },
    "UwUC6fU7": {
        "id": "UwUC6fU7",
        "title": "Pixel Unexpanded MSM Visual Cryptography Scheme",
        "abstract": "Based on characteristic that the human visual system averages over close pixels' gray levels,through preprocessing of region segmentation and multi-line scan in mark-sharing process,a multi-line scan based pixel unexpanded MSM visual cryptography scheme has been proposed.The scheme has resolved out the problems not only that the boundary between neighboring regions is dim,but also that granularity is much larger,and has increased efficiency.Experimental results demonstrate that the time for sharing is much less,and the recovered image has much better visual effect.",
        "keywords": [
            "secret sharing",
            "multi-line scan",
            "mark-sha-ring",
            "pixel unexpanded",
            "visual cryptography"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "WANG Cui",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Information Engineering University",
        "year": 2007
    },
    "lEmHCrYE": {
        "id": "lEmHCrYE",
        "title": "Modeling and security protection on electromagnetic compromising emanations of information technology equipment",
        "abstract": "The electromagnetic compromising emanations of information technology equipment and its protection are researched with the help of modeling.Electromagnetic interference and electromagnetic compromising emanations are comparatively analyzed.And it is found that electromagnetic interference emphasized the consequence of electromagnetic energy transfer,while electromagnetic compromising emanations pay more attention to the unintentional information leakage via electromagnetic waves.Modeling of electromagnetic compromising emanations is done with reference to the communication system.The concept of channel capacity is introduced and the conditions that should be met for information eavesdropping and recovery are given.On this basis,the security protection of electromagnetic compromising emanations is studied from the aspects of source and path.Research conclusions can give directions to the security protection and provide comprehensive insurance to information security.",
        "keywords": [
            "electromagnetic compromising emanations",
            "security protection",
            "modeling",
            "communication system",
            "information security"
        ],
        "authors": [
            {
                "name": "WANG Li-tao",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2013
    },
    "w2fRIiIK": {
        "id": "w2fRIiIK",
        "title": "The Access-based Multi-secret Visual Cryptography with Compression Algorithm",
        "abstract": "According to the mapping relationship between the multiple secret images’ pixel combinations and the basis matrices,the redundant basis matrices are analyzed in the access-based multi-secret visual cryptography.A compression algorithm is proposed to decrease the size of basis matrices.The algorithm takes one column pixels as disposal unit,and satisfies the entire contrast of secret images.Based on the algorithm,new secret sharing and recovering procedures are designed for the access-based multi-secret visual cryptography.Compared with previous schemes,the present scheme can diminish the size of shares effectively,and the compression effects are obvious for the simple images.",
        "keywords": [
            "Redundant basis matrices",
            "Multiple secrets",
            "Access-based",
            "Visual cryptography",
            "Compression algorithm"
        ],
        "authors": [
            {
                "name": "Fu Zheng-xin",
                "org": "Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "Yu Bin",
                "org": "Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "Fang Li-guo",
                "org": "Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2013
    },
    "lDKxaoGC": {
        "id": "lDKxaoGC",
        "title": "(2,n) Visual Threshold Scheme Based on Permutation",
        "abstract": "Two parameters,pixel expansion and contrast,are very important in visual cryptography.It's very difficult to optimize both of them in theory.Based on permutation,a(2,n)scheme,which existence has been proved theoretically,is proposed.The method of construction has been carried out.Simulation results demonstrate that this scheme can balance performance between pixel expansion and contrast,i.e.,when the contrast is close to optimality,the pixel expansion is relatively minor.",
        "keywords": [
            "Visual cryptography",
            "Permutation",
            "Visual secret sharing scheme",
            "Visual threshold scheme(VTS)"
        ],
        "authors": [
            {
                "name": "FANG Liguo",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2007
    },
    "NsKq5DkC": {
        "id": "NsKq5DkC",
        "title": "XOR-Based Ideal Threshold Visual Cryptography Scheme",
        "abstract": "Participants in the ideal recovery visual cryptography scheme(VCS) need to store multiple shares.To solve this problem,this paper propses the concept of shares marshalling function and an algorithm of shares combination and extraction,with a(k,n) VCS constructed.This VCS can recover secrets images perfectly while keep every participant storing one single share.Experiments indicate this scheme can improve recovery efficiency and simplify shares management.",
        "keywords": [
            "XOR",
            "visual cryptography",
            "threshold scheme",
            "ideal recovery"
        ],
        "authors": [
            {
                "name": "SHI Lin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "WANG Yi-wei",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Information Engineering University",
        "year": 2012
    },
    "vbLcif1Q": {
        "id": "vbLcif1Q",
        "title": "Design and Implementation of ECC Algorithm Unit Based on ONB over GF(2~n)",
        "abstract": "Based on optimal normal basis in GF(2n),a high speed serial-parallel elliptic curve multiplier is proposed in the paper,through introduction of operation rules in GF(2n),elliptic curves and point operation rules,with emphasis on the discussion of the ECC chip speed and hardware resource consuming,which is induced by different field partitions.The rate of point multiply is about 981 per second after FPGA validation.",
        "keywords": [
            "ECC",
            "Elliptic curve",
            "Optimal normal base",
            "Point multiplication operation"
        ],
        "authors": [
            {
                "name": "CHEN Tao",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2007
    },
    "poUbiIbb": {
        "id": "poUbiIbb",
        "title": "Design and implementation of cryptogram service composition model based on Abstract service",
        "abstract": "To improve the quality of cryptogram service and extend its application area,the services is Abstracted and classified on the basis of these characteristics.In this foundation,combining service oriented architecture and using the pi-calculus-based modeling of BPEL,the cryptogram service composition model with dynamic scheduling and intelligent optimization is designed.Using the model,the business process can be graphical created,and the process is dealt with the formal analysis and correctness test.Finally a prototype system is realized and its design and implementation strategies are given.",
        "keywords": [
            "Abstract service",
            "prototype system",
            "service composition",
            "cryptogram service",
            "Pi calculus"
        ],
        "authors": [
            {
                "name": "LI Jian-jun",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China;Science and Technology on Information Assurance Laboratory,Beijing ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "CHEN Wu-ping",
                "org": "Science and Technology on Information Assurance Laboratory,Beijing ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2012
    },
    "a2ilEGaV": {
        "id": "a2ilEGaV",
        "title": "Anti-cheating visual cryptography scheme based on probability",
        "abstract": "An anti-cheating Visual Cryptography Scheme(VCS) scheme based on probability,which can find the cheaters without extra information,was proposed.Meanwhile,the visual effects of recovered secret image could be controlled in this scheme.Performance analysis and simulation results show that this scheme has little pixel expansion and the visual effect of recovered secret image can be adjusted by controlling probability.",
        "keywords": [
            "share",
            "visual cryptography",
            "probability",
            "cheater"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou Henan ,China"
            },
            {
                "name": "WANG Yi-wei",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou Henan ,China"
            },
            {
                "name": "FANG Li-guo",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou Henan ,China"
            }
        ],
        "venue": "Journal of Computer Applications",
        "year": 2009
    },
    "FjeoHMa3": {
        "id": "FjeoHMa3",
        "title": "Design and Implementation of Encryption Scheme of Bluetooth Communication",
        "abstract": "Aiming at the exhaustive attack and Man in The Middle attack on the key, algebra attack on E0 algorithm of the baseband encryption scheme, this paper proposes a new encryption scheme on the HCI layer, based on the features of Bluetooth devices. It protects the security of key with improved ECDH protocol. Experiment demonstrates the scheme provides more security mechanism and solves the impact on communication under reliable transmission, and the style of improved AES algorithm has less impact on communication.",
        "keywords": [
            "AES algorithm",
            "encryption scheme",
            "Bluetooth security"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology, PLA Information Engineering University, Zhengzhou "
            },
            {
                "name": "LI Ying-chuan",
                "org": "Institute of Electronic Technology, PLA Information Engineering University, Zhengzhou "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2009
    },
    "tTSAZrZJ": {
        "id": "tTSAZrZJ",
        "title": "The Fast Implementation for Computing Multiplicative Inverse over Galois Fields",
        "abstract": "A design of the Galois Field Multiply hardware in a series-parallel associative configuration to do the calculation of multiplicative inverse is presented in this paper.And the analysis with the area and performance is also provided.Through the design,we get a high efficient result,and it is suitable for implementation of the FPGA.",
        "keywords": [
            "Finite field",
            "ECC",
            "Multiplicative inverse"
        ],
        "authors": [
            {
                "name": "CAI Zhen-guo",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "CHEN Tao",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Microprocessors",
        "year": 2006
    },
    "E3OLZRDi": {
        "id": "E3OLZRDi",
        "title": "XOR-based(2,2,n) multi-secret visual cryptography",
        "abstract": "Aiming at the large pixel expansion and low relative difference among the existing multi-secret visual cryptography schemes,starting with the relationship between the pixel expansion and the number of secret images,this paper proposed a XOR-based(2,2,n) multi-secret visual cryptography scheme through the relation algorithm and the share algorithm.This scheme could reconstructed any amount of secret images not only with the XOR operation but also with the OR operation.The experimental results demonstrate that the pixel expansion and relative difference are improved compared with the previous schemes.",
        "keywords": [
            "pixel expansion",
            "multi-secret",
            "XOR",
            "visual cryptography",
            "relative difference"
        ],
        "authors": [
            {
                "name": "SHEN Gang",
                "org": "PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "FU Zheng-xin",
                "org": "PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2012
    },
    "GzUvvsSj": {
        "id": "GzUvvsSj",
        "title": "Research on a Cheater Preventable VCS with Pixel Unexpanded",
        "abstract": "Through analyzing the security and contrast of the cheater preventable VCS,and constructing optimization model,a cheater preventable VCS with pixel unexpanded is constructed in this paper.Performance analysis and simulation results show that the scheme has less pixel expansion and can find more cheaters by stacking the shares.",
        "keywords": [
            "contrast",
            "share",
            "visual cryptography",
            "security",
            "cheater"
        ],
        "authors": [
            {
                "name": "WANG Yi-wei",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "FU Zheng-xin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "FANG Li-guo",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Information Engineering University",
        "year": 2011
    },
    "h8Rbp4Ku": {
        "id": "h8Rbp4Ku",
        "title": "Integrality Authentication Scheme of Bluetooth Baseband Packet Header Based on Key Stream.",
        "abstract": "To resolve the problem of lacking integrality authentication on bluetooth baseband packet header, an algorithm of short message integrality authentication was designed. On the basis of the algorithm, an integrality authentication scheme of bluetooth baseband packet header was designed. The theoretical analysis and simulation results show it can guarantee the integrality of bluetooth baseband packet header with high data transmission efficiency and low computing cost.",
        "keywords": [
            "Bluetooth",
            "Integrality",
            "Key stream",
            "Baseband"
        ],
        "authors": [
            {
                "name": "Shun Zhang",
                "org": "Informat Engn Univ, Inst Elect Technol, Zhengzhou, Henan Province, Peoples R China"
            },
            {
                "name": "Liandong Liu",
                "org": "Informat Engn Univ, Inst Elect Technol, Zhengzhou, Henan Province, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Informat Engn Univ, Inst Elect Technol, Zhengzhou, Henan Province, Peoples R China"
            }
        ],
        "venue": "Communications in Computer and Information Science",
        "year": 2011
    },
    "S9ZL2sU2": {
        "id": "S9ZL2sU2",
        "title": "Study on electromagnetic compromising emanations of computer keyboard and its protection",
        "abstract": "This paper studied the circuit structure characteristic of data and clock signal interface in the PS/2 keyboard's control module.On this basis,it used the method of equivalent circuit to research the electromagnetic compromising emanations and its information recovery mechanism,the effectiveness of which was test and verified by a later measurement experiment.Furthermore,it proposed two different ways of security protection,and designed a shielding protection method against compromising emanations of keyboard.It is demonstrated by the result of the experiment that electromagnetic emission of keyboard is suppressed effectively and good protection effect against keystroke recovery is reached.",
        "keywords": [
            "falling edge",
            "electromagnetic compromising emanations",
            "security protection",
            "information security"
        ],
        "authors": [
            {
                "name": "WANG Li-tao",
                "org": "Institute of Electronic Technology,The PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,The PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2012
    },
    "2iJUilTJ": {
        "id": "2iJUilTJ",
        "title": "Identity-based authentication scheme for ZigBee nodes",
        "abstract": "ZigBee specifications and kinds of identity-based authentication schemes are researched in-depth.Aiming at solving the issues of lack of identity authentication when nodes compose a ZigBee network,an identity-based ZigBee identity authentication scheme using weil pairing on ellipse curve is proposed.Based on the scheme,the implementation of mutual identity authentication is simultaneous with the establishment of ZigBee link key between ZigBee nodes.Experiments show that the proposed scheme bears the advantage of identity-based authentication scheme and has high security and extensibility.Besides,the scheme has the advantage of limited resource cost.",
        "keywords": [
            "identity-based cryptography",
            "weil pairing",
            "ellipse curve",
            "ZigBee network",
            "mutual identity authentication"
        ],
        "authors": [
            {
                "name": "YANG Tong-hao",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2012
    },
    "kvoAsumx": {
        "id": "kvoAsumx",
        "title": "Design and implementation of ECC chip based on ONB over GF(2~n)",
        "abstract": "This paper analyzes the elliptic curves operation rules,presents a high speed serial-parallel elliptic curve multiplier for the Galois field GF(2~n) which based on optimal normal basis,compares the ECC chip speed and hardware resource consuming induced by the different field partition.The proposed multiplier requires 183 clocks for point addition,175 clocks for point doubling and 133 clocks for multiplicative inverse computing.The rate of point multiplication is about 981 per second after FPGA validation.",
        "keywords": [
            "optimal normal base",
            "elliptic curve",
            "ECC",
            "point multiplication operation"
        ],
        "authors": [
            {
                "name": "CHEN Tao",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Applications",
        "year": 2007
    },
    "NZZvth1n": {
        "id": "NZZvth1n",
        "title": "Research of bluetooth video transport mechanism with QoS guaranteed",
        "abstract": "The existed bluetooth video transport system can’t guarantee the image quality under different network conditions.Based on analysis of existing bluetooth video specification,design a mechanism that provide guaranteed QoS of bluetooth video transport.It works with business categorizing and optimizing buffer size,and efficiently improves the video transport performance in different circumstances.Simulation results demonstrate that the mechanism is feasible and efficient.",
        "keywords": [
            "QoS",
            "video transport",
            "bluetooth",
            "business categorizing",
            "bandwidth"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": " Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "LIANG Jun-xue",
                "org": " Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YUE Yun-tian",
                "org": " Institute of Electronic Technology,the PLA Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Applications",
        "year": 2008
    },
    "XDXz0AaZ": {
        "id": "XDXz0AaZ",
        "title": "Multilevel Security Policy Model Combined with User Permission",
        "abstract": "Aiming at the problem that BLP model's access rule of \"no write down\" destroy data integrity,subject has most privilege and object holds constant security level,this paper presents a multilevel security policy model combined with user permission. In the model,trusted label is used in subject writing to protect object integrity. User permission solves the problem that subject privilege in BLP model and trusted label has more rights to steal data. By importing arbitration for system administrator,confidential label and trusted label for the modified objects is adjusted dynamically. Theory analysis indicates that the model can assure system security.",
        "keywords": [
            "trusted label",
            "security model",
            "user permission"
        ],
        "authors": [
            {
                "name": "LU Xiao-liang",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            },
            {
                "name": "YU Bin",
                "org": "Institute of Electronic Technology,PLA Information Engineering University,Zhengzhou "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2010
    },
    "RdWOkvWB": {
        "id": "RdWOkvWB",
        "title": "Design and implementation of USB IP core with identity authentication function",
        "abstract": "The data security in the USB storage device can not be properly guaranteed due to the problem that the identity authentication mechanism of the USB device can be easily bypassed.A secure USB IP core architecture is proposed in this paper,and an identity authentication protocol which is suitable for USB communication system is designed.Furthermore,the secure USB IP Core is implemented which can respond to the host identity request at bus interface level.Experimental results demonstrate that the secure USB IP core can provide unified identity authentication service for the USB device's function level and is of high security.",
        "keywords": [
            "IP core",
            "identity authentication protocol",
            "USB device controller",
            "secure USB"
        ],
        "authors": [
            {
                "name": "LI Cui",
                "org": "The Third Institute,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "REN Jie",
                "org": "The Third Institute,Information Engineering University,Zhengzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "The Third Institute,Information Engineering University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Hefei University of Technology(Natural Science)",
        "year": 2013
    },
    "oygrGKKj": {
        "id": "oygrGKKj",
        "title": "A Review of Atmosphere–Ocean Forcings Outside the Tropical Pacific on the El Niño–Southern Oscillation Occurrence",
        "abstract": "The El Nino–Southern Oscillation (ENSO) is the strongest interannual air–sea coupled variability mode in the tropics, and substantially impacts the global weather and climate. Hence, it is important to improve our understanding of the ENSO variability. Besides the well-known air–sea interaction process over the tropical Pacific, recent studies indicated that atmospheric and oceanic forcings outside the tropical Pacific also play important roles in impacting and modulating the ENSO occurrence. This paper reviews the impacts of the atmosphere–ocean variability outside the tropical Pacific on the ENSO variability, as well as their associated physical processes. The review begins with the contribution of the atmosphere–ocean forcings over the extratropical North Pacific, Atlantic, and Indian Ocean on the ENSO occurrence. Then, an overview of the extratropical atmospheric forcings over the Northern Hemisphere (including the Arctic Oscillation and the Asian monsoon systems) and the Southern Hemisphere (including the Antarctic Oscillation and the Pacific–South American teleconnection), on the ENSO occurrence, is presented. It is shown that the westerly (easterly) wind anomaly over the tropical western Pacific is essential for the occurrence of an El Nino (a La Nina) event. The wind anomalies over the tropical western Pacific also play a key role in relaying the impacts of the atmosphere–ocean forcings outside the tropical Pacific on the ENSO variability. Finally, some relevant questions, that remain to be explored, are discussed.",
        "keywords": "",
        "authors": [
            {
                "name": "Shangfeng Chen",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Wen Chen",
                "org": ""
            },
            {
                "name": "Renguang Wu",
                "org": ""
            }
        ],
        "venue": "Atmosphere",
        "year": 2018
    },
    "PLCR3mSY": {
        "id": "PLCR3mSY",
        "title": "Asymmetric influence of boreal spring Arctic Oscillation on subsequent ENSO",
        "abstract": "",
        "keywords": [
            "enso",
            "atmospheric circulation"
        ],
        "authors": [
            {
                "name": "shangfeng chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "wen chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "bin yu",
                "org": "environment canada"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "5qrIDEUy": {
        "id": "5qrIDEUy",
        "title": "Modulation of the seasonal footprinting mechanism by the boreal spring Arctic Oscillation: MODULATION OF THE SFM BY AO",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hansf graf",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "wen chen",
                "org": ""
            },
            {
                "name": "shangfeng chen",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2013
    },
    "cbjzlUk0": {
        "id": "cbjzlUk0",
        "title": "The influence of boreal spring Arctic Oscillation on the subsequent winter ENSO in CMIP5 models",
        "abstract": "This study examines the influence of boreal spring Arctic Oscillation (AO) on the subsequent winter El Niño-Southern Oscillation (ENSO) using 15 climate model outputs from the Coupled Model Intercomparison Project Phase 5 (CMIP5). Results show that, out of the 15 CMIP5 models, CCSM4 and CNRM-CM5 can well reproduce the significant AO–ENSO connection. These two models capture the observed spring AO related anomalous cyclone (anticyclone) over the subtropical western-central North Pacific, and westerly (easterly) winds over the tropical western-central Pacific. In contrast, the spring AO-related anomalous circulation over the subtropical North Pacific is insignificant in the other 13 models, and the simulations in these models cannot capture the significant influence of the spring AO on ENSO. Further analyses indicate that the performance of the CMIP5 simulations in reproducing the AO–ENSO connection is related to the ability in simulating the spring North Pacific synoptic eddy intensity and the spring AO’s Pacific component. Strong synoptic-scale eddy intensity results in a strong synoptic eddy feedback on the mean flow, leading to strong cyclonic circulation anomalies over the subtropical North Pacific, which contributes to a significant AO–ENSO connection. In addition, a strong spring AO’s Pacific component and associated easterly wind anomalies to its south may provide more favorable conditions for the development of spring AO-related cyclonic circulation anomalies over the subtropical North Pacific.",
        "keywords": [
            "AO",
            "ENSO",
            "CMIP5",
            "Synoptic-scale eddy"
        ],
        "authors": [
            {
                "name": "Shangfeng Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing,China"
            },
            {
                "name": "Wen Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing,China"
            },
            {
                "name": "Bin Yu",
                "org": "Climate Research Division,Environment and Climate Change Canada,Toronto,Canada"
            }
        ],
        "venue": "Climate Dynamics",
        "year": 2017
    },
    "L4MePJ26": {
        "id": "L4MePJ26",
        "title": "Genesis of westerly wind bursts over the equatorial western Pacific during the onset of the strong 2015–2016 El Niño",
        "abstract": "The strong 2015–2016 El Nino was initiated by several strong westerly wind bursts over the equatorial western Pacific in March and May 2015. These westerly wind bursts trigger eastward propagating warm Kelvin waves and lead to large sea surface temperature (SST) warming in the equatorial eastern Pacific. The first burst of westerly winds in early March was mainly induced by the Arctic Oscillation (AO) event. These westerly wind anomalies were enhanced subsequently due to the Madden-Julian Oscillation activity and northerly cold surges from East Asia-western Pacific in mid-March. Another westerly wind burst in May, induced by anomalous southerly winds from the Australian continent, further increased the SST anomaly in the equatorial eastern Pacific. This study provides an evidence of the AO influence on this strong El Nino-Southern Oscillation (ENSO) event and demonstrates the complexity in the genesis of westerly wind bursts during the El Nino outbreak, which may help improve the prediction of ENSO.",
        "keywords": "",
        "authors": [
            {
                "name": "Shangfeng Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China"
            },
            {
                "name": "Renguang Wu",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China"
            },
            {
                "name": "Wen Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China"
            },
            {
                "name": "Bin Yu",
                "org": "Climate Research Division Environment and Climate Change Canada Toronto ON Canada"
            },
            {
                "name": "Xi Cao",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics Chinese Academy of Sciences Beijing China"
            }
        ],
        "venue": "Atmospheric Science Letters",
        "year": 2016
    },
    "P3G3gT5P": {
        "id": "P3G3gT5P",
        "title": "Influence of the November Arctic Oscillation on the subsequent tropical Pacific sea surface temperature",
        "abstract": "",
        "keywords": [
            "atmospheric circulation"
        ],
        "authors": [
            {
                "name": "shangfeng chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "renguang wu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "wen chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "bin yu",
                "org": "environment canada"
            }
        ],
        "venue": "International Journal of Climatology",
        "year": 2015
    },
    "IsTua14l": {
        "id": "IsTua14l",
        "title": "Recent Strengthening of the Regional Hadley Circulation over the Western Pacific during Boreal Spring",
        "abstract": "Previous studies suggested that there are large discrepancies in the intensity trend of the zonally averaged Hadley circulation (ZAHC) among different reanalyses. As the land, ocean, and topography are not evenly distributed, the ZAHC may mask the regional variability. Changes in the regional HC have important implications for regional climate change. Here, we detect the long-term trend of the boreal spring regional Hadley circulation intensity over the western Pacific (WPHC) since 1979 in both hemispheres using six reanalysis datasets. Unlike the ZAHC, we find that the trend of the spring WPHC intensity is consistent among various reanalysis datasets. All reanalyses show pronounced strengthening trends for the WPHC in both the Northern and Southern Hemisphere, which may be partly attributable to the robust warming trends of sea surface temperature in the tropical western Pacific. The result could improve our understanding of Hadley circulation variability at the regional scale and has implications for regional climate changes.",
        "keywords": [
            "regional Hadley circulation",
            " western Pacific",
            " long-term trend",
            " boreal spring",
            " 区域哈德莱环流",
            " 西太平洋",
            " 长期趋势",
            " 春季"
        ],
        "authors": [
            {
                "name": "Ruping Huang",
                "org": "Guangzhou Institute of Tropical and Marine Meteorology, China Meteorological Administration, Guangzhou, China"
            },
            {
                "name": "Shangfeng Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Wen Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Peng Hu",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Bin Yu",
                "org": "Climate Research Division, Environment and Climate Change Canada, Toronto, Canada"
            }
        ],
        "venue": "Advances in Atmospheric Sciences",
        "year": 2019
    },
    "XNCYxHux": {
        "id": "XNCYxHux",
        "title": "An interdecadal change in the influence of the spring Arctic Oscillation on the subsequent ENSO around the early 1970s",
        "abstract": "Previous studies suggested that the springtime Arctic Oscillation (AO) influences the El Niño-Southern Oscillation (ENSO) outbreak in the following winter. Using the HadISST, HadSLP2r, ERSSTv3b and NCEP-NCAR reanalysis data for the period 1948–2012, this analysis further reveals that the AO–ENSO relationship experienced a pronounced interdecadal shift. The spring AO influence on the subsequent ENSO is weak before 1970; while the influence becomes strong and statistically significant in the 1970s and 1980s. We then compare the spring AO associated circulation, SST and precipitation anomalies between the PRE (1949–1968) and POST (1970–1989) epochs to explore this interdecadal change of the AO–ENSO relationship. The spring AO-related anomalies of atmospheric circulation over the North Pacific mid-latitudes, cyclonic circulation over the subtropical western-central Pacific, and westerly winds in the tropical western-central Pacific are found to be stronger in the POST epoch than in the PRE epoch. The intensity of spring Pacific synoptic-scale eddy activity is seen to experience a significant interdecadal change around the early-1970s from a weak regime to a strong regime. Thus the strength of synoptic-scale eddy feedback to the low frequency flow becomes stronger after 1970. In the POST epoch, the strong synoptic-scale eddy feedback provides a favorable condition for the formulation of the spring AO-related cyclonic circulation and westerly wind anomalies over the western North Pacific. The tropical SST, precipitation and atmospheric circulation anomalies sustain and develop from spring to winter through the positive Bjerknes feedback, leading to an El Niño-like warming in the tropical central-eastern Pacific in the following winter.",
        "keywords": [
            "AO",
            " ENSO",
            " Interdecadal shift",
            " Atmospheric circulation",
            " Synoptic-scale eddy activity"
        ],
        "authors": [
            {
                "name": "shangfeng chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing,China"
            },
            {
                "name": "bin yu",
                "org": "Climate Research Division,Environment Canada,Toronto,Canada"
            },
            {
                "name": "wen chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing,China"
            }
        ],
        "venue": "Climate Dynamics",
        "year": 2014
    },
    "nzedX0AJ": {
        "id": "nzedX0AJ",
        "title": "Recent weakening of the linkage between the spring Arctic Oscillation and the following winter El Niño-Southern Oscillation",
        "abstract": "Previous studies indicated that the spring Arctic Oscillation (AO) is an important extratropical forcing of the occurrence of El Niño-Southern Oscillation (ENSO) in the following winter. This study reveals an interdecadal weakening in the spring AO-winter ENSO connection around the early-1990s and investigates the reason of this change. Before the early-1990s, in association with the positive phase of the spring AO, an anomalous anticyclone appears over the mid-latitude North Pacific, accompanied by an anomalous cyclone over the subtropical North Pacific that is supported by the wave-mean flow interaction. Correspondingly, the sea surface temperature (SST) warming and its associated positive precipitation anomalies develop over the subtropical North Pacific, which play a crucial role in forming and maintaining the westerly wind anomalies over the tropical western Pacific (TWP) from spring to the following summer. The TWP westerly wind anomalies would induce the El Niño event in the following winter. After the early-1990s, by contrast, the Pacific component of the circulation anomalies related to the spring AO is weak and shifts northward. This is followed by weak anomalies of SST and precipitation over the subtropical North Pacific, as well as weak TWP westerly wind anomalies from spring to the following summer. Hence, the spring AO-winter ENSO connection is weak after the early-1990s. The change of the spring AO associated circulation anomalies over the North Pacific around the early-1990s tends to be related to the interdecadal change in the intensity of the Aleutian Low.",
        "keywords": [
            "Spring Arctic Oscillation",
            " ENSO",
            " Interdecadal change",
            " Early-1990s"
        ],
        "authors": [
            {
                "name": "Shangfeng Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Renguang Wu",
                "org": "School of Earth Sciences, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Wen Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Bin Yu",
                "org": "Climate Research Division, Environment and Climate Change Canada, Toronto, Canada"
            }
        ],
        "venue": "Climate Dynamics",
        "year": 2019
    },
    "nYotIlvv": {
        "id": "nYotIlvv",
        "title": "Interannual variations of the rainy season withdrawal of the monsoon transitional zone in China",
        "abstract": "The monsoon transitional zone (MTZ) is the interactional belt between humid and arid regions. This study examines the interannual variation of the MTZ rainy season withdrawal over China. A withdrawal index is firstly defined according to pentad mean precipitation data. The index shows pronounced interannual variations, with a significant dominant period around 2–4 years. When the withdrawal of the MTZ rainy season is later than normal, pronounced precipitation increase appears over the MTZ in August. Meanwhile, a significant anticyclonic anomaly appears over the tropical western North Pacific (WNP) and a marked atmospheric wave train is seen originating from the North Atlantic and flowing across Eurasia to East Asia. Both the anomalous anticyclone over the WNP and the negative geopotential height anomalies related to the Eurasian wave train around the MTZ contribute to the precipitation increase over the MTZ in August, and lead to the late withdrawal of the MTZ rainy season in China. It is showed that preceding winter El Niño-like events have a contribution to the generation of anticyclonic anomalies over the WNP. In addition, the northern tropical Atlantic (NTA) sea surface temperature (SST) warming, which is independent of the preceding winter El Niño, is found to play a crucial role in the formation of the WNP anticyclone and the Eurasian atmospheric wave train. The importance of the NTA SST anomalies on the MTZ rainy season withdrawal is also confirmed by a set of atmospheric general circulation model experiments.",
        "keywords": [
            "Monsoon transitional zone",
            " Withdrawal of rainy season",
            " Northern tropical Atlantic SST",
            " WNP anticyclone",
            " Eurasian atmospheric teleconnection"
        ],
        "authors": [
            {
                "name": "Wei Zhao",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Shangfeng Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Wen Chen",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Shuailei Yao",
                "org": "State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Debashis Nath",
                "org": "Center for Monsoon System Research, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Bin Yu",
                "org": "Climate Research Division, Environment and Climate Change Canada, Toronto, Canada"
            }
        ],
        "venue": "Climate Dynamics",
        "year": 2019
    },
    "liOo2fxb": {
        "id": "liOo2fxb",
        "title": "Asymmetric influence of boreal spring Arctic Oscillation on subsequent ENSO: ASYMMETRIC INFLUENCE OF AO ON ENSO",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "wen chen",
                "org": ""
            },
            {
                "name": "shangfeng chen",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "3xKXi6JR": {
        "id": "3xKXi6JR",
        "title": "Application of secondary steel slag in subgrade: Performance evaluation and enhancement",
        "abstract": "Abstract   Steel slag accumulates heavily in China and has caused significant environmental burdens. In this study, secondary steel slag (SSS) was used a potential material in subgrade treatment. This study first blended SSS of different contents with lime soil and inspected the performances of the mixes in terms of compactability, strength and expansion ratio. The optimum treatment effect was obtained at a proportion of 50% SSS, 45% soil and 5% lime. Scanning electron microscopy test was conducted to reveal the strength development of SSS lime soil. The components of SSS were then supplemented by lime and metakaolin referring to the oxide compositions and proportions of the Portland cement. The unconfined compressive strength (UCS) of the reconstituted SSS increased from 0.73 MPa (plain SSS) to 4.09 MPa at 28d. Three agents, NaOH, NaCl and Na 2 SO 4 , were selected to further improve the activity of the reconstituted SSS. At the content of 5%, the UCSs of the specimens activated by NaCl and Na 2 SO 4  increased to 8.02 MPa and 10.88 MPa at 28d, respectively. The reconstitution and activation of SSS is an effective way to improve the performance in subgrade treatment.",
        "keywords": "",
        "authors": [
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing, 210096, China"
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Qiao Dong",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing, 210096, China"
            },
            {
                "name": "Yongfeng Deng",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing, 210096, China"
            }
        ],
        "venue": "Journal of Cleaner Production",
        "year": 2018
    },
    "fWIHpucg": {
        "id": "fWIHpucg",
        "title": "Estimation of albedo effect in pavement life cycle assessment",
        "abstract": "In the modeling of life cycle assessment (LCA) of pavement, the usage module is un-avoidable to reach comprehensive conclusions but far from perfect till date. Typically, the usage module consists of rolling resistance, albedo, lighting requirement, carbonation (for cement concrete pavement), leachate, and others. None of the aforementioned components is well studied among the pavement community. This research makes contribution to better modeling of the albedo effect of pavements, a traditionally ignored aspect. A time-dependent climatological model was developed to estimate the CO2 offset due to pavement albedo in the life cycle, in an either deterministic or probabilistic mode. A case study suggests that the albedo effect produces a non-negligible contribution to the life cycle inventory. Specifically, it reduces the CO2-equivalent emission for the portland cement concrete pavement by 9.2% but increases 19.1% for the hot mixture asphalt pavement.",
        "keywords": [
            "LCA",
            "Pavement",
            "Albedo",
            "CO2"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "Corresponding author. Tel.: +1 813 300 5735."
            },
            {
                "name": "qing lu",
                "org": "Tel.: +1 813 974 5822."
            }
        ],
        "venue": "Journal of Cleaner Production",
        "year": 2014
    },
    "SXG1oP4f": {
        "id": "SXG1oP4f",
        "title": "Multi-objective optimisation of hot in-place recycling of asphalt pavement considering environmental impact, cost and construction quality",
        "abstract": "ABSTRACTHot in-place recycling (HIR) of asphalt pavement is deemed as an environmental-friendly maintenance measure. Cost and construction quality were concerned conventionally in the HIR practice despite the HIR construction process itself producing substantial environmental burdens. In this study, a multi-objective optimisation model was therefore developed considering the environmental impact, cost and construction quality for HIR practice. Environmental impact was quantified based on discrete-event simulation (DES), which can capture the uncertainty of construction activity and the idling state of equipment. Cost comes from material input, fuel consumption and equipment usage. Compaction degree and construction reliability were used as proxies of construction quality. The non-dominated sorting genetic algorithm II (NSGAII) was employed to solve the multi-objective optimisation problem and obtained 20 sets of Pareto optimal solutions. The results suggested there is an opportunity to reduce the environm...",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": "School of Transportation, Southeast University, Nanjing, People's Republic of China"
            },
            {
                "name": "Xiangcheng Meng",
                "org": "School of Transportation, Southeast University, Nanjing, People's Republic of China"
            },
            {
                "name": "Qiang Liu",
                "org": "School of Transportation, Southeast University, Nanjing, People's Republic of China"
            }
        ],
        "venue": "International Journal of Pavement Engineering",
        "year": 2018
    },
    "d0ugTDmC": {
        "id": "d0ugTDmC",
        "title": "Life cycle assessment of pavement: Methodology and case study",
        "abstract": "A life cycle assessment model is built to estimate the environmental implications of pavements using material, distribution, construction, congestion, usage, and end of life modules. A case study of three overlay systems, Portland cement concrete overlay, hot mixture asphalt overlay, and crack, seat, and overlay, is presented. The case leads to the following conclusions. It is reasonable to expect less environmental burdens from the Portland cement concrete and crack, seat, and overlay options as opposed to hot mixture asphalt while although the results have a high degree uncertainties. The material, congestion, and particularly usage modules contribute most to energy consumption and air pollutant. Traffic related energy consumption and greenhouse gases are sensitive to traffic growth and fuel economy improvement. Uncertainties exist in the usage module, especially for the pavement structure effect. (C) 2012 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "Pavement design",
            "Infrastructure life cycle assessment",
            "Pavement overlay systems"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "Univ S Florida, Tampa, FL 33620 USA"
            },
            {
                "name": "qing lu",
                "org": "Univ S Florida, Tampa, FL 33620 USA"
            }
        ],
        "venue": "TRANSPORTATION RESEARCH PART D-TRANSPORT AND ENVIRONMENT",
        "year": 2012
    },
    "JWjJTM2R": {
        "id": "JWjJTM2R",
        "title": "Environmental Implications of Pavements: A Life Cycle View",
        "abstract": "",
        "keywords": [
            "optimization",
            "greenhouse gases"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "FcVmYA8g": {
        "id": "FcVmYA8g",
        "title": "Characterization of Fatigue Damage of Hot Mix Asphalt Based on Residual Strength",
        "abstract": "<p>This study carried out laboratory investigations of fatigue damage development of hot mix asphalt (HMA) by semicircular bending (SCB) test. Strength of the HMA specimen was first investigated at different loading rates, the results of which indicate an exponential relationship between strength and loading rate. The SCB fatigue test at stress-control mode was then performed at six levels of stress-strength ratio (SSR). Two fatigue life prediction models have been established accordingly based on the concepts of the nominal SSR and the authentic SSR. The latter model can better predict fatigue behaviors. As follows, another round of SCB fatigue test was continued to investigate the relationship between residual strength and fatigue damage evolution. Analysis of test results indicate that fatigue damage evolution is nonlinear and consists of two components: the accumulative damage development and last-cycle damage jump. A fatigue damage evolution model has been finally built based on the residual strength, which can capture the “sudden death” phenomenon of the fatigue damage process at stress-control mode.</p>",
        "keywords": [
            "Laboratory tests",
            "Asphalts",
            "Damage (material)",
            "Residual strength",
            "Materials processing",
            "Concrete",
            "Fatigue (material)",
            "Strength of materials"
        ],
        "authors": [
            {
                "name": "Fujian Ni",
                "org": "Professor, School of Transportation, Southeast Univ., Nanjing 210096, China."
            },
            {
                "name": "Bin Yu",
                "org": "Associate Professor, School of Transportation, Southeast Univ., Nanjing 210096, China (corresponding author)."
            },
            {
                "name": "Xingyu Gu",
                "org": "Associate Professor, School of Transportation, Southeast Univ., Nanjing 210096, China."
            },
            {
                "name": "Kai Xu",
                "org": "Master’s Student, School of Transportation, Southeast Univ., Nanjing 210096, China."
            }
        ],
        "venue": "Journal of Materials in Civil Engineering",
        "year": 2017
    },
    "dCAlyPbM": {
        "id": "dCAlyPbM",
        "title": "Environmental burden evaluation of hot in-place recycling of asphalt pavement based on discrete event simulation",
        "abstract": "Abstract   Hot in-place recycling (HIR) is deemed as an environmental-friendly maintenance measure of asphalt pavement due to its complete recycling of aged asphalt mixture. However, the environmental burden of HIR process itself is remarkable but has been conventionally ignored. This study presented a discrete event simulation (DES) method to estimate and compare the environmental burdens of two HIR methods, the remixing method (A) and the repaving method (B). The simulation results indicated: (1) with the same paving mass, the emissions of A were greater than those of B by 19–21%; (2) with the same paving length, the emissions of A were less than those of B by 23–26%. Optimizations of the construction process were further conducted considering air emission, fuel consumption and construction time. Optimal truck number subject to transportation distance was recommended. And the impact of increasing truck capacity and altering truck dumping process calculated, with the former decreasing environmental burdens and the latter bringing trivial benefit. The developed DES model provides quantitative estimations of environmental burdens and allows for optimization of HIR construction process subject to field conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Shuyi Wang",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            },
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            },
            {
                "name": "Fujian Ni",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            },
            {
                "name": "Qiang Liu",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            }
        ],
        "venue": "Transportation Research Part D-transport and Environment",
        "year": 2018
    },
    "LBiJfP34": {
        "id": "LBiJfP34",
        "title": "Estimation and uncertainty analysis of energy consumption and CO 2 emission of asphalt pavement maintenance",
        "abstract": "Abstract   Substantial energy consumption and CO 2  emission are generated in asphalt pavement maintenance and their quantifications based on individual case are highly contingent on the input data qualities and model parameters, exhibiting high uncertainties. This study established energy consumption and CO 2  emission uncertainty assessment statistical methodology to deal with the issue. Two sources of uncertainty, the data quality one and the model parameter one, were identified. The former was captured by converting the input data to probability density function (PDF) using Beta distribution following the definitions of data quality pedigree matrix; the latter was assessed by defining uncertainty factor (UF) to determine the distribution form and parameter. Environmental data of 18 field asphalt pavement maintenance projects were collected, including hot mix asphalt (both base and SBS modified asphalts), hot in-plant recycling (15% reclaimed asphalt pavement), cold in-place recycling and cold in-plant recycling asphalt maintenance plans, covering pavement material production, transportation, mixture preparation and construction phases. The PDFs and statistical parameters (mean, standard deviation and percentiles etc.) were obtained via Monte Carlo simulation for these maintenance measures. This study further developed environmental burden comparative parameter to construct the 95% confidence intervals for the comparisons of different maintenance measures. The methodology proposed in this study captured the uncertainty of energy consumption and CO 2  emission calculation results of maintenance activity and allow researchers to evaluate the results in a statistical view.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Shuyi Wang",
                "org": ""
            },
            {
                "name": "Xingyu Gu",
                "org": ""
            },
            {
                "name": "Xingyu Gu",
                "org": ""
            }
        ],
        "venue": "Journal of Cleaner Production",
        "year": 2018
    },
    "bJwpzLbR": {
        "id": "bJwpzLbR",
        "title": "Performance Evaluation of Aged Asphalt Mix for Hot In-Place Recycling",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "fujian ni",
                "org": "southeast university"
            },
            {
                "name": "xingyu gu",
                "org": "southeast university"
            },
            {
                "name": "lidong zhang",
                "org": "southeast university"
            },
            {
                "name": "bin yu",
                "org": "southeast university"
            }
        ],
        "venue": "Journal of Testing and Evaluation",
        "year": 2015
    },
    "b5bnGHBB": {
        "id": "b5bnGHBB",
        "title": "Evaluation of plastic–rubber asphalt: Engineering property and environmental concern",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "liya jiao",
                "org": ""
            },
            {
                "name": "fujian ni",
                "org": ""
            },
            {
                "name": "jun yang",
                "org": ""
            }
        ],
        "venue": "Construction and Building Materials",
        "year": 2014
    },
    "GN5wYP1q": {
        "id": "GN5wYP1q",
        "title": "Modified repeated load tri-axial test for the high-temperature performance evaluation of HMA",
        "abstract": "",
        "keywords": [
            "temperature gradient",
            "confining pressure"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "haoran zhu",
                "org": ""
            },
            {
                "name": "xingyu gu",
                "org": ""
            },
            {
                "name": "fujian ni",
                "org": ""
            },
            {
                "name": "rui guo",
                "org": ""
            }
        ],
        "venue": "Road Materials and Pavement Design",
        "year": 2015
    },
    "J9PTgldF": {
        "id": "J9PTgldF",
        "title": "Experimental study of the bond performance and mechanical response of GFRP reinforced concrete",
        "abstract": "Abstract   This study carried out laboratory investigations of mechanical behaviors of glass fiber reinforced polymer (GFRP) concrete and consisted of three test programs. It first obtained elastic parameters of GFRP bar and then conducted pull-out test to evaluate the bond performance of GFRP/steel bar with concrete. The test variables involved diameter, thread depth, thread width, embedment length of GFRP bar and cement strength, a total of 32 combinations. Test results indicate the optimum GFRP bar is with thread gap of 0.8-diameter, thread depth of 1 mm, and in favor of small diameter size. The GFRP reinforced specimens provide approximately 60% of bond strength benchmarked by the steel reinforced specimens but have much higher slip length. Lastly, four-point bending test was applied to five types of GFRP/steel reinforced concrete beams to investigate the mechanical responses of the beams until failure. Test results indicate at the same reinforcement ratio and geometric size, GFRP bar and steel bar have the same bearing capacities. However, the former is inferior to the latter in terms of crack control.",
        "keywords": "",
        "authors": [
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Nanjing, Jiangsu 210096, China"
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Ming Wu",
                "org": "Highway Administration Bureau of Zhejiang Province, Meihuabei #4, Hangzhou, Zhejiang 310009, China"
            }
        ],
        "venue": "Construction and Building Materials",
        "year": 2016
    },
    "KUAJYvpv": {
        "id": "KUAJYvpv",
        "title": "Capturing time effect of pavement carbon footprint estimation in the life cycle",
        "abstract": "Abstract   The carbon footprint of pavement in the life cycle is regularly calculated by aggregating the inventory of greenhouse gases (GHGs) at different timings. Comparisons by the nominal values, therefore, ignore the temporal information and may lead to biased estimation of the environmental impact. This study proposed a time-dependent methodology to dynamically assess the global warming potentials (GWPs) incorporating two time parameters, time of evaluation (TE) and time horizon (TH). The former defines the time period of life cycle assessment (LCA) and the latter decides when the GWP is evaluated. Two case studies were conducted. The first case study indicated for design lives ( viz.  TE) of 20 y and 40 y, the GWPs are significantly overestimated by 59.7% and 33.0%; the second case study indicated that 66 y is the threshold value for TH that brings different policy preference for two emission plans. Together with the concept of “time dominance”, a generic implementation framework was established for the methodology so that users can justify the preferences of alternatives at any THs. The developed methodology can assist decision makers in understanding the real impacts of carbon emission within and beyond pavement life cycle.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Yue Sun",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            },
            {
                "name": "Xin Tian",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            }
        ],
        "venue": "Journal of Cleaner Production",
        "year": 2018
    },
    "6XQim7AX": {
        "id": "6XQim7AX",
        "title": "Multi-objective optimization for asphalt pavement maintenance plans at project level: Integrating performance, cost and environment",
        "abstract": "",
        "keywords": [
            "optimization",
            "multi objective optimization"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "xingyu gu",
                "org": ""
            },
            {
                "name": "fujian ni",
                "org": ""
            },
            {
                "name": "rui guo",
                "org": ""
            }
        ],
        "venue": "Transportation Research Part D-transport and Environment",
        "year": 2015
    },
    "2F1SdO84": {
        "id": "2F1SdO84",
        "title": "Empirical performance models of hot in-place recycling of asphalt pavements",
        "abstract": "AbstractHot in-place recycling (HIR) is deemed as an environmentally competing maintenance strategy to restore asphalt pavement quality. However, there is still lack of quantitative description of the long-term performances of HIR sections and in this study, field data before and after HIR implementation were collected to build empirical models for this purpose. For the rutting model, an adjusting factor was designed to calibrate the rutting development of HIR sections to account for the effect of pavement structure damage before rehabilitation. A two-stage modelling process was used to fix the zero-inflated nature of transverse crack distribution, integrating both the crack initiation and propagation model. Correlation coefficient of error terms for the two models ρ is −0.66 (p-value = 0.05), demonstrating the importance of the special treatment of ‘crack-free’ pavement sections. Smoothness and skid resistance properties in terms of international roughness index and side fiction coefficient were best des...",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Qiang Liu",
                "org": "School of Transportation, Southeast University, Nanjing, China"
            },
            {
                "name": "Xin Tian",
                "org": "School of Transportation, Southeast University, Nanjing, China"
            },
            {
                "name": "Lan Zhou",
                "org": "School of Transportation, Southeast University, Nanjing, China"
            },
            {
                "name": "Mei Lin",
                "org": "Nanjing Highway Administration Bureau, Highway Research Institute, Nanjing, China"
            }
        ],
        "venue": "International Journal of Pavement Engineering",
        "year": 2017
    },
    "zsVrx4RQ": {
        "id": "zsVrx4RQ",
        "title": "Application of a high percentage of reclaimed asphalt pavement in an asphalt mixture: blending process and performance investigation",
        "abstract": "This study performed a laboratory investigation of applying a high percentage of reclaimed asphalt pavement (RAP, up to 50%) in an asphalt mixture. The properties of aged binder were first determined and the rejuvenator and SBR latex were used to restore the binder properties. The optimum dosages of the rejuvenator and SBR additive are 2% and 4% of aged binder mass, respectively. Then the preheating temperatures of aggregate were determined according to the RAP content to meet the mixture temperature requirement. The effects of the blending process, especially the feeding sequence of materials, on the mixture performances were investigated to recommend the optimum blending process. The water durability, low-, high-temperature and fatigue performances of the mixture containing 30%, 40% and 50% RAP were examined and it was found that with the further addition of polyester fibre, the performances of an asphalt mixture containing 50% RAP can satisfy the engineering requirement.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Nanjing, People’s Republic of China"
            },
            {
                "name": "Ming Wu",
                "org": "Highway Administration Bureau of Zhejiang Province, Hangzhou, People’s Republic of China"
            },
            {
                "name": "Fujian Ni",
                "org": "School of Transportation, Southeast University, Nanjing, People’s Republic of China"
            }
        ],
        "venue": "Road Materials and Pavement Design",
        "year": 2017
    },
    "5UUXCj5r": {
        "id": "5UUXCj5r",
        "title": "Traffic Simulation Analysis on Running Speed in a Connected Vehicles Environment.",
        "abstract": "Connected vehicles (CVs) exchange a variety of information instantly with surrounding vehicles and traffic facilities, which could smooth traffic flow significantly. The objective of this paper is to analyze the effect of CVs on running speed. This study compared the delay time, travel time, and running speed in the normal and the connected states, respectively, through VISSIM (a traffic simulation software developed by PTV company in German). The optimization speed model was established to simulate the decision-makings of CVs in MATLAB, considering the parameters of vehicle distance, average speed, and acceleration, etc. After the simulation, the vehicle information including speed, travel time, and delay time under the normal and the connected states were compared and evaluated, and the influence of different CV rates on the results was analyzed. In a two-lane arterial road, running speed in the connected state increase by 4 km/h, and the total travel time and delay time decrease by 5.34% and 16.76%, respectively, compared to those in the normal state. The optimal CV market penetration rate related to running speed and delay time is 60%. This simulation-based study applies user-defined lane change and lateral behavior rules, and takes different CV rates into consideration, which is more reliable and practical to estimate the impact of CV on road traffic characteristics.",
        "keywords": [
            "VISSIM",
            "connected vehicles",
            "optimization speed model",
            "running speed"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "School of Transportation, Southeast University, Nanjing 211189, China."
            },
            {
                "name": "Miyi Wu",
                "org": "School of Transportation, Southeast University, Nanjing 211189, China."
            },
            {
                "name": "Shuyi Wang",
                "org": "School of Transportation, Southeast University, Nanjing 211189, China."
            },
            {
                "name": "Wen Zhou",
                "org": "School of Transportation, Southeast University, Nanjing 211189, China."
            }
        ],
        "venue": "International journal of environmental research and public health",
        "year": 2019
    },
    "QxAO1BYV": {
        "id": "QxAO1BYV",
        "title": "Environmental burdens of regular and long-term pavement designs: a life cycle view",
        "abstract": "",
        "keywords": [
            "fuel consumption",
            "traffic volume",
            "greenhouse gases"
        ],
        "authors": [
            {
                "name": "fei chen",
                "org": ""
            },
            {
                "name": "haoran zhu",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "haopeng wang",
                "org": ""
            }
        ],
        "venue": "International Journal of Pavement Engineering",
        "year": 2015
    },
    "pcbhvAyf": {
        "id": "pcbhvAyf",
        "title": "Laboratory Performance Evaluation of Reinforced Basalt Fiber in Sealing Asphalt Chips",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Nanjing, Jiangsu 210096, China"
            },
            {
                "name": "Xiaoyuan Zhang",
                "org": "School of Transportation, Southeast University, Nanjing, Jiangsu 210096, China"
            },
            {
                "name": "Junxiu Lv",
                "org": "School of Transportation, Southeast University, Nanjing, Jiangsu 210096, China (Corresponding author), e-mail: xyzhang_email@163.com"
            },
            {
                "name": "Z. Huang",
                "org": "School of Transportation, Southeast University, Nanjing, Jiangsu 210096, China"
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "X. Zou",
                "org": "Jinhua Highway Administration Bureau, Jinhua, Zhejiang 321103, China"
            }
        ],
        "venue": "Journal of Testing and Evaluation",
        "year": 2018
    },
    "Whv5hMVz": {
        "id": "Whv5hMVz",
        "title": "Microstructure characterization of cold in-place recycled asphalt mixtures by X-ray computed tomography",
        "abstract": "Abstract   This study investigated the microstructure features of cold in-place recycled (CIR) asphalt mixtures by the X-ray computed tomography (CT) and digital image processing (DIP) methods. A variety of CIR asphalt mixtures were prepared considering four types of aggregate gradation and three type of compaction method. The air void distribution characteristics of CIR specimens were analyzed based on the concept of air void gradation. A two-parameter Weibull function was used to fit the air void gradation, of which the statistical parameters are sensitive to both the aggregate gradation and compaction method. The concept of thickness spectrum was then developed to characterize the thickness distribution of cement asphalt (CA) mortar. Lognormal function was observed of good fitness of thickness spectrum. Finally, the uniformity index (UI) was built to evaluate the homogeneity of CIR mixtures and found the UIs of CIR mixture decreases gradually with the gradation from fine to coarse, and among the three compaction methods, the Superpave gyratory compaction is the best in terms of homogeneity. The findings of this study provide a solid foundation in exploring the internal structure and guiding the mix design of CIR mixtures.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            },
            {
                "name": "Fujian Ni",
                "org": "School of Transportation, Southeast University, Sipailou #2, Nanjing 210096, China"
            },
            {
                "name": "Lei Gao",
                "org": "Department of Civil Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China"
            }
        ],
        "venue": "Construction and Building Materials",
        "year": 2018
    },
    "pFCZUl07": {
        "id": "pFCZUl07",
        "title": "Long-term field performance of porous asphalt pavement in China",
        "abstract": "",
        "keywords": [
            "roughness",
            "china",
            "permeability",
            "noise",
            "rutting"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "liya jiao",
                "org": ""
            },
            {
                "name": "fujian ni",
                "org": ""
            },
            {
                "name": "jun yang",
                "org": ""
            }
        ],
        "venue": "Road Materials and Pavement Design",
        "year": 2014
    },
    "0rP3pKPu": {
        "id": "0rP3pKPu",
        "title": "Data quality and uncertainty assessment methodology for pavement LCA",
        "abstract": "AbstractIn performing pavement life cycle assessment (LCA), users are facing various reports of energy intensity coefficient (EIC) of pavement materials which differ considerably among data sources and therefore alter the LCA results significantly. Instead of selecting a certain EIC without or of little explanation for the current pavement LCA practices, this study proposed a methodology to build probability density function (PDF) for EIC based on available data-set and their qualities. Each data was first evaluated about the data quality indicator (DQI) through data quality pedigree matrix and converted to PDF in modified Beta distribution form. Three weighting methods, the DQI one, coefficient of variation (COV) one and analytical hierarchy process (AHP) one, were developed to assign weightings for different data. Monte Carlo simulation was run with the weighted PDF of each data as input to obtain the ultimate PDF for EIC. A case study to estimate the bitumen’s EIC with eight data samples were performed...",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Qiang Liu",
                "org": "School of Transportation, Southeast University, Nanjing, China"
            },
            {
                "name": "Xingyu Gu",
                "org": "School of Transportation, Southeast University, Nanjing, China"
            }
        ],
        "venue": "International Journal of Pavement Engineering",
        "year": 2018
    },
    "wEC28FIC": {
        "id": "wEC28FIC",
        "title": "A Novel Tumor-Suppressor, CDH18, Inhibits Glioma Cell Invasiveness Via UQCRC2 and Correlates with the Prognosis of Glioma Patients.",
        "abstract": "The present research demonstrated that CDH18 exerted its tumor-suppressor role via UQCRC2 in glioma cells and CDH18 might serve as a therapeutic target for treating gliomas.",
        "keywords": [
            "CDH18",
            "Glioma",
            "Invasion",
            "Prognosis",
            "UQCRC2"
        ],
        "authors": [
            {
                "name": "Ya-Hui Bai",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Yun-Bo Zhan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Wei-Wei Wang",
                "org": "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Li Wang",
                "org": "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Jin-Qiao Zhou",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Ruo-Kun Chen",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Xin-Wei Zhao",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Wen-Chao Duan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Yan-Min Wang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Jun Liu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Jian-Ji Bao",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Zhen-Yu Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Xian-Zhi Liu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            }
        ],
        "venue": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology",
        "year": 2018
    },
    "PGxuj6wD": {
        "id": "PGxuj6wD",
        "title": "Preliminary application of mxed reality in neurosurgery: Development and evaluation of a new intraoperative procedure.",
        "abstract": "During neurological surgery, neurosurgeons have to transform the two-dimensional (2D) sectional images into three-dimensional (3D) structures at the cognitive level. The complexity of the intracranial structures increases the difficulty and risk of neurosurgery. Mixed reality (MR) applications reduce the obstacles in the transformation from 2D images to 3D visualization of anatomical structures of central nervous system. In this study, the holographic image was established by MR using computed tomography (CT), computed tomography angiography (CTA) and magnetic resonance imaging (MRI) data of patients. The surgeon's field of vision was superimposed with the 3D model of the patient's intracranial structure displayed on the mixed reality head-mounted display (MR-HMD). The neurosurgeons practiced and evaluated the feasibility of this technique in neurosurgical cases. We developed the segmentation image masks and texture mapping including brain tissue, intracranial vessels, nerves, tumors, and their relative positions by MR technologies. The results showed that the three-dimensional imaging is in a stable state in the operating room with no significant flutter and blur. And the neurosurgeon's feedback on the comfort of the equipment and the practicality of the technology was satisfactory. In conclusion, MR technology can holographically construct a 3D digital model of patient's lesions and improve the anatomical perception of neurosurgeons during craniotomy. The feasibility of the MR-HMD application in neurosurgery is confirmed.",
        "keywords": [
            "3D",
            "Head mounted displays",
            "Image-guided surgery",
            "Mixed reality",
            "Neurosurgery"
        ],
        "authors": [
            {
                "name": "Zhen-Yu Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Wen-Chao Duan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Ruo-Kun Chen",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Yun-Bo Zhan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Ke Li",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Hai-Biao Zhao",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Tao Sun",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Yu-Chen Ji",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Ya-Hui Bai",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Yan-Min Wang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Jin-Qiao Zhou",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China."
            },
            {
                "name": "Xian-Zhi Liu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Jian She Dong Road 1, Zhengzhou, Henan 450000, China. Electronic address: xzliu06@126.com."
            }
        ],
        "venue": "Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia",
        "year": 2019
    },
    "Y9GQUFRF": {
        "id": "Y9GQUFRF",
        "title": "Prognostic value of preoperative hematological markers combined with molecular pathology in patients with diffuse gliomas.",
        "abstract": "The prediction of clinical outcome for patients with infiltrative gliomas is challenging. Although preoperative hematological markers have been proposed as predictors of survival in glioma and other cancers, systematic investigations that combine these data with other relevant clinical variables are needed to improve prognostic accuracy and patient outcomes. We investigated the prognostic value of preoperative hematological markers, alone and in combination with molecular pathology, for the survival of 592 patients with Grade II-IV diffuse gliomas. On univariate analysis, increased neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), and decreased albumin-to-globulin ratio (AGR), all predicted poor prognosis in Grade II/III gliomas. Multivariate analysis incorporating tumor status based on the presence of IDH mutations, TERT promoter mutations, and 1p/19q codeletion showed that in lower-grade gliomas, high NLR predicted poorer survival for the triple-negative, IDH mutation only, TERT mutation only, and IDH and TERT mutation groups. NLR was an independent prognostic factor in Grade IV glioma. We therefore propose a prognostic model for diffuse gliomas based on the presence of IDH and TERT promoter mutations, 1p/19q codeletion, and NLR. This model classifies lower-grade gliomas into nine subgroups that can be combined into four main risk groups based on survival projections.",
        "keywords": [
            "glioma",
            "hematological marker",
            "inflammation",
            "molecular group",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Zhen-Yu Zhang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Yun-Bo Zhan",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Yu-Chen Ji",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Jin-Qiao Zhou",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Ya-Hui Bai",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Yan-Min Wang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Li Wang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Pathol, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Yan Jing",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept MRI, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Wen-Chao Duan",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Chen Sun",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Tao Sun",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Hai-Biao Zhao",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Ke Li",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Wen-Qing Wang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Ruo-Yan Li",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept SICU, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Hong-Wei Sun",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Guang Zhai",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Shu-Kai Wang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Xin-Ting Wei",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Bo Yang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Dong-Ming Yan",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Xian-Zhi Liu",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Neurosurg, Zhengzhou 450052, Henan, Peoples R China"
            },
            {
                "name": "Wei-Wei Wang",
                "org": "Zhengzhou Univ, Affiliated Hosp 1, Dept Pathol, Zhengzhou 450052, Henan, Peoples R China"
            }
        ],
        "venue": "AGING-US",
        "year": 2019
    },
    "Edi43WDV": {
        "id": "Edi43WDV",
        "title": "Prognostic values of preoperative albumin to globulin ratio for predicting clinical outcome in patients with high-grade gliomas",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Liu",
                "org": ""
            },
            {
                "name": "Yun-Bo Zhan",
                "org": ""
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Wen-Chao Duan",
                "org": ""
            },
            {
                "name": "Wei-Wei Wang",
                "org": ""
            },
            {
                "name": "Li Wang",
                "org": ""
            },
            {
                "name": "Bo Yang",
                "org": ""
            },
            {
                "name": "Zhen-Yu Zhang",
                "org": ""
            }
        ],
        "venue": "Translational cancer research",
        "year": 2019
    },
    "tAsGfGbM": {
        "id": "tAsGfGbM",
        "title": " Preoperative Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with the Prognosis of Group 3 and Group 4 Medulloblastoma.",
        "abstract": "Inflammation and immunoreaction markers were correlated with the survival of patients in many tumors. However, there were no reports investigating the relationships between preoperative hematological markers and the prognosis of medulloblastoma (MB) patients based on the molecular subgroups (WNT, SHH, Group 3, and Group 4). A total 144 MB patients were enrolled in the study. The differences of preoperative hematological markers among molecular subgroups of MB were compared by One-way ANOVA method. Kaplan-Meier method was used to calculate the curves of progression free survival (PFS) and overall survival (OS). The comparison of survival rates in different groups were conducted by the Log-rank test. Multivariate analysis was used to evaluate independent prognostic factors. Increased preoperative NLR (neutrophil-to-lymphocyte ratio, PFS, P = 0.004, OS, P < 0.001) and PLR (platelet-to-lymphocyte ratio, PFS, P = 0.028, OS, P = 0.003) predicted poor prognosis in patients with MB, while preoperative MLR (monocyte-to-lymphocyte ratio), MPV (mean platelet volume), PDW (platelet distribution width), and AGR (albumin-to-globulin ratio) were revealed no predictive value on the prognosis of patients with MB. Furthermore, high preoperative NLR and PLR predicted unfavorable prognosis in childhood MB patients. However, preoperative NLR and PLR were not associated with the prognosis in adult MB patients. Multivariate analysis demonstrated preoperative NLR (PFS, P = 0.029, OS, P = 0.005) and PLR (PFS, P = 0.023, OS, P = 0.005) were the independent prognostic factors in MB patients. Emphatically, the levels of preoperative NLR and PLR in Group 3 MB were significantly higher than those in WNT MB. High preoperative NLR was associated with unfavorable OS in Group 3 (P = 0.032) and Group 4 (P = 0.027) tumors. Similarly, increased preoperative PLR predicted poor PFS (P = 0.012) and OS (P = 0.009) in Group 4 tumors. Preoperative NLR and PLR were the potential prognostic markers for MB patients. Preoperative NLR and PLR were significantly associated with the survival of Group 3 and Group 4 tumors.",
        "keywords": "",
        "authors": [
            {
                "name": "Ke Li",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Wen-Chao Duan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Hai-Biao Zhao",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Li Wang",
                "org": "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Wei-Wei Wang",
                "org": "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Yun-Bo Zhan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Tao Sun",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Ya-Hui Bai",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Yan-Min Wang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Yu-Chen Ji",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Jin-Qiao Zhou",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Xian-Zhi Liu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China."
            },
            {
                "name": "Zhi-Feng Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. zzfh72@sina.com."
            },
            {
                "name": "Zhen-Yu Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. neurozzy@foxmail.com."
            }
        ],
        "venue": "Scientific reports",
        "year": 2019
    },
    "FNHHUuCC": {
        "id": "FNHHUuCC",
        "title": "Regulation of UHRF1 by microRNA-378 modulates medulloblastoma cell proliferation and apoptosis.",
        "abstract": "A previous study revealed that ubiquitin-like with PHD and RING finger domains 1 (UHRF1) promoted cell proliferation and was a potential biomarker in medulloblastoma (MB). In the present study, we reported that miR-378 inhibited the expression of UHRF1 to affect the proliferation of MB through competitive binding to the same region of its 3'-UTR. We found that the expression of miR-378 was significantly downregulated in MB tissues and inversely correlated with the expression of UHRF1. Western blot analysis revealed that overexpression of miR-378 led to the suppression of UHRF1. Moreover, a dual-luciferase assay demonstrated that miR-378 negatively regulated the activity of target gene UHRF1 by binding to its 3'-UTR. An in vitro assay revealed that overexpression of miR-378 suppressed MB cell proliferation and promoted cell apoptosis. Ectopic expression of UHRF1 rescued miR-378-suppressed cell proliferation and miR-378-promoted cell apoptosis. Collectively, the present study demonstrated that miR-378 could inhibit the proliferation of MB by downregulation of UHRF1 and act as a potential therapeutic target against MB.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhen-Yu Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Bin Zhu",
                "org": "Queen Mary Institute, Nanchang University, Nanchang, Jiangxi 330000, P.R. China."
            },
            {
                "name": "Xin-Wei Zhao",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Yun-Bo Zhan",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Jian-Ji Bao",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Jin-Qiao Zhou",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Jun Liu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Yan-Min Wang",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Ya-Hui Bai",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Jin Hong",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            },
            {
                "name": "Xian-Zhi Liu",
                "org": "Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450001, P.R. China."
            }
        ],
        "venue": "Oncology reports",
        "year": 2017
    },
    "vJASoPUm": {
        "id": "vJASoPUm",
        "title": "IDH mutations but not TERTp mutations are associated with seizures in lower-grade gliomas.",
        "abstract": "Glioma is the most common malignant tumor in the central nervous system (CNS). Lower-grade gliomas (LGG) refer to Grade II and III gliomas. In LGG patients, seizure often appears as an initial symptom and play an important role in clinical performance and quality of life of the patients. To date, the relationship between the onset of seizures and the molecular pathology in gliomas is still poorly investigated. In this study, we investigate the potential relationship between isocitrate dehydrogenase (IDH)/telomerase reverse transcriptase promoter (TERTp) mutations and preoperative seizures in patients with LGG. 289 adult LGG patients were enrolled in this study. Data of clinical characteristics and molecular pathology were acquired. Sanger sequencing was used to detect IDH/TERTp mutations. Chi-square test was performed to determine if the IDH/TERTp mutations were associated with seizures and seizure types. In 289 LGG patients, preoperative seizures accounted for 25.3% (73/289), IDH mutations accounted for 34.3%(99/289), and TERTp mutations accounted for 44.3% (128/289). The correlation analysis demonstrated that IDH mutation is a significant factor influencing the occurrence of tumor-related epilepsy (P <.001, chi-square test). On the other hand, the statistical analysis revealed no significant correlation between TERTp mutations and seizure in LGG patients (P = .102, chi-square test). The tumor-related epilepsy rates vary among different subgroups according to IDH/TERTp mutations. However, there is no definite correlation between the IDH (P = 1.000, chi-square test)/TERTp (P = .613, chi-square test) mutations and the types of epileptic seizure. IDH mutations are more common in preoperative LGG patients with epileptic symptoms, suggesting that this mutation is positively correlated with seizures. However, there was no significant correlation between TERTp mutations and seizures. Different molecular pathologic types based on IDH/TERTp have different incidences of tumor-associated epilepsy in LGGs.",
        "keywords": "",
        "authors": [
            {
                "name": "Wen-Chao Duan",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Li Wang",
                "org": "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China."
            },
            {
                "name": "Ke Li",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Wei-Wei Wang",
                "org": "Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China."
            },
            {
                "name": "Yun-Bo Zhan",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Feng-Jiang Zhang",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Bin Yu",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Ya-Hui Bai",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Yan-Min Wang",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Yu-Chen Ji",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Jin-Qiao Zhou",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Xian-Zhi Liu",
                "org": "Department of Neurosurgery."
            },
            {
                "name": "Zhen-Yu Zhang",
                "org": "Department of Neurosurgery."
            }
        ],
        "venue": "Medicine",
        "year": 2018
    },
    "bwuvd43y": {
        "id": "bwuvd43y",
        "title": "SCM Tools-Aided Function Point Analysis Method",
        "abstract": "In the process of software development,if want to manage and conduct your project,have to quantify the scale and productivity.First of all,this paper introduces the function point analysis(FPA) method,with which to measure the scale and productivity.Then it describes how to utilize the metadata which extracted from SCM tools to aid the FPA and its implementation.This method could improve the reliability and real-time of the data of FPA.Furthermore,it reflects quickly when the functions of software grow or shrink.Then analyzers could recalculate the FP in time.Finally,it indirectly improves the software measurement based on FPA.",
        "keywords": [
            "function point",
            "software measurement",
            "metadata",
            "SCM"
        ],
        "authors": [
            {
                "name": "LI Cong-ting",
                "org": "Computer Science Department,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "Computer Science Department,Northwest University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2006
    },
    "oEjqezoF": {
        "id": "oEjqezoF",
        "title": "Research of Dynamic Web Service Integration Based on QoS",
        "abstract": "The former dynamic Web service integration includes many issues in reliability and effects.It is more and more important to conquer these defect with the development of the Web service.The article makes a research on effects and structure of dynamic Web service integration based on QoS(Quality of Service) in order to improve its effects and reliability.",
        "keywords": [
            "QoS",
            "Web service type",
            "dynamic Web service integration",
            "inside configuration of Web service integration"
        ],
        "authors": [
            {
                "name": "LIU Wei",
                "org": "Sch.of Info.Science and Techn.,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "Sch.of Info.Science and Techn.,Northwest University,Xi'an ,China;Dept.of Computer Science,Xidian University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2007
    },
    "3YNz41up": {
        "id": "3YNz41up",
        "title": "Research and Application of Program Understanding in the Software Maintenance",
        "abstract": "Program understanding is an essential part of all software maintenance and enhancement activities.From the view of cognizance and software maintenance,the task of program understanding is described.Moreover a set of models of program understanding is explained in this paper.At last,give some suggestion to improve program understanding.",
        "keywords": [
            "software maintenance",
            "Soloway model",
            "program understanding",
            "understanding tactical",
            "Pennington model"
        ],
        "authors": [
            {
                "name": "DING Jian-Jie",
                "org": "School of Info.Sci.& Techn.,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Info.Sci.& Techn.,Northwest University,Xi'an ,China"
            },
            {
                "name": "HOU Hong",
                "org": "School of Info.Sci.& Techn.,Northwest University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2007
    },
    "ih5Whjyb": {
        "id": "ih5Whjyb",
        "title": "Mesh simplification based on features region partition",
        "abstract": "Aim To study a mesh simplification methed for the three-dimeusional mesh model.Methods According to distribution of feature points,the face was divided into several parts,and named critical feature regional or non-critical feature regional.It adjusted different areas through giving different curvature values,this algorithm used edge collapse method to reduce the density of meshes.Results As the curvature was useful to enhance the shape description,the details of facial feature were kept while other areas were simplified in a large extent when this method was applied.Conclusion Mesh simplification method is based on features region partion for the three-dimensional mesh model.The cemplexity of these models were reduced.",
        "keywords": [
            "feature region partition",
            "discrete curvature",
            "mesh simplification",
            "edge collapse",
            "facial feature"
        ],
        "authors": [
            {
                "name": "LIU Wei-ming",
                "org": "College of Information Science and Technology,Northwest University,Xi′an ,China"
            },
            {
                "name": "WANG An-bing",
                "org": "College of Information Science and Technology,Northwest University,Xi′an ,China"
            },
            {
                "name": "SHEN Wei-chang",
                "org": "College of Information Science and Technology,Northwest University,Xi′an ,China"
            },
            {
                "name": "YU Bin",
                "org": "College of Information Science and Technology,Northwest University,Xi′an ,China"
            }
        ],
        "venue": "Journal of Northwest University(Natural Science Edition)",
        "year": 2010
    },
    "Tb9mTpfw": {
        "id": "Tb9mTpfw",
        "title": "The model checking of business process based on linear temporal logic",
        "abstract": "Aim To resolve the inconsistency between business process design and requirements.Methods A novel method is proposed,which is based on XML process definition language and linear temporal logic.Results Promela is used to describe the model of the business process,and the linear temporal logic gives the Abstract description of the business requirements.Spin model checker presents the verification results.Conclusion This method can determine the correctness of the business process.",
        "keywords": [
            "business process",
            "model checking",
            "linear temporal logic",
            "verification technology"
        ],
        "authors": [
            {
                "name": "DING Ming",
                "org": "School of Information and Technology,Northwest University,Xi′an ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Information and Technology,Northwest University,Xi′an ,China;School of Computer Science and Technolgoy,Xidian University,Xi′an ,China"
            },
            {
                "name": "CHEN Feng",
                "org": "School of Information and Technology,Northwest University,Xi′an ,China"
            },
            {
                "name": "HAO Ke-gang",
                "org": "School of Information and Technology,Northwest University,Xi′an ,China"
            }
        ],
        "venue": "Journal of Northwest University(Natural Science Edition)",
        "year": 2012
    },
    "lHN1kQR7": {
        "id": "lHN1kQR7",
        "title": "The Data Analysis Techniques in Software Measurement",
        "abstract": "From the view of statistical method,the different type of analyzing methods of software measurement is described and compared.Moreover the influence factor of data analyzed is explained in this paper.It helps us to choose right data analysis techniques in practice of software measurement,and support us to monitoring progress and decision making.",
        "keywords": [
            "control chart",
            "data analysis",
            "software measurement",
            "correlation analysis",
            "statistical method"
        ],
        "authors": [
            {
                "name": "DING Jian-jie",
                "org": "Dept.of Computer Sci.,Northwest University,Xi'an ,China"
            },
            {
                "name": "YU Bin",
                "org": "Dept.of Computer Sci.,Northwest University,Xi'an ,China"
            },
            {
                "name": "HOU Hong",
                "org": "Dept.of Computer Sci.,Northwest University,Xi'an ,China"
            },
            {
                "name": "ZHONG Xin",
                "org": "Dept.of Computer Sci.,Northwest University,Xi'an ,China"
            }
        ],
        "venue": "Computer Technology and Development",
        "year": 2006
    },
    "FvbRrSWM": {
        "id": "FvbRrSWM",
        "title": "RESEARCH ON MEASUREMENT AND APPLICATION OF SOFTWARE PRODUCT LINES",
        "abstract": "Software reuse can enhance software productivity and quality with most potential power.Software Product Lines(SPL) is the highest level of software reuse.SPL challenges nowadays the management of the software dense project.It requires managers of the strategic idea which supersedes single product.It also requires the foreseeing,probing,planning,guiding of the organization.The important thought line of software process management and mprovement is:in software development management,software measurement technology is used,namely,data support is supplied for management decision through analyzing software process and its related attributes.Concerning some critical objecte of SPL management,this paper presents some ideas of measurement technology,analyzing related measurement index and satisfying information requests of SPL management roles from different levels.",
        "keywords": [
            "Software product line Software measurement Processes management and improvement"
        ],
        "authors": [
            {
                "name": "Ning Anliang",
                "org": "Institute of Software Engineering,Department of Computer Science,Northwest University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Hou Hong",
                "org": "Institute of Software Engineering,Department of Computer Science,Northwest University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Yu Bin",
                "org": "Institute of Software Engineering,Department of Computer Science,Northwest University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Hao Kegang",
                "org": "Institute of Software Engineering,Department of Computer Science,Northwest University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Computer Applications and Software",
        "year": 2007
    },
    "6LTzQ6fl": {
        "id": "6LTzQ6fl",
        "title": "Effect of Glycosylation on Molecular Characteristics and Emulsifying Properties of Ovalbumin",
        "abstract": "【Objective】Molecular characteristics and emulsifying properties of glycosylated ovalbumin were studied to investigate the relationship between them. 【Method】 Content of free amino group, Zeta potential, hydrophobicity, emulsifying activity and average droplet size of emulsion (d32) during glycosylation process were investigated. Correlation analysis of referred factors and microscopic observation of emulsion of glycosylated ovalbumin were also conducted. 【Result】 Glycosylation reaction resulted in decrease of 41.56% of free amino group, 20 mV of Zeta potential, 2.0 μm of average droplet size of emulsion (d32) , and increase of 2.3 times of hydrophobicity and 3.9 times of emulsifying activity. Obvious correlation showed the investigated factors were key points of emulsifying properties. Microscopic observation indicated glycosylated ovalbumin was prone to form small droplet of emulsion. 【Conclusion】 Emulsify properties were improved by glycosylation through change of surface charge and formation of amphiphilic structure.",
        "keywords": [
            "glycosylation",
            "emulsifying properties",
            "amphiphilic structure",
            "surface charge",
            "ovalbumin"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "Department of Food Science, Northeast Agricultural University, Harbin "
            },
            {
                "name": "CHI Yu-jie",
                "org": "Department of Food Science, Northeast Agricultural University, Harbin "
            }
        ],
        "venue": "Scientia Agricultura Sinica",
        "year": 2009
    },
    "JMOmSUta": {
        "id": "JMOmSUta",
        "title": "Preparation and Decolorization of Egg Yolk Lecithin",
        "abstract": "Extraction rate,product purity and color are key points to evaluate the extraction effects of egg yolk lecithin.In order to get egg yolk lecithin product with light color,good quality and high extraction rate,extraction of lecithin from phospholipo-protein powder was carried out with ethanol as solvent and active carbon as decolorant.The conditions for the egg lecithin extraction and decolorization were optimized.The obtained optimum conditions for the extraction are ratio of solid to liquid 1∶7(w/v),extraction time 40 min,extraction temperature 30 ℃ and ethanol concentration 95%.The optimum decoloring conditions are active carbon dose 4%,temperature 45 ℃ and time 60 min.Under these conditions,the lecithin content of the produced egg yolk lecithin is 95.26%,the extraction rate is 23.48 % and the decoloring rate is 96.47 %,with color of light yellow.",
        "keywords": [
            "egg yolk lecithin",
            "decolorant",
            "solvent extraction",
            "active carbon"
        ],
        "authors": [
            {
                "name": "Wang Yan",
                "org": "Food College,Northeast Agricultural University,Harbin "
            },
            {
                "name": "Chi Yujie",
                "org": "Food College,Northeast Agricultural University,Harbin "
            },
            {
                "name": "Yu Bin",
                "org": "Food College,Northeast Agricultural University,Harbin "
            }
        ],
        "venue": "Journal of the Chinese Cereals and Oils Association",
        "year": 2009
    },
    "x9ZLY1g5": {
        "id": "x9ZLY1g5",
        "title": "Effect of Extrinsic Factors on the Rheological Behavior of Egg White Protein",
        "abstract": "Egg white protein is used as ingredient in many food products for various functional properties.Response surface methodology(RSM) was used to evaluate extrinsic factors affecting the rheological behavior of egg white protein.Rheological parameters were determined over various treatment combinations ranging from 70.0 to 90.0 ℃,pH value 5.0 to 7.0,and NaCl concentrations of 0.02 to 0.08 mmol/L.Maximum hardness and springiness were measured at a treatment combination of 90 ℃,pH value 7.0,and 0.08 mmol/L NaCl.Gumminess was highest in gel with a treatment combination of 81.7 ℃,pH value 6.4,0.08 mmol/L.The result of study suggested that the temperature had the greatest effect on all three rheological parameters,gumminess and springiness were also affected by NaCl concentration,and pH only had influence on hardness.It is necessary to consider all the extrinsic factors for achievement of the desired rheological behavior.",
        "keywords": [
            "extrinsic factors",
            "egg white protein",
            "response surface methodology",
            "rheological behavior"
        ],
        "authors": [
            {
                "name": "CHI Yujie",
                "org": "Food College,Northeast Agricultural University,Harbin,Heilongjiang "
            },
            {
                "name": "YU Bin",
                "org": "Food College,Northeast Agricultural University,Harbin,Heilongjiang "
            }
        ],
        "venue": "China Poultry",
        "year": 2009
    },
    "x1xA7VFU": {
        "id": "x1xA7VFU",
        "title": "Research on Prepare Technology of High Vigor Egg White Lysozyme",
        "abstract": "Lysozyme has extensive uses in the pharmaceutical and food fields for it is a hydrolytic enzyme of high-saltine protein without toxicity or harmfulness. The study presented here was aimed at obtaining of high- activity lysozyme which was extracted by using cation exchange resin from egg white. The ratio of egg white and resin and stirring time in the adsorption were 5∶1 and 3.5 h respectively. Ionic strength of 1 mol/L and pH value of 8.0 were suitable to elution. Isoelectric precipitation and dialysis were carried out for further purification. Lysozyme with the activity of 20 650 U/mg and moisture content of 6.2% was obtained by spray-drying within input air temperature 110 ℃ and output air temperature 70 ℃.",
        "keywords": [
            "egg white",
            "spray-drying",
            "lysozyme",
            "cation exchange resin"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "Food College,Northeast Agricultural University,Harin ,China"
            },
            {
                "name": "Chi Yujie",
                "org": "Food College,Northeast Agricultural University,Harin ,China"
            }
        ],
        "venue": "Academic Periodical of Farm Products Processing",
        "year": 2006
    },
    "HieJTE9B": {
        "id": "HieJTE9B",
        "title": "Research on Functional Properties of Proteins Mixture by Simplex Lattice",
        "abstract": "Protein powder as food ingredient plays an important functional role in food processing,and there are obvious differences in functional properties and price among different protein powders.Simplex Lattice design was used to elucidate the functional properties of various combinations of soybean protein isolate,whey protein concentrate,egg white powder in this study.The results showed that foaming and emulsifying activity of whey protein concentrate,gelling properties and foaming stability of egg white powder,and emulsion stability of soy protein isolate played important role in functional properties of protein mixture.Synergistic effect was revealed on foaming,foaming stability and water holding capacity.The study suggested that the proteins mixture changed shortage of functional properties of single protein powder,reduced costs,and broaden the scope of application of protein powder.",
        "keywords": [
            "simplex lattice",
            "functional properties",
            "protein mixture"
        ],
        "authors": [
            {
                "name": "Yu Bin",
                "org": "College of Food Science,Northeast Agricultural University,Harbin ,China"
            },
            {
                "name": "Chi Yujie",
                "org": "College of Food Science,Northeast Agricultural University,Harbin ,China"
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2009
    },
    "g3GnzA85": {
        "id": "g3GnzA85",
        "title": "Influence of Deodorization Factors on Lipoxygenase Activity of Soybean Dietary Fibre",
        "abstract": "Soybean dietary fiber is found to have physiological effects to people,such as preventing constipation and lowering blood cholesterol or glucose level.Utilizing soybean dietary fiber as a human food additive has been encountered difficulty due to beany flavor which is originated from lipoxygenase activity,so it is necessary to remove beany flavor in soybean dietary fibre processing.The moist heat method was applied to remove beany flavor in this work;some parameters affecting the lipoxygenase activity including temperature and time were studied;and spectrophotometric analysis was adopted to determine the enzyme activity.Results show that the enzyme activity of lipoxygenase L-1 is 2.84 times as much as L-2 and 1.18 times as L-3.The enzyme activity is diminished with increasing temperature or extending time,whereas temperature is more effective to the enzyme activity than time.It is established that moist heat at 85 ℃ for 10 min is effective to decrease the lipoxygenase activity in soybean dietary fiber production.",
        "keywords": [
            "spectrophotometric analysis",
            "lipoxidase",
            "enzyme activity assay",
            "soybean dietary fiber"
        ],
        "authors": [
            {
                "name": "Sun Minjie",
                "org": "Food College,Northeast Agricultural University1,Harbin "
            },
            {
                "name": "Chi Yujie",
                "org": "Food College,Northeast Agricultural University1,Harbin ;Key laboratory of soybean biology in Chinese Ministry of Education2,Harbin "
            },
            {
                "name": "Yu Bin",
                "org": "Food College,Northeast Agricultural University1,Harbin "
            }
        ],
        "venue": "Journal of the Chinese Cereals and Oils Association",
        "year": 2008
    },
    "yRqlmxzj": {
        "id": "yRqlmxzj",
        "title": "Study on Affecting Factors of Egg White Protein Gel Property",
        "abstract": "Internal factors and external factors affecting the gel property of egg white protein were studied. The results indicated that the gel property of egg white protein was closely related to electrostatic interaction, hydrogen bond, disulfide bond, protein concentration, pH, heating temperature, heating time. These factors should be considered when the gel property of egg white protein is required.",
        "keywords": [
            "affecting factors",
            "egg white protein",
            "gel property"
        ],
        "authors": [
            {
                "name": "LI Li-xin",
                "org": "College of Food, Northeast Agricultural University, Harbin , China"
            },
            {
                "name": "CHI Yu-jie",
                "org": "College of Food, Northeast Agricultural University, Harbin , China"
            },
            {
                "name": "YU Bin",
                "org": "College of Food, Northeast Agricultural University, Harbin , China"
            }
        ],
        "venue": "Food Science",
        "year": 2008
    },
    "njci8n2e": {
        "id": "njci8n2e",
        "title": "Functional Improvement of Dried Egg White Glycosylation",
        "abstract": "The effects of glycosylation on the functional properties of dried egg white (DEW) were investigated in this study. Glycosylated DEW (G-DEW) was prepared by storing maltodextrin-DEW at 60 ℃ and 65% relative humidity for 0 to 5 days. Study of solubility of G-DEW showed little increase during early stages (0 to 3 days) and a significant decrease as glycosylation progressed beyond 4 days. Compared with unmodified sample,the G-DEW developed excellent heat stability,gelling,emulsibility,foaming properties. These results indicated that glycosylation could be used as an efficient method to improve functional properties of DEW.",
        "keywords": [
            "glycosylation",
            "egg white protein",
            "functional properties",
            "maltodextrin"
        ],
        "authors": [
            {
                "name": "YU Bin",
                "org": "College of Food,Northeast Agricultural University,Harbin,Heilongjiang "
            },
            {
                "name": "CHI Yujie",
                "org": "College of Food,Northeast Agricultural University,Harbin,Heilongjiang "
            }
        ],
        "venue": "China Poultry",
        "year": 2009
    },
    "GatwFToJ": {
        "id": "GatwFToJ",
        "title": "The Two-step Dipping Process of HMLS PET Cords",
        "abstract": "In this paper,the best pre-dipping time is found to be 120 s and the best RFL dipping time is 180 s based on the analysis of the relationship between dipping time and H-extraction force.Then,the two-step process for dipping PET cords is studied via the orthogonal test.The influence of technological parameters on the final adhesive performance is listed in descending order as follows: deblocking temperature>heat setting temperature>heat setting time>deblocking time>w(epoxy): w(water)(mass ratio).Meanwhile,variance analysis demonstrated that the deblocking temperature,heat setting temperature,and heat setting time had remarkable effects on adhesive properties.SEM images show that the glue adhered firmly to the surface of the PET after the two-step treatment,and the fracture during H-extraction can be attributed to typical cohesive failure.",
        "keywords": [
            "two-step process for dipping",
            "HMLS PET cords",
            "adhesion",
            "orthogonal test"
        ],
        "authors": [
            {
                "name": "LOU Qiao-hang",
                "org": "a.School of Materials and Textiles,b.The Key Laboratory of Advanced,,,, Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "HAN Jian",
                "org": "a.School of Materials and Textiles,b.The Key Laboratory of Advanced,,,, Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "DING Xin-bo",
                "org": "a.School of Materials and Textiles,b.The Key Laboratory of Advanced,,,, Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "XU Guo-ping",
                "org": "a.School of Materials and Textiles,b.The Key Laboratory of Advanced,,,, Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "a.School of Materials and Textiles,b.The Key Laboratory of Advanced,,,, Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2012
    },
    "8wAV47l9": {
        "id": "8wAV47l9",
        "title": "The Mechanical Properties of Polyester Filament for Warp-knitted Geo-grids",
        "abstract": "The crystal properties of polyester filament for warp-knitted Geo-grids were studied by DSC and dry heat shrink apparatus.The effect of temperature and time of heat treatment on performance of heat shrinkage,intensity,break elongation and fixup-elongation intensity are also studied.The results show that the temperature and time of heat treatment have little influence on the intensity of the polyester filament,but have evident influence on break elongation and fixup-elongation intensity.",
        "keywords": [
            "high strength polyester filament",
            "mechanical properties",
            "crystal properties"
        ],
        "authors": [
            {
                "name": "WANG Xiu-cheng",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "DING Xin-bo",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "HAN Jian",
                "org": "b.The Key Laboratory of Advanced Textile Materials andManufacturing Technology,Ministry of Education,Zhejiang Sci-Tech University,Hangzhou ,China"
            },
            {
                "name": "XU Guo-ping",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "YU Bin",
                "org": "a.School of Materials and Textiles,"
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2009
    },
    "W7mDJcif": {
        "id": "W7mDJcif",
        "title": "Preparation and Analysis of Polylactic Acid Resin Containing Tourmaline",
        "abstract": "A modified polylactic acid resin is made by adding different percentage tourmaline prepared,and the surface morphology,thermal properties,rheological behavior are tested by SEM,DSC,and Capillary Rheometer,respectively.The results show that the tourmaline exhibite an even distribution in the modified resin.The crystallinity of modified resin raises from 27% to 36%,and the melting point remain unchanged.With the rising of temperature,the apparent viscosity decreases and the non-Newtonian index increases.Besides,at the same temperature,the percentage of tourmaline increases,the apparent viscosity of the fluid decreases firstly and then increases with the increases of the tourmaline content.",
        "keywords": [
            "meltblowns",
            "polylactic acid",
            "tourmaline",
            "crystallinity",
            "apparent viscosity"
        ],
        "authors": [
            {
                "name": "ZHANG Qi",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "HAN Jian",
                "org": "The Key Laboratory of Advanced Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "XU Guo-ping",
                "org": ""
            },
            {
                "name": "DING Xin-bo",
                "org": ""
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2012
    },
    "4xhxyGyp": {
        "id": "4xhxyGyp",
        "title": "The Effect of Acid and Alkali on Mechanical Properties of PPS Fibers",
        "abstract": "PPS fibers are treated with four kinds of acids and alkali at different concentrations and time durations.The surface morphology of PPS fibers is studied by FESEM.Their tensile and thermal properties are measured by tensile tester and DSC,respectively.The results show that HCl and HNO3 have obviously detrimental effect on the properties of PPS fibers relative to NaOH and H2SO4.Many cracks and holes appeared on the surface of PPS fibers after HCl or HNO3 exposure.The breaking strength and breaking elongation of PPS fibers decrease as the increasing of concentrations and extension of time.Their melting heat is mostly affected by HNO3 among those acids and alkali.",
        "keywords": [
            "alkali treatment",
            "PPS fiber",
            "performance",
            "acid treatment"
        ],
        "authors": [
            {
                "name": "HE Xiang-bing",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "YU Bin",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "HAN Jian",
                "org": "a.School of Materials and Textiles,;b.The Key Lab.of Advanced Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "ZHANG Qi",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "XU Guo-ping",
                "org": "a.School of Materials and Textiles,"
            },
            {
                "name": "DING Xin-bo",
                "org": "a.School of Materials and Textiles,"
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2011
    },
    "aU88N8rn": {
        "id": "aU88N8rn",
        "title": "The influence of binder on structure and mechanical performance of spunlaced nonwovens",
        "abstract": "Basing on property test,the influence of various coated binder contents on apparent structure and pore distribution and thickness as well as permeability and mechnical performance were analyzed.The results show that by increasing of binder contents on spunlaced nonwovens,the nonwoven fibers each-entangle closely,pore size decreasing and pore distributing uniformly,tensile strength enhancing and elongation decreasing,the mass percentage of binder coated on spunlaced nonwovens being within 10% to 20%,the pore size distributing most uniformly and nonwovens being thinner with higher permeability,and when it being within 20% to 40%,the nonwovens could have excellent tensile strength and elongation.",
        "keywords": [
            "structure",
            "binder coating",
            "mechanical property",
            "spunlaced nonwovens"
        ],
        "authors": [
            {
                "name": "Wang Lu",
                "org": "Zhejiang Sci-Tech University"
            },
            {
                "name": "Yu Bin",
                "org": "Zhejiang Sci-Tech University"
            },
            {
                "name": "Zhu Chengyan",
                "org": "Zhejiang Sci-Tech University"
            },
            {
                "name": "Liu Beiren",
                "org": "Hangzhou Advanced Nonwoven Co.,Ltd.)"
            },
            {
                "name": "Shi Shubo",
                "org": "Zhejiang Sci-Tech University"
            }
        ],
        "venue": "Technical Textiles",
        "year": 2010
    },
    "keir7nAK": {
        "id": "keir7nAK",
        "title": "Influence of TiO_2 Particles on Rheological Property and Microstructure of PA6 Chips",
        "abstract": "The rheological behavior of the melt of PA6/TiO2 complex was tested by capillary rheometer, and the influence of TiO2 particles on microstructure of PA6 chips was studied by X-ray Diffractometer and TG. The results show that PA6/TiO2 complex belonged to the melt-shear-thinning fluid; their apparent viscosity became lower as the shear rate increased; their viscous flow activation energy was higher than that of pure PA6 fluid. Crystallinity and thermal stability were made no difference by TiO2 when contents of TiO2 particles were less; they were significantly improved, with a high level of contents of TiO2 particles.",
        "keywords": [
            "microstructure",
            "TiO2 particle",
            "PA6",
            "rheological property",
            "crystallinity"
        ],
        "authors": [
            {
                "name": "Han Jian",
                "org": "Key Laboratory of Advanced Textile Materials and Manufacturing Tech., Educational Ministry, Zhejiang Sci-Tech University, Hangzhou , China"
            },
            {
                "name": "Zhang Meifei",
                "org": "Key Laboratory of Advanced Textile Materials and Manufacturing Tech., Educational Ministry, Zhejiang Sci-Tech University, Hangzhou , China"
            },
            {
                "name": "Zhang Shunhua",
                "org": "Key Laboratory of Advanced Textile Materials and Manufacturing Tech., Educational Ministry, Zhejiang Sci-Tech University, Hangzhou , China"
            },
            {
                "name": "Ding Xinbo",
                "org": "Key Laboratory of Advanced Textile Materials and Manufacturing Tech., Educational Ministry, Zhejiang Sci-Tech University, Hangzhou , China"
            },
            {
                "name": "Yu Bin",
                "org": "Key Laboratory of Advanced Textile Materials and Manufacturing Tech., Educational Ministry, Zhejiang Sci-Tech University, Hangzhou , China"
            }
        ],
        "venue": "Rare Metal Materials and Engineering",
        "year": 2010
    },
    "3jaIS3UO": {
        "id": "3jaIS3UO",
        "title": "Effect of Pore Structure of Differential Linear Density on Filtration Performance of Spunlaced Nonwovens",
        "abstract": "Nonwovens made of fiber of various thickness are prepared through the method of spunlace.The apparent structure,pore size distribution and porosity are analyzed,furthermore,filtration performance of the spulanced nonwovens is discussed.The results show that porosity of the spulanced nonwovens is increased and the filtration performance is improved because of the pore structure of differential linear density,however,the effect on pore size distribution is unobvious.Moreover,the air permeability is positively correlated with the porosity while the filtration efficiency is negatively correlated with the average pore size.",
        "keywords": [
            "pore structure",
            "air permeability",
            "differential linear density",
            "nonwovens",
            "filtration efficiency"
        ],
        "authors": [
            {
                "name": "WANG Lu",
                "org": "1.The Key Laboratory of Advanced Textile Materials and Manufacturing Technology(Zhejiang Sci-Tech University"
            },
            {
                "name": "YU Bin",
                "org": "1.The Key Laboratory of Advanced Textile Materials and Manufacturing Technology(Zhejiang Sci-Tech University"
            },
            {
                "name": "ZHU Cheng-yan",
                "org": "1.The Key Laboratory of Advanced Textile Materials and Manufacturing Technology(Zhejiang Sci-Tech University"
            },
            {
                "name": "SHI Shu-bo",
                "org": ""
            },
            {
                "name": "LIU Bei-ren",
                "org": ""
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2010
    },
    "uSRvOnec": {
        "id": "uSRvOnec",
        "title": "The influence of drawing pressure on the properties of PET/PA6 bicomponent spunbonded fibers",
        "abstract": "The properties of fibers were significantly affected by drawing during the spunbond process. In this paper, the influence of drawing pressure on the properties of spun-bonded PET/PA6 hollow pie wedge bicomponent filaments was studied, and their performance was characterized by differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, Beion F6 fiber fineness tester, and single fiber strength tester. The hollow pie wedge bicomponent fiber had a distinct interface between the two polymers due to poor compatibility. With increasing of drawing pressure, diameter of the fibers reduced regularly. When the drawing pressure increased, both the degree of crystallinity and orientation of bicomponent fibers enhanced, and the melting point of polyester component increased as well. Furthermore, with increasing of drawing pressure, the breaking strength of the fibers increased, but the breaking elongation and linear density decreased.",
        "keywords": [
            "Drawing pressure",
            "PET/PA6 bicomponent fiber",
            "orientation",
            "spunbond"
        ],
        "authors": [
            {
                "name": "min wang",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "bin yu",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "jian han",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "weimin song",
                "org": "Langfang Chinatex Xinyuan Nonwovens Co LTD, Langfang, Hebei, Peoples R China"
            },
            {
                "name": "feichao zhu",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF INDUSTRIAL TEXTILES",
        "year": 2017
    },
    "BkiWEQnE": {
        "id": "BkiWEQnE",
        "title": "Study on the Thermal Stability and Surface Morphology of PVC Membrane Structure Materials",
        "abstract": "PVC membrane structure materials are prepared with the solution blending method,and the effect of DINP,Ba-Zn and CaCO3 particles on the properties of coatings is studied by TG,DSC,SEM and dynamic light scattering particle size analyzer.The experimental results indicated that the viscosity of PVC membranes can reduce by adding DINP.Their thermal stability can be improved by Ba-Zn;The agglomeration of ultrafine CaCO3/ethanol blends are reduced by using ultrasonic method;When superfine heavy CaCO3 particles are added into the PVC membranes,the roughness of their surface is better,comparing to ultrafine CaCO3 particles.",
        "keywords": [
            "TG",
            "viscosity",
            "MI",
            "PVC membrane structure material",
            "DSC"
        ],
        "authors": [
            {
                "name": "LI Ming-liang",
                "org": ""
            },
            {
                "name": "DING Xin-bo",
                "org": ""
            },
            {
                "name": "HAN Jian",
                "org": "The Key Laboratory of Advanced Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "XU Guo-ping",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2011
    },
    "CdaTuDE5": {
        "id": "CdaTuDE5",
        "title": "Controllability of Particle Size of Nano SiO_2 for PVC Architectural Membrane Material",
        "abstract": "To develop nano SiO2 powder for PVC architectural membrane material,this study prepares the powder with sol-gel method and uses organic-inorganic hybridization method for modification so as to reduce the hydrophily of the powder.The analysis of laser particle size instrument shows that the particle size of silica increases with the increase of n(NH3·H2O)∶n(TEOS) molar ratio.Thermogravimetric analysis shows that,with the increase of n(NH3·H2O)∶n(TEOS) molar ratio,hydroxyl content first increases and then decreases and reaches the peak value when the molar ratio is 1∶1.Infrared analysis shows that silane coupling agent KH-570 and nano SiO2 powder react.Hydroxyl group is introduced and meanwhile the number of hydroxyl decreases.",
        "keywords": [
            "silane coupling agent",
            "particle size",
            "hydroxyl content",
            "SiO2",
            "sol-gel method"
        ],
        "authors": [
            {
                "name": "ZHANG Chun-shan",
                "org": "School of Materials and Textiles"
            },
            {
                "name": "DING Xin-bo",
                "org": "School of Materials and Textiles"
            },
            {
                "name": "HAN Jian",
                "org": "School of Materials and Textiles;Key Laboratory of Advanced Textile Materials and ManufacturingTechnology,Ministry of Education,Zhejiang Sci-Tech University,Hangzhou ,China"
            },
            {
                "name": "YU Bin",
                "org": "School of Materials and Textiles"
            },
            {
                "name": "XU Guo-ping",
                "org": "School of Materials and Textiles"
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2013
    },
    "EFWLVgwa": {
        "id": "EFWLVgwa",
        "title": "Study on Influence of Flame-retardant Plasticizer on Flame Retardation",
        "abstract": "This study plastifies PVC resin by using flame-retardant plasticizer diphenyl benzyl phosphate(DPK)and normal plasticizer DINP with different proportions and makes the corresponding coating material for PVC building membrane materials;investigates their effect for flame retardation and processing performance of the material;studies the influence of DPK on thermal degradation process of PVC material with thermogravimetric analysis method;uses scanning electron microscope to observe the morphology of carbon residue of the material and analyzes the flame-retardant mechanism of DPK.The result shows that flame-retardant plasticizer DPK can promote PVC gas dehydrochlorination and form a dense carbonization membrane on the surface of the material and has excellent flame retardation.In complex use w(DPK)∶w(DINP)=10∶50,it can effectively improve the flame retardation and workability of PVC coating material.",
        "keywords": [
            "PVC materials",
            "flame retardation",
            "viscosity",
            "flame-retardant plasticizer"
        ],
        "authors": [
            {
                "name": "KANG Mi",
                "org": ""
            },
            {
                "name": "HAN Jian",
                "org": ""
            },
            {
                "name": "DING Xin-bo",
                "org": ""
            },
            {
                "name": "Xu Guo-ping",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            },
            {
                "name": "Xu Chang-ya",
                "org": ""
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2013
    },
    "FIBelf3C": {
        "id": "FIBelf3C",
        "title": "The Influence of Process Factors on the Mechanical Properties of Flexible Composite Materials",
        "abstract": "The quadratic general rotary unitized design of three factors,the temperature,the pressure and the time,is used to study the influence of process factors on the mechanical properties of flexible composite materials.The tensile property and peeling performance are tested,and the mathematical models about breaking force,elongation at break and peel strength are built.The results show that temperature is the most significant factor influencing the mechanical properties of flexible composites,and the optimal condition of process factors are as follows:the temperature is 165℃,the pressure is 3 MPa,and the time is 160 s.",
        "keywords": [
            "flexing composite materials",
            "regression design",
            "mechanical property",
            "compound process"
        ],
        "authors": [
            {
                "name": "ZHOU Yang",
                "org": ""
            },
            {
                "name": "DING Xin-bo",
                "org": ""
            },
            {
                "name": "HAN Jian",
                "org": "The Key Laboratory of Advanced Textile Materials and Manufacturing Technology,Ministry of Education,Hangzhou ,China"
            },
            {
                "name": "XU Guo-ping",
                "org": ""
            },
            {
                "name": "YU Bin",
                "org": ""
            }
        ],
        "venue": "Journal of Zhejiang Sci-Tech University",
        "year": 2012
    },
    "AaJCskAk": {
        "id": "AaJCskAk",
        "title": "Research on high temperature resistance air filter media",
        "abstract": "The development status and the characteristics of high temperature resistance air filter media were introduced. The performances and research situation of novel filter media made of various materials,such as glass fiber,aramid fiber,PTFE membrane,P84 and PPS were summarized. The development trend of high temperature resistance filter media was also discussed in the paper.",
        "keywords": [
            "performance",
            "present situation of research",
            "development trend",
            "high temperature resistance air filter media"
        ],
        "authors": [
            {
                "name": "Wang Lu",
                "org": " Zhejiang Sci-Tech University"
            },
            {
                "name": "Yu Bin",
                "org": " Zhejiang Sci-Tech University"
            },
            {
                "name": "Zhu Chengyan",
                "org": " Zhejiang Sci-Tech University"
            },
            {
                "name": "Shi Shubo",
                "org": " Hangzhou Advanced Nonwoven Co. ,Ltd."
            },
            {
                "name": "Liu Beiren",
                "org": " Hangzhou Advanced Nonwoven Co. ,Ltd."
            }
        ],
        "venue": "Technical Textiles",
        "year": 2010
    },
    "JuGsqZCi": {
        "id": "JuGsqZCi",
        "title": "High performance sub-50 nm CMOS with advanced gate stack",
        "abstract": "",
        "keywords": [
            "gate dielectric",
            "temperature",
            "boron",
            "cmos integrated circuits",
            "fabrication",
            "contact resistance",
            "transistors",
            "reliability",
            "cmos technology",
            "equivalent oxide thickness"
        ],
        "authors": [
            {
                "name": "qi xiang",
                "org": "advanced micro devices"
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "dWrrPQsg": {
        "id": "dWrrPQsg",
        "title": "SOI device with metal source/drain and method of fabrication",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zoran krivokapic",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "G2RJrJ00": {
        "id": "G2RJrJ00",
        "title": "Integrated circuit having transistors with different threshold voltages",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 1998
    },
    "AOAW5XXW": {
        "id": "AOAW5XXW",
        "title": "Double gate semiconductor device having separate gates",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
    "GoZ8m44O": {
        "id": "GoZ8m44O",
        "title": "Polysilicon tilting to prevent geometry effects during laser thermal annealing",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "eric n paton",
                "org": ""
            },
            {
                "name": "robert b ogle",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2005
    },
    "1buJGQyb": {
        "id": "1buJGQyb",
        "title": "Narrow body raised source/drain metal gate MOSFET",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2006
    },
    "0UEuL58E": {
        "id": "0UEuL58E",
        "title": "Uniformly doped source/drain junction in a double-gate MOSFET",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
    "pBzdObpp": {
        "id": "pBzdObpp",
        "title": "Reversed T-shaped FinFET",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "iSK0hYOj": {
        "id": "iSK0hYOj",
        "title": "Method of fabricating an integrated circuit with ultra-shallow source/drain extensions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "GVUXuZO2": {
        "id": "GVUXuZO2",
        "title": "Method of manufacturing a semiconductor device having a fin structure",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "srikanteswara dakshinamurthy",
                "org": ""
            },
            {
                "name": "zoran krivokapic",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "x4VHuPF8": {
        "id": "x4VHuPF8",
        "title": "MOS transistor with stepped gate insulator",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "NZq2rxI4": {
        "id": "NZq2rxI4",
        "title": "Narrow fin FinFET",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zoran krivokapic",
                "org": ""
            },
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "srikanteswara dakshinamurthy",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "feRAfL3S": {
        "id": "feRAfL3S",
        "title": "Multi-step chemical mechanical polishing of a gate area in a FinFET",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "krishnashree achuthan",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2006
    },
    "Omnm6MGv": {
        "id": "Omnm6MGv",
        "title": "Source and drain protection and stringer-free gate formation in semiconductor devices",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chihyuh yang",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "srikanteswara dakshinamurhty",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
    "Yxk4vPa6": {
        "id": "Yxk4vPa6",
        "title": "Verfahren zur Herstellung eines Steg-Feldeffekttransistors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "MuDSdHAz": {
        "id": "MuDSdHAz",
        "title": "Narrow width CMOS devices fabricated on strained lattice semiconductor substrates with maximized NMOS and PMOS drive currents",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "daniel kadosh",
                "org": ""
            },
            {
                "name": "derick j wristers",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "kYqtsALT": {
        "id": "kYqtsALT",
        "title": "Method of manufacturing a transistor with local insulator structure",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            },
            {
                "name": "shekhar pramanick",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "32uvmNi2": {
        "id": "32uvmNi2",
        "title": "Method for forming a fin in a finFET device",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chihyuh yang",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "srikanteswara dakshinamurthy",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "EfcvfDAL": {
        "id": "EfcvfDAL",
        "title": "Method for forming multiple structures in a semiconductor device",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "McRMBqvg": {
        "id": "McRMBqvg",
        "title": "Method for forming fins in a FinFET device using sacrificial carbon layer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "matthew s buynoski",
                "org": ""
            },
            {
                "name": "srikanteswara dakshinamurthy",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "chihyuh yang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "oHD1EUm4": {
        "id": "oHD1EUm4",
        "title": "Semiconductor device and fabrication technique using a high-K liner for spacer etch stop",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "olov karlsson",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
    "yeOJcHmn": {
        "id": "yeOJcHmn",
        "title": "MOSFETs with differing gate dielectrics and method of formation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "olov karlsson",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "zoran krivokapic",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
    "aVBEK8hx": {
        "id": "aVBEK8hx",
        "title": "Planarizing gate material to improve gate critical dimension in semiconductor devices",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "3zIzLjS7": {
        "id": "3zIzLjS7",
        "title": "MOS transistor with low-k spacer to suppress capacitive coupling between gate and source/drain extensions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "yowjuang w liu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2000
    },
    "0itSGdCF": {
        "id": "0itSGdCF",
        "title": "Method of manufacturing a dual doped CMOS gate",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "v5c7I7r1": {
        "id": "v5c7I7r1",
        "title": "Self aligned damascene gate",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "matthew s buynoski",
                "org": ""
            },
            {
                "name": "srikanteswara dakshinamurthy",
                "org": ""
            },
            {
                "name": "zoran krivokapic",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "chihyuh yang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2006
    },
    "2NfKnfQA": {
        "id": "2NfKnfQA",
        "title": "Method for forming a gate in a FinFET device and thinning a fin in a channel region of the FinFET device",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "KpKJAqdQ": {
        "id": "KpKJAqdQ",
        "title": "Damascene gate semiconductor processing with local thinning of channel region",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2005
    },
    "6xJjyBZu": {
        "id": "6xJjyBZu",
        "title": "Low nisi/si interface contact resistance with preamorphizing and laser thermal annealing",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "robert b ogle",
                "org": ""
            },
            {
                "name": "eric n paton",
                "org": ""
            },
            {
                "name": "cyrus e tabery",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "I6yLkyJ5": {
        "id": "I6yLkyJ5",
        "title": "Process for manufacturing MOS transistors having elevated source and drain regions and a high-k gate dielectric",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "t2a1729W": {
        "id": "t2a1729W",
        "title": "Method of locally forming a silicon/geranium channel layer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "AMfFeAf2": {
        "id": "AMfFeAf2",
        "title": "Strained-silicon devices with different silicon thicknesses",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "james f buller",
                "org": ""
            },
            {
                "name": "derick j wristers",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "CupT0THV": {
        "id": "CupT0THV",
        "title": "MOS transistor with high-K spacer designed for ultra-large-scale integration",
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                "name": "bin yu",
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            {
                "name": "shibly s ahmed",
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                "name": "bin yu",
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            {
                "name": "bin yu",
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            {
                "name": "emi ishida",
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        "id": "Ud0kfMPX",
        "title": "Integrated circuit having isolation structures",
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            {
                "name": "bin yu",
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            {
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        "id": "hNIazAWK",
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            {
                "name": "wiley eugene hill",
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            {
                "name": "mingren lin",
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            {
                "name": "bin yu",
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                "name": "qi xiang",
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            {
                "name": "mingren lin",
                "org": "advanced micro devices"
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        "title": "Semiconductor-on-insulator (SOI) wafer having a Si/SiGe/Si active layer and method of fabrication using wafer bonding",
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        "authors": [
            {
                "name": "bin yu",
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            {
                "name": "william g en",
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            {
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            {
                "name": "concetta e riccobene",
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        "authors": [
            {
                "name": "bin yu",
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            {
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        "id": "a1EHdT4z",
        "title": "Narrow-body damascene tri-gate FinFET",
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        "authors": [
            {
                "name": "shibly s ahmed",
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            {
                "name": "haihong wang",
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            {
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        ],
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        "id": "kRf0I4Xa",
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            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "haihong wang",
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        ],
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    "bOetBCA8": {
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            {
                "name": "qi xiang",
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            {
                "name": "bin yu",
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        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
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            {
                "name": "haihong wang",
                "org": ""
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        ],
        "venue": "",
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        "id": "BHTDYKaH",
        "title": "Semiconductor device having a thin fin and raised source/drain areas",
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        "authors": [
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "judy xilin an",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2005
    },
    "2PyxqSWh": {
        "id": "2PyxqSWh",
        "title": "Effects of indium implant and post-RTA on performance and reliability of sub-100-nm retrograde channel NMOSFETs",
        "abstract": "",
        "keywords": [
            "leakage current",
            "indium",
            "boron",
            "doping",
            "stress testing",
            "reliability"
        ],
        "authors": [
            {
                "name": "qi xiang",
                "org": "advanced micro devices"
            },
            {
                "name": "bin yu",
                "org": "advanced micro devices"
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            {
                "name": "g yeap",
                "org": "motorola"
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            {
                "name": "mingren lin",
                "org": "advanced micro devices"
            }
        ],
        "venue": "",
        "year": 1999
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        "id": "Rzs5fIRa",
        "title": "Nanoscale CMOS at low temperature: design, reliability, and scaling trend",
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            "design",
            "nanotechnology",
            "cmos technology",
            "reliability",
            "chip",
            "hot carriers",
            "scaling limit",
            "room temperature",
            "degradation",
            "electron mobility",
            "cmos integrated circuits",
            "impact ionization",
            "integrated circuit design"
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        "authors": [
            {
                "name": "bin yu",
                "org": "advanced micro devices"
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "concetta e riccobene",
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            {
                "name": "hyeonseag kim",
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            {
                "name": "qi xiang",
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            {
                "name": "mingren lin",
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            },
            {
                "name": "leland chang",
                "org": ""
            },
            {
                "name": "chenming hu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
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        "id": "8Eu5GOne",
        "title": "SRAM formation using shadow implantation",
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            {
                "name": "wiley eugene hill",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
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        ],
        "venue": "",
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        "id": "HCrogw7X",
        "title": "Dual silicon layer for chemical mechanical polishing planarization",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "krishnashree achuthan",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
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            {
                "name": "haihong wang",
                "org": ""
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            {
                "name": "bin yu",
                "org": ""
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        ],
        "venue": "",
        "year": 2004
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        "id": "oMNiWBHm",
        "title": "Process for forming multiple active lines and gate-all-around MOSFET",
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        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2000
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        "id": "kNn5XIlR",
        "title": "Damascene tri-gate FinFET",
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        "authors": [
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
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            {
                "name": "bin yu",
                "org": ""
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        "title": "Double spacer FinFET formation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "matthew s buynoski",
                "org": ""
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            {
                "name": "judy xilin an",
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            {
                "name": "haihong wang",
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            {
                "name": "bin yu",
                "org": ""
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        ],
        "venue": "",
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        "title": "Damascene process for forming ultra-shallow source/drain extensions and pocket in ULSI MOSFET",
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        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "judy xilin an",
                "org": ""
            }
        ],
        "venue": "",
        "year": 1999
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        "id": "sP0LLUaO",
        "title": "FULLY SILICIDED GATE STRUCTURE FOR FINFET DEVICES",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mingren lin",
                "org": ""
            },
            {
                "name": "witold p maszara",
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            {
                "name": "haihong wang",
                "org": ""
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            {
                "name": "bin yu",
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        "id": "ijnIZDWZ",
        "title": "Deep sub-100 nm CMOS with ultra low gate sheet resistance by NiSi",
        "abstract": "CMOS devices down to 50 nm gate length were fabricated with NiSi salicide for the first time. Edge effects of Ni-polycide formation, enhanced by a recessed spacer, results in gate Rs roll-off with poly line width. Ultra low /spl sim/2 /spl Omega///spl square/ gate Rs is achieved for 50 nm line width with low junction leakage. Source/drain series resistance is significantly reduced and, consequently, drive current is improved with NiSi. Ring oscillator speed measurements showed significant improvement in gate delay with NiSi, especially for the ring oscillators made with large gate width devices.",
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            "temperature",
            "edge effect",
            "diodes",
            "contact resistance",
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            "series resistance"
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        "authors": [
            {
                "name": "qi xiang",
                "org": "advanced micro devices"
            },
            {
                "name": "christy woo",
                "org": ""
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            {
                "name": "eric n paton",
                "org": ""
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            {
                "name": "j m foster",
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            {
                "name": "bin yu",
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            {
                "name": "mingren lin",
                "org": ""
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        "venue": "Honolulu, HI, USA",
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        "keywords": [
            "nanotechnology",
            "scaling limit",
            "dielectrics",
            "tunneling",
            "leakage current",
            "scattering",
            "degradation",
            "carrier mobility"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": "advanced micro devices"
            },
            {
                "name": "haihong wang",
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            },
            {
                "name": "concetta e riccobene",
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            {
                "name": "qi xiang",
                "org": ""
            },
            {
                "name": "mingren lin",
                "org": ""
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        ],
        "venue": "",
        "year": 2000
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        "id": "Lhon68rX",
        "title": "Epitaxially grown fin for FinFET",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "srikanteswara dakshinamurthy",
                "org": ""
            },
            {
                "name": "chihyuh yang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
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        "id": "QPlVbn5S",
        "title": "Ultra-thin body SOI MOSFET and gate-last fabrication method",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
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        "id": "5jL1voLB",
        "title": "Damascene gate process with sacrificial oxide in semiconductor devices",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
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        "id": "idkdz0J1",
        "title": "MOSFET device having high-K dielectric layer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2003
    },
    "zWyAojup": {
        "id": "zWyAojup",
        "title": "Variieren der Ladungsträgerbeweglichkeit in Halb-Leiterbauelementen, um Gesamtentwurfsziele zu erreichen",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "shibly s ahmed",
                "org": ""
            },
            {
                "name": "haihong wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2006
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    "W1tZ61E9": {
        "id": "W1tZ61E9",
        "title": "MOS-gate tunneling-injection bipolar transistor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "BoQNOFbU": {
        "id": "BoQNOFbU",
        "title": "Formation of well-controlled thin SiO, SiN, SiON layer for multilayer high-K dielectric applications",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "eric n paton",
                "org": ""
            },
            {
                "name": "qi xiang",
                "org": ""
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        "id": "MjfmIXQ6",
        "title": "Power control method, base station and terminal for physical uplink control channel",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "weiwei yang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "2fcPNosi": {
        "id": "2fcPNosi",
        "title": "System and Method for Signaling Configuration of Sounding Reference Signals",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yuxin wang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "weiwei yang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "Tr41cia2": {
        "id": "Tr41cia2",
        "title": "METHOD AND APPARATUS FOR TRANSMITTING REFERENCE SIGNAL",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "yuqiang zhang",
                "org": ""
            },
            {
                "name": "yuxin wang",
                "org": ""
            },
            {
                "name": "rong zhang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "i3asg0sR": {
        "id": "i3asg0sR",
        "title": "Service bearing method and apparatus, service data receiving method and receiving terminal",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "zijiang ma",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "6yZtGDJj": {
        "id": "6yZtGDJj",
        "title": "Method for configuring and indicating physical random access channel PRACH parameters in a time division duplex system",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "dKvN3ifm": {
        "id": "dKvN3ifm",
        "title": "METHOD FOR ALLOCATING PHYSICAL HYBRID ARQ INDICATOR CHANNELS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "OvH4ZFLA": {
        "id": "OvH4ZFLA",
        "title": "Transmitting methods of a signal on a random access channel in a wireless communication system",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "CT4YcnFf": {
        "id": "CT4YcnFf",
        "title": "Inter-node B handover method",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yin gao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "peng zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "TIKNbIdH": {
        "id": "TIKNbIdH",
        "title": "METHOD AND APPARATUS FOR TRANSMITTING HYBRID AUTOMATIC REPEAT REQUEST ACKNOWLEDGE INFORMATION",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiwei yang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "ssnHrRGW": {
        "id": "ssnHrRGW",
        "title": "NON-ORTHOGONAL COMMUNICATION METHOD IN WIRELESS COMMUNICATION SYSTEM, AND eNB AND USER EQUIPMENT THEREOF",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pengfei sun",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "chengjun sun",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "sRYAvK6Y": {
        "id": "sRYAvK6Y",
        "title": "Method and System for Signaling Configuration of Physical Uplink Shared Channel",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yuxin wang",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "peng zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "4PQ6Eor5": {
        "id": "4PQ6Eor5",
        "title": "Method for Reporting Channel State Information and Base Station",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "5vcmg1zU": {
        "id": "5vcmg1zU",
        "title": "Method and Base Station for Sending Uplink Scheduling Grant Control Signaling",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "yuqiang zhang",
                "org": ""
            },
            {
                "name": "yuxin wang",
                "org": ""
            },
            {
                "name": "bo jin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "SF2pDq7p": {
        "id": "SF2pDq7p",
        "title": "Method and terminal for transmitting uplink control information and method and apparatus for determining the number of coded symbol",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiwei yang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "VoTcxIRC": {
        "id": "VoTcxIRC",
        "title": "Method and User Equipment for Transmitting Feedback Information",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "LBilxHdm": {
        "id": "LBilxHdm",
        "title": "Altered carbon assimilation and cellulose accessibility to maximize bioethanol yield under low-cost biomass processing in corn brittle stalk",
        "abstract": "Although cellulosic ethanol has been regarded as an ideal additive for transportation fuels, its low accessibility from recalcitrant lignocellulose renders the bioethanol process unacceptably expensive for commercial production. Here, this study collected the brittle stalk of a corn mutant, bk1, that showed similar biomass and seed yields to its wild type (elite cultivar). We then detected significantly reduced cellulose content and degree of polymerization of beta-1,4-glucans, leading to a 74% increase in directly-fermentable hexoses accumulation in the brittle stalk by reducing sucrose production and altering carbon assimilation. Notably, under two green-like pretreatments (20 min liquid hot water, 15% CaO at 50 degrees C), the brittle stalk exhibited remarkably improved cellulose accessibility for almost complete biomass saccharification. This resulted in achieving the highest bioethanol yield of 19.3% (% dry matter) to date, outperforming previous efforts that relied on harsh corn stalk pretreatments. Furthermore, even without any pretreatment, we evaluated that the brittle stalk could deliver a bioethanol yield of 20.3% if the total xylose and hexoses from the brittle stalk were combined for yeast co-fermentation. This study has thus provided a prospective new model for the green-like bioethanol industry that integrates engineered bioenergy crops and yeast strains with cost-effective biomass processing.",
        "keywords": "",
        "authors": [
            {
                "name": "Leiming Wu",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Shengqiu Feng",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Jun Deng",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Youmei Wang",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Boyang He",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Hao Peng",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Qian Li",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Ruofei Hu",
                "org": "Hubei Univ Arts & Sci, Coll Food Sci & Technol, Xiangyang 441053, Peoples R China"
            },
            {
                "name": "Liangcai Peng",
                "org": "Huazhong Agr Univ, Biomass & Bioenergy Res Ctr, Wuhan, Hubei, Peoples R China"
            }
        ],
        "venue": "GREEN CHEMISTRY",
        "year": 2019
    },
    "dre6emAE": {
        "id": "dre6emAE",
        "title": "Procédé et dispositif de configuration d'agrégation de porteuses",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "喻斌",
                "org": ""
            },
            {
                "name": "戴博",
                "org": ""
            },
            {
                "name": "郝鹏",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "GSZlOyWa": {
        "id": "GSZlOyWa",
        "title": "Sounding reference signal transmission method and apparatus in carrier aggregation scenario",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "rong zhang",
                "org": ""
            },
            {
                "name": "张戎",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "郝鹏",
                "org": ""
            },
            {
                "name": "yuqiang zhang",
                "org": ""
            },
            {
                "name": "张禹强",
                "org": ""
            },
            {
                "name": "yuxin wang",
                "org": ""
            },
            {
                "name": "王瑜新",
                "org": ""
            },
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "朱鹏",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "喻斌",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "PoCK4jIg": {
        "id": "PoCK4jIg",
        "title": "Method and device for reducing transmission power of uplink signal",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhirong lin",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "lu ren",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "OifiQhjz": {
        "id": "OifiQhjz",
        "title": "METHOD FOR SENDING A SOUNDING REFERENCE SIGNAL OF UPLINK CHANNEL IN A TIME DIVISION DUPLEX SYSTEM",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "8SnmEsCr": {
        "id": "8SnmEsCr",
        "title": "METHOD FOR SENDING THE PHYSICAL BROADCAST CHANNEL IN A TIME DIVISION DUPLEX SYSTEM",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "guanghui yu",
                "org": ""
            },
            {
                "name": "liujun hu",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "JdnBSdnz": {
        "id": "JdnBSdnz",
        "title": "Method and system for transmitting physical random access channel",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xin wu",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "HlqVJ9VR": {
        "id": "HlqVJ9VR",
        "title": "Terminal random access method for cellular radio communications system and method for generating group identifier",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhongda du",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "junfeng zhang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "P03buYcS": {
        "id": "P03buYcS",
        "title": "METHOD AND BASE STATION FOR ALLOCATING DEDICATED RANDOM ACCESS RESOURCE",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "zhongda du",
                "org": ""
            },
            {
                "name": "kexue lu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "VXN2TgRG": {
        "id": "VXN2TgRG",
        "title": "Method and Apparatus for Sequencing ZC Sequences of a Random Access Channel",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "rrUbGz7M": {
        "id": "rrUbGz7M",
        "title": "Base Station, Terminal, System And Method For Data Transmitting In Time-Division Duplex System",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "1wYbW1D8": {
        "id": "1wYbW1D8",
        "title": "RADIO FRAME AND SOUNDING REFERENCE SIGNAL SENDING METHOD IN MOBILE COMMUNICATION SYSTEM",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "yuxin wang",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "Hnxl8cNY": {
        "id": "Hnxl8cNY",
        "title": "A Method for generating the group identifier of the random access response message, and a random access method",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhongda du",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "AGTwEaKD": {
        "id": "AGTwEaKD",
        "title": "CONFIGURATION METHOD AND SYSTEM FOR SOUNDING REFERENCE SIGNAL IN LONG TERM EVOLUTION-ADVANCED SYSTEM",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "VwHOb1Ym": {
        "id": "VwHOb1Ym",
        "title": "Power control method and device for physical uplink control channel",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "xin wu",
                "org": ""
            },
            {
                "name": "weiwei yang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "吴欣",
                "org": ""
            },
            {
                "name": "喻斌",
                "org": ""
            },
            {
                "name": "戴博",
                "org": ""
            },
            {
                "name": "杨维维",
                "org": ""
            },
            {
                "name": "梁春丽",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "5AW7jDVM": {
        "id": "5AW7jDVM",
        "title": "Method and base station for triggering aperiodic channel state information report",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "weiwei yang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "peng zhu",
                "org": ""
            },
            {
                "name": "喻斌",
                "org": ""
            },
            {
                "name": "戴博",
                "org": ""
            },
            {
                "name": "朱鹏",
                "org": ""
            },
            {
                "name": "杨维维",
                "org": ""
            },
            {
                "name": "梁春丽",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "mC4nrsWi": {
        "id": "mC4nrsWi",
        "title": "Method and System for Processing an Uplink Control Signaling Feedback",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "weiwei yang",
                "org": ""
            },
            {
                "name": "peng zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "rzlf8IH4": {
        "id": "rzlf8IH4",
        "title": "METHOD FOR MAPPING PHYSICAL RANDOM ACCESS CHANNELS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "q0wKrLtr": {
        "id": "q0wKrLtr",
        "title": "Method for Determining Random Access Channel Number and Sending Sounding Reference Signal",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "74iwLX2U": {
        "id": "74iwLX2U",
        "title": "System and a method for indicating an uplink resource",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            },
            {
                "name": "peng hao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "ayOk9nWC": {
        "id": "ayOk9nWC",
        "title": "Physical uplink control channel power control method and apparatus",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiwei yang",
                "org": ""
            },
            {
                "name": "xin wu",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "No3TvO3w": {
        "id": "No3TvO3w",
        "title": "Method for generation of cyclic shift amount set and method for generation of random access preamble",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng hao",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "shuqiang xia",
                "org": ""
            },
            {
                "name": "bo dai",
                "org": ""
            },
            {
                "name": "chunli liang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "kzp8cJSZ": {
        "id": "kzp8cJSZ",
        "title": "Microstructure, Thermal Properties and Rheological Behavior of PLA/PCL Blends for Melt-blown Nonwovens",
        "abstract": "",
        "keywords": [
            "microstructure"
        ],
        "authors": [
            {
                "name": "hui sun",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "jan han",
                "org": ""
            },
            {
                "name": "jinjin kong",
                "org": ""
            },
            {
                "name": "lingrui meng",
                "org": ""
            },
            {
                "name": "feichao zhu",
                "org": ""
            }
        ],
        "venue": "Polymer-korea",
        "year": 2014
    },
    "ZDZhHxq4": {
        "id": "ZDZhHxq4",
        "title": "Study on dual-monomer melt-grafted poly(lactic acid) compatibilized poly(lactic acid)/polyamide 11 blends and toughened melt-blown nonwovens",
        "abstract": "With increasing demands on the high-performance and environmental-friendly melt-blown nonwovens (MBs) for separation and filtration, herein, we reported a poly(lactic acid)/polyamide 11 (PLA/PA11) 100% bio-based MBs in situ compatibilized by dual-monomer glycidyl methacrylate-styrene melt-grafted poly(lactic acid) (PLA-g-(St-co-GMA)). The morphology, crystallization, thermal and rheological behaviors of reactive extruded PLA/PA11/PLA-g-(St-co-GMA) melt blends were investigated, and the structure and filtration performance of corresponding MBs were fully characterized. The results indicated that the interface between PLA and PA11 were effectively improved due to the compatibilizer of PLA-g-(St-co-GMA). PA11 promoted the cold crystallization and enhanced the thermal stability of PLA matrix. The reactive blends displayed a higher viscosity with unchanged rheological behaviors compared with PLA. In comparison with PLA MBs, the average fiber diameter and pore size of PLA/PA11/PLA-g-(St-co-GMA) MBs were slightly increased, whereas the strength and toughness were significantly improved. All the PLA/PA11/PLA-g-(St-co-GMA) MBs presented high air permeability and low filtration resistance. High filtration efficiency (>99.8%) could also be obtained especially for the target particles with diameters larger than 2.5 mu m.",
        "keywords": [
            "Dual monomer",
            "melt grafting",
            "poly(lactic acid)",
            "polyamide 11",
            "melt-blown nonwovens",
            "filtration"
        ],
        "authors": [
            {
                "name": "Feichao Zhu",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Juanjuan Su",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Mingjun Wang",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Munir Hussain",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Jian Han",
                "org": "Zhejiang Sci Tech Univ, Hangzhou, Zhejiang, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF INDUSTRIAL TEXTILES",
        "year": 2020
    },
    "CZnC7aRt": {
        "id": "CZnC7aRt",
        "title": "Study on PLA/PA11 Bio-Based Toughening Melt-Blown Nonwovens",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Feichao Zhu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Juanjuan Su",
                "org": ""
            },
            {
                "name": "Jian Han",
                "org": ""
            }
        ],
        "venue": "Autex Research Journal",
        "year": 2019
    },
    "RuE7hb7f": {
        "id": "RuE7hb7f",
        "title": "Functionalization of Polypropylene Nonwoven Fabrics Using Cold Plasma (O2) for developing Graphene-Based Wearable Sensors",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Mehedi Hasan",
                "org": ""
            },
            {
                "name": "Feichao Zhu",
                "org": ""
            },
            {
                "name": "Arsalan Ahmed",
                "org": ""
            },
            {
                "name": "Nazakat Ali Khoso",
                "org": ""
            },
            {
                "name": "Hridam Deb",
                "org": ""
            },
            {
                "name": "Lai Yuchao",
                "org": ""
            },
            {
                "name": "Zahidul Islam",
                "org": ""
            },
            {
                "name": "Hui Sun",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Sensors and Actuators A-physical",
        "year": 2019
    },
    "gK516da0": {
        "id": "gK516da0",
        "title": "Effect of PCL and Compatibilizer on the Tensile and Barrier Properties of PLA/PCL Films",
        "abstract": "In this work, the blend films of poly(lactic acid) (PLA) and poly(e-caprolactone) (PCL) were prepared by the solvent casting method. The influence of PCL content and compatibilizer on the structure, tensile and barrier properties was studied. The results indicated that PCL showed good dispersion in PLA matrix as tributyl citrate (TBC) was added as a compatibilizer. PCL showed a promotion effect on the crystallinity of PLA/PCL films. The compatibility of PLA and PCL was improved by TBC. The tensile modulus and the elongation at break of PLA/PCL films increased to various extents due to the input of PCL and TBC compared to pure PLA film. The improvement of oxygen and water vapor barrier properties of the blend films were provided and depended on the content of PCL and the appearance of TBC. The transparency of the blend films decreased with the increase of the PCL content.",
        "keywords": "",
        "authors": [
            {
                "name": "Hui Sun",
                "org": ""
            },
            {
                "name": "Aiju Xiao",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Gajanan S. Bhat",
                "org": ""
            },
            {
                "name": "Feichao Zhu",
                "org": ""
            }
        ],
        "venue": "Polymer-korea",
        "year": 2017
    },
    "Ff1ye0jr": {
        "id": "Ff1ye0jr",
        "title": "Effects of Poly(ϵ-caprolactone) on Structure and Properties of Poly(lactic acid)/Poly(ϵ-caprolactone) Meltblown Nonwoven",
        "abstract": "",
        "keywords": [
            "structure",
            "property"
        ],
        "authors": [
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "hui sun",
                "org": ""
            },
            {
                "name": "yongmin cao",
                "org": ""
            },
            {
                "name": "jian han",
                "org": ""
            },
            {
                "name": "jinjin kong",
                "org": ""
            },
            {
                "name": "peng wang",
                "org": ""
            },
            {
                "name": "feichao zhu",
                "org": ""
            }
        ],
        "venue": "Polymer-plastics Technology and Engineering",
        "year": 2014
    },
    "3wPLPqlo": {
        "id": "3wPLPqlo",
        "title": "Preparation and properties of poly (lactic acid)/magnetic Fe3O4 composites and nonwovens",
        "abstract": "To develop degradable and magnetic PLA-based melt-blown (MB) nonwoven materials for air filtration applications, poly (lactic acid) (PLA)/magnetic Fe3O4 (PLA/Fe3O4) MB nonwovens were obtained by melt blowing using the PLA/Fe3O4 composites with different components prepared by melt-mixing as the masterbatch. The crystallization and melting behavior of the composites were examined with differential scanning calorimetry (DSC). Although the results showed that the Fe3O4 particles obviously hindered the cold crystallization process of PLA and the relative crystallinity degree of the composites decreased due to the addition of Fe3O4; there was no overall change in the crystal structure of PLA according to the wide-angle X-ray diffraction (XRD). Thermogravimetric analysis (TGA) and dynamic rheological measurements demonstrated that the introduction of Fe3O4 reduced the thermal stability of PLA. The effect of Fe3O4 particles on the morphology of the PLA/Fe3O4 composites and MB nonwovens was characterized by scanning electron microscopy (SEM). It revealed that the Fe3O4 particles were dispersed in a PLA mixture with the \"sea-island\" structure, and the addition of Fe3O4 particles also made the fiber surface rough and the nonwoven web turned fluffy to some extent. The magnetic properties and filtration performance of the MB nonwovens were also investigated in detail.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Zhejiang Sci Tech Univ, Key Lab Ind Text Mat & Mfg Technol, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Mingjun Wang",
                "org": "Zhejiang Sci Tech Univ, Key Lab Ind Text Mat & Mfg Technol, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Hui Sun",
                "org": "Zhejiang Sci Tech Univ, Key Lab Ind Text Mat & Mfg Technol, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Feichao Zhu",
                "org": "Zhejiang Sci Tech Univ, Key Lab Ind Text Mat & Mfg Technol, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Jian Han",
                "org": "Zhejiang Sci Tech Univ, Key Lab Ind Text Mat & Mfg Technol, Hangzhou, Zhejiang, Peoples R China"
            },
            {
                "name": "Gajanan S. Bhat",
                "org": "Univ Georgia, Dept Text Merchandising & Interiors, Athens, GA 30602 USA"
            }
        ],
        "venue": "RSC ADVANCES",
        "year": 2017
    },
    "Dlct6w1q": {
        "id": "Dlct6w1q",
        "title": "LMPP Effects on Morphology, Crystallization, Thermal and Mechanical Properties of iPP/LMPP Blend Fibres",
        "abstract": "The thermal properties and morphological characterisation of isotactic polypropylene (iPP) homopolymer and its blends with low molecular low modulus polypropylene (LMPP) were studied. Firstly blends were prepared with variant LMPP contents, and their properties were characterised using SEM, DSC, XRD, and DMA. Later the mechanical properties of iPP/LMPP blend fibres were investigated. SEM results showed that the iPP/LMPP blends produced smoother surfaces when the LMPP content was increased, as well as the miscibility. All the T-g values with different LMPP percentages were in-between pure iPP and LMPP. The XRD results indicated the LMPP percentage decreased along with the degree of crystallinity of the iPP/LMPP blends (5% to 15%), which increased and then decreased as compared to pure iPP. The elongation at break increased when the LMPP content increased, with the maximum elongation at break of the LMPP 25% blend reaching 12.95%, which showed great stretch-ability, whereas the elastic modulus of iPP/LMPP blends decreased.",
        "keywords": [
            "polypropylene",
            "iPP/LMPP blends",
            "morphology",
            "crystallinity",
            "low molecular low modulus polypropylene"
        ],
        "authors": [
            {
                "name": "Munir Hussain",
                "org": "Zhejiang Sci Tech Univ, Sch Mat & Text, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Feichao Zhu",
                "org": "Zhejiang Sci Tech Univ, Sch Mat & Text, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Sci Tech Univ, Sch Mat & Text, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Jian Han",
                "org": "Zhejiang Sci Tech Univ, Sch Mat & Text, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Hafeezullah Memon",
                "org": "Zhejiang Sci Tech Univ, Sch Mat & Text, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Sohail Yasin",
                "org": "Politecn Torino, Corso Giuseppe Pella, I-13900 Biella, Italy"
            }
        ],
        "venue": "FIBRES & TEXTILES IN EASTERN EUROPE",
        "year": 2018
    },
    "eo95YxKn": {
        "id": "eo95YxKn",
        "title": "멜트블론 부직포 제조를 위한 PLA/PCL 블렌드의 미세구조,열적특성, 및 유변학적 성질",
        "abstract": "",
        "keywords": [
            "poly",
            "microstructure"
        ],
        "authors": [
            {
                "name": "hui sun",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "jan han",
                "org": ""
            },
            {
                "name": "jinjin kong",
                "org": ""
            },
            {
                "name": "lingrui meng",
                "org": ""
            },
            {
                "name": "feichao zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "v1XHQdNE": {
        "id": "v1XHQdNE",
        "title": "Influence of halloysite nanotubes on poly(lactic acid) melt-blown nonwovens compatibilized by dual-monomer melt-grafted poly(lactic acid)",
        "abstract": "To develop fully biodegradable and reinforced poly(lactic acid) (PLA) melt-blown nonwovens (MBs) for separation and filtration, PLA/aminated halloysite nanotubes (PLA/A-HNTs) MBs were prepared using PLA/A-HNTs master-batches, compatibilized by dual-monomer glycidyl methacrylate-styrene (St-co-GMA) melt-grafted PLA (PLA-g-(St-co-GMA)). The morphology, crystallization, pore size distribution, filtration performance, and mechanical properties of PLA/PLA-g-(St-co-GMA)/A-HNTs MBs were characterized. The results indicated that PLA/PLA-g-(St-co-GMA)/A-HNT MBs could be successfully manufactured, with well dispersed A-HNTs in PLA MB fibers due to improved compatibility by PLA-g-(St-co-GMA). Incorporation of A-HNTs and PLA-g-(St-co-GMA) slightly increased the average diameter and pore size of PLA MBs. A-HNTs increased the crystallinity degree of PLA MBs, while the crystal forms remained unchanged. In comparison with PLA MBs, the tensile strengths of PLA/PLA-g-(St-co-GMA)/A-HNTs MBs were enhanced but the elongation decreased. PLA/PLA-g-(St-co-GMA)/A-HNT MBs could obtain higher filtration efficiency than neat PLA MBs.",
        "keywords": [
            "poly(lactic acid)",
            "halloysites",
            "dual-monomer grafting",
            "compatibilization",
            "melt-blown nonwovens",
            "filtration"
        ],
        "authors": [
            {
                "name": "Feichao Zhu",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Juanjuan Su",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Yonghuan Zhao",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Munir Hussain",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Sohail Yasin",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            },
            {
                "name": "Jian Han",
                "org": "Zhejiang Sci Tech Univ, 928,2nd Ave,Xiasha Higher Educ Pk, Hangzhou 310018, Zhejiang, Peoples R China"
            }
        ],
        "venue": "TEXTILE RESEARCH JOURNAL",
        "year": 2019
    },
    "VDwekcA5": {
        "id": "VDwekcA5",
        "title": "The Structure and Properties of Biodegradable PLLA/PDLA for Melt-Blown Nonwovens",
        "abstract": "Poly(l-lactic acid) (PLLA) and poly(d-lactic acid) (PDLA) blends with various compositions, utilized for melt-blown nonwovens, were prepared by a melt blending method. Their structure and properties were investigated by differential scanning calorimetry, thermal mechanical analyzer (DMA), X-ray diffraction, polarized optical microscope, field emission scanning electron microscope, and a universal testing machine, respectively. The results showed that the addition of PDLA decreased the glass transition temperature of PLLA. The PLLA/PDLA blends with the 0.3 % PDLA had the lowest the melting temperature and the degree of crystallization. The growth rate and size of the spherulites of the blends increased with the increase of the PDLA content. PLA stereocomplex could be achieved in the PLLA/PDLA blends. PDLA phase was dispersed uniformly in PLLA matrix in the formation of small circular particles. An increase of the PDLA content resulted in the improvement of the fracture toughness of the blends. When the PDLA content was 0.3 %, the blends achieved the highest elongation at break and toughness. Moreover, PDLA had a positive effect on the enhancement of the toughness of PLLA/PDLA melt-blown nonwovens.",
        "keywords": [
            "Poly(l-lactic acid)",
            " Poly(d-lactic acid)",
            " Structure",
            " Toughness",
            " Nonwoven"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Zhejiang Sci-Tech University"
            },
            {
                "name": "Yongmin Cao",
                "org": "Key Lab of Industrial Textile Materials and Manufacturing Technology"
            },
            {
                "name": "Hui Sun",
                "org": "Zhejiang Sci-Tech University"
            },
            {
                "name": "Jian Han",
                "org": "Zhejiang Sci-Tech University"
            }
        ],
        "venue": "Journal of Polymers and The Environment",
        "year": 2017
    },
    "KUuPogo4": {
        "id": "KUuPogo4",
        "title": "Role of Noncanonical Wnt Signaling Pathway in Human Aortic Valve Calcification.",
        "abstract": "These findings suggest a potential role for noncanonical Wnt signaling in the pathogenesis of aortic valve calcification.",
        "keywords": [
            "aortic valve",
            "bone marrow",
            "calcium",
            "human",
            "lipids"
        ],
        "authors": [
            {
                "name": "Isabella Albanese",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Bin Yu",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Hamood Al-Kindi",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Bianca Barratt",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Leah Ott",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Mohammad Al-Refai",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Benoit de Varennes",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Dominique Shum-Tim",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Marta Cerruti",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Ophélie Gourgas",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Eric Rhéaume",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Jean-Claude Tardif",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.)."
            },
            {
                "name": "Adel Schwertani",
                "org": "From the Division of Cardiology and Division of Cardiac Surgery, McGill University Health Centre, Montreal, Quebec, Canada (I.A., B.Y., H.A.-K., B.B., L.O., M.A.-R., B.d.V., D.S.-T., A.S.); Department of Material Engineering, McGill University, Montreal, Quebec, Canada (M.C., O.G.); and Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada (E.R., J.C.T.). adel.schwertani@mcgill.ca."
            }
        ],
        "venue": "Arteriosclerosis, thrombosis, and vascular biology",
        "year": 2017
    },
    "GIiPUhBd": {
        "id": "GIiPUhBd",
        "title": "The cytoprotective impact of yes-associated protein 1 after ischemia-reperfusion injury in AC16 human cardiomyocytes.",
        "abstract": "Genetically engineering the cells of the heart after myocardial infarction to display a more regenerative phenotype is a promising therapy for heart failure patients. Here, we support a regenerative role for yes-associated protein 1, the main effector protein of the Hippo signaling pathway, in AC16 human cardiomyocytes as a potential therapeutic gene target for cardiac repair after myocardial infarction.",
        "keywords": [
            "Hippo",
            "Human",
            "Wnt",
            "YAP1",
            "cardiomyocyte",
            "cytoprotection",
            "hypertrophy",
            "myocardial infarction",
            "reactive oxygen species"
        ],
        "authors": [
            {
                "name": "Kashif Khan",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec H4AJ1, Canada."
            },
            {
                "name": "Georges Makhoul",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec H4AJ1, Canada."
            },
            {
                "name": "Bin Yu",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec H4AJ1, Canada."
            },
            {
                "name": "Adel Schwertani",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec H4AJ1, Canada."
            },
            {
                "name": "Renzo Cecere",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Centre, Montreal, Quebec H4AJ1, Canada."
            }
        ],
        "venue": "Experimental biology and medicine (Maywood, N.J.)",
        "year": 2019
    },
    "Lq6GZx9Q": {
        "id": "Lq6GZx9Q",
        "title": "CYTOPROTECTIVE IMPACT OF YES-ASSOCIATED PROTEIN 1 TO CARDIOMYOCYTES AFTER ISCHEMIA-REPERFUSION INJURY",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "K. Khan",
                "org": ""
            },
            {
                "name": "Georges Makhoul",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Adel Schwertani",
                "org": ""
            },
            {
                "name": "Renzo Cecere",
                "org": ""
            }
        ],
        "venue": "Canadian Journal of Cardiology",
        "year": 2018
    },
    "0Q6iHj6q": {
        "id": "0Q6iHj6q",
        "title": "Lipoprotein(a) Induces Human Aortic Valve Interstitial Cell Calcification.",
        "abstract": "•Lp(a) significantly increased alkaline phosphatase activity, phosphate and calcium content, and matrix vesicle formation and induced apoptosis and calcification of normal human aortic valve interstitial cells.•The type of minerals induced by Lp(a) resembles that seen in calcified human aortic valves as shown by Raman spectroscopy.•Lp(a)-induced calcification of human aortic valve interstitial cells is mediated by activation of MAPK38, GSK3β, and Wnt signaling.•Inhibition of GSK3β and MAPK38 significantly reduced lipoprotein(a)-induced aortic valve interstitial cell calcification.•Lp(a)is abundant in calcified aortic valves, and lipoprotein(a) immunoreactivity colocalized with that of oxidized phospholipids.",
        "keywords": [
            "oxidized phospholipids",
            "Raman spectroscopy",
            "real-time PCR",
            "stenosis"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Anouar Hafiane",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "George Thanassoulis",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Leah Ott",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Nial Filwood",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Marta Cerruti",
                "org": "Department of Materials Engineering, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Ophélie Gourgas",
                "org": "Department of Materials Engineering, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Dominique Shum-Tim",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Hamood Al Kindi",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Benoit de Varennes",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Alawi Alsheikh-Ali",
                "org": "College of Medicine, Mohammed Bin Rashid University of Medical and Health Sciences, Dubai, United Arab Emirates"
            },
            {
                "name": "Jacques Genest",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Adel Schwertani",
                "org": "Divisions of Cardiology and Cardiac Surgery, Department of Medicine, Surgery and Pathology, McGill University, Montreal, Quebec, Canada"
            }
        ],
        "venue": "JACC: Basic to Translational Science",
        "year": 2017
    },
    "sWcbJTzy": {
        "id": "sWcbJTzy",
        "title": "Pathological significance of lipoprotein(a) in aortic valve stenosis.",
        "abstract": "The present study outlines an association between Lp(a) and AVS, and suggests that Lp(a) may serve as a potential target for therapeutic purposes to manage the progression of AVS.",
        "keywords": [
            "Aortic valve stenosis",
            "Calcium",
            "ELISA",
            "Human",
            "MS/MS",
            "Oxidant formation",
            "Oxidized phospholipids"
        ],
        "authors": [
            {
                "name": "Bin Yu",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Kashif Khan",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Qutayba Hamid",
                "org": "McGill University and University of Sharjah, United Arab Emirates."
            },
            {
                "name": "Ahmad Mardini",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Ateeque Siddique",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Louis Philippe Aguilar-Gonzalez",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Georges Makhoul",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Hossny Alaws",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Jacques Genest",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "George Thanassoulis",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Renzo Cecere",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada."
            },
            {
                "name": "Adel Schwertani",
                "org": "Divisions of Cardiology and Cardiac Surgery, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, Quebec, H4A 3J1, Canada. Electronic address: adel.schwertani@mcgill.ca."
            }
        ],
        "venue": "Atherosclerosis",
        "year": 2018
    },
    "9s4nsqy7": {
        "id": "9s4nsqy7",
        "title": "A position sensitive ionization chamber for thermal neutrons",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Gretchen J. Mahler",
                "org": ""
            },
            {
                "name": "N. A. Schaknowski",
                "org": ""
            },
            {
                "name": "Gillian C. Smith",
                "org": ""
            }
        ],
        "venue": "Oral Oncology",
        "year": 2000
    },
    "ikwAHtYE": {
        "id": "ikwAHtYE",
        "title": "The Urotensin II System and Carotid Atherosclerosis: A Role in Vascular Calcification.",
        "abstract": "Upregulation of UII, URP, and UT in unstable carotid endarterectomy plaques and plasma, and the stimulatory effect of UII on vascular smooth muscle cell calcification suggest that the UII system may play a role in the pathogenesis of vascular calcification and stability of atherosclerosis.",
        "keywords": [
            "UII",
            "URP",
            "UT",
            "calcium",
            "immunohistochemistry",
            "smooth muscle cells",
            "urotensin II",
            "urotensin II-related peptide"
        ],
        "authors": [
            {
                "name": "Isabella Albanese",
                "org": "Cardiology, McGill University Health Center Montreal, QC, Canada."
            },
            {
                "name": "Stella S Daskalopoulou",
                "org": "Cardiology, McGill University Health Center Montreal, QC, Canada."
            },
            {
                "name": "Bin Yu",
                "org": "Cardiology, McGill University Health Center Montreal, QC, Canada."
            },
            {
                "name": "Zhipeng You",
                "org": "Cardiology, McGill University Health Center Montreal, QC, Canada."
            },
            {
                "name": "Jacques Genest",
                "org": "Cardiology, McGill University Health Center Montreal, QC, Canada."
            },
            {
                "name": "Alawi Alsheikh-Ali",
                "org": "Cardiology, College of Medicine, Mohammed Bin Rashid University Dubai, UAE."
            },
            {
                "name": "Adel G Schwertani",
                "org": "Cardiology, McGill University Health Center Montreal, QC, Canada."
            }
        ],
        "venue": "Frontiers in pharmacology",
        "year": 2016
    },
    "4b9W6TBx": {
        "id": "4b9W6TBx",
        "title": "Urotensin II, Urotensin-Related Peptide and their Receptor in Aortic Valve Stenosis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Kashif Khan",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            },
            {
                "name": "Isabella Albanese",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            },
            {
                "name": "Bin Yu",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            },
            {
                "name": "Yousif Shalal",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            },
            {
                "name": "Hamood Al-Kindi",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            },
            {
                "name": "Hossney Alaws",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            },
            {
                "name": "Jean-Claude Tardif",
                "org": "Montreal Heart Institute, Montreal, Québec, Canada"
            },
            {
                "name": "Ophélie Gourgas",
                "org": "Department of Materials Engineering, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Marta Cerutti",
                "org": "Department of Materials Engineering, McGill University, Montreal, Quebec, Canada"
            },
            {
                "name": "Adel Schwertani",
                "org": "Cardiology and Cardiac Surgery, McGill University Health Center, Montreal, Quebec, Canada"
            }
        ],
        "venue": "The Journal of Thoracic and Cardiovascular Surgery",
        "year": 2019
    },
    "C8qzcc3G": {
        "id": "C8qzcc3G",
        "title": "Abstract 638: Urotensin II Promotes Calcification in Vascular Smooth Muscle Cells",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Isabella Albanese",
                "org": ""
            },
            {
                "name": "Zhipeng You",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Bianca Barratt",
                "org": ""
            },
            {
                "name": "Dominique Shum-Tim",
                "org": ""
            },
            {
                "name": "Hamood Al Kindi",
                "org": ""
            },
            {
                "name": "Mohammed Alreshidan",
                "org": ""
            },
            {
                "name": "Adel Schwertani",
                "org": ""
            }
        ],
        "venue": "Arteriosclerosis, Thrombosis, and Vascular Biology",
        "year": 2014
    },
    "zFQMu7ft": {
        "id": "zFQMu7ft",
        "title": "Facile preparation of layered melamine-phytate flame retardant via supramolecular self-assembly technology.",
        "abstract": "Melamine-phytate (MEL-PA) nanoflakes are formed by supramolecular self-assembly technology using melamine (MEL) and bio-based phytic acid (PA) as the building blocks. This work explores the possibility of this two-dimensional nanomaterial as flame retardant. The layered MEL-PA with the loading of 1, 2 and 3 wt% are incorporated into polypropylene (PP) matrix. MEL-PA is dispersed well in the PP matrix. Thermal stability and flame retardant performance of PP/MEL-PA composites are investigated. Compared with neat PP, the addition of 2 wt% MEL-PA decreases the peak heat release rate from 756 to 608 kW/m2. Char yield of PP is improved by MEL-PA, and the chemical structure and graphitization degree of residual char are studied to reveal flame retardant mechanism.",
        "keywords": [
            "Fire retardancy",
            "Supramolecular self-assembly",
            "Thermal analysis"
        ],
        "authors": [
            {
                "name": "Sheng Shang",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Bihe Yuan",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Yaru Sun",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Gongqing Chen",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Chuyuan Huang",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Bin Yu",
                "org": "Centre for Future Materials, University of Southern Queensland, Toowoomba, QLD 4350, Australia"
            },
            {
                "name": "Song He",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Huaming Dai",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            },
            {
                "name": "Xianfeng Chen",
                "org": "School of Safety Science and Emergency Management, Wuhan University of Technology, Wuhan 430070, China"
            }
        ],
        "venue": "Journal of Colloid and Interface Science",
        "year": 2019
    },
    "dZOWtITQ": {
        "id": "dZOWtITQ",
        "title": "Facile synthesis of aluminum branched oligo(phenylphosphonate) submicro-particles with enhanced flame retardance and smoke toxicity suppression for epoxy resin composites.",
        "abstract": "A novel and submicro-scale aluminum branched oligo(phenylphosphonate) (AHPP) has been successfully synthesized and embedded into a polymeric substrate to improve the fire safety of epoxy resin (EP). The chemical structures of intermediates and target products were characterized using the nuclear magnetic resonance spectroscopy, X-ray diffraction and Fourier transform infrared analysis. Morphology analysis confirmed that all of the as-synthesized AHPP submicro-particles are mutually well-separated. Combustion results demonstrated that the limiting oxygen index value is increased to 30.5% from 23.5% while the PHRR and THR are decreased by ca. 68.1% and 41.2%, respectively for the EP/AHPP-7.5 composite compared to the corresponding values for pure EP. In addition, the binary blends display the satisfying smoke toxicity suppression performance during combustion. The total smoke production and the total CO yield for EP/AHPP-7.5 are dramatically reduced by 62.0% and 32.3%, respectively, which may mainly be ascribed to the catalytic carbonization performance of the polymers and formation of AlO layers on the surface of the char residues. As a result, the findings in this study enabled the submicro-scale phosphorus-containing flame retardant to be a potential candidate as an efficient additive for reducing smoke toxicity of polymer composites.",
        "keywords": [
            "Branched flame retardant",
            "Epoxy resins",
            "Smoke toxicity suppression",
            "Submicro-scale particles"
        ],
        "authors": [
            {
                "name": "Yao Yuan",
                "org": "Fujian Provincial Key Laboratory of Functional Materials and Applications, School of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, PR China; State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, PR China."
            },
            {
                "name": "Yongqian Shi",
                "org": "College of Environment and Resources, Fuzhou University, Fuzhou 350002, PR China."
            },
            {
                "name": "Bin Yu",
                "org": "Centre for Future Materials, University of Southern Queensland, Toowoomba, QLD 4350, Australia."
            },
            {
                "name": "Jing Zhan",
                "org": "School of Civil Engineering and Environmental Engineering, Anhui Xinhua University, Hefei, Anhui, 230088, PR China."
            },
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, PR China."
            },
            {
                "name": "Lei Song",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, PR China."
            },
            {
                "name": "Chao Ma",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, PR China. Electronic address: mcsky@ustc.edu.cn."
            },
            {
                "name": "Yuan Hu",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, PR China. Electronic address: yuanhu@ustc.edu.cn."
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2019
    },
    "HHLbN9Cx": {
        "id": "HHLbN9Cx",
        "title": "Alumina nanoflake‐coated graphene nanohybrid as a novel flame retardant filler for polypropylene",
        "abstract": "gamma-Al2O3 nanoflakes are decorated on the surface of graphene nanosheets by hydrothermal method. The chemical structures, composition, and morphology of the graphene nanohybrid are characterized. Alumina nanoflake-coated graphene nanohybrid is incorporated into polypropylene (PP) matrix by master batch-based melt mixing method. The effects of alumina-graphene nanohybrid on the thermal stability and combustion behavior of PP are investigated. More char residue is left for PP composite containing alumina-graphene nanohybrid. Peak heat release rate of pure PP is greatly decreased by this nanohybrid, corresponding to 30.6% reduction. Fire safety of PP is considerably enhanced. Flame retardant mechanisms are concluded based on the combustion results and char analysis. The barrier effect of graphene and catalytic charring actions of gamma-Al2O3 nanoflakes make the contribution to the enhanced flame retardant properties.",
        "keywords": [
            "alumina",
            "flame retardant",
            "graphene",
            "thermal stability"
        ],
        "authors": [
            {
                "name": "Bihe Yuan",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            },
            {
                "name": "Gongqing Chen",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            },
            {
                "name": "Yanyan Zou",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            },
            {
                "name": "Sheng Shang",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            },
            {
                "name": "Yaru Sun",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "Univ Southern Queensland, Ctr Future Mat, Toowoomba, Qld 4350, Australia"
            },
            {
                "name": "Song He",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            },
            {
                "name": "Xianfeng Chen",
                "org": "Wuhan Univ Technol, Sch Safety Sci & Emergency Management, Wuhan 430070, Hubei, Peoples R China"
            }
        ],
        "venue": "POLYMERS FOR ADVANCED TECHNOLOGIES",
        "year": 2019
    },
    "1v1as1OQ": {
        "id": "1v1as1OQ",
        "title": "Strengthening, toughing and thermally stable ultra-thin MXene nanosheets/polypropylene nanocomposites via nanoconfinement",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongqian Shi",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, People’s Republic of China"
            },
            {
                "name": "Chuan Liu",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, People’s Republic of China"
            },
            {
                "name": "Lu Liu",
                "org": "Hefei Institute for Public Safety Research, Tsinghua University, 5999 Xiyou Road, Hefei, Anhui 230026, People’s Republic of China"
            },
            {
                "name": "Libu Fu",
                "org": "College of Civil Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, People’s Republic of China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Architecture and Civil Engineering, City University of Hong Kong, 88 Tat Chee Avenue, Kowloon, Hong Kong, People’s Republic of China"
            },
            {
                "name": "Yuancai Lv",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, People’s Republic of China"
            },
            {
                "name": "Fuqiang Yang",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, People’s Republic of China"
            },
            {
                "name": "Pingan Song",
                "org": "Centre for Future Materials, University of Southern Queensland, Toowoomba, QLD 4350, Australia"
            }
        ],
        "venue": "Chemical Engineering Journal",
        "year": 2019
    },
    "T9yZSONp": {
        "id": "T9yZSONp",
        "title": "Functionalized graphene/thermoplastic polyester elastomer nanocomposites by reactive extrusion-based masterbatch: preparation and properties reinforcement: FUNCTIONALIZED GRAPHENE/TPEE NANOCOMPOSITES",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yuan hu",
                "org": ""
            },
            {
                "name": "lei song",
                "org": ""
            },
            {
                "name": "yongqian shi",
                "org": ""
            },
            {
                "name": "haifeng pan",
                "org": ""
            },
            {
                "name": "wei yang",
                "org": ""
            },
            {
                "name": "xiaodong qian",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "liyan ma",
                "org": ""
            }
        ],
        "venue": "Polymers for Advanced Technologies",
        "year": 2014
    },
    "mYLmsCS6": {
        "id": "mYLmsCS6",
        "title": "Highly Effective Flame-Retardant Rigid Polyurethane Foams: Fabrication and Applications in Inhibition of Coal Combustion.",
        "abstract": "The extemporaneous combustion of coal remains a major threat to safety in coal mines because such fire accidents result in casualties and significant property loss, as well as serious environmental pollution. This work proposed the fabrication of flame-retardant rigid polyurethane foam (RPUF) containing expandable graphite as char expander/sealant with melamine phosphosphate and 2-carboxyethyl (phenyl)phosphinic acid as char inducer and radical trapping agents. The as-prepared RPUF successfully inhibited coal combustion by forming thermally stable high graphitic content expandable intumescent char sealing over the coal. The RPUF achieved UL-94 V-0 rating in addition to significant reductions in peak heat release, total heat release, and CO and CO yields. The external and the internal residual char structure was studied by X-ray photoelectron spectra, Raman spectroscopy, and real-time Fourier transform infrared spectra techniques, and a flame-retardant mode of action has been proposed. This work provides important insight into a facile fabrication of highly efficient and economical flame-retardant RPUF to inhibit the spontaneous combustion of coal.",
        "keywords": [
            "Polyurethane foam",
            "coal combustion",
            "expandable graphite",
            "intumescent flame-retardant",
            "phosphorus"
        ],
        "authors": [
            {
                "name": "Liancong Wang",
                "org": "State Key Laboratory of Coal Mine Safety Technology, CCTEG Shenyang Research Institute, Fushun 113122, China. wangliancong-0829@163.com."
            },
            {
                "name": "Benjamin Tawiah",
                "org": "Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong 999077, China. tawiahb@gmail.com."
            },
            {
                "name": "Yongqian Shi",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. shiyq1986@fzu.edu.cn."
            },
            {
                "name": "Suncheng Cai",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. dandy_cai@163.com."
            },
            {
                "name": "Xiaohui Rao",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. Rxh123456789m88@163.com."
            },
            {
                "name": "Chuan Liu",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. liuchuanll@163.com."
            },
            {
                "name": "Ye Yang",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. ys19750873@163.com."
            },
            {
                "name": "Fuqiang Yang",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. fqouyang82@163.com."
            },
            {
                "name": "Bin Yu",
                "org": "Centre for Future Materials, University of Southern Queensland, Toowoomba QLD 4350, Australia. ahu07yb@gmail.com."
            },
            {
                "name": "Yuntao Liang",
                "org": "State Key Laboratory of Coal Mine Safety Technology, CCTEG Shenyang Research Institute, Fushun 113122, China. liangyt@fsccri.com."
            },
            {
                "name": "Libi Fu",
                "org": "College of Civil Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou 350116, China. fulibi@fzu.edu.cn."
            }
        ],
        "venue": "Polymers",
        "year": 2019
    },
    "n77D11Dn": {
        "id": "n77D11Dn",
        "title": "Hierarchical assembly of polystyrene/graphitic carbon nitride/reduced graphene oxide nanocomposites toward high fire safety",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongqian Shi",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350116, PR China"
            },
            {
                "name": "Chuan Liu",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350116, PR China"
            },
            {
                "name": "Libi Fu",
                "org": "College of Civil Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350116, PR China"
            },
            {
                "name": "Fuqiang Yang",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350116, PR China"
            },
            {
                "name": "Yuancai Lv",
                "org": "College of Environment and Resources, Fuzhou University, 2 Xueyuan Road, Fuzhou, 350116, PR China"
            },
            {
                "name": "Bin Yu",
                "org": "Centre for Future Materials, University of Southern Queensland, Toowoomba, QLD, 4350, Australia"
            }
        ],
        "venue": "Composites Part B-engineering",
        "year": 2019
    },
    "TcQ6gQrW": {
        "id": "TcQ6gQrW",
        "title": "Influence of g-C 3 N 4 Nanosheets on Thermal Stability and Mechanical Properties of Biopolymer Electrolyte Nanocomposite Films: A Novel Investigation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "richard k k yuen",
                "org": ""
            },
            {
                "name": "yuan hu",
                "org": ""
            },
            {
                "name": "zhou gui",
                "org": ""
            },
            {
                "name": "panyue wen",
                "org": ""
            },
            {
                "name": "ningning hong",
                "org": ""
            },
            {
                "name": "bibo wang",
                "org": ""
            },
            {
                "name": "xiaodong qian",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "chenlu bao",
                "org": ""
            },
            {
                "name": "keqing zhou",
                "org": ""
            },
            {
                "name": "saihua jiang",
                "org": ""
            },
            {
                "name": "yongqian shi",
                "org": ""
            }
        ],
        "venue": "ACS Applied Materials & Interfaces",
        "year": 2014
    },
    "vuUTk6VE": {
        "id": "vuUTk6VE",
        "title": "Robust, Lightweight, Hydrophobic and Fire Retarded Polyimide/MXene Aerogels for Effective Oil/Water Separation.",
        "abstract": "Polyimide (PI) aerogels have attracted great attention owing to their low density and excellent thermal stability. However, hydrophobic surface modification is required for PI aerogels to improve their ability in oil/water separation applications due to their amphiphilic characteristic. 2D MXenes (transition metal carbides/nitrides) can be utilized as nanofillers to enhance the properties of polymers because of their unique layered structure and versatile interface chemistry. Herein, the robust, lightweight and hydrophobic polyimide/MXene 3D architectures were fabricated via freeze-drying of polyamide acid/MXene suspensions and thermal imidization. Polyamide acid (PAA) was synthesized using N-N-dimethylacetamide (DMAC) and 4,4'-oxydianiline (ODA). MXene (Ti3C2Tx) dispersion was obtained via the etching of Ti3AlC2 and ultrasonic exfoliation. Taking advantage of the strong interaction between PI chains and MXene nanosheets, the interconnected, highly porous and hydrophobic PI/MXene aerogels with low density were fabricated, resulting in the improved compressive performance, remarkable oil absorption capacity and efficient separation of oil and water. For the PI/MXene-3 aerogel (weight ratio: 5.2/1) without any surface modification, the water contact angle was 119° with a density of 23 mg/cm3. This aerogel can completely recover to its original height after 50 compression-release cycles, exhibiting super elasticity and exceptional fatigue resistant ability. It also showed high absorption capacities to various organic liquids ranging from approximately 18 to 58 times of their own weight. This hybrid aerogel can rapidly separate the chloroform, soybean oil and liquid paraffin from the water-oil system. The thermally stable hybrid aerogel also exhibited excellent fire safety properties and outstanding reusability under extreme environment.",
        "keywords": [
            "polyimide",
            "MXene",
            "aerogel",
            "oil/water separation",
            "flame retardant"
        ],
        "authors": [
            {
                "name": "Ning-Ning Wang",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Hao Wang",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Yu-Ying Wang",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "You-Hao Wei",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Jing-Yu Si",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Anthony Chun Yin Yuen",
                "org": "Univ New South Wales, Sch Mech & Mfg Engn, Sydney, NSW 2052, Australia"
            },
            {
                "name": "Jin-Song Xie",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Bin Yu",
                "org": "City Univ Hong Kong, Dept Architecture & Civil Engn, Kowloon, 88 Tat Chee Ave, Hong Kong, Peoples R China"
            },
            {
                "name": "San-E Zhu",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Hong-Dian Lu",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Wei Yang",
                "org": "Hefei Univ, Dept Chem & Mat Engn, Hefei 230601, Anhui, Peoples R China"
            },
            {
                "name": "Qing Nian Chan",
                "org": "Univ New South Wales, Sch Mech & Mfg Engn, Sydney, NSW 2052, Australia"
            },
            {
                "name": "Guan-Heng Yeoh",
                "org": "Univ New South Wales, Sch Mech & Mfg Engn, Sydney, NSW 2052, Australia"
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2019
    },
    "VPHkxxvO": {
        "id": "VPHkxxvO",
        "title": "Simultaneous fire safety enhancement and mechanical reinforcement of poly(lactic acid) biocomposites with hexaphenyl (nitrilotris(ethane-2,1-diyl))tris(phosphoramidate).",
        "abstract": "•Cyclo-phosphorus-nitrogen FR (HNETP) was successfully synthesized.•HNETP enhanced the fire safety of PLA considerably.•The fire performance and fire growth index improved tremendously.•PLA/HNETP composite reduced pyrolysis gaseous products.•HNETP enhanced the tensile strength of PLA considerably.",
        "keywords": [
            "Flame retardant",
            "Poly(lactic acid)",
            "Cone calorimeter",
            "Mechanical properties",
            "Biocomposites"
        ],
        "authors": [
            {
                "name": "Benjamin Tawiah",
                "org": "Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong, China"
            },
            {
                "name": "Bin Yu",
                "org": "Department of Civil and Architectural Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"
            },
            {
                "name": "Ruichao Wei",
                "org": "Department of Civil and Architectural Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"
            },
            {
                "name": "Richard K K Yuen",
                "org": "Department of Civil and Architectural Engineering, City University of Hong Kong, Kowloon, Hong Kong, China"
            },
            {
                "name": "Wei Chen",
                "org": "Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong, China"
            },
            {
                "name": "John H Xin",
                "org": "Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong, China"
            },
            {
                "name": "Bin Fei",
                "org": "Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong, China"
            }
        ],
        "venue": "Journal of Hazardous Materials",
        "year": 2019
    },
    "1kYvTM0w": {
        "id": "1kYvTM0w",
        "title": "Preparation of microcapsulated ammonium polyphosphate, pentaerythritol with glycidyl methacrylate, butyl methacrylate and their synergistic flame- retardancy for ethylene vinyl acetate copolymer: MICROENCAPSULATED APP AND PER WITH GMA AND BMA SHELLS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongqian shi",
                "org": ""
            },
            {
                "name": "qinbo tang",
                "org": ""
            },
            {
                "name": "bibo wang",
                "org": ""
            },
            {
                "name": "bin yu",
                "org": ""
            },
            {
                "name": "xiaodong qian",
                "org": ""
            },
            {
                "name": "gang tang",
                "org": ""
            },
            {
                "name": "yuan hu",
                "org": ""
            },
            {
                "name": "lei song",
                "org": ""
            }
        ],
        "venue": "Polymers for Advanced Technologies",
        "year": 2013
    },
    "9Z7hDSSs": {
        "id": "9Z7hDSSs",
        "title": "Novel temperature‐sensitive and pH‐sensitive polyurethane membranes: preparation and characterization",
        "abstract": "",
        "keywords": [
            "membrane",
            "water absorption"
        ],
        "authors": [
            {
                "name": "hu zhou",
                "org": "hunan university of science and technology"
            },
            {
                "name": "bin yu",
                "org": "hunan university of science and technology"
            },
            {
                "name": "ruiping xun",
                "org": "hunan university of science and technology"
            },
            {
                "name": "ning li",
                "org": "hunan university of science and technology"
            },
            {
                "name": "kejian wu",
                "org": "hunan university of science and technology"
            },
            {
                "name": "hanzhou sun",
                "org": "central south university forestry and technology"
            },
            {
                "name": "zhihua zhou",
                "org": "hunan university of science and technology"
            }
        ],
        "venue": "Asia-Pacific Journal of Chemical Engineering",
        "year": 2015
    },
    "CI6yumSD": {
        "id": "CI6yumSD",
        "title": "A Novel Thermal- and pH-Sensitive Polyurethane Hydrogel for Adsorption of Pb2+ from Aqueous Solutions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hu Zhou",
                "org": ""
            },
            {
                "name": "Yizhi Xiong",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Taofen Wang",
                "org": ""
            },
            {
                "name": "Hexiu Liu",
                "org": ""
            },
            {
                "name": "Lingwei Zeng",
                "org": ""
            },
            {
                "name": "Jie Zhou",
                "org": ""
            },
            {
                "name": "Xiaohong Wang",
                "org": ""
            },
            {
                "name": "Yuguang Sui",
                "org": ""
            }
        ],
        "venue": "Journal of Biobased Materials and Bioenergy",
        "year": 2017
    },
    "t9Lzn4AK": {
        "id": "t9Lzn4AK",
        "title": "Characterization of Collagen Fiber/BaSO4 Hybrid Materials and Their Applications in Free Fatty Acids Adsorption",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hu Zhou",
                "org": ""
            },
            {
                "name": "Jie Zhou",
                "org": ""
            },
            {
                "name": "Yizhi Xiong",
                "org": ""
            },
            {
                "name": "Jianxian Zeng",
                "org": ""
            },
            {
                "name": "Zhihua Zhou",
                "org": ""
            },
            {
                "name": "Xuan Liu",
                "org": ""
            },
            {
                "name": "Guoqing Liu",
                "org": ""
            },
            {
                "name": "Qingquan Liu",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            }
        ],
        "venue": "Journal of Biobased Materials and Bioenergy",
        "year": 2016
    },
    "LpfLLdU2": {
        "id": "LpfLLdU2",
        "title": "Preparation and performances of coated and aluminous entry boards with water-soluble resins for PCB drilling",
        "abstract": "PurposeThis paper aims to provide a new drilling entry board for printed circuit board (PCB) process, superior in heat dissipation, lubrication, water solubility and hole location accuracy, achieving an excellent drilling process.Design/methodology/approachUsing a mixture of polyethylene glycol (PEG) and water-soluble adhesives as hydrosoluble, endothermic and lubricant resins and aluminum foils as baseplates, a series of coated and aluminous entry boards (CABs) for PCB drilling was successfully prepared. The surface appearance of the entry boards was observed clearly by scanning electron microscopy (SEM). The endothermic and lubricant effects of the resins applied on the CABs was characterized by differential scanning calorimetry (DSC) and their water solubility was tested in the normal-temperature water (25°C). Moreover, the CABs’ good drilling properties were tested when they were used for PCB drilling.FindingsThe SEM analysis showed that the surfaces of the resin layers coated on the CABs whose coating thicknesses were less than 80 μm were smoother and flatter, which could improve hole location accuracy and reduce drill breakage ratio. By virtue of DSC, the endothermic and lubricant effects of the CABs were proven. The fusion of PEG in the resin layers could absorb the heat produced by drilling, restrain the temperature of the drill bit and hole rising and lubricate the drill bit efficiently when a hole was being drilled, which could achieve high-quality holes with good production efficiency. The water-soluble test showed that the prepared CABs had excellent water solubility at normal temperature, enabling the resin left on the hole walls and in the flute of the drill bit to be washed away easily and thereby improving the drilling efficiency and quality. The drilling tests showed that the increase in the thickness of the CABs’ coating could improve the hole location accuracy and alleviate the bit wear. In addition, the suitable coating thickness could ensure the firm adhering of the resin coating the aluminum foil, effectively avoid drill intertwist and prevent the resin debris from blocking the drilled holes on the surface of the entry board, which could hinder chip removal, resulting in poor hole wall quality and drill breakage.Originality/valueThis paper has a remarkably high industrial practicality in the PCB manufacture process.",
        "keywords": "",
        "authors": [
            {
                "name": "Hu Zhou",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Ning Li",
                "org": ""
            },
            {
                "name": "Jie Zhou",
                "org": ""
            },
            {
                "name": "Xiaoyang Luo",
                "org": ""
            },
            {
                "name": "Jialin Tang",
                "org": ""
            },
            {
                "name": "Xianzhi Qin",
                "org": ""
            }
        ],
        "venue": "Circuit World",
        "year": 2016
    },
    "ERVPQDhU": {
        "id": "ERVPQDhU",
        "title": "Polyurethane membrane with temperature- and pH-Controllable permeability for amino-acids",
        "abstract": "",
        "keywords": [
            "database",
            "chemical engineering",
            "chemistry",
            "chemical",
            "material"
        ],
        "authors": [
            {
                "name": "hu zhou",
                "org": "hunan university of science and technology"
            },
            {
                "name": "ruiping xun",
                "org": "hunan university of science and technology"
            },
            {
                "name": "kejian wu",
                "org": "hunan university of science and technology"
            },
            {
                "name": "zhihua zhou",
                "org": "hunan university of science and technology"
            },
            {
                "name": "bin yu",
                "org": "hunan university of science and technology"
            },
            {
                "name": "youxin tang",
                "org": "hunan university of science and technology"
            },
            {
                "name": "ning li",
                "org": "hunan university of science and technology"
            }
        ],
        "venue": "Macromolecular Research",
        "year": 2014
    },
    "pza7lQbJ": {
        "id": "pza7lQbJ",
        "title": "Synthesis and Characterization of Thermal- and pH-Sensitive Polyurethane Hydrogels with Different Transition Temperature",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hu Zhou",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Jie Zhou",
                "org": ""
            },
            {
                "name": "Jianxian Zeng",
                "org": ""
            },
            {
                "name": "Zhihua Zhou",
                "org": ""
            },
            {
                "name": "Guoqing Liu",
                "org": ""
            }
        ],
        "venue": "Nanoscience and Nanotechnology Letters",
        "year": 2016
    },
    "yLFzmyYe": {
        "id": "yLFzmyYe",
        "title": "Novel Thermal- and pH-Sensitive Polyurethane Hydrogels for Removal of Acid Brilliant Scarlet GR from Aqueous Solutions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hu Zhou",
                "org": ""
            },
            {
                "name": "Yizhi Xiong",
                "org": ""
            },
            {
                "name": "Bin Yu",
                "org": ""
            },
            {
                "name": "Lihua Liu",
                "org": ""
            },
            {
                "name": "Jianxian Zeng",
                "org": ""
            },
            {
                "name": "Zhihua Zhou",
                "org": ""
            },
            {
                "name": "Xuan Liu",
                "org": ""
            },
            {
                "name": "Guoqing Liu",
                "org": ""
            },
            {
                "name": "Qingquan Liu",
                "org": ""
            },
            {
                "name": "Yinchun Jiao",
                "org": ""
            },
            {
                "name": "Jie Zhou",
                "org": ""
            }
        ],
        "venue": "Journal of Biobased Materials and Bioenergy",
        "year": 2017
    },
    "Jh2SvDbV": {
        "id": "Jh2SvDbV",
        "title": "Existence of 2 n positive periodic solutions to n -species nonautonomous food chains with harvesting terms",
        "abstract": "By using Mawhin's continuation theorem of coincidence degree theory and some skills of inequalities, we establish the existence of at least 2 n positive periodic solutions for n -species nonautonomous Lotka-Volterra type food chains with harvesting terms. An example is given to illustrate the effectiveness of our results. © 2010 Y. Li and K. Zhao.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2010
    },
    "adbbsofP": {
        "id": "adbbsofP",
        "title": "On a periodic predator–prey system with time delays on time scales☆",
        "abstract": "With the help of a continuation theorem based on Gaines and Mawhin’s coincidence degree theory, easily verifiable criteria are established for the global existence of positive periodic solutions of the predator–prey system with time delays on time scalesx1Δ(t)=a1(t)-b1(t)exp{x1(t-τ1(t))}-c(t)exp{x2(t-τ2(t))}1+mexp{x1(t)},x2Δ(t)=-a2(t)+b2(t)exp{x1(t-τ2(t))}1+mexp{x1(t-τ2(t))},where ai,bi,c,τi∈C(T,R+),i=1,2 are T-periodic functions.",
        "keywords": [
            "02.30.Ks",
            "05.45.-a",
            "87.23.Cc"
        ],
        "authors": [
            {
                "name": "Jie Liu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2009
    },
    "IbotNIcP": {
        "id": "IbotNIcP",
        "title": "Square-mean almost periodic solution for stochastic Hopfield neural networks with time-varying delays on timescales.",
        "abstract": "In this paper, we first propose a concept of square-mean almost periodic function on timescales. Then, by means of the fixed point theory and differential inequality techniques on timescales, we establish some sufficient conditions on the existence and global exponential stability of square-mean almost periodic solutions for a class of stochastic Hopfield neural networks with time-varying delays on timescales. Our results are new even if the timescale $${\\\\mathbb {T}}={\\\\mathbb {R}}$$T=R or $${\\\\mathbb {Z}}$$Z. Finally, we present an example to illustrate our theoretical results.",
        "keywords": [
            "Stochastic neural networks",
            " Almost periodic solutions",
            " Exponential stability",
            " Timescales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            },
            {
                "name": "Li Yang",
                "org": "School of Statistics and Mathematics,Yunnan University of Finance and Economics,Kunming,People’s Republic of China"
            },
            {
                "name": "Wanqin Wu",
                "org": "School of Mathematics and Computer Science,Yunnan Nationalities University,Kunming,People’s Republic of China"
            }
        ],
        "venue": "Neural Computing and Applications",
        "year": 2015
    },
    "0DX3XDKO": {
        "id": "0DX3XDKO",
        "title": "Infinitely many periodic solutions for second-order (p,q)-Laplacian differential systems",
        "abstract": "Some existence theorems are obtained for infinitely many periodic solutions for second-order (p,q)-Laplacian differential systems by using a general variational principle due to B. Ricceri.",
        "keywords": [
            "(p,q)-Laplacian",
            "Variational method",
            "Periodic solution"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding address: Department of Mathematics, Yunnan University, Cuihu Beilu 2, Kunming, Yunnan 650091, People’s Republic of China. Tel.: +86 08715031199; fax: +86 08715033700."
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2011
    },
    "QGlny6iQ": {
        "id": "QGlny6iQ",
        "title": "Weighted pseudo-almost periodic functions on time scales with applications to cellular neural networks with discrete delays: Y. LI AND L. ZHAO",
        "abstract": "In this paper, we first propose a concept of weighted pseudo-almost periodic functions on time scales and study some basic properties of weighted pseudo-almost periodic functions on time scales. Then, we establish some results about the existence of weighted pseudo-almost periodic solutions to linear dynamic equations on time scales. Finally, as an application of our results, we study the existence and global exponential stability of weighted pseudo-almost periodic solutions for a class of cellular neural networks with discrete delays on time scales. The results of this paper are completely new. Copyright (c) 2016 John Wiley & Sons, Ltd.",
        "keywords": [
            "weighted pesudo-almost periodic solutions",
            "global exponential stability",
            "neural networks",
            "exponential dichotomy",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Lili Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL METHODS IN THE APPLIED SCIENCES",
        "year": 2017
    },
    "C2pIlSqQ": {
        "id": "C2pIlSqQ",
        "title": "Positive periodic solutions of neutral lotka-volterra competition systems on time scales",
        "abstract": "By using a fixed point theorem of strict-set-contraction, some sufficient conditions are obtained for the existence of positive periodic solutions for a periodic neutral Lotka-Volterra competition system on time scales of the form Equation required where ri, aij , bij , c ij ε C(T,R+)(i, j = 1, 2, ⋯ , n) are w-periodic functions, and τij , σ ij ε C(T × Rn,T)(i = 1, 2, ⋯ , n) are !-periodic functions with respect to their first arguments, respectively. © 2011 Academic Publications, Ltd.",
        "keywords": [
            "Neutral Lotka-Volterra system",
            "Positive periodic solution",
            "Strict-set-contraction",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Yan Lei",
                "org": "Kunming Matellurgy College(Kunming Metallurgy College,Kunming Advanced School of Metallurgy,Kunming Inst of Powder Metallurgy),Kunming,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "International Journal of Pure and Applied Mathematics",
        "year": 2011
    },
    "5BYjIGJp": {
        "id": "5BYjIGJp",
        "title": "Global Exponential Stability of Delayed Cohen-Grossberg BAM Neural Networks with Impulses on Time Scales",
        "abstract": "Based on the theory of calculus on time scales, the homeomorphism theory, Lyapunov functional method, and some analysis techniques, sufficient conditions are obtained for the existence, uniqueness, and global exponential stability of the equilibrium point of Cohen-Grossberg bidirectional associative memory (BAM) neural networks with distributed delays and impulses on time scales. This is the first time applying the time-scale calculus theory to unify the discrete-time and continuous-time Cohen-Grossberg BAM neural network with impulses under the same framework.",
        "keywords": [
            "Neural Network",
            " Equilibrium Point",
            " Impulsive Effect",
            " Generalize Exponential Function",
            " Hopfield Neural Network"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,China"
            },
            {
                "name": "Yuchun Hua",
                "org": "Department of Mathematics,Yunnan University,Kunming,China"
            },
            {
                "name": "Yu Fei",
                "org": "School of Statistics and Mathematics,Yunnan University of Finance and Economics,Kunming,China"
            }
        ],
        "venue": "Journal of Inequalities and Applications",
        "year": 2009
    },
    "GT6SCx3w": {
        "id": "GT6SCx3w",
        "title": "Uniformly almost periodic functions and almost periodic solutions to dynamic equations on time scales",
        "abstract": "Firstly, we propose a concept of uniformly almost periodic functions on almost periodic time scales and investigate some basic properties of them. When time scale T = ℝor ℤ, our definition of the uniformly almost periodic functions is equivalent to the classical definitions of uniformly almost periodic functions and the uniformly almost periodic sequences, respectively. Then, based on these, we study the existence and uniqueness of almost periodic solutions and derive some fundamental conditions of admitting an exponential dichotomy to linear dynamic equations. Finally, as an application of our results, we study the existence of almost periodic solutions for an almost periodic nonlinear dynamic equations on time scales. Copyright © 2011 Yongkun Li and Chao Wang.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "University of Yunnan(University of Yunnan,University Yunnan),Kunming,China"
            },
            {
                "name": "Chao Wang",
                "org": "University of Yunnan(University of Yunnan,University Yunnan),Kunming,China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2011
    },
    "tz3AVCyo": {
        "id": "tz3AVCyo",
        "title": "Almost periodic functions on time scales and applications",
        "abstract": "We first propose the concept of almost periodic time scales and then give the definition of almost periodic functions on almost periodic time scales, then by using the theory of calculus on time scales and some mathematical methods, some basic results about almost periodic differential equations on almost periodic time scales are established. Based on these results, a class of high-order Hopfield neural networks with variable delays are studied on almost periodic time scales, and some sufficient conditions are established for the existence and global asymptotic stability of the almost periodic solution. Finally, two examples and numerical simulations are presented to illustrate the feasibility and effectiveness of the results.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Chao Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2011
    },
    "GW5FfIAr": {
        "id": "GW5FfIAr",
        "title": "Multiple Positive Periodic Solutions of a Discrete Time Delayed Predator–Prey System with Harvesting Terms",
        "abstract": "In this paper, by using Mawhin’s continuation theorem of coincidence degree theory, we establish the existence of at least\n two positive periodic solutions for a discrete time delayed predator–prey system with harvesting terms. An example is given\n to illustrate the effectiveness of our results.",
        "keywords": [
            "discrete systems · predator-prey models · coincidence degree · harvesting terms",
            "discrete time",
            "discrete system"
        ],
        "authors": [
            {
                "name": "Xinggui Liu",
                "org": "Department of Applied Mathematics, Yunnan Agricultural University, Kunming, Yunnan, 650201 People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan, 650091 People’s Republic of China"
            },
            {
                "name": "Yaping Ren",
                "org": "Statistics and Mathematics College, Yunnan University of Finance and Economics, Kunming, Yunnan, 650221 People’s Republic of China"
            }
        ],
        "venue": "Differential Equations and Dynamical Systems",
        "year": 2010
    },
    "1a1ZEUQl": {
        "id": "1a1ZEUQl",
        "title": "Existence and exponential stability of periodic solutions for a class of Hamiltonian systems on time scales",
        "abstract": "In this paper, by using a fixed point theorem and the theory of calculus on time scales, we obtain some sufficient conditions for the existence and exponential stability of periodic solutions for a class of Hamiltonian systems on time scales. We also present numerical examples to show the feasibility of our results. The results of this paper are completely new and complementary to the previously known results even if the time scale T = R or Z. © 2013 Yang et al.; licensee Springer.",
        "keywords": [
            "exponential stability",
            "hamiltonian system",
            "periodic solution",
            "time scale"
        ],
        "authors": [
            {
                "name": "Li Yang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Yongzhi Liao",
                "org": "Panzhihua University(Pan-zhihua University,Panzhihua University,Pan Zhihua University),,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2013
    },
    "LwvukDYH": {
        "id": "LwvukDYH",
        "title": "Antiperiodic solutions for a generalized high-order (p, q)-Laplacian neutral differential system with delays in the critical case",
        "abstract": "By applying the method of coincidence degree, some criteria are established for the existence of antiperiodic solutions for a generalized high-order (p, q)-Laplacian neutral differential system with delays (φp((x(t)-cx(t-τ)) (k)))(m-k) = F(t,xθ0(t), xθ1(t) ′,..., xθk(t)(k), yθ0(t), yθ1(t) ′,., yθl(t)(l)), (φq((y(t)-dy(t- σ))(l)))(n-l) = G(t,y0(t), y1(t)′,..., yl(t)(l), x0(t), x1(t) ′,..., xk(t)(k)) in the critical case | c | = | d | = 1. The results of this paper are completely new. Finally, an example is employed to illustrate our results. © 2013 Yongzhi Liao et al.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yongzhi Liao",
                "org": "Panzhihua University(Pan-zhihua University,Panzhihua University,Pan Zhihua University),,China"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Kunming University of Science and Technology(Kunming University of Science and Technology),Kunming,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2013
    },
    "6qzXr1el": {
        "id": "6qzXr1el",
        "title": "Existence and stability of positiveperiodic solution for BAM neural networks with delays",
        "abstract": "In this paper, we use Krasnosel'skii's fixed-point theorem in cones and Lyapunovfunctions to study the existence and stability of a positive periodic solution for a class of two-layer heteroassociative networks called bidirectional associative memory (BAM) networks with state dependent delays dx\"idt=-a\"i(t)x\"i(t)+@?j=1mc\"j\"i(t)f\"j(y\"j(@a\"j\"i(t,y\"j(t))))+I\"i(t),dy\"jdt=-b\"j(t)y\"j(t)+@?i=1nd\"i\"j(t)f\"i(x\"i(@b\"i\"j(t,x\"i(t))))+J\"j(t), where i = 1,2,, n, j =m.",
        "keywords": [
            "bidirectional associative memory",
            "positiveperiodic solution",
            "state dependent delays dx",
            "state dependent delay",
            "positive periodic solution",
            "fixed-point theorem",
            "bam neural networks",
            "two-layer heteroassociative network",
            "differential equation",
            "stability",
            "bam neural network",
            "delay differential equation",
            "fixed point theorem"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Author to whom all correspondence should be addressed at yklie@ynu. edu. cn."
            },
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, P.R. China"
            }
        ],
        "venue": "Mathematical and Computer Modelling",
        "year": 2004
    },
    "ivCSnsNT": {
        "id": "ivCSnsNT",
        "title": "Stability and Hopf Bifurcation Analysis on a Stage-structured Predator-prey System with Time Delays",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "changzhao li",
                "org": ""
            },
            {
                "name": "lili zhao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "qnGBgMrX": {
        "id": "qnGBgMrX",
        "title": "Globally Asymptotic Almost Automorphic Synchronization of Clifford-Valued RNNs With Delays",
        "abstract": "In this paper, we consider a class of Clifford-valued recurrent neural networks (RNNs) with discrete and infinitely distributed delays. In order to overcome the non-commutativity of the multiplication of Clifford numbers, we first transform the Clifford-valued RNNs with discrete and infinitely distributed delays into real-valued systems based on the multiplication rule and properties of Clifford numbers. Then, we establish the existence and uniqueness of almost automorphic solutions for the neural networks under consideration by applying the contraction mapping principle, and we obtain the globally asymptotic almost automorphic synchronization of the neural networks under consideration by designing a novel state feedback controller and constructing an appropriate Lyapunov function. Finally, we present a numerical example to illustrate the feasibility of the results of this paper.",
        "keywords": [
            "Clifford-valued recurrent neural networks",
            "time delay",
            "almost automorphic solution",
            "globally asymptotic synchronization"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Jianglian Xiang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Bing Li",
                "org": "Yunnan Nationalities Univ, Sch Math & Comp Sci, Kunming 650500, Yunnan, Peoples R China"
            }
        ],
        "venue": "IEEE ACCESS",
        "year": 2019
    },
    "yKOoKohV": {
        "id": "yKOoKohV",
        "title": "Synchronisation of generalised stochastic neural networks with delays and reaction-diffusion terms on timescales",
        "abstract": "This paper investigates the synchronisation problem of generalised stochastic neural networks with mixed time-varying delays and reaction-diffusion terms on timescales. Base on Lyapunov stability theory and inequality skills, we establish some sufficient conditions to ensure the global exponential synchronisation of generalised stochastic neural networks with mixed time-varying delays and reaction-diffusion terms on timescales. Finally, we give an example to illustrate the effectiveness of our results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Xiaofang Meng",
                "org": ""
            }
        ],
        "venue": "International Journal of Dynamical Systems and Differential Equations",
        "year": 2015
    },
    "iqBy58DA": {
        "id": "iqBy58DA",
        "title": "Almost Periodic Solutions in Distribution Sense for Quaternion-Valued Stochastic Delayed Neural Networks.",
        "abstract": "In this paper, we consider quaternion-valued stochastic delayed neural networks. We first obtain the existence of almost periodic solutions in distribution sense by employing the contraction mapping principle. Then by using stochastic analysis and inequality techniques, we obtain the mean square global exponential stability of the almost periodic solutions of the considered neural networks. Finally, we present a numerical example to illustrate the feasibility of our results.",
        "keywords": [
            "Almost periodicity in distribution sense",
            "mean square global exponential stability",
            "quaternion-valued stochastic neural network"
        ],
        "authors": [
            {
                "name": "Xiaofang Meng",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "IEEE ACCESS",
        "year": 2020
    },
    "hmybX3Mo": {
        "id": "hmybX3Mo",
        "title": "Almost Automorphic Solutions for Fuzzy Cohen-Grossberg Neural Networks with Mixed Time Delays",
        "abstract": "This paper is concerned with the problem of almost automorphic solutions of a class of fuzzyCohen-Grossberg neural networks with mixed time delays and variable coefficients. Based on inequality analysis techniques and combining the exponential dichotomy with fixed point theorem, some sufficient conditions for the existence and global exponential stability of almost automorphic solutions are obtained. Finally, a numerical example is given to show the feasibility of our results.",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "xiaofang meng",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "xuemei zhang",
                "org": "Qujing Normal Univ, Sch Mathamat & Informat Sci, Qujing 655011, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL PROBLEMS IN ENGINEERING",
        "year": 2015
    },
    "iOivJdWx": {
        "id": "iOivJdWx",
        "title": "Periodic Solutions for a Delayed Predator-Prey System with Harvesting Terms and Holling IV Functional Responses on Time Scales*",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "pan wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "BXJA6e5S": {
        "id": "BXJA6e5S",
        "title": "Almost periodic solutions for a class of discrete systems with Allee-effect",
        "abstract": "In this paper, using Mawhin’s continuation theorem of the coincidence degree theory, we obtain some sufficient conditions for the existence of positive almost periodic solutions for a class of delay discrete models with Allee-effect.",
        "keywords": [
            "discrete system",
            " coincidence degree",
            " almost periodic solution",
            " Allee-effect",
            " 34K14",
            " 92D25"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "li yang",
                "org": "yunnan university"
            },
            {
                "name": "wanqin wu",
                "org": "yunnan nationalities university"
            }
        ],
        "venue": "Applications of Mathematics",
        "year": 2014
    },
    "KYoVlCE6": {
        "id": "KYoVlCE6",
        "title": "On the existence and stability of a unique almost periodic solution of Schoener's competition model with pure-delays and impulsive effects",
        "abstract": "In this paper, we consider an almost periodic Schoener's competition model with delays and impulsive effects. Sufficient conditions which guarantee the permanence of the model and the existence of a unique uniformly asymptotically stable positive almost periodic solution are obtained. The result of this paper is completely new. An suitable example is employed to illustrate the feasibility of the main results. © 2011 Elsevier B.V.",
        "keywords": [
            "Pure-delay",
            "Schoener’s competition model",
            "Almost periodic solution",
            "Impulse"
        ],
        "authors": [
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yuan Ye",
                "org": "Graduate School of Yunnan University, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2012
    },
    "nXrAyHMH": {
        "id": "nXrAyHMH",
        "title": "The global exponential pseudo almost periodic synchronization of quaternion-valued cellular neural networks with time-varying delays.",
        "abstract": "In this paper, we consider the problem of the pseudo almost periodic synchronization of quaternion-valued cellular neural networks (QVCNNs) with time-varying delays. Firstly, we use the Banach fixed point theorem to obtain the existence of pseudo almost periodic solutions of QVCNNs with time varying delays. Then, by designing a novel and very general nonlinear state-feedback controller, and constructing suitable Lyapunov functions, we obtain that the drive-response structure of QVCNNs with pseudo almost periodic coefficients can realize the global exponential synchronization. Our results are completely new. Finally, a numerical example is given to illustrate the feasibility of our results.",
        "keywords": [
            "Pseudo almost periodic solution",
            "Global exponential synchronization",
            "Quaternion-valued neural network",
            "Time delay"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Bing Li",
                "org": "Corresponding author at: Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China."
            },
            {
                "name": "Sisheng Yao",
                "org": "Department of Mathematics, Kunming University, Kunming, Yunnan 650214, People’s Republic of China"
            },
            {
                "name": "Lianglin Xiong",
                "org": "School of Mathematics and Computer Science, Yunnan Nationalities University, Kunming, Yunnan 650500, People’s Republic of China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2018
    },
    "wLAzrX9M": {
        "id": "wLAzrX9M",
        "title": "Global exponential stability of fuzzy interval delayed neural networks with impulses on time scales.",
        "abstract": "In this paper, we investigate the existence and uniqueness of equilibrium point for fuzzy interval delayed neural networks with impulses on time scales. And we give the criteria of the global exponential stability of the unique equilibrium point for the neural networks under consideration using Lyapunov method. Finally, we present an example to illustrate that our results are effective.",
        "keywords": [
            "fuzzy interval neural networks",
            "global exponential stability",
            "impulse",
            "time scale",
            "neural network"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Tianwei Zhang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Int. J. Neural Syst.",
        "year": 2009
    },
    "rIrmwIS5": {
        "id": "rIrmwIS5",
        "title": "EXPONENTIAL CONVERGENCE FOR BAM NEURAL NETWORKS WITH DISTRIBUTED DELAYS",
        "abstract": "This paper concerns the exponential convergence of bidirectional associative memory (BAM) neural networks with unbounded distributed de- lays. Sucient conditions are derived by exploiting the exponentially fading memory property of delay kernel functions. The method is based on compari- son principle of delay dierential equations and does not need the construction of any Lyapunov functions.",
        "keywords": [
            ". bidirectional associative memory networks",
            "san marcos.",
            "exponential convergence. c 2008 texas state university",
            "delay kernels",
            "lyapunov function",
            "kernel function",
            "network delay",
            "bidirectional associative memory"
        ],
        "authors": [
            {
                "name": "YONGKUN LI",
                "org": ""
            },
            {
                "name": "YAPING REN",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "4LqzgU6k": {
        "id": "4LqzgU6k",
        "title": "Existence and stability of periodic solutions for Cohen–Grossberg neural networks with multiple delays",
        "abstract": "We use the continuation theorem of coincidence degree theory and Liapunov functions to study the existence and stability of periodic solutions for the Cohen–Grossberg neural network with multiple delays.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Chaos, Solitons & Fractals",
        "year": 2004
    },
    "1XzmffoN": {
        "id": "1XzmffoN",
        "title": "2n Positive Periodic Solutions to n Species Non-Autonomous Lotka-Volterra Unidirectional Food Chains with Harvesting Terms",
        "abstract": "By using the Mawhin continuation theorem of coincidence degree theory and some results on inequalities, we establish the existence of 2(n) positive periodic solutions for n species non-autonomous Lotka-Volterra unidirectional food chains with harvesting terms. Two examples are given to illustrate the effectiveness of our results.",
        "keywords": [
            "2(n) positive periodic solutions",
            "non-autonomous Lotka-Volterra food chain",
            "coincidence degree",
            "harvesting term"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Kunming Univ Sci & Technol, Dept Appl Math, Kunming 650093, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL MODELLING AND ANALYSIS",
        "year": 2010
    },
    "PcqdDoVp": {
        "id": "PcqdDoVp",
        "title": "The existence and global exponential stability of almost periodic solutions for neutral type CNNs on time scales",
        "abstract": "In this paper, neutral-type competitive neural networks with mixed time-varying delays and leakage delays on time scales are proposed. Based on the contraction fixed-point theorem, some sufficient conditions that are independent of the backwards graininess function of the time scale are obtained for the existence and global exponential stability of almost periodic solutions of neural networks under consideration. The results obtained are brand new, indicating that the continuous time and discrete-time conditions of the network share the same dynamic behavior. Finally, two examples are given to illustrate the validity of the results obtained.",
        "keywords": [
            "competitive neural networks",
            "leakage delays",
            "almost periodic solutions",
            "time scales"
        ],
        "authors": [
            {
                "name": "Bing Li",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650500, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Xiaofang Meng",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICS",
        "year": 2019
    },
    "klvtvMHS": {
        "id": "klvtvMHS",
        "title": "Existence and stability of periodic solutions for a class of generalized nonautonomous neural networks with distributed delays",
        "abstract": "",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Lifei Zhu",
                "org": ""
            },
            {
                "name": "Wenxiang Liu",
                "org": ""
            }
        ],
        "venue": "International Journal of Mathematics and Mathematical Sciences",
        "year": 2005
    },
    "0XqrZZkc": {
        "id": "0XqrZZkc",
        "title": "Multiple Positive Solutions for Second-Order -Laplacian Dynamic Equations with Integral Boundary Conditions",
        "abstract": "We are concerned with the following second-order  Open image in new window -Laplacian dynamic equations on time scales  Open image in new window ,  Open image in new window , with integral boundary conditions  Open image in new window ,  Open image in new window . By using Legget-Williams fixed point theorem, some criteria for the existence of at least three positive solutions are established. An example is presented to illustrate the main result.",
        "keywords": [
            "Dynamic Equation",
            " Existence Result",
            " Fixed Point Theorem",
            " Heat Transfer",
            " Epidemic Model"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "tianwei zhang",
                "org": "yunnan university"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2010
    },
    "1cRJMedv": {
        "id": "1cRJMedv",
        "title": "Anti-Periodic Solutions for a Class of Neural Networks with Variable and Unbounded Time Delays",
        "abstract": "A class of neural networks with variable and unbounded time delays is considered.Sufficient conditions for the existence and exponential stability of anti-periodic solutions are established,which are new and complement previously the known results.",
        "keywords": [
            "exponential stability",
            "delays",
            "neural networks",
            "anti-periodic solution"
        ],
        "authors": [
            {
                "name": "SONG Jiang-yan",
                "org": "Department of Mathematics,Yunnan University,Kunming 65009,China"
            },
            {
                "name": "LIU Ping",
                "org": "Department of Mathematics,Yunnan University,Kunming 65009,China"
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming 65009,China"
            }
        ],
        "venue": "Journal of Jishou University(Natural Sciences Edition)",
        "year": 2009
    },
    "QyXn1kKr": {
        "id": "QyXn1kKr",
        "title": "Pseudo almost periodic solutions for neutral type high-order Hopfield neural networks with mixed time-varying delays and leakage delays on time scales",
        "abstract": "We propose a class of neutral type high-order Hopfield neural networks with mixed time-varying delays and leakage delays on time scales. Applying the exponential dichotomy of linear dynamic equations on time scales, Banach’s fixed point theorem and theory of calculus on time scales, we obtain several sufficient conditions to ensure the existence and global exponential stability of pseudo almost periodic solutions of the proposed neural networks. Finally, we illustrate the effectiveness of the obtained results with an example. The example also shows that the continuous-time neural network and its discrete-time analogue have the same dynamical behaviors when considering the pseudo almost periodicity.",
        "keywords": [
            "Hopfield neural networks",
            " Mixed time-varying delays",
            " Leakage delays",
            " Pseudo almost periodic solutions",
            " Time scales"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            },
            {
                "name": "xiaofang meng",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            },
            {
                "name": "lianglin xiong",
                "org": "School of Mathematics and Computer Science,Yunnan Minzu University,Kunming,People’s Republic of China"
            }
        ],
        "venue": "Int. J. Machine Learning & Cybernetics",
        "year": 2015
    },
    "323zZr5f": {
        "id": "323zZr5f",
        "title": "Multiple positive periodic solutions for a non-autonomous stage-structured predatory-prey system with harvesting terms",
        "abstract": "This paper is concerned with a non-autonomous stage-structured predator-prey model with harvesting terms. By means of the coincidence degree theory, we establish the existence of at least eight positive periodic solutions for the system under consideration. An example is given to illustrate the effectiveness of our results.",
        "keywords": [
            "Positive periodic solutions",
            "Stage-structured predatory-prey system",
            "Coincidence degree",
            "Harvesting term"
        ],
        "authors": [
            {
                "name": "Zhouhong Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "zqGrWL4Y": {
        "id": "zqGrWL4Y",
        "title": "Antiperiodic Solutions for Quaternion-Valued Shunting Inhibitory Cellular Neural Networks with Distributed Delays and Impulses.",
        "abstract": "This paper is concerned with quaternion-valued shunting inhibitory cellular neural networks (QVSICNNs) with distributed delays and impulses. By using a new continuation theorem of the coincidence degree theory, the existence of antiperiodic solutions for QVSICNNs is obtained. By constructing a suitable Lyapunov function, some sufficient conditions are derived to guarantee the global exponential stability of antiperiodic solutions for QVSICNNs. Finally, an example is given to show the feasibility of obtained results.",
        "keywords": "",
        "authors": [
            {
                "name": "Nina Huo",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "COMPLEXITY",
        "year": 2018
    },
    "RWCbQlDJ": {
        "id": "RWCbQlDJ",
        "title": "Existence and multiplicity of solutions for a class of damped vibration problems with impulsive effects",
        "abstract": "Some sufficient conditions on the existence and multiplicity of solutions for the damped vibration problems with impulsive effects {u \"(t) + g(t)u'(t) + f(t,u(t)) =0(,) a.e. t is an element of [0,T], u(0) = t(T) = 0, Delta u'(t(j)) = u'(t(j)(+)) - u'(t(j)(-)) = I-j(u(t(j))), j= 1, ... ,p, are established, where t(0) = 0 < t(1) < ... < tp < t(p+1) = T,g is an element of L-1 (0,T;R), f: [0, T] x R -> R is continuous, and I-j : R -> R, j = 1, ... ,p, are continuous. The solutions are sought by means of the Lax-Milgram theorem and some critical point theorems. Finally, two examples are presented to illustrate the effectiveness of our results.",
        "keywords": [
            "damped vibration problems",
            "impulse",
            "Lax-Milgram theorem",
            "critical points"
        ],
        "authors": [
            {
                "name": "Jianwen Zhou",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "ANNALES POLONICI MATHEMATICI",
        "year": 2011
    },
    "rLQ6A4fc": {
        "id": "rLQ6A4fc",
        "title": "Global Asymptotic Almost Periodic Synchronization of Clifford-Valued CNNs with Discrete Delays.",
        "abstract": "In this paper, we are concerned with Clifford-valued cellular neural networks (CNNs) with discrete delays. Since Clifford algebra is a unital associative algebra and its multiplication is noncommutative, to overcome the difficulty of the noncommutativity of the multiplication of Clifford numbers, we first decompose the considered Clifford-valued neural network into 2m2n real-valued systems. Second, based on the Banach fixed point theorem, we establish the existence and uniqueness of almost periodic solutions of the considered neural networks. Then, by designing a novel state-feedback controller and constructing a proper Lyapunov function, we study the global asymptotic synchronization of the considered neural networks. Finally, a numerical example is presented to show the effectiveness and feasibility of our results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Jianglian Xiang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "COMPLEXITY",
        "year": 2019
    },
    "SAcS5LM6": {
        "id": "SAcS5LM6",
        "title": "Positive periodic solutions of functional differential equations with impulses and a parameter",
        "abstract": "By applying the well-known Leggett-Williams multiple fixed point theorem, this paper investigates the existence of multiple positive periodic solutions of functional differential equations with impulses and a parameter.",
        "keywords": [
            "cone",
            "functional differential equation",
            "multiple fixed point theorem",
            "periodic solution",
            "impulses",
            "multiple positive periodic solution",
            "leggett–williams fixed point",
            "well-known leggett-williams",
            "fixed point theorem",
            "fixed point"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Xuanlong Fan",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Computers & Mathematics with Applications",
        "year": 2008
    },
    "cpY65svn": {
        "id": "cpY65svn",
        "title": "Positive periodic solutions for a neutral Lotka–Volterra system with state dependent delays☆",
        "abstract": "By using a fixed point theorem of strict-set-contraction, some new criteria are established for the existence of positive periodic solutions of the following periodic neutral Lotka–Volterra system with state dependent delaysdxi(t)dt=xi(t)ri(t)-∑j=1naij(t)xj(t)+∑j=1nbij(t)xj(t-τij(t,x1(t),…,xn(t)))+∑j=1ncij(t)xj′(t-σij(t,x1(t),…,xn(t))),i=1,2,…,n,where ri,aij∈C(R,R+),bij,cij∈C(R,R)(i,j=1,2,…,n) are ω-periodic functions and τij,σij∈C(Rn+1,R)(i,j=1,2,…,n) are ω-periodic functions with respect to their first arguments, respectively.",
        "keywords": [
            "02.30.Ks"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2009
    },
    "fwWrr0BI": {
        "id": "fwWrr0BI",
        "title": "Classifications and existence of positive solutions of higher-order nonlinear neutral differential equations",
        "abstract": "In this paper, necessary and sufficient conditions for the existence and classification of positive solutions of the higher order neutral differential equationr(t)x(t)-@?\\\"i\\\"=\\\"1^mP\\\"i(t)x(t-@t\\\"i)^(^n^-^1^)^'+ft,x(t-@s\\\"1),...,x(t-@s\\\"l)=0are obtained, where P\\\"i(t)=0, i=1,...,m, f(t,@m\\\"1,...,@m\\\"l)@?C([t\\\"0,~)xR^l,R).",
        "keywords": [
            "existence",
            "fixed point",
            "neutral differential equation",
            "positive solution",
            "higher order",
            "fixed point theorem",
            "difference equation"
        ],
        "authors": [
            {
                "name": "Zigen Ouyang",
                "org": "Department of Mathematics, Nanhua University, Hengyang, Hunan 421001, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Qingan Tang",
                "org": "Department of Mathematics, Guilin Electronic Industry College, Guilin, Guangxi 545004, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2004
    },
    "hFMhkuCD": {
        "id": "hFMhkuCD",
        "title": "Positive periodic solutions of functional differential equations with impulse on time scales",
        "abstract": "In this paper, we employ some analysis technics to study the existence of positive periodic solutions to a system of equations\n with a parameter and impulse on time scales.",
        "keywords": [
            "functional differential equation · time scale · positive periodic solution",
            "Functional differential equation",
            "Time scale",
            "Positive periodic solution",
            "34K13",
            "34K45"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Lu Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Xuerong Chen",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2010
    },
    "dxcABvul": {
        "id": "dxcABvul",
        "title": "Almost periodic solutions for quaternion-valued shunting inhibitory cellular neural networks of neutral type with time delays in the leakage term.",
        "abstract": "ABSTRACTIn this paper, we propose a class of quaternion-valued shunting inhibitory cellular neural networks of neutral type with time delays in the leakage term. In order to overcome the difficulty of the non-commutativity of quaternion multiplication, we first decompose the system under consideration into four real-valued systems. Then by using the exponential dichotomy theory of linear differential equations and Banachu0027s fixed point theorem, we establish sufficient conditions to ensure the existence and global exponential stability of almost periodic solutions for this class of neural networks. Finally, a numerical example is given to demonstrate the effectiveness of the obtained result.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": " Department of Mathematics, Yunnan University, Kunming, Yunnan, Peoples' Republic of China"
            },
            {
                "name": "Xiaofang Meng",
                "org": " Department of Mathematics, Yunnan University, Kunming, Yunnan, Peoples' Republic of China"
            }
        ],
        "venue": "Int. J. Systems Science",
        "year": 2018
    },
    "5A4ZGaTr": {
        "id": "5A4ZGaTr",
        "title": "Existence and Global Exponential Stability of almost Periodic Solutions for BAM Neural Networks with variable Coefficients on Time Scales",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "chao wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "JHep0Bui": {
        "id": "JHep0Bui",
        "title": "Mean-Square Almost Periodic Solutions for Impulsive Stochastic Host-Macroparasite Equation on Time Scales",
        "abstract": "We consider an impulsive stochastic host-macroparasite equation on time scales. By use of the Banach fixed point theorem and Gronwall-Bellman's inequality technique on time scales, we obtain the existence and exponential stability of mean-square almost periodic solutions for the host-macroparasite equation on time scales. Finally, we give an example to illustrate the feasibility of our results.",
        "keywords": [],
        "authors": [
            {
                "name": "pan wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "qingmei lin",
                "org": "Yunnan Univ, Sch Math, Wenshan 650091, Yunnan, Peoples R China"
            },
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2015
    },
    "1pCuRAOj": {
        "id": "1pCuRAOj",
        "title": "Anti-periodic solutions to impulsive shunting inhibitory cellular neural networks with distributed delays on time scales",
        "abstract": "By using the method of coincidence degree and constructing suitable Lyapunov functional, several sufficient conditions are established for the existence and global exponential stability of anti-periodic solutions to impulsive shunting inhibitory cellular neural networks with distributed delays on time scale T. Our results are new even if the time scale T=R or Z. An example is given to illustrate our feasible results. © 2010 Elsevier B.V.",
        "keywords": [
            "Anti-periodic solution",
            "Global exponential stability",
            "Shunting inhibitory cellular neural networks",
            "Impulse",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Jiangye Shu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2011
    },
    "38JN2aeK": {
        "id": "38JN2aeK",
        "title": "Positive periodic solutions of infinite delay functional differential equations depending on a parameter",
        "abstract": "In this paper, we employ the upper and lower solutions method to study the existence of positive periodic solutions to a system of infinite delay equations with a parameter x ̇ (t)=A(t)x(t)+λf(t,x t ).",
        "keywords": [
            "Upper and lower solutions method",
            "Positive periodic solution",
            "Cone",
            "Completely continuous",
            "Infinite delay"
        ],
        "authors": [
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2004
    },
    "md8SF7QV": {
        "id": "md8SF7QV",
        "title": "Positive solutions of three-point boundary value problem for second order differential equations with an advanced argument",
        "abstract": "By using the Krasnoselskii’s fixed point theorem for cones, conditions for the existence of positive solutions to the three-point\n boundary value problem for second order differential equation with an advanced argument \n \n \n \n \n $$\\begin{gathered} u''\\left( t \\right) + \\lambda a\\left( t \\right)f\\left( {u\\left( {h\\left( t \\right)} \\right)} \\right) = 0,t \\in \\left( {0,1} \\right), \\hfill \\\\ u\\left( 0 \\right) = 0, \\alpha u\\left( \\eta \\right) = u\\left( 1 \\right) \\hfill \\\\ \\end{gathered} $$\n \n \n \n \n \n , where \n $$0 < \\eta < 1,0 < \\alpha < \\frac{1}{\\eta }$$\n and t⩽h(t)⩽1 are obtained.",
        "keywords": [
            "34K10",
            "three-point boundary value problem",
            "positive solution",
            "fixed point theorem"
        ],
        "authors": [
            {
                "name": "Lifei Zhu",
                "org": "Yunnan Univ. Dept. of Math. 650091 Yunnan China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ. Dept. of Math. 650091 Yunnan China"
            }
        ],
        "venue": "Applied Mathematics-a Journal of Chinese Universities Series B",
        "year": 2003
    },
    "0AoTZ5SE": {
        "id": "0AoTZ5SE",
        "title": "Existence and Exponential Stability of Equilibrium Point for Fuzzy BAM Neural Networks with Infinitely Distributed Delays and Impulses on Time Scales.",
        "abstract": "By using the fixed point theorem and constructing a Lyapunov functional, we establish some sufficient conditions on the existence, uniqueness, and exponential stability of equilibrium point for a class of fuzzy BAM neural networks with infinitely distributed delays and impulses on time scales. We also present a numerical example to show the feasibility of obtained results. Our example also shows that the described time and continuous neural time networks have the same dynamic behaviours for the stability.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Lijie Sun",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Li Yang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF APPLIED MATHEMATICS",
        "year": 2014
    },
    "FQgy0oe8": {
        "id": "FQgy0oe8",
        "title": "SIGN-CHANGING SOLUTIONS FOR A CLASS OF DAMPED VIBRATION PROBLEMS WITH IMPULSIVE EFFECTS",
        "abstract": "",
        "keywords": [
            "impulse",
            "critical points"
        ],
        "authors": [
            {
                "name": "jianwen zhou",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "yanning wang",
                "org": ""
            }
        ],
        "venue": "Taiwanese Journal of Mathematics",
        "year": 2014
    },
    "twKK7mli": {
        "id": "twKK7mli",
        "title": "Almost automorphic solution of quaternion-valued BAM neural networks with time-varying delays on time scales.",
        "abstract": "In this paper, a class of quaternion-valued BAM neural networks with time-varying delays on time scales is proposed. Based on inequality analysis techniques on time scales, a fixed point theorem and the theory of calculus on time scales, the existence and global exponential stability of almost automorphic solutions for this class of neural networks is established. The obtained results are completely new and supplement to the known results. Finally, a numerical example is given to illustrate the feasibility of our results.",
        "keywords": [
            "BAM neural networks",
            "Almost automorphic solution",
            "Quaternion",
            "Global exponential stability",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Shiping Shen",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF INTELLIGENT & FUZZY SYSTEMS",
        "year": 2019
    },
    "QIpxbiTK": {
        "id": "QIpxbiTK",
        "title": "Existence of periodic solutions for neutral type cellular neural networks with delays",
        "abstract": "In this paper, by using the theory of abstract continuation theorem of k contractive operator, we study the existence of periodic solutions for neutral type cellular neural networks with delays.",
        "keywords": [
            "Neutral-type neural networks",
            "Periodic solutions",
            "k-Set contractive",
            "Lyapunov function"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Lu Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Xuerong Chen",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2012
    },
    "hJw628jg": {
        "id": "hJw628jg",
        "title": "Positive periodic solutions of periodic neutral Lotka–Volterra system with distributed delays",
        "abstract": "By using a fixed point theorem of strict-set-contraction, some criteria are established for the existence of positive periodic solutions of the following periodic neutral Lotka–Volterra system with distributed delaysdxi(t)dt=xi(t)ai(t)-∑j=1nbij(t)∫-Tij0Kij(θ)xj(t+θ)dθ-∑j=1ncij(t)∫-Tˆij0Kˆij(θ)xj′(t+θ)dθ,i=1,2,…,n,where ai,bij,cij∈C(R,R+) (i, j=1,2,…,n) are ω-periodic functions, Tij,Tˆij∈(0,∞) (i, j=1,2,…,n) and Kij,Kˆij∈(R,R+) satisfying ∫-Tij0Kij(θ)dθ=1,∫-Tˆij0Kˆij(θ)dθ=1, i, j=1,2,…,n.",
        "keywords": [
            "fixed point theorem",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Chaos, Solitons & Fractals",
        "year": 2008
    },
    "WyFY3LdW": {
        "id": "WyFY3LdW",
        "title": "Almost periodic solution for neutral functional dynamic equations with Stepanov-almost periodic terms on time scales",
        "abstract": "We first propose a concept of almost periodic functions in the sense of Stepanov on time scales. Then, we consider a class of neutral functional dynamic equations with Stepanov-almost periodic terms on time scales in a Banach space. By means of the contraction mapping principle, we establish some criteria for the existence and uniqueness of almost periodic solutions for this class of dynamic equations on time scales. Finally, we give an example to illustrate the effectiveness of our results.",
        "keywords": [
            "Neutral functional dynamic equation",
            "Stepanov-almost periodic function",
            "the contraction mapping principle",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Pan Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES S",
        "year": 2017
    },
    "LeQihfCf": {
        "id": "LeQihfCf",
        "title": "Positive periodic solutions of nonlinear functional differential equations",
        "abstract": "We apply the generalized form of Leggett–Williams fixed point theorem to prove that the following nonlinear functional differential equation x ′ (t)=−a(t)x(t)+f(t,x t ) has at least two positive T -periodic solutions, where a ( t ) is a T -periodic function satisfying exp (∫ 0 T a(u) d u)>1 , f ( t , x t ) is a nonnegative function defined on R × BC , where BC denotes the Banach space of bounded continuous functions.",
        "keywords": [
            "banach space",
            "fixed point theorem",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            },
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            }
        ],
        "venue": "微分方程年刊(英文版)",
        "year": 2006
    },
    "PyBQsOtc": {
        "id": "PyBQsOtc",
        "title": "Global Exponential Stability for Impulsive BAM Neural Networks with Distributed Delays on Time Scales",
        "abstract": "In this paper, by utilizing the time scale calculus theory, topological degree theory and Hölder's inequality on time scales, we analyze a class of impulsive BAM neural networks with distributed delays on time scales. Some sufficient conditions are obtained to ensure the existence, uniqueness and the global exponential stability of the equilibrium point. Finally, an example is provided to demonstrate the effectiveness of the results.",
        "keywords": [
            "Global exponential stability",
            "BAM neural network",
            "Impulsive",
            "Distributed delays",
            "Time scale",
            "Topological degree theory"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Yunnan, Kunming, People's Republic of China 650091"
            },
            {
                "name": "Shan Gao",
                "org": "Department of Mathematics, Yunnan University, Yunnan, Kunming, People's Republic of China 650091"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2010
    },
    "TLazuFsZ": {
        "id": "TLazuFsZ",
        "title": "Almost automorphic solutions for neutral type CNNs with time-varying delays and $D$ operator on time scales",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Li",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            }
        ],
        "venue": "Tbilisi Mathematical Journal",
        "year": 2019
    },
    "by926Ibw": {
        "id": "by926Ibw",
        "title": "Global exponential stability and existence of anti-periodic solutions to impulsive Cohen-Grossberg neural networks on time scales",
        "abstract": "",
        "keywords": [
            "impulse"
        ],
        "authors": [
            {
                "name": "tianwei zhang",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "Topological Methods in Nonlinear Analysis",
        "year": 2015
    },
    "zMKXY5dJ": {
        "id": "zMKXY5dJ",
        "title": "Almost Automorphic Functions on the Quantum Time Scale and Applications",
        "abstract": "We first propose two types of concepts of almost automorphic functions on the quantum time scale. Secondly, we study some basic properties of almost automorphic functions on the quantum time scale. Then, we introduce a transformation between functions defined on the quantum time scale and functions defined on the set of generalized integer numbers; by using this transformation we give equivalent definitions of almost automorphic functions on the quantum time scale; following the idea of the transformation, we also give a concept of almost automorphic functions on more general time scales that can unify the concepts of almost automorphic functions on almost periodic time scales and on the quantum time scale. Finally, as an application of our results, we establish the existence of almost automorphic solutions of linear and semilinear dynamic equations on the quantum time scale.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2017
    },
    "EOcyo8U0": {
        "id": "EOcyo8U0",
        "title": "Exponential stability of periodic solution for shunting inhibitory CNNs with delays",
        "abstract": "By means of suitable Lyapunov functionals,the exponential stability of periodic solutions for shunting inhibitory cellular neural networks(SICNNs)with delays and variable coefficients is studied.",
        "keywords": [
            "periodic solution",
            "exponential stability",
            "Lyapunov functionals",
            "SICNNs"
        ],
        "authors": [
            {
                "name": "LIU Chun-chao",
                "org": "Department of Mathematics,Huanggang Normal College,Huanggang ,China"
            },
            {
                "name": "PENG Jin",
                "org": "Department of Mathematics,Huanggang Normal College,Huanggang ,China"
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            }
        ],
        "venue": "Pure and Applied Mathematics",
        "year": 2005
    },
    "MSa2Qrxg": {
        "id": "MSa2Qrxg",
        "title": "Permanence and almost periodic solution of a multispecies Lotka-Volterra mutualism system with time varying delays on time scales",
        "abstract": "In this paper, we consider the almost periodic dynamics of a multispecies Lotka-Volterra mutualism system with time varying delays on time scales. By establishing some dynamic inequalities on time scales, a permanence result for the model is obtained. Furthermore, by means of the almost periodic functional hull theory on time scales and Lyapunov functional, some criteria are obtained for the existence, uniqueness and global attractivity of almost periodic solutions of the model. Our results complement and extend some scientific work in recent years. Finally, an example is given to illustrate the main results.",
        "keywords": [
            "permanence",
            " almost periodic solution",
            " mutualism system",
            " time delay",
            " time scale"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "pan wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2015
    },
    "OYE6nnOK": {
        "id": "OYE6nnOK",
        "title": "Almost periodic solutions for neutral-type neural networks with the delays in the leakage term on time scales",
        "abstract": "In this paper, a class of neutral-type neural networks with delays in the leakage term on time scales are considered. By using the Banach fixed point theorem and the theory of calculus on time scales, some sufficient conditions are obtained for the existence and exponential stability of almost periodic solutions for this class of neural networks. The results of this paper are new and complementary to the previously known results. Finally, an example is presented to illustrate the effectiveness of our results. Copyright (C) 2016 John Wiley & Sons, Ltd.",
        "keywords": [
            "almost periodic solution",
            "global exponential stability",
            "neural networks",
            "time scales"
        ],
        "authors": [
            {
                "name": "Pan Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yuan Ye",
                "org": "Yunnan Univ, Grad Sch, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL METHODS IN THE APPLIED SCIENCES",
        "year": 2016
    },
    "626RR8r5": {
        "id": "626RR8r5",
        "title": "Multiple positive periodic solutions of n species delay competition systems with harvesting terms",
        "abstract": "This paper considers a delay nonautonomous Lotka–Volterra type multispecies competitive system with harvesting terms. The model has the intraspecific competition terms defined by functions which depend on population densities. An existence theorem of 2n positive periodic solutions is established by using the coincidence degree theory. An example is given to illustrate the effectiveness of our result.",
        "keywords": [
            "Positive periodic solutions",
            "Delay competition system",
            "Coincidence degree",
            "Harvesting term"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yuan Ye",
                "org": "Graduate School of Yunnan University, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2011
    },
    "kPWH0wiY": {
        "id": "kPWH0wiY",
        "title": "Existence and Global Exponential Stability of Pseudo Almost Periodic Solution for Clifford- Valued Neutral High-Order Hopfield Neural Networks With Leakage Delays",
        "abstract": "In this paper, we are concerned with a class of Clifford-valued neutral high-order Hopfield neural networks with leakage delays. Although the multiplication of Clifford numbers does not satisfy the commutativity, which brings great difficulties to the study of Clifford-valued systems, we have found a method that does not decompose Clifford-valued systems into real-valued systems to study the existence and global exponential stability of pseudo-almost periodic solutions of this class of neural networks. Our results are completely new. Finally, two examples are given to illustrate the effectiveness and feasibility of our main results.",
        "keywords": [
            "Neural networks",
            "Control theory",
            "Stability",
            "Delays",
            "Vehicle dynamics",
            "Algebra",
            "Licenses",
            "Clifford-valued neural network",
            "neutral high-order Hopfield neural network",
            "pseudo almost periodic solution",
            "global exponential stability",
            "leakage delay"
        ],
        "authors": [
            {
                "name": "Bing Li",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650500, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "IEEE ACCESS",
        "year": 2019
    },
    "nN3GEkSx": {
        "id": "nN3GEkSx",
        "title": "Global Exponential Stability and Existence of Periodic Solution of Impulsive Cohen---Grossberg Neural Networks with Distributed Delays on Time Scales",
        "abstract": "On time scales, by using the continuation theorem of coincidence degree theory, M-matrix theory and constructing some suitable Lyapunov functions, some sufficient conditions are obtained for the existence and exponential stability of periodic solutions of impulsive Cohen---Grossberg neural networks with distributed delays, which are new and complement of previously known results. Finally, an example is given to illustrate the effectiveness of our main results.",
        "keywords": [
            "time scales",
            "coincidence degree theory",
            "impulsive cohen",
            "sufficient condition",
            "cohen-grossberg neural networks · stability · periodic solutions · time scales",
            "grossberg neural network",
            "continuation theorem",
            "periodic solution",
            "grossberg neural networks",
            "main result",
            "suitable lyapunov function",
            "exponential stability",
            "m-matrix theory",
            "global exponential stability",
            "matrix theory",
            "lyapunov function"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            },
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2011
    },
    "2wQzrktH": {
        "id": "2wQzrktH",
        "title": "Weighted pseudo-almost periodic functions on time scales with applications to cellular neural networks with discrete delays",
        "abstract": "In this paper, we first propose a concept of weighted pseudo-almost periodic functions on time scales and study some basic properties of weighted pseudo-almost periodic functions on time scales. Then, we establish some results about the existence of weighted pseudo-almost periodic solutions to linear dynamic equations on time scales. Finally, as an application of our results, we study the existence and global exponential stability of weighted pseudo-almost periodic solutions for a class of cellular neural networks with discrete delays on time scales. The results of this paper are completely new. Copyright (c) 2016 John Wiley & Sons, Ltd.",
        "keywords": [
            "weighted pesudo-almost periodic solutions",
            "global exponential stability",
            "neural networks",
            "exponential dichotomy",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Lili Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL METHODS IN THE APPLIED SCIENCES",
        "year": 2017
    },
    "6t3CoOjB": {
        "id": "6t3CoOjB",
        "title": "Positive almost periodic solution for Nicholson's blowflies models on time scales",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "bing li",
                "org": ""
            },
            {
                "name": "li yang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "I4RHxDdn": {
        "id": "I4RHxDdn",
        "title": "Analysis on Permanence of Impulsive Type Competitive Model of Enterprise Cluster with Feedback Control",
        "abstract": "According to some similarities between species population and enterprise cluster,and basedon the competitive model of species population from ecology,an impulsive type competitive model of enterprise cluster with feedback control was established to describe dynamically the competitive relation of enterprise cluster under net model.By applying the method of comparison theorem,we obtained some sufficient conditions to ensure the permanence of the system and make an economic explanation to the theoretical result.",
        "keywords": [
            "feedback control",
            "enterprise cluster",
            "competitive model",
            "permanence",
            "impulse"
        ],
        "authors": [
            {
                "name": "LIU Ping",
                "org": "Department of Mathematics,Yunnan University,Kunming,Yunnan ,China"
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Journal of Quantitative Economics",
        "year": 2011
    },
    "ViGuSkyq": {
        "id": "ViGuSkyq",
        "title": "A note on linearized oscillations for even order neutral delay differential equations",
        "abstract": "",
        "keywords": [
            "delay differential equation",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Guitong Xu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2000
    },
    "yBm4rUIy": {
        "id": "yBm4rUIy",
        "title": "The Existence and Global Exponential Stability of ({varvec{mu }})-Pseudo Almost Periodic Solutions of Clifford-Valued Semi-linear Delay Differential Equations and an Application",
        "abstract": "In this paper, we consider Clifford-valued semi-linear delay differential equations. Without decomposing the considered differential equations into real-valued equations, we first transform the Clifford-valued differential equations into their equivalent integral equations. Then, by using the Banach fixed point theorem and inequality techniques, we obtain sufficient conditions to ensure the existence and global exponential stability of $$\\mu $$-pseudo almost periodic solutions for the Clifford-valued differential equations under consideration. Finally, as an application of our proposed method, we study the existence and global exponential stability of $$\\mu $$-pseudo almost periodic solutions of Clifford-valued recurrent neural networks. Our methods and results are new.",
        "keywords": [
            "Clifford algebra",
            " Semi-linear delay differential equations",
            " \n\n\n\n-Pseudo almost periodic solutions",
            " Primary 34K14",
            " Secondary 34K20"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Yaolu Wang",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Bing Li",
                "org": "School of Mathematics and Computer Science, Yunnan Minzu University, Kunming, People’s Republic of China"
            }
        ],
        "venue": "Advances in Applied Clifford Algebras",
        "year": 2019
    },
    "QAdSRSSd": {
        "id": "QAdSRSSd",
        "title": "Existence and multiplicity of solutions for a class of damped vibration problems with impulsive effects",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "jianwen zhou",
                "org": ""
            }
        ],
        "venue": "Annales Polonici Mathematici",
        "year": 2011
    },
    "kk4Jhw77": {
        "id": "kk4Jhw77",
        "title": "Anti-Periodic Dynamics of Quaternion-Valued Fuzzy Cellular Neural Networks with Time-Varying Delays on Time Scales",
        "abstract": "A class of quaternion-valued fuzzy cellular neural networks with time-varying delays on time scales is proposed. Based on inequality analysis techniques on time scales, a fixed point theorem and the theory of calculus on time scales, the existence, and global exponential stability of anti-periodic solutions for this class of neural networks are established. The obtained results are completely new and supplement to the known results. Finally, a numerical example is given to illustrate the feasibility of our results.",
        "keywords": "",
        "authors": [
            {
                "name": "Shiping Shen",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Bing Li",
                "org": "Yunnan Nationalities Univ, Sch Math & Comp Sci, Kunming 650500, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2018
    },
    "iwA45zGn": {
        "id": "iwA45zGn",
        "title": "Existence uniqueness and globally exponential stability of anti-periodic solution for a class of recurrent neural networks on time scales",
        "abstract": "This work use the continuation theorem of coincidence degree theory,M-matrix theory to study the existence,uniqueness and exponential stability of anti-periodic solutions of a class of impulsive recurrent neural networks with distributed delayson time scales.Finally,an example is given to illustrate the effectiveness of main results.",
        "keywords": [
            "exponential stability",
            "M-matrix",
            "distributed delay.",
            "coincidence degree",
            "anti-periodic solution",
            "recurrent neural networks"
        ],
        "authors": [
            {
                "name": "ZHAO Li-li",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            }
        ],
        "venue": "Journal of Yunnan University(Natural Sciences Edition)",
        "year": 2011
    },
    "rsCTrMz3": {
        "id": "rsCTrMz3",
        "title": "Weighted pseudo-almost automorphic solutions of high-order Hopfield neural networks with neutral distributed delays.",
        "abstract": "In this paper, a class of high-order Hopfield neural networks with neutral distributed delays is considered. Some sufficient conditions are obtained for the existence, uniqueness and global exponential stability of weighted pseudo-almost automorphic solutions for this class of networks by employing the Banach fixed-point theorem and differential inequality techniques. The results of this paper are completely new. An example is given to show the effectiveness of the proposed method and results.",
        "keywords": [
            "High-order Hopfield neural networks",
            " Neutral distributed delays",
            " Weighted pseudo-almost automorphic solution",
            " Global exponential stability",
            " Fixed-point theorem"
        ],
        "authors": [
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Bing Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            }
        ],
        "venue": "Neural Computing and Applications",
        "year": 2018
    },
    "b7RwWyRC": {
        "id": "b7RwWyRC",
        "title": "Robust stability analysis of fuzzy neural network with delays",
        "abstract": "We investigate local robust stability of fuzzy neural networks (FNNs) with time-varying and S-type distributed delays. We derive some sufficient conditions for local robust stability of equilibrium points and estimate attracting domains of equilibrium points except unstable equilibrium points. Our results not only show local robust stability of equilibrium points but also allow much broader application for fuzzy neural network with or without delays. An example is given to illustrate the effectiveness of our results. Copyright (C) 2009 K. Zhao and Y. Li.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL PROBLEMS IN ENGINEERING",
        "year": 2009
    },
    "fUdnPh30": {
        "id": "fUdnPh30",
        "title": "Existence and uniqueness of anti-periodic solution for a kind of forced Rayleigh equation with state dependent delay and impulses☆",
        "abstract": "By using the method of coincidence degree, some criteria are established for the existence and uniqueness of anti-periodic solution for a kind of forced Rayleigh equation with state dependent delay and impulses. An example is given to illustrate our results.",
        "keywords": [
            "Anti-periodic solution",
            "Rayleigh equation",
            "State dependent delay",
            "Impulse",
            "Coincidence degree"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "k1QBQo7W": {
        "id": "k1QBQo7W",
        "title": "Existence and global exponential stability of periodic solutions for quaternion-valued cellular neural networks with time-varying delays.",
        "abstract": "In this paper, a class of quaternion-valued cellular neural networks (QVCNNs) with time-varying delays is considered. By using the continuation theorem of Mawhin’s coincidence degree theory, the existence of periodic solutions for QVCNNs is obtained. By constructing a suitable Lyapunov function, some sufficient conditions are derived to guarantee the global exponential stability of periodic solutions for QVCNNs. Finally, two examples are given to illustrate the effectiveness of the obtained results.",
        "keywords": [
            "Cellular neural networks",
            "Quaternion",
            "Global exponential stability",
            "Periodic solution",
            "Time-varying delays"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Jiali Qin",
                "org": "Department of MathematicsYunnan UniversityKunmingYunnan650091People’s Republic of China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2018
    },
    "PDk6yI0H": {
        "id": "PDk6yI0H",
        "title": "Existence and multiplicity of solutions for some Dirichlet problems with impulsive effects",
        "abstract": "In this paper, we consider the existence and multiplicity of solutions for some Dirichlet impulsive problems and some existence and multiplicity results are obtained. The solutions are sought by means of Lax–Milgram theorem and some critical theorems.",
        "keywords": [
            "34B37",
            "35B38"
        ],
        "authors": [
            {
                "name": "Jianwen Zhou",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +86 08715033701; fax: +86 08715033701."
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2009
    },
    "QY3JR9eX": {
        "id": "QY3JR9eX",
        "title": "Existence and Global Exponential Stability of Almost Periodic Solution for High-Order BAM Neural Networks with Delays on Time Scales",
        "abstract": "In this paper, by using a fixed point theorem and by constructing a suitable Lyapunov functional, we study the existence and global exponential stability of almost periodic solution for high-order bidirectional associative memory neural networks with delays on time scales. An examples shows the feasibility of our main results.",
        "keywords": [
            "Almost periodic solution",
            "High-order BAM neutral networks",
            "Time scales",
            "Global exponential stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            },
            {
                "name": "Chao Wang",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            },
            {
                "name": "Xia Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2014
    },
    "CxkAvRmt": {
        "id": "CxkAvRmt",
        "title": "Positive periodic solutions of higher-dimensional functional difference equations with a parameter",
        "abstract": "By using Krasnoselskii's fixed point theorem and upper and lower solutions method, we find some sets of positive values λ determining that there exist positive T-periodic solutions to the higher-dimensional functional difference equations of the form x(n+1)=A(n)x(n)+λh(n)fxn−τ(n),n∈Z, where A(n)=diag[a1(n),a2(n),…,am(n)], h(n)=diag[h1(n),h2(n),…,hm(n)], aj,hj:Z→R+, τ:Z→Z are T -periodic, j=1,2,…,m, T⩾1, λ>0, x:Z→Rm, f:R+m→R+m, where R+m={(x1,…,xm)T∈Rm, xj⩾0, j=1,2,…,m}, R+={x∈R,x>0}.",
        "keywords": [
            "Functional difference equation",
            "Positive periodic solution",
            "Fixed point theorem",
            "Upper and lower solutions method"
        ],
        "authors": [
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2004
    },
    "p0Jefcfk": {
        "id": "p0Jefcfk",
        "title": "Existence of positive periodic solutions for difference equations with feedback control",
        "abstract": "We apply the continuation theorem of coincidence degree theory to study the existence of positive periodic solutions for the following difference equations with feedback control: {N(n+1)=N(n)exp[r(n)(1−N(n−m)k(n)−c(n)μ(n))],Δμ(n)=−a(n)μ(n)+b(n)N(n−m), where a:Z→(0,1),c,k,r,b:Z→R+ are all ω-periodic functions and m is a positive integer.",
        "keywords": [
            "Difference equation",
            "Positive periodic solution",
            "Feedback control",
            "Fredholm mapping"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematics Letters",
        "year": 2005
    },
    "oyjxDa7G": {
        "id": "oyjxDa7G",
        "title": "Anti-periodic solutions for Cohen–Grossberg neural networks with bounded and unbounded delays☆",
        "abstract": "In this paper, a class of Cohen–Grossberg neural networks (CGNNs) with bounded and unbounded delays are considered. We establish some sufficient conditions on the existence and exponential stability of anti-periodic solutions for the following Cohen–Grossberg neural networksxi′(t)=-ai(xi(t))bi(xi(t))-∑j=1ncij(t)fj(xj(t))-∑j=1ndij(t)gj(xj(t-τij(t)))-∑j=1neij(t)∫0∞kij(θ)hj(xj(t-θ))dθ-Ii(t),i=1,2,…,n.Moreover, we also present an example to illustrate the feasibility and effectiveness of our results.",
        "keywords": [
            "Cohen–Grossberg neural networks (CGNNs)",
            "Bounded and unbounded delays",
            "Anti-periodic solutions",
            "Exponential stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Li Yang",
                "org": "Department of Mathematics, Yunnan University, Cuihu Beilu 2, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2009
    },
    "rSGnpUH8": {
        "id": "rSGnpUH8",
        "title": "Asymptotic Behavior of a Stochastic Two-Species Competition System with Impulsive Effects",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Pan Wang",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            }
        ],
        "venue": "International Journal of Nonlinear Sciences and Numerical Simulation",
        "year": 2018
    },
    "H33iKF0R": {
        "id": "H33iKF0R",
        "title": "Periodic Solutions for a Class of Singular Hamiltonian Systems on Time Scales",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaofang meng",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "6hGqYjlh": {
        "id": "6hGqYjlh",
        "title": "Stability and existence of periodic solutions for cellular neural networks with state dependent delays on time scales",
        "abstract": "We study delayed cellular neural networks on time scales. Without assuming the boundedness of the activation functions, we establish the exponential stability and existence of periodic solutions. The results in this paper are completely new even in case of the time scale T = R or Z and improve some of the previously known results.",
        "keywords": [],
        "authors": [
            {
                "name": "Yaping Ren",
                "org": "Yunnan Univ Finance & Econ, Sch Math & Stat, Kunming 650221, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2012
    },
    "jsfdr50p": {
        "id": "jsfdr50p",
        "title": "Four positive periodic solutions to two species parasitical system with harvesting terms",
        "abstract": "By using Mawhin's continuation theorem of coincidence degree theory, we establish the existence of four positive periodic solutions for two species parasitical system with harvesting terms. An example is given to illustrate the effectiveness of our results.",
        "keywords": [
            "species parasitical system",
            "coincidence degree theory",
            "parasitical system",
            "positive periodic solution",
            "harvesting term",
            "four positive periodic solutions",
            "continuation theorem",
            "coincidence degree"
        ],
        "authors": [
            {
                "name": "Kaihong Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China and Department of Mathematics, Yuxi Normal University, Yuxi, Yunnan 653100, People's Republic of Ch ..."
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Computers & Mathematics with Applications",
        "year": 2010
    },
    "zlw7YQYM": {
        "id": "zlw7YQYM",
        "title": "Existence and stability of periodic solution for BAM neural networks with distributed delays",
        "abstract": "We use the continuation theorem of coincidence degree theory and Liapunov functions to study the existence and stability of positive periodic solutions for a class of two-layer heteroassociative networks called bidirectional associative memory networksdx\\\"idt=-a\\\"i(t)x\\\"i(t)+@?\\\"j\\\"=\\\"1^mp\\\"j\\\"i(t)f\\\"j(y\\\"j(t-@t\\\"j\\\"i(t,y\\\"j(t))))+I\\\"i(t),i=1,2,...,n,dy\\\"jdt=-b\\\"j(t)y\\\"j(t)+@?\\\"i\\\"=\\\"1^nq\\\"i\\\"j(t)f\\\"i(x\\\"i(t-@s\\\"i\\\"j(t,x\\\"i(t))))+J\\\"j(t),j=1,2,...,manddx\\\"idt=-a\\\"i(t)x\\\"i(t)+@?\\\"j\\\"=\\\"1^mp\\\"j\\\"i(t)f\\\"j@!\\\"0^~h\\\"j\\\"i(s)y\\\"j(t-s)ds+I\\\"i(t),i=1,2,...,n,dy\\\"jdt=-b\\\"j(t)y\\\"j(t)+@?\\\"i\\\"=\\\"1^nq\\\"i\\\"j(t)f\\\"i@!\\\"0^~k\\\"i\\\"j(s)x\\\"i(t-s)ds+J\\\"j(t),j=1,2,...,m.",
        "keywords": [
            "periodic solution",
            "fredholm mapping",
            "state-dependent delay",
            "bidirectional associative memory networks",
            "stability",
            "bidirectional associative memory"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Cuihu Beilu 2, Kunming, Yunnan 650091, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2004
    },
    "f6yuGYKq": {
        "id": "f6yuGYKq",
        "title": "Almost Periodic Synchronization for Quaternion-Valued Neural Networks with Time-Varying Delays.",
        "abstract": "This paper focuses on the global exponential almost periodic synchronization of quaternion-valued neural networks with time-varying delays. By virtue of the exponential dichotomy of linear differential equations, Banach's fixed point theorem, Lyapunov functional method, and differential inequality technique, some sufficient conditions are established for assuring the existence and global exponential synchronization of almost periodic solutions of the delayed quaternion-valued neural networks, which are completely new. Finally, we give one example with simulation to show the applicability and effectiveness of our main results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Xiaofang Meng",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yuan Ye",
                "org": "Yunnan Univ, Grad Sch, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "COMPLEXITY",
        "year": 2018
    },
    "LHCoiVZo": {
        "id": "LHCoiVZo",
        "title": "Permanence and almost periodic solutions for an n-species Lotka–Volterra food chain system on time scales",
        "abstract": "",
        "keywords": [
            "permanence"
        ],
        "authors": [
            {
                "name": "qingshui liao",
                "org": ""
            },
            {
                "name": "bing li",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "Asian-european Journal of Mathematics",
        "year": 2015
    },
    "N579L2ol": {
        "id": "N579L2ol",
        "title": "Almost Automorphic Solutions in Distribution Sense of Quaternion-Valued Stochastic Recurrent Neural Networks with Mixed Time-Varying Delays",
        "abstract": "In this paper, we consider quaternion-valued stochastic recurrent neural networks with mixed time-varying delays by direct method. Base on the Banach fixed point theorem and stochastic analysis techniques, we obtain some sufficient conditions for the existence and global exponential stability of almost automorphic solutions in distribution sense for the neural networks. As special cases of our results, we also obtain the results about the existence and global exponential stability of almost automorphic solutions in distribution sense for complex-valued and real-valued stochastic neural networks. All of these results are new. Finally, we give numerical examples and simulations to illustrate the feasibility of our results.",
        "keywords": [
            "Almost automorphy in distribution",
            " Quaternion",
            " Stochastic recurrent neural networks",
            " Mixed delays"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Xiaofang Meng",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2019
    },
    "z9SO5fhM": {
        "id": "z9SO5fhM",
        "title": "Three periodic solutions for a class of higher-dimensional functional differential equations with impulses",
        "abstract": "By using the well-known Leggett-Williams multiple fixed point theorem for cones, some new criteria are established for the existence of three positive periodic solutions for a class of n-dimensional functional differential equations with impulses of the form {y'(t) = A(t)y(t) + g(t,y(t)), t not equal t(j), j is an element of Z, y(t(j)(+)) = y(t(j)(-)) + I-j (y(t(j))), where A(t) = (a(ij)(t))(nxn) is a nonsingular matrix with continuous real-valued entries.",
        "keywords": [
            "positive periodic solutions",
            "functional differential equations",
            "impulse",
            "Leggett-Williams fixed point theorem"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Changzhao Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Juan Zhang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "ANNALES POLONICI MATHEMATICI",
        "year": 2010
    },
    "DZygkGET": {
        "id": "DZygkGET",
        "title": "Multiple positive periodic solutions for a Gilpin-Ayala competition predator-prey system with harvesting terms",
        "abstract": "By applying Mawhins continuation theorem of coincidence degree theory, we study the existence of multiple positive periodic solutions for a Gilpin-Ayala competition predator-prey system with harvesting terms and obtain some sufficient conditions for the existence of multiple positive periodic solutions for the system under consideration. The result of this paper is completely new. An example is employed to illustrate our result. Copyright © 2012 Yongzhi Liao et al.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongzhi Liao",
                "org": "Panzhihua University(Panzhihua University),Panzhihua,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Xiaoyan Dou",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2012
    },
    "bMRcuCEG": {
        "id": "bMRcuCEG",
        "title": "Impulsive Boundary Value Problems with Riemann–Stieltjes Δ-Integral Conditions and <Emphasis Type=\"Italic\">p</Emphasis>-Laplacian Operator on Timescales",
        "abstract": "In this paper, we study the impulsive boundary value problems with Riemann–Stieltjes Δ-integral conditions and p-Laplacian operator on timescales. Using the Leray–Schauder fixed point theorem and the nonlinear alternative of Leray–Schauder type, we get the existence of at least one positive solution. We also consider the existence of at least three positive solutions using a new fixed point theorem. Finally, we give an example to show the feasibility of our main results.",
        "keywords": [
            "34N05",
            " 34B10",
            " 34B18",
            " Impulsive boundary value problems",
            " p-Laplacian operator",
            " fixed point theorem",
            " timescales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            },
            {
                "name": "Pan Wang",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            }
        ],
        "venue": "Mediterranean Journal of Mathematics",
        "year": 2015
    },
    "aLjQnQJP": {
        "id": "aLjQnQJP",
        "title": "Existence and Global Exponential Stability of Equilibrium Solution to Reaction-Diffusion Recurrent Neural Networks on Time Scales",
        "abstract": "The existence of equilibrium solutions to reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales is proved by the topological degree theory and M-matrix method. Under some sufficient conditions, we obtain the uniqueness and global exponential stability of equilibrium solution to reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales by constructing suitable Lyapunov functional and inequality skills. One example is given to illustrate the effectiveness of our results.",
        "keywords": [
            "reaction diffusion",
            "recurrent neural network"
        ],
        "authors": [
            {
                "name": "Kaihong Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2010
    },
    "Nx873Zb8": {
        "id": "Nx873Zb8",
        "title": "Existence and global exponential stability of equilibrium solution to reaction-diffusion recurrent neural networks on time scales",
        "abstract": "The existence of equilibrium solutions to reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales is proved by the topological degree theory and M-matrix method. Under some sufficient conditions, we obtain the uniqueness and global exponential stability of equilibrium solution to reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales by constructing suitable Lyapunov functional and inequality skills. One example is given to illustrate the effectiveness of our results.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2010
    },
    "Xc5MB9Cu": {
        "id": "Xc5MB9Cu",
        "title": "Sobolev’s spaces on time scales and its applications to a class of second order Hamiltonian systems on time scales",
        "abstract": "In this paper, we study the Sobolev’s spaces on time scales and their properties. As applications, we present a recent approach via variational methods and the critical point theory to obtain the existence of solutions for a class of second order Hamiltonian systems on time scales. By establishing a proper variational setting, three existence results for systems under consideration are obtained. Finally, three examples are presented to illustrate the feasibility and effectiveness of the existence results.",
        "keywords": [
            "Sobolev’s spaces",
            "Time scales",
            "Variational methods",
            "Hamiltonian systems",
            "Critical points"
        ],
        "authors": [
            {
                "name": "Jianwen Zhou",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +86 08715033701; fax: +86 08715033701."
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2010
    },
    "L2yVFyZ2": {
        "id": "L2yVFyZ2",
        "title": "Existence of Positive Periodic Solutions to -Species Nonautonomous Food Chains with Harvesting Terms",
        "abstract": "By using Mawhin's continuation theorem of coincidence degree theory and some skills of inequalities, we establish the existence of at least  Open image in new window  positive periodic solutions for  Open image in new window -species nonautonomous Lotka-Volterra type food chains with harvesting terms. An example is given to illustrate the effectiveness of our results.",
        "keywords": [
            "food chain"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "kaihong zhao",
                "org": "yunnan university"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2010
    },
    "6tRaxUry": {
        "id": "6tRaxUry",
        "title": "Multiple positive periodic solutions of nonlinear functional differential system with feedback control",
        "abstract": "In this paper, we employ Avery–Henderson fixed point theorem to study the existence of positive periodic solutions to the following nonlinear nonautonomous functional differential system with feedback control: dxdt=−r(t)x(t)+F(t,xt,u(t−δ(t))),dudt=−h(t)u(t)+g(t)x(t−σ(t)). We show that the system above has at least two positive periodic solutions under certain growth condition imposed on F.",
        "keywords": [
            "Positive periodic solution",
            "Functional differential equation",
            "Feedback control",
            "Fixed-point theorem"
        ],
        "authors": [
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            },
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2003
    },
    "0PWuAEds": {
        "id": "0PWuAEds",
        "title": "Stepanov-Like Asymptotical Almost Periodic Functions and an Application",
        "abstract": "In this paper, we first study some basic properties of Stepanov-like asymptotical almost periodic functions including the completeness of the space of Stepanov-like asymptotical almost periodic functions. Then, as an application, based on these and the contraction mapping principle, we obtain sufficient conditions for the existence and uniqueness of Stepanov-like asymptotical almost periodic solutions for a class of semilinear delay differential equations.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yaolu Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Jianglian Xiang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF FUNCTION SPACES",
        "year": 2018
    },
    "mBQ4PJqG": {
        "id": "mBQ4PJqG",
        "title": "Existence and Global Exponential Stability of Almost Automorphic Solution for Clifford-Valued High-Order Hopfield Neural Networks with Leakage Delays",
        "abstract": "In this paper, we study the existence and global exponential stability of almost automorphic solutions for Clifford-valued high-order Hopfield neural networks by direct method. That is to say, we do not decompose the systems under consideration into real-valued systems, but we directly study Clifford-valued systems. Our methods and results are new. Finally, an example is given to illustrate our main results.",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Li",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650500, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "COMPLEXITY",
        "year": 2019
    },
    "lM0tqZeo": {
        "id": "lM0tqZeo",
        "title": "Permanence of a discrete n-species cooperation system with time-varying delays and feedback controls",
        "abstract": "In this paper, a discrete n-species cooperation system with time-varying delays and feedback controls is considered. By using the techniques of [Y.H. Fan, L.L. Wang, Permanence for a discrete model with feedback control and delay, Discrete Dyn. Nat. Soc. (2008) Article ID 945109], sufficient conditions are obtained for the permanence of the system, which improve a result given in [F.D. Chen, Permanence of a discrete N-species cooperation system with time delays and feedback controls, Appl. Math. Comput. 186 (2007) 23-29].",
        "keywords": [
            "sufficient condition",
            "feedback control",
            "permanence",
            "discrete",
            "article id",
            "l.l. wang",
            "discrete model",
            "discrete n-species cooperation system",
            "cooperation system",
            "discrete dyn",
            "time delay",
            "time-varying delay"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Mathematical and Computer Modelling",
        "year": 2011
    },
    "Atdqauej": {
        "id": "Atdqauej",
        "title": "Persistence of a discrete mutualism model",
        "abstract": "The persistence of a discrete mutualism model is studied.When assuming that the model is periodic,the existence and the global stability of a periodic solution are established.",
        "keywords": [
            "periodic solution",
            "mutualism model",
            "global stability",
            "persistence"
        ],
        "authors": [
            {
                "name": "LIU Xin-guo",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            },
            {
                "name": "LIU Xing-gui",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            }
        ],
        "venue": "Journal of Yunnan University(Natural Sciences Edition)",
        "year": 2007
    },
    "71PUIsOw": {
        "id": "71PUIsOw",
        "title": "Existence and Multiplicity of Solutions to a Boundary Value Problem for Impulsive Differential Equations.",
        "abstract": "We investigate the existence and multiplicity of solutions to a boundary value problem for impulsive differential equations. By using critical point theory, some criteria are obtained to guarantee that the impulsive problem has at least one solution, at least two solutions, and infinitely many solutions. Some examples are given to illustrate the effectiveness of our results.",
        "keywords": [],
        "authors": [
            {
                "name": "Chunyan He",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongzhi Liao",
                "org": "Panzhihua Univ, Sch Math & Comp Sci, Panzhihua 617000, Sichuan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF APPLIED MATHEMATICS",
        "year": 2013
    },
    "crStLnMu": {
        "id": "crStLnMu",
        "title": "Existence and Global Exponential Stability of Equilibrium Point for a Class of Fuzzy BAM Neural Networks with Time-Varying Delays",
        "abstract": "In this paper,a class of fuzzy BAM neural networks with time-varying delays are investigated.By using topological degree theory and differential inequality, we obtain some sufficient conditions for the existence,uniqueness and global exponential stability of equilibrium point for a class of fuzzy BAM neural networks with time-varying delays.Moreover,we also present an illustrative example to show the effectiveness of obtained results.",
        "keywords": [
            "BAM neural networks",
            "Equilibrium point",
            "Differential inequality",
            "Topological degree theory",
            "Exponential stability"
        ],
        "authors": [
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University Kunming,Kunming Yunnan  China"
            },
            {
                "name": "YANG Li",
                "org": "Department of Mathematics,Yunnan University Kunming,Kunming Yunnan  China"
            },
            {
                "name": "WU Wan-qin",
                "org": "Department of Mathematics,Yunnan University Kunming,Kunming Yunnan  China"
            }
        ],
        "venue": "Journal of Biomathematics",
        "year": 2010
    },
    "GQzK2UWe": {
        "id": "GQzK2UWe",
        "title": "Multiple positive solutions for first-order impulsive integral boundary value problems on time scales",
        "abstract": "In this paper, we first present a class of first-order nonlinear impulsive integral boundary value problems on time scales. Then, using the well-known Guo-Krasnoselskii fixed point theorem and Legget-Williams fixed point theorem, some criteria for the existence of at least one, two, and three positive solutions are established for the problem under consideration, respectively. Finally, examples are presented to illustrate the main results.",
        "keywords": [
            "integral boundary value problem",
            " fixed point",
            " multiple solutions",
            " time scale"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "jiangye shu",
                "org": "yunnan university"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2011
    },
    "uKAZIWFj": {
        "id": "uKAZIWFj",
        "title": "Existence and globally exponential stability of almost periodic solution for Cohen–Grossberg BAM neural networks with variable coefficients",
        "abstract": "In this paper, a class of Cohen–Grossberg BAM neural networks with variable coefficients are studied. Some sufficient conditions are established for the existence and uniqueness of the almost periodic solution. These results have important leading significance in designs and applications of Cohen–Grossberg BAM neural networks. Finally, an example is presented to illustrate the feasibility and effectiveness of the results.",
        "keywords": [
            "Globally exponential stability",
            "Delayed cellular neural networks",
            "Almost periodic solution"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Xuanlong Fan",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "P60xuaLd": {
        "id": "P60xuaLd",
        "title": "Existence and global exponential stability of equilibrium for discrete-time fuzzy BAM neural networks with variable delays and impulses",
        "abstract": "In this paper, we study a class of discrete-time fuzzy BAM neural networks with variable delays and impulses. Based on M-matrix theory and analytic methods, some sufficient conditions are established for the existence and global exponential stability of a unique equilibrium. Moreover, the exponential convergence rate index is estimated. A numerical example is given to show the effectiveness of the obtained results. In particular, the simulation figures establish that fuzzy systems do have more advantages than non-fuzzy systems.",
        "keywords": [
            "sufficient condition",
            "exponential convergence rate index",
            "discrete-time fuzzy bam neural",
            "non-fuzzy system",
            "global exponential stability",
            "fuzzy system",
            "analytic method",
            "m-matrix theory",
            "variable delay",
            "simulation figure",
            "numerical example",
            "equilibrium point"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Chao Wang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Fuzzy Sets and Systems",
        "year": 2013
    },
    "mZ3wT1vo": {
        "id": "mZ3wT1vo",
        "title": "Existence and Stability of Antiperiodic Solution for a Class of Generalized Neural Networks with Impulses and Arbitrary Delays on Time Scales",
        "abstract": "By using coincidence degree theory and Lyapunov functions, we study the existence and global exponential stability of antiperiodic solutions for a class of generalized neural networks with impulses and arbitrary delays on time scales. Some completely new sufficient conditions are established. Finally, an example is given to illustrate our results. These results are of great significance in designs and applications of globally stable anti-periodic Cohen-Grossberg neural networks with delays and impulses.",
        "keywords": [
            "Lyapunov Function",
            " Discontinuity Point",
            " Generalize Exponential Function",
            " Hopfield Neural Network",
            " Global Exponential Stability"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "erliang xu",
                "org": "yunnan university"
            },
            {
                "name": "tianwei zhang",
                "org": "yunnan university"
            }
        ],
        "venue": "Journal of Inequalities and Applications",
        "year": 2010
    },
    "an9sC8us": {
        "id": "an9sC8us",
        "title": "Anti-periodic solutions for neutral type FCNNs with time-varying delays and D D operator on time scales",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Li",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            }
        ],
        "venue": "The Journal of Nonlinear Sciences and Applications",
        "year": 2017
    },
    "fYPmsA1n": {
        "id": "fYPmsA1n",
        "title": "Three Positive Periodic Solutions to Nonlinear Neutral Functional Differential Equations with Parameters on Variable Time Scales.",
        "abstract": "Using two successive reductions: B-equivalence of the system on a variable time scale to a system on a time scale and a reduction to an impulsive differential equation and by Leggett-Williams fixed point theorem, we investigate the existence of three positive periodic solutions to the nonlinear neutral functional differential equation on variable time scales with a transition condition between two consecutive parts of the scale (d/dt)(x(t) + (c(t)x(t - alpha)) = a (t)g(x(t))x(t) - Sigma(n)(j=1)lambda(j)f(j)(t, x(t - v(j)(t))), (t, x) is an element of T-0(x),Delta t vertical bar((t,x)is an element of S2i) = Pi(1)(i)(t,x) - t, Delta x vertical bar((t,x)is an element of S2i) = Pi(2)(i)(t,x) - x, where Pi(1)(i)(t,x) = t(2i+1) + tau(2i+1)(Pi(2)(i)(t,x) and Pi(2)(i)(t,x) = B(i)x + J(i)(x) + (x, i = 1, 2, ... lambda(j) (j = 1, 2, ... , n) are parameters, T-0(x) is a variable time scale with (omega, p)-property, c(t), a(t), v(j)(t), and f(j)(t,x)(j = 1, 2, ... , n) are omega-periodic functions of t, Bi+p = B-i, J(i+p) (x) = J(i)(x) uniformly with respect to i is an element of Z.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Yunnan 650091, Kunming, Peoples R China"
            },
            {
                "name": "Chao Wang",
                "org": "Yunnan Univ, Dept Math, Yunnan 650091, Kunming, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF APPLIED MATHEMATICS",
        "year": 2012
    },
    "8lLsfrqt": {
        "id": "8lLsfrqt",
        "title": "Weighted pseudo-almost periodic solutions and global exponential synchronization for delayed QVCNNs",
        "abstract": "In this paper, we study the existence of weighted pseudo-almost periodic solutions and the global exponential synchronization of delayed quaternion-valued cellular neural networks (QVCNNs). Firstly, we use the Banach fixed point theorem to establish the existence of weighted pseudo-almost periodic solutions for this class of QVCNNs. Then, under the condition that the drive system has a unique weighted pseudo-almost periodic solution, by designing a state-feedback controller and constructing suitable Lyapunov functions, we see that the drive–response structure of delayed QVCNNs with weighted pseudo-almost periodic coefficients achieve global exponential synchronization. Finally, a numerical example is given to illustrate the feasibility of our results.",
        "keywords": [
            "34K14",
            " 34D06",
            " 92B20",
            " Weighted pseudo-almost periodic solution",
            " Synchronization",
            " Quaternion",
            " Cellular neural networks"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Gui Lü",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Xiaofang Meng",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            }
        ],
        "venue": "Journal of Inequalities and Applications",
        "year": 2019
    },
    "DNzJR7Kc": {
        "id": "DNzJR7Kc",
        "title": "Almost periodic solutions of shunting inhibitory cellular neural networks on time scales",
        "abstract": "In this paper shunting inhibitory cellular neural networks (SICNNs) with time-varying and continuously distributed delays are considered on time scale T. Without assuming the global Lipschitz conditions of activation functions, some new sufficient conditions for the existence and asymptotic stability of the almost periodic solutions are established on time scales. Two numerical examples are given to illustrate our feasible results. © 2011 Elsevier B.V.",
        "keywords": [
            "Almost periodic solutions",
            "Shunting inhibitory cellular neural networks",
            "Asymptotic stability",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Chao Wang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2012
    },
    "b68Szwvw": {
        "id": "b68Szwvw",
        "title": "EXISTENCE AND ATTRACTIVITY OF PERIODIC SOLUTIONS TO COHEN-GROSSBERG NEURAL NETWORK WITH DISTRIBUTED DELAYS",
        "abstract": "We study the existence and exponential attractivity of periodic solutions to Cohen-Grossberg neural network with distributed delays. Our re- sults are obtained by applying the continuation theorem of coincidence degree theory and a general Halanay inequality.",
        "keywords": [
            "coincidence degree theory",
            "periodic solution",
            "halanay inequality. c 2005 texas state university",
            "continuation theorem",
            "san marcos.",
            "distributed delays",
            ". cohen-grossberg neural network"
        ],
        "authors": [
            {
                "name": "YONGKUN LI",
                "org": ""
            },
            {
                "name": "LIFEI ZHU",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "lsVkr8h0": {
        "id": "lsVkr8h0",
        "title": "Anti-periodic Solutions for Rayleigh Equations with Delay",
        "abstract": "In this paper,we study the existence of anti-periodic solutions for a kind of Rayleigh equations with delay by using the fixed theorem of the Leray-Schauder degree theory.We obtain sufficient conditions for the existence of anti-periodic solutions.Finally,two examples are presented to illustrate the feasibility and effectiveness of the sufficient conditions.",
        "keywords": [
            "Rayleigh equation",
            "Leray-Schauder degree",
            "anti-periodic solutions",
            "delay"
        ],
        "authors": [
            {
                "name": "ZHOU Jian-wen",
                "org": "Department of Mathematics,Yunnan University,Kunming "
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming "
            },
            {
                "name": "WANG Yan-ning",
                "org": "Department of Mathematics,Yunnan University,Kunming "
            }
        ],
        "venue": "Chinese Journal of Engineering Mathematics",
        "year": 2011
    },
    "hO469ATa": {
        "id": "hO469ATa",
        "title": "Permanence and almost periodic sequence solution for a discrete delay logistic equation with feedback control",
        "abstract": "In this paper, we consider a discrete delay logistic equation with feedback control. By applying the theory of difference inequality and constructing a suitable Lyapunov functional, sufficient conditions which guarantee the permanence and existence of a unique globally attractive positive almost periodic sequence solution of the system are obtained. The result of this paper is completely new. An example is employed to illustrate our main result.",
        "keywords": [
            "Discrete",
            "Delay logistic equation",
            "Permanence",
            "Almost periodic solution"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +86 08715033701; fax: +86 08715147713."
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2011
    },
    "p7TcAjA7": {
        "id": "p7TcAjA7",
        "title": "$$S^{p}$$Sp-Almost Periodic Solutions of Clifford-Valued Fuzzy Cellular Neural Networks with Time-Varying Delays",
        "abstract": "In this paper, we consider Clifford-valued fuzzy cellular neural networks with time-varying delays. In order to avoid the inconvenience caused by the non-commutativity of the multiplication of Clifford numbers, we first decompose the considered n-dimensional Clifford-valued systems into $$2^{m}n$$-dimensional real-valued systems. Then by using the Banach fixed point theorem and a proof by contradiction, we establish sufficient conditions ensuring the existence, the uniqueness and the global exponential stability of $$S^{p}$$-almost periodic solutions for the considered neural networks. Finally, we give an example to illustrate the effectiveness of the obtained results. Our results are new even when the considered neural networks degenerates to real-valued, complex-valued and quaternion-valued neural networks.",
        "keywords": [
            "Clifford-valued fuzzy cellular neural networks",
            " \n\n\n\n-almost periodic solution",
            " Global exponential stability"
        ],
        "authors": [
            {
                "name": "Shiping Shen",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2020
    },
    "puQh2L2j": {
        "id": "puQh2L2j",
        "title": "Three Positive Periodic Solutions for a Class of Higher-Dimensional Functional Differential Equations with Impulses on Time Scales",
        "abstract": "Abstract By using a multiple fixed point theorem (Avery-Peterson fixed point theorem) for cones, some criteria are established for the existence of three positive periodic solutions for a class of higher-dimensional functional differential equations with impulses on time scales of the following form: , , , where is a nonsingular matrix with continuous real-valued functions as its elements. Finally, an example is presented to illustrate the feasibility and effectiveness of the results.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "yunnan university"
            },
            {
                "name": "Meng Hu",
                "org": "yunnan university"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2009
    },
    "9bkGSMmm": {
        "id": "9bkGSMmm",
        "title": "Existence and stability of antiperiodic solution for a class of generalized neural networks with impulses and arbitrary delays on time scales",
        "abstract": "By using coincidence degree theory and Lyapunov functions, we study the existence and global exponential stability of antiperiodic solutions for a class of generalized neural networks with impulses and arbitrary delays on time scales. Some completely new sufficient conditions are established. Finally, an example is given to illustrate our results. These results are of great significance in designs and applications of globally stable anti-periodic Cohen-Grossberg neural networks with delays and impulses. © 2010 Yongkun Li et al.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Tianwei Zhang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Erliang Xu",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Journal of Inequalities and Applications",
        "year": 2010
    },
    "msXkz4xL": {
        "id": "msXkz4xL",
        "title": "Positive Periodic Solutions of Neutral Functional Differential Equations with State Dependent Delays on Time Scales",
        "abstract": "By using a fixed point theorem on strict-set-contraction,some sufficient conditionsare obtained for the existence of positive periodic solutions for a periodic neutral functionaldifferential equation on time scales of the formx~Δ(t)=x(t)[r(t)-a(t)x(t)-(?)a_j(t)x(t -τ_j(t,x(t)))-(?)c_j(t)x~Δ(t -σ_j(t,x(t))),where r,a,a_j,c_j∈C(T,R~+)(j=1,2,…,n) areω-periodic functions,andτ_j,σ_j∈C(T×R,T)(j=1,2,…,n) areω-periodic functions with respect to their first arguments,respectively.",
        "keywords": [
            "Positive periodic solution",
            "Strict-set-contraction",
            "Neutral functional differential equation",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Li Yongkun",
                "org": "Department of Mathematics,Yunnan University,Kunming "
            },
            {
                "name": "Zhang Hongtao",
                "org": "Department of Mathematics,Yunnan University,Kunming "
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2010
    },
    "BPezjoPy": {
        "id": "BPezjoPy",
        "title": "Three positive periodic solutions to nonlinear neutral functional differential equations with impulses and parameters on time scales",
        "abstract": "In this paper, using the Leggett-Williams fixed point theorem, we investigate the existence of three positive periodic solutions to the nonlinear neutral functional differential equations with impulses and parameters on time scales {(x(t)+c(t)x(t-r\"1))^@D=a(t)g(x(t))x(t)-@?i=1n@l\"if\"i(t,x(t-@t\"i(t))),tt\"j,t@?T,j=1,2,...,q,x(tj-)-x(tj+)=I\"j(x(t\"j)),t=t\"j,j=1,2,...,q, where @l\"i, i=1,2,...,n are parameters, T is an @w-periodic time scale, a@?C(T,R^+),c@?C(T,[0,1)) and both of them are @w-periodic functions, @t\"i@?C(T,R),i=1,2,...,n are@w-periodic functions, f\"i@?C(TxR^+,R^+),i=1,2,...,n are nondecreasing with respect to their second arguments and @w-periodic with respect to their first arguments, respectively; g@?C(R^+,R^+) and there exist two positive constants l,L such that 00,I\"j@?C(R,R^+)(j=1,2,...,q) and is bounded, r\"1 is a constant.",
        "keywords": [
            "nonlinear neutral functional differential",
            "w-periodic time scale",
            "positive periodic solution",
            "w-periodic function",
            "neutral functional differential equation",
            "leggett-williams fixed point theorem",
            "positive constants l",
            "time scale",
            "fixed point theorem"
        ],
        "authors": [
            {
                "name": "Chao Wang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China and School of Statistics and Mathematics, Yunnan University of Finance and Economics, Kunming, Yunn ..."
            },
            {
                "name": "Yu Fei",
                "org": "School of Statistics and Mathematics, Yunnan University of Finance and Economics, Kunming, Yunnan 650221, People's Republic of China"
            }
        ],
        "venue": "Mathematical and Computer Modelling",
        "year": 2010
    },
    "rcDk2Tlw": {
        "id": "rcDk2Tlw",
        "title": "Existence and global exponential stability of anti-periodic solutions for quaternion-valued cellular neural networks with time-varying delays",
        "abstract": "In this paper, we are concerned with a class of quaternion-valued cellular neural networks with time-varying transmission delays and leakage delays. By applying a continuation theorem of coincidence degree theory and the Wirtinger inequality as well as constructing a suitable Lyapunov functional, sufficient conditions are derived to ensure the existence and global exponential stability of anti-periodic solutions via direct approaches. Our results are completely new. Finally, numerical examples are also provided to show the effectiveness of our results.",
        "keywords": [
            "Quaternion-valued neural network",
            " Anti-periodic solution",
            " Coincidence degree",
            " Wirtinger inequality",
            " Lyapunov functional"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            },
            {
                "name": "Jianglian Xiang",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2020
    },
    "MQWRmNRC": {
        "id": "MQWRmNRC",
        "title": "Multiple positive almost periodic solutions to an impulsive non-autonomous Lotka-Volterra predator-prey system with harvesting terms",
        "abstract": "In this paper, by using Mawhin's continuation theorem of coincidence degree theory, we study an impulsive non-autonomous Lotka-Volterra predator-prey system with harvesting terms and obtain some sufficient conditions for the existence of multiple positive almost periodic solutions for the system under consideration. Our results of this paper are completely new and our method used in this paper can be used to study the existence of multiple positive almost periodic solutions to other types of population systems. © 2013 Elsevier B.V.",
        "keywords": [
            "Lotka–Volterra network",
            "Predator–prey system",
            "Almost periodic solution",
            "Impulse",
            "Coincidence degree"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yuan Ye",
                "org": "School of Graduate, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2013
    },
    "sImvMk5Z": {
        "id": "sImvMk5Z",
        "title": "Positive periodic solutions of discrete Lotka–Volterra competition systems with state dependent and distributed delays",
        "abstract": "By using a fixed point theorem of strict-set-contraction, the existence of positive periodic solutions is established for the following discrete Lotka–Volterra competition systems with state dependent and distributed delays.Δxi(n)=xi(n)ai(n)-∑j=1paij(n)xj(fij(n,x1(n),x2(n),…,xp(n)))-∑j=1pbij(n)∑θ=-Tij0Hij(θ)xj(n+θ),i=1,2,…,p.",
        "keywords": [
            "Positive periodic solution",
            "Lotka–Volterra system",
            "Functional difference equation",
            "Strict-set-contraction"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "my3rGqz9": {
        "id": "my3rGqz9",
        "title": "Stability of Reaction-Diffusion Recurrent Neural Networks with Distributed Delays and Neumann Boundary Conditions on Time Scales.",
        "abstract": "The existence of equilibrium solutions to reaction-diffusion recurrent neural networks with distributed delays and Neumann boundary conditions on time scales is proved by the topological degree theory and M-matrix method. Under some sufficient conditions, we obtain the uniqueness and global exponential stability of equilibrium solution to reaction-diffusion recurrent neural networks with distributed delays and Neumann boundary conditions on time scales by constructing suitable Lyapunov functional and inequality skills. Two examples are given to illustrate the effectiveness of our results. © Springer Science+Business Media, LLC. 2012.",
        "keywords": [
            "Reaction-diffusion recurrent neural networks",
            "Global exponential stability",
            "Topological degree theory",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Yuan Ye",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2012
    },
    "SQ2URINo": {
        "id": "SQ2URINo",
        "title": "ANTI-PERIODIC BOUNDARY VALUE PROBLEMS FOR HIGHER-DIMENSIONAL IMPULSIVE FUNCTIONAL DIFFERENTIAL EQUATIONS ON TIME SCALES",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lili zhao",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "s85DrIAX": {
        "id": "s85DrIAX",
        "title": "Permanence and almost periodic solutions for a single-species system with impulsive effects on time scales",
        "abstract": "In this paper, we first propose a single-species system with impulsive effects on time scales and by establishing some new comparison theorems of impulsive dynamic equations on time scales, we obtain sufficient conditions to guarantee the permanence of the system. Then we prove a Massera type theorem for impulsive dynamic equations on time scales and based on this theorem, we establish a criterion for the existence and uniformly asymptotic stability of a unique positive almost periodic solution of the system. Finally, we give an example to show the feasibility of our main results. Our example also shows that the continuous time system and its corresponding discrete time system have the same dynamics. Our results of this paper are completely new. (C) 2016 All rights reserved.",
        "keywords": [
            "Impulsive single-species model",
            "comparison theorem",
            "permanence",
            "almost periodic solution",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Pan Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Bing Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF NONLINEAR SCIENCES AND APPLICATIONS",
        "year": 2016
    },
    "gilOgfJb": {
        "id": "gilOgfJb",
        "title": "Existence and Exponential Stability of Periodic Solution of High-Order Hopfield Neural Network with Delays on Time Scales",
        "abstract": "On time scales, by using the continuation theorem of coincidence degree theory and constructing some suitable Lyapunov functions, the periodicity and the exponential stability are investigated for a class of delayed high-order Hopfield neural networks (HHNNs), which are new and complement of previously known results. Finally, an example is given to show the effectiveness of the proposed method and results. Copyright (c) 2009 Yongkun Li et al.",
        "keywords": [
            "exponential stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Lili Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Ping Liu",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2009
    },
    "bUKuVcw7": {
        "id": "bUKuVcw7",
        "title": "Extremal Solutions of Periodic Boundary Value Problems for Order Impulsive First Integro-Differential Equations of Mixed Type",
        "abstract": "This paper considers the existence of minimal and maximal solutions of periodic boundary value problems for the first order impulsive integro-differential equations of mixed type by establishing a comparison result and using the monotone iterative technique.",
        "keywords": [
            "Impulsive integro-differential equation",
            "Comparison theorem",
            "Extremal solution",
            "Periodic boundary value problem",
            "Monotone iterative technique"
        ],
        "authors": [
            {
                "name": "Zhang Hongtao",
                "org": "Department of Mathematics,Yunnan University,Kunming Yunnan "
            },
            {
                "name": "Li Yongkun",
                "org": "Department of Mathematics,Yunnan University,Kunming Yunnan "
            }
        ],
        "venue": "Journal of Mathematical Study",
        "year": 2008
    },
    "kw2tlXC2": {
        "id": "kw2tlXC2",
        "title": "On the existence of solutions for impulsive duffing dynamic equations on time scales with dirichlet boundary conditions",
        "abstract": "By using critical point theory, some new sufficient conditions for the existence of solutions of impulsive Duffing dynamic equations on time scales with Dirichlet boundary conditions are obtained. Some examples are also given to illustrate our results. © 2010 Yongkun Li and Tianwei Zhang.",
        "keywords": [
            "dirichlet boundary condition"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2010
    },
    "T8Ly5vVv": {
        "id": "T8Ly5vVv",
        "title": "On the existence and stability of a unique almost periodic sequence solution in discrete predator–prey models with time delays",
        "abstract": "In this paper, we consider an almost periodic discrete predator–prey models with time delays:x(k+1)=x(k)expa(k)-b(k)x(k)-p(k,x(k),y(k),x(k-μ),y(k-ν))y(k)x(k),y(k+1)=y(k)expc(k)-d(k)y(k)x(k-μ),where μ, ν are nonnegative integers. Sufficient conditions for the permanence of the system and the existence of a unique uniformly asymptotically stable positive almost periodic sequence solution are obtained by the theory of difference inequality and the work of [S.N. Zhang, G. Zheng, Almost periodic solutions of delay difference systems, Appl. Math. Comput. 131 (2002) 497–516]. The result of this paper is completely new. Some suitable examples are employed to illustrate the feasibility of the main results.",
        "keywords": [
            "Delay",
            "Discrete",
            "Predator–prey model",
            "Almost periodic solution"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yuan Ye",
                "org": "Graduate School of Yunnan University, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2011
    },
    "y8tRO6c5": {
        "id": "y8tRO6c5",
        "title": "Anti-periodic solutions for a class of Cohen-Grossberg neural networks with time-varying delays on time scales",
        "abstract": "In this article, a class of Cohen-Grossberg neutral networks (CGNNs) with time-varying delays on time scales is considered. We establish some sufficient conditions on the existence and exponential stability of anti-periodic solutions for CGNNs  [image omitted] where t ∈ ,  is a periodic time scale, i = 1, 2,..., n.",
        "keywords": [
            "sufficient condition",
            "cohen-grossberg neutral network",
            "exponential stability",
            "cohen-grossberg neural network",
            "anti-periodic solution",
            "periodic time scale",
            "time scale",
            "time-varying delay",
            "neutral network",
            "asymptotic stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, P.R. China"
            },
            {
                "name": "Li Yang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, P.R. China"
            },
            {
                "name": "Wanqin Wu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, P.R. China"
            }
        ],
        "venue": "Int. J. Systems Science",
        "year": 2010
    },
    "MQqIsECT": {
        "id": "MQqIsECT",
        "title": "Existence of solutions for a class of damped vibration problems on time scales",
        "abstract": "We present a recent approach via variational methods and critical point theory to obtain the existence of solutions for a class of damped vibration problems on time scale T, uΔ2 (t) + w(t)uΔ (σ(t)) = ∇F(σ(t), u (σ(t))), Δ-a.e. t ∈ [0, T] T κ , u(0) - u(T) = 0, uΔ(0) - uΔ(T) = 0, where uΔ(t) denotes the delta (or Hilger) derivative of u at t, uΔ2 (t) = (uΔ) Δ (t), σ is the forward jump operator, T is a positive constant, w ∈ R+([0, T]T, ℝ), ew(T, 0) = 1, and F: [0, T]T × ℝN → ℝ. By establishing a proper variational setting, three existence results are obtained. Finally, three examples are presented to illustrate the feasibility and effectiveness of our results. Copyright © 2010 Yongkun Li and Jianwen Zhou.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Jianwen Zhou",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2010
    },
    "Emd64VwD": {
        "id": "Emd64VwD",
        "title": "On the asymptotically cubic fractional Schrödinger–Poisson system",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Wenbo Wang",
                "org": "School of Mathematics and Statistics, Yunnan University, Kunming, People's Republic of China"
            },
            {
                "name": "Yuanyang Yu",
                "org": "Academy of Mathematics and Systems Sciences, Institute of Mathematics, CAS, Beijing, People's Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Mathematics and Statistics, Yunnan University, Kunming, People's Republic of China"
            }
        ],
        "venue": "Applicable Analysis",
        "year": 2019
    },
    "JL0fm6BD": {
        "id": "JL0fm6BD",
        "title": "Positive periodic solutions of nonlinear functional difference equations depending on a parameter",
        "abstract": "In this paper, we use the upper and lower solutions method to show that there existsa @l^*, such that the nonlinear functional difference equation of the form @g(n + 1) = a(n)@g(n) + @lh(n)@?(@g(n - @t(n))), n @e Z, has at least one positive T-periodic solutions for @l @e (0, @l^* and does not have any positive T-periodic solutions for @l @l^*, where a(n), h(n), and @t(n) are T-periodic functions.",
        "keywords": [
            "lower solutions method",
            "positive periodic solution",
            "t-periodic function",
            "nonlinear functional difference equation",
            "upper and lower solutions",
            "positive t-periodic solution",
            "difference equation"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Author to whom all correspondence should be addressed."
            },
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, P.R. China"
            },
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, P.R. China"
            }
        ],
        "venue": "Computers & Mathematics with Applications",
        "year": 2004
    },
    "rbZXkvcz": {
        "id": "rbZXkvcz",
        "title": "Square-mean almost periodic solutions for impulsive stochastic shunting inhibitory cellular neural networks with delays",
        "abstract": "In this paper, we consider a class of impulsive stochastic shunting inhibitory cellular neural networks with delays. By using the fixed points principle and Gronwall-Bellman¿s inequality technique, we obtain the existence and exponential stability of square-mean almost periodic solutions for this class of networks. Finally, we give an example to illustrate the feasibility of our results.",
        "keywords": [
            "Exponential stability",
            "Square-mean almost periodic solutions",
            "Impulsive stochastic neural networks",
            "Delays"
        ],
        "authors": [
            {
                "name": "Pan Wang",
                "org": "Department of Mathematics, Yunnan University"
            },
            {
                "name": "Bing Li",
                "org": "Department of Mathematics, Yunnan University"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2015
    },
    "zoYses5Y": {
        "id": "zoYses5Y",
        "title": "On μ-Pseudo Almost Periodic Solutions for Clifford-Valued Neutral Type Neural Networks With Delays in the Leakage Term.",
        "abstract": "We propose a class of Clifford-valued neutral type neural networks with delays in the leakage term. Using a direct method, that is, without decomposing the Clifford-valued system under consideration into a real-valued system, we obtain sufficient conditions for the existence and global exponential stability of μ-pseudo almost periodic solutions of the Clifford-valued neural network under consideration. Finally, we give a numerical example to show the feasibility of our results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Nina Huo",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Neural Networks Learn. Syst.",
        "year": 2021
    },
    "HW702xQL": {
        "id": "HW702xQL",
        "title": "Almost Automorphic Solutions for Quaternion-Valued Hopfield Neural Networks with Mixed Time-Varying Delays and Leakage Delays",
        "abstract": "This paper considers a class of quaternion-valued Hopfield neural networks with mixed time-varying delays and leakage delays. By utilizing the exponential dichotomy of linear differential equations, Banach’s fixed point theorem and differential inequality techniques, the authors obtain some sufficient conditions to ensure the existence and global exponential stability of almost automorphic solutions for this class of quaternion-valued neural networks. The results are completely new. Finally, the authors give an example to illustrate the feasibility of the results.",
        "keywords": [
            "Almost automorphic solutions",
            " exponential stability",
            " Hopfield neural networks",
            " leakage delays",
            " quaternion-valued functions"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,China"
            },
            {
                "name": "Xiaofang Meng",
                "org": "Department of Mathematics,Yunnan University,Kunming,China"
            }
        ],
        "venue": "Journal of Systems Science and Complexity",
        "year": 2020
    },
    "XP7ZB7Wy": {
        "id": "XP7ZB7Wy",
        "title": "Ground states for planar axially Schrödinger–Newton system with an exponential critical growth",
        "abstract": "In this paper, we study the following planar Schrödinger–Newton system: $$ \\left \\{ \\textstyle\\begin{array}{l} -\\Delta u+ V(x)u+\\lambda\\phi u= f(x,u)\\quad \\textrm{in } \\mathbb{R}^{2},\\\\ \\Delta\\phi=u^{2}\\quad\\textrm{in } \\mathbb{R}^{2}, \\end{array}\\displaystyle \\right . $$ where V, f are axially symmetric about x, V is positive, and f is super-linear at zero and exponential critical at infinity. Using a weaker condition $$ \\biggl[\\frac{f(x,u)}{u^{3}}-\\frac{f(x,tu)}{(tu)^{3}} \\biggr]\\operatorname {sign}(1-t)+ \\theta V(x)\\frac{ \\vert 1-t^{2} \\vert }{(tu)^{2}}\\geq0,\\quad \\forall x\\in \\mathbb{R}^{2}, t>0, u\\neq0 $$ with $\\theta\\in[0,1)$ instead of the Nehari type monotonic condition on $\\frac{f(x,u)}{|u|^{3}}$, we obtain a ground state solution of the above problem via variational methods.",
        "keywords": [
            "35J50",
            " 35J20",
            " 35J10",
            " Schrödinger–Newton system",
            " Axial symmetry",
            " The exponential critical growth",
            " Ground states"
        ],
        "authors": [
            {
                "name": "Wenbo Wang",
                "org": "School of Mathematics and Statistics, Yunnan University, Kunming, P.R. China"
            },
            {
                "name": "Quanqing Li",
                "org": "Department of Mathematics, Honghe University, Mengzi, P.R. China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Mathematics and Statistics, Yunnan University, Kunming, P.R. China"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2020
    },
    "Xsd6mYzd": {
        "id": "Xsd6mYzd",
        "title": "Almost periodic solutions for neutral delay Hopfield neural networks with time-varying delays in the leakage term on time scales",
        "abstract": "In this paper, a class of neutral delay Hopfield neural networks with time-varying delays in the leakage term on time scales is considered. By utilizing the exponential dichotomy of linear dynamic equations on time scales, Banach’s fixed point theorem and the theory of calculus on time scales, some sufficient conditions are obtained for the existence and exponential stability of almost periodic solutions for this class of neural networks. Finally, a numerical example illustrates the feasibility of our results and also shows that the continuous-time neural network and the discrete-time analogue have the same dynamical behaviors. The results of this paper are completely new and complementary to the previously known results even when the time scale \nT\n=\nR\n or \nZ\nOpen image in new window.",
        "keywords": [
            "almost periodic solutions",
            " Hopfield neural networks",
            " neutral delay",
            " leakage term",
            " time scales"
        ],
        "authors": [
            {
                "name": "ling li",
                "org": "yunnan university"
            },
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "li yang",
                "org": "yunnan university"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2014
    },
    "SpEePMAn": {
        "id": "SpEePMAn",
        "title": "Almost periodic solutions of quaternion-valued neutral type high-order Hopfield neural networks with state-dependent delays and leakage delays",
        "abstract": "In this paper, we consider the existence and global exponential stability of almost periodic solutions for a class of quaternion-valued neutral type neural networks with state-dependent delays and leakage delays by a direct approach. That is, without decomposing the considered quaternion-valued systems into real-valued systems, by using the contraction mapping fixed point theorem, we obtain the existence of almost periodic solutions of the considered networks with state-dependent delays and leakage delays, and by the counter-evidence method, we obtain the global exponential stability of almost periodic solutions of the considered networks with discrete delays and leakage delays. When the time delays in the considered systems are proportional time delays, our existence results are still true. At the same time, when the considered systems degenerate into real-valued or complex-valued systems, our results are still new.",
        "keywords": [
            "Almost periodic solution",
            " Global exponential stability",
            " Quaternion-valued high-order Hopfield neural network",
            " State-dependent delay"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan, People’s Republic of China"
            },
            {
                "name": "Jianglian Xiang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan, People’s Republic of China"
            },
            {
                "name": "Bing Li",
                "org": "School of Mathematics and Computer Science, Yunnan Minzu University, Kunming, Yunnan, People’s Republic of China"
            }
        ],
        "venue": "Applied Intelligence",
        "year": 2020
    },
    "Cy57DP9M": {
        "id": "Cy57DP9M",
        "title": "Anti-periodic Solutions for Quaternion-Valued High-Order Hopfield Neural Networks with Time-Varying Delays",
        "abstract": "In this paper, quaternion-valued high-order Hopfield neural networks (QVHHNNs) with time-varying delays are considered. Theoretically, a QVHHNN can be separated into four real-valued systems, forming an equivalent real-valued system. By using a novel continuation theorem of coincidence degree theory and constructing an appropriate Lyapunov function, some sufficient conditions are derived to guarantee the existence and global exponential stability of anti-periodic solutions for QVHHNN, which are new and complement previously known results.",
        "keywords": [
            "High-order Hopfield neural networks",
            "Quaternion",
            "Coincidence degree",
            "Anti-periodic solution",
            "Time-vary delay"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            },
            {
                "name": "Jiali Qin",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            },
            {
                "name": "Bing Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,People’s Republic of China"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2018
    },
    "57yNJFH7": {
        "id": "57yNJFH7",
        "title": "Anti-periodic solutions for quaternion-valued inertial neural networks with time-varying delays.",
        "abstract": "In this paper, we consider a class of quaternion-valued inertial neural networks with time-varying delays. First, by applying a continuation theorem of coincidence degree theory, we establish the existence of anti-periodic solutions of the considered neural networks. Second, by choosing a proper variable substitution, we transform the neural networks into a system of first order differential equations, and by constructing a suitable Lyapunov function, we derive a set of sufficient conditions ensuring the global exponential stability of the system. Finally, we give two examples to illustrate the effectiveness of our results.",
        "keywords": [
            "Quaternion-valued inertial neural networks",
            "anti-periodic solutions",
            "coincidence degree",
            "exponential stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Chun Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF INTELLIGENT & FUZZY SYSTEMS",
        "year": 2019
    },
    "CsxRUFkp": {
        "id": "CsxRUFkp",
        "title": "Impulsive Boundary Value Problems with Riemann–Stieltjes Δ-Integral Conditions and p-Laplacian Operator on Timescales",
        "abstract": "In this paper, we study the impulsive boundary value problems with Riemann-Stieltjes Delta-integral conditions and p-Laplacian operator on timescales. Using the Leray-Schauder fixed point theorem and the nonlinear alternative of Leray-Schauder type, we get the existence of at least one positive solution. We also consider the existence of at least three positive solutions using a new fixed point theorem. Finally, we give an example to show the feasibility of our main results.",
        "keywords": [
            "Impulsive boundary value problems",
            "p-Laplacian operator",
            "fixed point theorem",
            "timescales"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "pan wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MEDITERRANEAN JOURNAL OF MATHEMATICS",
        "year": 2016
    },
    "eQHGacuW": {
        "id": "eQHGacuW",
        "title": "The existence of nonzero almost periodic solution for Cohen-Grossberg neural networks with continuously distributed delays and impulses",
        "abstract": "By using Banach fixed point theorem, some criteria are established for the existence of nonzero almost periodic solution for Cohen-Grossberg neural networks with continuously distributed delays and impulses. The results in this paper are completely new and complement and improve some of the previously known results. An example is employed to illustrate our feasible results.",
        "keywords": [
            "periodic solution",
            "cohen-grossberg neural network",
            "feasible result",
            "banach fixed point theorem"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Zhiwei Xing",
                "org": "Department of Mathematics, Xi'an Jiaotong University, Xi'an, Shanxi 710049, People's Republic of China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2010
    },
    "qu8g27IC": {
        "id": "qu8g27IC",
        "title": "Positive periodic solutions for an integrodifferential model of mutualism",
        "abstract": "Sufficient conditions are obtained for the existence of positive periodic solutions of the following integrodifferential model of mutualism: dN(1)(t)/dt = r(1)(t)N-1(t) [K-1(t) + alpha (1)(t) integral (infinity)(0) J(2)(s)N-2(t - s)ds/1 + integral (infinity)(0) J(2)N(2)(t - s)ds - N-1(t - sigma (1)(t))], dN(2)a(t)/dt = r(2)r(t)N-2(t) [K-2(t) + alpha (2)(t) integral (infinity)(0) J(1)(s)N-1(t - s)ds/ 1 + integral (infinity)(0) J(1)(s)N-1(t - s)ds - N-2(t - sigma (2)(t))], where tau (i), K-i, alpha (i), sigma (i), i = 1,2 are positive continuous omega -periodic functions, alpha (i) > K-i, i = 1,2, J(i) is an element of C([0, infinity], [0, infinity]), and integral (infinity)(0) J(i)(s) ds = 1, i = 1, 2. (C) 2001 Elsevier Science Ltd. All rights reserved.",
        "keywords": [
            "mutualism model",
            "positive periodic solution",
            "integrodifferential equation",
            "Fredholm mapping"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, P.R. China"
            },
            {
                "name": "Guitong Xu",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, P.R. China"
            }
        ],
        "venue": "APPLIED MATHEMATICS LETTERS",
        "year": 2001
    },
    "3dq0LYq6": {
        "id": "3dq0LYq6",
        "title": "An application of variational approach to a class of damped vibration problems with impulsive effects on time scales",
        "abstract": "In this paper, we present a new approach via variational methods and critical point theory to obtain the existence and multiplicity of solutions to a class of damped vibration problems with impulsive effects on time scales. By establishing a proper variational set, two existence results and two multiplicity results are obtained. Finally, one example is presented to illustrate the feasibility and effectiveness of our results.",
        "keywords": [
            "damped vibration problems",
            " impulse",
            " time scales"
        ],
        "authors": [
            {
                "name": "jianwen zhou",
                "org": "yunnan university"
            },
            {
                "name": "yanning wang",
                "org": "yunnan university"
            },
            {
                "name": "yongkun li",
                "org": "yunnan university"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2015
    },
    "XOtFf5pT": {
        "id": "XOtFf5pT",
        "title": "Variational Approach to a Class of Second Order Hamiltonian Systems on Time Scales",
        "abstract": "In this paper, we present a recent approach via variational methods and critical point theory to obtain the existence of solutions for the second order Hamiltonian system on time scale $\\mathbb{T}$ $$\\left\\{\\begin{array}{l@{\\quad}l}u^{\\Delta^{2}}(t)+A(\\sigma(t))u(\\sigma(t))+\\nabla F(\\sigma(t),u(\\sigma(t)))=0,& \\hbox{\\ $\\Delta$-a.e. $t\\in [0,T]_{_{\\mathbb{T}}}^{\\kappa}$,} \\\\u(0)-u(T)=0,\\qquad u^{\\Delta}(0)-u^{\\Delta}(T)=0,& \\hbox{}\\end{array}\\right.$$ where u Δ(t) denotes the delta (or Hilger) derivative of u at t, $u^{\\Delta^{2}}(t)=(u^{\\Delta})^{\\Delta}(t)$ , 驴 is the forward jump operator, T is a positive constant, A(t)=[d ij (t)] is a symmetric N脳N matrix-valued function defined on $[0,T]_{\\mathbb{T}}$ with $d_{ij}\\in L^{\\infty}([0,T]_{\\mathbb{T}},\\mathbb{R})$ for all i,j=1,2,驴,N, and $F:[0,T]_{\\mathbb{T}}\\times \\mathbb{R}^{N}\\rightarrow\\mathbb{R}$ . By establishing a proper variational setting, two existence results and two multiplicity results are obtained. Finally, three examples are presented to illustrate the feasibility and effectiveness of our results.",
        "keywords": [
            "Variational approach",
            "Hamiltonian systems",
            "Time scales",
            "Critical points",
            "34N05",
            "37J45",
            "34C25"
        ],
        "authors": [
            {
                "name": "Jianwen Zhou",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China 650091"
            }
        ],
        "venue": "Acta Applicandae Mathematicae: an international survey journal on applying mathematics and mathematical applications",
        "year": 2012
    },
    "E9kztGyB": {
        "id": "E9kztGyB",
        "title": "Existence and Exponential Stability of Anti-periodic Solutions of High-order Hopfield Neural Networks with Delays on Time Scales",
        "abstract": "On time scales, a class of delayed high-order Hopfield neural networks are considered. We establish some sufficient conditions\n on the existence and exponential stability of anti-periodic solutions for the following Hopfield neural networks with time-varying\n and distributed delays\n \n \n \n \n $$\\begin{array}{l} x_i^{\\Delta}(t)\\,=\\,-c_i(t)x_i(t)+\\sum\\limits^n_{j=1}a_{ij}(t)f_j\\left(x_j(t-\\gamma_{ij}(t))\\right)\\\\ \\,\\quad\\,\\quad\\,\\quad\\,\\,+\\,\\sum\\limits^n_{j=1} \\sum\\limits_{l=1}^{n}b_{ijl}(t)\\int\\limits_0^{\\infty}k_{ij}(\\theta)g_j(x_j(t-\\theta))\\Delta \\theta \\int\\limits_0^{\\infty}k_{il}(\\theta)g_l(x_l(t-\\theta))\\Delta \\theta\\\\ \\,\\quad\\,\\quad\\,\\quad\\,\\,+\\,\\quad I_i(t),\\quad i=1,2,\\ldots,n\\end{array}$$\n \n \n \n on time scales. Finally, an example is given to show the effectiveness of the proposed method and results.",
        "keywords": [
            "timescales ·time-varyingdelays ·distributeddelays ·anti-periodicsolution · high-order hopfield neural networks",
            "exponential stability"
        ],
        "authors": [
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, 650091 Yunnan, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, 650091 Yunnan, People’s Republic of China"
            }
        ],
        "venue": "Differential Equations and Dynamical Systems",
        "year": 2011
    },
    "f8Ullwyx": {
        "id": "f8Ullwyx",
        "title": "Robust Stability Analysis of Fuzzy Neural Network with Delays",
        "abstract": "We investigate local robust stability of fuzzy neural networks (FNNs) with time-varying and S-type distributed delays. We derive some sufficient conditions for local robust stability of equilibrium points and estimate attracting domains of equilibrium points except unstable equilibrium points. Our results not only show local robust stability of equilibrium points but also allow much broader application for fuzzy neural network with or without delays. An example is given to illustrate the effectiveness of our results. Copyright (C) 2009 K. Zhao and Y. Li.",
        "keywords": [
            "fuzzy neural network"
        ],
        "authors": [
            {
                "name": "Kaihong Zhao",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL PROBLEMS IN ENGINEERING",
        "year": 2009
    },
    "xX6gW422": {
        "id": "xX6gW422",
        "title": "Anti-periodic solutions for a class of 2nth-order nonlinear differential equations with delays",
        "abstract": "By applying a fixed point theorem of coincidence degree theory, some criteria are established for the existence of anti-periodic solutions to a class of 2nth-order nonlinear differential equations with delays in the form of u (2n)(t) + ∑ k = 1 2n 1 (-1) k 1a k(u (k - 1)(t))u (k)(t)g(t,u(t - τ(t))) = e(t). We extend some recent results to obtain a completely new result. Finally, some examples are given to illustrate our result. © 2011 World Scientific Publishing Company.",
        "keywords": [
            "2nth-order equation",
            "anti-periodic solution",
            "coincidence degree"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "tianwei zhang",
                "org": ""
            }
        ],
        "venue": "Asian-European Journal of Mathematics",
        "year": 2011
    },
    "DrmWuhjK": {
        "id": "DrmWuhjK",
        "title": "Multiple positive solutions for second-order p-Laplacian dynamic equations with integral boundary conditions",
        "abstract": "We are concerned with the following second-order p-Laplacian dynamic equations on time scales (phi(p)(x(Delta)(t)))(del) + lambda f(t, x(t), x(Delta)(t)) = 0, t is an element of (0, T)(T), with integral boundary conditions x(Delta)(0) = 0, alpha x(T) - beta x(0) = integral(T)(0) g(s)x(s)del s. By using Legget-Williams fixed point theorem, some criteria for the existence of at least three positive solutions are established. An example is presented to illustrate the main result.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "BOUNDARY VALUE PROBLEMS",
        "year": 2011
    },
    "FT4F96pF": {
        "id": "FT4F96pF",
        "title": "Existence and global exponential stability of anti-periodic solutions for delayed quaternion-valued cellular neural networks with impulsive effects",
        "abstract": "In this paper, we consider a class of delayed quaternion-valued cellular neural networks (DQVCNNs) with impulsive effects. By using a novel continuation theorem of coincidence degree theory, the existence of anti-periodic solutions for DQVCNNs is obtained with or without assuming that the activation functions are bounded. Furthermore, by constructing a suitable Lyapunov function, some sufficient conditions are derived to guarantee the global exponential stability of anti-periodic solutions for DQVCNNs. Our results are new and complementary to the known results even when DQVCNNs degenerate into real-valued or complex-valued neural networks. Finally, an example is given to illustrate the effectiveness of the obtained results.",
        "keywords": [
            "anti-periodic solution",
            "neural networks",
            "quaternion",
            "stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of MathematicsYunnan University Kunming China"
            },
            {
                "name": "Jiali Qin",
                "org": "Department of MathematicsYunnan University Kunming China"
            },
            {
                "name": "Bing Li",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            }
        ],
        "venue": "MATHEMATICAL METHODS IN THE APPLIED SCIENCES",
        "year": 2019
    },
    "r9dF9h4Y": {
        "id": "r9dF9h4Y",
        "title": "Periodic solutions for stochastic shunting inhibitory cellular neural networks with distributed delays",
        "abstract": "In this paper, by using an integral inequality, we establish some sufficient conditions ensuring the existence and p-exponential stability of periodic solutions for a class of stochastic shunting inhibitory cellular neural networks (SICNNs) with distributed delays. Moreover, we present an example to illustrate the feasibility of our theoretical results.",
        "keywords": [
            "stochastic SICNNs",
            " distributed delays",
            " periodic solution",
            " p-exponential stability"
        ],
        "authors": [
            {
                "name": "li yang",
                "org": "yunnan university"
            },
            {
                "name": "yongkun li",
                "org": "yunnan university"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2014
    },
    "vUkg0LDm": {
        "id": "vUkg0LDm",
        "title": "Existence and Global Exponential Stability of Pseudo Almost Periodic Solutions for Neutral Type Quaternion-Valued Neural Networks with Delays in the Leakage Term on Time Scales.",
        "abstract": "We propose a class of neutral type quaternion-valued neural networks with delays in the leakage termon time scales that can unify the discrete-time and the continuous-time neural networks. In order to avoid the difficulty brought by the noncommutativity of quaternion multiplication, we first decompose the quaternion-valued system into four real-valued systems. Then, by applying the exponential dichotomic theory of linear dynamic equations on time scales, Banach's fixed point theorem, the theory of calculus on time scales, and inequality techniques, we obtain some sufficient conditions on the existence and global exponential stability of pseudo almost periodic solutions for this class of neural networks. Our results are completely new even for both the case of the neural networks governed by differential equations and the case of the neural networks governed by difference equations and show that, under a simple condition, the continuous-time quaternion-valued network and its corresponding discrete-time quaternion-valued network have the same dynamical behavior for the pseudo almost periodicity. Finally, a numerical example is given to illustrate the feasibility of our results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Xiaofang Meng",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "COMPLEXITY",
        "year": 2017
    },
    "URjAoMaz": {
        "id": "URjAoMaz",
        "title": "Oscillatory criteria of general nonlinear hyperbolic equations with continuous deviating arguments",
        "abstract": "In this paper, a class of hyperbolic partial functional differential equations boundary value problem is concerned, and sufficient conditions for the oscillation of solutions of the equation under the consideration with two kinds of boundary conditions are obtained.",
        "keywords": [
            "Oscillation",
            "Hyperbolic equation",
            "Continuous deviating arguments"
        ],
        "authors": [
            {
                "name": "Wenxiang Liu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China"
            },
            {
                "name": "Maochang Qin",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2003
    },
    "OyThn6Rg": {
        "id": "OyThn6Rg",
        "title": "Existence of solutions for a class of second-order Hamiltonian systems with impulsive effects",
        "abstract": "In this paper, a class of second-order Hamiltonian systems with impulsive effects are considered. We establish some sufficient conditions for the existence of solutions for the second-order Hamiltonian systems with impulsive effects {ü(t)=∇F(t,u(t)),a.e. t∈[0,T];u(0)−u(T)=u̇(0)−u̇(T)=0,Δu̇i(tj)=u̇i(tj+)−u̇i(tj−)=Iij(ui(tj)),i=1,2,…,N,j=1,2,…,p, where t0=0<t1<t2<⋯<tp<tp+1=T, u(t)=(u1(t),u2(t),…,uN(t))∈RN, Iij:R→R(i=1,2,…,N,j=1,2,…,p) are continuous and F:[0,T]×RN→R. The solutions are sought by means of some critical point theorems. Finally, two examples are presented to illustrate the feasibility and effectiveness of our results.",
        "keywords": [
            "Hamiltonian systems",
            "Impulse",
            "Critical points"
        ],
        "authors": [
            {
                "name": "Jianwen Zhou",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +86 08715033701; fax: +8608715033701."
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2010
    },
    "xPdzGv6E": {
        "id": "xPdzGv6E",
        "title": "Existence and Stability of Pseudo Almost Periodic Solution for Neutral Type High-Order Hopfield Neural Networks with Delays in Leakage Terms on Time Scales",
        "abstract": "Using the exponential dichotomy of linear dynamic equations on time scales, a fixed point theorem and the theory of calculus on time scales, we obtain some sufficient conditions for the existence and global exponential stability of pseudo almost periodic solutions for a class of neutral type high-order Hopfield neural networks with delays in leakage terms on time scales. Our results show that the continuous-time neural network and its discrete-time analogue have the same dynamical behaviors. Finally, we give a numerical example and simulation to illustrate the feasibility of our results. Results of this paper are completely new even if the time scale $$\\\\mathbb {T}=\\\\mathbb {R}$$T=R or $$\\\\mathbb {Z}$$Z.",
        "keywords": [
            "Pseudo almost periodic solution",
            "High-order Hopfield neural networks",
            "Exponential stability",
            "Time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "yunnan university"
            },
            {
                "name": "Li Yang",
                "org": "yunnan university of finance and economics"
            },
            {
                "name": "Bing Li",
                "org": "yunnan university"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 2015
    },
    "CBjFxEWf": {
        "id": "CBjFxEWf",
        "title": "Existence of solutions for a four-point boundary value problem of a nonlinear fractional differential equation",
        "abstract": "",
        "keywords": [
            "schauder fixed point theorem",
            "green s function"
        ],
        "authors": [
            {
                "name": "xiaoyan dou",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "ping liu",
                "org": ""
            }
        ],
        "venue": "Opuscula Mathematica",
        "year": 2011
    },
    "lo2FNqJK": {
        "id": "lo2FNqJK",
        "title": "Almost automorphic funtions on time scales and almost automorphic solutions to shunting inhibitory cellular neural networks on time scales",
        "abstract": "In this paper, we first propose a new definition of almost automorphic functions on almost periodic time scales and study some of their basic properties. Then we prove a result ensuring the existence of an almost automorphic solution for both the linear nonhomogeneous dynamic equation on time scales and its associated homogeneous equation, assuming that the latter admits an exponential dichotomy. Finally, as an application of our results, we establish the existence and global exponential stability of almost automorphic solutions to a class of shunting inhibitory cellular neural networks with time-varying delays on time scales. Our results about the shunting inhibitory cellular neural networks with time-varying delays on time scales are new both for the case of differential equations (the time scale T = R) and difference equations (the time scale T = Z). (C) 2015 All rights reserved.",
        "keywords": [
            "Time scales",
            "Almost automorphic functions",
            "Dynamic equations",
            "Exponential dichotomy"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "bing li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "xiaofang meng",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF NONLINEAR SCIENCES AND APPLICATIONS",
        "year": 2015
    },
    "Fegvjyvs": {
        "id": "Fegvjyvs",
        "title": "Existence of Positive Periodic Solutions for <Emphasis Type=\"Italic\">n</Emphasis>-Dimensional Functional Differential Equations with Impulse Effects",
        "abstract": "",
        "keywords": [
            "Positive periodic solutions",
            " Functional differential equations",
            " Impulse",
            " Fixed point"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming, Yunnan,People’s Republic of China"
            },
            {
                "name": "Changzhao Li",
                "org": "Department of Mathematics,Yunnan University,Kunming, Yunnan,People’s Republic of China"
            }
        ],
        "venue": "Differential Equations and Dynamical Systems",
        "year": 2011
    },
    "1ax4BxpX": {
        "id": "1ax4BxpX",
        "title": "Multiple positive solutions of nonlinear third-order boundary value problems with integral boundary conditions on time scales",
        "abstract": "In this paper, we consider a class of nonlinear third-order boundary value problems with integral boundary conditions on time scales. By applying a generalization of the Leggett-Williams fixed point theorem, we establish the existence of at least three positive solutions. The discussed problem involves both an increasing and positive homomorphism, which generalizes the p-Laplacian operator. As an application, we give an example to illustrate our results.",
        "keywords": [
            "time scales",
            " fixed point theorem",
            " integral boundary conditions",
            " multiple positive solutions",
            " cone"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "lingyan wang",
                "org": "yunnan university"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2015
    },
    "isuIuoLY": {
        "id": "isuIuoLY",
        "title": "Research Article Bifurcation Analysis for a Two-Dimensional Discrete-Time Hopfield Neural Network with Delays",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yaping Ren",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "eK0SCw7a": {
        "id": "eK0SCw7a",
        "title": "Existence and Exponential Stability of Anti-Periodic Solutions for Inertial Quaternion-Valued High-Order Hopfield Neural Networks With State-Dependent Delays.",
        "abstract": "This paper deals with a class of inertial quaternion-valued high-order Hopfield neural networks with state-dependent delays. Without decomposing the considered neural networks into real-valued systems, based on a continuation theorem of coincidence degree theory and the Wirtinger inequality, the existence of anti-periodic solutions of the networks is established. By constructing a suitable Lyapunov function, the global exponential stability of anti-periodic solutions of the networks is obtained. Finally, a numerical example is given to show the feasibility of our results.",
        "keywords": [
            "Anti-periodic solution",
            "global exponential stability",
            "inertial high-order Hopfield neural networks",
            "quaternion",
            "state-dependent delay"
        ],
        "authors": [
            {
                "name": "Nina Huo",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Bing Li",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650504, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "IEEE ACCESS",
        "year": 2019
    },
    "D4ADnlWq": {
        "id": "D4ADnlWq",
        "title": "Multiple Positive Periodic Solutions of a Competitor-Competitor-Mutualist Lotka-Volterra System with Harvesting Terms",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "erliang xu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "eij5SBIl": {
        "id": "eij5SBIl",
        "title": "Positive periodic solutions of a periodic neutral delay logistic equation with impulses",
        "abstract": "By using a fixed point theorem of strict-set-contraction, some criteria are established for the existence of positive periodic solutions for a periodic neutral functional differential equation with impulses of the form {dx(t)dt=x(t)[a(t)-@?i=1mb\"i(t)x(t-@t\"i(t))-@?j=1nc\"j(t)x^'(t-@s\"j(t))],x(t\"k^+)-x(t\"k)=-I\"k(x(t\"k)),k=1,2,....",
        "keywords": [
            "periodic neutral delay logistic",
            "positive periodic solution",
            "impulse",
            "periodic neutral functional differential",
            "strict-set-contraction",
            "neutral functional differential equation",
            "fixed point theorem",
            "logistic equation"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Computers & Mathematics with Applications",
        "year": 2008
    },
    "TqDoK15p": {
        "id": "TqDoK15p",
        "title": "Almost Periodic Functions on the Quantum Time Scale and Applications",
        "abstract": "In this paper, we first propose two types of concepts of almost periodic functions on the quantum time scale. Secondly, we study some basic properties of almost periodic functions on the quantum time scale. Thirdly, based on these, we study the existence and uniqueness of almost periodic solutions of dynamic equations on the quantum time scale by Lyapunov method. Then, we give an equivalent definition of almost periodic functions on the quantum time scale. Finally, as an application, we propose a class of high-order Hopfield neural networks on the quantum time scale and establish the existence and global exponential stability of almost periodic solutions of this class of neural networks.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "DISCRETE DYNAMICS IN NATURE AND SOCIETY",
        "year": 2019
    },
    "IUJMAsL9": {
        "id": "IUJMAsL9",
        "title": "Existence and multiplicity of solutions for some second-order systems on time scales with impulsive effects",
        "abstract": "Abstract In this paper, we present a recent approach via variational methods and critical point theory to obtain the existence of solutions for the nonautonomous second-order system on time scales with impulsive effects where , ( ), , is a symmetric matrix-valued function defined on with for all , ( , ) are continuous and . Finally, two examples are presented to illustrate the feasibility and effectiveness of our results. MSC: 34B37, 34N05.",
        "keywords": [
            "nonautonomous second-order systems",
            "time scales",
            "impulse",
            "variational approach"
        ],
        "authors": [
            {
                "name": "Jianwen Zhou",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan, 650091, People’s Republic of China"
            },
            {
                "name": "Yanning Wang",
                "org": "Oxbridge College, Kunming University of Science and Technology, Kunming, Yunnan, 650106, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan, 650091, People’s Republic of China"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2012
    },
    "9gtJH8lK": {
        "id": "9gtJH8lK",
        "title": "New Results on Exponential Stability of Competitive Neural Networks with Multi-Proportional Delays: New Results on Exponential Stability of Competitive Neural Networks",
        "abstract": "In this paper, we are concerned with a class of competitive neural networks with multi-proportional delays. By applying the Banach fixed point theorem and constructing suitable Lyapunov functions, we obtain new sufficient conditions for the global exponential stability to this class of neural networks, which are easily verifiable. Finally, two examples are given to illustrate the effectiveness of the obtained results.",
        "keywords": [
            "Competitive neural networks",
            "proportional delays",
            "exponential stability"
        ],
        "authors": [
            {
                "name": "Jiali Qin",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "ASIAN JOURNAL OF CONTROL",
        "year": 2020
    },
    "BpKuZTSY": {
        "id": "BpKuZTSY",
        "title": "Existence and Global Exponential Stability of Almost Periodic Solutions for a Class of Delay Duffing Equations on Time Scales",
        "abstract": "Based on the exponential dichotomy of linear dynamic equations on time scales, we obtain some sufficient conditions for the existence and global exponential stability of almost periodic solutions for a class of Duffing equations with time-varying delays on time scales. We also present numerical examples to show the feasibility of obtained results. The results of this paper are completely new even when the time scale T = R or Z and are complementary to the previously known results.",
        "keywords": [],
        "authors": [
            {
                "name": "li yang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2014
    },
    "jxrQ7xtq": {
        "id": "jxrQ7xtq",
        "title": "Almost Periodic Solutions to Dynamic Equations on Time Scales and Applications.",
        "abstract": "We first introduce the concept of admitting an exponential dichotomy to a class of linear dynamic equations on time scales and study the existence and uniqueness of almost periodic solution and its expression form to this class of linear dynamic equations on time scales. Then, as an application, using these concepts and results, we establish sufficient conditions for the existence and exponential stability of almost periodic solution to a class of Hopfield neural networks with delays. Finally, two examples and numerical simulations given to illustrate our results are plausible and meaningful.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Chao Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF APPLIED MATHEMATICS",
        "year": 2012
    },
    "KQFNYjkG": {
        "id": "KQFNYjkG",
        "title": "-Almost Periodic Functions and an Application to a Lasota-Wazewska Model on Time Scales",
        "abstract": "We first give the definition and some properties of C-n-almost periodic functions on time scales. Then, as an application, we are concerned with a class of Lasota-Wazewska models on time scales. By means of the fixed point theory and differential inequality techniques on time scales, we obtain some sufficient conditions ensuring the existence and global exponential stability of C-1-almost periodic solutions for the considered model. Our results are essentially new when T = R or T = Z. Finally, we present a numerical example to show the feasibility of obtained results.",
        "keywords": [],
        "authors": [
            {
                "name": "li yang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "wanqin wu",
                "org": "Yunnan Nationalities Univ, Sch Math & Comp Sci, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF APPLIED MATHEMATICS",
        "year": 2014
    },
    "ddbncGyC": {
        "id": "ddbncGyC",
        "title": "Exponential stability of generalized Cohen-Grossberg neural networks with distributed delays",
        "abstract": "The dynamics is studied for generalized Cohen-Grossberg neural networks with distributed delays. By means of the nonlinear measure approach and constructing a Lyapunov function,a sufficient condition is obtained for the existence anduniqueness of an equilibrium point of this equations,which of the equilibrium point is global exponential stability. This condition is independent of the delays. Finally,an illustrative examples is given to show the effectiveness of the presented criteria.",
        "keywords": [
            "Lyapunov functional",
            "global expo-nential stability",
            "distributed",
            "generalized Cohen-Grossberg neuralnetworks"
        ],
        "authors": [
            {
                "name": "HUA Yu-chun",
                "org": " Department of Mathematics,Yunnan University,Kunming ,China"
            },
            {
                "name": "LI Yong-kun",
                "org": " Department of Mathematics,Yunnan University,Kunming ,China"
            }
        ],
        "venue": "Journal of Yunnan University(Natural Sciences Edition)",
        "year": 2010
    },
    "XV1hycUr": {
        "id": "XV1hycUr",
        "title": "Stability and Hopf bifurcation analysis on a delayed Leslie-Gower predator-prey system incorporating a prey refuge",
        "abstract": "In this paper, a modified Leslie-Gower predator-prey system with time delays is investigated, where the time delays are regarded as bifurcation parameters. By analyzing the corresponding characteristic equation, the local stability of a positive equilibrium is considered. Moreover, we show that Hopf bifurcations occur when time delay crosses some critical values. By deriving the equation describing the flow on the center manifold, we give the formula for determining the direction of the Hopf bifurcation and the stability of bifurcating periodic solutions. In addition, we also try on the global existence of periodic solutions by using the global Hopf bifurcation result of Wu [J. Wu, Symmetric functional differential equations and neural networks with memory, Trans. Amer. Math. Soc. 350 (1998) 4799-4838.] for functional differential equations. Numerical simulations are carried out to illustrate the theoretical results and they show that the time delays in the system under consideration can destroy the stability of the system.",
        "keywords": [
            "hopf bifurcation",
            "hopf bifurcation analysis",
            "global hopf bifurcation result",
            "modified leslie-gower predator-prey system",
            "functional differential equation",
            "j. wu",
            "local stability",
            "corresponding characteristic equation",
            "bifurcation parameter",
            "prey refuge",
            "periodic solution",
            "time delay",
            "delayed leslie-gower predator-prey system",
            "stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Changzhao Li",
                "org": "Department of Applied Mathematics, Kunming University of Science and Technology, Kunming 650093, Yunnan, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2013
    },
    "Ea7hWl4S": {
        "id": "Ea7hWl4S",
        "title": "Existence and global exponential stability of anti-periodic solution for Clifford-valued inertial Cohen-Grossberg neural networks with delays.",
        "abstract": "In this paper, we are concerned with a class of Clifford-valued inertial Cohen-Grossberg neural networks with time-varying delays. Based on the coincidence degree theory and the Wirtinger inequality, we first obtain sufficient conditions ensuring the existence of anti-periodic solutions for this class of networks. Then, by constructing a suitable Lyapunov functional, we establish the global exponential stability of the anti-periodic solutions. Our results are completely new even if the considered neural networks degenerate into real-valued, complex-valued or quaternion-valued. Finally, we present a numerical example to show the effectiveness of our results",
        "keywords": [
            "Inertial Cohen–Grossberg neural networks",
            "Clifford algebra",
            "Anti-periodic solutions",
            "Global exponential stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Jianglian Xiang",
                "org": "Department of MathematicsYunnan University KunmingYunnan650091People’s Republic of China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2019
    },
    "ywcRw6Gc": {
        "id": "ywcRw6Gc",
        "title": "Stability and existence of periodic solutions to delayed Cohen-Grossberg BAM neural networks with impulses on time scales",
        "abstract": "In this paper, by using the continuation theorem of coincidence degree theory and constructing some suitable Lyapunov functions, we study the stability and existence of periodic solutions to delayed Cohen-Grossberg BAM neural networks with impulses on time scales.",
        "keywords": [
            "suitable lyapunov function",
            "periodic solution",
            "coincidence degree theory",
            "continuation theorem",
            "delayed cohen-grossberg bam neural",
            "time scale",
            "lyapunov function"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Xuerong Chen",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Lu Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2009
    },
    "s1MmzDOl": {
        "id": "s1MmzDOl",
        "title": "Periodic Solutions for a Class of Fuzzy BAM Neural Networks with Distributed Delays and Variable Coefficients",
        "abstract": "",
        "keywords": [
            "BAM neural networks",
            "Brouwer fixed point theorem",
            "distributed delays",
            "exponential stability",
            "periodic solutions"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Li Yang",
                "org": ""
            },
            {
                "name": "Wanqin Wu",
                "org": ""
            }
        ],
        "venue": "I. J. Bifurcation and Chaos",
        "year": 2010
    },
    "XKZ4ApaH": {
        "id": "XKZ4ApaH",
        "title": "Weighted pseudo almost periodic solutions for Clifford-valued neutral-type neural networks with leakage delays on time scales",
        "abstract": "In this paper, we consider a class of Clifford-valued neutral-type neural networks with leakage delays on time scales. We do not decompose the networks under consideration into real-valued systems, but we directly study the Clifford-valued networks. We first establish the existence of weighted pseudo almost periodic solutions of this class of neural networks by the theory of calculus on time scales and the Banach fixed point theorem. Then, we study the global exponential stability of weighted pseudo almost periodic solutions of this class of neural networks by using inequality techniques and the proof by contradiction. Finally, we give an example to illustrate the feasibility of the obtained results.",
        "keywords": [
            "Weighted pseudo almost periodic solutions",
            " Clifford-valued neutral-type cellular neural networks",
            " Global exponential stability",
            " Time scales"
        ],
        "authors": [
            {
                "name": "Shiping Shen",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2020
    },
    "IgcPMf27": {
        "id": "IgcPMf27",
        "title": "Weighted pseudo almost automorphic functions with applications to abstract dynamic equations on time scales",
        "abstract": "We propose a concept of weighted pseudo almost automorphic functions on almost periodic time scales and study some important properties of weighted pseudo almost automorphic functions on almost periodic time scales. As applications, we obtain the conditions for the existence of weighted pseudo almost automorphic mild solutions to a class of semilinear dynamic equations on almost periodic time scales.",
        "keywords": [
            "weighted pseudo almost automorphic functions",
            "abstract differential equations",
            "mild solutions",
            "almost periodic time scales"
        ],
        "authors": [
            {
                "name": "Chao Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "ANNALES POLONICI MATHEMATICI",
        "year": 2013
    },
    "V8iWiRy6": {
        "id": "V8iWiRy6",
        "title": "Extremal Solutions of Periodic Boundary Value Problems for First-Order Impulsive Integrodifferential Equations of Mixed-Type on Time Scales",
        "abstract": "We consider the existence of minimal and maximal solutions of periodic boundary value problems for first-order impulsive integrodifferential equations of mixed-type on time scales by establishing a comparison result and using the monotone iterative technique.",
        "keywords": [
            "first order"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming,China"
            },
            {
                "name": "Hongtao Zhang",
                "org": "Department of Mathematics,Yunnan University,Kunming,China"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2007
    },
    "yFh3Wj0t": {
        "id": "yFh3Wj0t",
        "title": "Three solutions for forced duffing-type equations with damping term",
        "abstract": "Using the variational principle of Ricceri and a local mountain pass lemma, we study the existence of three distinct solutions for the following resonant Duffing-type equations with damping and perturbed term u″(t)+ αu′(t) + f (t,u(t)) + λg (t,u(t)) = p (t), a.e. t ∈ [ 0,w], u(0) = 0 = u (w) and without perturbed term u″ (t) + αu′(t) + f (t,u(t)) = p(t), a.e. t∈ [ 0,w], u (0) = 0 = u (w). © 2011 Yongkun Li and Tianwei Zhang.",
        "keywords": [
            "Variational Principle",
            " Mountain Pass",
            " Critical Point Theory",
            " Distinct Solution",
            " Chaotic Synchronization"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Tianwei Zhang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2011
    },
    "XsFtBod0": {
        "id": "XsFtBod0",
        "title": "POSITIVE PERIODIC SOLUTIONS OF NEUTRAL FUNCTIONAL DIFFERENTIAL EQUATIONS WITH A PARAMETER AND IMPULSE",
        "abstract": "In this paper, we consider first-order neutral dierential equations with a parameter and impulse in the form of d dt (x(t) cx(t )) = a(t)g(x(h 1(t)))x(t) + b (t)fx(h2(t)) ´ , t 6= tj; ˆ x(t) cx(t ) ˜ = I j ` x(t) ´ , t = t j, j 2 Z +. Leggett-Williams fixed point theorem, we prove the existence of three positive periodic solutions.",
        "keywords": [
            ". periodic solution",
            "functional dierential"
        ],
        "authors": [
            {
                "name": "XUANLONG FAN",
                "org": ""
            },
            {
                "name": "YONGKUN LI",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "R1JIZZBu": {
        "id": "R1JIZZBu",
        "title": "Positive periodic solutions of periodic neutral Lotka–Volterra system with state dependent delays",
        "abstract": "By using a fixed point theorem of strict-set-contraction, some new criteria are established for the existence of positive periodic solutions of the following periodic neutral Lotka–Volterra system with state dependent delaysdxi(t)dt=xi(t)[ri(t)−∑j=1naij(t)xj(t)−∑j=1nbij(t)xj(t−τij(t,x1(t),…,xn(t)))−∑j=1ncij(t)xj′(t−σij(t,x1(t),…,xn(t)))],i=1,2,…,n, where ri,aij,bij,cij∈C(R,R+) (i,j=1,2,…,n) are ω-periodic functions and τij,σij∈C(Rn+1,R) (i=1,2,…,n) are ω-periodic functions with respect to their first arguments, respectively.",
        "keywords": [
            "Positive periodic solution",
            "Neutral functional differential equation",
            "Lotka–Volterra system",
            "k-Set contraction"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2007
    },
    "NuWJoo47": {
        "id": "NuWJoo47",
        "title": "Robust stability of delayed reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales",
        "abstract": "In this paper, the global robust exponential stability of equilibrium solution to delayed reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales is studied. Using topological degree theory, M-matrix method, Lyapunov functional and inequality skills, we establish some sufficient conditions for the existence, uniqueness and global robust exponential stability of equilibrium solution to delayed reaction-diffusion recurrent neural networks with Dirichlet boundary conditions on time scales. One example is given to illustrate the effectiveness of our results.",
        "keywords": [
            "sufficient condition",
            "robust stability",
            "inequality skill",
            "m-matrix method",
            "dirichlet boundary condition",
            "time scales",
            "delayed reaction–diffusion recurrent neural networks",
            "global robust exponential stability",
            "equilibrium solution",
            "topological degree theory",
            "delayed reaction-diffusion recurrent neural",
            "dirichlet boundary conditions",
            "time scale",
            "lyapunov function",
            "neural network",
            "exponential stability",
            "reaction diffusion",
            "recurrent neural network"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Kaihong Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China and Department of Applied Mathematics, Kunming University of Science and Technology, Kunming, Yunna ..."
            }
        ],
        "venue": "Neurocomputing",
        "year": 2011
    },
    "PauPvnm0": {
        "id": "PauPvnm0",
        "title": "Multiple Positive Periodic Solutions to a Predator-prey system with Harvesting Terms and Holling II Type Functional Response",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pan wang",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "qVJTrvfS": {
        "id": "qVJTrvfS",
        "title": "Existence of positive periodic solutions for a functional difference equation",
        "abstract": "By using Krasonoselskii's fixed point theorem,some sufficient conditions are obtained for the existence of at least one or at least two positive T-periodic solutions for a functional difference equation.",
        "keywords": [
            "functional difference equation",
            "positive periodic solution",
            "fixed point theorem"
        ],
        "authors": [
            {
                "name": "YANG Li",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            },
            {
                "name": "LI Yong-kun",
                "org": "Department of Mathematics,Yunnan University,Kunming ,China"
            }
        ],
        "venue": "Journal of Yunnan University(Natural Sciences Edition)",
        "year": 2009
    },
    "HAg6taS7": {
        "id": "HAg6taS7",
        "title": "Existence and stability of positive periodic solution for BAM neural networks with delays",
        "abstract": "In this paper, we use Krasnosel'skii's fixed-point theorem in cones and Lyapunovfunctions to study the existence and stability of a positive periodic solution for a class of two-layer heteroassociative networks called bidirectional associative memory (BAM) networks with state dependent delays dxidt=−ai(t)xi(t)+∑j=1mcji(t)fj(yj(αji(t,yj(t))))+Ii(t),dyjdt=−bj(t)yj(t)+∑i=1ndij(t)fi(xi(βij(t,xi(t))))+Jj(t), where i = 1,2,, n, j =m.",
        "keywords": [
            "State dependent delay",
            "Differential equation",
            "Positive periodic solution",
            "Stability",
            "BAM neural networks"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Author to whom all correspondence should be addressed at yklie@ynu. edu. cn."
            },
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, P.R. China"
            }
        ],
        "venue": "Mathematical and Computer Modelling",
        "year": 2004
    },
    "9j4MMdSC": {
        "id": "9j4MMdSC",
        "title": "OSCILLATION OF A SECOND-ORDER DIFFERENCE EQUATION WITH A NONLINEAR DAMPED TERM IN ARCHIMEDEAN SPACE",
        "abstract": "In Archimedean space (X;`) we study oscillation of all solutions of the second-order difference equation with a nonlinear damped term of the form",
        "keywords": [
            "second-order difference equation",
            "order relation",
            "oscillation.",
            "second order",
            "oscillations",
            "difference equation"
        ],
        "authors": [
            {
                "name": "YONGKUN LI",
                "org": "Department of Mathematics|Yunnan University"
            },
            {
                "name": "LILI ZHAO",
                "org": "Department of Mathematics|Yunnan University"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "MOts3Jlk": {
        "id": "MOts3Jlk",
        "title": "Almost periodic synchronization of quaternion-valued shunting inhibitory cellular neural networks with mixed delays via state-feedback control.",
        "abstract": "This paper studies the drive-response synchronization for quaternion-valued shunting inhibitory cellular neural networks (QVSICNNs) with mixed delays. First, QVSICNN is decomposed into an equivalent real-valued system in order to avoid the non-commutativity of the multiplicity. Then, the existence of almost periodic solutions is obtained based on the Banach fixed point theorem. An novel state-feedback controller is designed to ensure the global exponential almost periodic synchronization. At the end of the paper, an example is given to illustrate the effectiveness of the obtained results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China."
            },
            {
                "name": "Huimei Wang",
                "org": "Department of Mathematics, Kunming University, Kunming, Yunnan 650214, China."
            }
        ],
        "venue": "PloS one",
        "year": 2018
    },
    "izwiLtAs": {
        "id": "izwiLtAs",
        "title": "Pseudo almost periodic solutions for quaternion-valued cellular neural networks with discrete and distributed delays.",
        "abstract": "This paper is concerned with a class of quaternion-valued cellular neural networks with discrete and distributed delays. By using the exponential dichotomy of linear systems and a fixed point theorem, sufficient conditions are derived for the existence and global exponential stability of pseudo almost periodic solutions of this class of neural networks. Finally, a numerical example is given to illustrate the feasibility of the obtained results.",
        "keywords": [
            "Distributed delay",
            "Exponent stability",
            "Pseudo almost periodic solutions",
            "Quaternion-valued cellular neural networks"
        ],
        "authors": [
            {
                "name": "Xiaofang Meng",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China."
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People's Republic of China."
            }
        ],
        "venue": "Journal of inequalities and applications",
        "year": 2018
    },
    "jsQNjX8N": {
        "id": "jsQNjX8N",
        "title": "Existence of solutions for a fractional differential equations with integral boundary value problem at resonance on the half-line",
        "abstract": "In this paper, some sufficient conditions are obtained for the existence of solutions for a fractional differential equation with integral boundary value problem at resonance on the half-line. By constructing a suitable Banach space, defining appropriate operators and using the coincidence degree theory due to Mawhin, some new sufficient conditions are obtained, which generalise and enrich some known results.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Yanning Wang",
                "org": ""
            }
        ],
        "venue": "International Journal of Dynamical Systems and Differential Equations",
        "year": 2016
    },
    "9zqVJHJh": {
        "id": "9zqVJHJh",
        "title": "Existence and exponential stability of positive almost periodic solution for Nicholson's blowflies models on time scales",
        "abstract": "In this paper, we first give a new definition of almost periodic time scales, two new definitions of almost periodic functions on time scales and investigate some basic properties of them. Then, as an application, by using a fixed point theorem in Banach space and the time scale calculus theory, we obtain some sufficient conditions for the existence and exponential stability of positive almost periodic solutions for a class of Nicholson's blowflies models on time scales. Finally, we present an illustrative example to show the effectiveness of obtained results. Our results show that under a simple condition the continuous-time Nicholson's blowflies model and its discrete-time analogue have the same dynamical behaviors. ",
        "keywords": [
            "Almost periodic solution",
            "Almost periodic time scales",
            "Exponential stability",
            "Nicholsons blowflies model"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "bing li",
                "org": ""
            }
        ],
        "venue": "SpringerPlus",
        "year": 2015
    },
    "Imrcml4b": {
        "id": "Imrcml4b",
        "title": "-Almost Periodic Solutions of BAM Neural Networks with Time-Varying Delays on Time Scales",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "lili zhao",
                "org": ""
            },
            {
                "name": "li yang",
                "org": ""
            }
        ],
        "venue": "The Scientific World Journal",
        "year": 2015
    },
    "6v0EZgsG": {
        "id": "6v0EZgsG",
        "title": "Existence and global exponential stability of periodic solutions for n-dimensional neutral dynamic equations on time scales.",
        "abstract": "In this paper, by using the existence of the exponential dichotomy of linear dynamic equations on time scales and the theory of calculus on time scales, we study the existence and global exponential stability of periodic solutions for a class of n-dimensional neutral dynamic equations on time scales. We also present an example to illustrate the feasibility of our results. The results of this paper are completely new and complementary to the previously known results even in both the case of differential equations (time scale \n                  \n                    \n                  \n                  $${\\mathbb {T}}={\\mathbb {R}}$$\n                  \n                    \n                  \n                ) and the case of difference equations (time scale \n                  \n                    \n                  \n                  $${\\mathbb {T}}={\\mathbb {Z}}$$\n                  \n                    \n                  \n                ).",
        "keywords": [
            "Periodic solution",
            " Neutral delay",
            " Exponential stability",
            " \n                        n-Dimensional neutral dynamic equations",
            " Time scale",
            " 34K13",
            " 34K20",
            " 34K40",
            " 34N05"
        ],
        "authors": [
            {
                "name": "Bing Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, People’s Republic of China"
            },
            {
                "name": "Xuemei Zhang",
                "org": "School of Mathamatics and Information Science, Qujing Normal University, Qujing, People’s Republic of China"
            }
        ],
        "venue": "SpringerPlus",
        "year": 2016
    },
    "O0XG341c": {
        "id": "O0XG341c",
        "title": "Global Exponential Stability of Weighted Pseudo-Almost Periodic Solutions of Neutral Type High-Order Hopfield Neural Networks with Distributed Delays",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lili zhao",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2014
    },
    "nYfD4KIo": {
        "id": "nYfD4KIo",
        "title": "Existence of positive periodic solutions for a periodic logistic equation",
        "abstract": "In this paper, we study a more generalized class of periodic logistic equations. By using the method of coincidence degree, a set of sufficient conditions is obtained for the existence of positive periodic solutions of the equations which are under the consideration.",
        "keywords": [
            "State dependent delay",
            "Logistic equation",
            "Distributed delay",
            "Periodic solution"
        ],
        "authors": [
            {
                "name": "Guihong Fan",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2003
    },
    "bys08PCd": {
        "id": "bys08PCd",
        "title": "Variational approach to a class of p-Laplacian systems on time scales",
        "abstract": "In this paper, we present a recent approach via variational methods and critical point theory to obtain the existence of nontrivial periodic solutions for a class of p-Laplacian systems on time scales. By establishing a proper variational setting, three existence results are obtained. Finally, two examples are presented to illustrate the feasibility and effectiveness of our results.",
        "keywords": [
            "variational approach",
            " time scales",
            " p-Laplacian systems",
            " critical points"
        ],
        "authors": [
            {
                "name": "jianwen zhou",
                "org": "yunnan university"
            },
            {
                "name": "yongkun li",
                "org": "yunnan university"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2013
    },
    "aa4VYhr3": {
        "id": "aa4VYhr3",
        "title": "Asymptotical stability of almost periodic solution for an impulsive multispecies competition–predation system with time delays on time scales",
        "abstract": "In this paper, we consider the almost periodic dynamics of an impulsive multispecies Lotka-Volterra competition system with time delays on time scales. By establishing some comparison theorems of dynamic equations with impulses and delays on time scales, a permanence result for the model is obtained. Furthermore, based on the permanence result, by studying the Lyapunov stability theory of impulsive dynamic equations on time scales, we establish the existence and uniformly asymptotic stability of a unique positive almost periodic solution of the system. Finally, we give an example to show the feasibility of our main results, and our example also shows that the continuous time system and its corresponding discrete time system have the same dynamics. Our results of this paper are completely new even if for both the case of the time scale T=R and the case of the time scale T=Z. Copyright (C) 2017 John Wiley & Sons, Ltd.",
        "keywords": [
            "multispecies competition-predation system",
            "impulse",
            "permanence",
            "almost periodic solution",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan, China"
            },
            {
                "name": "Pan Wang",
                "org": "Yunnan University Department of Mathematics Kunming Yunnan China"
            },
            {
                "name": "Pan Wang",
                "org": "Yunnan University Department of Mathematics Kunming Yunnan China"
            }
        ],
        "venue": "MATHEMATICAL METHODS IN THE APPLIED SCIENCES",
        "year": 2017
    },
    "E3FrdX1b": {
        "id": "E3FrdX1b",
        "title": "Existence and global exponential stability of anti-periodic solutions for generalised inertial competitive neural networks with time-varying delays",
        "abstract": "In this paper, a class of generalised inertial competitive neural networks with time-varying delays is proposed. The existence and global exponential stability of anti-periodic solutions for this class of neural networks are investigated. By using a continuation theorem of coincidence degree theory, the Wirtinger inequality and constructing an appropriate Lyapunov function, some sufficient conditions are derived to guarantee the existence, uniqueness, and global exponential stability of anti-periodic solutions for the considered networks. Our results are completely new.",
        "keywords": [
            "Inertial term",
            "competitive neural network",
            "coincidence degree",
            "anti-periodic solution",
            "time-varying delay"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Jiali Qin",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF EXPERIMENTAL & THEORETICAL ARTIFICIAL INTELLIGENCE",
        "year": 2020
    },
    "z2fVVXge": {
        "id": "z2fVVXge",
        "title": "Global asymptotical stability of a unique almost periodic solution for enterprise clusters based on ecology theory with time-varying delays and feedback controls",
        "abstract": "This paper is concerned with some dynamic behavior of enterprises cluster constituted by n satellite enterprises and a dominant enterprise. We present a model involving time-varying delays and feedback controls based on ecology theory, which effectively describe the competition and cooperation of enterprises cluster in real economic environments. Applying the comparison theorem of differential equations and constructing a suitable Lyapunov functional, sufficient conditions which guarantee the existence of a unique globally asymptotically stable nonnegative almost periodic solution of the system are obtained. Finally, we present an example to explain the economical significance of mathematical results. © 2011 Elsevier B.V.",
        "keywords": [
            "Enterprise cluster",
            "Stability",
            "Almost periodic solution",
            "Delay",
            "Feedback control"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2012
    },
    "RDWRKs9Q": {
        "id": "RDWRKs9Q",
        "title": "Existence and exponential stability of an equilibrium point for fuzzy BAM neural networks with time-varying delays in leakage terms on time scales",
        "abstract": "In this paper, by using a fixed point theorem and differential inequality techniques, we consider the existence and global exponential stability of an equilibrium point for a class of fuzzy bidirectional associative memory neural networks with time-varying delays in leakage terms on time scales. We also present a numerical example to show the feasibility of obtained results. The results of this paper are completely new and complementary to the previously known results. © 2013 Li et al.; licensee Springer.",
        "keywords": [
            "exponential stability",
            "fuzzy bam neural networks",
            "leakage terms",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Li Yang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Lijie Sun",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2013
    },
    "e5OQdNkk": {
        "id": "e5OQdNkk",
        "title": "Periodic solutions for impulsive stochastic BAM neural networks with time-varying delays in leakage terms",
        "abstract": "By using an integral inequality, we establish some sufficient conditions for the existence and p-exponential stability of periodic solutions for a class of impulsive stochastic BAM neural networks with time-varying delays in leakage terms. Moreover, we present an example to illustrate the feasibility of our results. © 2013 Li Yang and Yongkun Li.",
        "keywords": [],
        "authors": [
            {
                "name": "Li Yang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "International Journal of Differential Equations",
        "year": 2013
    },
    "ZkgEzcbt": {
        "id": "ZkgEzcbt",
        "title": "Anti-periodic solution for fuzzy Cohen-Grossberg neural networks with time-varying and distributed delays",
        "abstract": "In this paper, by using a continuation theorem of coincidence degree theory and a differential inequality, we establish some sufficient conditions ensuring the existence and global exponential stability of anti-periodic solutions for a class of fuzzy Cohen-Grossberg neural networks with time-varying and distributed delays. In addition, we present an illustrative example to show the feasibility of obtained results.",
        "keywords": [
            "Cohen-Grossberg neural networks",
            "exponential stability",
            "anti-periodic solutions",
            "coincidence degree"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Li Yang",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Wanqin Wu",
                "org": "Yunnan Nationalities Univ, Sch Math & Comp Sci, Kunming 650091, Yunnan, Peoples R China"
            }
        ],
        "venue": "NONLINEAR ANALYSIS-MODELLING AND CONTROL",
        "year": 2015
    },
    "rcz7v7YN": {
        "id": "rcz7v7YN",
        "title": "Cn-Almost Periodic Functions and an Application to a Lasota-Wazewska Model on Time Scales.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Li Yang",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Wanqin Wu",
                "org": ""
            }
        ],
        "venue": "J. Applied Mathematics",
        "year": 2014
    },
    "tKS6xDPB": {
        "id": "tKS6xDPB",
        "title": "Multiple positive solutions for a fourth-order integral boundary value problem on time scales",
        "abstract": "Abstract In this article, we investigate the multiplicity of positive solutions for a fourth-order system of integral boundary value problem on time scales. The existence of multiple positive solutions for the system is obtained by using the fixed point theorem of cone expansion and compression type due to Krasnosel'skill. To demonstrate the applications of our results, an example is also given in the article.",
        "keywords": [
            "positive solutions",
            "fixed points",
            "integral boundary conditions",
            "time scales"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan, 650091, People’s Republic of China"
            },
            {
                "name": "Yanshou Dong",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan, 650091, People’s Republic of China"
            }
        ],
        "venue": "Boundary Value Problems",
        "year": 2011
    },
    "wZOtsZqy": {
        "id": "wZOtsZqy",
        "title": "Existence and finite-time stability of a unique almost periodic positive solution for fractional-order Lasota-Wazewska red blood cell models",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Yaolu Wang",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2020
    },
    "TNahcmGa": {
        "id": "TNahcmGa",
        "title": "Pseudo almost periodic functions and pseudo almost periodic solutions to dynamic equations on time scales",
        "abstract": "In this paper, we first introduce a concept of the mean-value of uniformly almost periodic functions on time scales and give some of its basic properties. Then, we propose a concept of pseudo almost periodic functions on time scales and study some basic properties of pseudo almost periodic functions on time scales. Finally, we establish some results about the existence of pseudo almost periodic solutions to dynamic equations on time scales. © 2012 Li and Wang.",
        "keywords": [
            "dynamic equations on time scales",
            "exponential dichotomy",
            "pseudo almost periodic functions",
            "pseudo almost periodic solutions",
            "difference"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Chao Wang",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2012
    },
    "JcDNZV9t": {
        "id": "JcDNZV9t",
        "title": "Persistence and almost periodic solutions for a discrete fishing model with feedback control☆",
        "abstract": "In this paper, we discuss an almost periodic discrete fishing model with feedback control of the form",
        "keywords": [
            "Persistence",
            "Almost periodic solution",
            "Discrete fishing model"
        ],
        "authors": [
            {
                "name": "Tianwei Zhang",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yuan Ye",
                "org": "Graduate School of Yunnan University, Yunnan University Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "29SlgVhS": {
        "id": "29SlgVhS",
        "title": "Exponential stability of fuzzy Cohen–Grossberg neural networks with time delays and impulsive effects☆",
        "abstract": "In this paper, we investigate a class of fuzzy Cohen-Grossberg neural networks with time delays and impulsive effects. By employing an inequality technique, we find sufficient conditions for the existence, uniqueness, global exponential stability of the equilibrium without using the M-matrix theory. An example is given to illustrate the effectiveness of the obtained results.",
        "keywords": [
            "Fuzzy Cohen–Grossberg neural networks (FCGNNs)",
            "Global exponential stability",
            "Time delays",
            "Impulsive effects"
        ],
        "authors": [
            {
                "name": "Changzhao Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Yuan Ye",
                "org": "Graduate School of Yunnan University, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "2c1ctUXU": {
        "id": "2c1ctUXU",
        "title": "Positive solutions of nonlocal boundary value problem for nonlinear retarded differential equation",
        "abstract": "By using Krasnoselskii’s fixed-point theorem on a suitable cone, several existence results and corresponding properties of\n positive solutions of nonlocal boundary value problem for nonlinear retarded differential equation are obtained.",
        "keywords": [
            "34K10",
            "positive solution",
            "retarded differential equation",
            "nonlocal boundary value problem",
            "Krasnoselskii’s fixed-point theorem"
        ],
        "authors": [
            {
                "name": "Ping Liu",
                "org": "Yunnan Univ. Dept. of Math. 650091 Kunming China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ. Dept. of Math. 650091 Kunming China"
            },
            {
                "name": "Linghong Lu",
                "org": "Yunnan Univ. Dept. of Math. 650091 Kunming China"
            }
        ],
        "venue": "Applied Mathematics-A Journal of Chinese Universities",
        "year": 2004
    },
    "DlKzW3jz": {
        "id": "DlKzW3jz",
        "title": "Positive periodic solutions for a class of higher-dimensional state-dependent delay functional differential equations with feedback control",
        "abstract": "We use the Krasnosel'skii's fixed point theorem for cones to study the existence of positive periodic solutions of the following a class of higher-dimensional state-dependent delay functional differential equations with feedback controlx@?(t)=-A(t)x(t)+f(t,x\\\"t,x(t-@t(t,x(t))),u(t-@a(t))),u@?(t)=-B(t)u(t)+C(t)x(h(t,x(t))). Moreover, we apply our results obtained in this paper to some population model.",
        "keywords": [
            "fixed point theorem",
            "feedback control",
            "positive periodic solution",
            "state-dependent delay",
            "population model"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author"
            },
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University, Cuihu Beilu 2, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2004
    },
    "gPHpxTs2": {
        "id": "gPHpxTs2",
        "title": "Pseudo almost automorphic solutions of quaternion-valued neural networks with infinitely distributed delays via a non-decomposing method",
        "abstract": "In this paper, we consider the existence and global exponential stability of pseudo almost automorphic solutions to quaternion-valued cellular neural networks with infinitely distributed delays. Unlike most previous studies of quaternion-valued cellular neural networks, we do not decompose the systems under consideration into real-valued or complex-valued systems, but rather directly study quaternion-valued systems. Our method and the results of this paper are new. An example is given to show the feasibility of our main results.",
        "keywords": [
            "Pseudo almost automorphic solution",
            " Global exponential stability",
            " Quaternion-valued neural networks"
        ],
        "authors": [
            {
                "name": "Jianglian Xiang",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2019
    },
    "skkwixQj": {
        "id": "skkwixQj",
        "title": "Existence and global attractivity of a positive periodic solution of a class of delay differential equation",
        "abstract": "The existence and the global attractivity of a positive periodic solution of the delay differential equationy(t)=y(t) F[t, y](t-τ\n 1\n (t)),⋯,y(t−τ\n n\n (t))] are studied by using some techniques of the Mawhin coincidence degree theory and the constructing suitable Liapunov functionals.\n When these results are applied to some special delay bio-mathematics models, some new results are obtained, and many known\n results are improved.",
        "keywords": [
            "positive periodic solution",
            "logistic equation",
            "delay differential equation",
            "fredholm mapping.",
            "global attractivity",
            "mathematical model"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan University Department of Mathematics 650091 Kunming China"
            }
        ],
        "venue": "Science China-mathematics",
        "year": 1998
    },
    "ZNIAWYbk": {
        "id": "ZNIAWYbk",
        "title": "Positive almost periodic solutions for a time-varying fishing model with delay",
        "abstract": "This paper is concerned with a time-varying fishing model with delay. By means of the continuation theoremof coincidence degree theory, we prove that it has at least one positive almost periodic solution. Copyright © 2011 Xia Li et al.",
        "keywords": [],
        "authors": [
            {
                "name": "Xia Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Chunyan He",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            }
        ],
        "venue": "International Journal of Differential Equations",
        "year": 2011
    },
    "YfYfhYWJ": {
        "id": "YfYfhYWJ",
        "title": "An Application of Variational Approach to Delay Hamiltonian Systems on Time Scales with Impulses",
        "abstract": "In this paper, we present a recent approach via variational methods and critical point theory to obtain the existence of periodic solutions for a class of delay Hamiltonian systems on time scales with impulsive effects. The variational principle is given, and some existence theorems and two multiplicity results of periodic solutions are obtained. Finally, one example is presented to illustrate the feasibility and effectiveness of our results. Our results are new even in both the differential equations case and the difference equations case.",
        "keywords": [
            "Delay Hamiltonian systems",
            "Time scales",
            "Impulse",
            "Variational approach",
            "34N05",
            "34K45",
            "37J45"
        ],
        "authors": [
            {
                "name": "jianwen zhou",
                "org": "yunnan university"
            },
            {
                "name": "yongkun li",
                "org": "yunnan university"
            },
            {
                "name": "yanning wang",
                "org": "yunnan university"
            }
        ],
        "venue": "Bulletin of the Malaysian Mathematical Sciences Society",
        "year": 2015
    },
    "UDsddCKu": {
        "id": "UDsddCKu",
        "title": "GLOBAL EXPONENTIAL STABILITY OF ALMOST PERIODIC SOLUTIONS OF HIGH-ORDER HOPFIELD NEURAL NETWORKS WITH DISTRIBUTED DELAYS OF NEUTRAL TYPE",
        "abstract": "",
        "keywords": [
            "fixed point theorem"
        ],
        "authors": [
            {
                "name": "lili zhao",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "lTDnw32P": {
        "id": "lTDnw32P",
        "title": "Almost Periodic Synchronization of Fuzzy Cellular Neural Networks with Time-Varying Delays via State-Feedback and Impulsive Control.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Huimei Wang",
                "org": ""
            },
            {
                "name": "Xiaofang Meng",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics and Computer Science",
        "year": 2019
    },
    "dfyvGhFk": {
        "id": "dfyvGhFk",
        "title": "Pseudo-almost-periodic solutions of quaternion-valued RNNs with mixed delays via a direct method",
        "abstract": "In this paper, we are concerned with the existence and global exponential stability of pseudo-almost-periodic solutions for quaternion-valued recurrent neural networks (RNNs) with time-varying delays. By using the Banach fixed point theorem and proof by contradiction, we directly study the existence and exponential stability of pseudo-almost-periodic solutions of the quaternion-valued systems under consideration without decomposing them into into real- or complex-valued systems. Our results obtained in this paper are new. Finally, we give a numerical example and computer simulation to illustrate the feasibility of our results.",
        "keywords": [
            "Pseudo-almost-periodic solution",
            " Quaternion-valued neural networks",
            " Global exponential stability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            },
            {
                "name": "Jianglian Xiang",
                "org": "Department of Mathematics, Yunnan University, Kunming, China"
            },
            {
                "name": "Bing Li",
                "org": "School of Mathematics and Computer Science, Yunnan Mizu University, Kunming, China"
            }
        ],
        "venue": "Journal of Inequalities and Applications",
        "year": 2020
    },
    "TFWdcgxk": {
        "id": "TFWdcgxk",
        "title": "Bifurcation Analysis for a Two-Dimensional Discrete-Time Hopfield Neural Network with Delays",
        "abstract": "",
        "keywords": [
            "discrete time"
        ],
        "authors": [
            {
                "name": "Yaping Ren",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            }
        ],
        "venue": "Int. J. Math. Mathematical Sciences",
        "year": 2007
    },
    "Gxh7kRNO": {
        "id": "Gxh7kRNO",
        "title": "Four positive periodic solutions of a discrete time Lotka-Volterra competitive system with harvesting terms",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xinggui liu",
                "org": ""
            },
            {
                "name": "yaping ren",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            }
        ],
        "venue": "Opuscula Mathematica",
        "year": 2011
    },
    "tOvO5Vsr": {
        "id": "tOvO5Vsr",
        "title": "Positive periodic solutions of neutral logistic equations with distributed delays",
        "abstract": "Using a fixed point theorem of strict-set-contraction, we establish criteria for the existence of positive periodic solutions for the periodic neutral logistic equation, with distributed delays, x′(t) = x(t)[a(t)-∑i=1 nai(t)∫ -Ti 0x(t+θ)dμi(θ)-∑ j=1 mbj(t)∫-T̂j 0x′(t+θ)dvj(θ), where the coefficients a, ai, bj are continuous and periodic functions, with the same period. The values Ti,T̂j are positive, and the functions μi,vj are nondecreasing with ∫-Ti 0 dμi = 1 and ∫ -Ti 0dvj = 1. © 2006 Texas State University.",
        "keywords": [
            "fixed point theorem",
            "logistic equation"
        ],
        "authors": [
            {
                "name": "YONGKUN LI",
                "org": ""
            },
            {
                "name": "Wang Guoqiao",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "HUIMEI WANG",
                "org": ""
            }
        ],
        "venue": "Electronic Journal of Differential Equations",
        "year": 2007
    },
    "3NiYtvv7": {
        "id": "3NiYtvv7",
        "title": "Anti-periodic Synchronization of Quaternion-valued Generalized Cellular Neural Networks with Time-varying Delays and Impulsive Effects",
        "abstract": "In this paper, a class of quaternion-valued generalized cellular neural networks (QVGCNNs) with time-varying delays and impulsive effects is considered. Firstly, by constructing an appropriate Lyapunov function and applying inequality techniques, some sufficient conditions on the existence of anti-periodic solutions are established. Then, the global exponential anti-periodic synchronization of delayed QVGCNNs with impulsive effects and anti-periodic coefficients is investigated by designing a novel nonlinear state-feedback controller and constructing suitable Lyapunov functions. Our results are completely new even if the considered quaternion-valued systems degenerated into real-valued or complex-valued systems. Finally, two numerical examples are given to illustrate the feasibility and effectiveness of the obtained results.",
        "keywords": [
            "Anti-periodic solution",
            " generalized cellular neural network",
            " quaternion",
            " synchronization"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics,Yunnan University,Kunming, Yunnan,P. R. China"
            },
            {
                "name": "Yanchao Fang",
                "org": "Department of Mathematics,Yunnan University,Kunming, Yunnan,P. R. China"
            },
            {
                "name": "Jiali Qin",
                "org": "Department of Mathematics,Yunnan University,Kunming, Yunnan,P. R. China"
            }
        ],
        "venue": "International Journal of Control, Automation and Systems",
        "year": 2019
    },
    "WiakCfM1": {
        "id": "WiakCfM1",
        "title": "Positive periodic solutions of a class of functional differential systems with feedback controls",
        "abstract": "In this paper, by using the upper and lower solutions method, we investigate the existence and nonexistence of positive periodic solutions of infinite delay functional differential system with a parameter and feedback controlsẋ(t)=A(t)x(t)−λF(t,xt,x(g(t,x(t))),u(α(t,x(t)))),u̇(t)=−B(t)u(t)+E(t,xt,x(h(t,x(t)))).",
        "keywords": [
            "Delay differential equation",
            "Feedback control",
            "Upper and lower solutions method",
            "Positive periodic solution",
            "State-dependent delay"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +86-08715033701; fax: +86-08715147713"
            },
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University, Cuihu Beilu 2, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University, Cuihu Beilu 2, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2004
    },
    "8Xx5s6tJ": {
        "id": "8Xx5s6tJ",
        "title": "Existence and Exponential Stability of Periodic Solution for a Class of Generalized Neural Networks with Arbitrary Delays",
        "abstract": "By the continuation theoremof coincidence degree and M-matrix theory, we obtain some sufficient conditions for the existence and exponential stability of periodic solutions for a class of generalized neural networks with arbitrary delays, which are milder and less restrictive than those of previous known criteria. Moreover our results generalize and improve many existing ones. Copyright (C) 2009 Yimin Zhang et al.",
        "keywords": [
            "exponential stability",
            "matrix theory",
            "neural network"
        ],
        "authors": [
            {
                "name": "Yimin Zhang",
                "org": "Zhaotong Teachers Coll, Dept Math, Zhaotong 657000, Yunnan, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650091, Yunnan, Peoples R China"
            },
            {
                "name": "Kuohui Ye",
                "org": "Department of Mathematics|Yunnan University"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2009
    },
    "rja6otFh": {
        "id": "rja6otFh",
        "title": "C1-almost periodic solutions of BAM neural networks with time-varying delays on time scales.",
        "abstract": "On a new type of almost periodic time scales, a class of BAM neural networks is considered. By employing a fixed point theorem and differential inequality techniques, some sufficient conditions ensuring the existence and global exponential stability of C(1)-almost periodic solutions for this class of networks with time-varying delays are established. Two examples are given to show the effectiveness of the proposed method and results.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China."
            },
            {
                "name": "Lili Zhao",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China."
            },
            {
                "name": "Li Yang",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, China."
            }
        ],
        "venue": "TheScientificWorldJournal",
        "year": 2015
    },
    "2CMwCdBz": {
        "id": "2CMwCdBz",
        "title": "Periodic Solutions for Shunting Inhibitory Cellular Neural Networks of Neutral Type with Time-Varying Delays in the Leakage Term on Time Scales.",
        "abstract": "A class of shunting inhibitory cellular neural networks of neutral type with time-varying delays in the leakage term on time scales is proposed. Based on the exponential dichotomy of linear dynamic equations on time scales, fixed point theorems, and calculus on time scales we obtain some sufficient conditions for the existence and global exponential stability of periodic solutions for that class of neural networks. The results of this paper are completely new and complementary to the previously known results even if the time scale T = R or Z. Moreover, we present illustrative numerical examples to show the feasibility of our results.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Dept Math, Kunming 650221, Yunnan, Peoples R China"
            },
            {
                "name": "Lei Wang",
                "org": "Yunnan Univ, Dept Math, Kunming 650221, Yunnan, Peoples R China"
            },
            {
                "name": "Yu Fei",
                "org": "Yunnan Univ Finance & Econ, Sch Math & Stat, Kunming 650221, Yunnan, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF APPLIED MATHEMATICS",
        "year": 2014
    },
    "dJZ5KTFE": {
        "id": "dJZ5KTFE",
        "title": "Existence and stability of periodic solutions of delayed cellular neural networks",
        "abstract": "We use the continuation theorem of coincidence degree theory and Liapunov function to study the existence and stability of positive periodic solutions for cellular neural networks (CNNs) with distributed delays dxidt=-bi(t)xi(t)+∑j=1naij(t)fj(xj(t))+∑j=1nbij(t)fj(xj(ζij(t,xj(t))))+Ii(t),i=1,2,…,nand cellular neural networks (CNNs) with state-dependent delays dxidt=-bi(t)xi(t)+∑j=1naij(t)fj(xj(t))+∑j=1nbij(t)fj∫0∞kij(u)xj(t-u)du+Ii(t),i=1,2,…,n.",
        "keywords": [
            "Cellular neural networks (CNNs)",
            "State-dependent delay",
            "Periodic solution",
            "Stability",
            "Coincidence degree"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: 08608715033701; fax: 08608715032576."
            },
            {
                "name": "Lifei Zhu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Ping Liu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2006
    },
    "Yi9OhqgN": {
        "id": "Yi9OhqgN",
        "title": "Understanding Persuasion Cascades in Online Product Rating Systems",
        "abstract": "Online product rating systems have become an indispensable component for numerous web services such as Amazon, eBay, Google play store and TripAdvisor. One functionality of such systems is to uncover the product quality via product ratings (or reviews) contributed by consumers. However, a well-known psychological phenomenon called \"message-based persuasion\" lead to \"biased\" product ratings in a cascading manner (we call this the persuasion cascade). This paper investigates: (1) How does the persuasion cascade influence the product quality estimation accuracy? (2) Given a real-world product rating dataset, how to infer the persuasion cascade and analyze it to draw practical insights? We first develop a mathematical model to capture key factors of a persuasion cascade. We formulate a high-order Markov chain to characterize the opinion dynamics of a persuasion cascade and prove the convergence of opinions. We further bound the product quality estimation error for a class of rating aggregation rules including the averaging scoring rule, via the matrix perturbation theory and the Chernoff bound. We also design a maximum likelihood algorithm to infer parameters of the persuasion cascade. We conduct experiments on the data from Amazon and TripAdvisor, and show that persuasion cascades notably exist, but the average scoring rule has a small product quality estimation error under practical scenarios.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Xie",
                "org": "Chongqing Univ, Coll Comp Sci, Chongqing, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Univ Sci & Technol China, Sch Comp Sci & Technol, Hefei, Anhui, Peoples R China"
            },
            {
                "name": "John C. S. Lui",
                "org": "Chinese Univ Hong Kong, Dept Comp Sci & Engn, Hong Kong, Peoples R China"
            }
        ],
        "venue": "THIRTY-THIRD AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE / THIRTY-FIRST INNOVATIVE APPLICATIONS OF ARTIFICIAL INTELLIGENCE CONFERENCE / NINTH AAAI SYMPOSIUM ON EDUCATIONAL ADVANCES IN ARTIFICIAL INTELLIGENCE",
        "year": 2019
    },
    "BjXNVnWH": {
        "id": "BjXNVnWH",
        "title": "DCS: Diagonal Coding Scheme for Enhancing the Endurance of SSD-Based RAID Arrays.",
        "abstract": "To guarantee high reliability, solid-state drive (SSD)-based storage systems require data redundancy schemes, e.g., redundant array of independent disks (RAID) schemes. Traditional RAID-5, RAID-6, and Reed-Solomon codes can tolerate one, two, and an arbitrary number of device failures, respectively. However, some SSDs under those redundant configurations may age much faster than others because of the high skewness and locality of workloads. The uneven aging rates may make some SSDs wear out very quickly and decrease the endurance of SSD-based RAID arrays. To address this problem, we first come up with a diagonal coding scheme (DCS) by distributing the updating dependencies evenly among devices to improve the system-level wear-leveling. DCS can efficiently improve the array endurance if requests are aligned with the stripe size, i.e., when data symbols in the same stripe receive the same number of writes, while the number could be different for different stripes. To relax the above assumption, we further propose an enhanced scheme, DCS+. With a buffer design, DCS+ can improve the wear-leveling among devices under general access patterns via triggering different responses to different kinds of requests. We conduct extensive trace-driven evaluations based on real-world workloads, and results show that our design efficiently enhances the endurance of SSD-based RAID arrays.",
        "keywords": [
            "Arrays",
            "Encoding",
            "Reed-Solomon codes",
            "Redundancy",
            "Organizations",
            "Complexity theory"
        ],
        "authors": [
            {
                "name": "Yubiao Pan",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Biaobiao Shen",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            }
        ],
        "venue": "IEEE Trans. on CAD of Integrated Circuits and Systems",
        "year": 2016
    },
    "XpdCvy8p": {
        "id": "XpdCvy8p",
        "title": "ISM- An Intra-Stripe Data Migration Approach for RAID-5 Scaling.",
        "abstract": "Scaling is often carried out in modern RAID systems to meet the ever increasing demand of storage capacity and I/O performance. However, the scaling process of RAID-5 system is not trivial, due to its specific data/parity layout. Previous approaches of RAID-5 scaling require either migrating almost all data blocks in the system, or recalculating all or some of the parity blocks during scaling. This paper proposes a new RAID-5 scaling approach called ISM (Intra-Stripe Migration). With ISM, data migrations only happen within stripes, which means that the coding relationship among blocks remains the same. Therefore, the parity blocks do not need to be recalculated after data migration, which greatly reduces the I/O and computational costs. The properties of ISM approach can be summarized as follows: (1) it requires the minimum amount of data blocks to be migrated, (2) it supports data migration without recalculating parity blocks, and (3) it supports multiple successive scaling operations while keeping the above properties. The simulation results on DiskSim show that: (1) ISM reduces the scaling time from 47.91% to 87.01% and from 88.94% to 96.58% compared with GSR and ALV respectively in offline scaling, (2) under two real-world I/O traces, ISM also outperforms GSR by 64.15% to 87.30%, and ALV by 92.38% to 95.98% in scaling time, and (3) ISM maintains almost the same performance of data access with ALV and GSR after scaling.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Liang",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yubiao Pan",
                "org": "University of Science and Technology of China"
            }
        ],
        "venue": "NAS",
        "year": 2017
    },
    "1ERLyMzz": {
        "id": "1ERLyMzz",
        "title": "Stochastic analysis of a randomized detection algorithm for pollution attack in P2P live streaming systems",
        "abstract": "Pollution attack is known to have a disastrous effect on existing P2P infrastructures: it can reduce the number of legitimate P2P users by as much as 85%, and it generates abundant bogus data which may deplete the communication bandwidth. We propose a distributed defense and detection mechanism to resolve pollution attacks. The mechanism is composed of a set of ''randomized'' and ''fully distributed'' algorithms that can be executed by any legitimate peer. We present the analytical framework to quantify (a) the probability of false negative, (b) the probability of false positive, and (c) the distribution of time needed for detection. In our detection algorithm and analysis, we consider the case of (1) single attacker within the neighborhood, (2) multiple attackers within the neighborhood. Furthermore, we show how to ''optimize'' the system parameters so as to quickly discover and eliminate malicious peers from the system.",
        "keywords": [
            "p2p infrastructure",
            "system parameter",
            "communication bandwidth",
            "abundant bogus data",
            "detection mechanism",
            "disastrous effect",
            "p2p user",
            "security",
            "p2p",
            "analytical framework",
            "randomized detection algorithm",
            "pollution attack",
            "stochastic analysis",
            "detection algorithm",
            "distributed algorithm",
            "false positive"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "John C. S. Lui",
                "org": "Department of Computer Science and Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong"
            }
        ],
        "venue": "Perform. Eval.",
        "year": 2010
    },
    "Z5g8xlzB": {
        "id": "Z5g8xlzB",
        "title": "Deterministic Data Distribution for Efficient Recovery in Erasure-Coded\n  Storage Systems",
        "abstract": "Due to individual unreliable commodity components, failures are common in large-scale distributed storage systems. Erasure codes are widely deployed in practical storage systems to provide fault tolerance with low storage overhead. However, random data distribution (RDD), commonly used in erasure-coded storage systems, induces heavy cross-rack traffic, load imbalance, and random access, which adve...",
        "keywords": [
            "Arrays",
            "Bandwidth",
            "Maintenance engineering",
            "Layout",
            "Fault tolerance",
            "Fault tolerant systems"
        ],
        "authors": [
            {
                "name": "Xu Liangliang",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Lyu Min",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Li Zhipeng",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Li Yongkun",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Xu Yinlong",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            }
        ],
        "venue": "IEEE Transactions on Parallel and Distributed Systems",
        "year": 2020
    },
    "22vfGJ81": {
        "id": "22vfGJ81",
        "title": "HP-Mapper - A High Performance Storage Driver for Docker Containers.",
        "abstract": "Docker containers are widely deployed to provide lightweight virtualization, and they have many desirable features such as ease of deployment and near bare-metal performance. However, both the performance and cache efficiency of containers are still limited by their storage drivers due to the coarse-grained copy-on-write operations, and the large amount of redundancy in both I/O requests and page cache. To improve I/O performance and cache efficiency of containers, we develop HP-Mapper, a high performance storage driver for Docker containers. HP-Mapper provides a two-level mapping strategy to support fine-grained copy-on-write with low overhead, and an efficient interception method to reduce redundant I/Os. Furthermore, it uses a novel cache management mechanism to reduce duplicate cached data. Experiment results with our prototype system show that HP-Mapper significantly reduces copy-on-write latency due to its finer-grained copy-on-write scheme. Moreover, HP-Mapper can also reduce 65.4% cache usage on average due to elimination of duplicated data. As a result, HP-Mapper improves the throughput of real-world workloads by up to 39.4%, and improves the startup speed of containers by 2.0x.\n\n",
        "keywords": "",
        "authors": [
            {
                "name": "Fan Guo",
                "org": "University of Sci. and Tech. of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Sci. and Tech. of China"
            },
            {
                "name": "Min Lv",
                "org": "University of Sci. and Tech. of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Sci. and Tech. of China"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong"
            }
        ],
        "venue": "SoCC '19: ACM Symposium on Cloud Computing\n\t\t      Santa Cruz\n\t\t      CA\n\t\t      USA\n\t\t    November, 2019",
        "year": 2019
    },
    "Hx39jPka": {
        "id": "Hx39jPka",
        "title": "LCR: Load-Aware Cache Replacement Algorithm for Flash-Based SSDs.",
        "abstract": "Flash-based SSDs are usually equipped with an onboard cache to further improve system performance by smoothing the gap between the upper-level applications and lower-level flash chips. Since modern SSDs are usually composed of multiple flash chips, and the load of flash chips are significantly different, it is very meaningful to be aware of the chip load condition when designing a cache replacement algorithm. Nevertheless, existing cache replacement algorithms only consider to reduce the cache miss ratio so as to reduce the I/O requests to the underlying flash memory as much as possible, none of them considers the load condition of flash chips. In this paper, we propose a Load- aware Cache Replacement algorithm, called LCR, to improve the performance of flash-based SSDs. The basic idea is to give a higher priority to cache the blocks on overloaded flash chips. We evaluate the performance of our scheme by using a trace- driven simulator with multiple real-world workloads, and results show that compared with the most common algorithm LRU and the state-of-the-art algorithm GCaR, LCR reduces the average response time by as much as 39.2% and 12.3%, respectively.",
        "keywords": "",
        "authors": [
            {
                "name": "Caiyin Liu",
                "org": ""
            },
            {
                "name": "Min Lv",
                "org": ""
            },
            {
                "name": "Yubiao Pan",
                "org": ""
            },
            {
                "name": "Hao Chen",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Cheng Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "NAS",
        "year": 2018
    },
    "hXetUKe7": {
        "id": "hXetUKe7",
        "title": "ElasticBF - Elastic Bloom Filter with Hotness Awareness for Boosting Read Performance in Large Key-Value Stores.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Univ of Science and Technology of China"
            },
            {
                "name": "Chengjin Tian",
                "org": "Univ of Science and Technology of China"
            },
            {
                "name": "Fan Guo",
                "org": "Univ of Science and Technology of China"
            },
            {
                "name": "Cheng Li",
                "org": "Univ of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "Univ of Science and Technology of China"
            }
        ],
        "venue": "USENIX Annual Technical Conference",
        "year": 2019
    },
    "U8jIDAY5": {
        "id": "U8jIDAY5",
        "title": "Popularity-based Online Scaling for RAID Systems under General Settings",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chengjin Tian",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Si Wu",
                "org": ""
            },
            {
                "name": "Jinzhong Chen",
                "org": ""
            },
            {
                "name": "Liu Yuan",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems",
        "year": 2019
    },
    "RJOMfRL7": {
        "id": "RJOMfRL7",
        "title": "Impact of Data Locality on Garbage Collection in SSDs: A General Analytical Study",
        "abstract": "Solid-state drives (SSDs) necessitate garbage collection (GC) to erase data blocks and reclaim the space of invalidated data, and GC inevitably introduces additional writes due to data relocation. The performance of GC, which is quantified by cleaning cost or write amplification, is critical to the overall performance of SSDs. However, characterizing GC performance is complicated by the general implementations of GC algorithms and the complex data locality characteristics of real-world workloads. This paper presents a general analytical study to characterize the performance impact of data locality on a general family of GC algorithms. We develop probabilistic models to address two fundamental issues: (1) What is the impact of data locality on the performance of locality-oblivious GC? (2) How can data locality be leveraged to improve the performance in locality-aware GC? We further conduct extensive trace-driven simulations on real-world workloads to validate the findings of our models.",
        "keywords": [
            "ssds",
            "performance analysis and design aids",
            "data locality",
            "garbage collection",
            "probabilistic algorithms",
            "trade-off",
            "trade off"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Patrick P. C. Lee",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "ICPE",
        "year": 2015
    },
    "MSnHtkTm": {
        "id": "MSnHtkTm",
        "title": "OI-RAID: A Two-Layer RAID Architecture towards Fast Recovery and High Reliability.",
        "abstract": "A lot of inexpensive disks in modern storage systems induce frequent disk failures. It takes a long time to recover a failed disk due to its large capacity and limited I/O. This paper proposes a hierarchical architecture of erasure code, OI-RAID. OI-RAID consists of two layers of codes, outer layer code and inner layer code. The outer layer code is based on disk grouping and Balanced Incomplete Block Design (BIBD) with skewed data layout to provide efficient parallel I/O of all disks for failure recovery. Inner layer code is deployed within a group of disks. As an example, we deploy RAID5 in both layers and present detailed performance analysis. With RAID5 in both layers, OI-RAID tolerates at least three disk failures meeting practical data availability, and achieves much higher speed up of disk failure recovery than existing approaches, while keeping optimal data update complexity and practically low storage overhead.",
        "keywords": "",
        "authors": [
            {
                "name": "Neng Wang",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Si Wu",
                "org": ""
            }
        ],
        "venue": "DSN",
        "year": 2016
    },
    "UxR2rjxc": {
        "id": "UxR2rjxc",
        "title": "FlameDB: A Key-Value Store With Grouped Level Structure and Heterogeneous Bloom Filter.",
        "abstract": "Key-value (KV) stores are widely used to provide much higher read and write throughput than traditional SQL databases. In particular, LSM-tree based KV store is popular with many applications since it could eliminate random writes and thus provides good write performance. However, the data residing in external storage are compacted from time to time, which takes a large amount of I/O resources and degrades the system performance. In this paper, we propose FlameDB, which leverages grouped level structure (GLS) to mitigate the compaction overhead. Besides dividing the whole storage space into multiple components as in LSM-tree, GLS further divides each component into multiple groups and compacts all KV items in a component as a group of the next component. Besides, we also propose a heterogeneous bloom filter (HEBF) scheme which assigns more bits to the bloom filters in upper components. With HEBF, the false positive rate of a bloom filter in upper components become smaller, and this scheme reduces the expected number of I/Os to read a KV item from the external storage with a given memory usage. Our experiments show that FlameDB saves about 75% I/O during compaction, so it improves the write throughput by about four times. Meanwhile, the read performance is also slightly improved by deploying HEBF.",
        "keywords": "",
        "authors": [
            {
                "name": "Weitao Zhang",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "Anhui Province Key Laboratory of High Performance Computing, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yueming Zhang",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Dinglong Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            }
        ],
        "venue": "IEEE Access",
        "year": 2018
    },
    "g4uQBaCM": {
        "id": "g4uQBaCM",
        "title": "Grouping-Based Elastic Striping with Hotness Awareness for Improving SSD RAID Performance",
        "abstract": "RAID provides a good option to provide device-level fault tolerance. Conventional RAID usually updates parities with read-modify-write or read-reconstruct-write, which may introduce a lot of extra I/Os and thus significantly degrade SSD RAID performance. The recently proposed elastic striping scheme reconstructs new stripes with updated new data chunks without updating old parity chunks. However, it necessitates RAID-level garbage collection which may incur a very high cost. In this paper, we propose a hotness-aware caching scheme to buffer incoming writes and categorize data chunks in buffers into multiple groups according to their hotness values. We then propose a grouping-based elastic striping scheme to separately write data chunks in different groups into SSDs. We deployed the proposed schemes on a RAID-5 array composed of eight commercial SSDs, and experimental results show that compared to elastic striping, our scheme reduces 26% -- 65% of chunk writes to SSDs, and also reduces the average response time by 17.2% -- 63.9%.",
        "keywords": [],
        "authors": [
            {
                "name": "Yubiao Pan",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            },
            {
                "name": "Zhipeng Li",
                "org": ""
            }
        ],
        "venue": "The International Conference on Dependable Systems and Networks",
        "year": 2015
    },
    "chFzSYhG": {
        "id": "chFzSYhG",
        "title": "Efficient Parity Update for Scaling RAID-like Storage Systems.",
        "abstract": "It is inevitable to scale RAID systems with the increasing demand of storage capacity and I/O throughput. When scaling RAID systems, we will always need to update parity to maintain the reliability of the storage systems. There are two schemes, read-modify-write (RMW) and read-reconstruct-write (RCW), to update parity. However most existing scaling approaches simply use RMW to update parity. While in many scenarios for existing scaling approaches, RCW performs better in terms of the number of scaling I/Os. In this paper, we propose an algorithm, called EPU, to analyze which of RCW and RMW is better for a scaling scenario and select the more efficient one to save the scaling I/Os. We apply EPU to online scaling scenarios and further use two optimizations, I/O overlap and access aggregation, to enhance the online scaling performance. Using Scale-CRS, one of the existing scaling approaches, as an example, we show via numerical studies that Scale-CRS+EPU reduces the amount of scaling I/Os over the traditional Scale-CRS in many scaling cases. To justify the online efficiency of EPU, we implement both Scale-CRS+EPU and Scale-CRS in a simulator with Disksim as a working module. Through extensive experiments, we show that Scale-CRS+EPU reduces the scaling time and the online response time of user requests over Scale-CRS.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongdong Sun",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Si Wu",
                "org": ""
            },
            {
                "name": "Chengjin Tian",
                "org": ""
            }
        ],
        "venue": "NAS",
        "year": 2016
    },
    "Ix2U58EE": {
        "id": "Ix2U58EE",
        "title": "Analysis of Reliability Dynamics of SSD RAID.",
        "abstract": "Solid-state drives (SSDs) have been widely deployed in desktops and data centers. However, SSDs suffer from bit errors, and the bit error rate is time dependent since it increases as an SSD wears down. Traditional storage systems mainly use parity-based RAID to provide reliability guarantees by striping redundancy across multiple devices, but the effectiveness of traditional RAID schemes in SSDs remains debatable. In particular, an open problem is how different parity distributions over multiple devices influence the reliability of an SSD RAID array. That is, should we evenly distribute patsaverties as suggested by conventional wisdom, or unevenly distribute parties as recently proposed for SSD RAID? To address this fundamental problem, we propose the first analytical model to quantify the reliability dynamics of an SSD RAID array as it ages. Specifically, we develop a “non-homogeneous” continuous time Markov chain model, and derive the transient reliability solution. We validate our model via trace-driven simulation and conduct numerical analysis to analyze the reliability dynamics of SSD RAID arrays subject to different parity distributions, error rates, and SSD array configurations. Our model enables system practitioners to decide the appropriate parity distribution based on their reliability requirements.",
        "keywords": [
            "Arrays",
            "Reliability",
            "Error analysis",
            "Ash",
            "Numerical models",
            "Transient analysis",
            "Aging"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "Department of Computer Science and Engineering, Chinese University of Hong Kong, Shatin, Hong Kong"
            },
            {
                "name": "John C. S. Lui",
                "org": "Department of Computer Science and Engineering, Chinese University of Hong Kong, Shatin, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. Computers",
        "year": 2016
    },
    "D1uejBiP": {
        "id": "D1uejBiP",
        "title": "Friends or Foes: Distributed and Randomized Algorithms to Determine Dishonest Recommenders in Online Social Networks",
        "abstract": "Viral marketing is becoming important due to the popularity of online social networks (OSNs). Companies may provide incentives (e.g., via free samples of a product) to a small group of users in an OSN, and these users provide recommendations to their friends, which eventually increases the overall sales of a given product. Nevertheless, this also opens a door for malicious behaviors: dishonest users may intentionally give misleading recommendations to their friends so as to distort the normal sales distribution. In this paper, we propose a detection framework to identify dishonest users in the OSNs. In particular, we present a set of fully distributed and randomized algorithms, and also quantify the performance of the algorithms by deriving probability of false positive, probability of false negative, and the distribution of number of detection rounds. Extensive simulations are also carried out to illustrate the impact of misleading recommendations and the effectiveness of our detection algorithms. The methodology we present here will enhance the security level of viral marketing in the OSNs.",
        "keywords": [
            "distributed algorithms",
            "false positive probability",
            "detection framework",
            "false negative probability",
            "randomized algorithm",
            "malicious behaviors",
            "distributed algorithm",
            "dishonest recommender determination",
            "osn",
            "randomised algorithms",
            "recommender systems",
            "number-of-detection rounds distribution",
            "marketing data processing",
            "behavioural sciences computing",
            "online social networks",
            "misbehavior detection",
            "viral marketing",
            "social networking (online)",
            "dishonest recommenders",
            "security of data",
            "probability"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Information Forensics and Security",
        "year": 2014
    },
    "39JbkHn0": {
        "id": "39JbkHn0",
        "title": "Impact of Online Activities on Influence Maximization: A Random Walk Approach.",
        "abstract": "With the popularity of OSNs, finding a set of most influential users so as to trigger the largest influence cascade is of significance. This task is usually modeled as an influence maximization problem, and it has been widely studied in the past decade. However, considering that users in OSNs may participate in various kinds of online activities, e.g., giving ratings to products, joining discussion groups, etc., influence diffusion through online activities becomes even more significant. Thus, it necessitates to revisit the influence maximization problem by taking online activities into consideration. In this paper, we study the impact of online activities by formulating the influence maximization problem for social-activity networks (SANs) containing both users and online activities. To address the computation challenge, we define an influence centrality via random walks on hypergraph to measure influence, then use the Monte Carlo framework to efficiently estimate the centrality in SANs, and use the Hoeffding inequality to bound the approximation error. Furthermore, we develop a greedy-based algorithm with two novel optimization techniques to find the most influential users. By conducting extensive experiments with real-world datasets, we show that compared to the state-of-the-art algorithm IMM [20], our approach improves the accuracy of selecting the top k most influential users in SANs by up to an order of magnitude, and our approach has a comparable computation time even though it needs to handle a large amount of online activities. Furthermore, our approach is also general enough to work under different diffusion models, e.g., IC and LT models, as well as heterogeneous systems, e.g., multiple types of users and online activities in SANs.",
        "keywords": [],
        "authors": [
            {
                "name": "Pengpeng Zhao",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Hong Xie",
                "org": ""
            },
            {
                "name": "Zhiyong Wu",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            },
            {
                "name": "Richard T. B. Ma",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "arXiv: Social and Information Networks",
        "year": 2016
    },
    "5ccy3ox3": {
        "id": "5ccy3ox3",
        "title": "A General Framework for Estimating Graphlet Statistics via Random Walk.",
        "abstract": "Graphlets are induced subgraph patterns and have been frequently applied to characterize the local topology structures of graphs across various domains, e.g., online social networks (OSNs) and biological networks. Discovering and computing graphlet statistics are highly challenging. First, the massive size of real-world graphs makes the exact computation of graphlets extremely expensive. Secondly, the graph topology may not be readily available so one has to resort to web crawling using the available application programming interfaces (APIs). In this work, we propose a general and novel framework to estimate graphlet statistics of \\\"any size.\\\" Our framework is based on collecting samples through consecutive steps of random walks. We derive an analytical bound on the sample size (via the Chernoff-Hoeffding technique) to guarantee the convergence of our unbiased estimator. To further improve the accuracy, we introduce two novel optimization techniques to reduce the lower bound on the sample size. Experimental evaluations demonstrate that our methods outperform the state-of-the-art method up to an order of magnitude both in terms of accuracy and time cost.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiaowei Chen",
                "org": "The Chinese University of Hong Kong"
            },
            {
                "name": "Yongkun Li",
                "org": "Univ of Science and Technology of China"
            },
            {
                "name": "Pinghui Wang",
                "org": "Xi ’an Jiaotong University"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong"
            }
        ],
        "venue": "PVLDB",
        "year": 2016
    },
    "6t8Y4483": {
        "id": "6t8Y4483",
        "title": "Friends or Foes: Detecting Dishonest Recommenders in Online Social Networks",
        "abstract": "Viral marketing is becoming important due to the popularity of online social networks (OSNs) and the fact that many users have integrated OSNs into their daily activities, e.g., they provide recommendations to their friends on the products they purchased, or they make decision based on received recommendations. Nevertheless, this also opens door for \"shill attack\": dishonest users may give wrong recommendations so as to distort the normal sales distribution. In this paper, we propose a detection mechanism to discover these dishonest users in OSNs. In particular, we present two fully distributed algorithms to detect attackers in both (1) the baseline shill attack and (2) the intelligent shill attack. We quantify the performance of our algorithms by deriving the probability of false positive, probability of false negative and distribution function of time needed to detect these dishonest users. Extensive simulations are carried to illustrate the impact of shill attack and the effectiveness of our detection algorithms. The methodology we present here will enhance the security level of viral marketing in OSNs.",
        "keywords": [
            "distributed algorithms",
            "false positive probability",
            "false negative probability",
            "normal sales distribution",
            "distribution function",
            "dishonest recommender detection",
            "baseline shill attack",
            "intelligent shill attack",
            "marketing data processing",
            "online social networks",
            "viral marketing",
            "social networking (online)",
            "security of data",
            "probability",
            "computer model",
            "distributed algorithm",
            "nickel",
            "indexing terms",
            "false positive",
            "computational modeling",
            "history",
            "detectors"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "ICCCN",
        "year": 2011
    },
    "10iECJyc": {
        "id": "10iECJyc",
        "title": "Explicit Data Correlations-Directed Metadata Prefetching Method in Distributed File Systems",
        "abstract": "Metadata performance in distributed file systems (DFS) is critical, due to the following trends: (a) the growing size of modern storage systems is expected to exceed billions of files and most files are small; (b) over half of the file accesses are metadata operations. In this work, we present SMeta, a metadata prefetching method that is seamlessly integrated into DFS for easy-of-use and significantly scales the metadata performance. Previous prefetching proposals primarily focus on mining groups of files that tend to be accessed together from the access history. Nevertheless, our study discovered that these solutions likely miss a huge number of correlated files whose co-occurrence frequency is not high enough. Unlike access correlations, we take a novel and completely different approach to explore explicit data correlations by understanding the reference relationships between files encoded in some forms of hyperlinks, which naturally exist in many applications. To embrace this new concept, SMeta explores correlations upon files are written via a light-weight pattern matching algorithm, stores correlations in the reserved extended attributes of file metadata to avoid changes in DFS APIs, and collapses multiple I/O rounds for accessing metadata of the target file and its data-correlated files into one round. A cost-efficient adaptive feedback mechanism is introduced to improve prefetching accuracy. We implemented SMeta atop of Ceph and evaluated it using synthetic and real system workloads. Compared to baselines, SMeta provides better metadata performance in terms of latency, throughput and scalability.",
        "keywords": [
            "Correlation",
            "Metadata",
            "Prefetching",
            "Linux",
            "Kernel",
            "Data mining",
            "Servers"
        ],
        "authors": [
            {
                "name": "Youxu Chen",
                "org": "Department of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Cheng Li",
                "org": "Department of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Min Lv",
                "org": "Department of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Xinyang Shao",
                "org": "Department of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "Department of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            }
        ],
        "venue": "IEEE Transactions on Parallel and Distributed Systems",
        "year": 2019
    },
    "zqv6Fh44": {
        "id": "zqv6Fh44",
        "title": "DSC: Dynamic stripe construction for asynchronous encoding in clustered file system.",
        "abstract": "Nowadays many clustered file systems adopt asynchronous encoding which transforms replicated data into erasure coding to maintain data availability with bounded storage overhead. Existing implementations of asynchronous encoding construct coding stripes with logically sequential data blocks, which suffers from heavy cross-rack traffic and necessitates data block redistribution. Recent work [12] solves this problem by carefully distributing replicated data blocks among racks at the time when they are being written, but it is not applicable to the cases when existing systems have different data layouts or the data layout changes. In this paper, we propose Dynamic Stripe Construction (DSC) to transform N-way replication to erasure coding. DSC does not induce to any cross-rack traffic for encoding, and it does not require data block redistribution after encoding. Besides, DSC is general enough to be applied to any existing CFSes with various erasure codes, and it can also be deployed on a distributed file system in a hot-plugging-in manner. To validate the effectiveness of DSC, we implement it on HDFS. Through extensive testbed experiments in a real storage cluster, we show that DSC can significantly increase the encoding throughput and reduce the foreground user response time over the traditional approach.",
        "keywords": "",
        "authors": [
            {
                "name": "Shuzhan Wei",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            },
            {
                "name": "Si Wu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            }
        ],
        "venue": "INFOCOM",
        "year": 2017
    },
    "0OhGYpmw": {
        "id": "0OhGYpmw",
        "title": "Modeling SSD RAID reliability under general settings.",
        "abstract": "Solid-state drives (SSDs) are susceptible to the limited number of program/erase (P/E) cycles and uncorrectable flash errors, and hence achieving high reliability of SSD storage systems is a critical issue. RAID provides a viable option for enhancing system reliability by distributing redundancy across a number of SSDs. However, the flash error rate of an SSD increases with the number of P/E cycles, and this time-varying nature complicates the reliability analysis of SSD RAID. In addition, there remains very limited formal analysis that quantifies the reliability dynamics of an SSD RAID array under general settings. To this end, we propose a new continuous time Markov chain (CTMC) model to characterize the reliability dynamics of SSD RAID over time under two general settings: (1) fault tolerance against a general number of device failures and (2) non-uniform workload. We validate the correctness of our CTMC model via trace-driven simulations. Based on our model, we further analyze the impact of different RAID parameters on the reliability dynamics of an SSD RAID array.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhiyong Wu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "The Chinese University of Hong Kong"
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "CF",
        "year": 2018
    },
    "Gpf7T3bx": {
        "id": "Gpf7T3bx",
        "title": "Fast graph centrality computation via sampling: a case study of influence maximisation over OSNs.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Wang",
                "org": ""
            },
            {
                "name": "Min Lv",
                "org": ""
            },
            {
                "name": "Zhiyong Wu",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "IJHPCN",
        "year": 2019
    },
    "9ofhYtQm": {
        "id": "9ofhYtQm",
        "title": "Enabling Efficient Updates in KV Storage via Hashing: Design and Performance Evaluation",
        "abstract": "Persistent key-value (KV) stores mostly build on the Log-Structured Merge (LSM) tree for high write performance, yet the LSM-tree suffers from the inherently high I/O amplification. KV separation mitigates I/O amplification by storing only keys in the LSM-tree and values in separate storage. However, the current KV separation design remains inefficient under update-intensive workloads due to its high garbage collection (GC) overhead in value storage. We propose HashKV, which aims for high update performance atop KV separation under update-intensive workloads. HashKV uses hash-based data grouping, which deterministically maps values to storage space so as to make both updates and GC efficient. We further relax the restriction of such deterministic mappings via simple but useful design extensions. We extensively evaluate various design aspects of HashKV. We show that HashKV achieves 4.6x update throughput and 53.4% less write traffic compared to the current KV separation design. In addition, we demonstrate that we can integrate the design of HashKV with state-of-the-art KV stores and improve their respective performance.",
        "keywords": [
            "Hashing",
            "Key-value storage",
            "LSM-tree"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Helen H. W. Chan",
                "org": "The Chinese University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "The Chinese University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China, Hefei, Anhui, China"
            }
        ],
        "venue": "ACM Transactions on Storage",
        "year": 2019
    },
    "8Rx5zHh1": {
        "id": "8Rx5zHh1",
        "title": "Lifetime-aware FTL to improve the lifetime and performance of solid-state drives.",
        "abstract": "Data compression techniques have been deployed in SSDs to prolong their lifetime due to the good tradeoff between data reduction and performance degradation. However, existing schemes either consume plenty of DRAM resources, or cause the read amplification problem, which may further result in significant performance degradation. In this paper, we propose a lifetime-aware FTL scheme (LAFTL) to improve both the lifetime and performance of SSDs by compressing several pages into one physical page. We then design a compression-aware page mapping table (PMT) to reduce the memory consumption, and propose a latency-aware approach to improve the performance. We conduct extensive trace-driven evaluations based on real-world workloads, and results show that our LAFTL reduces the average response time of reads by 3%–78% and ensures a minimal resource consumption in DRAM while obtaining an acceptable data reduction rate compared to other schemes.",
        "keywords": [
            "Solid-state drives",
            "Lifetime-aware FTL",
            "Compression",
            "Endurance",
            "Performance"
        ],
        "authors": [
            {
                "name": "Yubiao Pan",
                "org": "The School of Computer Science and Technology, Huaqiao university, Xiamen, China"
            },
            {
                "name": "Yongkun Li",
                "org": "The School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Huizhen Zhang",
                "org": "The School of Computer Science and Technology, Huaqiao university, Xiamen, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "The School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            }
        ],
        "venue": "Future Generation Computer Systems",
        "year": 2019
    },
    "rMnCaAXN": {
        "id": "rMnCaAXN",
        "title": "Elastic Parity Logging for SSD RAID Arrays.",
        "abstract": "Parity-based RAID poses a design trade-off issue for large-scale SSD storage systems: it improves reliability against SSD failures through redundancy, yet its parity updates incur extra I/Os and garbage collection operations, thereby degrading the endurance and performance of SSDs. We propose EPLOG, a storage layer that reduces parity traffic to SSDs, so as to provide endurance, reliability, and performance guarantees for SSD RAID arrays. EPLOG mitigates parity update overhead via elastic parity logging, which redirects parity traffic to separate log devices (to improve endurance and reliability) and eliminates the need of pre-reading data in parity computations (to improve performance). We design EPLOG as a user-level implementation that is fully compatible with commodity hardware and general erasure coding schemes. We evaluate EPLOG through reliability analysis and trace-driven testbed experiments. Compared to the Linux software RAID implementation, our experimental results show that our EPLOG prototype reduces the total write traffic to SSDs, reduces the number of garbage collection operations, and increases the I/O throughput. In addition, EPLOG significantly improves the I/O performance over the original parity logging design, and incurs low metadata overhead.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Helen H. W. Chan",
                "org": ""
            },
            {
                "name": "Patrick P. C. Lee",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "DSN",
        "year": 2016
    },
    "yZtOsLxO": {
        "id": "yZtOsLxO",
        "title": "Stochastic modeling and optimization of garbage collection algorithms in solid-state drive systems",
        "abstract": "Markov chains and mean-field analysis are powerful tools and widely used for performance analysis in large-scale computer and communication systems. In this paper, we consider the application of Markov modeling and mean-field analysis to solid-state drives (SSDs). SSDs are now widely deployed in mobiles, desktops, and data centers due to their high I/O performance and low energy consumption. In particular, we focus on characterizing the performance---durability tradeoff of garbage collection (GC) algorithms in SSDs. Specifically, we first develop a stochastic Markov chain model to capture the I/O dynamics of large-scale SSDs, then adapt mean-field analysis to derive the asymptotic steady state, based on which we are able to easily analyze the performance---durability tradeoff of a large family of GC algorithms. We further prove the model convergence and generalize the model for all types of workload. Inspired by this model, we also propose a randomized greedy algorithm (RGA) which has a single tunable parameter to trade between performance and durability. Using trace-driven simulation on DiskSim with SSD add-ons, we demonstrate how RGA can be parameterized to realize the performance---durability tradeoff.",
        "keywords": [
            "Solid-state drives",
            "Garbage collection",
            "Wear-leveling",
            "Cleaning cost",
            "Markov model",
            "Mean-field analysis",
            "60H10",
            "60K30",
            "68M20"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Patrick P. C. Lee",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "Queueing Syst.",
        "year": 2014
    },
    "fQIns1Nk": {
        "id": "fQIns1Nk",
        "title": "HashKV: Enabling Efficient Updates in KV Storage via Hashing.",
        "abstract": "Persistent key-value (KV) stores mostly build on the Log-Structured Merge (LSM) tree for high write performance, yet the LSM-tree suffers from the inherently high I/O amplification. KV separation mitigates I/O amplification by storing only keys in the LSM-tree and values in separate storage. However, the current KV separation design remains inefficient under update-intensive workloads due to its high garbage collection (GC) overhead in value storage. We propose HashKV, which aims for high update performance atop KV separation under updateintensive workloads. HashKV uses hash-based data grouping, which deterministically maps values to storage space so as to make both updates and GC efficient. We further relax the restriction of such deterministic mappings via simple but useful design extensions. We compare HashKV with state-of-the-art KV stores via extensive testbed experiments, and show that HashKV achieves 4.6× throughput and 53.4% less write traffic compared to the current KV separation design.",
        "keywords": "",
        "authors": [
            {
                "name": "Helen H. W. Chan",
                "org": "The Chinese University of Hong Kong#TAB#"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China#TAB#"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "The Chinese University of Hong Kong#TAB#"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China#TAB#"
            }
        ],
        "venue": "USENIX Annual Technical Conference",
        "year": 2018
    },
    "GQP2GTWN": {
        "id": "GQP2GTWN",
        "title": "SSRW: A Scalable Algorithm for Estimating Graphlet Statistics Based on Random Walk.",
        "abstract": "Mining graphlet statistics is very meaningful due to its wide applications in social networks, bioinformatics and information security, etc. However, it is a big challenge to exactly count graphlet statistics as the number of subgraphs exponentially increases with the graph size, so sampling algorithms are widely used to estimate graphlet statistics within reasonable time. However, existing sampling algorithms are not scalable for large graphlets, e.g., they may get stuck when estimating graphlets with more than five nodes. To address this issue, we propose a highly scalable algorithm, Scalable subgraph Sampling via Random Walk (SSRW), for graphlet counts and concentrations. SSRW samples graphlets by generating new nodes from the neighbors of previously visited nodes instead of fixed ones. Thanks to this flexibility, we can generate any k-graphlets in a unified way and estimate statistics of k-graphlet efficiently even for large k. Our extensive experiments on estimating counts and concentrations of ({4,5,6,7})-graphlets show that SSRW algorithm is scalable, accurate and fast.",
        "keywords": "",
        "authors": [
            {
                "name": "Chen Yang",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Min Lyu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Qianqian Zhao",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            }
        ],
        "venue": "DASFAA",
        "year": 2018
    },
    "VJ3dSChc": {
        "id": "VJ3dSChc",
        "title": "GFTL: Group-Level Mapping in Flash Translation Layer to Provide Efficient Address Translation for NAND Flash-Based SSDs.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yubiao Pan",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Huizhen Zhang",
                "org": ""
            },
            {
                "name": "Hao Chen",
                "org": ""
            },
            {
                "name": "Mingwei Lin",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Consumer Electron.",
        "year": 2020
    },
    "r91SkHnn": {
        "id": "r91SkHnn",
        "title": "HCFTL - A Locality-Aware Page-Level Flash Translation Layer.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Chen",
                "org": ""
            },
            {
                "name": "Cheng Li",
                "org": ""
            },
            {
                "name": "Yubiao Pan",
                "org": ""
            },
            {
                "name": "Min Lyu",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "DATE",
        "year": 2019
    },
    "Sp5baRLQ": {
        "id": "Sp5baRLQ",
        "title": "A Light-Weight Hot Data Identification Scheme via Grouping-based LRU Lists.",
        "abstract": "Real-world workloads generally exhibit high skewness in access patterns, and it is a consensus that separating hot and cold data may greatly improve storage system performance such as Solid State Drive(SSD) garbage collection(GC) performance. To achieve this, the key issue is how to accurately identify hot data, which is really challenging due to the large diversity and dynamics of workloads. In this paper, we propose a light-weight and high-accuracy identification scheme, which is developed via a group of Least Recently Used (LRU) lists and requires only a small amount of memory and CPU cycles. We further deploy our scheme on SSDs with DiskSim simulator, and results show that comparing to two state-of-the-art identification schemes, our scheme further reduces SSD GC cost by up to 59.1 % (62.1 %), and saves 44.3 % (77.5 %) of computational cost. Due to the light-weight and parameter-insensitive feature, our scheme can be easily deployed at various system levels and adaptable to different workloads.",
        "keywords": [],
        "authors": [
            {
                "name": "Biaobiao Shen",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            },
            {
                "name": "Yubiao Pan",
                "org": ""
            }
        ],
        "venue": "ICA3PP",
        "year": 2015
    },
    "Z3QNgM46": {
        "id": "Z3QNgM46",
        "title": "Elastic Parity Logging for SSD RAID Arrays: Design, Analysis, and Implementation.",
        "abstract": "Parity-based RAID poses a design trade-off issue for large-scale SSD storage systems: it improves reliability against SSD failures through redundancy, yet its parity updates incur extra I/Os and garbage collection operations, thereby degrading the endurance and performance of SSDs. We propose EPLOG, a storage layer that reduces parity traffic to SSDs, so as to provide endurance, reliability, and p...",
        "keywords": [
            "Performance evaluation",
            "Arrays",
            "Prototypes",
            "Reliability engineering",
            "Encoding",
            "Software"
        ],
        "authors": [
            {
                "name": "Helen H. W. Chan",
                "org": "Department of Computer Science and Engineering, Chinese University of Hong Kong, Sha Tin, Hong Kong"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei Shi, Anhui Sheng, China"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "Department of Computer Science and Engineering, Chinese University of Hong Kong, Sha Tin, Hong Kong"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei Shi, Anhui Sheng, China"
            }
        ],
        "venue": "IEEE Transactions on Parallel and Distributed Systems",
        "year": 2018
    },
    "pZ1AsQqF": {
        "id": "pZ1AsQqF",
        "title": "PDS: An I/O-Efficient Scaling Scheme for Parity Declustered Data Layout.",
        "abstract": "Parity declustering is widely deployed in erasure coded storage systems so as to provide fast recovery and high data availability. However, to perform scaling on such RAIDs, it is necessary to preserve the parity declustered data layout so as to guarantee the RAID performance after scaling. Unfortunately, existing scaling algorithms fail to achieve this goal so they can not be applied for scaling RAIDs which have deployed parity declustering. To address this challenge, we develop an efficient scaling algorithm called PDS (Parity Declustering Scaling). In particular, we first employ an auxiliary Balanced Incomplete Block Design (BIBD) to define the data migrations during scaling so as to preserve parity declustered data layout, and then define the addressing algorithm in the scaled system based on the migrations. We provide theoretical proofs to show that PDS preserves the parity declustered data layout, which is the basis for scaling RAIDs with parity declustering, and also theoretically prove that PDS achieves the even distribution of data/parity blocks after scaling and requires only the minimal data migrations. To show the performance of PDS, we implement it in MD in Linux Kernel, and conduct experiments with real-world traces. Results show PDS can reduce 89.70% of data migration time and 24.44% of user response time during scaling on average, compared with the round-robin scheme.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhipeng Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Chengjin Tian",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Youhui Bai",
                "org": ""
            }
        ],
        "venue": "ICPP",
        "year": 2017
    },
    "FaX1QEeQ": {
        "id": "FaX1QEeQ",
        "title": "A Fast Approach to Scale Up Disk Arrays With Parity Declustered Data Layout by Minimizing Data Migration.",
        "abstract": "Parity declustering is widely deployed in erasure-coded storage systems so as to provide fast recovery and high data availability. However, to perform scaling on such redundant array of inexpensive disks (RAIDs), it is necessary to preserve parity declustered data layout so as to preserve the properties after scaling. Unfortunately, existing scaling algorithms fail to achieve this goal so they cannot be applied for scaling RAIDs with parity declustering. To address this challenge, we develop an efficient online scaling scheme called parity declustering scaling (PDS), which employs an auxiliary balanced incomplete block design to define the data migration so as to preserve parity declustered data layout. Furthermore, PDS can also be applied to scale RAIDs for improving reliability and/or storage efficiency as options by allocating more parity blocks and/or data blocks in stripes. We provide theoretical proofs to formally show that PDS preserves parity declustered data layout, and achieves uniform distributions of data and parity blocks after scaling while requiring only the minimal data migration. We implement PDS in Linux kernel 3.14.72 and evaluate its performance with real-world traces. The results show that PDS can reduce 82.37 percent of scaling time and 18.25 percent of user response time during scaling on average, compared with “moving-everything” round-robin approach adapted to achieve parity declustered data layout after scaling.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhipeng Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Chengjin Tian",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "IEEE Access",
        "year": 2019
    },
    "xejTnMbs": {
        "id": "xejTnMbs",
        "title": "DCUDA - Dynamic GPU Scheduling with Live Migration Support.",
        "abstract": "In clouds and data centers, GPU servers which consist of multiple GPUs are widely deployed. Current state-of-the-art GPU scheduling algorithm are \"static\" in assigning applications to different GPUs. These algorithms usually ignore the dynamics of the GPU utilization and are often inaccurate in estimating resource demand before assigning/running applications, so there is a large opportunity to further load balance and to improve GPU utilization. Based on CUDA (Compute Unified Device Architecture), we develop a runtime system called DCUDA which supports \"dynamic\" scheduling of running applications between multiple GPUs. In particular, DCUDA provides a realtime and lightweight method to accurately monitor the resource demand of applications and GPU utilization. Furthermore, it provides a universal migration facility to migrate \"running applications\" between GPUs with negligible overhead. More importantly, DCUDA transparently supports all CUDA applications without changing their source codes. Experiments with our prototype system show that DCUDA can reduce 78.3% of overloaded time of GPUs on average. As a result, for different workloads consisting of a wide range applications we studied, DCUDA can reduce the average execution time of applications by up to 42.1%. Furthermore, DCUDA also reduces 13.3% energy in the light load scenario.\n\n",
        "keywords": "",
        "authors": [
            {
                "name": "Fan Guo",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            }
        ],
        "venue": "SoCC '19: ACM Symposium on Cloud Computing\n\t\t      Santa Cruz\n\t\t      CA\n\t\t      USA\n\t\t    November, 2019",
        "year": 2019
    },
    "bORUf4y6": {
        "id": "bORUf4y6",
        "title": "D3 - Deterministic Data Distribution for Efficient Data Reconstruction in Erasure-Coded Distributed Storage Systems.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": " Zhipeng Li",
                "org": "University of Science and Technology of China."
            },
            {
                "name": " Min Lv",
                "org": "University of Science and Technology of China."
            },
            {
                "name": " Yinlong Xu",
                "org": "University of Science and Technology of China."
            },
            {
                "name": " Yongkun Li",
                "org": "University of Science and Technology of China."
            },
            {
                "name": " Liangliang Xu",
                "org": "University of Science and Technology of China."
            }
        ],
        "venue": "IPDPS",
        "year": 2019
    },
    "aJ77K4Mm": {
        "id": "aJ77K4Mm",
        "title": "Leveraging Array Mapped Tries in KSM for Lightweight Memory Deduplication.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Lingjing You",
                "org": "University of Science and Technology of China."
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China."
            },
            {
                "name": "Fan Guo",
                "org": "University of Science and Technology of China."
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China."
            },
            {
                "name": "Jinzhong Chen",
                "org": "East China Research Institute of Electronic Engineering"
            },
            {
                "name": "Liu Yuan",
                "org": "China Academy of Electronics and Information Technology"
            }
        ],
        "venue": "NAS",
        "year": 2019
    },
    "kt2WXjmK": {
        "id": "kt2WXjmK",
        "title": "POS: A Popularity-based Online Scaling scheme for RAID-structured storage systems",
        "abstract": "The ever-increasing demand of storage capability leads to scaling requirement in RAID-structured storage systems. Previous approaches to RAID scaling mainly focus on minimizing data migration, without considering the user-level application accesses. However, the mixed scaling I/Os and user accesses in practical systems will interfere with each other, which results in significant performance degradation of both the data migration time and the user response time. In this paper, we divide the whole storage space into multiple zones and measure the popularity (mainly using the metric of access frequency) of each zone. Based on the measured popularity, we propose an online scheme, namely Popularity-based Online Scaling (POS), to scale RAID-structured storage systems. The main idea of POS is to scale storage areas with high popularity first so as to better exploit workload locality. POS can efficiently alleviate the performance degradation of user response time and data migration time during the scaling process. It can be readily deployed atop various conventional RAID scaling approaches to improve their performance. To evaluate the performance of POS, we implement FastScale and FastScale with POS (POS-FS) in the same system. Through extensive benchmark studies on real-system workloads, we show that POS can efficiently reduce the response time to user requests and scaling I/Os and improve the sequentiality of data accesses.",
        "keywords": [
            "benchmark testing",
            "bandwidth",
            "degradation"
        ],
        "authors": [
            {
                "name": "si wu",
                "org": "university of science and technology of china"
            },
            {
                "name": "yinlong xu",
                "org": "university of science and technology of china"
            },
            {
                "name": "yongkun li",
                "org": "university of science and technology of china"
            },
            {
                "name": "yunfeng zhu",
                "org": "university of science and technology of china"
            }
        ],
        "venue": "ICCD '15 Proceedings of the 2015 33rd IEEE International Conference on Computer Design (ICCD)",
        "year": 2015
    },
    "4kIKV2ID": {
        "id": "4kIKV2ID",
        "title": "On Modeling Product Advertisement in Large-Scale Online Social Networks",
        "abstract": "We consider the following advertisement problem in online social networks (OSNs). Given a fixed advertisement investment, e.g., a number of free samples that can be given away to a small number of users, a company needs to determine the probability that users in the OSN will eventually purchase the product. In this paper, we model OSNs as scale-free graphs (either with or without high clustering coefficient). We employ various influence mechanisms that govern the influence spreading in such large-scale OSNs and use the local mean field (LMF) technique to analyze these online social networks wherein states of nodes can be changed by various influence mechanisms. We extend our model for advertising with multiple rating levels. Extensive simulations are carried out to validate our models, which can provide insight on designing efficient advertising strategies in online social networks.",
        "keywords": [
            "Mathematical model",
            "Social network services",
            "Computational modeling",
            "Analytical models",
            "Random variables",
            "Approximation methods",
            "Equations"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong"
            },
            {
                "name": "Bridge Qiao Zhao",
                "org": "Department of Computer Science, Stanford University, Stanford, CA"
            },
            {
                "name": "John C. S. Lui",
                "org": "Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "IEEE/ACM Transactions on Networking (TON)",
        "year": 2012
    },
    "PAORF6zq": {
        "id": "PAORF6zq",
        "title": "Improving Write Performance of LSMT-Based Key-Value Store.",
        "abstract": "Key-value stores are widely used to provide much higher read and write throughput than traditional SQL databases. LSMT (log structure merge tree) based key-value store, as one type of key-value stores, is applied in many practical systems since it could eliminate random writes and provide good read performance at the same time. However, the data residing in disk needs compaction operations from time to time, which takes a large amount of I/O resources. Since disk access speed is much slower than DRAM and most data resides in disks, the compaction operation will significantly influence the system performance. In this paper, we propose a grouped level structure, which divides each level in LSMT into multiple groups. Also, we propose a new compaction method for the grouped level structure to reduce the compaction I/O overhead. Our experiments show that the grouped level structure saves about 55% to 78% I/O resource of compaction, so it improves the write throughput by 69% to 284%, but only reduces the read throughput by 5% to 9%. It improves the overall throughput by 30% to 69% with read dominated workloads of 25% write operations and 75% read operations.",
        "keywords": "",
        "authors": [
            {
                "name": "Weitao Zhang",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Dinglong Li",
                "org": "University of Science and Technology of China"
            }
        ],
        "venue": "ICPADS",
        "year": 2016
    },
    "toIVR7Zo": {
        "id": "toIVR7Zo",
        "title": "A Hierarchical RAID Architecture Towards Fast Recovery and High Reliability.",
        "abstract": "Disk failures are very common in modern storage systems due to the large number of inexpensive disks. As a result, it takes a long time to recover a failed disk due to its large capacity and limited I/O. To speed up the recovery process and maintain a high system reliability, we propose a hierarchical code architecture with erasure codes, OI-RAID, which consists of two layers of codes, outer layer...",
        "keywords": [
            "Layout",
            "Bandwidth",
            "Fault tolerant systems",
            "Redundancy",
            "Reed-Solomon codes"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Neng Wang",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Chengjin Tian",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Si Wu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Yueming Zhang",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, Anhui, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, AnHui Province Key Laboratory of High Performance Computing, University of Science and Technology of China, Hefei, Anhui, China"
            }
        ],
        "venue": "IEEE Transactions on Parallel and Distributed Systems",
        "year": 2018
    },
    "Hx0UAVHd": {
        "id": "Hx0UAVHd",
        "title": "ElasticBF: Fine-grained and Elastic Bloom Filter Towards Efficient Read for LSM-tree-based KV Stores.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yueming Zhang",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Fan Guo",
                "org": ""
            },
            {
                "name": "Cheng Li",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": ""
            }
        ],
        "venue": "HotStorage",
        "year": 2018
    },
    "4EeN2Or3": {
        "id": "4EeN2Or3",
        "title": "Epidemic Attacks in Network-Coding-Enabled Wireless Mesh Networks: Detection, Identification, and Evaluation",
        "abstract": "Epidemic attack is a severe security problem in network-coding-enabled wireless mesh networks (WMNs). Malicious nodes can easily launch such form of attack to create an epidemic spreading of polluted packets and deplete network resources. The contribution of this work is to address such security problem. We allow the presence of \"smartâ attackers, i.e., they can pretend to be legitimate nodes to probabilistically transmit valid packets so as to reduce the chance of being detected. We also address the case where attackers cooperatively inject polluted packets. We employ the time-based checksum and batch verification to determine the existence of polluted packets, then propose a set of fully \"distributedâ and \"randomizedâ detection algorithms so that each legitimate node in a WMN can identify its malicious neighbors and purge them for future communication. We provide formal analysis to quantify the performance of the algorithms. Furthermore, simulation and system prototyping are carried out to validate the theoretic analysis and show the effectiveness and efficiency of the detection algorithms.",
        "keywords": [
            "Detection algorithms",
            "Network coding",
            "Routing protocols",
            "Pollution",
            "Encoding",
            "Wireless mesh networks",
            "Throughput"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "The Chinese University of Hong Kong, Hong Kong"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. Mob. Comput.",
        "year": 2012
    },
    "olo8UBnn": {
        "id": "olo8UBnn",
        "title": "Stochastic Modeling of Hybrid Cache Systems.",
        "abstract": "  In recent years, there is an increasing demand of big memory systems so to perform large scale data analytics. Since DRAM memories are expensive, some researchers are suggesting to use other memory systems such as non-volatile memory (NVM) technology to build large-memory computing systems. However, whether the NVM technology can be a viable alternative (either economically and technically) to DRAM remains an open question. To answer this question, it is important to consider how to design a memory system from a \"system perspective\", that is, incorporating different performance characteristics and price ratios from hybrid memory devices.   This paper presents an analytical model of a \"hybrid page cache system\" so to understand the diverse design space and performance impact of a hybrid cache system. We consider (1) various architectural choices, (2) design strategies, and (3) configuration of different memory devices. Using this model, we provide guidelines on how to design hybrid page cache to reach a good trade-off between high system throughput (in I/O per sec or IOPS) and fast cache reactivity which is defined by the time to fill the cache. We also show how one can configure the DRAM capacity and NVM capacity under a fixed budget. We pick PCM as an example for NVM and conduct numerical analysis. Our analysis indicates that incorporating PCM in a page cache system significantly improves the system performance, and it also shows larger benefit to allocate more PCM in page cache in some cases. Besides, for the common setting of performance-price ratio of PCM, \"flat architecture\" offers as a better choice, but \"layered architecture\" outperforms if PCM write performance can be significantly improved in the future. ",
        "keywords": "",
        "authors": [
            {
                "name": "Gaoying Ju",
                "org": ""
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Jiqiang Chen",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong"
            }
        ],
        "venue": "MASCOTS",
        "year": 2016
    },
    "6pkzeUia": {
        "id": "6pkzeUia",
        "title": "GraphWalker - An I/O-Efficient and Resource-Friendly Graph Analytic System for Fast and Scalable Random Walks.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Wang",
                "org": "university of science and technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "university of science and technology of China"
            },
            {
                "name": "Hong Xie",
                "org": "Chongqing Univ.#TAB#"
            },
            {
                "name": "Yinlong Xu",
                "org": "university of science and technology of China"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong"
            }
        ],
        "venue": "USENIX Annual Technical Conference",
        "year": 2020
    },
    "vpaqDmZB": {
        "id": "vpaqDmZB",
        "title": "Balanced Parity Update Algorithm with Queueing Length Awareness for RAID Arrays.",
        "abstract": "In parity-based RAID arrays, to update a data chunk, the corresponding parity chunk(s) must be updated accordingly so as to keep data consistency and availability. To achieve this, either read-modify-write (RMW) or read-constructwrite (RCW) could be used. Traditional parity update algorithm always selects the one requiring fewer pre-reads so as to reduce the total number of I/Os, but it may aggravate the skewness of I/O queues on disks, and thus degrades the system performance. In this paper, we propose a balanced parity update algorithm with queueing length awareness, BPU, which takes the number of pre-reads, the skewness of I/O queues on disks, and realtime workload into consideration when selecting RCW or RMW to update parity chunks. We implement a prototype system with BPU to evaluate its performance. Experimental results show that the length of I/O queues on disks in a RAID array may be highly skewed when using traditional parity update algorithm, and thus severely degrades the system performance. With BPU, we can reduce the average response time by up to 10%. We also study the performance of BPU under different system configurations, and provide multiple insights for adjusting the parameters of BPU so as to optimize its performance.",
        "keywords": "",
        "authors": [
            {
                "name": "Youxu Chen",
                "org": ""
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Jun Xu",
                "org": ""
            }
        ],
        "venue": "ICPADS",
        "year": 2016
    },
    "LCCCtvPe": {
        "id": "LCCCtvPe",
        "title": "Workload-Aware Elastic Striping With Hot Data Identification for SSD RAID Arrays.",
        "abstract": "Redundant array of independent disk (RAID) offers a good option to provide device-level fault tolerance for solid-state drives (SSDs). However, parity update with either read–modify–write or read–reconstruct–write may introduce a lot of extra I/Os and thus significantly degrades SSD RAID performance. To reduce the parity update cost, elastic striping chooses to reconstruct new stripes with only the newly updated data chunks instead of directly updating parity chunks. However, it necessitates an RAID-level garbage collection (GC) process, which may incur a very high cost due to the mixture of hot and cold data chunks. To address this problem, we follow the idea of elastic striping and propose a workload-aware scheme (WAS) to reduce the RAID-level GC cost so as to improve the performance and endurance of SSD RAID. In particular, we first develop a novel lightweight hot data identification scheme which requires only a very small computation time and memory cost, then propose a hotness-aware elastic striping approach to separately write data chunks with different hotness to different regions in SSD RAID. To evaluate the effectiveness and efficiency of our WAS, we implement a prototype system on RAID-5 and RAID-6 arrays composed of commercial SSDs. Experimental results show that compared to original elastic striping, our scheme reduces 30.0%–70.6% (and 23.9%–63.2%) of chunk writes under the RAID-5 (and RAID-6) settings, and also reduces the average response time by 60.9%–79.3% (and 56.8%–80.9%) for RAID-5 (and RAID-6), respectively. Besides, our scheme also improves the endurance and reliability of SSD RAID compared to original elastic striping.",
        "keywords": [
            "Arrays",
            "Fault tolerance",
            "Fault tolerant systems",
            "Prototypes",
            "Performance evaluation",
            "Memory management"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Biaobiao Shen",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yubiao Pan",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Zhipeng Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "John C. S. Lui",
                "org": "Department of Computer Science and Engineering, Chinese University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. on CAD of Integrated Circuits and Systems",
        "year": 2017
    },
    "6mRH5jwX": {
        "id": "6mRH5jwX",
        "title": "SmartMD: A High Performance Deduplication Engine with Mixed Pages.",
        "abstract": "In hypervisor-based virtualization environments, translation lookaside buffers (TLBs) misses may induce two-dimensional page table walks, which may incur a long access latency, and this issue becomes worse with ever increasing memory capacity. To reduce the overhead of TLB misses, large pages (e.g., 2M-pages) are widely supported in modern hardware platforms to reduce the number of page table entries. However, memory management with large pages can be inefficient in deduplication, leading to low utilization of memory, which is a precious resource for a variety of applications.To simultaneously enjoy benefits of high performance by accessing memory with large pages (e.g., 2M-pages) and high deduplication rate by managing memory with base pages (e.g., 4K-pages), we propose Smart Memory Deduplciation, or SmartMD in short, which is an adaptive and efficient management scheme for mixed-page memory. Specifically, we propose two lightweight schemes to accurately monitor pagesu0027 access frequency and repetition rate, and present a dynamic and adaptive conversion scheme to selectively split or reconstruct large pages. We implement a prototype system and conduct extensive experiments with various workloads. Experiment results show that SmartMD can simultaneously achieve high access performance similar to systems using large pages, and achieves a deduplication rate similar to that applying aggressive deduplication scheme (i.e., KSM) at the same time on base pages.",
        "keywords": "",
        "authors": [
            {
                "name": "Fan Guo",
                "org": "University of Science and Technology of China#TAB#"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China and Collaborative Innovation Center of High Performance Computing, NUDT#TAB#"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China and Anhui Province Key Laboratory of High Performance Computing, USTC#TAB#"
            },
            {
                "name": "Song Jiang",
                "org": "University of Texas, Arlington#TAB#"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong#TAB#"
            }
        ],
        "venue": "USENIX Annual Technical Conference",
        "year": 2017
    },
    "bWYYmmnj": {
        "id": "bWYYmmnj",
        "title": "On detecting malicious behaviors in interactive networks: Algorithms and analysis.",
        "abstract": "",
        "keywords": [
            "wireless mesh network",
            "p2p",
            "protocols",
            "network protocol",
            "security",
            "interaction network"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "COMSNETS",
        "year": 2012
    },
    "7VROuwSV": {
        "id": "7VROuwSV",
        "title": "Stochastic Analysis on RAID Reliability for Solid-State Drives",
        "abstract": "Solid-state drives (SSDs) have been widely deployed in desktops and data centers. However, SSDs suffer from bit errors, and the bit error rate is time dependent since it increases as an SSD wears down. Traditional storage systems mainly use parity-based RAID to provide reliability guarantees by striping redundancy across multiple devices, but the effectiveness of RAID in SSDs remains debatable as parity updates aggravate the wearing and bit error rates of SSDs. In particular, an open problem is that how different parity distributions over multiple devices, such as the even distribution suggested by conventional wisdom, or uneven distributions proposed in recent RAID schemes for SSDs, may influence the reliability of an SSD RAID array. To address this fundamental problem, we propose the first analytical model to quantify the reliability dynamics of an SSD RAID array. Specifically, we develop a \"non-homogeneous\" continuous time Markov chain model, and derive the transient reliability solution. We validate our model via trace-driven simulations and conduct numerical analysis to provide insights into the reliability dynamics of SSD RAID arrays under different parity distributions and subject to different bit error rates and array configurations. Designers can use our model to decide the appropriate parity distribution based on their reliability requirements.",
        "keywords": [
            "transient analysis",
            "solid-state drives",
            "reliability requirements",
            "bit error rate",
            "recent raid scheme",
            "trace-driven simulation",
            "nonhomogeneous continuous time markov chain model",
            "raid",
            "reliability dynamic",
            "ctmc",
            "reliability guarantee",
            "numerical analysis",
            "ssd raid array",
            "multiple device",
            "different parity distribution",
            "disc drives",
            "array configurations",
            "data centers",
            "ssd raid array reliability dynamics",
            "reliability",
            "desktops",
            "parity-based raid",
            "raid reliability",
            "redundancy",
            "transient reliability solution",
            "markov processes",
            "reliability requirement",
            "parity distribution",
            "stochastic analysis"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology University of Science and Technology of China Hefei, China"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "Dept. of Comput. Sci. & Eng., Chinese Univ. of Hong Kong, Hong Kong, China#TAB#"
            },
            {
                "name": "John C. S. Lui",
                "org": "Dept. of Comput. Sci. & Eng., Chinese Univ. of Hong Kong, Hong Kong, China#TAB#"
            }
        ],
        "venue": "Reliable Distributed Systems",
        "year": 2013
    },
    "DOmikZ1Q": {
        "id": "DOmikZ1Q",
        "title": "Measuring and Maximizing Influence via Random Walk in Social Activity Networks.",
        "abstract": "With the popularity of OSNs, finding a set of most influential users (or nodes) so as to trigger the largest influence cascade is of significance. For example, companies may take advantage of the “word-of-mouth” effect to trigger a large cascade of purchases by offering free samples/discounts to those most influential users. This task is usually modeled as an influence maximization problem, and it has been widely studied in the past decade. However, considering that users in OSNs may participate in various kinds of online activities, e.g., giving ratings to products, joining discussion groups, etc., influence diffusion through online activities becomes even more significant.",
        "keywords": "",
        "authors": [
            {
                "name": "Pengpeng Zhao",
                "org": "University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Hong Xie",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Zhiyong Wu",
                "org": "University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China, Hefei, China"
            },
            {
                "name": "John C. S. Lui",
                "org": "The Chinese University of Hong Kong, Hong Kong, China"
            }
        ],
        "venue": "DASFAA",
        "year": 2017
    },
    "SpCsns3m": {
        "id": "SpCsns3m",
        "title": "Optimizing Discount & Reputation Trade-offs in E-commerce Systems: Characterization and Online Learning",
        "abstract": "Feedback-based reputation systems are widely deployed in E-commerce systems. Evidences showed that earning a reputable label (for sellers of such systems) may take a substantial amount of time and this implies a reduction of profit. We propose to enhance sellers' reputation via price discounts. However, the challenges are: (1) The demands from buyers depend on both the discount and reputation; (2) The demands are unknown to the seller. To address these challenges, we first formulate a profit maximization problem via a semiMarkov decision process (SMDP) to explore the optimal trade-offs in selecting price discounts. We prove the monotonicity of the optimal profit and optimal discount. Based on the monotonicity, we design a QLFP (Q-learning with forward projection) algorithm, which infers the optimal discount from historical transaction data. We conduct experiments on a dataset from to show that our QLFP algorithm improves the profit by as high as 50% over both the classical Q-learning and speedy Q-learning algorithm. Our QLFP algorithm also improves the profit by as high as four times over the case of not providing any price discount.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Xie",
                "org": "Chongqing Univ, Coll Comp Sci, Chongqing, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Univ Sci & Technol China, Sch Comp Sci & Technol, Hefei, Anhui, Peoples R China"
            },
            {
                "name": "John C. S. Lui",
                "org": "Chinese Univ Hong Kong, Dept Comp Sci & Engn, Hong Kong, Peoples R China"
            }
        ],
        "venue": "THIRTY-THIRD AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE / THIRTY-FIRST INNOVATIVE APPLICATIONS OF ARTIFICIAL INTELLIGENCE CONFERENCE / NINTH AAAI SYMPOSIUM ON EDUCATIONAL ADVANCES IN ARTIFICIAL INTELLIGENCE",
        "year": 2019
    },
    "4wMekVCj": {
        "id": "4wMekVCj",
        "title": "UniKV - Toward High-Performance and Scalable KV Storage in Mixed Workloads via Unified Indexing.",
        "abstract": "Persistent key-value (KV) stores are mainly designed based on the Log-Structured Merge-tree (LSM-tree), which suffer from large read and write amplifications, especially when KV stores grow in size. Existing design optimizations for LSM-tree-based KV stores often make certain trade-offs and fail to simultaneously improve both the read and write performance on large KV stores without sacrificing scan performance. We design UniKV, which unifies the key design ideas of hash indexing and the LSM-tree in a single system. Specifically, UniKV leverages data locality to differentiate the indexing management of KV pairs. It also develops multiple techniques to tackle the issues caused by unifying the indexing techniques, so as to simultaneously improve the performance in reads, writes, and scans. Experiments show that UniKV significantly outperforms several state-of-the-art KV stores (e.g., LevelDB, RocksDB, HyperLevelDB, and PebblesDB) in overall throughput under read-write mixed workloads.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiang Zhang",
                "org": "Univ. of Science & Technology of China#TAB#"
            },
            {
                "name": "Yongkun Li",
                "org": "Univ. of Science & Technology of China#TAB#"
            },
            {
                "name": "Patrick P. C. Lee",
                "org": "The Chinese university of Hong Kong"
            },
            {
                "name": "Yinlong Xu",
                "org": "Univ. of Science & Technology of China#TAB#"
            },
            {
                "name": "Qiu Cui",
                "org": "PingCAP"
            },
            {
                "name": "Liu Tang",
                "org": "PingCAP"
            }
        ],
        "venue": "ICDE",
        "year": 2020
    },
    "eziVLDO7": {
        "id": "eziVLDO7",
        "title": "I/O-Efficient Scaling Schemes for Distributed Storage Systems with CRS Codes.",
        "abstract": "System scaling becomes essential and indispensable for distributed storage systems due to the explosive growth of data volume. Considering that fault-protection is a necessity in large-scale distributed storage systems, and Cauchy Reed-Solomon (CRS) codes are widely deployed to tolerate multiple simultaneous node failures, this paper studies the scaling problem of distributed storage systems with CRS codes. In particular, we formulate the scaling problem with an optimization model in which both the post-scaling encoding matrix and the data migration policy are assumed to be unknown in advance. To minimize the I/O overhead, we propose a three-phase optimization scaling scheme for CRS codes. Specifically, we first derive the optimal post-scaling encoding matrix under a given data migration policy, then optimize the data migration process using the selected post-scaling encoding matrix, and finally exploit the Maximum Distance Separable (MDS) property to further optimize the designed data migration process. Our scaling scheme requires minimal data movement while achieving uniform data distribution. Moreover, it requires to read fewer data blocks than conventional minimum data migration schemes, but still guarantees the minimum amount of migrated data. To validate the efficiency of our scheme, we implement it atop a networked file system. Extensive experiments show that our scaling scheme uses less scaling time than the basic scheme.",
        "keywords": [
            "Encoding",
            "Optimization",
            "Data models",
            "Algorithm design and analysis",
            "Distributed databases",
            "Reed-Solomon codes",
            "Layout"
        ],
        "authors": [
            {
                "name": "Si Wu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China and the AnHui Province Key Laboratory of High Performance ComputingUniversity of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China and the Collaborative Innovation Center of High Performance Computing, National University of Defense Technology, China, Changsha, China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China and the AnHui Province Key Laboratory of High Performance ComputingUniversity of Science and Technology of China"
            },
            {
                "name": "Zhijia Yang",
                "org": "School of Computer Science and TechnologyUniversity of Science and Technology of China"
            }
        ],
        "venue": "IEEE Trans. Parallel Distrib. Syst.",
        "year": 2016
    },
    "tkd8Vnw9": {
        "id": "tkd8Vnw9",
        "title": "Identifying Pollution Attackers in Network-Coding Enabled Wireless Mesh Networks.",
        "abstract": "",
        "keywords": [
            "network coding",
            "indexing terms",
            "routing protocols",
            "probability distribution",
            "simulation",
            "false positive",
            "encoding",
            "routing protocol",
            "pollution",
            "statistical distributions",
            "wireless mesh network"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "John C. S. Lui",
                "org": ""
            }
        ],
        "venue": "ICCCN",
        "year": 2011
    },
    "EdU923un": {
        "id": "EdU923un",
        "title": "Walking with Perception: Efficient Random Walk Sampling via Common Neighbor Awareness",
        "abstract": "Random walk is widely applied to sample large-scale graphs due to its simplicity of implementation and solid theoretical foundations of bias analysis. However, its computational efficiency is heavily limited by the slow convergence rate (a.k.a. long burn-in period). To address this issue, we propose a common neighbor aware random walk framework called CNARW, which leverages weighted walking by differentiating the next-hop candidate nodes to speed up the convergence. Specifically, CNARW takes into consideration the common neighbors between previously visited nodes and next-hop candidate nodes in each walking step. Based on CNARW, we further develop two efficient \"unbiased sampling\" schemes. Experimental results on real-world network datasets show that our approach converges remarkably faster than the state-of-the-art random walk sampling algorithms. Furthermore, to achieve the same estimation accuracy, our approach reduces the query cost (a measure of sampling budget) significantly. Lastly, we also use two case studies to demonstrate the effectiveness of our sampling framework in solving large-scale graph analysis tasks.",
        "keywords": [
            "Convergence",
            "Legged locomotion",
            "Estimation",
            "Task analysis",
            "Computer science",
            "Probability distribution",
            "Markov processes"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Zhiyong Wu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Shuai Lin",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Hong Xie",
                "org": "Chongqing University"
            },
            {
                "name": "Min Lv",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "John C.S. Lui",
                "org": "The Chinese University of Hong Kong"
            }
        ],
        "venue": "2019 IEEE 35th International Conference on Data Engineering (ICDE)",
        "year": 2019
    },
    "jxF9KAWh": {
        "id": "jxF9KAWh",
        "title": "Boosting performance of SSD with chip-level RAID by deferring garbage collection.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Liang",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            },
            {
                "name": "Yongkun Li",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            },
            {
                "name": "Hao Chen",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            },
            {
                "name": "Yinlong Xu",
                "org": "School of Computer Science and Technology, University of Science and Technology of China"
            }
        ],
        "venue": "IEICE Electronic Express",
        "year": 2018
    },
    "y0GMZqyi": {
        "id": "y0GMZqyi",
        "title": "Improved Stabilization for Continuous Dynamical Systems with Two Additive Time-Varying Delays: Stabilization for Dynamical Systems with Two Additive Time-Varying Delays",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lianglin xiong",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "weihong zhou",
                "org": ""
            }
        ],
        "venue": "Asian Journal of Control",
        "year": 2015
    },
    "AeShRRcr": {
        "id": "AeShRRcr",
        "title": "Improved Stabilization for Continuous Dynamical Systems with Two Additive Time‐Varying Delays",
        "abstract": "This paper studies the problem of stabilization criteria for systems with two additive time-varying delays. First, the delay-dependent stability condition for the systems is established through computing the more general Lyapunov functional. The Lyapunov functional is constructed by making full use of the property and the information of the systems, and the condition has advantages over the existing ones in the skillful combination of the delay decomposition and the reciprocal convex approach. Second, considered to be more flexible for the controller design with the introduced positive scalar, a new controller method is presented. Finally, two examples are provided to demonstrate the advantage of the results in this paper.",
        "keywords": [
            "Additive time-varying delay",
            "delay-dependent stabilization",
            "Lyapunov functional",
            "reciprocally convex approach"
        ],
        "authors": [
            {
                "name": "lianglin xiong",
                "org": "Yunnan Univ, Sch Math & Stat, Kunming 650091, Peoples R China"
            },
            {
                "name": "yongkun li",
                "org": "Yunnan Univ, Sch Math & Stat, Kunming 650091, Peoples R China"
            },
            {
                "name": "weihong zhou",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650500, Peoples R China"
            }
        ],
        "venue": "ASIAN JOURNAL OF CONTROL",
        "year": 2015
    },
    "ni9CdzVa": {
        "id": "ni9CdzVa",
        "title": "Improved Stabilization Criteria for Neutral Time-Delay Systems",
        "abstract": "This paper addresses the stabilization conditions for neutral systems with mixed time delays. By constructing a novel class of Lyapunov functionals which contains an augmented Lyapunov functional, using a new class of improved Jensen's like inequalities, two improved delay-dependent stability criteria are firstly established. Next, state feedback controllers are designed according to the stability conditions in different cases. Finally, five numerical examples are provided to demonstrate the theoretical results.",
        "keywords": "",
        "authors": [
            {
                "name": "Lianglin Xiong",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650500, Peoples R China"
            },
            {
                "name": "Haiyang Zhang",
                "org": "Yunnan Minzu Univ, Sch Math & Comp Sci, Kunming 650500, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Sch Math & Stat, Kunming 650091, Peoples R China"
            },
            {
                "name": "Zixin Liu",
                "org": "GuiZhou Univ Finance & Econ, Sch Math & Stat, Guiyang 550025, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL PROBLEMS IN ENGINEERING",
        "year": 2016
    },
    "lpiexuzL": {
        "id": "lpiexuzL",
        "title": "Improved stability and H∞ performance for neutral systems with uncertain Markovian jump",
        "abstract": "This paper addresses the problem of the delay-dependent stability and H∞ performance for neutral systems with uncertain Markovian jump; the uncertainty of Markovian jump refers to the partial information on transition probability. In order to highlight the methods for the analysis of the systems, the neutral delay is assumed same as discrete delay. By the novel constructed Lyapunov functional, combining with the delay decomposition technique and free matrices, and using the new inequality rather than the Jensen inequality, the delay-dependent stability conditions are firstly obtained for the two kinds of neutral dynamical systems. Based on the stability condition, the H∞ performance result for the systems with Markovian jump is secondly provided. All of the delay-dependent stabilization results are formulated in terms of LMIs, which can be easily checked by the LMI control toolbox in Matlab. Finally, two numerical examples are given to show the validity and potential of the developed criteria.",
        "keywords": [
            "Neutral Markovian jump systems",
            "Delay-dependent stabilization",
            "Partly unknown transition probability",
            "New integral inequality",
            "Linear matrix inequality (LMI)"
        ],
        "authors": [
            {
                "name": "lianglin xiong",
                "org": "School of Mathematics and Statistics, Yunnan University, Kunming, 650091, China"
            },
            {
                "name": "haiyang zhang",
                "org": "School of Mathematics and Computer Science, Yunnan Minzu University, Kunming, 650500, China"
            },
            {
                "name": "yongkun li",
                "org": "School of Mathematics and Statistics, Yunnan University, Kunming, 650091, China"
            },
            {
                "name": "zixin liu",
                "org": "School of Mathematics and Statistics, GuiZhou University of Finance and Economics, Guiyang, 550025, China"
            }
        ],
        "venue": "Nonlinear Analysis: Hybrid Systems",
        "year": 2016
    },
    "mzu0gU0K": {
        "id": "mzu0gU0K",
        "title": "Novel Stability Analysis for Uncertain Neutral-Type Lur’e Systems with Time-Varying Delays Using New Inequality",
        "abstract": "This paper considers the delay-dependent stability analysis of neutral-type Lur'e systems with time-varying delays and sector bounded nonlinearities. First of all, using constructed function methods, a new Jensen-like inequality is introduced to obtain less conservative results. Second, a new class of Lyapunov-Krasovskii functional (LKF) is constructed according to the characteristic of the considered systems. Third, combining with the new inequality and reciprocal convex approach and some other inequality techniques, the new less conservative robust stability criteria are shown in the form of linear matrix inequalities (LMIs). Finally, three examples demonstrate the feasibility and the superiority of our methods.",
        "keywords": "",
        "authors": [
            {
                "name": "Yanmeng Wang",
                "org": "Nanjing Univ Aeronaut & Astronaut, Coll Sci, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Lianglin Xiong",
                "org": "Yunnan Minzu Univ, Math & Comp Sci, Kunming, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Yunnan Univ, Sch Math & Stat, Kunming, Peoples R China"
            },
            {
                "name": "Haiyang Zhang",
                "org": "Nanjing Univ Sci & Technol, Sch Sci, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Chen Peng",
                "org": "Yunnan Minzu Univ, Math & Comp Sci, Kunming, Peoples R China"
            }
        ],
        "venue": "MATHEMATICAL PROBLEMS IN ENGINEERING",
        "year": 2017
    },
    "RI84vTCI": {
        "id": "RI84vTCI",
        "title": "Argatroban for preventing occlusion and restenosis after extracranial artery stenting.",
        "abstract": "Background/Aims: Restenosis following extracranial artery stenting is a limitation that affects long-term outcomes. Effective and satisfying pharmacological strategies in preventing restenosis have not been established. This study aimed to evaluate whether argatroban, a direct thrombin inhibitor, could reduce the risk of in-stent restenosis after extracranial artery stenting. Methods: One hundred and fourteen patients hospitalized between August 2010 and August 2011 were enrolled. Patients were randomly assigned to argatroban (n = 58) and blank control groups (n = 56). The patients in the argatroban arm were treated with 10 mg of intravenous argatroban twice daily 2 days before and 3 days after the stenting procedures. Patients were followed for 12 months after the procedure. During follow-up, restenosis and target revascularization were analyzed. Recurrent cerebrovascular and cardiovascular events and deaths were also compared between the groups. Results: One patient in the stenting group withdrew immediately after the procedure due to unsuccessful stenting. Restenosis occurred in 4 patients (7.4%) in the argatroban group and in 11 patients (21.6%) in the control group during the 6- to 9-month angiographic follow-up period (p = 0.032). Nine months after the procedures, argatroban-treated patients had a trend towards a lower incidence of target revascularization compared with the controls (5.4 vs. 13.7%, p = 0.188). No major bleeding events or other adverse events occurred in the argatroban group. Conclusion: This pilot clinical trial is the first that uses argatroban to prevent restenosis in ischemic cerebrovascular disease, and suggests that intravenous administration of argatroban is effective and safe in preventing restenosis after extracranial artery stenting. Larger randomized controlled clinical trials are warranted. (C) 2014 S. Karger AG, Basel",
        "keywords": [
            "Argatroban",
            "Restenosis",
            "Thrombin",
            "Extracranial artery stenting"
        ],
        "authors": [
            {
                "name": "Lulu Zhou",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Dezhi Liu",
                "org": "Nanjing Univ, Jinling Hosp, Sch Med, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Yun Li",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wen Sun",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Yunyun Xiong",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Zhaoyao Chen",
                "org": "Nanjing Univ, Affiliated Hosp, TCM, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Qizhang Wang",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Qiankun Cai",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Zhaolu Wang",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Xiaomeng Wang",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wenshan Sun",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Liang Ge",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Minmin Ma",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Min Li",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Hua Li",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Xinying Fan",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Qin Yin",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Gelin Xu",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "George Liu",
                "org": "Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China"
            },
            {
                "name": "Xiaobing Fan",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            }
        ],
        "venue": "EUROPEAN NEUROLOGY",
        "year": 2014
    },
    "webk9UT1": {
        "id": "webk9UT1",
        "title": "Learning curve for intracranial angioplasty and stenting in single center.",
        "abstract": "ObjectiveTo identify the specific caseload to overcome learning curve effect based on data from consecutive patients treated with Intracranial Angioplasty and Stenting (IAS) in our center. BackgroundThe Stenting and Aggressive Medical Management for Preventing Recurrent Stroke and Intracranial Stenosis trial was prematurely terminated owing to the high rate of periprocedural complications in the endovascular arm. To date, there are no data available for determining the essential caseload sufficient to overcome the learning effect and perform IAS with an acceptable level of complications. MethodsBetween March 2004 and May 2012, 188 consecutive patients with 194 lesions who underwent IAS were analyzed retrospectively. The outcome variables used to assess the learning curve were periprocedural complications (included transient ischemic attack, ischemic stroke, vessel rupture, cerebral hyperperfusion syndrome, and vessel perforation). Multivariable logistic regression analysis was employed to illustrate the existence of learning curve effect on IAS. A risk-adjusted cumulative sum chart was performed to identify the specific caseload to overcome learning curve effect. ResultsThe overall rate of 30-days periprocedural complications was 12.4% (24/194). After adjusting for case-mix, multivariate logistic regression analysis showed that operator experience was an independent predictor for periprocedural complications. The learning curve of IAS to overcome complications in a risk-adjusted manner was 21 cases. ConclusionsOperator's level of experience significantly affected the outcome of IAS. Moreover, we observed that the amount of experience sufficient for performing IAS in our center was 21 cases. (c) 2013 Wiley Periodicals, Inc.",
        "keywords": [
            "learning curve",
            "complications",
            "intracranial angioplasty and stenting",
            "risk-adjusted cumulative sum"
        ],
        "authors": [
            {
                "name": "Qiankun Cai",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Gelin Xu",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wen Sun",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Yunyun Xiong",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Wenshan Sun",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Yuanfei Bao",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Xianjun Huang",
                "org": "Wannan Med Coll, Yijishan Hosp, Dept Neurol, Wuhu, Anhui, Peoples R China"
            },
            {
                "name": "Yao Zhang",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Lulu Zhou",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210008, Jiangsu, Peoples R China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing 210002, Jiangsu, Peoples R China"
            }
        ],
        "venue": "CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS",
        "year": 2014
    },
    "ud4Og9v8": {
        "id": "ud4Og9v8",
        "title": "Learning curve for intracranial angioplasty and stenting in single center: Learning Curve for IAS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xinfeng liu",
                "org": ""
            },
            {
                "name": "wusheng zhu",
                "org": ""
            },
            {
                "name": "lulu zhou",
                "org": ""
            },
            {
                "name": "yao zhang",
                "org": ""
            },
            {
                "name": "xianjun huang",
                "org": ""
            },
            {
                "name": "yuanfei bao",
                "org": ""
            },
            {
                "name": "yunyun xiong",
                "org": ""
            },
            {
                "name": "wen sun",
                "org": ""
            },
            {
                "name": "gelin xu",
                "org": ""
            },
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "qiankun cai",
                "org": ""
            }
        ],
        "venue": "Catheterization and Cardiovascular Interventions",
        "year": 2013
    },
    "BrtmQTOF": {
        "id": "BrtmQTOF",
        "title": "Feasibility and safety of stenting for symptomatic carotid arterial dissection.",
        "abstract": "Objective: To determine the procedural feasibility and safety of carotid angioplasty and stent placement of carotid artery dissection (CAD) patients who had failed antithrombotic therapy in acute dissection. Methods: A series of 33 consecutive patients (mean age, 40.21 years; 29 men and 4 women) who underwent angioplasty and stent placement for symptomatic carotid artery dissection (sCAD) from May 2005 to December 2010 in the Nanjing Stroke Registry Program (NSRP) was retrospectively reviewed. All the included patients had been diagnosed definitively based on catheter angiography, and had failed to respond to medical therapy during the course of initial hospital admission. The baseline and followed up data of these patients were collected and analyzed. Results: Of all the 33 included patients, 32 patients had achieved technical success without any intraoperative complications. Two patients manifested ipsilateral Horner sign on the next day after stenting, and one of them suffered from recurrence of transient ischaemic attack (TIA) during the course of follow up, but completely remission via antithrombotic therapy. Conclusion: Endovascular stenting is a feasible and safe therapeutic strategy of CAD patients who have failed medical therapy. Copyright (C) 2011 S. Karger AG, Basel",
        "keywords": [
            "Carotid artery dissection",
            "Stent",
            "Stroke",
            "Transient ischaemic attack"
        ],
        "authors": [
            {
                "name": "Q Yin",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            },
            {
                "name": "Y Li",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            },
            {
                "name": "X Fan",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            },
            {
                "name": "M Ma",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            },
            {
                "name": "G Xu",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            },
            {
                "name": "X Liu",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            },
            {
                "name": "W Zhu",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Dept Neurol, Nanjing 210002, Peoples R China"
            }
        ],
        "venue": "CEREBROVASCULAR DISEASES",
        "year": 2011
    },
    "vQAf70Xq": {
        "id": "vQAf70Xq",
        "title": "Safety and efficacy of simultaneous bilateral carotid angioplasty and stenting",
        "abstract": "In this study, we aimed to evaluate the safety and feasibility of simultaneous bilateral carotid artery stenting (BCAS) compared with staged BCAS in patients with bilateral atherosclerotic carotid stenosis (BCS). From January 2004 to March 2012, 68 patients who underwent BCAS were identified from the Nanjing Stroke Registry Program. Of these patients, 42 (61.8 %) underwent simultaneous BCAS (simultaneous group), and 26 (38.2 %) underwent staged BCAS (staged group). We compared demographic data, major vascular risk factors, procedural parameters, and 30 day outcomes between the simultaneous and staged groups. No significant differences were detected in baseline data between the groups. Patients in the simultaneous group had a lower post-operative systolic pressure compared with the staged group (119.1 �� 16.1 vs. 130.2 �� 17.5 mmHg, P = 0.009). Technical success was 100 % of patients in the simultaneous group and 98.1 % in the staged group. Hemodynamic depression was observed in 57.4 % of procedures, with no significant difference between groups in the rate of HD. Four (5.9 %) patients had neurological complications within 30 days, including two cases of hyperperfusion syndrome in the simultaneous group, and two ischemic events in the staged group. There was no significant difference in the 30 day complication rate between the simultaneous and staged groups (4.8 vs. 7.7 %, P = 0.633). Simultaneous BCAS may be safe and feasible for most patients with BCS, with a similar 30 day complication rate to staged BCAS. Multicenter randomized control studies with larger sample sizes are warranted to further explore the safety and efficacy of simultaneous BCAS. ? 2013 Springer Science+Business Media New York.",
        "keywords": [
            "Bilateral carotid stenosis",
            "Carotid artery stenting",
            "Cerebral hyperperfusion syndrome",
            "Hemodynamic depression"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wenshan Sun",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Wenshan Sun",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Yinzhou Wang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Yinzhou Wang",
                "org": "Fujian Medical University(Fujian Medical University),Fuzhou,China"
            },
            {
                "name": "Qiankun Cai",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Zhixin Huang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wenhua Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Yunyun Xiong",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Gelin Xu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            }
        ],
        "venue": "Journal of Thrombosis and Thrombolysis",
        "year": 2014
    },
    "QAeqHJ25": {
        "id": "QAeqHJ25",
        "title": "Relationship between cytochrome P450 2C19 polymorphisms and clinical outcomes in clopidogrel -treated patients who underwent cerebrovascular stenting placement",
        "abstract": "Objective: To evaluate the impact of cytochrome P450 (CYP) 2C19 gene polymorphisms on clinical outcome in clopidogrel-treated patients who underwent cerebrovascular stenting placement. Methods: One hundred and ninty-four patients who underwent cerebrovascular stent placement and with long-term treatment of clopidogrel (75 mg/d) between April 2009 and December 2010 were enrolled, CYP2C19 genotype was detected by improved multiple ligase detection reaction. The primary clinical endpoints were ischemic stroke and death after stent implantation; the key secondary endpoints were hemorrhagic stroke and other vascular events. Results: The average followed-up was (19.4 ±9.9) months. The overall incidence of primary endpoints was 16.5%. Of the 194 patients, 87(44.8%) were wild-type homozygous, 88 (45.4%) were heterozygotes, and 19 (9.8%) were homozygous. The cumulative incidence of adverse outcomes was significant higher in CYP2C19* 2 carrier than that in noncarriers (22.4% (24/107) vs 9.2% (8/87), HR=2.74, 95% CI 1.23-6.10, P = 0.01). Of the 194 patients, 13 (6.7%) were heterozygotes, and 181 (93.3%) were wild-type homozygous. CYP2C19* 3 polymorphism had no significant impact on the outcomes in this cohort of patients. No relationship between gene and the secondary endpoints were detected. After multivariable analysis, the CYP2C19* 2 was an independent predictor of clinical outcomes of cerebrovascular stent placement (HR = 2.89, 95% CI 1.10-7.60, P = 0.03). Conclusions: CYP2C19* 2 is an independent determinant of adverse events after cerebrovascular stent placement treated with clopidogrel. While CYP2C19* 3 is not associated with the clinical prognosis in patients with cerebrovascular stent placement. Copyright © 2013 by the Chinese Medical Association.",
        "keywords": [
            "Aryl hydrocarbon hydroxylases",
            "Brain ischemia",
            "Polymorphism",
            " genetic",
            "Prognosis",
            "Stents",
            "Stroke",
            "Ticlopidine"
        ],
        "authors": [
            {
                "name": "Wenshan Sun",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Zhizhong Zhang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "MingQuan Li",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Xiaomeng Wang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "LiLi Tian",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Qin Yin",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Xiaobing Fan",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Gelin Xu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            }
        ],
        "venue": "Chinese Journal of Neurology",
        "year": 2013
    },
    "VcUUXlC2": {
        "id": "VcUUXlC2",
        "title": "Matrix metalloproteinase 9 level as an indicator for restenosis following cervical and intracranial angioplasty and stenting",
        "abstract": "Cervical and intracranial angioplasty and stenting is an effective and safe method of reducing the risk of ischemic stroke, but it may be affected by in-stent restenosis. The present study investigated serum level of matrix metalloproteinase 9 as a predictor of restenosis after 40 patients underwent cervical and/or intracranial angioplasty and stenting. Results showed that restenosis occurred in 30% (3/10) of patients when the serum level of matrix metalloproteinase 9 at 3 days after surgery was 2.5 times higher than preoperative level. No restenosis occurred when the serum level of matrix metalloproteinase 9 at 3 days after surgery was not 2.5 times higher than preoperative level. Restenosis occurred in 12% (2/17) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for more than 30 days after surgery, but only occurred in 4% (1/23) of patients when the serum level of matrix metalloproteinase 9 was higher than preoperative level for less than 30 days after surgery. However, the differences observed were not statistically significant (P > 0.05). Experimental findings indicate that when the serum level of matrix metalloproteinase 9 is 2.5 times higher than preoperative level at 3 days after cervical and intracranial angioplasty and stenting, it may serve as a predictor of in-stent restenosis. ",
        "keywords": [
            "cervical and intracranial angioplasty and stenting",
            "intracranial artery stenosis",
            "matrix metalloproteinase 9",
            "nerve regeneration",
            "neural regeneration",
            "restenosis"
        ],
        "authors": [
            {
                "name": "junpeng liu",
                "org": "fujian medical university"
            },
            {
                "name": "yinzhou wang",
                "org": "fujian medical university"
            },
            {
                "name": "yongkun li",
                "org": "fujian medical university"
            },
            {
                "name": "qiong cheng",
                "org": "fujian medical university"
            },
            {
                "name": "zheng zheng",
                "org": "fujian medical university"
            }
        ],
        "venue": "Neural regeneration research",
        "year": 2015
    },
    "3dJU9k0O": {
        "id": "3dJU9k0O",
        "title": "The value of hyperintense vessel signs on fluid-attenuated inversion recovery imaging for assessing the patterns of collateral blood flow in adult moyamoya disease",
        "abstract": "Objective: To investigate the value of hyperintense vessel signs (HVS) on fluid-attenuated inversion recovery (FLAIR) sequence for assessing the patterns of collateral blood flow in adult moyamoya disease (MMD). Methods: Forty-one adult patients with non-hemorrhagic MMD retrieved from Nanjing Stroke Registry Program between August 2008 and January 2011 were identified by digital cerebral angiography and performed the examination of FLAIR sequence in Jinling hospital. According to the different sites of HVS located in the territory of the middle cerebral artery, the patterns of HVS were classified into grades 0-3; Grade 0, absence of HVS; Grade 1, HVS limited in the cerebral sulci of temporal lobe and Sylvian fissure; Grade 2, HVS in the cerebral sulci of frontal and parietal lobe regions and Sylvian fissure; and Grade 3, HVS in the combined territories of Grade 1 and Grade 2. According to the intracerebral collateral blood flow, steno-occlusions of the arteries were classified into three types; Type 1, residual antegrade flow across steno-occlusive lesions; Type 2, retrograde flow via leptomeningeal vessels; Type 3, the combined collateral blood flow of Type 1 and Type 2. The relationship between the patterns of intracerebral collateral blood flow and the location of HVS was analyzed. Results: Of 41 adult patients with non-hemorrhagic MMD, there were 3 patients presented with unilateral vascular lesions and 38 with bilateral vascular lesions, so the total number of vascular lesions of the cerebral hemispheres was 79. Because three patients showed the absence of HVS in bilateral hemispheres, the total number of the presence of HVS of the cerebral hemispheres was 73. Therefore, the percentage of the presence of HVS was 92.4% (73/79) in vascular lesions of the cerebral hemispheres. Importantly, the patterns of slow collateral blood flow corresponding to Grade 1 HVS were all antegrade (7/7); the collateral patterns corresponding to Grade 2 HVS were mainly retrograde leptomeningeal flow (95.0%, 19/20); and the patterns corresponding to Grade 3 HVS were mainly slow combined collateral blood flow(84.8%, 39/46). Furthermore, with the changing sites of HVS from the cerebral sulci of temporal lobe to the cerebral sulci of frontal and parietal lobe regions, the directions of collateral flow changed with a shift from antegrade to retrograde, which was statistically significant. Conclusion: The different locations of HVS can reflect the different patterns of collateral blood flow, and the locations of HVS may predict the directions of intracerebral collateral blood flow in adult MMD patients.",
        "keywords": [
            "Cerebral angiography",
            "Magnetic resonance imaging",
            "Middle cerebral artery",
            "Moyamoya disease",
            "Regional blood flow"
        ],
        "authors": [
            {
                "name": "Wenhua Liu",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            },
            {
                "name": "Xianjun Huang",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            },
            {
                "name": "Minmin Ma",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            },
            {
                "name": "Gelin Xu",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Jinling Hospital(Jinling Hospital),Nanjing,China"
            }
        ],
        "venue": "Chinese Journal of Neurology",
        "year": 2012
    },
    "JU7vvtcQ": {
        "id": "JU7vvtcQ",
        "title": "Microbleeds in ischemic stroke are associated with lower serum adiponectin and higher soluble E-selectin levels.",
        "abstract": "Cerebral microbleeds (CMBs) are the important indicators of cerebral small vessel disease. However, it is still unclear whether endothelial dysfunction is involved in CMBs. In this study, we performed a prospective study to investigate the correlation between sE-selectin (soluble E-selectin) or adiponectin and the prevalence of CMBs.We recruited 133 consecutive patients with first-ever ischemic stroke for this study. Finally, 126 patients were analyzed. The number and presence of CMBs were detected and evaluated on susceptibility-weighted magnetic resonance imaging within two weeks after symptom onset. We assessed the serum levels of adiponectin and sE-selectin for patients.CMBs were detected in 63 subjects (50%) within 126 patients and more prevalent in mixed brain regions (55.6%). In binary logistic regression analysis, each 1SD-increase in adiponectin level was significantly conversely associated with the prevalence of CMBs after adjusting for age, sex and cardiovascular risk factors (OR = 0.55; 95% CI: 0.36-0.84); but sE-selectin was significantly positively associated with the prevalence of CMBs (OR = 1.09; 95% CI: 1.02-1.15). Furthermore, partial correlation analyses showed that sE-selectin remained significantly associated with and correlated conversely to adiponectin (r = -0.452, p = 0.001).Endothelial injury may play a role in the pathogenesis of CMBs, and serum levels of adiponectin and sE-selectin were closely related to CMBs. Adiponectin might be protective for the prevalence of CMBs.",
        "keywords": [
            "Cerebral microbleeds",
            "Adiponectin",
            "sE-selectin",
            "Endothelial dysfunction",
            "Marker",
            "Ischemic stroke"
        ],
        "authors": [
            {
                "name": "Zhixin Huang",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 21002, China"
            },
            {
                "name": "Qin Yin",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Wen Sun",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 21002, China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Wenhua Liu",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Lulu Xiao",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Zuowei Duan",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 21002, China"
            },
            {
                "name": "Qiankun Cai",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 21002, China"
            },
            {
                "name": "Dezhi Liu",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Minmin Ma",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 21002, China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing 21002, China"
            }
        ],
        "venue": "Journal of the Neurological Sciences",
        "year": 2013
    },
    "wHRQuoja": {
        "id": "wHRQuoja",
        "title": "The long-term outcome of endovascular treatment versus medical treatment for severe intracranial artery stenosis of anterior circulation",
        "abstract": "Objective: To compare long-term outcome by endovascular treatment and medical treatment in severe intracranial atherosclerotic stenosis of anterior circulation. Methods: Consecutive patients in Nanjing Stroke Registry Program who had transient ischemic attack or stroke attributed to severe intracranial atherosclerotic stenosis of anterior circulation were retrospectively reviewed. Patients were either treated with endovascular therapy (endovascular treatment group) or with medicine (medical treatment group). The primary endpoint was any stroke or death within 30 days after enrollment and ischemic events in the territory of qualifying artery beyond 30 days after a revascularization procedure for the qualifying lesion. The secondary endpoint was stroke in territory of qualifying artery beyond 30 days. The cumulative event rates were compared between two groups and identifying the independence risk factors of secondary endpoint. Results: Of the 142 patients enrolled, 69 patients were in endovascular treatment group and 73 patients in medical treatment group. The cumulative event rates of a primary endpoint over time in 30-day, 1-year, 2-year, 3-year in endovascular treatment group and in medical treatment group were 13%, 15%, 21%, 29% and 1%, 15%, 22%, 27%, respectively. The occurrence was not statistically different between two groups. The occurrences of a secondary endpoint in endovascular treatment group and in medical group at 1-year, 2-year, 3-year were 5%, 13%, 15% and 14%, 21%, 34% respectively, and those in endovascular treatment group was significantly lower (P=0.026). Multivariate Cox analysis revealed that therapeutic modality (HR=2.601, 95% CI 1.042-6.495, P=0.041) and the number of major vascular risk factors (HR=3.322, 95% CI 1.116-9.894, P=0.031) are independence risk factors for stroke in territory of qualifying artery beyond 30 days. Conclusions: The long-term results from endovascular treatment for anterior circulation severe intracranial atherosclerotic stenosis had no statistical difference comparing with that of medical treatment. But the effect of endovascular treatment in preventing stroke in territory of qualifying artery was superior to medical treatment beyond 30 days. Copyright © 2013 by the Chinese Medical Association.",
        "keywords": [
            "Constriction",
            " pathologic",
            "Drug therapy",
            "Intracranial arteriosclerosis",
            "Stents",
            "Treatment outcome"
        ],
        "authors": [
            {
                "name": "Qiankun Cai",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Maogang Chen",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yongkun Li",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yuanfei Bao",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wen Sun",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Min Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Lulu Zhou",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Dezhi Liu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Gelin Xu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "Chinese Journal of Neurology",
        "year": 2013
    },
    "CmSq2JWr": {
        "id": "CmSq2JWr",
        "title": "Reduced endothelial progenitor cells in extracranial arterial stenosis but not intracranial arterial stenosis.",
        "abstract": "Endothelial progenitor cells (EPCs) are novel markers of endothelial dysfunction and are related to cardiovascular disease. However, their relationship with cerebral atherosclerosis (CA) has not been investigated extensively. We aim to study the relationship between CA severity and EPC subpopulations levels.We enrolled 197 patients in this study. EPCs were measured by flow cytometry. Digital subtraction angiography was used to assess CA. Arterial lesion severity was evaluated among cerebral arteries which showed steno-occlusion change and the extent of that condition.There was a significant inverse correlation between EPCs level and CA prevalence after adjusting for confounders (CD45(-/dim)CD34(+)CD309(+) cells: odds ratio [OR], 0.110; 95% confidence interval [CI], 0.026-0.475; P = .00; CD45(-/dim)CD133(+)CD309(+) cells: OR, 0.134; 95% CI, 0.030-0.599; P = .01; CD45(-/dim) CD34(+)CD133(+)CD309(+) cells: OR, 0.010; 95% CI, 0.001-0 .541, P = .02). Multivariate logistic regression analysis showed that only the EPCs level was significantly inversely associated with extracranial atherosclerosis rather than intracranial atherosclerosis (P > .05).Our data indicated that EPCs subpopulations were independent predictors for CA severity, even after controlling for traditional risk factors.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhixin Huang",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China"
            },
            {
                "name": "Xiaohao Zhang",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"
            },
            {
                "name": "Haixia Zhang",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"
            },
            {
                "name": "Ruidong Ye",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"
            },
            {
                "name": "Yunyun Xiong",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China"
            },
            {
                "name": "Wen Sun",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Neurology, Provincial Clinical Department of Fujian Medical University, Fuzhou, China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China"
            }
        ],
        "venue": "Journal of Vascular Surgery",
        "year": 2015
    },
    "PlCiGmIn": {
        "id": "PlCiGmIn",
        "title": "Stereotactic aspiration plus subsequent thrombolysis for moderate thalamic hemorrhage.",
        "abstract": "This study aimed to evaluate the efficacy and safety of stereotactic aspiration combined with subsequent thrombolysis in treating moderate thalamic hemorrhage (TH).A total of 105 patients with TH were nonrandomly assigned to the conservative treatment group (n = 60) or to the aspiration group (n = 45). Patients in the aspiration group were treated with stereotactic aspiration plus subsequent thrombolysis for removal for their hematomas.The 30-day mortality in the conservative group was significantly higher than that in the aspiration group (28.3% (17/60) vs. 11.2% (5/45), P = 0.032). The rank of the 30-day Glasgow outcome scale in the conservative group was significantly lower than that in the aspiration group (P = 0.041), and the mean 30-day National Institutes of Health Stroke Scale score of the survivors in the conservative group was significantly higher than that in the aspiration group (16.5 ± 4. 2 vs. 14.2 ± 3.9, P = 0.012). There were a greater reduction in TH volume in the aspiration group than in the conservative group from day 1 to day 3 (-0.24% and 39.28%, respectively, P < 0.0001) and from day 1 to day 7 (26.58% and 63.26%, respectively, P < 0.0001). The rank of 90-day Glasgow outcome scale was significantly lower in the conservative group than that in the aspiration group (P = 0.015). Eighteen of 60 patients (30.0%) had a favorable outcome in the conservative group, whereas 23 of 45 patients (51.1%) had a favorable outcome in the aspiration group, and this difference was significant (P = 0.028). The 90-day cumulative mortality rate in the conservative group was significantly higher than that in the aspiration group (33.3% (20/60)) vs. 15.6% (7/45), P = 0.039).Stereotactic aspiration plus subsequent thrombolysis is effective and safe for moderate TH.",
        "keywords": [
            "stereotactic aspiration",
            "intracerebral hemorrhage",
            "thalamic hemorrhage",
            "ct",
            "glasgow coma scale",
            "th",
            "gcs"
        ],
        "authors": [
            {
                "name": "Maogang Chen",
                "org": "Department of Neurology, Yancheng City No.1 People’s Hospital (the Fourth Affiliated Hospital of Nantong University), Jiangsu Province, China"
            },
            {
                "name": "Qizhang Wang",
                "org": "Department of Neurology, the Affiliated Shenzhen Shajing Hospital of Guangzhou Medical University (Shajing People's Hospital), Shenzhen, Guangdong Province, China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Qin Yin",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Minmin Ma",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Xinying Fan",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Yongkun Li",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Guanzhong Ni",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Chaolai Liu",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Wenhua Liu",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Renliang Zhang",
                "org": "Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Jiangsu Province, China"
            },
            {
                "name": "Gelin Xu",
                "org": ""
            },
            {
                "name": "Xinfeng Liu",
                "org": ""
            }
        ],
        "venue": "World neurosurgery",
        "year": 2012
    },
    "mV7tH0NI": {
        "id": "mV7tH0NI",
        "title": "Correlation between ABCD, ABCD2 scores and craniocervical artery stenosis in patients with transient ischemic attack.",
        "abstract": "Background and Purpose: Craniocervical artery stenosis is an important etiology for transient ischemic attack (TIA). We hypothesized ABCD and ABCD2 scores can predict craniocervical artery stenosis in patients with TIA. Methods: ABCD and ABCD2 scores were calculated in a total of 479 consecutive first-ever TIA patients in Nanjing Stroke Registry Program and compared with angiographic imaging derived from MRI or invasive catheter-based angiography. Results: Overall craniocervical artery (O-CA) stenosis was found in 197 (41.1%) patients. Extracranial craniocervical artery (E-CA) and intracranial craniocervical artery (I-CA) stenosis was found in 101 (21.1%) and 110 (23%) cases, respectively. ABCD and ABCD2 scores with similar accuracy for O-CA (AUC(ABCD) 0.71, AUC(ABCD2) 0.70), E-CA (AUC(ABCD) 0.72, AUC(ABCD2) 0.72) and I-CA stenosis (AUC(ABCD) 0.62, AUC(ABCD2) 0.62) were both independent predictors for various categories of artery stenosis after being adjusted for non-ABCD2 parameters. The cut-off points were equally 4 in both predicting rules. For ABCD, sensitivity was 57.4, 65.3 and 52.7% and specificity 77.0, 70.4 and 67.5% for O-CA/E-CA/I-CA, respectively. For ABCD2, sensitivity was 61.9, 69.3 and 58.2% and specificity 72.3, 65.6 and 63.1%. Conclusions: In patients with TIA, despite an association between ABCD and ABCD2 scores and underlying craniocervical artery stenosis, the clinical utility was limited by unsatisfactory sensitivity and specificity. (C) 2013 S. Karger AG, Basel",
        "keywords": [
            "Transient ischemic stroke",
            "ABCD score",
            "ABCD2 score",
            "Craniocervical artery stenosis"
        ],
        "authors": [
            {
                "name": "Wen Sun",
                "org": "Southern Med Univ, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Jiafei Dai",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Yunyun Xiong",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Zhixin Huang",
                "org": "Southern Med Univ, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wenhua Liu",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Nanjing Univ, Sch Med, Jinling Hosp, Nanjing 210002, Jiangsu, Peoples R China"
            },
            {
                "name": "Gelin Xu",
                "org": "Southern Med Univ, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Southern Med Univ, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            }
        ],
        "venue": "EUROPEAN NEUROLOGY",
        "year": 2013
    },
    "akd8gL1m": {
        "id": "akd8gL1m",
        "title": "Correlation of extracranial internal carotid artery tortuosity index and intraprocedural complications during carotid artery stenting.",
        "abstract": "Background: To investigate the correlation between tortuosity of extracranial internal carotid artery (EICA) and intraprocedural complications in patients undergoing carotid artery stenting (CAS). Methods: The study included 244 EICA in 223 patients undergoing CAS. Tortuosity in EICA was measured by the tortuosity index (TI). Multivariate logistic regression was performed to assess the independent risk factors of vasospasm during CAS. Receiver operating characteristic curve was performed to identify the cut-off of TI to predict vasospasm. Results: During the 244 CAS, 71 EICA presented vasospasm and 114 CAS presented hypotension. High TI, long procedural duration and female are independent risk factors for vasospasm during CAS. TI of 118 was the optimal cut-off to predict vasospasm during CAS (sensitivity: 85.9%, specificity: 78.6%). Linear regression analysis demonstrated that TI is positively correlated with procedural duration (p < 0.001). There was no significant difference in TI between the hypotension and non-hypotension groups (p = 0.145). Conclusion: TI is an independent risk factor for vasospasm during CAS and a TI >= 118 has the high sensitivity and specificity to predict vasospasm. Our results indicate the value of assessing tortuosity of EICA prior to choosing or performing the procedure in patients with carotid stenosis or occlusion. Copyright (C) 2012 S. Karger AG, Basel",
        "keywords": [
            "Extracranial internal carotid artery",
            "Tortuosity index",
            "Carotid artery stenting",
            "Intraprocedural complications"
        ],
        "authors": [
            {
                "name": "Qizhang Wang",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Chaolai Liu",
                "org": "Jining First Peoples Hosp, Dept Neurol, Jining, Peoples R China"
            },
            {
                "name": "Bernard Yan",
                "org": "Univ Melbourne, Royal Melbourne Hosp, Comprehens Stroke Ctr, Div Neurosci, Parkville, Vic, Australia"
            },
            {
                "name": "Xiaobin Fan",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Min Zhang",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Fujian Med Univ, Prov Clin Dept, Dept Neurol, Fuzhou, Peoples R China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Maogang Chen",
                "org": "Nantong Univ, Affiliated Hosp 4, Yancheng City Peoples Hosp 1, Dept Neurol, Yancheng, Peoples R China"
            },
            {
                "name": "Xianjun Huang",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Zhizhong Zhang",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Gelin Xu",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            },
            {
                "name": "Xinfeng Liu",
                "org": "So Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China"
            }
        ],
        "venue": "EUROPEAN NEUROLOGY",
        "year": 2012
    },
    "4qIKzMN6": {
        "id": "4qIKzMN6",
        "title": "Endovascular stenting for atherosclerotic subclavian artery stenosis in patients with other craniocervical artery stenosis.",
        "abstract": "Atherosclerotic subclavian artery stenosis (SAS) accompanied with other craniocervical artery stenosis (OCAS) is not uncommon in practice. We sought to investigate the safety and efficacy of endovascular stenting for SAS in patients with OCAS. Between January 2004 and February 2012, 71 consecutive atherosclerotic SAS patients who underwent primary stenting in our medical center were included. The enrolled patients were divided into combined-SAS group (n = 51) and solitary-SAS group (n = 20) depending on the presence or absence of OCAS. Data of demographics, procedure, and the followed-up were retrieved and analyzed. The technical success rate was 95.8%; the clinical success rate was 90.1%. There was no catheter-related major stroke or death. The immediate outcomes had no statistical difference between groups. During a mean of 27 ± 20 months (range 2-88 months) followed-up, 7 (10.3%) restenosis and 12 (17.6%) clinical events were identified. The primary patency rate was 95.3, 84.9 and 84.9% at 12, 24 months, and final followed-up respectively, which had no statistical difference between groups (odds ratio (OR), 2.60; 95% confidence interval (CI), 0.54-12.53; P = 0.232). The overall clinical event-free survival rate was 93.5, 86.2 and 54.6%, respectively, where the result of combined-SAS group was inferior to that of the solitary-SAS group (OR, 3.34; 95% CI, 1.02-11.00; P = 0.047). Endovascular stenting was safe and feasible for atherosclerotic SAS in patients with OCAS, although the combined OCAS may have a significant influence on the long-term outcome. Further studies are warrant to investigate the effects of revascularization for multiple craniocervical artery stenoses on the cerebral hemodynamics and long-term outcomes.",
        "keywords": [
            "atherosclerosis",
            "multiple craniocervical artery stenoses",
            "stenting",
            "subclavian artery stenosis",
            "endovascular treatment"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Qin Yin",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Wusheng Zhu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Yinzhou Wang",
                "org": "Fujian Medical University(Fujian Medical University),Fuzhou,China"
            },
            {
                "name": "Xiaobing Fan",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Dezhi Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Maogang Chen",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Qizhang Wang",
                "org": "Guangzhou Medical University (Shajing People's Hospital)(Guangzhou Medical University (Shajing People's Hospital)),Guangdong,China"
            },
            {
                "name": "Gelin Xu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Bernard Yan",
                "org": "University of Melbourne(University of Melbourne),Parkville,Australia"
            },
            {
                "name": "Xinfeng Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            }
        ],
        "venue": "Journal of thrombosis and thrombolysis",
        "year": 2013
    },
    "P9mgq4Dm": {
        "id": "P9mgq4Dm",
        "title": "Plasma homocysteine levels in ischemic stroke patients with obstructive sleep apnea]",
        "abstract": "To investigate the association of plasma homocysteine and OSA (obstructive sleep apnea) syndrome in ischemic stroke (IS).A total of 92 male IS patients were classified by apnea hypopnea index (AHI) into 2 groups: non-OSA group (AHI < 5/h) and OSA group (AHI > or = 5). All patients were tested for plasma homocysteine when polysomnography was finished at (14 +/- 2) d after the onset of IS.The mean level of homocysteine was significantly higher in the OSA group than that in the non-OSA group (17 +/- 5 vs 11 +/- 3 micromol/L, P < 0.01). Pearson correlation analysis revealed a positive correlation between the homocysteine level and the severity of AHI (r = 0.482, P < 0.01). Further multiple linear regression analysis showed that AHI and folate were independent predictors of homocysteine level (R2 = 0.553, P < 0.01, beta for AHI = 0.671, beta for folate = -0.256).The severity of OSA is significantly associated with an elevated level of homocysteine in IS patients. And this association is independent of other causative factors of an elevated level of homocysteine.",
        "keywords": [
            "homocysteine",
            "ischemic stroke",
            "obstructive sleep apnea syndrome",
            "polysomnography"
        ],
        "authors": [
            {
                "name": "Mao-Gang Chen",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Wu-Sheng Zhu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Qin Yin",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Bo-Na Wu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Qi-Zhang Wang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Min-Min Ma",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "De-Zhi Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Yong-Kun Li",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Chao-Lai Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Xian-Jun Huang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Zhao-Yao Chen",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Wan-Xiang Wang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Ge-Lin Xu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Xin-Feng Liu",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2011
    },
    "MqxGVHaQ": {
        "id": "MqxGVHaQ",
        "title": "Electrodeposition of Ni oxide on TiO 2 nanotube arrays for enhancing visible light photoelectrochemical water splitting",
        "abstract": "The photoelectrochemical water splitting into hydrogen and oxygen using sun light is a potentially clean and renewable source of hydrogen fuel. TiO2 nanotubes (NTs) grown by anodization in a fluoride based electrolyte were loaded with Ni oxide nanoparticles by a pulse electrodeposition method. The fabricated NiOx/TiO2NTs electrodes were characterized by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS) and X-ray photoemission spectroscopy (XPS). The photoelectrochemical property of fabricated NiOx/TiO2NTs electrodes was characterized by using a compartment cell. It was found that the Ni oxide nanoparticles loaded enhanced the visible spectrum absorption of the TiO2 nanotube arrays, as well as their solar-spectrum induced photocurrents, while a reverse result was obtained under UV-light illumination. Crown Copyright (c) 2012 Published by Elsevier B.V. All rights reserved.",
        "keywords": [
            "Photoelectrochemical cell",
            "Ni oxide nanoparticles",
            "TiO2 nanotubes",
            "Water splitting",
            "Hydrogen production"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            },
            {
                "name": "hongmei yu",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            },
            {
                "name": "changkun zhang",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            },
            {
                "name": "li fu",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            },
            {
                "name": "guangfu li",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            },
            {
                "name": "zhigang shao",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            },
            {
                "name": "baolian yi",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China"
            }
        ],
        "venue": "Journal of Electroanalytical Chemistry",
        "year": 2013
    },
    "bbFXQHVq": {
        "id": "bbFXQHVq",
        "title": "Simple synthesis of Pt/TiO 2 nanotube arrays with high activity and stability",
        "abstract": "•A simple and efficient strategy was used for the preparation of Pt/TiO2 nanotube.•The electrode exhibited good electrochemical performance and excellent stability.•The performance of electrode is still stable after holding at 1.6 V vs.NHE for 100h.",
        "keywords": [
            "TiO2 nanotube arrays",
            "Pt",
            "Fuel cells",
            "Durability",
            "Hydrogen reduction"
        ],
        "authors": [
            {
                "name": "changkun zhang",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "hongmei yu",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yongkun li",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "li fu",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yuan gao",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "wei song",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "zhigang shao",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "baolian yi",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            }
        ],
        "venue": "Journal of Electroanalytical Chemistry",
        "year": 2013
    },
    "LmEr1Xoz": {
        "id": "LmEr1Xoz",
        "title": "Zeolite-templated Ir x Ru 1−x O 2 electrocatalysts for oxygen evolution reaction in solid polymer electrolyte water electrolyzers",
        "abstract": "IrxRu1−xO2(1 ≥ x ≥ 0) with nanorod structure were successfully synthesized by employed pre-filling the Ir and/or Ru guest species into the peripheral-pore of NH2-modified as-synthesized SBA-15 and explored as electrocatalyst for oxygen evolution reaction (OER) in water electrolyzers. Various physicochemical parameters for zeolite template and/or IrxRu1−xO2 were obtained by SEM, TEM, XRD, EDX and N2 gas absorption/desorption measurements. The morphology for prepared IrxRu1−xO2 samples with individual and/or cluster nanorods was changed with the component difference. Cyclic voltammetry, linear sweep voltammetry, electrochemical impedance spectroscopy, steady state polarization curves and stability tests were performed to investigate the catalytic activity and stability of these electrocatalysts for OER. The cell with catalyst RuO2 showed best catalytic performance with the lowest onset potential (1.374 V at 10 mA cm−2), which may be ascribed to regular nanoclusters and larger outer active surface area. Meanwhile, the cell stability tests suggested that the addition of IrO2 in IrxRu1−xO2 improved the stability of the RuO2 catalyst.",
        "keywords": [
            "Hydrogenation",
            "Iridium–ruthenium oxide",
            "Oxygen evolution reaction",
            "Solid polymer electrolyte water electrolysis",
            "Template synthesis"
        ],
        "authors": [
            {
                "name": "guangfu li",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "hongmei yu",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "wei song",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "xunying wang",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yongkun li",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "zhigang shao",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "baolian yi",
                "org": "Laboratory of Fuel Cells, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            }
        ],
        "venue": "International Journal of Hydrogen Energy",
        "year": 2012
    },
    "qTENzoSU": {
        "id": "qTENzoSU",
        "title": "An Oriented Ultrathin Catalyst Layer Derived from High Conductive TiO 2 Nanotube for Polymer Electrolyte Membrane Fuel Cell",
        "abstract": "An oriented ultrathin catalyst layer (UTCL) has been prepared for fuel cells application based on the high electrical conductivity TiO2 nanotube (TNTs). The electrical conductivity of TNTs was improved by the deposited C via a plasma enhanced chemical vapor deposition (PECVD) technique. Pt catalysts were deposited on the high electrical conductivitve TNTs by the radio frequency (RF) sputtering to form the oriented C-TNTs-Pt electrode. The mass activity of C-TNTs-Pt-1 at 0.85V was about 0.44AmgPt−1. The prepared oriented UTCL based on the C-TNTs-Pt electrode displayed a maximum power density of 206 and 305mWcm−2 at an ultralow Pt loading resulting in a relatively high Pt utilization of 8.3 and 6.0kWg−1Pt. A 2D symmetry model based on the parameters of the oriented UTCL was established. In the model, the performance of fuel cell was improved along with the decreasing of CL thickness. Meanwhile, it is found that there is little effect on the cell performance when the electrical conductivity of CL is larger than 3Scm−1. The study in this work gave effectual evidence on the possibility of using the oriented UTCL for developing low cost fuel cells.",
        "keywords": [
            "fuel cells",
            "oriented ultrathin catalyst layer",
            "TiO2 nanotube",
            "high conductivity",
            "2D symmetry model"
        ],
        "authors": [
            {
                "name": "changkun zhang",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "hongmei yu",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "li fu",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yu xiao",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yuan gao",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yongkun li",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "yachao zeng",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "jia jia",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "baolian yi",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            },
            {
                "name": "zhigang shao",
                "org": "Fuel Cell System and Engineering Laboratory, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China"
            }
        ],
        "venue": "Electrochimica Acta",
        "year": 2015
    },
    "xyHGztJQ": {
        "id": "xyHGztJQ",
        "title": "Highly effective Ir(x)Sn(1-x)O2 electrocatalysts for oxygen evolution reaction in the solid polymer electrolyte water electrolyser.",
        "abstract": "We developed an advanced surfactant-assistant method for the IrxSn1-xO2 (0 < x <= 1) nanoparticle (NP) preparation, and examined the OER performances by a series of half-cell and full-cell tests. In contrast to the commercial Ir black, the collective data confirmed the outstanding activity and stability of the fabricated IrxSn1-xO2 (x = 1, 0.67 and 0.52) NPs, which could be ascribed to the amorphous structure, good dispersion, high pore volume, solid-solution state and Ir-rich surface for bi-metal oxides, and relatively large size (10-11 nm), while Ir0.31Sn0.69 exhibited poor electro-catalytic activity because of the separated two phases, a SnO2-rich phase and an IrO2-rich phase. Furthermore, compared with highly active IrO2, the improved durability, precious-metal Ir utilization efficiency and correspondingly reduced Ir loading were realized by the addition of Sn component. When the Ir0.52Sn0.48O2 cell operated at 80 degrees C using Nafions (R) 115 membrane and less than 0.8 mg cm(-2) of the noble-metal Ir loading, the cell voltages we achieved were 1.631 V at 1000 mA cm(-2), and 1.821 V at 2000 mA cm(-2). The IR-free voltage at the studied current density was very close to the onset voltage of oxygen evolution. The only 50 mu V h(-1) of voltage increased for the 500 h durability test at 500 mA cm(-2). In fact, these results are exceptional compared to the performances for OER in SPEWE cells known so far. This work highlights the potential of using highly active and stable IrO2-SnO2 amorphous NPs to enhance the electrolysis efficiency, reduce the noble-metal Ir loading and thus the cost of hydrogen production from the solid polymer electrolyte water electrolysis.",
        "keywords": [],
        "authors": [
            {
                "name": "Guangfu Li",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            },
            {
                "name": "Hongmei Yu",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            },
            {
                "name": "Xunying Wang",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            },
            {
                "name": "Shucheng Sun",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            },
            {
                "name": "Yongkun Li",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            },
            {
                "name": "Zhigang Shao",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            },
            {
                "name": "Baolian Yi",
                "org": "Chinese Acad Sci, Dalian Inst Chem Phys, Lab Fuel Cells, Dalian 116023, Peoples R China"
            }
        ],
        "venue": "PHYSICAL CHEMISTRY CHEMICAL PHYSICS",
        "year": 2013
    },
    "0Fl4ofi0": {
        "id": "0Fl4ofi0",
        "title": "Positive periodic solutions of discrete n-species food-chain systems",
        "abstract": "Discrete periodic n-species food-chain systems with Holling types II and III functional responses and time delays are investigated, respectively. By using Gaines and Mawhin's continuation theorem of coincidence degree theory sufficient conditions are obtained for the existence of positive periodic solutions of the systems.",
        "keywords": [
            "coincidence degree theory",
            "sufficient condition",
            "positive periodic solution",
            "continuation theorem",
            "iii functional response",
            "discrete n-species",
            "discrete periodic n-species",
            "n -species food-chain systems",
            "time delay",
            "holling type",
            "holling type functional response",
            "food-chain system",
            "functional response",
            "food chain"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Department of Mathematics Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            },
            {
                "name": "Linghong Lu",
                "org": "Department of Mathematics Yunnan University, Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2005
    },
    "Qybe3UNa": {
        "id": "Qybe3UNa",
        "title": "Positive periodic solutions of higher-dimensional nonlinear functional difference equations",
        "abstract": "By using a well-known fixed point index theorem, we study the existence, multiplicity and nonexistence of positive T-periodic solution(s) to the higher-dimensional nonlinear functional difference equations of the form x(n+1)=A(n)x(n)+λh(n)f(x(n−τ(n))),n∈Z, where A(n)=diag[a1(n),a2(n),…,am(n)],h(n)=diag[h1(n),h2(n),…,hm(n)], aj,hj:Z→R+, τ:Z→Z are T-periodic, j=1,2,…,m, T⩾1; λ>0, x:Z→Rm, f:R+m→R+, where R+m={(x1,…,xm)T∈Rm:xj⩾0,j=1,2,…,m}, R+={x∈R:x>0}.",
        "keywords": [
            "Functional difference equation",
            "Positive periodic solution",
            "Existence",
            "Fixed point index"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Linghong Lu",
                "org": "Department of Mathematics, Yunnan University Kunming, Yunnan 650091, People's Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2005
    },
    "qUSjoqTl": {
        "id": "qUSjoqTl",
        "title": "Existence and global exponential stability of periodic solution of a class of neural networks with impulses",
        "abstract": "Sufficient conditions are obtained for the existence and global exponential stability of a unique periodic solution of a class of neural networks with variable and unbounded delays and impulses by using Mawhin’s continuation theorem of coincidence degree theory and by constructing Lyapunov functions.",
        "keywords": [
            "lyapunov function",
            "neural network"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +86 8715033701; fax: +86 8715147713."
            },
            {
                "name": "Wenya Xing",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            },
            {
                "name": "Linghong Lu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Chaos, Solitons & Fractals",
        "year": 2006
    },
    "V1ldrF6F": {
        "id": "V1ldrF6F",
        "title": "Existence of positive periodic solution of a periodic cooperativemodel with delays and impulses",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongkun li",
                "org": ""
            },
            {
                "name": "wenya xing",
                "org": ""
            }
        ],
        "venue": "International Journal of Mathematics and Mathematical Sciences",
        "year": 2006
    },
    "4qkmFEYv": {
        "id": "4qkmFEYv",
        "title": "Existence of periodic solutions in n-species food-chain system with impulsive",
        "abstract": "A delayed periodic n-species simple food-chain system with Holling-type III functional response and impulsive is investigated. By means of Gaines and Mawhin's continuation theorem of coincidence degree theory sufficient conditions are obtained for the existence of positive periodic solutions of the system.",
        "keywords": [
            "Positive periodic solution",
            "Impulsive",
            "Holling-type III functional response",
            "Coincidence degree theory"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author. Tel.: +868715033701; fax: +868715032576."
            },
            {
                "name": "Linghong Lu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            },
            {
                "name": "Xianyang Zhu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2006
    },
    "kVh9eKhT": {
        "id": "kVh9eKhT",
        "title": "Existence of positive solutions of p-Laplacian difference equations",
        "abstract": "Sufficient conditions are obtained that guarantee the existence of at least two positive solutions for the p-Laplacian difference equation △[ϕp(△u(t−1))]+a(t)f(u(t))=0 subject to boundary conditions by a simple application of a new fixed point theorem due to Avery and Henderson.",
        "keywords": [
            "p-Laplacian",
            "Boundary value problem",
            "Positive solution"
        ],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": "Corresponding author."
            },
            {
                "name": "Linghong Lu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematics Letters",
        "year": 2006
    },
    "yAhMh3RB": {
        "id": "yAhMh3RB",
        "title": "Existence of positive periodic solution of a periodic cooperative model with delays and impulses",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yongkun Li",
                "org": ""
            },
            {
                "name": "Wenya Xing",
                "org": ""
            }
        ],
        "venue": "Int. J. Math. Mathematical Sciences",
        "year": 2006
    },
    "QtEX2l2L": {
        "id": "QtEX2l2L",
        "title": "Existence of positive solutions of pp-Laplacian difference equations ☆",
        "abstract": "Sufficient conditions are obtained that guarantee the existence of at least two positive solutions for the p-Laplacian difference equation △[ϕp(△u(t−1))]+a(t)f(u(t))=0 subject to boundary conditions by a simple application of a new fixed point theorem due to Avery and Henderson.",
        "keywords": [
            "p-Laplacian",
            "Boundary value problem",
            "Positive solution"
        ],
        "authors": [
            {
                "name": "yongkun li",
                "org": "Corresponding author."
            },
            {
                "name": "linghong lu",
                "org": "Department of Mathematics, Yunnan University, Kunming, Yunnan 650091, People’s Republic of China"
            }
        ],
        "venue": "Applied Mathematics Letters",
        "year": 2006
    },
    "0dKr1BwT": {
        "id": "0dKr1BwT",
        "title": "Soil heavy metal sources identification and associated risk assessment using multivariate statistical and Fourier spectral analysis",
        "abstract": "In the Shunde Area of Foshan,Pearl River Delta Economic Zone,208 topsoil samples were collected from vegetable fields to measure the contents of copper,nickel,chromium,arsenic,lead,zinc,cadmium,and mercury. The results showed that the average concentration of all these eight heavy metals were higher than their background values of Guangdong Province. Coefficients of variation of Cd and Hg reached as high as 115% and 151% respectively,coupling with high concentrations,which suggested anthropogenic sources of these elements. Cr,Ni and Cu displayed low coefficients of variation,thus suggesting a major natural source. The combination of multivariate statistical and Fourier spectral analysis methods successfully identified the elements Pb,Zn,As,Cd and Hg from anthropogenic sources and Cr,Ni and Cu from natural source. Furthermore,Fourier spectral analysis not only interpreted the double sources of Zn and Cu,but also inferred that atmosphere deposition could be an important source of Hg enrichment in soil. According to the pollution evaluation,21.7 percent of the study area is suffered from moderate and severe pollution,indicating the requirement of modifications in agricultural cultivation practices in these areas.",
        "keywords": [
            "multivariate statistics",
            "Pearl River Delta Economic Zone",
            "heavy metal",
            "Fourier spectral analysis"
        ],
        "authors": [
            {
                "name": "Li Yong",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,China;Guangdong Provincial Key Lab of Geological Process and Mineral Resource Survey,Guangzhou ,China;Center for Earth Environment and Resources,Sun Yat-Sen University,Guangzhou ,China Earth Science Frontiers,2010,17%%#"
            },
            {
                "name": "Zhou Yongzhang",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,China;Guangdong Provincial Key Lab of Geological Process and Mineral Resource Survey,Guangzhou ,China;Center for Earth Environment and Resources,Sun Yat-Sen University,Guangzhou ,China Earth Science Frontiers,2010,17%%#"
            },
            {
                "name": "Dou Lei",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,China"
            },
            {
                "name": "Du Haiyan",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,China"
            },
            {
                "name": "Lai Qihong",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,China"
            },
            {
                "name": "Lin Xiaoming",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,China"
            },
            {
                "name": "Fan Rui",
                "org": "Guangdong Center of Environmental Technology,Guangzhou ,China;Center for Earth Environment and Resources,Sun Yat-Sen University,Guangzhou ,China Earth Science Frontiers,2010,17%%#"
            },
            {
                "name": "Du Min",
                "org": "%%#:253-261;Center for Earth Environment and Resources,Sun Yat-Sen University,Guangzhou ,China Earth Science Frontiers,2010,17%%#"
            }
        ],
        "venue": "Earth Science Frontiers",
        "year": 2010
    },
    "FPItyBa1": {
        "id": "FPItyBa1",
        "title": "Prediction and early-warning for health safety of lead in soil and vegetable system,the Pearl River Delta Plain,southern China",
        "abstract": "In Shunde District of Foshan City,Pearl River Delta Economic Zone,208 topsoil samples and 114 vegetable samples were collected from vegetable fields to measure the contents of lead (Pb) ,which species of 38 topsoil samples were extracted.The results showed that the average concentration of heavy metal Pb was 44.3mg/kg.The contents of soil lead that exceeded Guangdong Province soil background values accounted for 77.5%,,the content of lead in vegetable that exceeded safety requirements for non-en-vironmental pollution vegetable accounted for 74.6%.The accumulation tendency of soil Pb of study area in the future 10 years was predicted based on the accumulation rate of soil Pb in 2007 which equaled to 1.02mg/kg.Early-warning for the accumulation tendency of soil Pb were done based on the threshold values 150、270、300 and 8580mg/kg,respectively.The scale which soil Pb in excess of 150mg/kg was increased during 2007-2017 years,however,the scales were increased,which soil Pb in excess of 270、300mg/ kg,respectively.There was a significant relation between the transfer factor values and the corresponding soil Pb concentrations (full dosage or bioavailable amount),which can be described by a plateau model.The target hazard quotients (THQs) can be used to evaluate the health risks with heavy metals by consuming vegetable.The THQs of Pb in vegetables were below 0.4 that values from large to small were THQhigh>THQurban >THQmedian> THQrural>THQlow,which indicated that the health risk via vegetable consumption in the high levels of family economic income was the highest.Moreover,further researches about influence of Pb on the human health through other exposure paths should be done.",
        "keywords": [
            "Concentration factor",
            "Health risk",
            "Lead",
            "Pearl River Delta Plain",
            "Prediction and early-warning",
            "THQ"
        ],
        "authors": [
            {
                "name": "LI Yong",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,Guangdong,China;Guangdong Provincial Key Lab.of Geological Process and Mineral Resource Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "ZHOU Yong-zhang",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,Guangdong,China;Guangdong Provincial Key Lab.of Geological Process and Mineral Resource Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "DOU Lei",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "HUANG Yu-hui",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LAI Qi-hong",
                "org": "Guangdong Institute of Geological Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "FAN Rui",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,Guangdong,China;Guangdong Center of Environmental Technology,Guangzhou ,Guangdong,China"
            },
            {
                "name": "DU Min",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,Guangdong,China;Zhongshan Environmental Protection Bureau,Zhongshan ,Guangdong,China"
            },
            {
                "name": "HE Xiang",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,Guangdong,China;Guangdong Provincial Key Lab.of Geological Process and Mineral Resource Survey,Guangzhou ,Guangdong,China"
            },
            {
                "name": "WEI Zhi-chao",
                "org": "Department of Earth Science,Sun Yat-Sen University,Guangzhou ,Guangdong,China;Guangdong Provincial Key Lab.of Geological Process and Mineral Resource Survey,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2010
    },
    "v4bfROT2": {
        "id": "v4bfROT2",
        "title": "A Study of Prediction and Early-Warning Forecast on Geochemical Accumulation of Soil Heavy Metals Based on Flux Model in Pearl River Delta Economic Zone(China)",
        "abstract": "The Pearl River Delta Economic Zone(PRDEZ) is one of the most developed areas economically and socially in China,and its eco-geochemical environment is heavily affected by human activities.In this paper,net flux of soil heavy metals is estimated on regional input-output flux model,and then prediction and early-warning forecast on geochemical accumulation of soil heavy metals is carried out.Early warning forecast is conducted by the factor pollution index obtained from the Probability Kriging model which integrates the space distribution and probability distribution of soil heavy metals.The concentration threshold for warning factor is taken from the China National Environmental Quality Standards for the level-II soil.It is shown that Cd,Hg,Ni and Cr are the main eco-geochemical warning factors for the paddy land soil,Cd,Hg and Ni factors for the dry land,and As,Cr and Ni for the garden land.With the present development model going until the year of 2025,the heavily warning regions of paddy land soil will extend to the Pengjiang District,Jianghai District and Xinhui District in Jiangmen City,Kaiping,Heshang,Zhongshan,Nansha Districts,Panyu District in Guangzhou City,Dinghu District,Duanzhou District and Gaoyao District in Zhaoqing City,and Doumen District in Zhuhai City.The heavily warning regions of dry land soil will extend to Panyu District,Nansha District,Baiyun District,Huangpu District,Luogang District and Huadu District in Gangzhou City,Gaoming District,Nanhai District,Shunde District and Shancheng District in Foshan City,Sihui District in Zhaoqing City,Xiaolan District,Guzhen District,Sanjiao District and Dongshen District in Zhongshan City,Doumen District and Jinwandeng District in Zhuhai City,and Xinhui,Kaiping and Taishan in Jiangmen City.The heavily warning regions of garden land soil will extend to Nansha District,Panyu District and Huadu District in Guangzhou City,the northern Huidong County in Huizhou City,Doumen District,Jinwan District and Tanzhou District in Zhuhai City,and Shunde District,Nanhai District,Shancheng District and Sanshui District in Foshan City.",
        "keywords": [
            "Eco-geochemically Early Warning Forecast",
            "Probability Kriging model",
            "Soil heavy metals",
            "Pearl River Delta Economic Zone.",
            "Regional input-output flux model"
        ],
        "authors": [
            {
                "name": "Zhou Yongzhang",
                "org": "Department of Earth Sciences,Sun Yat-Sen University,Guangzhou ,China;Research Center for Earth Environment and Resources,Guangzhou ,China;Guangdong Provincial Key Laboratory of Mineral Resource & Geological Processes %%#GDMine%%#,Guangzhou ,China"
            },
            {
                "name": "Shen Wenjie",
                "org": "Department of Earth Sciences,Sun Yat-Sen University,Guangzhou ,China;Research Center for Earth Environment and Resources,Guangzhou ,China;Guangdong Provincial Key Laboratory of Mineral Resource & Geological Processes %%#GDMine%%#,Guangzhou ,China"
            },
            {
                "name": "Li Yong",
                "org": "Department of Earth Sciences,Sun Yat-Sen University,Guangzhou ,China;Research Center for Earth Environment and Resources,Guangzhou ,China;Guangdong Provincial Key Laboratory of Mineral Resource & Geological Processes %%#GDMine%%#,Guangzhou ,China"
            },
            {
                "name": "Dou Lei",
                "org": "Guangdong Geological Survey,Guangzhou ,China;Research Center for Earth Environment and Resources,Guangzhou ,China"
            },
            {
                "name": "Li Wensheng",
                "org": "Guangdong Geological Survey,Guangzhou ,China"
            },
            {
                "name": "Lai Qihong",
                "org": "Guangdong Geological Survey,Guangzhou ,China;Foshan Bureau of Geology, Foshan ,China"
            },
            {
                "name": "Du Haiyan",
                "org": "Guangdong Geological Survey,Guangzhou ,China"
            },
            {
                "name": "Zhong Lili",
                "org": "Department of Earth Sciences,Sun Yat-Sen University,Guangzhou ,China;Guangdong Provincial Key Laboratory of Mineral Resource & Geological Processes %%#GDMine%%#,Guangzhou ,China"
            },
            {
                "name": "Liang Ting",
                "org": "Department of Earth Sciences,Sun Yat-Sen University,Guangzhou ,China;Guangdong Provincial Key Laboratory of Mineral Resource & Geological Processes %%#GDMine%%#,Guangzhou ,China"
            }
        ],
        "venue": "Advances in Earth Science",
        "year": 2012
    },
    "EsvxDSYF": {
        "id": "EsvxDSYF",
        "title": "Distributional characteristics and sources of elements in soil from typical area of Pearl River Delta economic zone, Guangdong Province, China",
        "abstract": "Dongguan City, located in the Pearl River Delta economic zone of China, is famous for its rapid developing township-enterprises in the past 30 years. A total of 759 composite soil samples, including 606 surface soil samples and 153 deep soil samples, have been collected in the city. These samples have been analyzed for 13 elements (Al, As, Cu, Cd, Co, Cr, Fe, Hg, Mn, Ni, Pb, Si, and Zn) and other parameters (pH values and organic matter) to evaluate the influence of anthropic activities on the soil environmental quality and to identify the spatial distribution of heavy metals and their possible sources. The results indicate that the average concentrations of heavy metals in soil were significantly lower than the threshold of the second grade of the Soil Environment Quality Standard in China (GB15618-1995) and the soil environmental quality in this area is comparatively good. But in comparison with local soil geochemical baseline values, As, Cd, Cu, Hg, Pb, and Zn have accumulated remarkably. Specifically, the average concentrations of As, Cd, Cu, and Hg in the small part samples of the west plain and central areas are higher than the national second-grade quality standard, indicating some level of contamination. Multivariate and geostatistical methods have been applied to differentiate the influences of natural processes and human activities on the concentration of heavy metals in surface soils in the study area. Cluster and factor analyses result in the grouping of Al, As, Cr, Cu, Fe, Ni, and Si into factor F1; Co, Mn, Pb, and Zn into F2; and Cd and Hg into F3. The spatial pattern of the three factors may be well demonstrated by geostatistical analysis. It is shown that the first factor could be considered as a natural source controlled by parent material. The second factor could be referred to as “industrial and traffic pollution sources”. The source of the third factor is mainly controlled by long-term anthropic activities, including agricultural activities, fossil fuel consumption, and atmospheric deposition.",
        "keywords": [
            "Heavy metals",
            " Distributional characteristics",
            " Source",
            " Multivariate statistics",
            " Geostatistics",
            " Typical intensive area of township-enterprises",
            " Pearl River Delta economic zone"
        ],
        "authors": [
            {
                "name": "lei dou",
                "org": "Geological Survey of Guangdong Province,Guangzhou,China"
            },
            {
                "name": "shuzhen shen",
                "org": "beijing normal university"
            },
            {
                "name": "haiyan du",
                "org": "Geological Survey of Guangdong Province,Guangzhou,China"
            }
        ],
        "venue": "Chinese Journal of Geochemistry",
        "year": 2015
    },
    "Jj09LAcm": {
        "id": "Jj09LAcm",
        "title": "The Spatial Structure and Distribution of Cr Contents in Agricultural Soils in a Typical Area of the Pearl River Delta, China",
        "abstract": "Spatial variability and distribution of Cr contents in agricultural soils of Dongguan city, Guangdong Province are studied using geo- statistics and geographic information system(GIS)techniques. 118 surface samples and 5 vertical sections of agricultural soil were collected from Dongguan city. Spatial structure is described with Variogram. The results show that Cr contents are 2.28～94.98 mg·kg-1 in agricultural soils of Dongguan, the mean content is 44.90 mg·kg-1, and higher slightly than the soil background value of Dongguan. Well-defined struc- ture with nonzero nugget effect, distinct sill and range can be fitted with exponential model (R2=0.78, P<0.01), which is mostly influenced by soil parent materials and landform, the relative range is 18.3 km. Variogram analysis shows that spatial structure of Cr contents has obvious geometric anisotropy whose ratio is 1.8. The major axis is in northwestern 13° direction in which there is the longest range. The spatial distri- bution of Cr contents shows that Cr contents of agricultural soils are high in west and low in east, which is mostly controlled by soil parent ma- terials and landform, is influenced strongly by anthropogenic factors.",
        "keywords": [
            "Dongguan",
            "Cr",
            "agricultural soil",
            "geostatistics",
            "variogram"
        ],
        "authors": [
            {
                "name": "CAI Li-mei",
                "org": " Department of Earth Science, Sun Yat-sen University, Guangzhou , China; Center for Earth Environment and Resources, Sun Yat-sen University, Guangzhou , China; Geological Investigation Institute of Guangdong Province, Guangzhou , China"
            },
            {
                "name": "HUANG Lan-chun",
                "org": " Department of Earth Science, Sun Yat-sen University, Guangzhou , China; Center for Earth Environment and Resources, Sun Yat-sen University, Guangzhou , China"
            },
            {
                "name": "ZHOU Yong-zhang",
                "org": " Department of Earth Science, Sun Yat-sen University, Guangzhou , China; Center for Earth Environment and Resources, Sun Yat-sen University, Guangzhou , China"
            },
            {
                "name": "MA Jin",
                "org": " Department of Earth Science, Sun Yat-sen University, Guangzhou , China; Center for Earth Environment and Resources, Sun Yat-sen University, Guangzhou , China"
            },
            {
                "name": "DU Hai-yan",
                "org": " Geological Investigation Institute of Guangdong Province, Guangzhou , China"
            },
            {
                "name": "DOU Lei",
                "org": " Department of Earth Science, Sun Yat-sen University, Guangzhou , China; Center for Earth Environment and Resources, Sun Yat-sen University, Guangzhou , China"
            },
            {
                "name": "ZHANG Cheng-bo",
                "org": " Department of Earth Science, Sun Yat-sen University, Guangzhou , China; Center for Earth Environment and Resources, Sun Yat-sen University, Guangzhou , China"
            }
        ],
        "venue": "Journal of Agro-Environment Science",
        "year": 2009
    },
    "JSMxxWxr": {
        "id": "JSMxxWxr",
        "title": "Elementary Research of Organochlorine Pesticide in Groundwater of Pearl River Delta",
        "abstract": "In order to find out the distribution characteristics of organochlorine pesticides in groundwater in the Pearl River Delta, 10 groups of groundwater samples from the Pearl River Delta region were tested with gas chromatography.The result shows there are varieties of organochlorine pesticides existing and widely distributing in groundwater of the Pearl River Delta Region, but their concentration is generally low.On the whole, as far as distribution range is concerned, pollutants of HCHs kind are the widest, next are other pollutants(pollutants other than HCHs and DDTs in this paper), pollutants of DDTs kind are the smallest.As far as concentration is concerned, other pollutants are the highest, next is HCHs kind, DDTs kind is the lowest.In addition, by comparing organochlorine pesticides in groundwater of Suzhou, Wuxi and Changzhou to that of Bangladesh in 1995, the conclusion is achieved:an early ban of organochlorine pesticides is one of the important factors leading to the low concentration of organochlorine pesticides in groundwater of the Pearl River Delta region.Altogether, although organochlorine pesticides pollution is not severe in groundwater in Pearl River Delta region, given organochlorine pollutants' difficult degradation and that its harm could be magnified by gradual accumulation in organism, attention must be paid to pollution trend of organochlorine pesticides, the area severely polluted must be protected and managed.",
        "keywords": [
            "groundwater",
            "Pearl River Delta",
            "organochlorine pesticides",
            "distribution characteristic"
        ],
        "authors": [
            {
                "name": "HUANG Guan-xing",
                "org": "Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang ,China"
            },
            {
                "name": "SUN Ji-chao",
                "org": "Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang ,China"
            },
            {
                "name": "WANG Shan",
                "org": "Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Guangdong Institute of Geological Survey, Guangzhou ,China"
            },
            {
                "name": "LU Yao-dong",
                "org": "No.1 Team of Hydrogeology and Engineering Geology of Guangdong Bureau of Geological Exploration, Zhanjiang ,China"
            },
            {
                "name": "ZHI Bing-fa",
                "org": "Guangdong Institute of Geological Survey, Guangzhou ,China"
            },
            {
                "name": "CHEN Hui-chuan",
                "org": "Guangdong Institute of Geological Survey, Guangzhou ,China"
            },
            {
                "name": "CHEN Xi",
                "org": "Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang ,China"
            },
            {
                "name": "JING Ji-hong",
                "org": "Institute of Hydrogeology and Environmental Geology, Chinese Academy of Geological Sciences, Shijiazhuang ,China"
            }
        ],
        "venue": "Journal of Agro-Environment Science",
        "year": 2008
    },
    "nPzJ4OBC": {
        "id": "nPzJ4OBC",
        "title": "Fluorine Accumulation in Vegetables and Paddies of Southern Hanjiang Delta, Guangdong Province (China)",
        "abstract": "Fluorine contents were determined in 46 vegetables and 8 paddies, and most of them in the vegetables did not exceed the national hygienic standard(1.0 mg·kg-1). The accumulation of fluorine showed great differences among different vegetable types, and mustard had the highest fluorine concentration in all vegetables determined. But all paddies determined exceeded the national hygienic standard seriously, with the average and highest fluorine content was 22.85 mg·kg-1 and 31 mg·kg-1 respectively. Fluorine concentrations in 115 soil samples were determined, and 46% exceeded the national standard. The water-soluble fluorine content varied with the soil characters, and led to high fluorine content in paddies and low fluorine content in vegetables. And fluorine concentration in all 22 irrigated water samples determined were 0.17~0.68 mg·kg-1, and did not exceed 2.0 mg·kg-1 of the national irrigated water standard. Combined with some scholar′s study that fluorine content in drinking water did not exceed the national hygienic standard, it was found that there were some relations between high fluorine content in paddies and epidemic fluorosis.",
        "keywords": [
            "fluorine",
            "epidemic fluorosis",
            "paddy",
            "Hanjiang delta",
            "vegetable"
        ],
        "authors": [
            {
                "name": "MA Jin",
                "org": "Center for Earth Environment & Resources, Zhongshan University, Guangzhou , China; Department of Earth Science, Zhongshan University, Guangzhou , China"
            },
            {
                "name": "ZHOU Yong-zhang",
                "org": "Center for Earth Environment & Resources, Zhongshan University, Guangzhou , China; Department of Earth Science, Zhongshan University, Guangzhou , China"
            },
            {
                "name": "DOU Lei",
                "org": "Center for Earth Environment & Resources, Zhongshan University, Guangzhou , China; Department of Earth Science, Zhongshan University, Guangzhou , China"
            },
            {
                "name": "DU Hai-yan",
                "org": " Guangdong Geological Survey, Guangzhou , China"
            },
            {
                "name": "LAI Qi-hong",
                "org": " Guangdong Geological Survey, Guangzhou , China"
            },
            {
                "name": "ZHANG Cheng-bo",
                "org": "Center for Earth Environment & Resources, Zhongshan University, Guangzhou , China; Department of Earth Science, Zhongshan University, Guangzhou , China"
            }
        ],
        "venue": "Journal of Agro-Environment Science",
        "year": 2008
    },
    "2QfcLVBI": {
        "id": "2QfcLVBI",
        "title": "Microstructure and properties of inter-locked mullite framework prepared by the TBA-based gel-casting process",
        "abstract": "Abstract   Inter-locked mullite frameworks (IM frameworks) were prepared by the tert butyl alcohol (TBA) -based gel-casting method. The inter-locked structure formed through fluorine-catalyzed gas-phase reaction. Inter-locked topaz structure first formed in the samples and then it transformed into inter-locked mullite structure. TBAu0027s volatilization and gaseous reactantsu0027 running off, which acted as two kinds of “pore formers” in the gel-casting process, offered enough space for the mullite grainsu0027 anisotropic growth, and led to the porous structureu0027s formation. The volume density, apparent porosity, specific surface area and compression strength of the samples that formed at 1100–1500 °C were found to be 0.53–0.59 g/cm 3 , 82.1–76.1%, 12.3–4.6 m 2 /g and 1.6–3.6 MPa, respectively, indicating that the IM frameworks are promising as high-temperature catalyst supports.",
        "keywords": "",
        "authors": [
            {
                "name": "Shan Liu",
                "org": "School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering of Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Feng Hou",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering of Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering of Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2016
    },
    "L3lYbJ6X": {
        "id": "L3lYbJ6X",
        "title": "Direct Joining of Al_2O_3 and ZrO_2 in Plastic Green State",
        "abstract": "Al_2O_3 and 3% (mole fraction) yttrium tetragonal zirconia was joined together by a process of directly joining their green body in plastic state and following co-sintering. Joining strength, joint microstructure, stress state of joining interface, and diffusion between joined compositions were studied. Experimental results show that a transition interlayer containing both joined particles is formed in the joint which is dense and pore free, fracture taken place at Al_2O_3 matrix near the joining interface but the joining strength is lower than normal Al_2O_3 matrix because of the complex stress state near the interface. Apart from the effect of plasticity of green bulk on joining before sintering, it is postulated from the HRTEM/EDS studied results that the diffusion of Al 3+ to the ZrO_2 grain during the sintering process contributed to the interface bonding which led a success joining of Al_2O_3 and ZrO_2 composites.",
        "keywords": [
            "interface(B)",
            "strength(B)",
            "joining(E)",
            "fracture(B)"
        ],
        "authors": [
            {
                "name": "Tian Boran",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Liu Jiachen",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Liu Libin",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Wang Miao",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Du Haiyan",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2005
    },
    "dYAquEpS": {
        "id": "dYAquEpS",
        "title": "Effects of Characteristics of Fly Ash on the Properties of Geopolymer",
        "abstract": "The properties of two types of fly ash geopolymers made from class F fly ashes produced in wet bottom and dry bottom boilers were investigated in the present study. The source material used in the geopolymer concrete was activated with sodium hydroxide and sodium silicate solution. The results revealed that the geopolymer produced with wet bottom boiler fly ash(CZ-FA)hardened quickly, and had higher early-age strength and lower shrinkage than the geopolymer produced with dry bottom boiler fly ash(SX-FA). The compressive strength of the two geopolymers made from CZ-FA and SX-FA was 45 MPa and 15 MPa respectively when cured at 60 °C and delayed for 14 d. However, after 90 days’ delay, the compressive strength of both the samples is almost the same, up to 80 MPa. Nearly 20% volume shrinkage of the samples made from SX-FA was much higher than that made from CZ-FA, which was almost zero. XRD, SEM/EDS and FT-IR were used to analyze the main reason of the differences.",
        "keywords": [
            "geopolymer",
            " class F fly ash",
            " calcium",
            " compressive strength"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, China"
            },
            {
                "name": "Lina Yang",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, China"
            },
            {
                "name": "Wanqi Gao",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, China"
            }
        ],
        "venue": "Transactions of Tianjin University",
        "year": 2016
    },
    "JJKTc5hv": {
        "id": "JJKTc5hv",
        "title": "Highly efficient Pt/TiO2Pt/TiO2 photocatalyst for hydrogen generation prepared by a cold plasma method",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ji-Jun Zou",
                "org": ""
            },
            {
                "name": "Hei He",
                "org": ""
            },
            {
                "name": "Lan Cui",
                "org": ""
            },
            {
                "name": "Hai-Yan Du",
                "org": ""
            }
        ],
        "venue": "International Journal of Hydrogen Energy",
        "year": 2007
    },
    "UdATwgod": {
        "id": "UdATwgod",
        "title": "Lightweight alumina based fibrous ceramics with different high temperature binder",
        "abstract": "Abstract   In this study, two kinds of alumina based fibrous ceramics, conventional alumina fibrous ceramics and the designed alumina/silica composite fibrous ceramic, were fabricated with different high temperature binders and the effect of the kind of high temperature binder and the binder content on the sample properties were analyzed. Furthermore, comparative analyses of the microstructure and compression and rebound properties of two kinds of alumina based fibrous ceramics were conducted. Conventional alumina fibrous ceramics were fabricated with the silica sol as the high temperature binder and the introduction of silica sol endow the sample a high compressive strength; however, the introduced silica phase would fill the pores constructed by the alumina fibers, consequently increasing the sample porosity. The alumina/silica composite fibrous ceramics were fabricated with glass fibers as the high temperature binder. The alumina fibers lapped with each other and acted as the main matrix of structure, while the molten silica binders bonded the junction of matrix fibers. Therefore, the high temperature binder would not influence the sample porous structure. The alumina/silica composite fibrous ceramic exhibited a higher compression and rebound ratio than the alumina fibrous ceramic due to its excellent skeletal structure.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenjie Zang",
                "org": "School of Material Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Feng Guo",
                "org": "School of Material Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Material Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Material Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Feng Hou",
                "org": "School of Material Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Material Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2016
    },
    "iSnbHnNF": {
        "id": "iSnbHnNF",
        "title": "Microstructure characterization of in situ synthesized porous Si 2 N 2 O ceramics using spodumene additive",
        "abstract": "",
        "keywords": [
            "ceramics",
            "fibers"
        ],
        "authors": [
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "mengxia liu",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "0YvDf6sW": {
        "id": "0YvDf6sW",
        "title": "Effects of in situ synthesized mullite whiskers on compressive strength of mullite fiber brick",
        "abstract": "Abstract   The method of in situ synthesis of mullite whiskers by gas-phase deposition and reaction was applied to improve the compressive strength of the mullite fiber brick. During the preparation process, silica sol, Al(NO 3 ) 3  solution and NH 4 F solution were introduced into the fibrous brick in the form of ions or sol through vacuum impregnation and freeze drying, and the silica sol, Al(NO 3 ) 3  and NH 4 F served as the silica sources, aluminum source and catalyst, respectively. Effects of process parameters (concentration of impregnation solutions, holding time, sintering temperature) on compressive strength and elastic modulus of the fibrous brick during the in situ toughening process were analyzed. SEM and XRD analysis results demonstrated that the mullite whiskers were synthesized on the surface of mullite fibers based on the reaction of AlOF and SiF 4 . What is more, the whiskers on adjacent fibers intersected with each other and formed many unfixed lap-jointing points, resulting in the increase of compressive strength and elastic modulus. Although the density and thermal conductivity of the sample after the generation of mullite whiskers fabricated with the optimum process were 0.406 g/cm 3  and 0.1262 W/(m K), respectively, which were slightly higher than that of the raw fibrous brick (0.375 g/cm 3  density and 0.1069 W/(m K) thermal conductivity, respectively), the corresponding compressive strength and elastic modulus of the sample reinforced with the whiskers increased to 1.45 MPa and 42.03 MPa, respectively, which were much higher than that of the raw fibrous brick (0.39 MPa compressive strength and 6.5 MPa elastic modulus).",
        "keywords": "",
        "authors": [
            {
                "name": "Xin Wang",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiapeng Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Yuanyuan Wang",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Feng Hou",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2016
    },
    "HONQKlSf": {
        "id": "HONQKlSf",
        "title": "Improved electrochemical performance of Li[LiMnNiCo]O by doping with molybdenum for Lithium battery",
        "abstract": "The Li[LiMnNiCo]O materials doped with different Mo content were studied using electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDX), and X-ray diffractometry (XRD). The electrochemical properties were also measured. An increase of Mo content resulted in a bigger lattice volume and a lower cation disorder. In addition, the electrochemical performance was enhanced with the increasing Mo content. However, more aggregation of particles was found to occur at a higher Mo content, which resulted in worse electrochemical performance. The highest electrochemical performance was obtained with a 5 mol% Mo addition.",
        "keywords": [
            "Cathode materials",
            "Structure",
            "Mo",
            "Capacity"
        ],
        "authors": [
            {
                "name": "Jiangyong Du",
                "org": "School of Chemical Engineering and Technology,Tianjin University,Tianjin,People’s Republic of China"
            },
            {
                "name": "Zhongqiang Shan",
                "org": "School of Chemical Engineering and Technology,Tianjin University,Tianjin,People’s Republic of China"
            },
            {
                "name": "Kunlei Zhu",
                "org": "School of Chemical Engineering and Technology,Tianjin University,Tianjin,People’s Republic of China"
            },
            {
                "name": "Xiaoyan Liu",
                "org": "School of Chemical Engineering and Technology,Tianjin University,Tianjin,People’s Republic of China"
            },
            {
                "name": "Jianhua Tian",
                "org": "School of Chemical Engineering and Technology,Tianjin University,Tianjin,People’s Republic of China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education,School of Materials Science and Engineering of Tianjin University,Tianjin,People’s Republic of China"
            }
        ],
        "venue": "Journal of Solid State Electrochemistry",
        "year": 2015
    },
    "KOFdgSMc": {
        "id": "KOFdgSMc",
        "title": "Synthesis and properties of lightweight flexible insulant composites with a mullite fiber-based hierarchical heterostructure",
        "abstract": "",
        "keywords": [
            "sol gel",
            "microstructure",
            "thermal conductivity",
            "fibers"
        ],
        "authors": [
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "guofa sui",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            }
        ],
        "venue": "Chemical Engineering Journal",
        "year": 2015
    },
    "iFW2TKUY": {
        "id": "iFW2TKUY",
        "title": "Study on phase equilibrium of Al2O3-ZrO2-SiO2 system by microwave treating",
        "abstract": "Based on Al2O3-ZrO2-SiO2 ternary system, representative samples were selected to be pretreated in the conventional furnace, and then the microwave samples were heated by microwave. The effects of microwave heating on the changes of phases with different power and holding time were studied. It was concluded that microwave heating can promote equilibrium of phase effectively.",
        "keywords": [
            "Al2O3-ZrO2-SiO2 equilibrium of phase",
            "Microwave"
        ],
        "authors": [
            {
                "name": "Chao Chen",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Pengyu Zhang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Wei Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Yadian Yu Shengguang/Piezoelectrics and Acoustooptics",
        "year": 2008
    },
    "GVJraINI": {
        "id": "GVJraINI",
        "title": "Joining of various engineering ceramics and composites by a modified preceramic polymer for high-temperature application",
        "abstract": "",
        "keywords": [
            "fracture",
            "heat treatment",
            "composite",
            "ceramics"
        ],
        "authors": [
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "xin tao",
                "org": ""
            },
            {
                "name": "manman liu",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2015
    },
    "zWScCmOU": {
        "id": "zWScCmOU",
        "title": "Preparation of MoSi2-SiC-Al2O3-SiO2 Coating on Mullite Fibrous Insulation with Silica Sol as Binder by Non-Firing Process",
        "abstract": "Abstract   High-emissivity MoSi 2 -SiC-Al 2 O 3 -SiO 2  coating with MoSi 2  and SiC as emittance agents, Al 2 O 3  as base skeleton, and silica sol as both dispersive medium of the coating slurry and binder of the coating, was prepared on mullite fibrous insulations via slurry coating and non-firing process. The non-firing coatings were calcined at high temperatures to reveal their reusability after high temperature service. Microstructure, phase composition, interface bonding strength and impact resistance of the non-firing coating and the calcined coatings were investigated comprehensively. Thermal shock resistance, thermal endurance and infrared radiation property of the coatings were studied. The results show that the non-firing coating was dense and flat with all particles bonded together by silica sol; no clear interface existed between the coating and the substrate due to the penetration of the coating slurry; the whole coating was composed of a porous inner layer of about 300 µm in thickness and a top layer of about 100 µm in thickness. The calcined coatings exhibited ideal microstructure with newly formed high temperature phases. Both interface bonding strength and impact resistance of the calcined coatings increased with elevated calcination temperatures, benefited from the good binding effect of silica sol, the gradient structure and the formation of mullite. The coatings remained intact without peeling and spalling after thermal shock tests, and the main defects in the coating surface after thermal shock tests at 1400 °C and 1500 °C were cracks and holes, respectively. The coatings exhibited better long-term thermal endurance at 1400 °C than at 1500 °C, resulted from the weaker oxidation of emittance agents at lower temperature. The emissivity of the non-firing coating at the wavelength range of 3–5 µm and 8–12 µm was as high as 0.9, benefited from the non-firing process, and the emissivity of the calcined coatings were higher than 0.8.",
        "keywords": "",
        "authors": [
            {
                "name": "Linlin Guo",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Xin Tao",
                "org": ""
            },
            {
                "name": "Zheng Gong",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2018
    },
    "ySvZBSN3": {
        "id": "ySvZBSN3",
        "title": "Growth and characterization of CuInSe2 thin films prepared by successive ionic layer adsorption and reaction method with different deposition temperatures",
        "abstract": "CuInSe 2 films were prepared at different deposition temperatures ( T D ) by successive ionic layer adsorption and reaction method with chelating solutions. Influence of T D on film growth, morphology, crystal structure, and band gap energy was investigated. Results showed that elevation of T D mainly enhanced reaction kinetics and ionic diffusion velocity, resulting in fast growth rate of CuInSe 2 films, and maximum 20–30 nm/cycle depended upon T D were acquired. Films with 60 dip-cycles could grow from 180 nm to 1000 nm by elevating T D from 30 °C to 90 °C. Surface roughness of CuInSe 2 films was closely related to dip-cycle times and T D . Accelerated growth rate by T D could reduce the dip-cycle times for a required film thickness, which improved quality of film morphology.",
        "keywords": [
            "Deposition temperature",
            "Film growth",
            "CuInSe 2",
            "Successive ionic layer adsorption and reaction (SILAR)"
        ],
        "authors": [
            {
                "name": "Jingxia Yang",
                "org": "Key Laboratory For Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Zhengguo Jin",
                "org": ""
            },
            {
                "name": "Yating Chai",
                "org": "Key Laboratory For Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory For Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Tongjun Liu",
                "org": "Key Laboratory For Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Tao Wang",
                "org": "Key Laboratory For Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin, 300072, China"
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2009
    },
    "umyj7Qud": {
        "id": "umyj7Qud",
        "title": "Joining of silicon carbide by a heat-resistant phosphate adhesive",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mingchao wang",
                "org": "tianjin university"
            },
            {
                "name": "jiachen liu",
                "org": "tianjin university"
            },
            {
                "name": "haiyan du",
                "org": "tianjin university"
            },
            {
                "name": "feng hou",
                "org": "tianjin university"
            },
            {
                "name": "anran guo",
                "org": "tianjin university"
            },
            {
                "name": "yingna zhao",
                "org": "tianjin university"
            },
            {
                "name": "jing zhang",
                "org": "tianjin university"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "U6ODbDov": {
        "id": "U6ODbDov",
        "title": "Effects of adhesive composition on bond strength of green joined CePO 4 –ZrO 2 ceramics",
        "abstract": "",
        "keywords": [
            "bond strength",
            "joint",
            "interface",
            "microstructures",
            "slurries"
        ],
        "authors": [
            {
                "name": "hai gao",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "mingzheng liu",
                "org": ""
            },
            {
                "name": "weirong huo",
                "org": ""
            },
            {
                "name": "lijuan wang",
                "org": ""
            }
        ],
        "venue": "Scripta Materialia",
        "year": 2003
    },
    "qzGExOSF": {
        "id": "qzGExOSF",
        "title": "Microstructure, mechanical properties and thermal shock resistance of ZrO2–LaPO4 composites",
        "abstract": "4YSZ–LaPO 4 composites with different LaPO 4 content ranging from 0 to 30 vol.% were prepared. Influence of LaPO 4 content on the microstructure, mechanical properties and thermal shock resistance under mild thermal conditions of the composites were investigated. With the increased content of monazite LaPO 4 , Vickers hardness, flexural strength and fracture toughness of the 4YSZ–LaPO 4 composites exhibited a gradual degradation, while the thermal shock resistance was improved obviously. Results showed that the critical thermal shock temperature (Δ T c ) of 4YSZ/30 vol.% LaPO 4 composite under air quenching was 1400 °C, which was 400 °C higher than that of monolithic 4YSZ. Improvement of thermal shock resistance for 4YSZ–LaPO 4 composites was mainly due to the higher ratio value of K Ic / σ and the crack deflection and bridging at weak bonding interface between ZrO 2 and LaPO 4 . Keywords Ceramics Composites Mechanical properties Microstructure Scanning electron microscopy 1 Introduction Dense zirconia ceramics are materials with important technological applications due to their unique combination of excellent properties, such as strength, toughness, chemical stability, refractory characteristics and corrosion resistance [1–3] . However, the poor thermal shock resistance, resulting from the high thermal expansion coefficient and low thermal conductivity, largely limited their actual applications. Thermal shock resistance is a major issue for ceramics applied under high temperature environment. According to the classic theory on the thermal shock behavior of brittle ceramics established by Hasselman [4,5] , increased thermal shock resistance can be achieved either by making it more difficult for cracks to initiate or by limiting the extent to which they can grow once cracking has started. Obtaining useful improvements to the thermal shock resistance by preventing the initiation of cracks is difficult, particularly when the thermal shock is severe, as the crack driving forces can be many orders of magnitude greater than the resistance to fracture of ceramic materials. It is therefore more usual to try to limit the extent of crack propagation. This requires either that as much energy as possible be dissipated in growing the crack, or that the crack driving force available to each individual crack be reduced. In recent years, some literatures reported that the incorporation of a particulate second phase (e.g., molybdenum [6] , Fe 3 Al [7] , Al 2 TiO 5 [8] , h-BN [9] , AlN [10] and ZrB 2 [11] ) into dense zirconia matrix could lead to an enhanced thermal shock resistance. The improvement of thermal shock resistance was largely attributed to the crack shielding and blunting and crack deflection. While the composites have an improved thermal shock resistance, the usefulness of them is limited by their sensitivity to oxidation. Monazite LaPO 4 is a suitable and effective oxide interface material, which exhibits high stability at high temperature in both reducing and oxidizing environment and shows good chemical compatibility with ZrO 2 [12] . The ZrO 2 /LaPO 4 interface is weak enough to prevent crack growth by interfacial debonding and crack deflection [13] . Therefore, it is expected that the thermal shock resistance can be improved without compromising the excellent refractoriness of zirconia ceramics. In this paper, influence of LaPO 4 content on the thermal shock resistance of dense 4YSZ–LaPO 4 composites under mild thermal condition was investigated. 2 Experimental procedure Commercial available Y 2 O 3 (99%, Zibo rare earth material Co. Ltd., Shandong, China), ZrO 2 (99.5%, 0.5 μm, Fanmeiya powder Co. Ltd., Jiangxi, China) and LaPO 4 (99%, Zibo rare earth material Co. Ltd., Shandong, China) powders were used as the starting materials. The LaPO 4 powder was calcined at 1250 °C for 1 h. The mixtures of ZrO 2 , Y 2 O 3 and LaPO 4 were ball milled for 8 h using nylon pots with high purity zirconia balls, Y 2 O 3 –LaPO 4 ranging from 0 to 30 vol.%. The milled slurry was dried at 100 °C in a baking oven and then sieved through an 80 mesh. The dried powder mixture was uniaxially pressed at 200 MPa into rectangular green compacts (30 mm × 7 mm × 4 mm) and then cold isostatic pressed at 250 MPa. The green samples were pressureless-sintered in air at 1550 °C for 2 h according to our existing preparation conditions. Bulk density of the sintered specimens was measured by the Archimedes displacement method with distilled water, and the theoretical density was estimated by the rule of mixtures. Sintered specimens for flexural strength test were machined into bars with dimensions of 25 mm × 5 mm × 2.5 mm, and the top and bottom surfaces were ground flat and polished by standard diamond polishing techniques down to 1 μm. The edges of all the specimens were chamfered to minimize the effect of stress concentration due to machining flaws. The flexural strength of the specimens was tested using a conventional three point flexural method, with a span of 20 mm and a cross-head speed of 0.368 mm/min. Measurements were performed on at least five test bars of each material. Hardness (Hv) and fracture toughness ( K IC ) at room temperature were determined from Vickers indentation tests (HV-10 Vickers hardness tester) on polished surfaces with indentation loads of 98 and 196 N during times of 15 s, respectively. No chipping associated with any indentation was detected, and the indentations that exhibited secondary radial cracking were rejected. The principal diagonals of the plastically deformed zone and the length of the radial cracks were measured using the optical microscopy equipped on HV-10 Vickers hardness tester. The equation proposed by Niihara [14] was used to calculate the K IC . Reported Hv and K IC values are the average of ten determinations and errors are the standard deviations. The young's modulus and thermal expansion coefficient of ZrO 2 –LaPO 4 composites were calculated by Eq. (1) [15] : (1) E = E 1 V 1 + E 2 V 2 where subscripts 1 and 2 denote ZrO 2 and LaPO 4 , respectively. V is the volume fraction. The microstructures of sintered, polished and fractured specimens (after ultrasonic cleaning with acetone and dried) were examined using a Philips XL-30 scanning electron microscope (SEM). XRD analysis was carried out using Rigaku D/max 2500 v/pc X-ray diffractometer (Cu Kα, Ni filter). The volume fraction of the m -ZrO 2 ( V m ) was calculated by measuring the intensities of (1 1 1) and (−1 1 1) reflections of the monoclinic phase and the (1 0 1) peak of the tetragonal phase according to the formula of Toraya et al. [16] : (2) V m = 1.311 X m 1 + 0.311 X m (3) X m = I m ( 1   1   1 ) + I m ( − 1   1   1 ) I m ( 1   1   1 ) + I m ( − 1   1   1 ) + I t ( 1   0   1 ) where X m denotes the integrated intensity ratio, I m and I t are the peak intensities of the m -ZrO 2 and t -ZrO 2 , respectively. The obtained volume fractions of m -ZrO 2 ( V m ) were individually normalized to the volume fractions of ZrO 2 ( V Zr O 2 ) present in each composite as follows: (4) V m t = V m × V Zr O 2 100 Thermal shock tests were performed by measuring the retained flexural strength after quenching into air from desired temperatures. The bars for thermal shock test were heated to desired temperatures for 20 min in a drop-bottom furnace and then air quenched from elevated temperature to room temperature. Thermal quenching was conducted at 623–1423 °C, which corresponded to thermal shock temperature differences (Δ T ) of 600–1400 °C. At least five samples were tested for each temperature difference. 3 Results and discussion 3.1 Phase composition and microstructure X-ray diffraction patterns in the 2 θ range from 20° to 34° of polished surfaces of the composites with different LaPO 4 content are shown in Fig. 1 . Three phases, monoclinic zirconia, tetragonal zirconia and monazite LaPO 4 were observed and no new phase could be found in the XRD patterns. This result indicated that LaPO 4 did not react with ZrO 2 at 1550 °C. The content of m -ZrO 2 in the composites increased with increasing LaPO 4 content ( Table 1 ). It indicated that more spontaneous martensitic transformation occurred with the increased content of LaPO 4 in the ZrO 2 –LaPO 4 composites during cooling from the sintering temperature. Fig. 2 is the SEM micrographs of fracture surfaces of monolithic ZrO 2 (ZLa0), ZLa15 and ZLa30. It was observed that ZLa30 had a homogeneous grain size (about 1 μm) distribution. But some abnormal grains over 2 μm could be easily found in the SEM images of ZLa0, ZLa15 ceramics. This indicated that LaPO 4 inhibited the abnormal grain growth of ZrO 2 during sintering process. Monolithic ZrO 2 ( Fig. 2 (a)) shows both intergranular and transgranular fractures, but ZrO 2 –LaPO 4 composites showed a higher tendency of intergranular fracture, which increased with increasing LaPO 4 content. 3.2 Mechanical properties The relative density and mechanical properties of ZrO 2 –LaPO 4 composites with different LaPO 4 content are shown in Table 2 . The relative density of all the sintered composites was above 98%, which was closed to the theoretical density and was consistent with the dense microstructure in Fig. 2 . The hardness, flexural strength and Vickers toughness decreased with increasing LaPO 4 content. The decrease of Vickers hardness was directly due to the addition of soft LaPO 4 (Young's modulus of LaPO 4 is ∼100 Gpa). Because of the weak-bonding interfaces between LaPO 4 and ZrO 2 , when samples were fractured, less energy was required with the increased content of LaPO 4 , thus resulting in the decrease of flexural strength. When the composite was fractured, part of t -ZrO 2 would transform to m -ZrO 2 , which is known as the stress-induced phase transformation [17] . If more t -ZrO 2 transformed to m -ZrO 2 during the fabrication, the transformation toughening decreased during fracture. It was shown in Table 1 that the content of m -ZrO 2 increased with increasing LaPO 4 content. In addition, the Young's modulus and fracture energy decreased with increasing LaPO 4 content. Consequently, the toughness of the composites decreased with increasing LaPO 4 content. 3.3 Thermal shock resistance In the Hasselman's theory, the residual strength of material after quenching is an important index to estimate the thermal shock resistance. In the current study, specimens of the ZrO 2 –LaPO 4 composites were subjected to a range of temperature differentials by air quenching. The retained flexural strength was then measured in the same way as in Section 2 . The residual strength of ZrO 2 –LaPO 4 composites as a function of thermal shock temperature is shown in Fig. 3 . It was shown that the critical thermal shock temperature (Δ T c ) of ZLa0 and ZLa10 were 1000 °C, indicating that the thermal shock resistance of ZrO 2 was not improved remarkably by adding 10 vol.% LaPO 4 . The Δ T c of ZLa15 was 1200 °C, which was almost the same to that of ZLa20. In the experiment, the highest Δ T c (about 1400 °C) was obtained by ZLa30 composites. The conditions for crack initiation and propagation in ceramics had been extensively analyzed by Hasselman [2] . The condition for stable and unstable crack growth were predicted based on the idea that the driving force for crack propagation was provided by the stored elastic strain energy. A number of thermal shock parameters ( R parameters) were defined to relate thermo-physical and thermo-mechanical properties of the materials to their thermal shock resistance. The effect of microstructure on thermal shock behavior of ZrO 2 –LaPO 4 composite could be demonstrated by using the parameters: (5) R ′ = k σ ( 1 − ν ) E α (6) R IV = K Ic 2 σ 2 ( 1 − ν ) where k is thermal conductivity, σ is the strength, E is the Young's modulus, α is the thermal expansion coefficient, and ν is the Poisson ratio. The R ′ parameter provided a measure of the resistance to crack initiation, while the resistance to crack propagation could be gauged from the R IV parameter. Higher value of R ′ and R IV predicated a higher thermal shock resistance. Because the thermal conductivity and the thermal expansion coefficient of ZrO 2 was very close to those of LaPO 4 [18] , and the Poisson ratio was almost a fixed value for ZrO 2 –LaPO 4 composites, the value size of R ′ and R IV could be determined by σ / E and K Ic / σ , respectively. The calculated value of σ / E and K Ic / σ for ZrO 2 –LaPO 4 composites were also listed in Table 2 . The calculated σ / E value decreased with increasing LaPO 4 content, implying that a decreasing critical temperature differential would be expected. This was opposite to the experimental result in Fig. 3 . It was possible that micro-cracks in the composites did indeed initiated for a relatively low Δ T , but that the high damage resistance of the composites resulted in minimal crack propagation and consequent strength degradation. Such a claim was also supported by the calculated value of K Ic / σ , which was increased with increasing LaPO 4 content. The results of the SEM and energy spectrum indicated that the weak interfaces between ZrO 2 and LaPO 4 particles and the layered structure of LaPO 4 played the very important role in resisting the propagation of thermal shock induced micro-cracks. The evidence was shown in Fig. 4 . It could be observed that the thermal shock induced crack was discontinuous and propagated along the interfaces between LaPO 4 and ZrO 2 . The crack deflection and divergence would lead to a partial relief of the thermoelastic strain energy and hence, contributed to resistance to crack propagation. Moreover, the increasing phase transformation of zirconia in ZrO 2 –LaPO 4 composites would contribute to the resistance to crack propagation ( Table 1 ). Consequently, stable crack propagation was possible during air quenching, thus minimizing the strength degradation as demonstrated in the strength versus air quenching temperature response of the ZrO 2 –LaPO 4 composite ( Fig. 3 ). 4 Conclusions 4YSZ–LaPO 4 composites with different LaPO 4 content ranging from 0 to 30 vol.% were prepared. Microstructure, mechanical properties and several parameters relevant to the thermal shock resistance including critical temperature differential, R ′ and R IV were evaluated and discussed. With the increased content of LaPO 4 , the Vickers hardness, flexural strength and toughness of the composites decreased gradually, but the thermal shock resistance was improved obviously. The critical temperature differential of thermal shock resistance for the ZLa30 composite was found to be higher than for monolithic 4YSZ (ZLa0) experimentally as much as 400 °C. Higher ratio value of K Ic / σ and the crack deflection at weak bonding interface between ZrO 2 and LaPO 4 were the main factors to improve the thermal shock resistance of the 4YSZ–LaPO 4 composites. Acknowledgements This research was supported by the National High Technology Research and Development Program of China (863 program) under grant No. 2006AA03Z540, and the National Natural Science Foundation of China under grant No. 50772073. References [1] G.W. Liu W. Li G.J. Qiao H.J. Wang J.F. Yang T.J. Lu J. Alloy Compd. 470 2009 163 167 [2] I. Ganesh J.M.F. Ferreira Ceram. Int. 35 2009 259 264 [3] Z.G. Liu J.H. Ouyang Y. Zhou J. Li J. Alloy Compd. 468 2009 350 355 [4] D.P.H. Hasselman J. Am. Ceram. Soc. 46 11 1963 535 540 [5] D.P.H. Hasselman J. Am. Ceram. Soc. 52 1969 600 604 [6] L.D. Schwartz C.M. Lukaniuk T.H. Etsell Adv. Eng. Mater. 1 1999 111 113 [7] J. Li Y.S. Yin X.Y. Tan J.D. Zhang J. Am. Ceram. Soc. 88 1 2005 235 238 [8] B. Zhu S. Ma J. Bu Z. Wang J. Sun J. Chinese Ceram. Soc. 36 2 2008 228 232 [9] X. Zhang R. Zhang G. Chen W. Han Mater. Sci. Eng. A 497 2008 195 199 [10] R.L. Wang Z.F. Wang J.L. Bu L.F. Zhang Key. Eng. Mater. 368–372 Pt 1 2008 778 780 [11] X. Zhang W. Li C. Hong W. Han J. Han Scripta Mater. 59 2008 1214 1217 [12] P.E.D. Morgan D.B. Marshall J. Am. Ceram. Soc. 78 6 1995 1553 1563 [13] J.B. Davis D.B. Marshall R.M. Housley P.E.D. Morgan J. Am. Ceram. Soc. 81 8 1998 2169 2175 [14] K. Niihara R. Morena D.P.H. Hasselman J. Mater. Sci. Lett. 1 1 1982 13 16 [15] Z.H. Zhou P.D. Ding S.H. Tan J.S. Lan Mater. Sci. Eng. A 405 2005 272 276 [16] H. Toraya M. Yoshimura S. Somiya J. Am. Ceram. Soc. 67 1984 119 121 [17] R.H.J. Hannink P.M. Kelly B.C. Muddle J. Am. Ceram. Soc. 83 2000 461 487 [18] M. Wu K. Daimon T. Matsubara Y. Hikichi Mater. Res. Bull. 37 2002 1107 1115",
        "keywords": [
            "Ceramics",
            "Composites",
            "Mechanical properties",
            "Microstructure",
            "Scanning electron microscopy"
        ],
        "authors": [
            {
                "name": "Zhongqiu Li",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Shun Li",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "UXq6pob4": {
        "id": "UXq6pob4",
        "title": "Gradient MoSi 2 -borosilicate glass high emissivity coating with enhanced contact and impact damage resistance",
        "abstract": "Abstract   High emissivity coatings on fibrous insulation tiles played an important role in thermal protection systems and thereby intrigued many researchers; however, there was little emphasis on the mechanical properties of the coatings. In this study, a gradient MoSi 2 -borosilicate glass coating with a dense surface layer and a porous interlayer was designed for mullite fibrous ceramics. Mechanical properties and structure parameters of the coating layers and the substrate were studied. The gradient coating was compared with a monolayer dense coating of the same composition and same surface density in contact damage resistance, impact resistance and emissivity. Compared with monolayer dense coating coated substrates, the gradient coating coated ones exhibited two times higher load bearing capacity in Hertzian indentation test at the same displacement of 1 mm; they appeared to be stiffer and harder at constant load of 20 N, and showed better impact resistance at impact energy range of 0.25–0.75 J in the falling weight test; besides, fatal radial cracks were not observed in gradient coatings after the tests. In addition, the gradient coating had higher emissivity (0.838) than the monolayer dense coating (0.816) because of the significant absorptivity increase and reflectivity decrease by small gradual slopes in the rough surface.",
        "keywords": "",
        "authors": [
            {
                "name": "Liang Xian",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Xin Tao",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Xin Tao",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Wei Dong",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, PR China"
            },
            {
                "name": "Xiaojing Xu",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, PR China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2018
    },
    "HVNnIv9E": {
        "id": "HVNnIv9E",
        "title": "Synthesis and properties of porous alumina ceramics with inter-locked plate-like structure through the tert-butyl alcohol-based gel-casting method",
        "abstract": "Abstract   Porous alumina ceramics with inter-locked plate-like structure were successfully fabricated by the  tert -butyl alcohol-based gel-casting method. The effects of Al/Si mole ratio on the structure and properties of the obtained products were investigated. The formation process of the inter-locked structure was analyzed. The products fabricated with the one-step method, in which the growth of plate-like alumina and the formation of the inter-locked structure were combined together, exhibited a high porosity of 76.21%, a compressive strength of 0.525 MPa and a low thermal conductivity of 0.495 W/mK, while the products fabricated by the two-step method after sintered at 1500 °C using the grinded powders after 700 °C heat-treatment as the starting materials possessed a relatively high compressive strength of 4.80 MPa. The obtained porous alumina ceramics were promising flexible insulant materials for the application in high-temperature field.",
        "keywords": "",
        "authors": [
            {
                "name": "Xue Dong",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Mingchao Wang",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Yongxin Zhang",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Sue Ren",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Guofa Sui",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2017
    },
    "hjrbJhxJ": {
        "id": "hjrbJhxJ",
        "title": "Preparation of porous Y2SiO5 ceramics with relatively high compressive strength and ultra-low thermal conductivity by a TBA-based gel-casting method",
        "abstract": "Porous Y2SiO5 ceramics with relative high compressive strength (as high as 24.45 MPa) and ultra-low thermal conductivity (∼0.08 W/m K) were successfully fabricated by a tert-butyl alcohol based gel-casting method. The formation mechanism of the 3D interconnected pores and the properties of the green body are discussed. The porosity, pore size, compressive strength and thermal conductivity could be controlled by varying the initial solid loading and the sintering temperature. When regulating the initial solid loading (from 20 to 50 wt%) and sintering temperature (from 1200 to 1500 °C), the porosity can be controlled between 47.74% and 73.93%, and the compressive strength and the thermal conductivity of porous Y 2SiO5 ceramics varied from 3.34 to 24.45 MPa and from 0.08 to 0.55 W/m K, respectively. It should be noted that the porous Y 2SiO5 ceramics with 30 wt% solid loading and sintering at 1400 °C had an open porosity of 61.80%, a pore size of 2.24 μm, a low room-temperature thermal conductivity of 0.17 W/m K and a relatively high compressive strength of 13.91 MPa, which make this porous Y2SiO 5 ceramics suitable for applications in high-temperature thermal insulators. © 2012 Elsevier Ltd and Techna Group S.r.l.",
        "keywords": [
            "Compressive strength",
            "TBA-based gel-casting",
            "Thermal conductivity",
            "Y2SiO5"
        ],
        "authors": [
            {
                "name": "Zhenguang Hou",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Hai Xu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Anran Guo",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Min Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "2rJJpOv5": {
        "id": "2rJJpOv5",
        "title": "Influence of the coating preparation method and of nanosilica addition on the bonding character of Si 3 N 4 layer on a silica crucible",
        "abstract": "",
        "keywords": [
            "permeation"
        ],
        "authors": [
            {
                "name": "xiaoxiao gong",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "xiaoyan zhang",
                "org": ""
            },
            {
                "name": "xiaoxia hu",
                "org": ""
            },
            {
                "name": "dingyin zhang",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2014
    },
    "GtwFbR3y": {
        "id": "GtwFbR3y",
        "title": "Effect of fly ash cenospheres on the microstructure and properties of silica-based composites",
        "abstract": "Effects of fly ash cenospheres on the microstructure and properties of silica-based composites were studied in this paper. It was found that the density of the samples decreased as the content of fly ash cenospheres increased, while the strength increased inversely when the content was lower than 50 wt%. An interlaced microstructure of lath-like and needle-like mullite crystals was discovered in the composites, which was a beneficial factor for strengthening the silica matrix. Furthermore, the results indicated that fly ash cenospheres can promote the densification of silica as a sintering aid and restrain the crystallization of cristobalite as an inhibitor. After sintered at 1200°C for 2 h, the density and flexural strength of silica-based composites with 50 wt% fly ash cenospheres were 0.92 g/cm 3 and 14.5 MPa separately, and the strength was as high as that of the silica ceramics without fly ash cenospheres. © 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.",
        "keywords": [
            "b. composite",
            "b. porosity",
            "c. mechanical properties",
            "microstructure",
            "silica"
        ],
        "authors": [
            {
                "name": "Caifen Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Anran Guo",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2012
    },
    "CgySxV9u": {
        "id": "CgySxV9u",
        "title": "Study of the microwave assisted alumina ceramic Mo-Mn metallization process and mechanism",
        "abstract": "Based on 95Al2O3 ceramics as a matrix and Mo-Mn system as metal compositions, the metallization was carried put on ceramic surface by microwave technique. Effects of microwave power, holding time, protection measures and loading scheme of microwave on the qualities of metallization were investigated. Composition and microstructure of the metalized surface were analyzed by XRD and SEM respectively. It was showed that ideal metalized quality could be achieved by 3 kW/20 min microwave treating with gradual loading of power and protecting measure of buried C powder.",
        "keywords": [
            "Al2O3",
            "Metallization",
            "Microwave"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Wei Jing",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Caifen Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Yadian Yu Shengguang/Piezoelectrics and Acoustooptics",
        "year": 2008
    },
    "7WGdGdJH": {
        "id": "7WGdGdJH",
        "title": "Microstructure characterization of in situ synthesized porous Si 2N2O ceramics using spodumene additive",
        "abstract": "Porous Si2N2O ceramics was synthesized by the tert-butyl alcohol-based gel-casting method at a relatively low temperature using Si3N4 and SiO2 powders as the starting materials and spodumene (LiAl(SiO3)2) as the sintering additive. Porous Si2N2O ceramics with relative high compressive strength (10.80 MPa) and high porosity (65.5%) were successfully fabricated. The microstructure of porous Si2N2O after sintering at different sintering regimes was studied. The fibers observed in the pores can increase the compressive strength and the specific surface area of the sample. © 2012 Elsevier Ltd and Techna Group S.r.l.",
        "keywords": [
            "A. Sintering",
            "Ceramics",
            "Fibers",
            "TBA-based gel-casting"
        ],
        "authors": [
            {
                "name": "Xue Dong",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Anran Guo",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Mengxia Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "shsP3mkl": {
        "id": "shsP3mkl",
        "title": "Fabrication of TiO_2 Thin Film by Electrostatic Self-Assembly Method on Optical Fiber",
        "abstract": "Anionic surfactant sodium lauryl sulfate(SDS), cationic surfactant palmityl trimethyl ammonium chloride(CTAC) and TiO_2 were used to prepare multilayer films on quartz optic fibers by the electrostatic self-assembly (ESA) method. The whole self-assemble process, the function of surfactant and the effect of TiO_2 slurry′s concentration to the self-assemble were discussed. The isoelectric point of TiO_2 slurry measured by experiment is 6.8. The results show that whatever the concentration of the TiO_2 dispersion, a flat and compact adsorbed monolayer on the optic fiber can be built in a stable dispersion at lower pH. There is a adsorbed equilibrium on the substrate (fiber)/solution interface when enough time of incubation is given. A rough and loosen adsorbed layer is formed on the fiber surface by immersed the substrate in a high pH dispersion (pH>10) because the presence of hydroxyl on particle surface. Film thickness can be controlled by controlling the number of layers in the film.",
        "keywords": [
            "thin film",
            "surfactant",
            "titania",
            "electrostatic self-assembly"
        ],
        "authors": [
            {
                "name": "Han Jing",
                "org": "School of Materials Science and Engineering, Key Laboratory of Advanced Ceramics and Machining Technology,Tianjin University, Tianjin , China"
            },
            {
                "name": "Du Haiyan",
                "org": "School of Materials Science and Engineering, Key Laboratory of Advanced Ceramics and Machining Technology,Tianjin University, Tianjin , China"
            },
            {
                "name": "Wang Yuling",
                "org": "School of Materials Science and Engineering, Key Laboratory of Advanced Ceramics and Machining Technology,Tianjin University, Tianjin , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2005
    },
    "OVQADR7g": {
        "id": "OVQADR7g",
        "title": "Highly efficient Pt/TiO 2 photocatalyst prepared by plasma-enhanced impregnation method",
        "abstract": "Highly efficient Pt/TiO 2 photocatalyst has been prepared using plasma-enhanced impregnation method. Impregnated 0.5 wt%Pt/TiO 2 was treated by plasma followed with thermal calcinations and hydrogen reduction. The catalyst characterizations show that Pt is highly dispersed with a size of 3-5 nm. UV-Vis reflection spectrum suggests it a high photosensitivity in near UV region. Such plasma prepared catalyst exhibits a much higher activity and better metal stability for hydrogen generation from methanol/water mixture, compared to the catalyst prepared conventionally. This highly efficient photocatalyst should have extensive applications in photocatalytic processes. © 2004 Elsevier B.V. All rights reserved.",
        "keywords": [
            "spectrum"
        ],
        "authors": [
            {
                "name": "Jijun Zou",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Changjun Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Kailu Yu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Dangguo Cheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yueping Zhang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Fei He",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Lan Cui",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Chemical Physics Letters",
        "year": 2004
    },
    "IY3JZCNv": {
        "id": "IY3JZCNv",
        "title": "Molten salt synthesis of mullite whiskers from various alumina precursors",
        "abstract": "Different reaction processes were observed in the preparation of mullite whiskers by molten salt synthesis (MSS) when Al 2 (SO 4 ) 3 and Al(OH) 3 used as alumina precursors. It was found that amorphous Al 2 O 3 from Al 2 (SO 4 ) 3 reacted with silica to form mullite in Na 2 SO 4 flux at 900–1100 °C, whereas γ-Al 2 O 3 from Al(OH) 3 did not participate the synthesis reaction of mullite. The formation of tiny-sized amorphous Al 2 O 3 resulted from both free Al-cations in liquid and amorphous silica by means of Al 2 (SO 4 ) 3 . In addition, mullite with 67 mol% Al 2 O 3 formed in 1/1, 2/1 and 3/1 mixtures while mullite with 72 mol% Al 2 O 3 formed in 4/1 mixture, when powder mixtures [Al 2 (SO 4 ) 3 as alumina precursor] with Al/Si atomic ratios of 1/1, 2/1, 3/1 and 4/1 were used. The formation of Al-rich mullite was ascribed to the low synthesizing temperature by MSS. Keywords Ceramics Crystal growth Anisotropy Scanning electron microscopy X-ray diffraction 1 Introduction Mullite is a kind of superior engineering materials due to their excellent mechanical property and especially its strength retained up to 1300 °C [1,2] . So it is an important component in composite [3] , porous [4] and membranous [5,6] ceramics. However, various processing routes have been reported for the preparation of mullite powders such as sol–gel precursors [7,8] , thermal decomposition of minerals [9] , rare earth oxide doping [10,11] and internal crystallization method [12] , developing new approaches to prepare mullite whiskers in controlled morphology still remains a challenge. As a new ceramic powder synthesis method, molten salt synthesis (MSS) has been employed to synthesize ceramic powders because it decreases reaction temperature and gives powders of homogeneous morphology [13,14] . Al 2 (SO 4 ) 3 was used as alumina precursor to form mullite via 3Al 2 O 3 + 2SiO 2 = Al 6 Si 2 O 13 in molten alkali-metal sulfates [15] . Ouatib concluded that γ-Al 2 O 3 ( F d 3 ¯ m ) formed from the decomposition of Al 2 (SO 4 ) 3 and then reacted with silica to form mullite [16] , but there was no specific demonstration. At the same time, the formation of amorphous Al 2 O 3 by the decomposition of Al 2 (SO 4 ) 3 in molten sodium sulfate was observed [17] . Thus, it was necessary to investigate the reaction process to form mullite via MSS. In this work, together with Al 2 (SO 4 ) 3 , Al(OH) 3 were used as another alumina precursor to study the reaction process owing to its low decomposition temperature [18] . Besides the sort of starting materials, Al/Si ratio of starting materials is another factor that has a significant effect on the composition and morphology of mullite [19] . In mullite whiskers synthesized by solid-state reaction [20,21] , Si-rich composition was suggested to facilitate the growth of anisotropic mullite that contained low Al 2 O 3 content (i.e. <60 mol% Al 2 O 3 ). In comparison with traditional solid-state reaction, MSS has several advantages, such as low processing temperature, better control of composition, high homogeneity and purity as well as a liquid environment. Thus, the relationship between the composition and morphology of mullite and the Al/Si ratio of starting materials in MSS may be different from that for solid-state reaction synthesis. To the best of our knowledge, there has been scarce report on the successful synthesis of mullite whiskers via MSS. In present study, reaction processes in MSS with different alumina precursors were reported. The composition and morphology of mullite prepared by firing powder mixture with various Al/Si ratios were investigated. 2 Experimental procedures As raw materials, aluminum sulfate [Al 2 (SO 4 ) 3 ] (>99% purity), aluminum hydroxide [Al(OH) 3 ] (>99% purity), amorphous silica (>99% purity, 25 μm in size) and sodium sulfate (Na 2 SO 4 , mp = 884 °C [22] ) (>99% purity) (Jiangtian Chemical Co., Tianjin, China) were used. Powder mixtures were ball-milled for 4 h and then fired in alumina crucibles at a heating rate of 300 °C/h. The compositions and firing conditions of all power mixtures are shown in Table 1 . The prepared samples were washed with 95 °C water to remove the sulfate. Finally, white powders were obtained after drying at 80 °C for 24 h. Crystalline phase and morphology of the powders were examined by X-ray diffraction (XRD, D/MAX 2500 Rigaku) and scanning electronic microscope (SEM, XL-30 Philips), respectively. Element contents were detected by using EDS attached to the SEM. In order to explain different reaction processes with various alumina precursors, differential thermal analysis (DTA) and thermo gravimetric analysis (TG) were performed up to 1200 °C at a heating rate of 10 °C/min in air. 3 Results and discussion 3.1 Effect of alumina source on mullite formation Fig. 1 shows XRD patterns of the products obtained by firing powder mixtures with various alumina precursors (S 12 and S 22 ) at 900–1100 °C for 3 h. It was found that mullite was the main crystalline phase in S 12 ( Fig. 1 a). With temperature increasing to 1000 °C, the line width decreased while intensity of the diffraction line increased, demonstrating an improvement in crystallinity and an increase in the amount of mullite. Residual amorphous silica was gradually transformed to cristobalite above 1000 °C. α-Al 2 O 3 in S 12 appeared at 1000 °C, while there was no crystal Al 2 O 3 at 900 °C. On the other hand, Lazurite [Na 8.16 (Al 6 Si 6 O 24 )(SO 4 ) 1.14 S 0.86 ] was detected in S 22 ( Fig. 1 b). Fig. 2 shows morphology of the products obtained by firing S 12 and S 22 at 1000 °C for 3 h. Mullite whiskers were observed in S 12 ( Fig. 2 a) while irregularly shaped Lazurite was observed in S 22 ( Fig. 2 b). Fig. 3 shows XRD patterns of the products obtained by firing S 12 and S 22 at 900 °C without heat preservation. The consistent diffraction peak at 14–25° in both XRD patterns resulted from amorphous SiO 2 . γ-Al 2 O 3 formed by the decomposition of Al(OH) 3 was detected in S 22 while no peak of crystal Al 2 O 3 was detected in S 12 . It suggested that the Al 2 O 3 formed in S 12 might be in an amorphous state. The conclusion was further validated by EDS analysis that it contained 46.75% Al and 53.25% Si (atomic ratio). Fig. 4 a shows DTA curves of S 12 and S 22 . When S 12 was fired, a liquid phase of Al 2 (SO 4 ) 3 –Na 2 SO 4 due to the low-melting point, formed at approximate 640 °C [23] , resulting in endothermic peak (a) in the DTA curve. According to previous reports [24,25] , exothermic peak (b) was caused by the formation of mullite at approximate 900 °C. As shown in Fig. 4 b, the remarkable weight loss indicated in TG curve of S 12 , was due to the decomposition of Al 2 (SO 4 ) 3 above 700 °C [11] . In DTA curve of S 22 , endothermic peak (c) was thought to be caused by the decomposition of Al(OH) 3 at about 300 °C [14] . Another endothermic peak (d) after 880 °C (close to the melting point of Na 2 SO 4 ) was due to the formation of Na 2 SO 4 liquid. At higher temperature, the formation of Lazurite caused exothermic peak (e). The DTA and TG results indicated that the reaction processes in S 12 and S 22 were different. The reaction order (1) in S 12 is as follows: the formation of a liquid, the decomposition of alumina precursor and the formation of mullite. On the other hand, the reaction (2) in S 22 is in the order of the decomposition of alumina precursor, the formation of a liquid and the formation of product. As is well known, free cations and anions formed when electrolyte is fired above melting point. According to this principle, free Al-cations firstly formed in liquid before decomposition of Al 2 (SO 4 ) 3 followed reaction process (1), and then they transformed to tiny-sized amorphous Al 2 O 3 above 700 °C. It was found that amorphous silica retarded the polymorph transformation of Al 2 O 3 by preventing particles from coming into contact and suppressing nucleation on the Al 2 O 3 surface in former research [26] . In this case, the crystallization and growth of amorphous Al 2 O 3 were prevented by amorphous silica. The co-existence of free Al-cations in liquid and amorphous silica resulted in the formation of tiny-sized amorphous Al 2 O 3 with high reactivity. It explained the phenomenon that there was no characteristic peak of crystal Al 2 O 3 detected in XRD pattern of S 12 after the decomposition of alumina precursor, as shown in Fig. 3 . Amorphous silica reacted with amorphous Al 2 O 3 to form mullite, which precipitated from liquid as final product. On the other hand, when firing S 22 , γ-Al 2 O 3 firstly formed by the decomposition of Al(OH) 3 . Compared with amorphous Al 2 O 3 with high reactivity, γ-Al 2 O 3 cannot form mullite at low temperature. Instead, it reacted with amorphous silica and molten Na 2 SO 4 to form Lazurite that is scarcely reported before. The observed result is not in agreement with Ouatib's conclusion [16] . It can be concluded that amorphous Al 2 O 3 is beneficial for the formation of mullite in MSS. 3.2 Characterization of whiskers: effect of Al/Si on composition and morphology of mullite The dependence of cell dimensions on Al/Si ratios has been well investigated a and c increase, and b decreases with increasing Al/Si ratios, resulting in the transformation of mullite from the orthorhombic ( a = 0.76 nm, b = 0.77 nm, and c = 0.29 nm) to the tetragonal ( a = b ) [27] . Thus, Al/Si ratio in mullite can be reflected by the 120 and 210 peaks, which are split in orthorhombic and overlapped in tetragonal. Fig. 5 shows angular separation of the 120 and 210 peaks of mullite prepared by firing powder mixtures with 1/1, 2/1, 3/1 and 4/1 (Al/Si, atomic ratios), which were named as S 11 , S 12 , S 13 , and S 14 , respectively ( Table 1 ). The 120 and 210 peaks moved closer together in S 14 , while there was no change in the position of the 120 and 210 peaks in S 11 , S 12 and S 13 . It was concluded that Al 2 O 3 contents in mullite derived from Al-deficient S 11 and S 12 and stoichiometric S 13 compositions are very close. On the other hand, the changing of angular separation of the 120 and 210 peaks indicated that mullite prepared with S 14 contained higher Al 2 O 3 content. Fig. 6 shows SEM of the powder mixtures with various Al/Si fired at 1000 °C for 3 h, etched with 20 wt% HF for 20 min at room temperature. The EDS spectrum taken from the whiskers showed the compositions of mullite prepared with various Al/Si ratios. Anisotropic mullite was observed in all four samples, which contained approximate 67 mol% Al 2 O 3 for S 11 , S 12 and S 13 and approximate 72 mol% Al 2 O 3 for S 14 . In a conclusion, mullite whiskers prepared by firing powder mixtures with Al-rich compositions contained higher Al 2 O 3 content than those with Al-deficient and stoichiometric compositions. The EDS analysis was in good agreement with the XRD result. In previous research, anisotropic grains were observed in Al-deficient mullite prepared by solid-state method [20,21] . However, anisotropic grains were observed in Al-rich mullite by MSS. The difference was ascribed to the liquid environment provided by molten flux which facilitates the growth of anisotropic mullite. Another interesting phenomenon was that Al-deficient and stoichiometric mullite did not form, regardless of the Al/Si = 1/1, 2/1 or 3/1, molar ratio of the powder mixtures. Okada et al. [28] reported that the Al-rich mullite synthesized at lower temperatures corresponded to primary mullite (tetragonal-like), and those synthesized at higher temperatures corresponded to ordinary mullite (orthorhombic mullite). According to this principle, the formation of Al-rich mullite was ascribed to the low synthesizing temperature by MSS. In addition, the same phenomenon was observed when mullite whiskers were synthesized below 1100 °C by a vapor–solid reaction [29] . 4 Conclusions Different reaction processes were studied when firing powder mixtures with Al 2 (SO 4 ) 3 and Al(OH) 3 as alumina precursors. Amorphous Al 2 O 3 is beneficial for the formation of mullite by MSS. Anisotropic grains were formed in Al-rich mullite by MSS. The mullite whiskers prepared with 1/1, 2/1 and 3/1 powder mixtures contained about 67 mol% Al 2 O 3 , while those prepared with 4/1 powder mixture contained about 72 mol% Al 2 O 3 . The formation of Al-rich mullite was ascribed to the low synthesizing temperature by MSS. Acknowledgements This work was supported by the National High-Technology Research and Development Program of China (863 program) under grant no. 2006AA03Z540 , the National Natural Science Foundation of China under grant no. 50772073 , and the High-technology Research and Development Center in Shuozhou City. References [1] F. Gridi-Bennadji D. Chateigner G.D. Vita P. Blanchart J. Eur. Ceram. Soc. 29 2009 2177 2184 [2] M.G.M.U. Ismail Z. Nakai S. Somiya J. Am. Ceram. Soc. 70 1987 C7 C8 [3] Z.G. Zhang M.C. Wang M. Li Z.J. Sun J. Am. Ceram. Soc. 92 2009 1129 1132 [4] A. Esharghawi C.C. Penot F. Nardou J. Eur. Ceram. Soc. 29 2009 31 38 [5] Y.C. Dong X.Y. Feng X.F. Feng Y.W. Ding X.Q. Liu G.Y. Meng J. Alloys Compd. 460 2008 599 606 [6] Y.C. Dong B. Lin K. Xie S.L. Wang J. Alloys Compd. 477 2009 350 356 [7] Y.B. Zhang Y.P. Ding J.Q. Gao H.F. Yang J. Eur. Ceram. Soc. 29 2009 1101 1107 [8] J. Leivo M. Linden M. Ritola M. Vippola E. Levanen Mater. Chem. Phys. 115 2009 56 64 [9] J.F. Li H. Lin J.B. Li J. Wu J. Eur. Ceram. Soc. 29 2009 2929 2936 [10] F.J. Serrano E.R. de Sola M.A. Kojdecki J.M. Amigo J. Alarcon J. Am. Ceram. Soc. 91 2008 3522 3529 [11] B. Bagchi S. Das A. Bhattacharya R. Basu P. Nandy J. Am. Ceram. Soc. 92 2009 748 751 [12] S.T. Mileiko A.V. Serebryakov V.M. Kiiko A.A. Kolchin J. 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Kameshima A. Yasumori K. Okada J. Eur. Ceram. Soc. 21 2001 2487 2493 [25] H. Schneider L. Merwin A. Sebald J. Mater. Sci. 27 1992 805 812 [26] Y. Saito T. Takei S. Hayashi A. Yasumori K. Okada J. Am. Ceram. Soc. 81 1998 2197 2200 [27] J. Ossaka Nature 191 1961 1000 1001 [28] K. Okada Y. Hoshi N. Otsuka J. Mater. Sci. Lett. 5 1986 1315 1318 [29] K. Okada N. Otsuka J. Am. Ceram. Soc. 74 1991 2414 2418",
        "keywords": [
            "anisotropy",
            "ceramics",
            "crystal growth",
            "scanning electron microscopy",
            "x-ray diffraction",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "Pengyu Zhang",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, No. 92, Weijin Street, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, No. 92, Weijin Street, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Zhongqiu Li",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, No. 92, Weijin Street, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Shun Li",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, No. 92, Weijin Street, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Sha Li",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, No. 92, Weijin Street, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Rui Xu",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, No. 92, Weijin Street, Tianjin 300072, People's Republic of China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2010
    },
    "IwHjOkza": {
        "id": "IwHjOkza",
        "title": "Three-dimensional mullite fiber network with controllable hierarchical structure for effective soot combustion",
        "abstract": "Abstract   It has been proved that the secondary structure assembled on each fiber in the porous fiber network can catch the ultrafine particles easily in filtration process. In this work, three different networks without (naked fiber) or with different secondary structure (mullite whisker/mullite fiber or corundum plate/mullite fiber) were prepared to investigate the influence of secondary structure on the high temperature mechanical property and the soot oxidation. The mullite whisker/mullite fiber (MW/MF) network exhibited the best high temperature compress resistence and lowest soot oxidation temperature. The soot oxidation start temperatures were 434 °C and 443 °C in the mullite whisker/mullite fiber (MW/MF) and corundum plate/mullite fiber (CP/MF) webs respectively, which was lower than that in the Naked mullite fiber (MF) web (473 °C). Thus, fiber webs assembled with secondary structures have been shown to be promising filter with effective soot oxidation activity.",
        "keywords": "",
        "authors": [
            {
                "name": "Lina Yang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Qingzhao Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jianchen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Lingyu Li",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Dieni Xie",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2017
    },
    "U9ouW7VA": {
        "id": "U9ouW7VA",
        "title": "Preparation and structure control of a scalelike MoSi2-borosilicate glass coating with improved contact damage and thermal shock resistance",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jinyu Wu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, PR China"
            },
            {
                "name": "Xiaojing Xu",
                "org": "Systems Engineering Business Department, China Academy of Launch Vehicle Technology, Beijing, 100076, China"
            },
            {
                "name": "Yanli Xiong",
                "org": "Systems Engineering Business Department, China Academy of Launch Vehicle Technology, Beijing, 100076, China"
            },
            {
                "name": "Xingyu Guan",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, PR China"
            },
            {
                "name": "Mengyu Jiao",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, PR China"
            },
            {
                "name": "Xinghe Yao",
                "org": "Systems Engineering Business Department, China Academy of Launch Vehicle Technology, Beijing, 100076, China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, PR China"
            },
            {
                "name": "Shunyi Xu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, PR China"
            },
            {
                "name": "Xin Tao",
                "org": "College of Science, Civil Aviation University of China, Tianjin, 300300, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, PR China"
            }
        ],
        "venue": "",
        "year": 2019
    },
    "LyaF6Gg9": {
        "id": "LyaF6Gg9",
        "title": "Structure formation process, heat-insulation property and cyclic compression–resilience performance of mullite fibres/whiskers frameworks",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shan liu",
                "org": "tianjin university"
            },
            {
                "name": "jiachen liu",
                "org": "tianjin university"
            },
            {
                "name": "haiyan du",
                "org": "tianjin university"
            },
            {
                "name": "feng hou",
                "org": "tianjin university"
            },
            {
                "name": "sue ren",
                "org": "tianjin university"
            },
            {
                "name": "haitao geng",
                "org": "tianjin university"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "oAQ5FE9q": {
        "id": "oAQ5FE9q",
        "title": "Preparation of porous Y 2 SiO 5 ceramics with relatively high compressive strength and ultra-low thermal conductivity by a TBA-based gel-casting method",
        "abstract": "",
        "keywords": [
            "compressive strength",
            "thermal conductivity"
        ],
        "authors": [
            {
                "name": "zhenguang hou",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "hai xu",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "min wang",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "Uuu63oGG": {
        "id": "Uuu63oGG",
        "title": "Fabrication of mullite fiber porous ceramics with even structures by filtration freeze-drying",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Dingyin Zhang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Lingyu Li",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Xiaoping Chen",
                "org": "Analysis and Testing Center of Tianjin University"
            },
            {
                "name": "Lina Yang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Dieni Xie",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Wenjie Wang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            }
        ],
        "venue": "Journal of The Ceramic Society of Japan",
        "year": 2019
    },
    "8KCrmq2t": {
        "id": "8KCrmq2t",
        "title": "Microstructure and properties of the inter-locked corundum/mullite structure",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shan liu",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "yingna zhao",
                "org": ""
            },
            {
                "name": "feng hou",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2014
    },
    "Z2jXXorX": {
        "id": "Z2jXXorX",
        "title": "CO2 reforming of methane over argon plasma reduced Rh/Al 2O3 catalyst: A case study of alternative catalyst reduction via non-hydrogen plasmas",
        "abstract": "An argon glow discharge plasma was used to reduce RhCl3 impregnated Al2O3 powder at room temperature. The obtained sample was characterized by chemisorption, X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) equipped with an energy dispersion X-ray spectrometer (EDX). XRD and EDX analyses confirmed that Rh ions were reduced into metallic Rh during the plasma reduction. TEM analysis revealed that the argon plasma reduction induces a high dispersion of Rh nano-particles. The average particle size of Rh is 1.2 nm, estimated by chemisorption. For the CO2 reforming of methane, the plasma reduced Rh/Al2O 3 shows comparable activity to a conventional hydrogen reduced catalyst. The value of the standard electrode potential can be employed for the assessment of reducibility of metal ions. The catalyst reduction using argon glow discharge plasma at room temperature will provide a promising alternative to hydrogen reduction for catalyst preparation. © The Royal Society of Chemistry.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhou-jun Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yu Zhao",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Lan Cui",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Pei Yao",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Chang-jun Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Green Chemistry",
        "year": 2007
    },
    "gmBAYZ9t": {
        "id": "gmBAYZ9t",
        "title": "Phase-controllable synthesis of CuxS nanocrystals by an ambient pressure tetraethylene glycol solution process",
        "abstract": "An ambient pressure solution chemical process using tetraethylene glycol as solvent, copper(II) chloride and thioacetamide as precursors, polyvinylpyrrolidone as capping agent synthesized CuxS (x = 1 or 1.8) nanocrystals by injecting Cu(II) precursor solution into thioacetamide precursor solution at 200-280 C. Influence of the synthesized temperature and refluxing time on the formed phases and growing morphologies of CuxS nanocrystals was investigated based on XRD, TEM, HRTEM and EDX. Optical properties of the synthesized CuxS nanocrystals were characterized. The results showed that single-phase, snowflake-like shaped covellite CuS nanocrystals were formed at injection temperature of 220 C and below. And single-phase, well-dispersed, polyhedral-shaped digenite Cu1.8S nanoparticles were grown at injection temperature of 260 C and above. The formation mechanism of the CuS and Cu1.8S nanocrystals in this phase-selective solution synthesis was discussed. © 2013 Elsevier B.V.",
        "keywords": [
            "CuxS nanocrystals",
            "Phase-controlling",
            "Solution chemical synthesis",
            "Tetraethylene glycol solvent"
        ],
        "authors": [
            {
                "name": "Xuerong Zheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Hui Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yueqiu Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Xin Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2013
    },
    "oS9ktIqs": {
        "id": "oS9ktIqs",
        "title": "Influence of fibers on the microstructure and compressive response of directional ice-templated alumina ceramics",
        "abstract": "Abstract   Directional ice-templated ceramics have unique lamellar porous channels between ceramic walls which run from bottom to top of the samples. This highly oriented morphology results in the anisotropy in mechanical properties both parallel and perpendicular to freezing direction. In this research, fiber-enhanced ice-templated porous ceramics were fabricated by introducing fibers into alumina slurry for freezing. The trans-lamellar fiber bridges connecting adjacent ceramic walls were formed by adjusting the aspect ratio of fibers and freezing velocity, which greatly enhanced the compressive response in two directions and weakened the anisotropy in mechanical properties of the directional ice-templated ceramics. The results showed that the of fiber bridges increased with the increase of fiber aspect ratio and the longitudinal and transverse mechanical properties increased by 73.5% and 232.6%, respectively.",
        "keywords": "",
        "authors": [
            {
                "name": "Lingyu Li",
                "org": ""
            },
            {
                "name": "Zhiyun Li",
                "org": "China Aerospace Science and Technology Corporation, Beijing 100048, PR China"
            },
            {
                "name": "Xiutao Li",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, PR China"
            },
            {
                "name": "Xiqing Xu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2018
    },
    "FyKRlAO2": {
        "id": "FyKRlAO2",
        "title": "Single-phase and well-dispersed Cu 1.75 S nanocrystals by ambient pressure diethylene glycol solution synthesis",
        "abstract": "",
        "keywords": [
            "crystal growth"
        ],
        "authors": [
            {
                "name": "xuerong zheng",
                "org": ""
            },
            {
                "name": "zhengguo jin",
                "org": ""
            },
            {
                "name": "hui liu",
                "org": ""
            },
            {
                "name": "yueqiu wang",
                "org": ""
            },
            {
                "name": "xin wang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2013
    },
    "Bgqp5rY7": {
        "id": "Bgqp5rY7",
        "title": "A user-friendly heat-resistant modified polymer-based adhesive for joining and repair of carbon/carbon composites",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "xiaoxia hu",
                "org": ""
            },
            {
                "name": "xiqing xu",
                "org": ""
            },
            {
                "name": "ziqi yun",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            }
        ],
        "venue": "Materials & Design",
        "year": 2015
    },
    "bGjUZZeT": {
        "id": "bGjUZZeT",
        "title": "Well-dispersed, size-tunable chalcopyrite CuInSe 2 nanocrystals and its ink-coated thin films by polyhydric solution chemical process",
        "abstract": "Single-phase, near-stoichiometry and well-dispersed chalcopyrite CuInSe 2 nanocrystals were synthesized by a facile, ambient pressure solution chemical route using triethylene glycol as solvent, copper(II) chloride, indium(III) chloride and selenium powder as precursors. Crystallization, morphology, chemical stoichiometry and light property of the synthesized nanocrystals were characterized. Size dependence of the nanocrystals on different alkaline conditions, respectively adding sodium hydroxide, triethanolamine and ethylenediamine into reaction solutions was investigated. The synthesized nanocrystals were used to prepare ethanol-based colloidal inks and then deposit flat, dense and (112) oriented chalcopyrite thin films by layer-by-layer ink-dip-coating method and annealing at 550 °C in Ar. I-V characteristics of the PV devices with the ink-coated CuInSe 2 light-absorbing layer were measured. © 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "cuinse 2",
            "nanocrystalline materials",
            "solar cells",
            "teg solution synthesis",
            "thin films"
        ],
        "authors": [
            {
                "name": "Hui Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Weidong Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yueqiu Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Materials Letters",
        "year": 2012
    },
    "wQ9tSjNN": {
        "id": "wQ9tSjNN",
        "title": "Development of a buoyancy material of hollow glass microspheres/SiO2 for high-temperature application",
        "abstract": "Abstract   A type of buoyancy material with excellent temperature resistance was successfully prepared through a molding method, and the hollow glass microspheres (HGMs) and silicon oxide (SiO 2 ) were used as the filler and the matrix, respectively. The effect of sintering temperature on mechanical performance, microstructure, and high-temperature performance of the HGMs/SiO 2  composite were investigated in the study. The HGMs/SiO 2  composite exhibited low density (0.47–0.53 g/cm 3 ), high porosity (66.7–75.6%), low thermal conductivity (0.18–0.27 W/(m·K)), and relatively high compressive strength (3.8–5.2 MPa) properties. The values of Weibull moduli  m  used to predict the variation degree of compressive strength during the compression process was in the range of 5–15 and its values for the samples sintered at 850 °C was 14.64. Two stages namely elastic stage and fracture stage were shown in the stress-strain curves and in the elastic stage, the stress increased linearly with increasing of the strain until reaching the maximum stress. In the fracture stage, the sample gradually destroyed with further increasing of the strain until complete failure. The compressive strength of the HGMs/SiO 2  composites tested at high-temperature was larger than that of the one tested at room temperature. The HGMs/SiO 2  composite exhibited low density, low thermal conductivity and excellent temperature resistance properties and can be used as the structural material or buoyancy material in the deep sea field in the near future.",
        "keywords": "",
        "authors": [
            {
                "name": "Sue Ren",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haitao Ren",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Mingchao Wang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Liang Xian",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2017
    },
    "sg8sW4zD": {
        "id": "sg8sW4zD",
        "title": "A remarkable enhancement of formation of diamond-like carbon film from methane using dielectric-barrier discharges",
        "abstract": "The remarkable enhancement of production of diamond-like carbon film using CH4 and CO as co-feeds under the condition of dielectric-barrier discharges was studied. The presence of CO tended to induce the plasma polymerization from CH4 under the condition of dielectric-barrier discharges. The result of FTIR characteristics of plasma-polymerized film from CH4 and CO was presented.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yueping Zhang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yang Li.",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Baldur Eliasson",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Fei He",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Changjun Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "ACS Division of Fuel Chemistry, Preprints",
        "year": 2002
    },
    "s9OjZMPE": {
        "id": "s9OjZMPE",
        "title": "Influence of silica sources on morphology of mullite whiskers in Na2SO4 flux",
        "abstract": "The influence of crystalline form of silica on the morphology of mullite whiskers in Na 2 SO 4 flux was studied. Isolated mullite whiskers with 5 μm in average length were observed in the sample with amorphous and fused silica while clusters of mullite whiskers were obtained in the sample with quartz. Two distinct nucleation mechanisms were proposed to explain the morphology of the mullite whiskers.",
        "keywords": [
            "Ceramics",
            "Scanning electron microscopy",
            "Anisotropy",
            "Crystal growth",
            "X-ray diffraction"
        ],
        "authors": [
            {
                "name": "Pengyu Zhang",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Zhongqiu Li",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Shun Li",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Chao Chen",
                "org": "Key Lab of Advanced Ceramics and Machining Technology, College of Materials Science & Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "ptFWVEy6": {
        "id": "ptFWVEy6",
        "title": "Porous silica ceramics with relatively high strength and novel bi-modal pore structure prepared by a TBA-based gel-casting method",
        "abstract": "Porous silica ceramics with relatively high strength and novel bi-modal pore structure can be successfully fabricated via a facile tert-butyl alcohol-based gel-casting process by use of silica extracted from coal fly ash. Based on the evaporating of tert-butyl alcohol (TBA) during the drying process, the microstructure with bi-modal pores was obtained. By setting the solid loading (15 wt.%) and changing the sintering temperature from 1050 to 1150 °C, the porosity of the porous silica ceramics varied within the range of 70.1% and 72.4%, as the bulk density varied from 0.59 to 0.67 g/cm 3 and small pore sizes from 3.31 to 2.89 nm. The compressive strength of sintered silica ceramics increased from 4.38 MPa to 5.82 MPa, which was attributed to the 3D-framework structure and the connection of silica particles. © 2011 Elsevier Ltd and Techna Group S.r.l. All rights reserved.",
        "keywords": [
            "d. sio 2",
            "microstructure",
            "tba-based gel-casting"
        ],
        "authors": [
            {
                "name": "Hai Xu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Anran Guo",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguang Hou",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2012
    },
    "s6K3mJcY": {
        "id": "s6K3mJcY",
        "title": "Controllable synthesis of hierarchical porous mullite fiber network for gas filtration",
        "abstract": "Abstract   The hierarchical network was prepared by firing the mixture of mullite fiber and a kind of active powder which was made up of alumina gel, silica gel and AlF 3  powder. During which, the smooth surface of mullite fiber was coated with the secondary structure which was controllable by adjusting the firing temperature or by changing the mass ratio of active powder/mullite fiber. The secondary structure created new pore size distribution for the network. Some new pores with diameters of about 1 μm were found in the modified network, while the network constructed by the smooth mullite fiber only had pores with diameters of about 50 μm. Because of the introduction of the secondary structure, the particle filtration efficiency of the network substantially increased. The filtration efficiency for the 0.5 μm particles increased from 12.9% to 94.2%. The filtration efficiency for the 0.3 μm particles also increased from 0.6% to 56.6%.",
        "keywords": "",
        "authors": [
            {
                "name": "Qingzhao Liu",
                "org": "School of Materials Science and Engineering of Tianjin University, Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin 300072, China"
            },
            {
                "name": "Tao Xue",
                "org": "School of Materials Science and Engineering of Tianjin University, Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin 300072, China"
            },
            {
                "name": "Lina Yang",
                "org": "School of Materials Science and Engineering of Tianjin University, Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin 300072, China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "School of Materials Science and Engineering of Tianjin University, Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering of Tianjin University, Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin 300072, China"
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2016
    },
    "sBwgFNHf": {
        "id": "sBwgFNHf",
        "title": "Mechanical behavior of fibrous ceramics with a bird’s nest structure",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "guofa sui",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "sue ren",
                "org": ""
            },
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Composites Science and Technology",
        "year": 2014
    },
    "oOvYXc49": {
        "id": "oOvYXc49",
        "title": "Effects of fiber length and solid loading on the properties of lightweight elastic mullite fibrous ceramics",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "feng hou",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2015
    },
    "u82CMeYx": {
        "id": "u82CMeYx",
        "title": "Improved electrochemical performance of Li[Li0.2Mn0.54Ni0.13Co0.13]O2 by doping with molybdenum for Lithium battery",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiangyong du",
                "org": "tianjin university"
            },
            {
                "name": "zhongqiang shan",
                "org": "tianjin university"
            },
            {
                "name": "kunlei zhu",
                "org": "tianjin university"
            },
            {
                "name": "xiaoyan liu",
                "org": "tianjin university"
            },
            {
                "name": "jianhua tian",
                "org": "tianjin university"
            },
            {
                "name": "haiyan du",
                "org": "tianjin university"
            }
        ],
        "venue": "Journal of Solid State Electrochemistry",
        "year": 2014
    },
    "1DSIPrRr": {
        "id": "1DSIPrRr",
        "title": "Fine grained Al2O3–ZrO2 (Y2O3) ceramics by controlled crystallization of amorphous phase",
        "abstract": "Abstract   It is classic to prepare nanoceramics by crystallization of amorphous solids; however, this method was seldom reported in the classic system of Al 2 O 3 –ZrO 2 . In present work, fine grained Al 2 O 3 –ZrO 2  (Y 2 O 3 ) ceramics were obtained through controlled crystallization of dense amorphous bulks by heat treatment. Phase composition, microstructure and mechanical property were investigated during heat treatment. Crystallization and densification were almost completed after heat treatment at 1400 °C for 2 h with relative density of 98.5%, and as-prepared sample exhibited homogenous mixture of Al 2 O 3  and ZrO 2  grains at about 440 nm. The fine grained ceramic exhibited high hardness of 15.5 GPa and fracture toughness of 5.2 MPa m 1/2 . This work may provide new guidance for preparing AZY nanoceramics through crystallization of amorphous phase in both experiment and theory.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiqing Xu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China"
            },
            {
                "name": "Sue Ren",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China"
            },
            {
                "name": "Haitao Geng",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People’s Republic of China"
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2016
    },
    "1o1HJNhb": {
        "id": "1o1HJNhb",
        "title": "Double-layer gradient MoSi2-borosilicate glass coating prepared by in-situ reaction method with high contact damage resistance and interface bonding strength",
        "abstract": "Abstract   High emissivity coating is an important part of spacecraft thermal protection system. MoSi2-borosilicate glass coatings prepared by the in-situ reaction method showed excellent thermal endurance and oxidation resistance. However, radial cracks were prone to appear under external forces due to high cohesive of in-situ reaction dense coatings, and few studies focused on the mechanical properties of gradient coatings. In this study, a double-layer gradient MoSi2-borosilicate glass coating with a porous interface layer and a dense surface layer was prepared on mullite fibrous insulation tiles by in-situ reaction method. The double-layer gradient coating was compared with a mono-layer dense coating and a high-density gradient coating (another gradient coating with higher interface layer density) with reference to microstructure, contact damage resistance, interface bonding strength and thermal shock resistance. Compared with mono-layer dense coating and high-density gradient coating, double-layer gradient coating showed higher bearing capacity and avoided radial crack initiation and propagation in Hertzian indentation test. Besides, the double-layer gradient coating endured the most thermal shock cycles between 1500 °C and 20 °C and presented substrate fracture instead of interface fracture. In addition, double-layer gradient coating and high-density gradient coating possessed much higher interface bonding strengths than mono-layer dense coating. The total emissivities of three coatings were all greater than 0.87. The porous interface in double-layer gradient coating presented the advantages in enhanced mechanical and thermal compatibility between the in-situ reaction dense coating and substrate through reducing elastic modulus and thermal expansion coefficient differences.",
        "keywords": "",
        "authors": [
            {
                "name": "Xingyu Guan",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Xiaojing Xu",
                "org": "Systems Engineering Business Department, China Academy of Launch Vehicle Technology, Beijing, 100076, China"
            },
            {
                "name": "Wenhu Hong",
                "org": "Systems Engineering Business Department, China Academy of Launch Vehicle Technology, Beijing, 100076, China"
            },
            {
                "name": "Xin Tao",
                "org": "College of Science, Civil Aviation University of China, Tianjin, 300300, China"
            },
            {
                "name": "Jinyu Wu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300072, China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2020
    },
    "BxkwhM91": {
        "id": "BxkwhM91",
        "title": "Effects of adhesive composition on bond strength of green joined CePO4–ZrO2 ceramics",
        "abstract": "Green bodies of 25%CePO 4 /ZrO 2 and ZrO 2 ceramics were joined without applied pressure using mixed powders slurries composed of CePO 4 and ZrO 2 . The effects of CePO 4 /(CePO 4 + ZrO 2 ) ratio of the adhesive on the bond strength of the joints and the microstructure of the joints were investigated. Keywords Green body Slurries Strength Joint Interface",
        "keywords": [
            "Green body",
            "Interface",
            "Joint",
            "Slurries",
            "Strength"
        ],
        "authors": [
            {
                "name": "Hai Gao",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, 2001 Yan, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, 2001 Yan, Tianjin 300072, China"
            },
            {
                "name": "Mingzheng Liu",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, 2001 Yan, Tianjin 300072, China"
            },
            {
                "name": "Weirong Huo",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, 2001 Yan, Tianjin 300072, China"
            },
            {
                "name": "Lijuan Wang",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, 2001 Yan, Tianjin 300072, China"
            }
        ],
        "venue": "Scripta Materialia",
        "year": 2003
    },
    "NRLEDqyk": {
        "id": "NRLEDqyk",
        "title": "Ternary and quaternary chalcopyrite Cu(In1-xGa x)Se2 nanocrystals: Organoalkali-assisted diethylene glycol solution synthesis and band-gap tuning",
        "abstract": "In this work, four organoalkali-assisted diethylene glycol solution chemical syntheses, using triethylenetetramine, ethanediamine, N,N-dimethylformamide and triethanolamine as assisting agents, CuCl 2·2H2O, InCl3·4H2O, GaCl3 and Se powder as precursors, N2H4· H2O as the reductant and polyvinylpyrrolidone as the dispersant, were applied to prepare ternary and quaternary chalcopyrite CuIn 1-xGaxSe2 nanocrystals (0 ≤ x ≤ 1). The synthesized products were characterized by XRD, TEM, FESEM, EDX, ICP-MS, Raman, and UV-vis-IR measurements. The dynamic concentrations of fed solutions with reaction time were qualitatively described under non-organoalkali-assisted and organoalkali-assisted conditions. The organoalkali-assisted effects were discussed according to the different alkaline intensity and chelating ability to the monomer precursor species. Chemical stoichiometry control and band-gap tuning of the synthesized ternary and quaternary chalcopyrite CuIn 1-xGaxSe2 nanocrystals were investigated by simply changing In/Ga atomic ratios of the fed solutions in the diethylene glycol based solution process with the optimized triethylenetetramine-assisted amounts. The results showed that the triethylenetetramine-assisted diethylene glycol solution synthesis was a facile and effective way to control the chemical stoichiometry and band-gap energies for single-phase, well-dispersed, near-granular shaped CuIn1-xGaxSe2 nanocrystals with a size range of 10 nm-20 nm. This journal is © 2013 The Royal Society of Chemistry.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jia Li",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Tong Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jian Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Dalong Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Junyun Lai",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Lan Cui",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "CrystEngComm",
        "year": 2013
    },
    "Kugim6xc": {
        "id": "Kugim6xc",
        "title": "The Study of Microwave Joint Interface of ZrO_2 Toughened Ceramic",
        "abstract": "A series of study was conducted on the microwave joint interface of two kind of ZrO2 toughened ceramic,including joint experiment parameter,microstructure of joint interface,interfacial element diffusion and so on.The results showed: the experiment parameter,including the preparation method of base material,the content of solid state material in the lurry interlayer,the heating process and so on,could make important impact on the joint interface;the inter-diffusion of elements between base material and the interlayer was the base of fine joint result.The joining processes were successfully conducted under low energy of 1000 W to 3000 W in short time,indicating the advantage of microwave joining on time and energy reduce.",
        "keywords": [
            "Microwave joining",
            "Joint interface",
            "Diffusion",
            "ZTM",
            "Microstructure",
            "ZTA"
        ],
        "authors": [
            {
                "name": "LI Sha",
                "org": "Tianjin University,Key Laboratory of Advanced Ceramics and Machining Technology,Ministry of Education,Tianjin ,China"
            },
            {
                "name": "FAN Wei",
                "org": "Tianjin University,Key Laboratory of Advanced Ceramics and Machining Technology,Ministry of Education,Tianjin ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Tianjin University,Key Laboratory of Advanced Ceramics and Machining Technology,Ministry of Education,Tianjin ,China"
            },
            {
                "name": "LIU Jia-chen",
                "org": "Tianjin University,Key Laboratory of Advanced Ceramics and Machining Technology,Ministry of Education,Tianjin ,China"
            }
        ],
        "venue": "Vacuum Electronics",
        "year": 2009
    },
    "OozAFblg": {
        "id": "OozAFblg",
        "title": "Synthesis and Characterization of Ultra-Fine Si3N4 by Electric Arc Plasma",
        "abstract": "",
        "keywords": [
            "raw materials",
            "x ray diffraction",
            "transmission electron microscopy",
            "particle size",
            "x ray photoelectron spectroscopy",
            "nitrogen"
        ],
        "authors": [
            {
                "name": "zou jijun",
                "org": "tianjin university"
            },
            {
                "name": "gheorghi p vissokov",
                "org": "bulgarian academy of sciences"
            },
            {
                "name": "he fei",
                "org": "tianjin university"
            },
            {
                "name": "liu changjun",
                "org": "tianjin university"
            },
            {
                "name": "du haiyan",
                "org": "tianjin university"
            },
            {
                "name": "cui lan",
                "org": "tianjin university"
            }
        ],
        "venue": "Plasma Science & Technology",
        "year": 2002
    },
    "X36SymTV": {
        "id": "X36SymTV",
        "title": "Repairing cracks in ceramics",
        "abstract": "Using SiC, Al, Al2O3 and Y2O3 as raw materials, based on chemical reactions those can cause expansion effect at elevated temperature among them, such as Al oxidizes to Al2O 3 and SiC converts to SiO2, a sort of ceramic that can be used to repair macroscopic cracks of sintered ceramics was prepared. Two reaction productions can react further to form mullite (3Al2O 3 · 2SiO2) at temperature > 1400°C, which accompanied with a volume expansion also. The total expanding extent can be adjusted by proportion of raw materials or control of sintering temperature. Filling this expandable ceramic ingredient in cracks of sintered ceramic in a designed slurry state, cracks could be repaired by a re-sintering process.",
        "keywords": [
            "Ceramic",
            "Crack repairing",
            "Expansion",
            "Slurry"
        ],
        "authors": [
            {
                "name": "Tiecheng Feng",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Shun Li",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            }
        ],
        "venue": "Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering",
        "year": 2005
    },
    "dFtOo5Jq": {
        "id": "dFtOo5Jq",
        "title": "Evaluation of metastable degree in amorphous Al2O3-ZrO2-Y2O3 and its effect on plastic deformation",
        "abstract": "Abstract   Novel plastic deformation was exhibited in amorphous oxides, attributed to the metastable state of amorphous phase with free volume and disordering structure; however, metastable degrees can be quite different in amorphous phases, and the effect of metastability on plastic deformation was never reported in amorphous oxides. In this work, the metastable degree of amorphous phase was controlled by adjusting the temperature in powder calcination, and evaluated through free volume and disordering degree, using the true density of amorphous powder, DSC and  27 Al MAS-NMR. Under compression at 500 °C, the sample with lowest metastability exhibited brittle fracture; however, the other two with higher metastable degrees displayed plastic strain of 3.5% and 5.2%. The enhanced plastic deformation benefited from higher metastability was mainly attributed to easier formation of shear bands. For amorphous phase with higher metastability, the atomic mobility and local free volume were larger, which could improve the formation of shear bands and promote the plasticity according to free volume theory. This work could inspire new methods to improve the plastic deformation in amorphous materials.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiqing Xu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Zheng Gong",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Feng Hou",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2017
    },
    "aMGWOASk": {
        "id": "aMGWOASk",
        "title": "Well-Dispersed, Plate-Shaped Cu 2– x Se Nanocrystals by Ambient-Pressure Trithylene Glycol-Based Solution Synthesis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lan cui",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "xuerong zheng",
                "org": ""
            },
            {
                "name": "yueqiu wang",
                "org": ""
            },
            {
                "name": "hui liu",
                "org": ""
            },
            {
                "name": "zhengguo jin",
                "org": ""
            },
            {
                "name": "xin wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "FssCmpyJ": {
        "id": "FssCmpyJ",
        "title": "TiO2 thin films prepared by liquid phase deposition on the optical fiber",
        "abstract": "Titanium oxide thin films on the optical fiber with photocatalytic activities were prepared via liquid phase deposition method by adding H 3BO3 into an (NH4)2TiF6 solution supersaturated with anatase nano-crystalline TiO2 at 40°C. Dried at room temperature and annealed at different temperature to remove the volatile substance, uniform thin films were successfully prepared on optical fiber. Film thickness and particle size were controlled by the deposition times and heat treatment. The effects of the deposition condition on the structure, surface morphology, thickness and heat treatment of the TiO 2 thin films were studied by XRD, SEM methods.",
        "keywords": [
            "LPD",
            "Nano titanium",
            "Optical fiber",
            "Thin films"
        ],
        "authors": [
            {
                "name": "Shun Li",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Boran Tian",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Xiyou Jinshu Cailiao Yu Gongcheng/Rare Metal Materials and Engineering",
        "year": 2005
    },
    "0LgCDdrh": {
        "id": "0LgCDdrh",
        "title": "Morphological growth and phase formation of CuInSe 2 nanocrystals by an ambient pressure polylol-based solution synthesis",
        "abstract": "Single-phase and well-dispersed CuInSe 2 nanoparticles and nanoplates were successfully synthesized through an ambient pressure solution chemical process using green triethylene glycol (TEG) as solvent, copper(ii) chloride, indium(iii) chloride and selenium powder as precursor sources. Morphological growth of the CuInSe 2 nanoparticles and nanoplates synthesized respectively with the hydrazine- and ethylenediamine-assisted TEG reaction solution was investigated by XRD, TEM, HRTEM, SAED, XPS and EDX analysis. The results showed that the growth process of CuInSe 2 nanoparticles derived from the hydrazine-assisted solution only underwent quick reduction reaction of elemental Se to Se 2- and cupric Cu 2+ to Cu + to directly form the ternary compound. The growth of CuInSe 2 nanoplates derived from the ethylenediamine-assisted solution involved in the formation of intermediate phase CuSe with lamellar morphology and subsequently a transformation of the CuSe phase into CuInSe 2 phase by gradual reduction of cupric Cu 2+ to cuprous Cu +, In 3+ and active Se 2- participation at growing lattice sites. © 2012 The Royal Society of Chemistry.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Hui Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Xin Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Xuerong Zheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yueqiu Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Lan Cui",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "CrystEngComm",
        "year": 2012
    },
    "7SkUCgmT": {
        "id": "7SkUCgmT",
        "title": "Synthesis and properties of lightweight fibrous ceramics with a 3D skeleton structure prepared by infiltration",
        "abstract": "",
        "keywords": [
            "fracture",
            "microstructure",
            "infiltration"
        ],
        "authors": [
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "hanyu lv",
                "org": ""
            },
            {
                "name": "guofa sui",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "xin tao",
                "org": ""
            },
            {
                "name": "xiqing xu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Science and Engineering A-structural Materials Properties Microstructure and Processing",
        "year": 2015
    },
    "hVbJvBti": {
        "id": "hVbJvBti",
        "title": "Microstructure, optical and optoelectrical properties of mesoporous nc-TiO2 films by hydrolysis-limited sol–gel process with different inhibitors",
        "abstract": "Mesoporous nanocrystalline titania (nc-TiO 2 ) films were synthesized by sol–gel route using poly (alkylene oxide) block copolymer as template and tetrabutyl orthotitanate as titanium source. Influence of acetylacetone (AcAc), glacial acetic acid, HCl and AcAc-HCl as inhibitors on hydrolysis/condensation reaction was investigated. The mesopore structure, crystalline phase and optical characteristics were analyzed by N 2 adsorption, X-ray diffraction, transmission electron microscopy and UV–VIS–NIR spectrum. Photoaction measurements were performed on dye-sensitized solar cells (DSSCs) using the mesoporous nc-TiO 2 as photoanodes. The results show that the formed films are anatase phase and mesoporous structure. Different restraining mechanisms of these inhibitors to hydrolysis/condensation process lead to different mesoporous structure whose specific surface area (S BET ) varies from 34 to 176 m 2 /g, and crystal size is from 5.6 to 38.2 nm. The mesoporous photoanode with high S BET and large crystalline grains may be responsible for increasing conversion efficiency of the DSSCs.",
        "keywords": [
            "Sol–gel",
            "Hydrolysis reaction",
            "Mesopore",
            "Triblock copolymer",
            "Titania"
        ],
        "authors": [
            {
                "name": "Yanan Fu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials, Tianjin University, 300072 Tianjin, China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "tianjin university"
            },
            {
                "name": "Yong Ni",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials, Tianjin University, 300072 Tianjin, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Analysis Center, Tianjin University, 300072 Tianjin, China"
            },
            {
                "name": "Tao Wang",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials, Tianjin University, 300072 Tianjin, China"
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2009
    },
    "F6imhQE2": {
        "id": "F6imhQE2",
        "title": "Investigation of Microstructure of Al_2O_3/LaPO_4 Ceramic Composites",
        "abstract": "Layer structured LaPO_4 was added to Al_2O_3 ceramic matrix to improve the machinability of the composites. Microstructures of the Al_2O_3/LaPO_4 ceramic composites were studied at various sintering temperatures (1450, 1520, 1580, 1700 ℃) and different LaPO_4 contents (pure Al_2O_3, 30% LaPO_4, 50% LaPO_4, 70% LaPO_4, pure LaPO_4). Microstructures of the Al_2O_3/LaPO_4 composites are largely dependent on the LaPO_4 content and sintering temperature. X-ray diffraction analysis shows that LaPO_4 phase would not exist in the Al_2O_3/LaPO_4 composites when sintered above 1700 ℃.",
        "keywords": [
            "Al_2O_3",
            "microstructure",
            "LaPO_4",
            "machinable"
        ],
        "authors": [
            {
                "name": "Zhu Yufeng",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin , China"
            },
            {
                "name": "Liu Jiachen",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin , China"
            },
            {
                "name": "Liu Haiyan",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin , China"
            },
            {
                "name": "Du Haiyan",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2005
    },
    "bkXTZ3eJ": {
        "id": "bkXTZ3eJ",
        "title": "Preparation and formation mechanism of porous TiO2 films using PEG and alcohol solvent as double-templates",
        "abstract": "Porous nanocrystalline TiO2 anatase thin films have been synthesized on glass substrates via a sol-gel dip-coating method. The coating sol was obtained by suppressed hydrolysis of Ti(OC4H9)4 through the addition of complexing molecules as stabilizers in an alcohol solution containing polyethylene glycol (PEG). Chemical changes taking place during the sol-gel process were discussed based on IR spectra analysis. A model concerning the pore formation was established to explain the role of PEG and solvent with core-shell configuration as double-templates. The structural characteristics of porous TiO2 films were found to greatly depend on the concentration and molecular weight of PEG, the types of stabilizing agents and solvents. The pore size of the films was tunable in the range of 10–500 nm and their surface area varied from 51 to 72 m2·g-1.",
        "keywords": [
            "TiO",
            "2",
            "porous thin films",
            "double-templates",
            "polyethylene glycol",
            "mechanism"
        ],
        "authors": [
            {
                "name": "Shaojing Bu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Xiaoxin Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "ZhiJie Cheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Journal of Sol-Gel Science and Technology",
        "year": 2004
    },
    "Hywj9w1Y": {
        "id": "Hywj9w1Y",
        "title": "Silica/mullite fiber composite membrane with double-layer structure for efficient sub-micrometer dust removal",
        "abstract": "Abstract   Here, we developed silica/mullite fiber composite membranes with double-layer structure by a simple vacuum procedure for the removal of sub-micrometer dust. The support with three-dimensional skeleton structure exhibited high porosity (higher than 90%), low density (lower than 0.25 g/cm 3 ) and high compressive strength (higher than 0.55 MPa) at 1000 °C. By controlling the mass ratio of silica sol to mullite fiber, we can obtain uniform and complete filtering layers with different thicknesses. The composite membranes exhibited high PM filtration efficiency with 99% for 1–10 µm, 97% for 0.5 µm and 90% for 0.3 µm. These samples had high air flow with very low pressure drop (lower than 600 Pa when airflow velocity reached 1 m/s). These results indicated that the silica/mullite fiber composite membranes were very promising for PM pollution control in the field of hot gas filtration.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenjie Wang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Lingyu Li",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Wei Jing",
                "org": "Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900, China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2019
    },
    "Au8tMseL": {
        "id": "Au8tMseL",
        "title": "Microstructure of mullite fiber-based hierarchical structures adjusted by Al/Si mole ratio of the raw material powders",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shan liu",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "feng hou",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2014
    },
    "HtlTTvOQ": {
        "id": "HtlTTvOQ",
        "title": "Highly efficient Pt/TiO2 photocatalyst prepared by plasma-enhanced impregnation method",
        "abstract": "Highly efficient Pt/TiO 2 photocatalyst has been prepared using plasma-enhanced impregnation method. Impregnated 0.5 wt%Pt/TiO 2 was treated by plasma followed with thermal calcinations and hydrogen reduction. The catalyst characterizations show that Pt is highly dispersed with a size of 3–5 nm. UV–Vis reflection spectrum suggests it a high photosensitivity in near UV region. Such plasma prepared catalyst exhibits a much higher activity and better metal stability for hydrogen generation from methanol/water mixture, compared to the catalyst prepared conventionally. This highly efficient photocatalyst should have extensive applications in photocatalytic processes.",
        "keywords": [],
        "authors": [
            {
                "name": "Ji-Jun Zou",
                "org": "Key Laboratory for Green Chemical Technology, School of Chemical Engineering and Technology, Tianjin University, PO Box 796666, Tianjin 300072, China"
            },
            {
                "name": "Chang-Jun Liu",
                "org": ""
            },
            {
                "name": "Kai-Lu Yu",
                "org": "Key Laboratory for Green Chemical Technology, School of Chemical Engineering and Technology, Tianjin University, PO Box 796666, Tianjin 300072, China"
            },
            {
                "name": "Dang-Guo Cheng",
                "org": "Key Laboratory for Green Chemical Technology, School of Chemical Engineering and Technology, Tianjin University, PO Box 796666, Tianjin 300072, China"
            },
            {
                "name": "Yue-Ping Zhang",
                "org": "Department of Chemistry, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Fei He",
                "org": "Key Laboratory for Green Chemical Technology, School of Chemical Engineering and Technology, Tianjin University, PO Box 796666, Tianjin 300072, China"
            },
            {
                "name": "Hai-Yan Du",
                "org": "Analysis Center, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Lan Cui",
                "org": "Analysis Center, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Chemical Physics Letters",
        "year": 2004
    },
    "6W3yCl61": {
        "id": "6W3yCl61",
        "title": "Silicon Carbide whiskers reinforced polymer-based adhesive for joining C/C composites",
        "abstract": "Abstract   The strengthening and toughening effect of SiCw and CNTs for a heat-resistant polymer-based adhesive is respectively compared at first. SiCw and CNTs show similarly optimum strengthening performance when their content in the resin is 0.75 wt% and 0.3 wt%, respectively, while the toughening performance provided by 0.75 wt% SiCw is obviously better than that provided by 0.3 wt% CNTs. For 0.75 wt% SiCw-added adhesive, SiCw shows various strengthening and toughening effect after the adhesive is calcined at different temperatures, attributing to the variation of adhesiveu0027s composition and structure in the heating process. After calcination at 1300 °C, the strengthening and toughening rate of the adhesive during the room-temperature test is up to 22.6% and 36.9%, respectively. Also, for 1300 °C-calcined adhesive, SiCw still provides sound reinforcing effect during the high-temperature test when the temperature is not above 700 °C. However, SiCw almost loses its strengthening and toughening effect when the testing temperature is above 700 °C as newly-formed borosilicate glass melts in adhesive at the temperature above 700 °C.",
        "keywords": "",
        "authors": [
            {
                "name": "Mingchao Wang",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Ran Miao",
                "org": ""
            },
            {
                "name": "Junkai He",
                "org": ""
            },
            {
                "name": "Xiqing Xu",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Materials & Design",
        "year": 2016
    },
    "RVQ13jIQ": {
        "id": "RVQ13jIQ",
        "title": "Highly efficient Pt/TiO2 photocatalyst for hydrogen generation prepared by a cold plasma method",
        "abstract": "A glow discharge plasma treatment was used to modify the impregnation method to prepare Pt / TiO2 photocatalysts with the following steps: impregnation, cold plasma treatment, calcination, and reduction. The activity and properties of the catalysts were studied in comparison with those prepared with traditional impregnation method. The activities for hydrogen generation from water/alcohols mixtures were significantly promoted. The properties including the metal dispersion, near-UV absorption, and metal stability were also enhanced. The enhanced metal dispersion and optical absorption partly promoted the activity but the effect was limited. It was speculated that the plasma method produced an enhanced metal-support interaction. According to high-resolution TEM observation, a greatly distorted metal-support interface was formed on the plasma prepared catalyst. This interface allowed a close contact between the metal atoms and support lattices, which supported the existence of the enhanced interaction. This interface was expected to facilitate the electron transfer during photocatalytic reaction and be the major reason for the high activity of the plasma prepared photocatalysts. © 2006 International Association for Hydrogen Energy.",
        "keywords": [
            "glow discharge plasma",
            "hydrogen generation",
            "metal-support interface",
            "pt / tio2",
            "high resolution",
            "electron transfer"
        ],
        "authors": [
            {
                "name": "Ji-Jun Zou",
                "org": ""
            },
            {
                "name": "Hei He",
                "org": "Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Lan Cui",
                "org": "Analysis Center, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Hai-Yan Du",
                "org": "Analysis Center, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "International Journal of Hydrogen Energy",
        "year": 2007
    },
    "1Z7eFVC0": {
        "id": "1Z7eFVC0",
        "title": "Growth and characterization of CuInSe 2 thin films prepared by successive ionic layer adsorption and reaction method with different deposition temperatures",
        "abstract": "",
        "keywords": [
            "cycle time",
            "crystal structure",
            "reaction kinetics",
            "thin film",
            "surface roughness",
            "band gap"
        ],
        "authors": [
            {
                "name": "jingxia yang",
                "org": ""
            },
            {
                "name": "zhengguo jin",
                "org": ""
            },
            {
                "name": "yating chai",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "tongjun liu",
                "org": ""
            },
            {
                "name": "tao wang",
                "org": ""
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2009
    },
    "uprZm072": {
        "id": "uprZm072",
        "title": "CuInSe 2 , CuGaSe 2 and Cu(In, Ga)Se 2 nanocrystals synthesized by ambient pressure diethylene glycol based solution process",
        "abstract": "",
        "keywords": [
            "nanocrystals"
        ],
        "authors": [
            {
                "name": "yueqiu wang",
                "org": ""
            },
            {
                "name": "zhengguo jin",
                "org": ""
            },
            {
                "name": "hui liu",
                "org": ""
            },
            {
                "name": "xin wang",
                "org": ""
            },
            {
                "name": "xuerong zheng",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Powder Technology",
        "year": 2012
    },
    "xz9DVuob": {
        "id": "xz9DVuob",
        "title": "A new practical inorganic phosphate adhesive applied under both air and argon atmosphere",
        "abstract": "",
        "keywords": [
            "ceramics",
            "heat treatment",
            "adhesion"
        ],
        "authors": [
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "feng hou",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "yingna zhao",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2014
    },
    "RiNYhmYR": {
        "id": "RiNYhmYR",
        "title": "Fabrication of fly ash cenospheres-hollow glass microspheres/borosilicate glass composites for high temperature application",
        "abstract": "Abstract   A temperature resistant buoyant material, namely, fly ash cenospheres-hollow glass microspheres/borosilicate glass (FACs-HGMs/BG) for high temperature application, was prepared through a tert-butyl alcohol-based gelcasting process, with FACs and HGMs as the fillers and BG as the matrix, respectively. The effect of FACs addition on the mechanical and high-temperature performance of the FACs-HGMs/BG composites was studied. The composites containing different amounts of FACs displayed low density (0.44–0.89 g/cm 3 ), low Youngu0027s modulus (0.05–1.10 GPa), and relatively high compressive strength (2.78–9.75 MPa). Three stages, namely, elastic, plateau, and fracture stages, could be observed in the stress-strain curves. The compressive strength of the samples at high temperature was lower than the ones at room temperature, and the 10%FACs-HGMs/BG composite tested at 500 °C displayed a compressive strength of 6.03 MPa. The FACs-HGMs/BG composites demonstrating excellent mechanical properties both at room and high temperatures may be used as promising candidates for structural materials or temperature resistant buoyant materials in the near future.",
        "keywords": "",
        "authors": [
            {
                "name": "Sue Ren",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            },
            {
                "name": "Sue Ren",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            },
            {
                "name": "Sue Ren",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            },
            {
                "name": "Xin Tao",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xiaohui Ma",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jun Xu",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            },
            {
                "name": "Jun Liang",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            },
            {
                "name": "Shaohua Chen",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            },
            {
                "name": "Jingran Ge",
                "org": "Institute of Advanced Structure Technology, Beijing Institute of Technology, Beijing 100081, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2018
    },
    "05Lc7ofo": {
        "id": "05Lc7ofo",
        "title": "Mullite fiber sealing pad with favorable high-temperature rebound resilience fabricated through colloidal processing",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "sibo shen",
                "org": ""
            },
            {
                "name": "yingna zhao",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "lan zhao",
                "org": ""
            },
            {
                "name": "geng tian",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2014
    },
    "Nu2CzjyO": {
        "id": "Nu2CzjyO",
        "title": "Joining of C/C composites by using B 4 C reinforced phosphate adhesive",
        "abstract": "",
        "keywords": [
            "heat treatment"
        ],
        "authors": [
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "feng hou",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "shan liu",
                "org": ""
            },
            {
                "name": "xue dong",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2014
    },
    "brJ269rm": {
        "id": "brJ269rm",
        "title": "Influence of silica sources on morphology of mullite whiskers in Na 2 SO 4 flux",
        "abstract": "",
        "keywords": [
            "scanning electron microscopy",
            "ceramics",
            "crystal growth",
            "anisotropy",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "pengyu zhang",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "zhongqiu li",
                "org": ""
            },
            {
                "name": "shun li",
                "org": ""
            },
            {
                "name": "chao chen",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "Y1rXmC37": {
        "id": "Y1rXmC37",
        "title": "Mechanical properties and thermal conductivity of a temperature resistance hollow glass microspheres/borosilicate glass buoyance material",
        "abstract": "Abstract   A temperature resistance buoyancy material was fabricated through a tert-butyl alcohol gelcasting process with borosilicate glass (BG) and hollow glass microspheres (HGMs) as the matrix and filler, respectively. The effects of the mass ratio of HGMs to BG and sintering temperature on the microstructure, thermal conductivity, and mechanical properties of the composite were studied. The results show that HGMs were bonded together by the BG, and the sample sintered at 750 °C exhibited a broad pore size distribution, from several microns to more than one hundred microns. The thermal conductivity experimental values of all the samples were less than that of Hashin-Shtrikman upper bound (HS + ) prediction but agreed well with that predicted from effective medium percolation theory. The relationship between compressive strength and relative density was predicted by the Gibson-Ashby model, with the calibration factor phi below 0.7. Young′s modulus values obtained from the experiment were below that of HS +  prediction. The modulus values of the four types of samples sintered at 650 °C agreed well with the Pabst model prediction, while the values of the samples sintered at 700 °C and 750 °C were distributed in a zone between Ashby-Gibson model and HS +  prediction.",
        "keywords": "",
        "authors": [
            {
                "name": "Sue Ren",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Wenjie Zang",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haitao Geng",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xin Tao",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Materials Science and Engineering A-structural Materials Properties Microstructure and Processing",
        "year": 2016
    },
    "rOy1Xp0z": {
        "id": "rOy1Xp0z",
        "title": "A facile preparation of mullite [Al2(Al2.8Si 1.2)O9.6] nanowires by B2O3-doped molten salts synthesis",
        "abstract": "Al-rich single-crystal mullite [Al2(Al2.8Si 1.2)O9.6] nanowires were prepared by B2O 3-doped molten salts synthesis. The nanowires have diameters in the range 30-50 nm and typical lengths of 1 μm. The mullite nanowires were well dispersed and facile to obtain. © 2010 The Royal Society of Chemistry.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Pengyu Zhang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Sha Li",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Rui Xu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Chemical communications (Cambridge, England)",
        "year": 2010
    },
    "sR52Z9mM": {
        "id": "sR52Z9mM",
        "title": "Thermal shock resistance of dense zirconia matrix composites evaluated by indentation techniques",
        "abstract": "The thermal shock behavior of 3Y-TZP/LaPO 4 composites containing 0, 15, 30 vol.% LaPO 4 was evaluated with an indentation-quench method based on propagation of Vickers cracks. The effect of LaPO 4 particle size on the thermal shock behavior of 3Y-TZP/LaPO 4 composites was investigated preliminarily. Results showed that the composite containing 15 vol.% 900 °C sintered LaPO 4 exhibited better resistance to crack propagation and thermal shock under water quenching condition. Larger grain size or higher content of LaPO 4 would deteriorate the thermal shock resistance of 3Y-TZP/LaPO 4 composites. The calculation of thermal shock resistance parameter R st for the composites gives a possible explanation for the difference in thermal shock behavior. Keywords 3Y-TZP Lanthanum phosphate Indentation-quench Thermal shock resistance 1 Introduction In recent years, zirconia ceramics has attracted more and more attention as a high-technology material for industrial applications due to its excellent mechanical properties at room and moderate temperature, high hardness, wear resistance and chemical stability. However, the poor thermal shock resistance, resulting from the high thermal expansion coefficient and low thermal conductivity, to a great extent, has limited the application of zirconia ceramics. Increased thermal shock resistance can be achieved either by making it more difficult for cracks to initiate or by limiting the extent to which they can grow once cracking has started [1,2] . Obtaining useful improvements to the thermal shock resistance by preventing the initiation of cracks are difficult, particularly when the thermal shock is severe, as the crack driving forces can be many orders of magnitude greater than the resistance to fracture of ceramic materials. It is therefore more usual to try to limit the extent of crack propagation. This requires either that as much energy as possible be dissipated in growing the crack, or that the crack driving force available to each individual crack be reduced. For zirconia ceramics, this can be achieved often by increasing the porosity in the material [3] . But the increased porosity often lead to a degradation in properties such as corrosion resistance, which can be of primary importance where zirconia ceramics are required for the handling of molten metal and glass [4,5] . An alternative approach is to incorporate a ductile particulate second phase into dense zirconia matrix. Many studies have shown that the incorporation of a ductile particulate second phase into dense ceramic matrix (e.g., molybdenum in zirconia or alumina [6,7] , iron, copper, Fe 3 Al, tungsten carbide in alumina [8–11] , h-BN in SiC [12] or zirconia [13] ) can lead to an enhanced thermal shock resistance. The mechanisms of crack shielding and blunting and crack deflection have a large effect on improving the thermal shock resistance of those composites. While these composites have higher thermal shock resistance, the usefulness of them is limited by their sensitivity to oxidation. Rare earth phosphate (e.g., LaPO 4 , CePO 4 ) is a class of “ductile” material with layered structure. They were found stable to very high temperature (>1600 °C) in an oxidizing environment and suitable to fabricate composites with refractory oxide (e.g., Al 2 O 3 , ZrO 2 , or mullite) [14] . Studies have shown that the bonding between these phosphates and oxides is weak [15,16] . Mechanisms like crack blunting, branching and deflection that can prohibit main-crack growth should easily occur at the weak bonding interfaces between the two phases. Based on this theory, it was expected that the thermal shock resistance can be improved without compromising the excellent properties of dense zirconia ceramics by adding LaPO 4 particles. In our previous work [17] , it was found that the presence of monazite LaPO 4 had a positive effect on the thermal shock resistance of LaPO 4 –ZrO 2 composites. In this paper, the effect of LaPO 4 content and particle size on the thermal shock resistance of dense 3Y-TZP/LaPO 4 composites was investigated using indentation-quench method, and the growth behavior of thermal shock induced crack was further studied. 2 Experimental procedure 2.1 Materials Commercial available 3Y-TZP (99%, 0.3 μm, Zibo rare earth material Co. Ltd., Shandong, China) and LaPO 4 ·0.5H 2 O (99%, Zibo rare earth material Co. Ltd., Shandong, China) powders were used as the starting materials. In order to obtain LaPO 4 with different crystal size, the starting LaPO 4 powder was divided into two parts and calcined at 900 °C and 1250 °C for 1 h, respectively. The calcined powders were grinded and sieved through an 80 mesh before use. The specific surface area (BET method, NOVA 2000) of the two calcined powders was 2.32 m 2 /g and 0.77 m 2 /g, and the corresponding average particle size was 13 μm and 40 μm, respectively. Accordingly, they were named “fine LaPO 4 ” (900 °C) and “coarse LaPO 4 ” (1250 °C), respectively. A monolithic 3Y-TZP and three 3Y-TZP/LaPO 4 composites (containing 15 vol.% coarse LaPO 4 , 15 vol.% and 30 vol.% fine LaPO 4 , respectively)—designated as Z15L C , Z15L F , Z30L F , were fabricated by slip casting. Tap water was used as a dispersing medium and 5 vol. % (based on the volume of water) ammonium polyacrylate ( M ¯ w = 1000 , Hengsheng Chemical Co. Ltd., Shanghai, China) was chosen as a dispersant. Slurries with solid loading of 71 wt.% were then prepared by ball milling for 8 h in nylon pots with high purity zirconia balls. After degassing, slip casting was performed using gypsum moulds. The green samples were dried in an over at 50 °C for 24 h, and then pressureless-sintered in air at 1450 °C for 2 h. 2.2 Microstructure and mechanical properties The relative density of the sintered specimens was measured using the Archimedes displacement method with distilled water. Sintered specimens for flexural strength test were machined into bars with dimensions of 25 mm × 5 mm × 2.5 mm, and the top and bottom surfaces were ground flat and polished by standard diamond polishing techniques down to 10 μm. The flexural strength of the specimens was tested using a conventional three point flexural method, with a span of 20 mm and a cross-head speed of 0.368 mm/min. Measurements were performed on at least five test bars of each material. Hardness (Hv) and fracture toughness ( K IC ) at room temperature were determined from Vickers indentation tests (HV-10 Vickers hardness tester) on polished surfaces with indentation loads of 98 N and 196 N during times of 15 s, respectively. No chipping associated with any indentation was detected, and the indentations that exhibited secondary radial cracking were rejected. The principal diagonals of the plastically deformed zone and the length of the radial cracks were measured using the optical microscopy equipped on HV-10 Vickers hardness tester. The equation proposed by Niihara [18] was used to calculate the K IC . Reported Hv and K IC values are the average of ten determinations and errors are the standard deviations. XRD analysis was carried out using Rigaku D/max 2500 v/pc X-ray diffractometer (Cu/Kα, Ni filter). The volume fraction of the m-ZrO 2 ( V m ) was calculated by measuring the intensities of (1 1 1) and ( 1 ¯   1   1 ) reflections of the monoclinic phase and the (1 1 1) peak of the tetragonal phase according to the formula of Toraya et al. [19] : (1) V m = 1.311 X m 1 + 0.311 X m (2) X m = I m ( 1   1   1 ) + I m ( 1 ¯   1   1 ) I m ( 1   1   1 ) + I m ( 1 ¯   1   1 ) + I t ( 1   1   1 ) where X m denotes the integrated intensity ratio, I m and I t are the peak intensities of the m-ZrO 2 and t-ZrO 2 , respectively. Microstructure characterization was by scanning electron microscopy (Philips XL-30) on fracture surfaces and on polished and thermally etched (1400 °C/45 min) surfaces (after ultrasonic cleaning with acetone and dried). 2.3 Thermal shock measurements Thermal shock tests were conducted on small discs with 4 mm in thickness that was cut from cylindrical bars of 11.5 mm diameter. They were ground and polished successively with 1000# and 2000# sandpaper and final polishing was carried out with a diamond paste of 0.5 μm. The specimens were indented using HV-10 Vickers hardness tester. The indentation load 98 N was chosen so that indentation crack sizes in the range 100–150 μm were achieved for each material. This size of the pre-racks was chosen according to the study of Pettersson et al. [20] . Four indents were made on each sample and uniformly distributed on a circle with radius of 6 mm. Each indent generated four cracks, so that 16 cracks were made on each sample. Measurements were performed on three samples of each material. The indented specimens were heated to desired temperatures for 20 min in a drop-bottom furnace and then quenched into water at room temperature. Crack extension after quenching was finally assessed through optical microscopy and SEM. 3 Results and discussion 3.1 Phase composition and microstructure Fig. 1 shows the X-ray diffraction (XRD) pattern of the monolithic ZrO 2 and 3Y-TZP/LaPO 4 composites after sintering at 1450 °C. All peaks can be identified as either ZrO 2 or monazite LaPO 4 . The content of m-ZrO 2 increased with increasing LaPO 4 content, and the content of m-ZrO 2 of Z15L C was higher than that of Z15L F ( Table 1 ). It was indicated that more spontaneous martensitic transformation occurred with the increased content of LaPO 4 in the 3Y-TZP/LaPO 4 composites during cooling from the sintering temperature. Moreover, the large grain size of LaPO 4 promoted the phase transformation. In the present experiment, the densities of ZrO 2 and LaPO 4 are 6.10 g/cm 3 and 5.08 g/cm 3 , respectively. The measured densities of sintered samples are listed in Table 2 . The relative density of Z15L F was higher than that of Z15L C , indicating that fine crystalline LaPO 4 promoted the densification process. Fig. 2 shows SEM micrographs of fractured surface of sintered specimens. The monolithic 3Y-TZP was of homogeneous structure and fine grain, and the fracture mode of it was mainly transgranular ( Fig. 2 (a)). Some fractured large sheet grain could be observed on the fracture surface of 3Y-TZP/LaPO 4 composites, indicating a mixed intergranular and transgranular cracking mode. In addition, owing to the addition of coarse LaPO 4 particle, there were more large grains in Z15L C ( Fig. 2 (b)) than in Z15L F ( Fig. 2 (c)). It was observed that Z30L F ( Fig. 2 (d)) contains coarser inclusions than that for Z15L C ( Fig. 2 (b)). The reason was that the increased content of LaPO 4 resulted in the coarsening of fine LaPO 4 . 3.2 Thermal–mechanical properties The thermal–mechanical properties of the materials are also presented in Table 2 . A general tendency was that the hardness, flexural strength and Vickers toughness of 3Y-TZP/LaPO 4 composites decreases with increasing LaPO 4 content. The decrease of Vickers hardness was directly due to the addition of soft LaPO 4 (Young's modulus of LaPO 4 is ∼100 GPa). Because of the weak-bonding interfaces between LaPO 4 and ZrO 2 , when samples were fractured, less energy was required with the increased content of LaPO 4 , thus resulting in the decrease of flexural strength. With the same content of LaPO 4 , the composite containing fine grained LaPO 4 has more weak interfaces than that containing coarse grained LaPO 4 . So, the flexural strength of Z15L F was lower than that of Z15L C . However, the more flaws generated at weak interfaces in Z15L F would improve the efficiency of microcrack toughening, thus resulting in a higher Vickers toughness. The Young's modulus and thermal expansion coefficient of 3Y-TZP/LaPO 4 composites were calculated by Eqs. (3) and (4) , respectively [21] : (3) E = E 1 V 1 + E 2 V 2 (4) α = α 1 E 1 V 1 + α 2 E 2 V 2 E 1 V 1 + E 2 V 2 where subscripts 1 and 2 denote ZrO 2 and LaPO 4 , respectively. V is the volume fraction. 3.3 Thermal shock The indentation thermal shock technique developed by Andersson and Rowcliffe [22] was used to investigate the thermal shock resistance of the 3Y-TZP/LaPO 4 composites. In this technique, two parameters, namely percentage of cracks propagated, P , and crack extension, S , were defined as follows: (5) P = Δ N N × 100 % where N (=48) is the total number of available radial cracks around the indentation and ΔN the number of radial cracks propagating after thermal shock loading. (6) S = Δ c c × 100 % where c is the average indentation crack length before thermal shock loading and Δ c the average crack length extended after thermal shock loading; only cracks which extended are considered in calculating S . Fig. 3 summarizes crack-growth behavior in the 3Y-TZP/LaPO 4 composites and pure ZrO 2 after single quench into a bath of water at room temperature. It is shown that P and S are dependent on Δ T and, the higher Δ T, the higher P and S . In all cases, the Z15L F shows the best crack-growth resistance after thermal shock, in that P and S are lower than for any of the other materials. The thermal shock resistance of Z15L C is only next to that of Z15L F , whereas Z30L F shows the poorest thermal shock resistance, which indicated that large grain size or higher content of LaPO 4 deteriorate the thermal shock resistance of 3Y-TZP/LaPO 4 composites. The partly cracks run through the surfaces for all the materials at temperature difference 250 °C. Fig. 4 shows thermal shock induced crack propagation SEM micrographs of Z15L F . Due to the addition of soft LaPO 4 , the grain pull-out was found on the polished surfaces of Z15L F , resulting in porosity over than that measured by Archimedes’ method. It was observed that thermal shock induced crack propagated along the weak interfaces between LaPO 4 and ZrO 2 , resulting in the crack deflection and bridging. The crack deflection and bridging would lead to a partial relief of the thermo-elastic strain energy and hence, contributed to resistance to crack propagation. In order to further investigate the hindering effect of LaPO 4 and the weak interfaces on the crack propagation through comparing the crack propagation behavior of 3Y-TZP and 3Y-TZP/LaPO 4 composites during thermal shock, several indentations close to each other were made on the polished surface of the samples. Fig. 5 shows the indentation cracks propagation SEM micrographs of 3Y-TZP and Z15L F . The crack propagation routes of Z15L F were more winding than those of pure ZrO 2 no matter what were before or after thermal shock. The cracks on the surface of pure ZrO 2 propagated in the original direction. But one of the cracks on Z15L F was branched and the propagation direction for the other one was changed. It was indicated that the Z15L F has better crack propagation resistance than pure ZrO 2 during thermal shock. Two different ways to evaluate the results from the indentation-quench test have been suggested: (1) use the lowest temperature difference where 25% of the cracks have grown more than 10% of their original length (Δ T 10 ) [23] , and (2) use the temperature difference where some of the cracks grow unstably out to the sample edge or stop at another indent (Δ T U ). A high Δ T 10 and Δ T U value indicates a high thermal shock resistance. The ranking of the materials, according to Δ T 10 , is as follows: Z15L F > Z15L C > 3Y-TZP > Z30L F . An expression for the prediction of Δ T U had been proposed previously [23] : (7) Δ T U = A [ K I C ( c U ) ] ( 1 − ν ) E α 1 f ′ β 1 a U where (8) A = 3 4 F π (9) β = h r k (10) f ′ β = 1 a β + b − c e − d / β Here, K IC is the fracture toughness, c U and a U are the respective crack length and crack depth at the onset of unstable crack growth, ν is the Poisson's ratio, E is the elastic modulus, α is the thermal expansion coefficient, h is the surface heat-transfer coefficient, r is the half-thickness of the sample, k is the thermal conductivity, and F is a geometric function. The parameters a , b , c , and d are constants and have values of 3.15, 1.33, 0.266, and 51.4, respectively, for an infinite plate [23] . It can be noticed that K I C ( c U ), E and α influence Δ T U directly, while h , r , and k influence via a function. For severe transient heat transfer (water quench, β ≫ 1), Δ T U is mainly determined by K I C ( c U ), E and α . So, a high K I C ( c U )/ Eα value indicates a high Δ T U . In earlier work, several thermal shock parameters (R parameters) had been defined by Hasselman. One of the parameters often used is R st . A high R st value indicates a high thermal shock resistance. R st is defined as (11) R s t = γ f E α 2 1 / 2 Since the fracture surface energy (12) γ f = K I C 2 2 E Eq. (11) is rewritten as (13) R st = K I C 2 E α Similar to Eq. (7) , Eq. (13) also indicates that the thermal shock resistance of 3Y-TZP/LaPO 4 composites can be determined by K IC ( c U ), E and α . The calculated R st values of the materials are listed in Table 2 . According to R st or Δ T U , the ranking of the thermal shock resistance of the materials, is as follows: Z15L F > Z15L C > 3Y-TZP > Z30L F , which is consisting with experiment results. 4 Conclusions Indentation techniques have been successfully used to study the thermal shock behavior of 3Y-TZP/LaPO 4 composites with different content and particle size of LaPO 4 addition. The composite containing 15 vol.% calcined (900 °C) LaPO 4 exhibited the best resistance to crack propagation. The crack deflection and bridging occurred at weak interfaces between ZrO 2 and LaPO 4 contributed to resistance to crack propagation. Larger grain size or higher content of LaPO 4 would deteriorate the thermal shock resistance of 3Y-TZP/LaPO 4 composites. The ranking of the thermal shock resistance of the materials according to calculated Δ T U or thermal shock resistance parameter R st was in good agreement with experimental results. Acknowledgements This research was supported by the National High Technology Research and Development Program of China (863 program) under Grant No. 2006AA03Z540, and the National Natural Science Foundation of China under Grant No. 50772073. References [1] D.P.H. Hasselman J. Am. Ceram. Soc. 46 11 1963 535 540 [2] D.P.H. Hasselman J. Am. Ceram. Soc. 52 1969 600 604 [3] Z.Y. Deng J.M.F. Ferreira Y. Tanaka Y. Isoda Acta Mater. 2007 3663 3669 [4] D.J. Fray Solid State Ionics 86–88 1996 1045 1054 [5] C.M.S. Rodrigues J.A. Labrincha F.M.B. Marques J. Eur. Ceram. Soc. 18 1998 2377 2381 [6] L.D. Schwartz C.M. Lukaniuk T.H. Etsell Adv. Eng. Mater. 1 1999 111 113 [7] O. Sbaizero G. Pezzotti Mater. Sci. Eng. A343 2003 273 281 [8] M. Aldridge J.A. Yeomans J. Eur. Ceram. Soc. 19 1998 1769 1775 [9] L. Wang J.L. Shi M.T. Lin H.R. Chen D.S. Yan Mater. Res. Bull. 36 2001 925 932 [10] J. Li Y.S. Yin X.Y. Tan J.D. Zhang J. Am. Ceram. Soc. 88 1 2005 235 238 [11] L. Wang J.L. Shi M.T. Lin H.R. Chen D.S. Yan J. Eur. Ceram. Soc. 21 2001 1213 1217 [12] Z.H. Yang D.C. Jia Y. Zhou Q.C. Meng P.Y. Shi C.B. Song Mater. Chem. Phys. 107 2008 476 479 [13] X.H. Zhang R.B. Zhang G.Q. Chen W.B. Han Mater. Sci. Eng. A 497 2008 195 199 [14] J.B. Davis D.B. Marshall R.M. Housley P.E.D. Morgan J. Am. Ceram. Soc. 81 8 1998 2169 2175 [15] P.E.D. Morgan D.B. Marshall J. Am. Ceram. Soc. 78 6 1995 1553 1563 [16] P.E.D. Morgan D.B. Marshall R.M. Housley Mater. Sci. Eng. A 195 1995 215 221 [17] Z.Q. Li J.C. Liu S. Li B. Zhou W. Jing Key. Eng. Mater. 368–372 P2 2008 1633 1635 [18] K. Niihara R. Morena D.P.H. Hasselman J. Mater. Sci. Lett. 1 1 1982 13 16 [19] H. Toraya M. Yoshimura S. Somiya J. Am. Ceram. Soc. 67 1984 119 121 [20] P. Pettersson M. Johnsson Z. Shen J. Euro. Ceram. Soc. 22 2002 1883 1889 [21] Z.H. Zhou P.D. Ding S.H. Tan J.S. Lan Mater. Sci. Eng. A 405 2005 272 276 [22] T. Andersson D.J. Rowcliffe J. Euro. Ceram. Soc. 8 1998 2065 2071 [23] M. Collin D. Rowcliffe Acta Mater. 48 2000 1655 1665",
        "keywords": [
            "3y-tzp",
            "indentation-quench",
            "lanthanum phosphate",
            "thermal shock resistance",
            "thermal shock",
            "crack propagation",
            "particle size",
            "grain size"
        ],
        "authors": [
            {
                "name": "Zhongqiu Li",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, No. 92 Weijin Road, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, No. 92 Weijin Road, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Shun Li",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, No. 92 Weijin Road, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Pengyu Zhang",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, No. 92 Weijin Road, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Materials Science & Engineering A",
        "year": 2009
    },
    "5neUY6m8": {
        "id": "5neUY6m8",
        "title": "Correction: Brønsted acid mediated covalent organic framework membranes for efficient molecular separation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hongjian Wang",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Long Chen",
                "org": "Tianjin Key Laboratory of Molecular Optoelectronic Science, School of Science, Tianjin University, Tianjin 300072, P. R. China"
            },
            {
                "name": "Hao Yang",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Meidi Wang",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Leixin Yang",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, P. R. China"
            },
            {
                "name": "Chenliang Cao",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Yanxiong Ren",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Yingzhen Wu",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Fusheng Pan",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Zhongyi Jiang",
                "org": "School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "",
        "year": 2019
    },
    "ImNNkY1q": {
        "id": "ImNNkY1q",
        "title": "Low-temperature fabrication of Al2O3-ZrO2 (Y2O3) nanocomposites through hot pressing of amorphous powders",
        "abstract": "Abstract   In this work, Al 2 O 3 -ZrO 2 (Y 2 O 3 ) nanocomposites were prepared by hot pressing of nanocrystalline and amorphous powders; effects of starting powders on densification and microstructure were investigated. To obtain nanocomposites with relative densities of higher than 98%, the minimum hot pressing temperature for nanocrystal powders was 1200 °C, and the resulting grain sizes were about 200 nm; for amorphous powders, however, the hot pressing temperature was as low as 1000 °C, and the products exhibited finer grains of about 90 nm. It was confirmed that, amorphous powders could be hot pressed into dense nanocomposites at lower temperatures than nanocrystalline powders, and the easier densification of amorphous powders was attributed to the higher free energy and finer particle size of amorphous particles. This work could provide new guidance for preparing bulk nanocomposites by hot pressing in both experiment and theory.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaojing Xu",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, PR China"
            },
            {
                "name": "Xiqing Xu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Wenhu Hong",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Feng Hou",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2016
    },
    "FIF1WaFV": {
        "id": "FIF1WaFV",
        "title": "Nanograined Al2O3-ZrO2 (Y2O3) ceramics through pressureless sintering of powders with different degrees of crystallinity",
        "abstract": "Abstract   In this work, Al 2 O 3 -ZrO 2  (Y 2 O 3 ) nanoceramics were prepared via pressureless sintering of powders with different degrees of crystallinity. It was demonstrated that, the crystallization of amorphous phase in starting powders highly enhanced the densification during sintering. When the crystal content was 25 vol%, the powders exhibited better sinterability than other powders, and they could be sintered into bulk nanoceramics with relative densities higher than 98% at 1400 °C and 1500 °C. The superior sinterability of C25 powders was due to the crystallization of amorphous phase promoted by the as-existed nanocrystalline powders as nucleation seeds. The obtained nanoceramic exhibited homogenously distributed ZrO 2  and Al 2 O 3  particles with grain size of about 450 nm, and displayed excellent mechanical property with Vickers hardness of 15.3 GPa, fracture toughness of 5.2 MPa m 1/2 , and flexure strength of 1190 MPa. This work may provide new guidance for optimization in preparing bulk nanoceramics by managing the crystallinity of starting powders.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiqing Xu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Mengmeng Zhuang",
                "org": "China Automotive Technology and Research Center, 68 East Xianfeng Road, Dongli District, Tianjin 300300, People's Republic of China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            },
            {
                "name": "Feng Hou",
                "org": "Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, People's Republic of China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2017
    },
    "AfGuuwcJ": {
        "id": "AfGuuwcJ",
        "title": "A heat-resistant preceramic polymer with broad working temperature range for silicon carbide joining",
        "abstract": "Abstract   A room temperature curable heat-resistant adhesive with broad working temperature range was prepared through organic and inorganic modification. The preceramic polymethylsiloxane showed low bonding strength for silicon carbide from 400 °C to 600 °C because of the decomposition of polymer network. So the modification with epoxy resin was used to generate strong blending and copolymerization network which decomposed at higher temperature over 500 °C. The ceramization of active fillers and preceramic polymer compensated the bonding strength with rising temperature, thus eliminating the weak stage from 400 °C to 600 °C. The modification with fillers greatly improved its bonding strength at high temperature over 1000 °C. Consequently, the modified adhesive exhibited outstanding bonding strength tested at room temperature between 9.29 ± 0.56 MPa and 37.28 ± 1.33 MPa after heat-treatment from 25 °C to 1500 °C and the bonding strength directly tested at the temperature from 25 °C to 800 °C over 8.21 ± 0.40 MPa. The adhesive shows the potential to extend the application for engineering ceramic joining.",
        "keywords": "",
        "authors": [
            {
                "name": "Bo Tang",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300350, PR China"
            },
            {
                "name": "Mingchao Wang",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300350, PR China"
            },
            {
                "name": "Ruiming Liu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300350, PR China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300350, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300350, PR China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin, 300350, PR China"
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2018
    },
    "ti0rF13f": {
        "id": "ti0rF13f",
        "title": "Fabrication and compressive properties of closed-cell alumina ceramics by binding hollow alumina spheres with high-temperature binder",
        "abstract": "Abstract   Here a facile method to fabricate closed-cell alumina ceramics by binding hollow alumina spheres with high-temperature binder was introduced. Hollow alumina spheres as the pore-forming agent were bonded together by silica and phosphate binder to form closed-cell structure at the high temperatures. The mechanical properties of as-received closed-cell alumina ceramic can be tailored by the volume fraction of hollow alumina spheres and sintering schedule. Besides, the effects of fusing agent B 2 O 3  and chopped mullite fiber on bulk density and compressive strength of closed-cell alumina ceramics were investigated, respectively. The results indicated that the addition of chopped mullite fiber can effectively enhance the compressive strength of the closed-cell alumina ceramic without significant change in bulk density. The compressive strength of the closed-cell alumina ceramics with 62.5% total porosity was 11.97 MPa when 5 wt% B 2 O 3  and 6 wt% chopped mullite fibers were added in the sample.",
        "keywords": "",
        "authors": [
            {
                "name": "Haitao Geng",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Jiayu Zhou",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Xiqing Xu",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Mingchao Wang",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin, 300072 China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2016
    },
    "wcNhJ8Nv": {
        "id": "wcNhJ8Nv",
        "title": "Synthesis of Anatase TiO_2 Nanoparticles by Improved Sol-Gel Process at Low Temperature",
        "abstract": "The nanocrystalline TiO_2 powder were prepared by improved sol-gel method at low temperature under ambient pressure. The prepared TiO_2 powder was characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM). It is found that the yield of anatase TiO_2 significantly increases with the reduction of pH by increasing the nucleation rate of anatase. There is an optimum amount of water in sol for the formation of anatase by combining two effects on the concentration of Ti(OH)_4 in gels. Increasing in reaction temperature also benefit to the nucleation of anatase of TiO_2.",
        "keywords": [
            "nanocrystalline",
            "titanium dioxide",
            "low temperature",
            "improved sol-gel process"
        ],
        "authors": [
            {
                "name": "Wang YuLing",
                "org": "Department of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Du HaiYan",
                "org": "Department of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Han Jing",
                "org": "Department of Materials Science & Engineering, Tianjin University, Tianjin , China"
            },
            {
                "name": "Cui Lan",
                "org": "Department of Materials Science & Engineering, Tianjin University, Tianjin , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2005
    },
    "02LQhWQZ": {
        "id": "02LQhWQZ",
        "title": "Single-phase and well-dispersed Cu1.75S nanocrystals by ambient pressure diethylene glycol solution synthesis",
        "abstract": "Single-phase, well-dispersed Cu1.75S nanocrystals were synthesized by an ambient pressure, hydrazine hydrate and ethylenediamine co-assisted diethylene glycol based solution chemical process using copper chloride and thioacetamide as precursors at the temperature range from 180 to 210 °C. Influence of hydrazine hydrate and ethylenediamine adding amounts, synthetic temperature on crystal growth, size distribution and optical properties of the synthesized Cu1.75S nanocrystals were investigated by XRD, TEM, HRTEM, EDX and UV-vis measurements. The synthetic reaction at above 200 °C grew flaky-shaped nanocrystals with relatively narrow size distribution. The formation of single-phase Cu1.75S nanocrystals in the diethylene glycol based solution process might be involved in the presence of intermediate [Cu(en)n]1+ and [Cu(NH3) 4]2+ complexes in reaction solution, providing a stable Cu(I) and Cu(II) valent-mixed precursor. © 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Crystal growth",
            "Cu1.75S nanocrystals",
            "Diethylene glycol solvent",
            "Solution synthesis"
        ],
        "authors": [
            {
                "name": "Xuerong Zheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Hui Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yueqiu Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Xin Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2013
    },
    "0g1zUZXo": {
        "id": "0g1zUZXo",
        "title": "Preparation of homogeneous mullite‐based fibrous ceramics by starch consolidation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Wenjie Zang",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            },
            {
                "name": "Wenjie Zang",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            },
            {
                "name": "Tao Jia",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            },
            {
                "name": "Xue Dong",
                "org": "College of Aeronautical Engineering Civil Aviation University of China Tianjin China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            },
            {
                "name": "Feng Hou",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Material Science and Engineering Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education Tianjin University Tianjin China"
            }
        ],
        "venue": "Journal of the American Ceramic Society",
        "year": 2018
    },
    "3pJReIAw": {
        "id": "3pJReIAw",
        "title": "Hierarchical mullite structures and their heat-insulation and compression-resilience properties",
        "abstract": "Near-net-shaped hierarchical structure-adjustable short mullite fibers/mullite whiskers frameworks (MF/MW frameworks) were prepared by slurry-filtration and heat-treating method. The main structure of MF/MW framework was constituted by lap-jointed mullite fibers. Every single fiber in the framework was densely covered by mullite whiskers which formed through fluorine-catalyzed gas-phase reaction, and the fibers actually served as curved substrates for the mullite whiskers' growth. The lap-jointing points of the fibers were served by movable intersected mullite whiskers. Moreover, the microstructure of the frameworks could be adjusted by tailoring the raw materials mass ratio. The volume densities, the apparent porosities and the thermal conductivities of the MF/MW frameworks in different raw materials mass ratios were 0.459-0.487 g/cm3, 79.7-82.8% and 0.1356-0.1965 W/k m, respectively. The compression-resilience property of the samples was tested under 0.4 MPa at room temperature. The compression ratio and resilience ratio of the MF/MW frameworks in different raw materials mass ratios were 1.63-2.25% and 92.67-98.16%, respectively. The MF/MW frameworks with advanced thermal and mechanical properties were considered to be promising high-temperature heat-insulation material. ? 2013 Elsevier Ltd and Techna Group S.r.l.",
        "keywords": [
            "compression- resilience",
            "heat-insulation",
            "mullite whiskers",
            "short mullite fibers",
            "heat insulation"
        ],
        "authors": [
            {
                "name": "Shan Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Feng Hou",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Sue Ren",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haitao Geng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2014
    },
    "kwl1Rokt": {
        "id": "kwl1Rokt",
        "title": "Hierarchical structural silica-fiber-woven/mullite-whisker material prepared by surface etching and gas-phase reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shan liu",
                "org": "tianjin university"
            },
            {
                "name": "jiachen liu",
                "org": "tianjin university"
            },
            {
                "name": "haiyan du",
                "org": "tianjin university"
            },
            {
                "name": "feng hou",
                "org": "tianjin university"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "3uREtGBZ": {
        "id": "3uREtGBZ",
        "title": "Well-dispersed, plate-shaped Cu2-xSe nanocrystals by ambient-pressure trithylene glycol-based solution synthesis",
        "abstract": "Single-phase, well-dispersed, plate-shaped cubic Cu2-xSe nanocrystals were synthesized through an ambientpressure solution chemical process using green triethylene glycol (TEG) as solvent, copper(II) chloride and selenium powder as precursors, hydrazine hydrate as reducing agent and polyvinylpyrrolidone as dispersing agent. The basic structural characteristics of the as-synthesized Cu2-xSe nanoplates are described. The influence of temperature, reaction time and the amount of added polyvinylpyrrolidone on the synthesis product were investigated by X-ray diffraction, high-resolution transmission electron microscopy, energy dispersive X-ray spectroscopy and UV-vis-NIR measurments. The results showed that the resulting cubic Cu2-xSe phase was thermodynamically stable when the initial Cu:Se atomic ratio in the reaction solution was 2:1. The high injection temperature was suitable for the formation of single-phase Cu2-xSe nanoplates with relatively uniform sizes. The strong capping effect of polyvinylpyrrolidone with multi-acyl side group molecule structure effectively controlled the morphological evolution and dispersibility features of the plate-shaped nanocrystals in our TEG-based solution synthesis. © 2013 by American Scientific Publishers.",
        "keywords": [
            "Ambient pressure",
            "Cu2-xSe nanocrystals",
            "Plate-shaped",
            "TEG solution synthesis"
        ],
        "authors": [
            {
                "name": "Xin Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Zhengguo Jin",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Hui Liu",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Yueqiu Wang",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Xuerong Zheng",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            },
            {
                "name": "Lan Cui",
                "org": "Tianjin University(Tianjin University,Tianjin Univ.),Tianjin,China"
            }
        ],
        "venue": "Science of Advanced Materials",
        "year": 2013
    },
    "buJFoWex": {
        "id": "buJFoWex",
        "title": "The prediction of elastic modulus of the mullite fiber network based on the actual structure architecture",
        "abstract": "Abstract   Accurately establishing the relationship between the network architecture characteristics and performance of fibrous porous ceramics is instructive for structural design and performance control. In the present work, fibrous, high porous (82.87–90.02%), low density (0.247–0.512 g/cm 3 ) and low elastic modulus (50.62–188.56 MPa) mullite ceramics were fabricated by freeze casting. The three dimensional network architectures were characterized by X-ray tomography technique and quantitatively analyzed by 3D image analysis software (imorph,  www.imorph.fr ). The radius (5.04 µm), types, lengths (64.72–96.49 µm) and orientations (0.87–1.45, anisotropy parameter) of fiber segments in the network architecture were investigated. The extracted results were employed to predict the Youngu0027s modulus of the mullite fibrous porous ceramics according to a model based on the bending and axial compression of single fiber segment. The predicted Youngu0027s modulus agreed well with the experimental results. The differences of Youngu0027s modulus and Poisson ratio between the prediction and the model of Markaki and Clyne were compared. The comparison showed that the difference became larger when the aspect ratio of the fiber segment was less than 6 due to the effect of axial compression. The predicted Poisson ratio had a certain dependence on fiber segment aspect ratio and got close to the constant (1/π) reported by Markaki and Clyne with the increase of fiber segment aspect ratio.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoxia Hu",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xiaohui Ma",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xue Dong",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Chunjie Cao",
                "org": "Carle (Shanghai) Management Co., Ltd., Beijing Demonstration Center, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Zhong Chen",
                "org": "School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore"
            }
        ],
        "venue": "Ceramics International",
        "year": 2017
    },
    "uB7eHcAQ": {
        "id": "uB7eHcAQ",
        "title": "Immobilized TiO_2 Films on PP by Impregnating Method",
        "abstract": "TiO2 films are immobilized on PP by impregnating method. The effects of surface modification methods and properties of TiO2 slurry (such as solid content and suspension stability)on the film formation and structure are investgated. The surface morphologies of TiO2 films are observed by scanning electron microscope. The surface atom groups and chemical state are analyzed by FRIR and XPS, Experimental results indicate that ion sputtering plating Ti on PP surface and sulfonated treat PP surface can improve the adhesion between PP and TiO2 powder. TiO2 films immobilized on PP surface which plating Ti are more even and compact. Sulfonated treatment should be in a optimized time,the PP surface is intensely erode when the time is too long. The surface sulfonated ratios (S/C)are as a function of sulfonated time. The high solid content and viscosity of TiO2 slurry are not good for preparing uniform,no cracking and good adhesion films. Uniform films can be obtained from low concentration slurries.",
        "keywords": [
            "titanium dioxide",
            "polypropylene plastic",
            "impregnated process",
            "surface treatment"
        ],
        "authors": [
            {
                "name": "WANG Yuling",
                "org": "Department of Materials Science and Engineering,Tianjin University,Tianjin "
            },
            {
                "name": "DU Haiyan",
                "org": "Department of Materials Science and Engineering,Tianjin University,Tianjin "
            },
            {
                "name": "HAN Jing",
                "org": "Department of Materials Science and Engineering,Tianjin University,Tianjin "
            },
            {
                "name": "WANG Hui",
                "org": "Department of Materials Science and Engineering,Tianjin University,Tianjin "
            }
        ],
        "venue": "Materials Review",
        "year": 2006
    },
    "oXJ0DrrO": {
        "id": "oXJ0DrrO",
        "title": "Freeze casting of composite system with stable fiber network and movable particles",
        "abstract": "Abstract   Freeze casting was employed to fabricate alumina fiber-based porous ceramics. The binder particles were rejected by ice crystals from the gaps of the network to fibers and bonded them to obtain strong and light network. The effects of fiber character, cooling temperature and slurry viscosity on the structure formation were investigated. The structure and properties of the fibrous porous ceramics were determined by two factors: the fiber network and the dispersion of binders. The cooling temperature and slurry viscosity affected the dispersion of the particles rejected by the solidification front while the fiber length affected the fiber network. The material with optimal properties was obtained with 5 wt% PVA, 5 wt% silica sol and 1 vol% alumina fibers when freezing at −20 °C. The bulk density was 0.199 g/cm 3  and the specific strength was 3.860 N m/kg.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoxia Hu",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Department of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Lina Yang",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Department of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Lingyu Li",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Department of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Dieni Xie",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Department of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Department of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2016
    },
    "Vr3b5NLg": {
        "id": "Vr3b5NLg",
        "title": "Effects of Carbon Material Structures on the Nanodiamond Synthesis by Laser Irradiation",
        "abstract": "Diamond crystals in nanometric range have been synthesized in graphite suspension by pulsed laser irradiation,and the effects of three kinds of carbon material( carbon black,crystalline flake graphite and mi- crocrystalline graphite)on the formation of diamond are analyzed.The structures of the carbon materials are characterized by Raman spectra which show that the crystallization degree increases from carbon black,micro- crystalline graphite to crystalline flake graphite in turn.The structures of the products after Nd:YAG laser irra- diation are characterized by transmission electron microscopy(TEM).The experiment results show that only mi- crocrystalline graphite by laser transformed into diamond( cubic diamond about 5 nm)in the three carbon mate- rials.It also demonstrates that microcrystalline graphite is more advantageous in the synthesis of nanodiamond than carbon black and crystalline flake graphite when the laser power density is 10~6 W/cm~2.",
        "keywords": [
            "graphite",
            "pulsed laser",
            "diamond",
            "nanocrystal"
        ],
        "authors": [
            {
                "name": "SUN Jing",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            },
            {
                "name": "ZHAI Qi",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            },
            {
                "name": "JIANG Lei",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            },
            {
                "name": "LEI Yi-wen",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            },
            {
                "name": "YANG Xing",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            },
            {
                "name": "DU Xi-wen",
                "org": "School of Materials Science and Engineering,Tianjin University,Tianjin ,China"
            }
        ],
        "venue": "Nanotechnology and Precision Engineering",
        "year": 2006
    },
    "O0ckVe0L": {
        "id": "O0ckVe0L",
        "title": "Preparation of dense amorphous Al 2 O 3 –ZrO 2 –Y 2 O 3 by two-step hot pressing",
        "abstract": "",
        "keywords": [
            "densification",
            "crystallization"
        ],
        "authors": [
            {
                "name": "xiqing xu",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "yi wang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "mingchao wang",
                "org": ""
            }
        ],
        "venue": "Journal of The European Ceramic Society",
        "year": 2015
    },
    "mNpOp5mv": {
        "id": "mNpOp5mv",
        "title": "Effects of interlayer composition on joining of 25%CePO4/ZrO2–ZrO2 ceramics on green state",
        "abstract": "Green bodies of 25%CePO 4 /ZrO 2 and ZrO 2 ceramics were joined without applied pressure by using mixed powders slurries composed of CePO 4 and ZrO 2 . The effects of CePO 4 /(CePO 4 +ZrO 2 ) ratio of the interlayer on the bond strength and microstructure of the joints were investigated. Maximum bond strength of 414 MPa was obtained by joining with an adhesive with the ratio of 0.5. Under the experimental conditions, the grain size of the particles grown in the joint was smaller than those in joined ceramics. The microstructure of the joint was more homogeneous than that of the matrix.",
        "keywords": [
            "A. Joining",
            "Slurries",
            "B. Interface",
            "Green body"
        ],
        "authors": [
            {
                "name": "Hai Gao",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": ""
            },
            {
                "name": "Mingzheng Liu",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Lijuan Wang",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Weirong Huo",
                "org": "Key Lab for Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science & Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2004
    },
    "ULOV4cWS": {
        "id": "ULOV4cWS",
        "title": "High-temperature bonding performance of modified heat-resistant adhesive for ceramic connection",
        "abstract": "",
        "keywords": [
            "ceramics",
            "heat treatment",
            "adhesives"
        ],
        "authors": [
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "xin tao",
                "org": ""
            },
            {
                "name": "xiqing xu",
                "org": ""
            },
            {
                "name": "ran miao",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2015
    },
    "n8pMsyso": {
        "id": "n8pMsyso",
        "title": "Microstructure, mechanical properties and thermal shock resistance of ZrO2–LaPO4 composites",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "shun li",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "zhongqiu li",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "iPw2i6bU": {
        "id": "iPw2i6bU",
        "title": "Microstructure, mechanical properties and thermal shock resistance of ZrO 2 –LaPO 4 composites",
        "abstract": "",
        "keywords": [
            "thermal shock",
            "microstructure",
            "scanning electron microscopy",
            "thermal shock resistance",
            "fracture toughness",
            "ceramics",
            "flexural strength",
            "microstructures",
            "composites"
        ],
        "authors": [
            {
                "name": "zhongqiu li",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "shun li",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "RI3tVYc2": {
        "id": "RI3tVYc2",
        "title": "Effect of mullite fiber content on the microstructure and properties of porous mullite fiber/silica composite",
        "abstract": "Abstract   Porous mullite fiber/silica composite was successfully fabricated by a TBA-based gel-casting, and the influence of mullite fiber content on the composite microstructure and properties were investigated. The results show that the mullite fiber content played an important role in tailoring the microstructure of the composite, consequently influencing the sample properties. The composite fabricated with high fiber content showed a porous fibrous structure with mullite fibers as the fiber skeleton and silica as the binder, and exhibited a low density, high porosity, excellent elasticity and low thermal conductivity. On the contrary, the sample fabricated with low fiber content possessed a high density and high strength due to its dense microstructure which is similar with that of the fiber reinforced ceramic matrix composite.",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Zhang",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xue Dong",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Feng Hou",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "School of Materials Science and Engineering, Key Lab of Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2016
    },
    "QNf6xAi8": {
        "id": "QNf6xAi8",
        "title": "Microstructure, mechanical properties and thermal shock resistance of ZrO 2LaPO 4 composites",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhongqiu Li",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": ""
            },
            {
                "name": "Shun Xing Li",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "XFG6nGId": {
        "id": "XFG6nGId",
        "title": "Preparation and characteristics of CuInSe2 thin films by dip-coating method using its nanocrystal ink",
        "abstract": "CdS nanocrystals were synthesized by hot injection method using EG as solvent, polyvinylpyrrolidone as dispersant, triethanolamine as stabilizing agent, Cd(NO 3 ) 2 ·4H 2 O and H 2 NCSNH 2 as cadmium and sulfur sources respectively. The synthesized nanocrystals were washed and ultrasonically dispersed with absolute ethanol to prepare nanocrystal ink. CdS thin films were deposited by dip-coating glass substrates with the nanocrystal ink and annealed at 450 °C in Ar atmosphere. Crystalline phase, morphology and element stoichiometry of the CdS nanocrystals derived from different synthesis temperatures were investigated by XRD, TEM and EDS. Surface morphology, crystalline phase and optical absorption spectrum of the CdS films were characterized by SEM, XRD and UV–Vis.",
        "keywords": [
            "CdS",
            "Dip-coating",
            "Hot injection synthesis",
            "Nanoparticles",
            "Thin films"
        ],
        "authors": [
            {
                "name": "Weidong Wang",
                "org": "School of Materials Science and Engineering, Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Zhengguo Jin",
                "org": ""
            },
            {
                "name": "Hui Liu",
                "org": "School of Materials Science and Engineering, Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education, Tianjin University, Tianjin 300072, PR China"
            },
            {
                "name": "Haiyan Du",
                "org": "Analysis and Measurement Center, Tianjin University, Tianjin 300072, PR China"
            }
        ],
        "venue": "Materials Letters",
        "year": 2011
    },
    "y20nihAY": {
        "id": "y20nihAY",
        "title": "Mechanical properties and high-temperature resistance of the hollow glass microspheres/borosilicate glass composite with different particle size",
        "abstract": "Abstract   Buoyancy material with high temperature resistance was successfully prepared through a tert-butyl alcohol gelcasting process. Borosilicate glass (BG) and hollow glass microspheres (HGMs) with different average diameters were used as the matrix and the filler, respectively. Results show that the compressive strength increased with the decrease of the mean diameter of HGMs, and the sample consisting of the filler of HGMs with a small average diameter exhibited high compressive strength of 25.04 MPa. Youngu0027s modulus values of the composite sintered at 700 °C and 750 °C were distributed over in the range of the values predicted from Ashby-Gibson model to Hashin-Shtrikman model and other moduli values agreed well with that of Past model prediction. Weibull moduli ( m ) reflecting the variation degree of the sample compressive strength were in the range of 5–15. The compressive strength of the composites composed of the HGMs with small average particle size tested at 500 °C was as high as 7.94 MPa.",
        "keywords": "",
        "authors": [
            {
                "name": "Sue Ren",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xiutao Li",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, China"
            },
            {
                "name": "Xiuju Zhang",
                "org": "Research & Development Center of China Academy of Launch Vehicle Technology, Beijing 100076, China"
            },
            {
                "name": "Xiqing Xu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Xue Dong",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            },
            {
                "name": "Anran Guo",
                "org": "Key Laboratory of Advanced Ceramics and Mechanical Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2017
    },
    "I7oxo4oU": {
        "id": "I7oxo4oU",
        "title": "A SiC whisker reinforced high-temperature resistant phosphate adhesive for bonding carbon/carbon composites",
        "abstract": "",
        "keywords": [
            "heat treatment",
            "adhesive"
        ],
        "authors": [
            {
                "name": "mingchao wang",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "anran guo",
                "org": ""
            },
            {
                "name": "xin tao",
                "org": ""
            },
            {
                "name": "xue dong",
                "org": ""
            },
            {
                "name": "haitao geng",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2015
    },
    "zXkUzXf7": {
        "id": "zXkUzXf7",
        "title": "Effects of interlayer composition on joining of 25%CePO 4 /ZrO 2 –ZrO 2 ceramics on green state",
        "abstract": "",
        "keywords": [
            "slurries",
            "bond strength",
            "grain size",
            "microstructures"
        ],
        "authors": [
            {
                "name": "hai gao",
                "org": ""
            },
            {
                "name": "jiachen liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "mingzheng liu",
                "org": ""
            },
            {
                "name": "lijuan wang",
                "org": ""
            },
            {
                "name": "weirong huo",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2004
    },
    "towsPtYM": {
        "id": "towsPtYM",
        "title": "The formation mechanism of mullite whisker in the mullite fiber network",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Dieni Xie",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Lina Yang",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Lingyu Li",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Wenjie Wang",
                "org": ""
            },
            {
                "name": "Jiachen Liu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Haiyan Du",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            },
            {
                "name": "Xiaoxia Hu",
                "org": "Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University"
            }
        ],
        "venue": "Journal of The Ceramic Society of Japan",
        "year": 2018
    },
    "diJwnbAg": {
        "id": "diJwnbAg",
        "title": "Determination of Gold in Ore by Extraction With Secondary Octyl Alcohol-Coloring With TMK-n-butyl-alcohol",
        "abstract": "Determination of gold in ore has been studied.The ore sample is dissolved with aqua.Gold in solution is solvent extracted with secondary octyl alcohol and spectrophotometric determined by coloring with TMK-n-butyl-alcohol in media of acetic acid-sodium acetate at pH=4.The Beer's Law is obeyed in the range of 0～5 μg/5mL for gold.The result is satisfactory.",
        "keywords": [
            "spectrophotometry",
            "determination",
            "solvent extraction",
            "ore",
            "gold"
        ],
        "authors": [
            {
                "name": "WU Wei-ming",
                "org": "Jiangxi University of Science And Technology,Ganzhou,Jiangxi,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Jiangxi University of Science And Technology,Ganzhou,Jiangxi,China"
            },
            {
                "name": "YANG Ping",
                "org": "Jiangxi University of Science And Technology,Ganzhou,Jiangxi,China"
            },
            {
                "name": "WANG Guo-chang",
                "org": "Jiangxi University of Science And Technology,Ganzhou,Jiangxi,China"
            }
        ],
        "venue": "Hydrometallurgy of China",
        "year": 2006
    },
    "uhZcX2Kj": {
        "id": "uhZcX2Kj",
        "title": "Application of Amino Acid in Metal Corrosion Suppression",
        "abstract": "The traditional inhibitor may not biodegradate,thus causes the environment questions.Amino acid inhibitor is environment friendly green inhibitor which has wide application prospect at present.Amino acid is the basic composing substance of protein.Because of the small molecule structure,the stability of amino acid is very good,it can utilize in acidity,neuter and atmosphere medium abroad.The inhibitive principle,inhibiting origin and the withdrawing method,the test method of inhibition,the application to eclipsing aspect as well as the development prospect are summarized.",
        "keywords": [
            "Metal corrosion",
            "Green inhibitor.",
            "Amino acid"
        ],
        "authors": [
            {
                "name": "WU Wei-ming",
                "org": " School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China;School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China"
            },
            {
                "name": "YANG Ping",
                "org": " School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": " School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China;School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China"
            },
            {
                "name": "LU Min-xu",
                "org": "School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China"
            },
            {
                "name": "ZHONG Hong-ming",
                "org": " School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China"
            }
        ],
        "venue": "Surface Technology",
        "year": 2006
    },
    "N4YxxDPn": {
        "id": "N4YxxDPn",
        "title": "Influence of Surface Treatment on the Anticorrosion Performance of Organic Coating/Metal",
        "abstract": "The anticorrosion behavior of untreated,silane treated and phosphating treated metal surface on metal is studied,and the epoxy resin is used as coating.The epoxy coated metal,which is the working electrode,is immerged in the 3.5% NaCl solution.The AC (alternating current) impedance is tested.The results show that the anticorrosion behavior of silane treated sample is better than that of the untreated and phosphating treated.The silane film can protect the metal substrate very well.",
        "keywords": [
            "surface treatment organic coating anticorrosion performance electrochemical impedance spectra"
        ],
        "authors": [
            {
                "name": "ZHANG Ying-huai",
                "org": "Corrosion and Protection Center,School of Materials Science and Engineering,University of Science & Technology1 Beijing,, P. R. China"
            },
            {
                "name": "XU Li-ning",
                "org": "Corrosion and Protection Center,School of Materials Science and Engineering,University of Science & Technology1 Beijing,, P. R. China"
            },
            {
                "name": "LU Min-xu",
                "org": "Corrosion and Protection Center,School of Materials Science and Engineering,University of Science & Technology1 Beijing,, P. R. China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Corrosion and Protection Center,School of Materials Science and Engineering,University of Science & Technology1 Beijing,, P. R. China;Jiangxi University of Science and Technology,School of Materials and Chemical Engineering2,Ganzhou ,P.R.China"
            },
            {
                "name": "XU Xi-cheng",
                "org": "Corrosion and Protection Center,School of Materials Science and Engineering,University of Science & Technology1 Beijing,, P. R. China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2007
    },
    "7KJF4E4e": {
        "id": "7KJF4E4e",
        "title": "Inhibition of Amino Acids Against Steel in Hydrochloric Acid Solution",
        "abstract": "The inhibition effect of glutamic acid towards the corrosion of X65 steel in hydrochloric acid solution(10%) was investigated using polarization techniques、electrochemical impedance spectroscopy(EIS) and SEM.The corrosion rate,corrosion potential(Ecoor),polarization resistance(Rp) and inhibition efficiency(η) were determined.The results revealed that the inhibitor is a mixed type inhibitor.It has promising corrosion inhibition efficiency at low concentrations.The inhibition efficiency(η) increased with increasing the concentration.The maximum inhibition efficiency appeared at 0.3 g·L-1.",
        "keywords": [
            "EIS",
            "glutamic acid",
            "hydrochloric acid",
            "corrosion inhibitor"
        ],
        "authors": [
            {
                "name": "CHENG Ming-yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "WU Wei-ming",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China;School of Materials Science and Engineering,University of Science andTechnology Beijing,Beijing ,China"
            },
            {
                "name": "LIU He-ming",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            }
        ],
        "venue": "Electrochemistry",
        "year": 2008
    },
    "DIX6lEgy": {
        "id": "DIX6lEgy",
        "title": "Progress on Green Inhibitors of amino acids",
        "abstract": "Green Chemistry applied to corrosion is direction of the corrosion inhibitors' science in the future.At present,amino acids inhibitors are widely studied as environmental friendly inhibitor.In this paper,experimental study methods,the sorts of amino acids,corrosion medium,inhibition mechanisms are summarized.",
        "keywords": [
            "development",
            "amino acid",
            "inhibitors",
            "environmental protection",
            "research"
        ],
        "authors": [
            {
                "name": "CHENG Mingyan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou Jiangxi ,China"
            },
            {
                "name": "WU Weiming",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou Jiangxi ,China;University of Science and Technology of Beijing,School of Materials Science and Engineering,Beijing ,China"
            },
            {
                "name": "DU Haiyan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou Jiangxi ,China;University of Science and Technology of Beijing,School of Materials Science and Engineering,Beijing ,China"
            }
        ],
        "venue": "Cleaning World",
        "year": 2007
    },
    "tCoQbmgt": {
        "id": "tCoQbmgt",
        "title": "Progress and future development of ester-surfactants derived from fatty acid alkanolamide",
        "abstract": "The research status in the field of synthesis,performance and application of fatty acid alkylolamide sulfate,fatty acid alkylolamide phosphate,fatty acid alkylolamide borate were summarized.The future development trend of this kind of surfactants were prospected.",
        "keywords": [
            "ester-surfactants derived from fatty acid alkanolamide",
            "development",
            "anionic surfactant"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China;School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China"
            },
            {
                "name": "LIU He-ming",
                "org": "School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China"
            }
        ],
        "venue": "China Surfactant Detergent & Cosmetics",
        "year": 2007
    },
    "MRxuW7XC": {
        "id": "MRxuW7XC",
        "title": "DEVELOPMENT AND EVALUATION OF CORROSION INHIBITOR EXTRACTED FROM OIL-TEA-CAKE",
        "abstract": "A kind of corrosion Inhibitor for acid pickling has been made from oil-tea-cake.The optimum parameters of the preparation technique were determined.The capability of corrosion inhibition for mild steel was investigated by polarization curves and corrosion potential measurements as well as electrochemical impedance spectroscopy.The total content of amino acid of inhibitor could reach 24.38 g·L-1 when the granularity of oil-tea-cake was 50-60 grit number,the ratio of volume of water to hydrochloric acid was 1:1 and the continuous time of hydrolysis was 1.5 h.Inhibition efficiencies of 81.2% could be obtained in 10%(V%)hydrochloric acid solution with 2%(V%) inhibitor.Polarization curves showed that it was a mixed type of inhibitor.",
        "keywords": [
            "Corrosion inhibitor",
            "Electrochemical impedance spectroscopy(EIS)",
            "Oil-tea-cake"
        ],
        "authors": [
            {
                "name": "WU Wei-ming",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China;University of Science and Technology of Beijing,School of Materials Science and Engineering,Beijing ,China"
            },
            {
                "name": "CHENG Ming-yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "LU Min-xu",
                "org": "University of Science and Technology of Beijing,School of Materials Science and Engineering,Beijing ,China"
            },
            {
                "name": "WANG Chun-mei",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            }
        ],
        "venue": "Corrosion & Protection",
        "year": 2007
    },
    "tThUCb7T": {
        "id": "tThUCb7T",
        "title": "STUDY OF INHIBITION MECHANISM OF STEARAMIDE DERIVATIVE ON CO_2 CORRODED STEEL X65",
        "abstract": "The mechanisms of the stearamide derivative inhibited CO2 corrosion on the mild steel X65 were studied in derivative containing aerated brine solution by electrochemical polarization measurements and electrochemical impedance spectroscopy (EIS) measurements. The electrochemical data showed that the corrosion resistance was greatly enhanced in the presence of stearamide derivative inhibitor. Polarization curves revealed that the inhibitor is an anodic type inhibitor, belonging to interface adsorbtion, and the inhibition is due to the negative catalytic mechanism. The maximum inhibition efficiency appeared at a concentration of inhibitor of 0.5 g/L. EIS has two time constants and the equivalent circuit was suggested as R(C(R(CR))).",
        "keywords": [
            "mild steel",
            "electrochemical impedance spetroscopy (EIS)",
            "electrochemical polarization",
            "carbon dioxide corrosion",
            "corrosion inhibitor"
        ],
        "authors": [
            {
                "name": "DU Haiyan",
                "org": ",WU School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing  School of Materials and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou "
            },
            {
                "name": "LU Minxu",
                "org": ",WU School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing  School of Materials and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou "
            },
            {
                "name": "WU Yinshun",
                "org": ",WU School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing  School of Materials and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou "
            }
        ],
        "venue": "Acta Metallurgica Sinica",
        "year": 2006
    },
    "UI5ShG5P": {
        "id": "UI5ShG5P",
        "title": "The Process Extraction Amino Acid from Bean Dregs and Its Corrosion Mechanism",
        "abstract": "We extract commixture amino acids from bean dregs in this experiment and determine those inhibition mechanism. Reaction time, distribution of particle size of bean dreg and hydrochloric acid concentration are the three mainly conditions on this experiment. The best extract condition is that 50～60 eyes, hydrochloric acid concentration are 20%,reaction time is 200 min. The concentration of liquid thickness gains is 2.688g/L. The corrosion inhibitor commixture amino acids to carbon dioxide corrosion was selected by means of PARSTAT2263,Tafel polarization curve and linear polarization corrosion rate measurement. The inhibition yield is about 66.69%.",
        "keywords": [
            "bean dregs",
            "draw the law in reflux",
            "corrosion inhibitor"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "PENG Xiao-hong",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "ZHANG Yan-fen",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "GAO Yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            }
        ],
        "venue": "Anhui Chemical Industry",
        "year": 2008
    },
    "6UxaQHwA": {
        "id": "6UxaQHwA",
        "title": "Research and Application of Carbon Dioxide Corrosion Inhibitor for Oil and Gas Well",
        "abstract": "The research and developing situation of carbon dioxide corrosion inhibitor used for oil and gas production industry were summarized.Much interest has been devoted to organic inhibitors such as triazole type compounds,imidazoline,amide derivatives,etc.in various media.Its inhibiting mechanisms and spot detection methods were introduced.The prospects of application were anticipated.The trend for further research and development was also discussed.",
        "keywords": [
            "Oil and gas well",
            "Inhibitor",
            "Development",
            "Carbon dioxide corrosion"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China;School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China"
            },
            {
                "name": "HAN Tian-li",
                "org": "School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China"
            },
            {
                "name": "LU Min-xu",
                "org": "School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China"
            },
            {
                "name": "WU Yin-shun",
                "org": "School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China"
            },
            {
                "name": "WU Wei-ming",
                "org": "School of Materials Science and Engineering,University of Science and Technology of Beijing,Beijing ,China;School of Materials and Chemical Engineering,Jiangxi University of Science and Technology,Ganzhou ,China"
            }
        ],
        "venue": "Surface Technology",
        "year": 2006
    },
    "L7gakExO": {
        "id": "L7gakExO",
        "title": "Spectrophotometric Determination of Gold in Ores by Extraction with Isoamyl-alcohol and Colouration with TMK-n-butyl-alcohol",
        "abstract": "A new determination method of gold in ores was studied.The sample is dissolved with aqua regia.The gold is extracted with isoamyl-alcohol and determinated by spectrophotometry with TMK-n-butyl-alcohol as colour reagent at pH = 4 in the media of acetic acid-sodium acetate.The Beer,s law is obeyed in the range of 0～5μg/5mL for gold.The results are satisfactory.",
        "keywords": [
            "Analytic chemistry",
            "Isoamyl-alcohol",
            "Gold",
            "Spectrophotometry"
        ],
        "authors": [
            {
                "name": "WU Weiming",
                "org": "Jiangxi University of Science and Technology,Ganzhou,Jiangxi ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Jiangxi University of Science and Technology,Ganzhou,Jiangxi ,China"
            },
            {
                "name": "DU Haiyan",
                "org": "Jiangxi University of Science and Technology,Ganzhou,Jiangxi ,China"
            },
            {
                "name": "LI Xudong",
                "org": "Jiangxi University of Science and Technology,Ganzhou,Jiangxi ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2006
    },
    "nkPYgsej": {
        "id": "nkPYgsej",
        "title": "Surface enhanced raman scattering and its application in research of corrosion inhibitor",
        "abstract": "Surface enhanced raman scattering(SERS)is an analyze method which can determine the molecular structure,it will has extensive application.The basic principle,characteristic and enhanced mechanism of surface enhanced raman scattering(SERS)are described.The application of surface enhanced raman scattering(SERS)in research of corrosion inhibitor also is introduced.The development status of surface enhanced raman scattering(SERS)is discussed.",
        "keywords": [
            "Corrosion inhibitor",
            "Surface enhanced raman scattering",
            "Application"
        ],
        "authors": [
            {
                "name": "Du Haiyan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "Zhang Yanfen",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "Gao Yan",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            },
            {
                "name": "Peng Xiaohong",
                "org": "Jiangxi University of Science and Technology,School of Materials and Chemical Engineering,Ganzhou ,China"
            }
        ],
        "venue": "Journal of Chemical Industry & Engineering",
        "year": 2008
    },
    "mxp8sVXQ": {
        "id": "mxp8sVXQ",
        "title": "Inhibition Performance of Amino Acids for Steel in Sulfuric Acid Solution",
        "abstract": "The inhibition effect of cystine and methionine on the corrosion of X65 steel in sulfuric acid solution (0.5mmol/L)was investigated using open-circuit potential measurements,polarization techniques and electrochemical impedance spectroscopy(EIS).The study revealed that the inhibitors had promising corrosion inhibition efficiency at low concentration and the inhibition efficiency(IE,%)increased with increasing the inhibitor's concentration.At the same concentration,cystine was more efficient than methionine.The corrosion inhibition effect was based on the adsorption of the amino acid molecules and/or the deposition of corrosion products on the metal surface.Polarization curves revealed that the inhibitors were mixed type inhibitors.",
        "keywords": [
            "sulfuric acid",
            "EIS",
            "methionine",
            "cystine",
            "corrosion inhibitor"
        ],
        "authors": [
            {
                "name": "WU Wei-ming",
                "org": "University of Science and Technology Beijing,Beijing ,China;Jiangxi University of Science and Technology,Ganzhou ,China"
            },
            {
                "name": "LU Min-xu",
                "org": "University of Science and Technology Beijing,Beijing ,China"
            },
            {
                "name": "CHENG Ming-yan",
                "org": "Jiangxi University of Science and Technology,Ganzhou ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Jiangxi University of Science and Technology,Ganzhou ,China"
            },
            {
                "name": "XU Li-ning",
                "org": "University of Science and Technology Beijing,Beijing ,China"
            }
        ],
        "venue": "Corrosion & Protection",
        "year": 2008
    },
    "TwyiPVvO": {
        "id": "TwyiPVvO",
        "title": "Establishment and Application of Universal PCR Method for Streptococcus",
        "abstract": "Streptococcus and other genera of bacteria were detected by PCR using a pair of universal primers designed and synthesized based on Streptococcus elongation factor EF-Tu gene to establish the fast detection method.Results showed that a 197 bp specific DNA fragment was amplified from Streptococcus suis type 2 and Streptococcus agalactiae by the universal primer designed,but it was negative for Staphylococcus aureus,S.epidermidis,Enterococcus faecalis,E.coli,Bacillus subtilis,Pseudomonas aeruginosa,Salmonella dublinand and Pasteurella multocida.Sequence analysis data of the PCR amplification products showed that amplified fragment had 90%~98% of homology with the sequence of Streptococcus in GenBank.Detection of different dilutions level of Streptococcus DNA test samples revealed that the minimum amount of PCR detection could be 0.1ng/mL.Desired target bands could be amplified from 11 isolates of Streptococcus,which had 100% of coincidental rate with class biochemical identification results.These results indicated that the PCR method was successfully established and applicable for the identification of clinical isolates for Streptococcus.",
        "keywords": [
            "streptococcus",
            "reaction system",
            "pcr",
            "genes",
            "dna",
            "polymerase chain reaction",
            "identification",
            "dna sequencing",
            "analytical methods"
        ],
        "authors": [
            {
                "name": "du haiyan",
                "org": ""
            },
            {
                "name": "li jizhong",
                "org": ""
            },
            {
                "name": "zhou bijun",
                "org": ""
            },
            {
                "name": "wang kaigong",
                "org": ""
            },
            {
                "name": "yang ying",
                "org": ""
            },
            {
                "name": "yin junlei",
                "org": ""
            },
            {
                "name": "wen ming",
                "org": ""
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2009
    },
    "Juhtif6c": {
        "id": "Juhtif6c",
        "title": "Isolation and Identification of Bacteria From Fermented Swine Manure",
        "abstract": "The fermented swine manure was used for isolation of bacteria by the dilution plate method,and the isolated strains were identified from morphology,cultivation and biochemical characteristics to obtain the deodorizing microorganisms.The results showed that five superior strains were obtained,which are Bacillus cereus,Bacillus subtilis,Bacillus pumilus,Lactobacillus acidophilus and Saccharomyces cerevisiae.The results laid a material foundation for preparation of deodorant of swine manure.",
        "keywords": [
            "swine manure",
            "isolation",
            "identification",
            "bacteria",
            "heap fermentation"
        ],
        "authors": [
            {
                "name": "GAO Ying",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou "
            },
            {
                "name": "LI Ji-zong",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou "
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou "
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ;Guizhou Laboratory for Animal Disease,Guiyang,Guizhou ,China"
            },
            {
                "name": "WEN Ming",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ;Guizhou Laboratory for Animal Disease,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2011
    },
    "vniPbRlc": {
        "id": "vniPbRlc",
        "title": "Construction and Identification of Eukaryotic Expression Vector of Goat Poxvirus P32 Gene",
        "abstract": "A pair of primers containing the restriction sites for BamHⅠand Hind Ⅲ was designed based on the previously reported sequence of the goat poxvirus P32 gene.The P32 gene DNA sequence was amplified by PCR from the Lab-kept bacterial strains.PCR products were double-digested by BamHⅠand Hind Ⅲ,then cloned into the eukaryotic expression vector pcDNA3.1(+).After identification by PCR amplification,double restriction digestion and sequencing,the recombinant expression vector pcDNA3.1(+)-P32/LD was successfully c onstructed.The experiment will provide help for future research in GPV P32 genetic vaccine and diagnostic method.",
        "keywords": [
            "P32 gene",
            "Goat poxvirus",
            "Eukaryotic expression vector",
            "pcDNA3.1(+)"
        ],
        "authors": [
            {
                "name": "YIN Jun-lei",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,;2.Key Laboratory for Amimal Epidemic Disease of Guizhou,Guiyang ,China"
            },
            {
                "name": "WEN Ming",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,;2.Key Laboratory for Amimal Epidemic Disease of Guizhou,Guiyang ,China"
            },
            {
                "name": "CHENG Zhen-tao",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,;2.Key Laboratory for Amimal Epidemic Disease of Guizhou,Guiyang ,China"
            },
            {
                "name": "FAN Cui-hua",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,"
            },
            {
                "name": "YANG Ying",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,"
            },
            {
                "name": "DU Hai-yan",
                "org": "1.College of Animal Science,Guizhou University,Guiyang ,China,"
            }
        ],
        "venue": "Journal of Henan Agricultural Sciences",
        "year": 2010
    },
    "WLvotfay": {
        "id": "WLvotfay",
        "title": "Construction and Immune Effect of DNA Vaccine Based on Gapc Gene of Streptococcus",
        "abstract": "Streptococcus Gapc gene was amplified by PCR and cloned into the eukaryotic expressing plasmid pcDNA3.1 to construction the recombinant vector.After identification by PCR and restriction enzyme digestion,this vector was transfected into Vero cells and its expression was observed by fluorescent antibody test,and the serum antibodies and protetive effect against bacterial attack were detected in mice injected with the recombinant vector.The results showed as follow: the expected DNA fragments(1 011 bp and 5 500 bp) were digged out by PCR and enzyme digestion from the recombinant vector,and the fragment of 1011bp was confirmed as the Gapc gene of Streptococcus by sequencing.The Gapc gene was effectively expressed in the Vero cells.The anti-Gapc antibodies counld be detected in mice of 7 day,and reached the peak of antibody level on 35 day,then decreased gradually,but maintained a high level,which existed a significant difference(P<0.01) in comparison with the control groups.When attacked by bacteria,the clinical symptoms of mice in the immuned group were mild and recoveried quickly,and its lesion only confined in liver and kinney,and the amount of bacteria was 3.05log in the spleen,which existed obvious difference(P<0.01) compared with that of the control.The above results indicated that the DNA vaccine based Gapc gene of Streptococcus was successfully constructed in this experiment,which could induce a high antibody level in mice and playa protective effect in mice against Streptococcus attack.",
        "keywords": [
            "Streptococcus",
            "DNA vaccine",
            "construction",
            "immunine effect",
            "Gapc gene"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            },
            {
                "name": "ZHANG Xia",
                "org": "Luodian Country Centre for Animal Diseases Prevention and Control,Luodian,Guizhou,,China"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China;Laboratory for Amimal Disease of Guizhou,Guiyang,Guizhou,,China"
            },
            {
                "name": "WEN Ming",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China;Laboratory for Amimal Disease of Guizhou,Guiyang,Guizhou,,China"
            }
        ],
        "venue": "Progress in Veterinary Medicine",
        "year": 2011
    },
    "nGislqra": {
        "id": "nGislqra",
        "title": "Investigation and Analysis of Bacteria in the Environment of the Scaled Farm",
        "abstract": "To grasp the number and species of bacteria in the surrounding environment of the scaled pig farm and provide the basis for prevention and control of the bacterial disease of pig, the air, drinking and sewage water, faecal and soil samples were collected for bacteriological isolation and identification which from two-scale pig farms in Guizhou province. The results showed that the numbers of bacteria were respectively 1.17×104 to 94.40×104, 0.15×102 to 1.83×102, 5.00×105 to 32.00×105, 0.46 ×106 to 26.40×106 and 0.30×105 to 52.30×105 CFU/g in the above-mentioned samples, and of these bacteria, there were mainly Staphylococcus, Streptococcus, Escherichia, Salmonella, Yersinia, Proteus, Pasteurella, Listeria, Bacillus, Clostridium and so on. The results suggested that the numbers of bacteria in the other samples except drinking water and soil, were in line with requirement of national regulation for livestock and pourty farms, while there were some conditioned pathogen or pathogen,and these investigations provided an important reference data for prevention and control of pig bacterial diseases.",
        "keywords": [
            "bacterial number",
            "investigation",
            "scaled farm",
            "bacterial species"
        ],
        "authors": [
            {
                "name": "LI Ji-zong",
                "org": "\tCollege of Animal Science,Guizhou University, Guiyang , China"
            },
            {
                "name": "GAO Ying",
                "org": "\tCollege of Animal Science,Guizhou University, Guiyang , China"
            },
            {
                "name": "DU Hai-yan",
                "org": "\tCollege of Animal Science,Guizhou University, Guiyang , China"
            },
            {
                "name": "WANG Kai-gong",
                "org": "\tCollege of Animal Science,Guizhou University, Guiyang , China"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "\tCollege of Animal Science,Guizhou University, Guiyang , China"
            },
            {
                "name": "WEN Ming",
                "org": "\tCollege of Animal Science,Guizhou University, Guiyang , China"
            }
        ],
        "venue": "China Animal Husbandry & Veterinary Medicine",
        "year": 2010
    },
    "m7xYueDp": {
        "id": "m7xYueDp",
        "title": "Detection of virulent DEV NP gene in artificial infected ducklings using SYBR GreenⅠ real-time PCR",
        "abstract": "To observe the expression levels of DEV NP gene in the various organizations of 15-day-old ducklings infected intramuscularly with virulent DEV strain GZ,SYBR GreenⅠreal-time quantitative PCR was used to detect the transcripts expression levels of NP gene.The results indicated that the NP gene could be detected in six tissues including liver,spleen,brain,thymus,kidney and lung at 3 h post-infecion(PI),and in duodenum and cecum beside the above six tissues at 6 h PI,then in pectoral muscle and cardiac muscle beside the above eight tissues at 10 h PI.The expression levels detected were various in different organizations,and reached a peak at 30 h or 48 h PI,continuing until 96 h,then all declined.These results provided a theoretical basis for clarification of pathogenic mechanism of DEV,and made the foundation for the study of the relationship between pathogen and ducks.",
        "keywords": [
            "ducklings",
            "real-time PCR",
            "duck plague",
            "nucleocapsid protein gene"
        ],
        "authors": [
            {
                "name": "YANG Ying",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ,China"
            },
            {
                "name": "XIA Meng",
                "org": "Xiangxi Breeding Stork Farm,Jishou,Hu'nan ,China"
            },
            {
                "name": "YIN Jun-lei",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ,China"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ,China"
            },
            {
                "name": "WEN Ming",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Acta Agriculturae Zhejiangensis",
        "year": 2011
    },
    "DtQamK9P": {
        "id": "DtQamK9P",
        "title": "Detection of virulent Duck Plague Virus in Artificial Infected Ducklings by Real-time PCR",
        "abstract": "The dynamic distribution of duck enteritis virus(DEV) in the various organzitions of 15-day-old ducklings,which infected intramuscularly with virulent DEV strain GZ,were detected by SYBR GreenⅠfluorescence quantitative PCR.The results indicated that the DEV DNA could be detected in six tissues of liver,spleen,brain,thymus,kidney and lung at 3 hours post-infetion(PI),and in duodenum and appendix beside above six tissues at 6 hours PI,then in breast muscle and cardiac muscle beside above eight tissues at 10 hours PI.The amount of DEV DNA was varied in the different organis of ducklings,ranked as brain,liver,spleen,thymus,kidney,duodenum,appendix,lung,breast muscle and cardiac muscle.These results provided an important experimental data for clarification of pathogenic mechanism of DEV.",
        "keywords": [
            "duckling",
            "Duck plague virus",
            "real-time FQ-PCR",
            "distribution"
        ],
        "authors": [
            {
                "name": "YANG Ying",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            },
            {
                "name": "XIA Meng",
                "org": "Xiangxi Breeding Stork Farm,Jishou,Hu'nan,,China"
            },
            {
                "name": "YIN Jun-lei",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            },
            {
                "name": "MAO Jun-ting",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            },
            {
                "name": "WEN Ming",
                "org": "College of Animal Science,Guizhou University,Guiyang,Guizhou,,China"
            }
        ],
        "venue": "Progress in Veterinary Medicine",
        "year": 2010
    },
    "3K1Jmo5T": {
        "id": "3K1Jmo5T",
        "title": "Construction and Indentification of Eukaryotic Expression Vector of Goat poxvirus P32 Gene using Attenuated Salmonella typhimurium as Carrier",
        "abstract": "Objective:Construction and Indentification of Eukaryotic expression vector of Goat poxvirus P32 Gene using Attenuated Salmo-nella typhimurium as carrier.Method:The P32 gene was cloned from the plasmid pMD-18T-P32/LD by polymerase chain reaction ( PCR) and inserted into the vector pVAX1.This recombinant plasmid pVAX1-P32/LD was identified by digestion of endonuclease,PCR and sequencing.Result:The results confirmed that recombinant at tenuated Salmonella typhimurium vaccine S7207/pVAX1-P32/LD was constructed succeed.Conclusion:The experiment will provide help for future research in GPV P32 genetic vaccine and diagnostic meth-od.",
        "keywords": [
            "P32 gene",
            "Goat poxvirus",
            "pVAX1",
            "recombinant attenuated Salmonella typhimurium",
            "eukaryotic expression vector"
        ],
        "authors": [
            {
                "name": "YIN Jun-lei",
                "org": "College of Animal Science,Guizhou University"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "College of Animal Science,Guizhou University;Key Laboratory for Amimal Epidemic Disease of Guizhou,Guiyang ,China"
            },
            {
                "name": "WEN Ming",
                "org": "College of Animal Science,Guizhou University;Key Laboratory for Amimal Epidemic Disease of Guizhou,Guiyang ,China"
            },
            {
                "name": "FAN Cui-hua",
                "org": "College of Animal Science,Guizhou University"
            },
            {
                "name": "YANG Ying",
                "org": "College of Animal Science,Guizhou University"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Animal Science,Guizhou University"
            }
        ],
        "venue": "Biotechnology",
        "year": 2010
    },
    "TkdvG47d": {
        "id": "TkdvG47d",
        "title": "Detection and Sequence Analysis of Glyceraldehyde-3-phosphate Dehydrogenase Gene of Streptococcus",
        "abstract": "A pair of primer was synthesized based on the published Streptococcus suis type 2 glyceraldehyde-3-phosphate dehydrogenase gene(Gapc) and PCR was applied to detect 10 Streptococcus strains.The amplified products were cloned and sequenced.The results showed that the Gapc gene of 8 Streptococcus strains was detected in all tested strains.The Gapc gene of the above 4 strains were sequenced and analysised by BLAST and DNAStar with pubished Streptococcus Gapc in GenBank.The nucleotide homology of them was 85.3% to 98.3% and the amino acid homology was 87.2% to 99.4%.It had many domains of high antigen index and hydrophilicity and surface probability plot and Gapc gene in Streptococcus was conservative.The results indicated that the Gapc may be applied into clinical prevention for Streptococci infections.",
        "keywords": [
            "Streptococcus",
            "detection",
            "sequence analysis",
            "Gapc gene"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "Institute of Animal Diseases,College of Animal Science of Guizhou University,Guiyang ,China"
            },
            {
                "name": "LI Xia-yun",
                "org": "Institute of Animal Diseases,College of Animal Science of Guizhou University,Guiyang ,China"
            },
            {
                "name": "CHENG Zhen-tao",
                "org": "Institute of Animal Diseases,College of Animal Science of Guizhou University,Guiyang ,China"
            },
            {
                "name": "WEN Ming",
                "org": "Institute of Animal Diseases,College of Animal Science of Guizhou University,Guiyang ,China"
            },
            {
                "name": "ZHOU Bi-jun",
                "org": "Institute of Animal Diseases,College of Animal Science of Guizhou University,Guiyang ,China"
            },
            {
                "name": "WANG Kai-gong",
                "org": "Institute of Animal Diseases,College of Animal Science of Guizhou University,Guiyang ,China"
            }
        ],
        "venue": "China Animal Husbandry & Veterinary Medicine",
        "year": 2011
    },
    "9GkJhpWu": {
        "id": "9GkJhpWu",
        "title": "Pharmacokinetics of aranidipine enteric capsules in healthy Chinese volunteers",
        "abstract": "Objective: To determine the pharmacokinetic(PK) characteristics of aranidipine(AR) and its active metabolite hydroxyl-aranidipine(AR-M1) after single and multiple doses of AR enteric capsules in healthy Chinese volunteers.Methods: Totally 36 subjects were randomly assigned to receive AR 5,10 or 20 mg once for the single dose study.In addition,the subjects in 10 mg group received 10 mg,qd for another 7 days for a multiple dose study.The plasma concentrations of AR and AR-M1 were determined by LC-MS/MS,and the parameters were calculated using DAS 2.1.1 software.Results: The elimination half-life(t1/2z) of AR and AR-M1 after po AR 5~20 mg were about 2.0~2.7 h and 3.9~5.6 h.Cmax of AR and AR-M1 increased linearly from(2.12±1.14) to(11.34±5.98) μg·L-1 and(29.41±9.80) to(111.74±24.03) μg·L-1 with the increasing dose.AUC also increased linearly within the dose range of 5~20 mg.AUC0~t of AR and AR-M1 were [(6.02±2.96) to(30.33±8.88) μg·h·L-1] and [(156.05±32.24) to(776.00±160.47) μg·h·L-1],and AUC0~∞ were [(6.12±2.98) to(30.53±8.89) μg·h·L-1] and [(159.39±33.23) to(785.53±161.92) μg·h·L-1],respectively.The pharmacokinetic parameters of AR and AR-M1 in AR 10 mg multiple doses study were as follows: t1/2z about 2.5 and 5.5 h,AUC0~t(18.09±5.42) and(604.46±159.66) μg·h·L-1,AUC0~∞(18.25±5.42) and(611.93±162.81) μg·h·L-1,respectively.Conclusion: AR and AR-M1 exhibit linear pharmacokinetic profiles in AR dose range from 5 to 20 mg.The Cmax and AUC of multiple-dose regimen are significantly increased compared with the single dose regimen.The accumulation of AR and AR-M1 is not significant.",
        "keywords": [
            "aranidipine",
            "liquid chromatography-tandem mass spectrometry",
            "hydroxyl-aranidipine",
            "plasma concentration",
            "pharmacokinetics"
        ],
        "authors": [
            {
                "name": "LIN Yang",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "Li Jing",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Han-yue",
                "org": " Jiang Su De Yuan Pharmaceutical Co.,Ltd.,Lianyungang ,China"
            },
            {
                "name": "ZHOU Zi-jie",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Ke-xu",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WU Wei",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUO Wei",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHAO Gui-ping",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "FANG Shan-juan",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "JIE Bing-zhang",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "YAN Xiu-juan",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "JIA Xiao-xin",
                "org": " Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2012
    },
    "zfHL6OJN": {
        "id": "zfHL6OJN",
        "title": "Utilization of Lipid-regulating Agents During 2008-2010 Period",
        "abstract": "OBJECTIVE:To investigate the utilization of lipid-regulating agents in our hospital for references of clinical management and rational use of this category of drugs.METHODS:The utilization data such as consumption sum and quantity of lipid-regulating agents in our hospital during 2008-2010 were investigated for statistically analysis regarding the consumption sum,annual DDDs and DDC by methods of consumption analysis and DDDs analysis.RESULTS:The consumption sum of lipid-regulating agents increased by about 30% annually,and the DDDs showed good synchronism.Statins were the dominant lipid-regulating agents in our hospital.Ethyl polyenoate soft capsule ranked only second to atorvastatin and simvastatin in DDDs.CONCLUSION:The use of lipid-regulating agents in our hospital was rational and under well control.The lipid-regulating agents with good therapeutic effects and low price hold a promising future.",
        "keywords": [
            "DDC",
            "Analysis of drug use",
            "DDDs",
            "Lipid-regulating agents",
            "Consumption sum"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "Dept.of Pharmacy,Capital Medical University Affiliated Beijing Anzhen Hospital"
            },
            {
                "name": "LIN Yang",
                "org": "Clinical Drug Trial Agency,Beijing ,China"
            }
        ],
        "venue": "Evaluation and Analysis of Drug-Use in Hospitals of China",
        "year": 2011
    },
    "VoNYVdu5": {
        "id": "VoNYVdu5",
        "title": "Determination of Bivalirudin in Human Blood by HPLC-MS/MS",
        "abstract": "OBJECTIVE To establish an HPLC-MS /MS method for the determination of blood-bivalirudin concentration.METHODS Following a SPE method,the analytes were separated on a C 18 column interfaced with a triple-quadrupole tandem mass spectrometer using positive electrospray ionization.RESULTS The calibration linear rang of blood-bivalirudin concentration was 25-20 000 μg·L-1(r = 0.996 9).The between-day and within-day RSD% were less than 6.63%.The recoveries were more than 80%.CONCLUSION The rapid,sensitive and reliable HPLC-MS / MS method can be applied to monitor blood-bivalirudin profile.",
        "keywords": [
            "SPE",
            "HPLC-MS/MS",
            "bivalirudin"
        ],
        "authors": [
            {
                "name": "LI Jing",
                "org": ""
            },
            {
                "name": "LIN Yang",
                "org": ""
            },
            {
                "name": "WU Wei",
                "org": ""
            },
            {
                "name": "ZHAO Gui-ping",
                "org": ""
            },
            {
                "name": "SUO Wei",
                "org": ""
            },
            {
                "name": "DU Hai-yan",
                "org": ""
            },
            {
                "name": "QIU Qi",
                "org": ""
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2013
    },
    "az6IaJNs": {
        "id": "az6IaJNs",
        "title": "Determination of Pilsicainide in Human Plasma and Urine by LC-MS /MS",
        "abstract": "OBJECTIVE To develop a sensitive and specific LC-MS /MS method for the determination of pilsicainide in human plasma and urine. METHODS The samples were processed by LLE( liquid-liquid extraction),acetonitrile-ammonium acetate( 0. 1‰ formic acid)-water was used as the mobile phase with isocratic elution( 25∶ 37. 5∶ 37. 5 in plasma,35 ∶ 6 ∶ 59 in urine),and separation was carried out on Welch Material Ultimate AQ-C18column( 2. 1 00 × 100 mm,3. 5 μm),setting the flow rate as 0. 35 mL·min-1,the column temperature at 25 ℃. The injection volume was 5 μL. ESI under positive ion mode and multiple reaction monitoring scan( MRM) were used for quantitative analysis with m / z 273. 4→110. 2 for pilsicainide and m/z 287. 4 →110. 2 for internal standard,methyl-pilsicainide. RESULTS The linear ranges of the calibration curves for pilsicainide were 1-1 200 μg·L-1for plasma and 1-150 mg·L-1for urine. The limitation of detection were 1 μg·L-1for plasma and 1 mg · L-1for urine. The correlation coefficient was between 0. 996 2 and 0. 999 1. The extraction recoveries,matrix effects,and intra-/ inter-assay precisions all met the requirements of pharmacokinetic studies. This approach was applied to determine pilsicainide concentrations in human plasma and urine in a clinical pharmacokinetic research. CONCLUSION This approach possesses convenience,accuracy,high sensitivity and good reproducibility,which can meet the requirements of pharmacokinetic studies.",
        "keywords": [
            "plasma drug concentration",
            "urine drug concentration",
            "HPLC-MS /MS",
            "pilsicainide"
        ],
        "authors": [
            {
                "name": "SUO Wei",
                "org": ""
            },
            {
                "name": "LI Jing",
                "org": ""
            },
            {
                "name": "LIN Yang",
                "org": ""
            },
            {
                "name": "WEI Yong-xiang",
                "org": ""
            },
            {
                "name": "YANG Ke-xu",
                "org": ""
            },
            {
                "name": "QIU Qi",
                "org": ""
            },
            {
                "name": "WU Wei",
                "org": ""
            },
            {
                "name": "ZHAO Gui-ping",
                "org": ""
            },
            {
                "name": "DU Hai-yan",
                "org": ""
            },
            {
                "name": "ZHOU Zi-jie",
                "org": ""
            },
            {
                "name": "ZHANG Ying-chao",
                "org": ""
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2013
    },
    "td5wijNE": {
        "id": "td5wijNE",
        "title": "Preliminary pharmacokinetic and pharmacodynamic studies and safety evaluation of homemade bivalirudin in 10 healthy male subjects",
        "abstract": "Objective To study pharmacokinetic and pharmacodynamic characteristics of homemade bivalirudin in healthy male subjects and evaluate its safety preliminarily in order to provide the scientific basis for a phase Ⅱ/Ⅲ clinical trial and clinical use of the drug.Methods Healthy male subjects were collected and received a single intravenous bolus injection of bivalirudin 0.75 mg/kg.Plasma concentrations of bivalirudin within 180 min after injection were determined by liquid chromatography-tandem mass spectrometric(LC-MS/MS) method for pharmacokinetic analysis.The activated clotting time were measured for pharmacodynamic analysis.At the same time,the vital signs and safety evaluation indexes were observed in all subjects before and after medication.Results Ten healthy male subjects were entered.Their age,height,weight,and body mass index were(29.5±3.4) years,(170.7±5.5) cm,(66±7) kg,and(22.2±1.7) kg/m2,respectively.The pharmacokinetic parameters were as follows: peak concentration(Cmax)(8347±1586) μg/L,peak time(Tmax) 5 min,elimination half-life(T1/2z)(41.6±9.0) min,area under the curve(AUC0-t)124.0(98.4-182.3) min·μg/L,area under the curve(AUC0-∞)(131.9±26.8) min·μg/L,mean retention time(MRT0-t)(25.6±3.1) min,volume of distribution(Vz)(354.8±103.9) ml/kg,clearance(CL)(5.9±1.1)ml/(min·kg).The pharmacodynamic parameters were as follows: basic effect(E0)(146±17) s,concentration for 50% of maximal effect(EC50)2225(799-42 008) μg/L,maximal effect(Emax)(4072±294) s.No changes in X-ray,cranial CT,12-lead ECG and laboratory examination(routine blood and urine tests,blood biochemical tests,immunological tests,5 tests of coagulation) were observed after the trail.No adverse drug reaction occurred during the trial.Conclusion Homemade bivalirudin seems to have the characteristics of rapid onset of action and shorter half-life and might be used as a safer anticoagulant in patients undergoing percutaneous coronary intervention.",
        "keywords": [
            "activated clotting time",
            "pharmacodynamics",
            "pharmacokinetics",
            "bivalirudin"
        ],
        "authors": [
            {
                "name": "YANG Ke-xu",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIN Yang",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Jing",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUO Wei",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WU Wei",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "QIU Qi",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHOU Zi-jie",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHAO Gui-ping",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Yun-long",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "PAN Yu",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "YAN Xiu-juan",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "JIA Xiao-xin",
                "org": ".Drug Clinical Trail Institution,Beijing Anzhen Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Adverse Drug Reactions Journal",
        "year": 2012
    },
    "aIMU9Ng2": {
        "id": "aIMU9Ng2",
        "title": "Research Progress on Statins and Evaluation on Its Clinical Application",
        "abstract": "OBJECTIVE:To evaluate the research progress on statins in order to provide references for clinicians about rational drug use.METHODS:By reviewing the pertinent literature both at home and abroad,a systematic meta-analysis was performed on the research progress on statins.RESULTS & CONCLUSION:Statins can not only lower cholesterol levels,but also play a role in the treatment of coronary atherosclerotic heart disease,cerebral ischemic stroke,diabetic angiopathy,arrhythmia,alzheimer disease and hypertension etc through ameliorating the endothelial function of blood vessels,inhibiting platelet aggregation and formation of thrombus,stabilizing atherosclerotic plaque,inhibiting proliferation and migration of smooth muscle cells as well as its anti-inflammatory and antioxidative action.In China,statins were poorly used in patients coronary artery disease,indicating the necessity to transform the evidence in evidenced-based medicine in this filed to scientific and standard clinical practice.",
        "keywords": [
            "Statins",
            "Adverse drug reaction",
            "Research progress",
            "Clinical application"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "Dept.of Pharmacy,Capital Medical University Affiliated Beijing Anzhen Hospital,Clinical Trial Agency for Drugs,Beijing ,China"
            },
            {
                "name": "LIN Yang",
                "org": "Dept.of Pharmacy,Capital Medical University Affiliated Beijing Anzhen Hospital,Clinical Trial Agency for Drugs,Beijing ,China"
            }
        ],
        "venue": "Evaluation and Analysis of Drug-Use in Hospitals of China",
        "year": 2011
    },
    "Hej1fd3T": {
        "id": "Hej1fd3T",
        "title": "Effects of High-Fat Meal on the Pharmacokinetic and Pharmacodynamic Properties and Safety Profile of Aranidipine Enteric-Coated Capsule in Healthy Chinese Subjects",
        "abstract": "OBJECTIVE To assess the effects of high-fat meal on the pharmacokinetic(PK) and pharmacodynamic(PD) properties and safety profile of aranidipine(AR) and its active metabolite,hydroxyl-aranidipine(AR-M1),in health Chinese subjects.METHODS One single-dose,open-label,randomized,crossover study of oral aranidipine enteric-coated capsule was conducted in healthy Chinese subjects.Twelve healthy nonsmoking subjects(6 males,6 females) aged from 18 to 45 years were orally administrated aranidipine enteric-coated capsule 10 mg in fasted state.After a washout period of 1 week,the subjects were orally administrated aranidipine enteric-coated capsule 10 mg after high-fat breakfast.Plasma samples were collected previous to the administration as well as at indicated time points after the administration.Concentrations of AR and AR-M1 in plasma were determined by HPLC-MS/MS.PK parameters(AUC0-t,AUC0-∞,ρmax,tmax,t1/2,Ke,CL/F,Vd/F,etc.) of AR and AR-M1 were calculated with DAS 2.1.1.Systolic and diastolic blood pressure(SBP and DBP) and heart rate(HR) were measured before and at indicated time points after the administration.Safety profile assessment was performed throughout the experiment.RESULTS There was significant increase in AUC0-t,AUC0-∞,and tmax for AR given after high-fat meal compared with those in fasted condition(P<0.05).For AR-M1,there was extremely significant increase in tmax(P<0.01) under high-fat meal condition and no significant difference in other parameters(P>0.05).There were no significant changes in BP and HR after the administration in a high-fat meal state compared with that in fasted state.Compared with baseline,there was significant decrease in DBP at 8 h after the administration in both fasted and high-fat meal state(P<0.05).CONCLUSION Oral administration of aranidipine enteric-coated capsule after high-fat meal results in slow absorption and significant increase in bioavailability of AR,as well as significant delay in the generation of AR-M1.There were no significant changes in BP and HR after the administration in either fasted or high-fat meal state.No serious AEs were observed during the experiment,showing the good safety profile of the agent.There is no need to adjust the dosage in clinic application,but light-food and administration in fasted state are recommended.",
        "keywords": [
            "safety profiles",
            "pharmacodynamics",
            "aranidipine",
            "hydroxyl-aranidipine",
            "pharmacokinetics",
            "high-fat meal"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Yue-han",
                "org": "Jiangsu DeYuan Pharmaceutical Co.,LTD,Lianyungang ,China"
            },
            {
                "name": "LI Jing",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Ke-xu",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIN Yang",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WU Xue-si",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "JIE Bing-zhang",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "FANG Shan-juan",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YAN Xiu-juan",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "JIA Xiao-xin",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHOU Zi-jie",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WU Wei",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUO Wei",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHAO Gui-ping",
                "org": "Phase I Clinical Trial Laboratory of Beijing Anzhen Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2011
    },
    "GsnWEcSz": {
        "id": "GsnWEcSz",
        "title": "White upconversion emission in Li+/Yb3+/Tm3+/Er3+-doped Gd6MoO12 phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "bing xue",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Optics Communications",
        "year": 2013
    },
    "snfXPkRL": {
        "id": "snfXPkRL",
        "title": "Synthesis, structure and luminescence properties of Y(V,P)O 4 :Eu 3+ ,Bi 3+ phosphors",
        "abstract": "",
        "keywords": [
            "quantum efficiency",
            "emission line",
            "energy transfer",
            "photoluminescence"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "jianbo xian",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            },
            {
                "name": "haiyan du",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2010
    },
    "bfzYzvr4": {
        "id": "bfzYzvr4",
        "title": "Luminescence properties of novel red phosphor NaSrPO 4:Eu 3+",
        "abstract": "A novel red-emitting NaSrPO4:Eu3+ phosphor was prepared by a conventional solid-state reaction. The luminescence properties and temperature dependence of NaSrPO4:Eu3+ were investigated. The phosphor exhibited red luminescence under the near-UV excitation of 395 nm, corresponding to the F-5(0)-> L-7(6) transition of Eu3+ ions, which matched well with the excitation wavelength of near-UV LED chips. The electronic transition due to D-5(0)-> F-7(2) transition of Eu3+ ions is stronger than the magnetic dipole transition due to D-5(0)-> F-7(1) of Eu3+ ions. Furthermore, Eu3+-doped NaSrPO4 phosphor shows higher thermally stable luminescence comparable to commercially available Y3Al5O12:Ce3+ phosphor. All the investigated suggested that this newly developed phosphor could find applications in white light devise utilizing InGaN-based excitation in the near-UV chips.",
        "keywords": [
            "red phosphor",
            "luminescence",
            "white LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "PROGRESS IN NEW MATERIALS AND MECHANICS RESEARCH",
        "year": 2012
    },
    "gVU6xJRR": {
        "id": "gVU6xJRR",
        "title": "Thermally stable blue NaBaPO 4: Eu 2+ phosphor synthesized by combustion method",
        "abstract": "A blue-emitting phosphor, NaBaPO4:Eu2+, was prepared by solution combustion synthesis method, and its luminescence properties were investigated in detail. It was found that NaBaPO4:Eu2+ could be efficiently excited by the UV-visible light of 230-420 nm and exhibited bright blue emission, which matched well with the emission wavelength of near-UV LED chips. NaBaPO4:Eu2+ showed high thermally stable luminescence compared to commercial phosphor YAG:Ce3+. With the increase of the temperature, the normalized emission intensity of NaBa0.98PO4:0.02Eu(2+) decreased to 92.3% of the initial value at 423 K, and the emission band exhibited a little blue-shift.",
        "keywords": [
            "NaBaPO4: Eu2+",
            "Combustion synthesis",
            "Thermal quenching",
            "white LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "MANUFACTURING SCIENCE AND TECHNOLOGY, PTS 1-3",
        "year": 2011
    },
    "8IVwuG8G": {
        "id": "8IVwuG8G",
        "title": "Hydrothermal synthesis and the enhanced blue upconversion luminescence of NaYF4:Nd3+,Tm3+,Yb3+",
        "abstract": "",
        "keywords": [
            "energy transfer",
            "luminescence",
            "nayf4:nd3+",
            "tm3+",
            "yb3+",
            "upconversion"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": ""
            },
            {
                "name": "Weihang Zhang",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            },
            {
                "name": "Zhiping Yang",
                "org": ""
            }
        ],
        "venue": "Infrared Physics & Technology",
        "year": 2010
    },
    "K15blOGN": {
        "id": "K15blOGN",
        "title": "Synthesis and spectral analysis of Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 phosphor to achieve white upconversion luminescence",
        "abstract": "",
        "keywords": [
            "near infrared",
            "x ray diffraction",
            "chemical composition"
        ],
        "authors": [
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            },
            {
                "name": "wei zhou",
                "org": "beijing technology and business university"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            },
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2010
    },
    "UxHGIAYI": {
        "id": "UxHGIAYI",
        "title": "Synthesis and study on its luminescence properties of (CaO-CaCl_2-SiO_2):Eu~(2+)",
        "abstract": "Eu2+-doped alkali earth chlorosilicate phosphor of the types (CaO-CaCl2-SiO2)∶Eu2+ was synthesized through the high temperature solid state method.Its structure and luminescence properties were investigated by using X-ray diffraction (XRD),excitation and emission spectra.Under the excitation of the near-ultraviolet (UV) light (350-420nm),the (CaO-CaCl2-SiO2)∶Eu2+ phosphor synthesized at 900℃ emits an intense green light peaking at 510nm,whereas the same component phosphor synthesized at 1100℃ emits an yellow light peaking at 582nm.In addition,luminescence properties and crystal-lattice environment of Eu2+ in (CaO-CaCl2-SiO2) crystal synthesized at 1100℃ were discussed according to the Van Uitert experimental equation and the possibilities of two Eu2+ emission centers,viz,green and yellow centers were confirmed.The mechanisms of concentration quenching in (CaO-CaCl2-SiO2)∶Eu2+ phosphor were also discussed,which were caused by the energy transfer among the nearest-neighbor ions in this phosphor system.",
        "keywords": [
            "concentration quenching",
            "luminescence",
            "WLEDs"
        ],
        "authors": [
            {
                "name": "SUN Jian-feng",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Journal of Functional Materials",
        "year": 2010
    },
    "goJBDRz8": {
        "id": "goJBDRz8",
        "title": "Upconversion luminescence properties of NaYF4: Tm3+ , Yb3+ synthesized by co-precipitation method",
        "abstract": "The upconversion (UC) processes of infrared light to visible light of rare earth ions doped different hosts have been investigated extensively, due to their potential applications in some fields, such as solid-state lasers, display, communications, and so on. The recent researches emerging at the intersection of nanotech-nology and biotechnology are opening up a new period for the development of UC. As known, the controlled fabrication of a host with aimed structure is important for enhancing the upconversion efficiency, because the phonon energy of the host can affect the probabilities of non-radiative decay and die energy transfer. There-fore, it is necessary to choose a lattice with much lower phonon energy, which is benefit to the upconversion luminescence. Rare earth-doped hexagonal sodium yttrium fluoride (NaYF 4) is a good host, which is known to be a very efficient near-infrared to visible upconverter. The hexagonal NaYF4has low phonon energy. The structure of hexagonal phase gives rise to controversy about the cation sites and distribution. The trivalent thu-lium (Tm3+) is an ideal candidate for single wavelength NIR upconversion due to its ladder of nearly equally spaced energy levels that are multiples of the 1G 4→3H6transition. The development of compact blue lasers based on Tm3+ upconversion processes is nowadays widely studied mainly due to the potential of high perfor-mance OEM applications, such as biomedical and analytical instrumentation, display, photoprinting. In thu-lium doped media, the efficiency of this process is very low, but it was noticed that the mechanism could be made one or two orders of magnitude more efficient by using ytterbium (Yb3+). In this paper, trivalent thu-lium (Tm3+) and yttebium (Yb3+) ions codoped NaYF4 were synthesized by co-precipitation method. The concentration of Tm3+ and Yb3+ are 0.01% , 0.1% , respectively. The absorption spectrum of NaYF4:Tm3+,Yb3+ from 300 to 1 100 nm was measured at room temperature. The upconversion emission was observed when excited by 798 nm. The green and blue upconversion emission spectra were measured. Based on the experi-mental results the possible upconversion mechanism was analyzed. The main mechanism is the in-direct sensi-tization of Tm3+andYb3+. The blue emitting light results from the transition of 1G4→1H6 of Tm3+, green emitting light is from the transition of 1D2→3F4 of Tm3+. To our knowledge, there have not been similar works published domestically and abroad. The structural properties of the samples were characterized by X-ray dif-fraction (XRD) and scanning electron microscopy (SEM). The results show that NaYF4: Tm 3+, Yb pre-pared by co-precipitation method exhibits hexagonal crystal phase.",
        "keywords": [
            "Co-precipitation method",
            "Indirect sensitization",
            "NaYF4: Tm3+",
            " Yb3+",
            "up-conversion luminescenee"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiping Yang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of Luminescence",
        "year": 2009
    },
    "3z3nw7MW": {
        "id": "3z3nw7MW",
        "title": "Preparation of Fe-Ti System Optically Variable Pigments by Wet Chemical Method",
        "abstract": "The optically variable pigments were produced by wet chemical method, and Ti coated mica having interference colors acted as host materials. The phase of the pigment was characterized by XRD, and its optically variable effect was investigated by CIE chromatic coordinate and the improved UV-VIS spectrometry. The impact of the pretreatment of Ti coated mica and the experiment conditions on improving the color travel effect was studied,and there are relation, between color travel effect. The results show that optically variable pigments can be prepared by coating Fe_2O_3 on the pretreated Ti coated mica, the reaction temperature is between 70℃to 80℃,the pH is between 2.8 to 3.5,the feeding rate is between 1 to 2 drop per minute, the calcine temperature is 850℃and the time is 40min,and optically variable pigments with different colors can be produced by changing different host.",
        "keywords": [
            "Ti coated mica",
            "wet chemical method",
            "pigments",
            "optically variable"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Environmental Engineering , Beijing Technology and Business University, Beijing "
            },
            {
                "name": "CHEN Qi-rong",
                "org": "College of Chemical and Environmental Engineering , Beijing Technology and Business University, Beijing "
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical and Environmental Engineering , Beijing Technology and Business University, Beijing "
            },
            {
                "name": "LI Ning",
                "org": "Beijing Ganghua Auxiliary Ltd.Co.,Beijing "
            }
        ],
        "venue": "Bulletin of the Chinese Ceramic Society",
        "year": 2006
    },
    "DamQAMM1": {
        "id": "DamQAMM1",
        "title": "SYNTHESIS AND UPCONVERSION PROPERTIES OF LiLa(MoO_4)_2:Yb~(3+),Er~(3+)(Tm~(3+))",
        "abstract": "Upconversion materials LiLa(MoO4)2:Yb3+,Er3+(Tm3+) were synthesized by the sol-gel method.The as-prepared samples were characterized by the X-ray diffraction and the upconversion luminescence spectra were recorded by a spectrophotometer.Under a 980 nm semiconductor laser excitation,green upconversion emissions of LiLa(MoO4)2:Yb3+,Er3+ at 530 nm and 550 nm can be observed,while the blue emission of LiLa(MoO4)2:Yb3+,Tm3+ at 475 nm can be seen by naked eye.Moreover,the upconversion mechanisms is discussed in our paper.the upconversion luminescences of Er3+ and Tm3+ are produced through a two-photon and a three-photon process,respectively.",
        "keywords": [
            "luminescence",
            "LiLa(MoO4)2",
            "upconversion material",
            "sol-gel method"
        ],
        "authors": [
            {
                "name": "LAN Yu-jing",
                "org": "College of Chemical and Enviromental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Enviromental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Journal of Beijing Technology and Business University(Natural Science Edition)",
        "year": 2010
    },
    "eK3xPkL6": {
        "id": "eK3xPkL6",
        "title": "Facile morphology-controlled synthesis and luminescence properties of BaMoO 4:Eu 3+ microparticles and micro-rods obtained by a molten-salt reaction route",
        "abstract": "This work focuses on the synthesis of morphology-controlled BaMoO 4:Eu 3+ micro-crystals such as microparticles and micro-rods using a facile molten salt method, and their morphology, structural characterization, and luminescent properties were comparatively investigated by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and fluorescence spectra. The molten salt method synthesized products from a reaction of BaMoO 4 precursor obtained by a co-precipitation method of BaCl 2 and Na 2MoO 4 with an eutectic salt mixture of NaCl-KCl at 700 °C. Detailed studies revealed that the formation of the different morphologies of the micro-crystals was strongly dependent on the weight ratio of the salt (NaCl-KCl) to the BaMoO 4 precursor, and the formation mechanism of the products in the present molten salt system was also investigated. Based on the investigations of the photoluminescence properties, the samples with different morphologies prepared by the molten salt method had the strongest red emission at 615 nm, corresponding to the Eu 3+ 5D 0? 7F 2 transition in the BaMoO 4 host lattice, and the emission intensity of BaMoO 4:Eu 3+ microparticles was stronger than that of BaMoO 4:Eu 3+ micro-rods. © 2011 American Scientific Publishers. All rights reserved.",
        "keywords": [
            "bamoo 4",
            "crystal growth",
            "luminescence",
            "molten salt synthesis"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Shuai Jin",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Peng Du",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Libing Liao",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Journal of Nanoscience and Nanotechnology",
        "year": 2011
    },
    "XucGZvXL": {
        "id": "XucGZvXL",
        "title": "Photoluminescence properties and energy transfer of Ce3+, Eu2+ co-doped Sr3Gd(PO4)3 phosphor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "junhui zeng",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2012
    },
    "exOdsS5t": {
        "id": "exOdsS5t",
        "title": "White upconverted luminescence of Ho3+/Yb3+/Tm 3+ tri-doped Gd2Mo3O9 phosphors",
        "abstract": "Yb3+/Tm3+/Ho3+ tri-doped Gd 2Mo3O9 phosphors were synthesized by the high-temperature solid-state method. Under 980 nm near-infrared excitation, the white-light emission can be observed, which is consists of the blue, green, and red UC emissions. The green and red emission at 547 nm and 660 nm originated from the transition of Ho3+ (5S2, 5F4 → 5I8 and 5F5 → 5I8) and the blue emission at 475 nm attributed to the transition of Tm3+ ( 5G4 → 5H6). In this experiment, we selected the optimum concentration ratio of the three rare earths for the bright white emission. The Commission internationale de L'Eclairage (CIE) coordinates for the samples were calculated, and chromaticity coordinates were very close to white light regions. We find that the calculated CIE color coordinates of the Yb3+/Tm3+/Ho3+ tri-doped Gd2Mo3O9 phosphors changed with the incident pump power from 400 mW/cm2 to 1000 mW/cm2. The upconversion luminescence mechanism of the samples was discussed on its spectral. The white light may be proved to be a candidate material for applications in various fields. © 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Gd2Mo3O9 phosphors",
            "Rare earths",
            "White-light emission"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Bing Xue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science and Engineering B: Solid-State Materials for Advanced Technology",
        "year": 2013
    },
    "tPuA5Jxs": {
        "id": "tPuA5Jxs",
        "title": "Luminescence Properties of Ba2Mg ( BO3 ) 2 : Eu2 + Red Phosphors Synthesized by a Microwave-Assisted Sol-Gel Route",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            },
            {
                "name": "jianfeng sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            }
        ],
        "venue": "Journal of The Electrochemical Society",
        "year": 2009
    },
    "h32DzLDT": {
        "id": "h32DzLDT",
        "title": "Visible-light responding BiVO4/TiO2 nanocomposite photocatalyst]",
        "abstract": "The two kinds of new nanocomposites BiVO4/TiO2 nanowires were synthesized by hydrothermal process. Their crystal structure, morphology and photocatalytic activities for degradation of methylene blue solution were characterized using various measurement techniques. The XRD results indicate that they are made up of monoclinic BiVO4 and anatase TiO2 phases. The SEM, TEM and HRTEM images show that the two samples include BiVO4 nanoparticles supported onto TiO2 nanowires. The UV-Vis absorption spectra reveal that the absorption edges of the samples exhibit red-shift in comparison with that of the pure TiO2 nanowires. The measurement results for the visible-light photodegradation of methylene blue show that the nanocomposite sample prepared from the layered titanate nanowires with Bi3+ has the highest photocatalytic activity.",
        "keywords": [
            "photocatalyst",
            "hydrothermal synthesis",
            "bivo4/tio2",
            "visible responding",
            "nanocomposite"
        ],
        "authors": [
            {
                "name": "Tian-hao Ji",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Fang Yang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiao-yan Zhou",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Hai-yan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jia-yue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2010
    },
    "kRNLL4XO": {
        "id": "kRNLL4XO",
        "title": "Study on luminescence properties of Eu2+ in (Sr, Ca)4Si3O8Cl4 host lattice]",
        "abstract": "Alkali earth chlorosilicate of the type Sr(4-x)Ca(x)Si3O8Cl4 was synthesized through the high temperature solid state method. According to the Van Uitert experimental equation, luminescence properties and crystal-lattice environment of Eu2+ in Sr(4-x) Ca(x)Si3O8Cl4 crystal were discussed. The possibilities of two Eu2+ emission centers, viz. blue and greenish-yellow centers, were found and their corresponding relationships with spectra were also discussed. When the doping amount of calcium(x) varied between 0 and 0.5, Ca2+ ions were embedded in the host lattice of Sr4Si3O8Cl4, and the luminescence of blue center, which was ascribed to the emission of Eu2+ that substituted the octa-coordination Sr2+ sites, dominated and showed blue-green luminescence. Sr(4-x)Ca(x)Si3O8Cl4:yEu2+ exhibited greenish-yellow luminescence when the range of x was between 0.5 and 2. This was due to the fact that the Eu2+ emission originated from the formation of an impurity-trapped exciton state. Greenish-yellow emission center was located in the impurity-trapped exciton state which was the lowest excited state of this system, and the Eu2+ emission was at long wavelengths, and a large Stokes shift was observed.",
        "keywords": [],
        "authors": [
            {
                "name": "Jia-yue Sun",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China."
            },
            {
                "name": "Zhi-guo Xia",
                "org": ""
            },
            {
                "name": "Hai-yan Du",
                "org": ""
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2005
    },
    "m1aKyC7I": {
        "id": "m1aKyC7I",
        "title": "Preparation and characterization of Ti 1 - x Zr x O 2/ZrO 2 nanocomposite",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Li Wang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Fang Yang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Tianhao Ji",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Qing-Lin Yang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Xingyi Qi",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, China"
            },
            {
                "name": "Jiayue Sun",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, China"
            }
        ],
        "venue": "Scripta Materialia",
        "year": 2008
    },
    "vlF3x5LH": {
        "id": "vlF3x5LH",
        "title": "Effect of trivalent rare earth ions doping on the fluorescence properties of electron trapping materials SrS: Eu2+",
        "abstract": "Trivalent rare-earth ions (La3+, Pr3+, Nd 3+, Sm3+, Gd3+, Tb3+, Dy 3+, Ho3+, Er3+, Tm3+, and Yb 3+) were investigated as the co- doped auxiliary sensitizer for the electron trapping materials SrS: Eu2+ in order to enhance the fluorescence properties. It was found that Sm3+ and Tb3+ had the best photoluminescence stimulated luminescence (PSL) effect among the selected trivalent rare-earth ions. All the SrS: Eu2+ samples doped by different trivalent rare-earth ions could be stimulated by 980 nm laser after being exposed to the conventional sunlight, and they emitted PSL with the peak located at 615 nm. The result also indicated that some co-doped rare earth ions could increase fluorescence intensities of the traditional electron trapping materials SrS: Eu2+. © 2011 The Chinese Society of Rare Earths.",
        "keywords": [
            "electron trapping effect",
            "optical storage materials",
            "photo-stimulated luminescence",
            "rare earths"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhenxing Liu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2011
    },
    "B5afysFA": {
        "id": "B5afysFA",
        "title": "Study on Preparation and Properties of Fluorescent Offset Printing Ink",
        "abstract": "The ultraviolet (UV) fluorescent anti-counterfeiting offset printing ink, which can emit visible light (400-800 nm) under the excitation of ultraviolet light (200-400 nm), has been extensively adopted in the modern printing technology. In this paper, we used the red-emitting phosphor BaCaBO3F: Eu3+, Li+ as the fluorescent pigment for printing ink and investigated the influence on additive amount of the luminescence properties of fluorescent ink in order to determine a more ideal ratio of fluorescent ink .Besides, the shear viscosity, thixotropy, visco-elasticity and the temperature dependence of viscosity according to the rheology theory and rheological technique were also studied, and finally the valuable parameters and patterns were successfully obtained.",
        "keywords": [
            "UV fluorescent ink",
            "Anti-counterfeiting printing",
            "Luminescence properties",
            "Printing adaptabilities"
        ],
        "authors": [
            {
                "name": "XU Wencai",
                "org": "Beijing Key Laboratory of Printing and Packaging Materials and Technology,Beijing Institute of Graphic Communication,Beijing ,China"
            },
            {
                "name": "SUN Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "LUO Shiyong",
                "org": "Beijing Key Laboratory of Printing and Packaging Materials and Technology,Beijing Institute of Graphic Communication,Beijing ,China"
            }
        ],
        "venue": "PRINTING AND PACKAGING STUDY",
        "year": 2010
    },
    "kwgXkDIc": {
        "id": "kwgXkDIc",
        "title": "Luminescent properties and energy transfer of double-emitting NaSrPO 4:Eu 2,Tb 3 phosphor for near-UV white LEDs",
        "abstract": "Novel blue/green NaSrPO 4 phosphors co-doped with Eu 2 and Tb 3 were synthesized by a conventional solid-state reaction. Their luminescent properties were characterized by using powder X-ray diffraction, photoluminescence excitation and emission spectra, lifetime, and temperature dependent emission spectra, respectively. The NaSrPO 4:Eu 2,Tb 3,Na phosphor showed an intense broad excitation band between 250 and 430 nm, which was in agreement with the near-UV chip (350-420 nm), and it exhibited two dominating emission bands at 445 and 545 nm, corresponding to the allowed 4f 65d 1→4f 7( 8S 7/2) transition of Eu 2 ion and the 5D 4→ 7F 5 transition of Tb 3 ion, respectively. The emission intensity and lifetime of Eu 2 ion decreased with the increasing concentration of Tb 3 ion, which strongly indicated that an effective energy transfer occurred from Eu 2 to Tb 3 in NaSrPO 4 host. The principle of the energy transfer should be the combined effect of the non-radiative resonant energy transfer and the phonon-assisted non-radiative process. © 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "energy transfer",
            "luminescence",
            "optical materials",
            "white leds"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2012
    },
    "YcSIoOVC": {
        "id": "YcSIoOVC",
        "title": "Luminescence properties and energy transfer investigations of Sr2B2O5:Ce3+,Tb3+ phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "jinli lai",
                "org": ""
            },
            {
                "name": "jicheng zhu",
                "org": ""
            },
            {
                "name": "zhiguo xia",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2012
    },
    "ioMIhelb": {
        "id": "ioMIhelb",
        "title": "Comparative study on luminescent properties of NaYF_4:Tm~(3+),Yb~(3+) with three precipitator",
        "abstract": "The NaYF4∶Tm3+,Yb3+ materials were prepared by co-precipitation method with EDTA,citric acid and H2C2O4,respectively.The effects of complexing agents,precipitation temperature and combustion temperature were investigated on the luminescent properties,particle size and morphology by X-ray diffraction,SEM and fluorescence spectrum.The results showed that the best luminescence material NaYF4∶Tm3+,Yb3+ can be obtained by selecting H2C2O4 as precipitator.The siring at 600℃ for 5h.",
        "keywords": [
            "luminescent property",
            "co-precipitation",
            "rare earths"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "YANG Zhi-ping",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Journal of Functional Materials",
        "year": 2009
    },
    "EwbGHwHB": {
        "id": "EwbGHwHB",
        "title": "Study on synthesis,crystal structure and anti-copying application of 6,8-bibromo-spiro(2H-1-benzopyran2,2'-indoline) compound",
        "abstract": "A compound of 6,8-dibromo-1',3',3'-trimethylspiro[2H-1-benzopyran-2,2'-indoline]was designed and synthesized.The structure of the compound was characterized by 1H-NMR,IR,elemental analysis and melting point.The single crystals of compound was obtained by slow evaporation at room temperature and determined by X-ray diffractometer.Its crystals belonged to the tetragonal system with a space group of P4(1) and the following cell parameter:a=8.2226(3),b=8.2226(3),c=26.995(2),α=β=γ=90°,V=1825.18(17) 3,Dc=1.584mg/m3,μ=4.445mm-1,F(000)=864,Z=4,R1=0.1575,wR2=0.2520.This section carried on a systemic study on application of indolinespiropyran in coating system.It determined a better formulation of coating,which was transferred to paper through coating and formed an organic membrane structure of anti-copying paper.The anti-copying mechanism of the coated paper were characterized by reflectance spectroscopy.",
        "keywords": [
            "reflectance spectrum",
            "indolinespiropyran",
            "crystal structure",
            "anti-copying film"
        ],
        "authors": [
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Ji Yidong",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2010
    },
    "T4PfNjtn": {
        "id": "T4PfNjtn",
        "title": "Wet-chemical processing and angle-dependent optical properties characterization of mica/TiO2/Al2O3/M 2O3 (M = Fe, Cr, Co) pigments",
        "abstract": "The four-layer structure angle-dependent pigments with compositions of Mica/TiO2 /Al2O3/Fe2O3, Mica/TiO2/Al2O3/Cr2O3 and Mica/TiO2/Al2O3/Co2O3 were firstly prepared by the wet-chemical coating method, respectively. The as-prepared pigments were performed by precipitating different metal ions, such as Cr3+, Fe3+, Co2+ and Al3+, on the pretreated substrates, mica titanium. The optical effects of four-layer structure pigments were investigated in detail by using the five angles' spectrophotometer. The angle-dependent spectral reflectance and color changes can be quantitatively measured, and the results show that the angle-dependent effects for the as-prepared pigment were improved by the increasing coated Al2O3 layers. © (2011) Trans Tech Publications.",
        "keywords": [
            "Angle-dependent optical properties",
            "Coating",
            "Mica titanium",
            "Pigments"
        ],
        "authors": [
            {
                "name": "hai yan du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "cai xia liu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "jia yue sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "s231zlUo": {
        "id": "s231zlUo",
        "title": "Preparation of Non-Grinding Long Afterglow SrAl_2O_4:Eu~(2+), Dy~(3+) Material by Microwave Combustion Method",
        "abstract": "The non-grinding long afterglow material SrAl2O4∶Eu2+, Dy3+ was prepared by combustion method in home microwave oven directly, after dispersant, frother, comburent, and mineralizer were added into the reacting system. XRD analysis showed that the powders were nearly pure SrAl2O4 phase with few other phases, and the size of the grain was 41.1 nm. Fluorescence spectrum results indicated that there were 2 excitation peaks located at 345 and 400 nm, and the emission peak located at 516 nm, afterglow lasted up to 30 min or more. The microwave combustion method has advantages of less time, low temperature and no grinding process, and the material made by the method has good luminescent property.",
        "keywords": [
            "microwave combustion",
            "non-grinding",
            "Dy3+",
            "SrAl2O4∶Eu2+",
            "long afterglow",
            "rare earths"
        ],
        "authors": [
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "Li Gengshen",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2007
    },
    "yfxnmXki": {
        "id": "yfxnmXki",
        "title": "Near-infrared luminescence and quantum cutting mechanism in CaWO4:Nd3+, Yb3+",
        "abstract": "An efficient near-infrared (NIR) quantum cutting (QC) by converting ultraviolet into NIR via cooperative downconversion (DC) for the (Nd, Yb) couple in CaWO is studied since efficient two-step energy transfer occurs from the G level of Nd to two neighboring Yb:F level. The authors have analyzed the measured luminescence spectra and decay lifetimes for different Yb concentrations and proposed a mechanism to rationalize the DC effect. The maximum quantum efficiency (QE) of Nd is up to 164.03 %. Application of the broadband NIR-QC phosphors might enhance the performance of silicon-based solar cells.",
        "keywords": [
            "Solar Cell",
            "Quantum Efficiency",
            "Concentration Quenching",
            "Energy Transfer Efficiency",
            "CaWO4"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "yining sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "chun cao",
                "org": "beijing technology and business university"
            },
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            }
        ],
        "venue": "Applied Physics B",
        "year": 2013
    },
    "j2FD8u3X": {
        "id": "j2FD8u3X",
        "title": "Near-infrared downconversion in Eu~(2+) and Pr~(3+) co-doped KSrPO_4 phosphor",
        "abstract": "A novel near-infrared (NIR) downconversion (DC) phosphor KSrPO4 :Eu2+ , Pr3+ is synthesized by the conventional high temperature solid-state reaction. The Eu2+ acts as an efficient sensitizer for Pr3+ in the KSrPO4 host. With broad-band near-ultraviolet light excitation induced by the 4f→5d transition of Eu2+ , the characteristic NIR emission of Pr3+ , peaking at 974 nm and 1019 nm due to 3P0 → 1G4 and 1G4 → 3H4 transitions, is generated as a result of the energy transfer from Eu2+ to Pr3+ . The luminescence spectra in both the visible and the NIR regions and the decay lifetime curves of Eu2+ prove the energy transfer from Eu2+ to Pr3+ . This Eu2+ and Pr3+ co-doped KSrPO4 phosphor may be a promising candidate to modify the spectral mismatch behavior of crystalline solar cells and sunlight.",
        "keywords": [
            "downconversion",
            "optical properties",
            "cooperative energy transfer"
        ],
        "authors": [
            {
                "name": "Sun Jia-Yue",
                "org": " School of Science, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "Sun Yi-Ning",
                "org": " School of Science, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "Zhu Ji-Cheng",
                "org": " School of Science, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "Zeng Jun-Hui",
                "org": " School of Science, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "Du Hai-Yan",
                "org": " School of Science, Beijing Technology and Business University, Beijing , China"
            }
        ],
        "venue": "中国物理B",
        "year": 2013
    },
    "L4oXcCdK": {
        "id": "L4oXcCdK",
        "title": "Downconversion for solar cells in Sr 3Gd(PO 4) 3:Tb, Yb phosphors",
        "abstract": "An efficient near-infrared (NIR) quantum cutting (QC) Tb3+ and Yb3+ co-doped phosphor Sr3Gd(PO4)(3) has been synthesized by conventional high temperature solid technique. Upon excitation of Tb3+ with a visible photon at 485 nm, two NIR photons could be emitted by Yb3+ through cooperative energy transfer (CTE) from Tb3+ to two Yb3+ ions. Excitation and emission spectra as well as fluorescence decay measurements have been carried out to examine the occurrence of cooperative energy transfer (CET) from Tb3+ to Yb3+ ions. The result indicates Tb3+ and Yb3+ co-doped Sr3Gd(PO4)(3) is potentially used as down-converter layer in silicon-based solar cells.",
        "keywords": [
            "downconvertion",
            "quantum cutting",
            "cooperation energy transition"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "PROGRESS IN NEW MATERIALS AND MECHANICS RESEARCH",
        "year": 2012
    },
    "l37agixw": {
        "id": "l37agixw",
        "title": "Preparation and visible-light photocatalysis of MS(M=Cd or Zn) nanoparticle-supported TiO_2 nanowires",
        "abstract": "High-temperature-stable hexagonal CdS or low-temperature-stable cube ZnS nanoparticles supported anatase TiO2 nanowires were prepared using the precursors layered titanate nanowires,CdCl2 or ZnSO4 and thioacetamide by two-step hydrothermal synthesis process.Titanate nanowires with Cd2+ or Zn2+ cations were first obtained using layered titanate nanowires and CdCl2 or ZnSO4 under the hydrothermal condition;then,the products were treated in the diluted thioacetamide solution at 160℃ to prepare CdS-or ZnS-supported TiO2 nanowires.After they were immersed into diluted HCl solution,the CdS or ZnS nanoparticles on TiO2 nanowires could still be observed.The visible-light photocatalytic measurement results for the acid-treated samples,pure TiO2 nanowires and commercial P25 demonstrate that the photocatalysis of TiO2 nanowires with CdS is the highest.",
        "keywords": [
            "TiO2 nanowires",
            "CdS nanoparticles",
            "ZnS nanoparticles",
            "hydrothermal synthesis",
            "composite nanowires"
        ],
        "authors": [
            {
                "name": "JI Tian-hao",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "TIAN Miao",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "GE Guang-lu",
                "org": "National Center for Nanoscience and Technology,Beijing ,China"
            }
        ],
        "venue": "Journal of Functional Materials",
        "year": 2010
    },
    "BxFyysEJ": {
        "id": "BxFyysEJ",
        "title": "Study on luminescence properties and crystal-lattice environment of Eu2+ in Sr4-xMgxSi3 O8Cl4: Eu2+ Phosphor",
        "abstract": "According to the Van Uitert experimental equation, crystal-lattice environment of Eu2+ in the Sr4-xMgx Si3O8Cl4 crystal was discussed. By adding Mg2+ to the host lattice, Sr4-x Mgx Si3O8Cl4: Eu2+ was synthesized and the emission peak shifted from blue-green (488 nm) to blue-violet (411 nm) with the increase of amount of the magnesium which replaced the strontium. By analyzing the spectra of Sr4-xMgxSi3 O8Cl4: Eu2+ the two Eu2+ emission centers were found because of the change of crystal -lattice environment in the host and the crystal structure was obtained by X-ray diffraction data.",
        "keywords": [
            "Chlorosilicate",
            "Crystal-lattice environment",
            "Luminescence",
            "Rare earths",
            "Spectra"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2004
    },
    "KZhJ73af": {
        "id": "KZhJ73af",
        "title": "Synthesis and Analysis of Novel Solid State Lighting Compound Ca_3SiO_4Br_2∶Eu~(2+)",
        "abstract": "Novel blue-emitting material,Eu2+-doped Ca3SiO4Br2 was reported in this paper.Flaky crystals of Ca3SiO4Br2 were grown out of high-temperature Ca2SiO4/CaBr2 melts.The crystal structure was determined as the chemical composition of Ca3SiO4Br2,and structural investigations have also shown that Ca3SiO4Br2 is composed of the layers of calcium chloride and dicalcium silicate.Based on the photoluminescence analysis,Ca3SiO4Br2∶Eu2+ phosphor exhibited a broad blue emission band of main peak at 470 nm under the near ultraviolet(n-UV) light(300～450 nm),and efficient n-UV absorption property can be testified by UV-Vis diffuse reflectance spectra.It indicated that halosilicate materials Ca3SiO4Br2∶Eu2+ phosphor is an excellent phosphor in the application of the white LEDs.",
        "keywords": [
            "rare earth luminescence",
            "blue emission phosphor",
            "halosilicate",
            "white light LED lighting",
            "crystal structure"
        ],
        "authors": [
            {
                "name": "XIA Zhi-guo",
                "org": "School of Materials Sciences and Technology,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "LI Guo-wu",
                "org": "School of Materials Sciences and Technology,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "XIONG Ming",
                "org": "School of Materials Sciences and Technology,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Luminescence",
        "year": 2011
    },
    "bTc1N4K0": {
        "id": "bTc1N4K0",
        "title": "Applications of organic photochromic materials in anti-counterfeiting technology",
        "abstract": "A functional chemical materials—organic photochromic materials were outlined.It could change color through the opening ring-the closed ring,structure isomerous and redox process,ect.,in different wavelengths of light irradiation.Some of its anti-counterfeiting applications were introduced.The proposals of increase anti-counterfeiting effects were put forward.Applying organic photochromic materials to develop new anti-counterfeiting materials is worthy to be emphasized and enhanced in the relevant investigations.",
        "keywords": [
            "anti-counterfeiting paper",
            "anti-counterfeiting printing ink",
            "photochromism"
        ],
        "authors": [
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technologyand Business University,Beijing "
            },
            {
                "name": "Ji Yidong",
                "org": "College of Chemical and Environmental Engineering,Beijing Technologyand Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technologyand Business University,Beijing "
            },
            {
                "name": "Zhou Wei",
                "org": "College of Chemical and Environmental Engineering,Beijing Technologyand Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2009
    },
    "ZRnAQbKV": {
        "id": "ZRnAQbKV",
        "title": "Near-infrared quantum cutting in Eu 2+ , Yb 3+ co-doped Sr 3 Gd(PO 4 ) 3 phosphor",
        "abstract": "",
        "keywords": [
            "lanthanides"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "junhui zeng",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Optical Materials",
        "year": 2013
    },
    "Z3KxmvRj": {
        "id": "Z3KxmvRj",
        "title": "The hydrothermal synthesis method of abio-nanoparticles and it's extending method",
        "abstract": "The preparation of abio-nanoparticles by the hydrothermal synthesis methods was summarized,discussed the advantages and disadvantages of these methods,the mechanism and the situation of the water in the chemical process were superficially analyzed too;also analyzed the extending method-solvothermal synthesis and microwave-hydrothermal synthesis methods,introduced the solvents usually be used in these methods and the heating mechanism in the microwave-hydrothermal synthesis;pointed out nowadays the proceeding and the applying of these methods.",
        "keywords": [
            "solvothermal synthesis",
            "microwave-hydrothermal",
            "hydrothermal synthesis",
            "synthesis method"
        ],
        "authors": [
            {
                "name": "He Ciquan",
                "org": "Beijing Technology and Business University College of Chemical and Enviromental Engineering Applied Chemistry,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "Beijing Technology and Business University College of Chemical and Enviromental Engineering Applied Chemistry,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "Beijing Technology and Business University College of Chemical and Enviromental Engineering Applied Chemistry,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2007
    },
    "xuougboW": {
        "id": "xuougboW",
        "title": "Synthesis and study on its luminescence properties of (CaO-CaCl2-SiO2):Eu2+",
        "abstract": "Eu2+-doped alkali earth chlorosilicate phosphor of the types (CaO-CaCl2-SiO2):Eu2+ was synthesized through the high temperature solid state method. Its structure and luminescence properties were investigated by using X-ray diffraction (XRD), excitation and emission spectra. Under the excitation of the near-ultraviolet (UV) light (350-420nm), the (CaO-CaCl2-SiO2):Eu2+ phosphor synthesized at 900°C emits an intense green light peaking at 510nm, whereas the same component phosphor synthesized at 1100°C emits an yellow light peaking at 582nm. In addition, luminescence properties and crystal-lattice environment of Eu2+ in (CaO-CaCl2-SiO2) crystal synthesized at 1100°C were discussed according to the Van Uitert experimental equation and the possibilities of two Eu2+ emission centers, viz, green and yellow centers were confirmed. The mechanisms of concentration quenching in (CaO-CaCl2-SiO2):Eu2+ phosphor were also discussed, which were caused by the energy transfer among the nearest-neighbor ions in this phosphor system.",
        "keywords": [
            "Concentration quenching",
            "Luminescence",
            "WLEDs"
        ],
        "authors": [
            {
                "name": "Jianfeng Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2010
    },
    "1j5Cu2Wp": {
        "id": "1j5Cu2Wp",
        "title": "Upconversion luminescence of Yb3+/Ho3+/Er 3+/Tm3+ co-doped KGd(WO4)2 powders",
        "abstract": "Different lanthanide ions (Yb3+/Ho3+/Er 3+/Tm3+) codoped KGd(WO4)2 phosphors were prepared by high-temperature solid-state reaction. The upconversion luminescence properties of two-ion and three-ion co-doped KGd(WO 4)2 phosphors were investigated in detail. The concentration quenching effect of the two-ion co-doped KGd(WO4) 2 phosphors was studied, and the optimum concentration of Ho 3+, Er3+ and Tm3+ are 2 mol., 2 mol. and 3 mol., respectively. The Yb3+/Ho3+/Tm3+ co-doped KGd(WO4)2 sample is the best white upconversion luminescence material among three-ion co-doped KGd(WO4)2 phosphors. The CIE coordinates for the samples were calculated, and chromaticity coordinates were close to white light regions. The upconversion luminescence mechanism of the samples was discussed. The upconversion luminescence of Ho 3+ and Er3+ was both produced through two-photon process. The emissions of Ho3+ at 546 and 654 nm originated from the transition of Ho3+ (5S2→5I 8 and 5F5→5I8), while those of Er3+ at 530 and 551 nm were attributed to the transition of Er3+ (2I11/2→ 4I15/2 and 4S3/2→ 4I15/2). The upconversion luminescence mechanism of Tm3+ was a three-photon process. The blue emission of Tm3+ was due to the transition of Tm3+ (1G4→ 3H6). © 2010 The Chinese Society of Rare Earths.",
        "keywords": [
            "KGd(WO4)2 powder",
            "rare earths",
            "upconversion luminescence",
            "white light phosphor"
        ],
        "authors": [
            {
                "name": "d u haiyan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Yujing Lan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2010
    },
    "42f0siVj": {
        "id": "42f0siVj",
        "title": "Preparation and Characterization of Room-temperature Ferromagnetic Ni-doped TiO_2 Nanobelts",
        "abstract": "Ni-doped anatase TiO2 nanobelts (NBs) with different Ni2+ contents were simply prepared by combining ion-exchange with hydrothermal treatment. They were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), and magnetic measurement techniques. The results showed that Ni2+ cations doped into the TiO2 lattice and no metallic nickel clusters or nanoparticles could be found. The magnetic results demonstrated that the prepared Ni-doped TiO2 samples had complex magnetic mechanism including room-temperature ferromagnetic and paramagnetic behaviors, and with the increase of Ni2+ content, the magnetization also increased under the same applied field owing to uniform distribution of Ni2+ ions in TiO2 nanobelts.",
        "keywords": [
            "ni-doped tio2",
            "room-temperature ferromagnetic",
            "diluted magnetic semiconductor",
            "nanobelts",
            "ion exchange",
            "transmission electron microscopy",
            "scanning electron microscopy",
            "nickel",
            "high resolution transmission electron microscopy",
            "room temperature",
            "x ray photoelectron spectroscopy",
            "uniform distribution"
        ],
        "authors": [
            {
                "name": "ZHANG Hong-Ye",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing , P. R. China"
            },
            {
                "name": "JI Tian-Hao",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing , P. R. China"
            },
            {
                "name": "LI Ling-Long",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing , P. R. China"
            },
            {
                "name": "QI Xing-Yi",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing , P. R. China"
            },
            {
                "name": "LIU Yi-Fan",
                "org": "State Key Laboratory of Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing , P. R. China"
            },
            {
                "name": "CAI Jian-Wang",
                "org": "State Key Laboratory of Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing , P. R. China"
            },
            {
                "name": "DU Hai-Yan",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing , P. R. China"
            },
            {
                "name": "SUN Jia-Yue",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing , P. R. China"
            }
        ],
        "venue": "Acta Physico-Chimica Sinica",
        "year": 2008
    },
    "lB6L6RQF": {
        "id": "lB6L6RQF",
        "title": "Influence of systematic environment on chemiluminescence efficiency",
        "abstract": "The character,composition of chemical light as well as its luminescent mechanism were introduced.Some factors affecting its chemiluminescence efficiency were specified.The related research development was generally outlined.",
        "keywords": [
            "chemiluminescence",
            "systematic environment",
            "light efficiency",
            "chemical light"
        ],
        "authors": [
            {
                "name": "Du Haiyan",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing"
            },
            {
                "name": "Xue Yanju",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing"
            },
            {
                "name": "Sun Jiayue",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing"
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2009
    },
    "aWrXWjg8": {
        "id": "aWrXWjg8",
        "title": "Synthesis and luminescence properties of novel LiSrPO{sub 4}:Dy{sup 3+} phosphor",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xiangyan Zhang",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2011
    },
    "Sterwqh1": {
        "id": "Sterwqh1",
        "title": "Facile synthesis of well-dispersed SrF2:Yb3+/Er 3+ upconversion nanocrystals in oleate complex systems",
        "abstract": "Well oil-dispersible SrF2:Yb3+/Er3+ upconversion (UC) nanocrystals (NCs) were easily synthesized in the water-ethanol-oleic acid-sodium oleate complex systems. The as-prepared NCs all show size-uniformity, and their sizes, morphologies can be controlled by varying the solvent and reaction time, and rectangular SrF2:Yb 3+/Er3+ nanosheets with the sizes of 5-25 nm can be obtained. The possible mechanism on the nucleation and growth of nanocrystals occurred at the oleic acid/sodium oleate interface was also discussed. The size and morphology dependent UC luminescence behaviors have been observed in SrF2:Yb3+/Er3+ NCs, and their UC luminescence transitions were proposed. The as-prepared UC nanocrystals are expected to fulfill the demand for biological applications. © 2010 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Morphology",
            "Nanomaterials",
            "Optical properties",
            "Upconversion"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianbo B. Xian",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2011
    },
    "uUxBD9pD": {
        "id": "uUxBD9pD",
        "title": "An investigation of angle-dependent optical properties of multi-layer structure pigments formed by metal-oxide-coated mica",
        "abstract": "The chromaticity coordinates show the color travel effect of mica/TiO 2 /Cr 2 O 3 /Fe 2 O 3 , mica/TiO 2 /SiO 2 /Fe 2 O 3 and mica/TiO 2 /SiO 2 /Co 2 O 3 four-layer structure system and mica/TiO 2 /Cr 2 O 3 , mica/TiO 2 /Fe 2 O 3 and mica/TiO 2 /Co 2 O 3 three-layer structure system. The comparative angle-dependent optical effect of three-layer and four-layer system pigments based on different metal-oxide-coatings indicates the enhanced optical properties by the increasing coated layers.",
        "keywords": [
            "wet chemical method",
            "optical properties",
            "mica titanium",
            "angle-dependent pigments",
            "titanium"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, PR China"
            },
            {
                "name": "Caixia Liu",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, PR China"
            },
            {
                "name": "Jiayue Sun",
                "org": ""
            },
            {
                "name": "Qirong Chen",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, PR China"
            }
        ],
        "venue": "Powder Technology",
        "year": 2008
    },
    "UUwuVvIG": {
        "id": "UUwuVvIG",
        "title": "Research progress of preparation methods and application of MF_2 type rare-earth fluorescent nanomaterials",
        "abstract": "MF2 type(M=Mg,Ca,Sr,Ba) fluorescent nanomaterials have unique electronic,optical and chemical properties,which have been widely used in luminescence devices,displays,optical imaging and biolabeling and so on.A comprehensive review was presented on the general preparation methods of MF2 fluorescent nanomaterials.The application and the development trends of the MF2 fluorescent nanomaterials were also proposed.",
        "keywords": [
            "preparation",
            "alkaline earth fluoride",
            "nanomaterial"
        ],
        "authors": [
            {
                "name": "Xian Jianbo",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Zhang Xiangyan",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "School of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2011
    },
    "qcpW0QKV": {
        "id": "qcpW0QKV",
        "title": "Improved moisture resistance of SrSO 4:Sm 3+ phosphors coated with SiO 2",
        "abstract": "SrSO 4:Sm 3+ phosphors obtained by precipitation method are coated with SiO 2 and their photoluminescence (PL) degradation behavior is investigated. The SiO 2 coating is obtained by the ultrasonic sonochemical process using tetraethylorthosilicate (TEOS) as silicon coating reagent and the coating content is varied from 0.5 to 2 wt%. Powder X-ray diffraction (XRD) patterns, scanning electron microscopy (SEM), fluorescence spectrometer, and Fourier transform infrared spectrometer are employed to characterize the coating. Moisture resistances of coated SrSO 4:Sm 3+ phosphors have been enhanced to a great degree without more loss of their optical properties based on the existence of the SiO 2 thin layer. The PL intensity of the coated phosphors decreases to ∼83% of the original value after 38 h soaking the phosphors in deionized water, while the uncoated phosphor decreases to ∼40%. © 2011 Elsevier B.V. All rights reserved.",
        "keywords": [
            "phosphors",
            "srso 4:sm 3+",
            "surfaces"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Randi Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2012
    },
    "BXDCa65w": {
        "id": "BXDCa65w",
        "title": "Preparation and characterization of Ti1 - xZrxO2/ZrO2 nanocomposite",
        "abstract": "Hierarchical Ti1 - xZrxO2/ZrO2 nanocomposite was prepared by a hydrothermal method through a combination of the sol-gel process and co-precipitation from tetrabutyl titanate and ZrOCl2. Structures and properties were characterized by various measurement techniques. It was demonstrated that the products with a radial shape and a large specific surface area had superhydrophilicity and high photocatalytic activity. X-ray diffraction and energy-dispersive X-ray measurement analysis indicated that the Zr4+ ions were incorporated into the anatase TiO2 lattice. © 2008 Acta Materialia Inc.",
        "keywords": [
            "Doping",
            "Hydrothermal method",
            "Nanocomposite",
            "Titania",
            "Zirconia"
        ],
        "authors": [
            {
                "name": "Li Wang",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Fang Yang",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Tianhao Ji",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Qinglin Yang",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Xingyi Qi",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Scripta Materialia",
        "year": 2008
    },
    "iZySgmkc": {
        "id": "iZySgmkc",
        "title": "Synthesis, structure and luminescence properties of Y(V,P)O 4:Eu3+,Bi3+ phosphors",
        "abstract": "YVO4:Eu3+-based red-emitting phosphors with the compositions of Y0.95-xVO4:0.05Eu3+,xBi 3+ (x=0.01, 0.03, 0.05, 0.07 and 0.09) and Y0.90(V 1-zPz)O4:0.05Eu3+,0.05Bi 3+ (z=0, 0.1, 0.3, 0.5, 0.7, 0.9 and 1.0) were synthesized by the high temperature solid-state method. The as-prepared phosphors have the similar tetragonal phase structure and their morphologies varied with the relative content ratio of V to P. The photoluminescence spectra for the as-synthesized phosphors show that a dominant red emission line at around 619 nm, which is due to the Eu3+ electric dipole transition of 5D 0-7F2, is observed under different excitation wavelengths (254 and 365 nm). Further, the emission intensities of 5D0-7F2 transition upon 365 nm excitation increase sharply owing to the Bi3+ doping. Energy transfer process, luminescent lifetime and quantum efficiency for the selected Y 0.90(V1-yPy)O4:0.05Eu 3+,xBi3+phosphors were also studied in detail. © 2010 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Energy transfer",
            "Phosphatevanadates",
            "Photoluminescence",
            "Red-emitting phosphors"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianbo B. Xian",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2010
    },
    "FM8vr63H": {
        "id": "FM8vr63H",
        "title": "Template-free hydrothermal synthesis of SrSO 4:Sm 3+ microrods and its electron trapping luminescence properties",
        "abstract": "A hydrothermal process without using any surfactants or templates has been employed to prepare SrSO 4 microrods with different crystallographic morphologies. The pH value of the reaction solution is determined to be the key factor in the formation of rod-like morphology. It is found that the length-to-diameter ratio (L/D) of the rod-like SrSO 4 crystals increases from 1 to 4 when the pH value increases from 3 to 12. Besides, the effects of hydrothermal reaction time and temperature have been investigated to illustrate the morphological evolution process of SrSO 4 crystals, and it is also discussed that the microcrystals formation mechanism of the evolution process. © 2011 Elsevier B.V. All rights reserved.",
        "keywords": [
            "chemical synthesis",
            "crystal growth",
            "microstructure",
            "optical properties"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Randi Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2012
    },
    "oG39ZFHS": {
        "id": "oG39ZFHS",
        "title": "Synthesis and spectral analysis of Yb3+/Tm3+/Ho 3+-doped Na0.5Gd0.5WO4 phosphor to achieve white upconversion luminescence",
        "abstract": "Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 phosphors were synthesized by the high-temperature solid-state method. Bright white luminescence upon 980 nm near-infrared excitation can be observed for the sample at the optimum chemical composition of Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ /0.4%Ho 3+ , which is produced via an upconversion (UC) process by tuning the dopant ions concentration. The measured white light consists of the blue, green, and red UC emissions which correspond to the transitions 1 G 4 → 3 H 6 of Tm 3+ , 5 F 4 ( 5 S 2 ) → 5 I 8 , and 5 F 5 → 5 I 8 of Ho 3+ ions, respectively. The calculated color coordinates display that white light can be achieved in a wide range of dopant concentrations. The UC mechanisms were also proposed based on their spectral and pumping power dependence analyses. Keywords A. Optical materials C. X-ray diffraction D. Optical properties 1 Introduction Lanthanide (Ln 3+ )-doped luminescence materials are particularly attractive in both the academic and industrial fields due to their unique optical properties arising from the intra-4 f transitions [1] . Recently, a growing interest has been focused on white light-emitting diodes (w-LEDs), especially phosphor-converted w-LEDs, because of their high luminous efficiency, long lifetimes, low environmental impact, and small structure type [2,3] . Therefore, many Ln 3+ -doped luminescence materials based on the blue and near ultraviolet (NUV) light excitation have been developed in order to obtain white light emission [4,5] . Since photon upconversion (UC) can also be used for the generation of visible emission by near-infrared (NIR) excitation of Ln 3+ -doped materials, one technical problem in UC materials is the exploration of those phosphors that can be excited with commercially available NIR diode lasers and exhibit white upconversion luminescence, which also should possess a degree of brightness comparable to those excited conventionally using NUV light, and this strategy has been proved to be very promising [6–8] . Some efforts have been made to develop white light emission Ln 3+ -doped materials via UC process, for example, Sivakumar et al. [9] reported the white UC luminescence SiO 2 , ZrO 2 sol–gel thin film made with Ln 3+ (Tm 3+ , Er 3+ , Eu 3+ )-doped LaF 3 nanoparticles codoped with Yb 3+ ions. After that, single-phase rare earth oxide matrices, such as Y 2 O 3 [10] , Lu 2 O 3 [11] , Lu 3 Ga 5 O 12 [12] , Gd 2 (MoO 4 ) 3 [13] and La 2 (MoO 4 ) 3 [14] have also been reported as white UC luminescence host, which is related to the combination of upconverted blue (from Tm 3+ ), green, and red (from Er 3+ ) emissions to produce the white luminescence. Despite these reports, there is a continuous demand for new and efficient white light UC materials in advanced technological applications. It is well-known that the rare earth tungstate and molybdate matrix are highly chemically, photothermally, and photochemically stable and have a broad optical transparence from the visible to the NIR regions [15] . In this paper, we report the synthesis of Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 UC luminescence materials prepared by the high-temperature solid-state method. Compared with the conventional Yb 3+ /Tm 3+ /Er 3+ combination as the white UC emission ions [10–12] , this is another novel result on Yb 3+ /Tm 3+ /Ho 3+ combination as the white UC emitter. Their white UC luminescence properties and mechanisms are also investigated in this paper. 2 Experimental The powder samples of Yb 3+ /Tm 3+ , Yb 3+ /Ho 3+ , and Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 materials were prepared by the traditional high-temperature solid-state reaction. The starting materials were Na 2 CO 3 (A.R.), 5(NH 4 ) 2 O·12WO 3 ·5H 2 O (A.R.), Gd 2 O 3 (99.99%), Yb 2 O 3 (99.99%), Tm 2 O 3 (99.99%) and Ho 2 O 3 (99.99%). For the typical synthesis of 10%Yb 3+ /1%Tm 3+ /0.4%Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 powders, the calculated starting compositions are as follows: 0.25 Na 2 CO 3 + 1/12 5(NH 4 ) 2 O·12WO 3 ·5H 2 O + 0.193 Gd 2 O 3 + 0.05 Yb 2 O 3 + 0.005 Tm 2 O 3 + 0.002 Ho 2 O 3 . The weighed raw materials were thoroughly mixed in an agate mortar and then placed in an alumina crucible with a lid. Then, the samples were sintered for 4 h at the selected temperature, 600 °C, 700 °C and 800 °C. The phase structure of the as-synthesized Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 materials was determined by X-ray powder diffraction spectroscopy (XRD, Shimadzu XRD-6000) operating at Cu Kα radiation, 40 kV, 30 mA, and a scan speed of 2.0° (2 θ )/min. Microstructure evolution was observed using a scanning electron microscopy (SEM) (JEOL, JSM-6490). The UC luminescence spectra were recorded on a Hitachi F-4500 spectrophotometer equipped with an external power-controllable 980 nm semiconductor laser (Beijing Viasho Technology Company, China) as the excitation source, which is connected with an optic fiber accessory. The CIE chromaticity coordinates of this work were calculated by the UC spectra based on the 1931 CIE standard. 3 Results and discussion Fig. 1 a shows the XRD patterns of Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 sample prepared at different temperatures, 600 °C, 700 °C, and 800 °C. It is found that the XRD patterns of the samples with different synthesis temperatures are very similar, only several low impurity diffraction peaks around 24° can be found when the synthesis temperature is below 800 °C. Therefore, the optimum synthesis temperature for Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 sample can be fixed as 800 °C in our experiment. It is also found from Fig. 1 a that the peak positions agree well with those of the standard pattern (JCPDS no. 25-0829) for Na 0.5 Gd 0.5 WO 4 in scheelite structure, which has tetragonal symmetry (space group I 4 1 / a ) with the lattice constants of a = 5.243 Å, c = 11.36 Å, and υ (cell volume) = 312.50 Å 3 [16] . It indicates that the crystal lattice and basic structure of Na 0.5 Gd 0.5 WO 4 host can be obtained successfully, and the Ln 3+ cations replace the Gd 3+ which is eightfold coordinated by oxygen atoms with D 2d point symmetry. SEM image ( Fig. 1 b) shows that the morphology was nearly prismatic like shape and the particle size is about 1–3 μm. The observed results from the as-prepared Na 0.5 Gd 0.5 WO 4 phosphor particles with prismatic like shapes also confirm the characteristic growth of the sample with tetragonal phase microstructure. It is known that the co-doping behavior can increase the efficiency of luminescence, and also induces UC luminescence between the donor and acceptor ions in some cases [13,14,17] . Yb 3+ was chosen as the co-doping ion with Tm 3+ or Ho 3+ , because it possessed a large absorption cross-section at 980 nm. Therefore, the UC spectra of Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ and Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Ho 3+ samples under 980 nm excitation with pumping power of 20 mW were measured and illustrated in Fig. 2 a . As seen in Fig. 2 a, Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ samples show a strong blue luminescence at 473 nm, corresponding to the Tm 3+ 1 G 4 → 3 H 6 transition. Whereas, Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Ho 3+ samples show the bright orange emission, which is ascribed to the combination of the two primary bands in the green and red emission regions maximized at 543 nm and 655 nm, and they are assigned to Ho 3+ 5 F 4 ( 5 S 2 ) → 5 I 8 (543 nm), and Ho 3+ 5 F 5 → 5 I 8 (655 nm) transitions, respectively. The present results prove that Tm 3+ - and Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 can emit their corresponding characteristic UC luminescence upon 980 nm excitation. To estimate the possibility of producing white UC luminescence in the same sample with only one excitation wavelength, the Na 0.5 Gd 0.5 WO 4 materials doped with various concentrations of Yb 3+ /Tm 3+ /Ho 3+ have been firstly investigated in this study, and their UC spectra are given in Fig. 2 b. It is found that each emission spectrum consists of the blue, green, and red UC emissions which correspond to the transitions 1 G 4 → 3 H 6 of Tm 3+ , 5 F 4 ( 5 S 2 ) → 5 I 8 , and 5 F 5 → 5 I 8 of Ho 3+ ions, respectively. Further, by fixing the Yb 3+ and Tm 3+ concentrations, color-tunable UC emission properties can be found when adjusting Ho 3+ concentration. Among them, 10%Yb 3+ /1%Tm 3+ /0.4%Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 sample shows a strong white light emission and is clearly visible to the naked eye at a pumping power as low as 20 mW demonstrating the high efficiency of the upconversion process. In order to find the detailed variation of UC emissions behaviors [10,11] , Fig. 3 a gives the dependence of the intensities of the blue (477 nm), green (543 nm) and red (655 nm) emission bands on the Ho 3+ content with the invariable Yb 3+ and Tm 3+ content. As shown in Fig. 3 a, the emission intensities of green, and red light, which originate from the different transitions of the same Ho 3+ ions, have the same variation, and increase with increasing Ho 3+ content. While the emission intensity of blue light, ascribed to 1 G 4 → 3 H 6 of Tm 3+ , firstly increase, and then decrease with increasing Ho 3+ content. As a summarization, Table 1 lists various optical property parameters for the Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ / x Ho 3+ samples. It is also found that 10%Yb 3+ /1%Tm 3+ /0.4%Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 sample has equal relative intensities ratio of 1:1.02:0.91 for blue, green, and red UC emissions. To measure the color of the visible emission that the human eye perceives, the Commission Internationale de l′éclairage (CIE) coordinates were calculated. The calculated color coordinates for the Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ / x Ho 3+ samples are listed in Table 1 , and it is also marked as sites a–e in CIE chromaticity diagram, which all fall within the valid range for the white light emission ( Fig. 3 b). As also given in the inset of Fig. 3 (b), the white light emission can be clearly observed from the digital photograph. So we can propose that the white luminescence upon 980 nm near-infrared excitation can be produced via an UC process by tuning dopant ions based on the above spectral analysis. But we also noticed that future work is needed to be done to further adjust the relative concentrations for the dopant ions in order to optimize white light emission in this system. To investigate the UC mechanisms, Fig. 4 gives the UC luminescence spectra for Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ /0.4%Ho 3+ samples under 980 nm excitation at different pumping power. The UC emission intensities increase gradually with increasing pumping power from 20 mW to 60 mW. Based on the UC luminescence spectra, the upconverted luminescence intensity I of the blue ( 1 G 4 → 3 H 6 of Tm 3+ ), green ( 5 F 4 ( 5 S 2 ) → 5 I 8 of Ho 3+ ), and the red ( 5 F 5 → 5 I 8 of Ho 3+ ) transitions was measured as a function of the pumping power P , and the pumping power dependences of the blue, green, and red radiations were measured and displayed in the inset of Fig. 4 . The relationship between luminescence intensity I and pumping power P can be approximately expressed as follows: log( I ) ∝ (log P ) n , where n is the number of infrared photons absorbed for emitting a visible photon [10,14] . In the double-log coordinate, the slope of log( I ) ∝ (log P ) n indicates the value of n , which is used for the deduction of the possible upconversion luminescence process. As shown in the inset of Fig. 4 , the slope of curve log( I ) versus (log P ) was determined to be 2.38, 1.86, and 1.75 for the blue, green, and red emissions, respectively, allowing us to therefore propose that two-photons process in the green and red Ho 3+ UC luminescence processes. And a three-photon process was expected for the upconverted blue Tm 3+ emission. Accordingly, Fig. 5 shows the energy level diagrams of the Tm 3+ , Ho 3+ , and Yb 3+ ions as well as the proposed UC mechanisms to produce the white emission in Na 0.5 Gd 0.5 WO 4 host. It is well-known that the Yb 3+ ions can efficiently sensitize Tm 3+ and Ho 3+ ions, respectively. Hence, it is reasonable to believe that the main pathways to produce visible light also come from the energy transfer processes from Yb 3+ to Tm 3+ and Ho 3+ ions, respectively. It is found that the blue UC emission comes from the Yb 3+ –Tm 3+ pairs via a well-known three-photon process, while the green and red bands arise from Yb 3+ –Ho 3+ pairs via a two-photon process, as shown in Fig. 5 . By adjusting the relative concentration of Yb 3+ /Tm 3+ /Ho 3+ for the control of emission intensities of blue, green, and red UC emissions, bright white luminescence upon 980 nm semiconductor laser excitation can be realized via the mentioned above UC process. 4 Conclusions In conclusion, white light emission from Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 materials is achieved in the present study, and the optimum chemical composition of Na 0.5 Gd 0.5 WO 4 :10%Yb 3+ /1%Tm 3+ /0.4%Ho 3+ as white light phosphor has been determined. Bright white luminescence upon 980 nm semiconductor laser excitation comes from the combination of the blue, green, and red UC emissions which correspond to the transitions 1 G 4 → 3 H 6 of Tm 3+ , 5 F 4 ( 5 S 2 ) → 5 I 8 , and 5 F 5 → 5 I 8 of Ho 3+ ions, respectively. The calculated optimum color coordinates for white UC luminescence Yb 3+ /Tm 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 materials are (0.25, 0.39), which fall well within the white region. Generation of white light from Ln 3+ -doped rare earth tungstate matrix has potential application for lighting and displays. Acknowledgements This present work was supported by the Ph.D. Programs Foundation of Ministry of Education of China (Grant No. 20090022120002 ), the Fundamental Research Funds for the Central Universities , the National Natural Science Foundations of China (Grant Nos. 20876002 and 20976002 ), and the Beijing Natural Science Foundation (Grant Nos. 2082009 and 2091002 ). References [1] G. Blasse B.C. Grabmaier Luminescent Materials 1994 Springer Verlag Berlin [2] S. Nakamura M. Senoh T. Mukai Appl. Phys. Lett. 62 1993 2390 [3] G. Sinha A. Patra Chem. Phys. Lett. 473 2009 151 [4] Y.-H. Won H.S. Jang W.B. Im D.Y. Jeon J.S. Lee Appl. Phys. Lett. 89 2006 231909 [5] W.J. Ding J. Wang Z.M. Liu M. Zhang Q. Su J.K. Tang J. Electrochem. Soc. 155 2008 J122 [6] H. Qian Z. Li Y. Zhang Nanotechnology 19 2008 255601 [7] F. Wang X. Liu J. Am. Chem. Soc. 130 2008 5642 [8] Z. Yu Q. Yang C. Xu Y. Liu Mater. Res. Bull. 44 2009 1576 [9] S. Sivakumar F.C.J.M. van Veggel M. Raudsepp J. Am. Chem. Soc. 127 2005 12464 [10] G. Chen Y. Liu Y. Zhang G. Somesfalean Z. Zhang Q. Sun F. Wang Appl. Phys. Lett. 91 2007 133103 [11] J. Yang C. Zhang C. Peng C. Li L. Wang R. Chai J. Lin Chem. Eur. J. 15 2009 4649 [12] V. Mahalingam F. Mangiarini F. Vetrone V. Venkatramu M. Bettinelli A. Speghini J.A. Capobianco J. Phys. Chem. C 112 2008 17745 [13] Y. Pan Q. Zhang Mater. Sci. Eng. B: Sol. 138 2007 90 [14] G. Yi B. Sun F. Yang D. Chen Y. Zhou J. Cheng Chem. Mater. 14 2002 2910 [15] J. Wang X. Jing C. Yan J. Lin F. Liao J. Lumin. 121 2006 57 [16] J. Liao B. Qiu H. Lai J. Lumin. 129 2009 668 [17] Y. Bai Y. Wang G. Peng W. Zhang Y. Wang K. Yang X. Zhang Y. Song Opt. Commun. 282 2009 1922",
        "keywords": [
            "A. Optical materials",
            "C. X-ray diffraction",
            "D. Optical properties"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Wei Zhou",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2010
    },
    "jMvQl4do": {
        "id": "jMvQl4do",
        "title": "Luminescence properties of SrB4O7:Sm2+ for light conversion agent",
        "abstract": "A deep red-emitting SrB4O7:Sm2+ phosphor for light conversion agent was synthesized by the conventional solid-state reaction. X-ray powder diffraction (XRD) analysis confirmed the phase formation of SrB4O7:Sm2+ materials. Results of luminescence properties showed that the phosphor could be efficiently excited by the UV-vis light region from 250-500 nm, and it exhibited deep red (685 nm) emission corresponding to 5D0→7F 0 transition of Sm2+. The critical quenching concentration of Sm2+ in SrB4O7:Sm2+ phosphor was about 0.05, and the corresponding concentration quenching mechanism was verified to be the dipole-dipole interaction according to the Dexter's theory. The decay times had few alterations with different concentrations in SrB 4O7:xSm2+ phosphor. © 2012 The Chinese Society of Rare Earths.",
        "keywords": [
            "light conversion agent",
            "photoluminescence",
            "rare earths",
            "sm2+"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiaotang Liu",
                "org": "South China Agricultural University(South China Agricultural University),Guangzhou,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2012
    },
    "gfJM7w4q": {
        "id": "gfJM7w4q",
        "title": "Combustion synthesis and luminescence properties of blue NaBaPO4:Eu2+ phosphor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "xiangyan zhang",
                "org": ""
            },
            {
                "name": "d u haiyan",
                "org": ""
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2012
    },
    "SgX46ikx": {
        "id": "SgX46ikx",
        "title": "Bright white up-conversion emission from Er3+/Ho3+/Tm3+/Yb3+ co-doped YVO4 phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "jicheng zhu",
                "org": ""
            },
            {
                "name": "xiaotang liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2013
    },
    "SOKjQ0oP": {
        "id": "SOKjQ0oP",
        "title": "Synthesis, structure and luminescence properties of Y(V,P)O4:Eu3+,Bi3+ phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": ""
            },
            {
                "name": "Jianbo Xian",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100048, China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "School of Materials Sciences and Technology, China University of Geosciences, Beijing 100083, China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100048, China"
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2010
    },
    "TABtywoI": {
        "id": "TABtywoI",
        "title": "Luminescence properties of a new green emitting Eu2+-doped barium chlorosilicate phosphor",
        "abstract": "A new intense green light-emitting phosphor, the Eu2+-doped (BaO-BaCl2-SiO2) phosphor system, was synthesized at 800°C by the conventional high-temperature solid-state reaction. Its structure and luminescence properties were investigated by using thermogravimetry-differential scanning calorimetry (TG-DSC), X-ray diffraction (XRD), diffuse reflection spectra, photoluminescence (PL) and photoluminescence excitation (PLE) spectra. The photoluminescence spectrum reveals that this phosphor can be efficiently excited by near-ultraviolet (UV) light and blue light in the wavelength region covering 280 and 480 nm, which perfectly matches the emission wavelength of near-UV light-emitting diodes (LEDs). It emits an intense green light peaking at 502 nm, which is promising to develop possible applications for white LEDs. © 2009 Springer-Verlag.",
        "keywords": [
            "78.20.-l"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Applied Physics B: Lasers and Optics",
        "year": 2009
    },
    "YUdLy32a": {
        "id": "YUdLy32a",
        "title": "Preparation and characterization of Yb~(3+),Er~(3+) and Eu~(3+)-codoped TiO_2 nanobelts",
        "abstract": "Yb3+,Er3+ and Eu3+-codoped anatase TiO2 nanobelts were obtained simply through two-step exchangeable and hydrothermal processes.Such tri-cation-doping has not damaged TiO2 structure and morphology yet.The optical measurement results show that as rare earth doping concentration is low,the positions of up-converted emission peaks arised from Yb3+and Er3+ co-dopants,whereas the luminescent emission peak of Er3+ dopants can be observed due to the excitation of up-conversion emission,and simultaneously,the down-conversed emissions of Eu dopants are not affected by Yb3+and Er3+ co-dopants.The investigation of the up-conversion emissions of the rare-earth-doped products demonstrates that such emissions are two-phonon processes,which are markedly influenced by TiO2 matrix and Eu-doping.",
        "keywords": [
            "down-conversion",
            "hydrothermal preparation",
            "TiO2 nanobelts",
            "rare-earth-doping",
            "up-conversion"
        ],
        "authors": [
            {
                "name": "LI Li",
                "org": "College of Science,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "LEI Jing-guo",
                "org": "Department of Materials Science and Engineering,Luoyang Institute of Science and Technology,Luoyang ,China"
            },
            {
                "name": "JI Tian-hao",
                "org": "College of Science,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Science,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Science,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Journal of Functional Materials",
        "year": 2012
    },
    "OKUaD23z": {
        "id": "OKUaD23z",
        "title": "Comparative study on luminescent properties of NaYF4:Tm3+, Yb3+ with three precipitator",
        "abstract": "The NaYF4:Tm3+, Yb3+ materials were prepared by co-precipitation method with EDTA, citric acid and H2C2O4, respectively. The effects of complexing agents, precipitation temperature and combustion temperature were investigated on the luminescent properties, particle size and morphology by X-ray diffraction, SEM and fluorescence spectrum. The results showed that the best luminescence material NaYF4:Tm3+, Yb3+ can be obtained by selecting H2C2O4 as precipitator. The siring at 600°C for 5 h.",
        "keywords": [
            "Co-precipitation",
            "Luminescent property",
            "Rare earths"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiping Yang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2009
    },
    "e9C57Tti": {
        "id": "e9C57Tti",
        "title": "Photoluminescence studies on a new redemitting Sm3+-doped alkaline-earth vanadate phosphor: Ca3Sr3(VO4)4: Sm3+, Na+",
        "abstract": "A series of new red-emitting Ca3Sr3-2x(VO4)4:xSm3+,xNa+phosphorsweresynthesized by a solid-reactionmethod.XRD phase analysis results indicate that the sample begins to crystallize at 800°C, and single-phase Ca3Sr3(VO4)4is fully obtained after annealing at 1000 oC. The as-prepared phosphors havegood excitation propertiesin the region of 350-450 nm, which perfectly match the emission wavelength of near-UV light-emitting diodes (LEDs).Three characteristic emissionspeaking at 563, 601 and 646 nmcan be obtained upon 406 nm excitation with the chromaticity coordinates of (0.654, 0.321), which are due to 4G5/2- 6H5/2, 4G5/2- 6H7/2and 4G5/2- 6H9/2transitions of Sm3+ions. Further, the concentration quenching and corresponding luminescence mechanisms of Ca3Sr3-2x(VO4)4: xSm3+, xNa+phosphorswere also discussed, and the critical distance was determined to be about 7.75 Å.",
        "keywords": [
            "Optical materials",
            "Optical properties",
            "Phosphors",
            "White LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Randi Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianfeng Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Optoelectronics and Advanced Materials, Rapid Communications",
        "year": 2011
    },
    "WC5uIHOF": {
        "id": "WC5uIHOF",
        "title": "Synthesis and Up-Conversion Luminescence Properties of BaYF_5…Yb~(3+)/Er~(3+) Nanocrystals",
        "abstract": "Yb3+ and Er3+ co-doped BaYF5 up-conversion nanocrystals are prepared by hydrothermal method.The sample is characterized by scanning electron microscopy and X-ray diffraction.Upon 980 nm laser diode excitation,the effect of hydrothermal synthesis temperatures on up-conversion luminescence properties is discussed.Results show that the sample obtained at 200 ℃ has larger green emission intensity than that of other samples,while the sample synthesized by hydrothermal method at 220 ℃ has the average grain size about 100 nm.According to the law of luminescence intensity versus excitation power,the 523 and 546 nm green emission,649 and 667 nm red emission are all due to the double-photon process.The up-conversion mechanism and processes are also analyzed.",
        "keywords": [
            "luminescence",
            "bayf5\\:yb3+/er3+",
            "hydrothermal method",
            "optical materials",
            "up-conversion"
        ],
        "authors": [
            {
                "name": "Sun Jiayue",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "Zhang Weihang",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "Zhou Wei",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Laser & Optoelectronics Progress",
        "year": 2010
    },
    "zGt2Qpki": {
        "id": "zGt2Qpki",
        "title": "Sol–gel synthesis and green upconversion luminescence in BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphors",
        "abstract": "",
        "keywords": [
            "emission line",
            "sol gel method",
            "excited states"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yujing lan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            },
            {
                "name": "haiyan du",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Optical Materials",
        "year": 2011
    },
    "Lu1tahRm": {
        "id": "Lu1tahRm",
        "title": "Photoluminescence properties and energy transfer of Ce 3+ , Eu 2+ co-doped Sr 3 Gd(PO 4 ) 3 phosphor",
        "abstract": "",
        "keywords": [
            "x ray diffraction",
            "chemical synthesis"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "junhui zeng",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2012
    },
    "t8HoWa02": {
        "id": "t8HoWa02",
        "title": "Synthesis and optical properties of green-emitting MSrAl3O7:Eu2+(M=Y, La, Gd) phosphors for white light-emitting diodes",
        "abstract": "A series of green-emitting phosphors with compositions of MSrAl3O7:Eu2+(M=Y, La, Gd) were prepared by the traditional solid-state method. Their structural phases were investigated using X-ray diffraction (XRD) technique, and it was found that these phosphors belonged to some stable crystal phase in M2O3-SrO-Al2O3 pseudo-ternary system room-temperature optical properties for MSrAl3O7:Eu2+(M=Y, La, Gd) phosphors were analyzed by the UV-vis diffuse reflectance spectroscopy, excitation and emission spectroscopy. It was found that, MSrAl3O7:Eu2+(M=Y, La, Gd) phosphors showed broad excitation in the near ultraviolet region (300-450 nm), and they all exhibited green light with peak wavelength at 517 nm, which indicated that they were promising as the green component of light-conversion phosphors for white LEDs. Further investigations for MSrAl3O7:Eu2+(M=Y, La, Gd) phosphors indicated that LaSrAl3O7:Eu2+ showed the strongest green emission, and the optimum reaction temperture was 1400°C, at which stable crystal structure and excellent optical properties could be obtained.",
        "keywords": [
            "Green luminescence materials",
            "Photoluminescence",
            "White LED"
        ],
        "authors": [
            {
                "name": "XIA Zhi-guo",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "WANG Xue-feng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2009
    },
    "Hvn0c9BJ": {
        "id": "Hvn0c9BJ",
        "title": "Preparation and up-conversion fluorescence of rare earth (Er 3+ or Yb 3+ /Er 3+ )-doped TiO 2 nanobelts",
        "abstract": "",
        "keywords": [
            "ion exchange",
            "hydrothermal"
        ],
        "authors": [
            {
                "name": "tianhao ji",
                "org": "beijing technology and business university"
            },
            {
                "name": "yang liu",
                "org": "beijing technology and business university"
            },
            {
                "name": "hui zhao",
                "org": "beijing technology and business university"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            },
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "guanglu ge",
                "org": ""
            }
        ],
        "venue": "Journal of Solid State Chemistry",
        "year": 2010
    },
    "lprZszoe": {
        "id": "lprZszoe",
        "title": "Near-infrared quantum cutting in Eu2+, Yb3+ co-doped Sr3Gd(PO4)3 phosphor",
        "abstract": "An efficient Near-Infrared (NIR) quantum cutting (QC) in Eu 2+-Yb3+ co-doped Sr3Gd(PO4) 3 phosphor has been investigated. Upon excitation of Eu2+ with an ultraviolent (UV) photon at 343 nm, two NIR emissions have been obtained from 2F7/2 → 2F5/2 transition of Yb3+. The luminescence spectra both in visible (VIS) and NIR regions and decay lifetime curves of Eu2+ have been measured to prove energy transfer (ET) from Eu2+ to Yb3+. The highest energy transfer efficiency (ETE) related to Yb3+ concentration was found to be 85.3%. So that the Sr3Gd(PO4)3 co-doped with Eu2+ and Yb3+ may be candidates to modify the spectral and improve the solar cell efficiency. © 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "lanthanides",
            "optical materials",
            "quantum cutting",
            "solar energy materials"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Optical Materials",
        "year": 2013
    },
    "9FdRxz9F": {
        "id": "9FdRxz9F",
        "title": "Synthesis and luminescence properties of red emitting phosphors Na 3CaB 5O 10:Eu 3+",
        "abstract": "A series of new Na3CaB5O10:Eu3+ phosphor was synthesized by a solid-state reaction method, and its luminescent properties were investigated. The phase formation of phosphors was confirmed by X-ray powder diffraction (XRD). The excitation spectra exhibited that the phosphors could be effectively excited by near ultraviolet (392 nm) and blue (464 nm) light, which perfectly match the emission wavelength of near-UV light-emitting diodes (LEDs). The emission spectra showed that two characteristic red emission lines peaking at 592 and 613 nm can be obtained upon 394 and 463 excitation with the chromaticity coordinates of (0.6347, 0.3649), which are due to D-5(0)-F-7(1) and D-5(0)-F-7(2) transitions of Eu3+ ions. The effect of Eu3+ concentration on the emission spectrum of Na3CaB5O10:Eu3+ phosphor was studied. The results showed that the emission intensity increased with increasing Eu3+ concentration, and then decreased because of concentration quenching. The obtained results indicated that this phosphor could be a promising candidate for near-UV white LEDs.",
        "keywords": [
            "luminescence",
            "white LED",
            "concentration quenching"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Jinli Lai",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "MANUFACTURING SCIENCE AND TECHNOLOGY, PTS 1-3",
        "year": 2011
    },
    "gEkOeYyP": {
        "id": "gEkOeYyP",
        "title": "Hydrothermal synthesis of BaYF5:Yb3+/Er3+ upconversion luminescence submicrospheres by a surfactant-free aqueous solution route",
        "abstract": "Research highlights ► BaYF 5 :Yb 3+ /Er 3+ upconversion luminescence submicrospheres have been first prepared in this paper. ► The size and shape of BaYF 5 :Yb 3+ /Er 3+ were controlled by adjusting the fluoride sources, temperature and reaction time. ► A systematic study on the photoluminescence of Yb 3+ /Er 3+ -doped BaYF 5 samples with different size and shapes has shown that the optical properties of products are strongly dependent on their size.",
        "keywords": [
            "D. Luminescence",
            "B. Chemical synthesis",
            "A. Optical materials"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100048, China"
            },
            {
                "name": "Jianbo Xian",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100048, China"
            },
            {
                "name": "Haiyan Du",
                "org": ""
            }
        ],
        "venue": "Journal of Physics and Chemistry of Solids",
        "year": 2011
    },
    "4VGwLgZY": {
        "id": "4VGwLgZY",
        "title": "Preparation and Characterization of Room-temperature Ferromagnetic Ni-doped TiO2 Nanobelts",
        "abstract": "Ni-doped anatase TiO 2 nanobelts (NBs) with different Ni 2+ contents were simply prepared by combining ion-exchange with hydrothermal treatment. They were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), and magnetic measurement techniques. The results showed that Ni 2+ cations doped into the TiO 2 lattice and no metallic nickel clusters or nanoparticles could be found. The magnetic results demonstrated that the prepared Ni-doped TiO 2 samples had complex magnetic mechanism including room-temperature ferromagnetic and paramagnetic behaviors, and with the increase of Ni 2+ content, the magnetization also increased under the same applied field owing to uniform distribution of Ni 2+ ions in TiO 2 nanobelts.",
        "keywords": [
            "Room-temperature ferromagnetic",
            "Ni-doped TiO 2",
            "Diluted magnetic semiconductor",
            "Nanobelts"
        ],
        "authors": [
            {
                "name": "Hongye Zhang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, P. R. China"
            },
            {
                "name": "Tianhao Ji",
                "org": "Beijing Univ Aeronaut & Astronaut, Sch Mat Sci & Technol, Beijing 100083, Peoples R China"
            },
            {
                "name": "Linglong Li",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, P. R. China"
            },
            {
                "name": "Xingyi Qi",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, P. R. China"
            },
            {
                "name": "Yifan Liu",
                "org": "State Key Laboratory of Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, P. R. China"
            },
            {
                "name": "Jianwang Cai",
                "org": "State Key Laboratory of Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, P. R. China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, P. R. China"
            },
            {
                "name": "Jiayue Sun",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, P. R. China"
            }
        ],
        "venue": "Acta Physico Chimica Sinica",
        "year": 2008
    },
    "v24xJLNr": {
        "id": "v24xJLNr",
        "title": "Stokes and anti-stokes luminescence research of NaYF4:Eu3+, Tm3+, Yb3+]",
        "abstract": "The sample of NaYF4:Eu,Tm,Yb was synthesized by coprecipitation method. The emission of NaYF4:Eu,Tm,Yb excited by 360 nm is blue light with the peak at 452 nm from the transition of (1)D2-->(3)F4 of Tm3+. After being excited by 395 nm, NaYF4:Eu,Tm,Yb emits orange light with the peak at 591 nm originating from the transition of (5)D0-->(7)F1 of Eu3+. When excited by 409 nm, NaYF4:Eu,Tm,Yb emits red light with the peak at 613 nm from the transition of (5)D0-->(7)F2 of Eu3+. The color of upconversion luminescence of NaYF4:Eu,Tm,Yb excited by 980 nm was blue and red. The upconversion spectrum exhibits distinct emission peaks at 459, 478 and 641 nm. The blue light comes from the transition of (1)G4--(3)H6 and (1)D2-->(3)F4 of Tm3+. The absorption spectrum was also researched. The red light results from the transition of (1)G4--(3)F4 of Tm3+. The slope of the emission of 474 and 646 nm is 2.1 and 2.4 respectively. The emission of 478 and 641 nm is all due to three photon process. The structural properties of sample were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results show that NaYF4:Tm3+,Yb3+ prepared by coprecipitation method exhibits a hexagonal crystal.",
        "keywords": [
            "stokes and anti-stokes luminescence",
            "tm3+",
            "co-precipitation method",
            "yb3+",
            "rare earth ion",
            "product of nayf4:eu3+"
        ],
        "authors": [
            {
                "name": "Hai-yan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhi-ping Yang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jia-yue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2009
    },
    "0FCM4E6e": {
        "id": "0FCM4E6e",
        "title": "Near-infrared-to-green upconversion in Yb3+/Er3+ co-doped BaYF5by chemical co-precipitation method",
        "abstract": "Barium yttrium fluorides ( BaYF5) co-doped with Er3+ and Yb3+ were synthesized by the chemical co-precipitation method and the structural and optical properties of solution-processed Er 3+/Yb3+ co-doped BaYF5 were characterized. Intense visible emissions centered at around 523, 546 and 658 nm, originated from the transitions of 2H11/2 → 4I 15/2, 4S3/2 → 4I 15/2, and 4F9/2 → 4I 15/2 of Er3+, respectively, have been observed in samples upon excitation with a 980nm laser diode, and the involved mechanisms have been explained. © (2011) Trans Tech Publications.",
        "keywords": [
            "Chemical co-precipitation method",
            "Energy transfer",
            "Luminescent properties"
        ],
        "authors": [
            {
                "name": "hai yan du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "wei hang zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "jia yue sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "IBNxZvS9": {
        "id": "IBNxZvS9",
        "title": "Preparation and Characterization of the Mica Titanium Optical Interferential Pigment Coated by Nd_2O_3",
        "abstract": "Nd_2O_3/TiO_2/Mica pearlescent pigment was prepared by means of homogenous precipitation with urea on the surface of green mica titanium by coating rare earths Nd_2O_3. The influence of the content of Nd_2O_3 on the pearl effect and UV absorb characteristic was investigated. The UV absorb capability of 5%Nd_2O_3/TiO_2/Mica is higher than that of mica titanium, and UV shielding characteristic works well with the best pearl effect of green-mauve optically variable. Optically variable pigments with different colors can be produced by this preparation.",
        "keywords": [
            "mica titanium",
            "UV absorb",
            "pearlescent pigment",
            "optically variable",
            "rare earths Nd_2O_3"
        ],
        "authors": [
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "GUO Meng-meng",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "WU Ai-ping",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Bulletin of the Chinese Ceramic Society",
        "year": 2006
    },
    "NmT05S70": {
        "id": "NmT05S70",
        "title": "Size and shape controllable synthesis of oil-dispersible BaYF 5 :Yb 3+ /Er 3+ upconversion fluorescent nanocrystals",
        "abstract": "",
        "keywords": [
            "chemical synthesis",
            "luminescence"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "jianbo xian",
                "org": ""
            },
            {
                "name": "xiangyan zhang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2011
    },
    "TNnRUVh4": {
        "id": "TNnRUVh4",
        "title": "Synthesis and photochromic properties of bromo substituent indolinobenzospiropyran compounds",
        "abstract": "A compound of 6, 8-dibromo-1′, 3′, 3′-trimethyl-spiro [2H-1-benzopyran-2, 2′-ind-oline] was designed and synthesized. The structure of the compound was characterized by 1H-NMR, IR, elemental analysis, melting point and solid-phase analysis by X-ray power diffraction. The color of the compound in acetone solution changed from colorless to blue after irradiated by 365 nm UV, and returned to colorless when the irradiation was stopped or in dark. This phenomenon occurrence is because the reversibility of the transformation between the colorless spiro forms and the colored merocyanines. The results indicated that the synthesized compound had a better photochromic property.",
        "keywords": [
            "Indolinobenzospiropyran",
            "Photochromism",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Yi Dong Ji",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "WU Ai-ping",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2008
    },
    "mWgu4oft": {
        "id": "mWgu4oft",
        "title": "Luminescence properties of double-perovskite Sr<sub>2</sub>Ca<sub>1−2<i>x</i></sub>Eu<sub><i>x</i></sub>Na<sub><i>x</i></sub>MoO<sub>6</sub> red-emitting phosphors prepared by the citric acid-assisted sol–gel method",
        "abstract": "Double-perovskite Sr2Ca1−2x\n Eu\n x\n Na\n x\n MoO6 red-emitting phosphors were prepared by the citric acid-assisted sol–gel method, and their luminescence properties were investigated\n as a function of sintering temperature and Eu3+-doping concentration. B-site substituted Sr2Ca0.8Eu0.1Na0.1MoO6 phosphor, in which Na+ ions act as charge compensators, was selected to study the thermal behavior, phase structure, microstructure, and photoluminescence\n property under different sintering temperatures. The photoluminescence studies on Sr2Ca1−2x\n Eu\n x\n Na\n x\n MoO6 (x = 0.02, 0.05, 0.10, 0.15, 0.2) show that a dominant red emission line at around 594 nm, which is due to the Eu3+ magnetic dipole transition of 5D0–7F1, is observed under different Eu3+ excitations (396 and 412 nm). Further, Eu3+ dopant content dependent emission spectra investigations of Sr2Ca1−2x\n Eu\n x\n Na\n x\n MoO6 phosphors indicates that, when the Eu3+ concentrations x = 0.05, there are minimum differences between the emission intensity of 5D0–7F1 transition at 594 nm and that of 5D0–7F2 transition at 615 nm. With increasing Eu3+ concentration, the variation of the emission intensities between the two transitions keep nearly invariable and Sr2Ca0.8Eu0.1Na0.1MoO6 phosphor has the strongest red emission in this series.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences School of Materials Sciences and Technology Beijing 100083 China"
            },
            {
                "name": "Jianfeng Sun",
                "org": "Beijing Technology and Business University College of Chemistry and Environmental Engineering Beijing 100048 China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology and Business University College of Chemistry and Environmental Engineering Beijing 100048 China"
            },
            {
                "name": "Daimei Chen",
                "org": "China University of Geosciences School of Materials Sciences and Technology Beijing 100083 China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology and Business University College of Chemistry and Environmental Engineering Beijing 100048 China"
            }
        ],
        "venue": "",
        "year": 2010
    },
    "We4hfL4U": {
        "id": "We4hfL4U",
        "title": "Tunable luminescence of Ce3+/Mn2+-coactivated Sr 3Gd(PO4)3 with efficient energy transfer for white-light-emitting diode",
        "abstract": "A series of new luminescent emission-tunable phosphors Sr 3Gd(PO4)3(SGP):0.006Ce3+, xMn 2+ have been synthesized by a high-temperature solid-state reaction. The energy transfer from Ce3+ to Mn2+ in SGP:Ce 3+/Mn2+ phosphors has been validated and demonstrated to be a resonant type via a dipole-quadrupole mechanism based on the decay lifetime data, and the critical distance (RC) calculated by quenching concentration method and spectral overlap method are 25.24 and 24.26 Å, respectively. Tuning the Ce3+/Mn2+ ratio via the energy transfer varied the emission hue of from blue to white-light and eventually to yellow. These results indicate that the developed phosphor may be promising as a single-component white-light-emitting phosphor for white LEDs. © 2013 Elsevier B.V.",
        "keywords": [
            "Chemical synthesis",
            "Energy transfer",
            "Optical properties",
            "w-LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2013
    },
    "MEhIoAYm": {
        "id": "MEhIoAYm",
        "title": "Structure and upconversion luminescence properties of BaYF 5:Yb3+, Er3+ nanoparticles prepared by different methods",
        "abstract": "Research highlights ▶ Two different fluoride source were used to synthesize BaYF 5 :Yb 3+ , Er 3+ by the hydrothermal method, and the sizes of the as-prepared spherical particles were about 30 nm (NH 4 BF 4 as fluoride source) and 100 nm (NH 4 HF 2 as fluoride source). ▶ BaYF 5 :Yb 3+ , Er 3+ nanoparticles prepared by the co-precipitation method are irregular, and many clusters and agglomerates can be seen. ▶ The UC fluorescence has been realized in all the as-prepared BaYF 5 :Yb 3+ , Er 3 samples upon 980 nm excitation. Abstract BaYF 5 :Yb 3+ , Er 3+ (BYF) upconversion (UC) luminescence nanoparticles have been prepared using co-precipitation and hydrothermal techniques, respectively. Two different fluoride sources were used to synthesize BYF by the hydrothermal method, and the sizes of the as-prepared spherical particles were about 30 nm (NH 4 BF 4 as a fluoride source) and 100 nm (NH 4 HF 2 as a fluoride source), respectively. While the nanoparticles prepared by the co-precipitation method are irregular, many clusters and agglomerates can be seen. The UC fluorescence has been realized in all the as-prepared BYF samples upon 980 nm excitation. It is found that their luminescence spectra depend strongly upon the preparation method. Factors affecting the upconversion fluorescent intensity have been also studied. The UC emission transitions for 4 F 9/2 – 4 I 15/2 (red), 2 H 11/2 – 4 I 15/2 (green) and 4 S 3/2 – 4 I 15/2 (green) in the Yb 3+ /Er 3+ codoped BYF nanoparticles depending on pumping power have also been discussed. Keywords Upconversion Fluoride source Co-precipitation technique Hydrothermal synthesis 1 Introduction Rare-earth (RE) doped nano-structured materials have attracted great interests in recent years due to luminescent properties induced by their nano-scale sizes with potential applications in the field of solid state luminescence [1–5] . Owing to high quantum efficiency and lower phonon energies, fluorides doped with RE ions are very attractive materials for optical applications, which are relatively stable in air and different from chloride or bromide hosts [6–8] . Among the RE ions, the Er 3+ ion is suitable for converting infrared (IR) to the visible light through the upconversion (UC) process due to its proper electronic energy level scheme. The co-doping of the Yb 3+ ion (a sensitizer) with the Er 3+ ion can remarkably enhance the UC efficiency from infrared to visible lights due to the efficient energy transfer from Yb 3+ to Er 3+ [9–12] . Recently, many reports are focused on the modification of nano- to micro-sized fluoride phosphors, which involve selected solvent treatment, ligands and surfactants to control the size and morphology of the products. For example, Bu et al. synthesized novel Ba 2 ErF 7 and Yb 3+ -doped Ba 2 ErF 7 powder by a co-precipitation method [13] . Chen et al. reported on the comparative investigation of structure and luminescence properties of tetragonal LiYF 4 and BaYF 5 , and hexagonal NaYF 4 phosphors codoped with Er 3+ /Yb 3+ by a facile hydrothermal synthesis [14] . Furthermore, BaYF 5 in nanoscale is an ideal host for the Yb 3+ /Tm 3+ co-dopants [15] , nevertheless a correlation between the synthesized phases and the luminescence behaviors is not clearly verified. Based on this, BaYF 5 can be used as a kind of ideal host for UC materials, and some researches on the shape- and size-dependent UC luminescent behavior of BaYF 5 are expected. In the present work, the structure and upconversion luminescence properties of Yb 3+ /Er 3+ co-doped BaYF 5 samples prepared by different techniques have been studied. The particle sizes and the differences of upconversion spectra behavior between co-precipitation and hydrothermal techniques are described in detail. 2 Experimental 2.1 Synthesis Yb 3+ /Er 3+ codoped BaYF 5 nanoparticles were prepared using co-precipitation and hydrothermal techniques, respectively, and the samples were named as c-BYF and h-BYF in the following section. All the BYF samples were co-doped with 20 mol% of Yb 3+ and 6 mol% of Er 3+ with respect to the alkali-earth metal ions. Analytical grade Er 2 O 3 , Yb 2 O 3 , and Y 2 O 3 were separately dissolved in dilute HNO 3 to prepare the 0.2 mol/L stock solutions of Er(NO 3 ) 3 , Yb(NO 3 ) 3 , and Y(NO 3 ) 3 . NH 4 HF 2 and NH 4 BF 4 were dissolved in deionized water to prepare the 1 mol/L stock solutions. For a typical synthesis of BaYF 5 :20%Yb 3+ /6%Er 3+ nanocrystals, 0.5 mmol of stoichiometric RE(NO 3 ) 3 (0.2 mol/L, RE = Er, Yb, Y; Y:Yb:Er = 78:20:2) aqueous solution and 2 mL of fluoride solution (1 mol/L) were used. 2.1.1 Coprecipitation technique For a typical co-precipitation synthesis procedure, 5 mmol (Ba 2+ , 0.76Y 3+ , 0.06Er 3+ , and 0.2Yb 3+ ) was firstly mixed together, and then the mixture solution was added dropwise into25 mmol F − (NH 4 HF 2 ) ion solution under constant stirring. The obtained precipitate solutions were vigorously stirred at 50 °C for about 2 h. The white precipitate was separated by centrifugation and washed with water for several times, and then dried in a furnace at 100 °C for 24 h to obtain BYF precursors. The precursors were subsequently annealed at 900 °C in air for 4 h to obtain the final product. The as-obtained sample was used for structure and property characterization. 2.1.2 Hydrothermal technique For a typical hydrothermal synthesis procedure, 5 mmol (Ba 2+ , 0.76Y 3+ , 0.06Er 3+ , and 0.2Yb 3+ ) was added in the 25 mL solution of the metal nitrates. Then 25 mmol F − (NH 4 HF 2 /NH 4 BF 4 ) ions should be necessary to precipitate totally metals as the fluoride by the reaction above transparent solution with vigorous stirring continuously for about 20 min. Subsequently, the milky colloidal solution was transferred to a 40 mL Teflon-lined autoclave, and the autoclave was sealed and maintained at 220 °C for 24 h, and then cooled to room temperature naturally. The white precipitate was separated by centrifugation and washed with ethanol for several times, and then dried in a vacuum at 80 °C for 12 h. The as-obtained sample was used for structure and property characterization. 2.2 Characterization Powder X-ray diffraction (XRD) measurements were performed on a Shimadzu XRD-6000 diffractometer at a scanning rate of 2.0° (2 θ )/min from 20° to 85°, with Cu Kα radiation ( λ = 0.15405 nm). Transmission electron microscope (TEM) images were observed using a JEOL-2010 Electron Microscope with an acceleration voltage of 200 kV. Fourier transform infrared spectroscopy (FT-IR) data were collected on a Nicolet 380 spectrophotometer over the range of wavenumber 4000–1500 cm −1 . The photoluminescence (PL) measurements were performed on a HitachiF-4500 spectrophotometer equipped with a 150 W xenon lamp as the excitation source. The UC luminescence emission spectra were obtained on the same HitachiF-4500 spectrophotometer using a 980 nm semiconductor laser (Beijing Viasho Technology Company, China) as the excitation source. All the measurements were performed at room temperature. 3 Results and discussion 3.1 XRD analysis Fig. 1 gives the XRD patterns of the c-BYF samples (a), h-BYF samples using NH 4 BF 4 as a fluoride source (h-BYF/NH 4 BF 4 ) (b), and h-BYF samples using NH 4 HF 2 as a fluoride source (h-BYF/NH 4 HF 2 ) (c), respectively. All characteristic diffraction peaks at 2 θ = 26.3°(1 3 1), 30.38°(3 3 0), 43.55°(1 2 3), 51.37°(0 6 2), 53.80°(2 6 2), 63.09°(3 7 2), 69.79°(0 1 5), 71.42°(1 2 5), and 79.98°(2 7 4) are presented, which are in good agreement with the standard values for the bulk tetragonal BaYF 5 (JCPDS46-0039). On the basis of the above results, we conclude that it cannot change the crystal structure of the products by varying different synthesis procedure and reaction condition. Further, it is found that the diffraction peaks all shift to the higher angles direction owing to the substitution of Er 3+ and Yb 3+ ions for Y 3+ . As a result, the lattice parameters of BaYF 5 :Yb 3+ , Er 3+ were calculated by the UnitCell program [16] in the tetragonal system based on the given XRD data in Fig. 1 a, and it has an tetragonal phase and lattice constants of a C = 12.28 ± 0.07 Å, υ (cell volume) = 1010.99 ± 10.58 Å 3 . 3.2 TEM analysis TEM images were taken in order to estimate the size and evaluate the morphology of the grains of the BYF samples. A series of controlled experiments demonstrated that the shape evolutions of BYF crystals are influenced by external factors such as different methods and fluoride sources in conjunction with the intrinsic crystallographic structure of BYF crystals. Fig. 2 displays TEM images of the as-prepared c-BYF (a), h-BYF/NH 4 BF 4 (b) and h-BYF/NH 4 HF 2 (c). It is suggested that the crucial effects of synthesis conditions and fluoride sources on the crystalline phases and morphologies of the products in our current synthesis. As shown in Fig. 2 a, it is found that the c-BYF grains consist of many clusters and agglomerates, which also has many particles with clearly marked grain boundaries. This result is characteristic of materials prepared at high sintering temperature. Differently from co-precipitation technique, the hydrothermal technique does not require high temperature treatments, avoiding agglomeration and sintering of the grains. Fig. 2 b and c give the TEM images of the samples by hydrothermal method. For each h-BYF product, the grains do not form clusters and agglomerates as they are mostly separated and not sintered. When other reaction conditions remain invariable, the size of the obtained particles is about 100 nm if NH 4 BF 4 is used as a fluoride source. However, NH 4 HF 2 replaced NH 4 BF 4 as the fluoride source, and the mean size of the obtained sample is about 30 nm in diameter ( Fig. 2 c). Meanwhile, the selected area electron diffraction (SAED) pattern for h-BYF/NH 4 HF 2 sample ( Fig. 2 d) demonstrates the highly crystalline nature and confirmed the tetragonal crystalline structure of the h-BYF/NH 4 HF 2 nanoparticles. By comparing the TEM images of the samples, the grain sizes of the BYF products formed under hydrothermal method are more uniform and small than that obtained by the co-precipitation method, meanwhile, the morphologies of the products are quite different from the different fluoride source in the same hydrothermal method. For the hydrothermal method, in aqueous solution, BF 4 − (NH 4 BF 4 as fluoride source) was hydrolyzed to produce BO 3 3− , HF and F − anions, as shown in the following Eq. (1) , and then F − anions react with Ba 2+ , Y 3+ to form BYF shown in Eq. (3) . As a comparison, HF 2 − (NH 4 HF 2 as fluoride source) was directly hydrolyzed to produce HF and F − anions, as shown in the following Eq. (2) , and then F − anions react with Ba 2+ , Y 3+ to form BYF shown in Eq. (3) . It is found that the equilibrium constant of the hydrolysis reaction [Eqs. (1) and (2) ] is different in the present hydrothermal condition, which will induce different morphologies and sizes of the nanoparticles [17] . (1) BF 4 − + 3 H 2 O ↔ H 3 BO 3 + 3 HF + F − (2) HF 2 − ↔ HF + F − (3) Ba 2+ + Y 3+ + 5 F − → BYF ↓ 3.3 IR spectra and optical characterization Fig. 3 presents IR reflectance spectra recorded for as-prepared c-BYF (a), h-BYF/NH 4 BF 4 (b) and h-BYF/NH 4 HF 2 (c). As expected, the as-prepared h-BYF samples contain considerable amounts of water. Meanwhile, the content of water in h-BYF/NH 4 HF 2 (c) is larger than for as-prepared h-BYF/NH 4 BF 4 sample. These are evidenced by the broad band around 3740 cm −1 as well as narrower band observed at 1640 cm −1 , indicative of antisymmetric and symmetric stretches and HOH bending modes [18] . Fig. 4 shows the UC emission spectra of as-prepared c-BYF (a), h-BYF/NH 4 BF 4 (b) and h-BYF/NH 4 HF 2 (c) upon an excitation wavelength of 980 nm, all of which have similar spectra profile corresponding to the same wavelength except for different relative emission intensities. Three intense emission bands centered at 523, 546, and 667 nm corresponding to the transitions of 4 S 3/2 – 4 I 15/2 , 2 H 11/2 – 4 I 15/2 and 4 F 9/2 – 4 I 15/2 , respectively, were simultaneously observed. It can be seen that the upconversion fluorescence intensities of green (523 and 546 nm) and red {667 nm} emissions of Er 3+ are affected by the different methods. The UC intensity of green emission for c-BYF is larger than that of as-prepared h-BYF samples. However, the strongest emission peak occurs at 667 nm in h-BYF/NH 4 HF 2 samples ( Fig. 4 c). Fig. 5 shows the different integrated ratios for the green ( 2 H 11/2 + 4 S 3/2 − 4 I 15/2 ) and red ( 4 F 9/2 − 4 I 15/2 ) upconversion emission based on the different samples. Since the component and crystal structure are the same for c-BYF and h-BYF samples, heat-treatment temperature then becomes the reason for why they have different upconversion spectra. The very large difference in the heat-treatment temperature may have an effect on the amount of the impurity which then affects the luminescence behaviors [19] . The c-BYF samples were heat-treated at 900 °C finally, while the h-BYF samples were heated only at 80 °C. So sample heated at 80 °C will have considerable amount of the water and hydroxyl groups, probably that bounded to the surface of the powder evaporates; however, heating at 900 °C is necessary for complete removing of the stronger bounded hydroxyl groups [20,21] . Thus, the energy in the 4 S 3/2 level for the green emission will be relaxed to the lower 4 F 9/2 level, increasing the red-to-green ratio of the emission. This results from a considerable amount of water and hydroxyl groups present in the fluoride structure, which quenches the emission from the higher positioned levels [22–24] . Therefore, the water and hydroxyl groups can explain why the differences in emission spectra exist between c-BYF and h-BYF. Further, Fig. 6 gives the pumping power dependent upconversion spectra of BYF samples, suggesting that UC emission intensities increased gradually with increasing pumping power. Different UC emission intensities are observed for the three BYF samples. To investigate the fundamental UC mechanism of samples, the right presents the pumping power dependence of 2 H 11/2 ( 4 S 3/2 )– 4 I 15/2 (green) and 4 F 9/2 – 4 I 15/2 (red) transition emissions for as-prepared BYF samples. It is well known that the emission intensity ( I f ) will be proportional to some power ( n ) of the infrared excitation power ( P ) [25] : (4) I f ∝ P n where n is the number of photons required to populate the emitting state. The results are shown in Fig. 6 for different samples. These results show that two-photon process is responsible for green and red emissions to the three BYF samples. The excited states for upconversion can be populated by several well-known mechanisms: (1) excited state absorption (ESA) and (2) energy transfer (ET) [26–28] . Fig. 7 shows the energy level diagram of Er 3+ and Yb 3+ ions as well as the proposed upconversion mechanisms accounting for the green and red emissions under 980 nm laser excitation [29–31] . In the complex Yb 3+ /Er 3+ codoped BYF system, an initial energy transfer from an Yb 3+ ion in the 2 F 5/2 state to an Er 3+ ion populates the 4 I 11/2 level. A second 980 nm photon, or energy transfer from an Yb 3+ ion, can then populate the 4 F 7/2 level of the Er 3+ ion. The Er 3+ ion can then relax nonradiatively to the 2 H 11/2 and 4 S 3/2 levels, and the green 2 H 11/2 – 4 I 15/2 and 4 S 3/2 – 4 I 15/2 emissions occur. Alternatively, the ion can further relax and populate the 4 F 9/2 level leading to the red 4 F 9/2 – 4 I 15/2 emission. The 4 F 9/2 level may also be populated from the 4 I 13/2 level of the Er 3+ ion by absorption of a 980 nm photon, or energy transfer from an Yb 3+ ion, with the 4 I 13/2 state being initially populated via the nonradiative 4 I 11/2 – 4 I 13/2 relaxation [21] . 4 Conclusions BaYF 5 :Yb 3+ , Er 3+ (BYF) materials have been prepared using two different techniques. The size and morphology of the as-prepared particles depend upon the preparation technique. The UC fluorescence has been realized in the as-prepared BYF samples upon 980 nm excitation. The UC emission transitions for both 2 H 11/2 ( 4 S 3/2 )– 4 I 15/2 (green) and 4 F 9/2 – 4 I 15/2 (red) in the BYF:Yb 3+ , Er 3+ samples came from two-photon UC processes. Obvious differences in fluorescent emission spectra between c-BYF and h-BYF powders were observed. The UC intensity of green emission in c-BYF is larger than that of as-prepared h-BYF samples, while the strongest emission peak occurs at 667 nm in h-BYF/NH 4 HF 2 samples. The impurities of water and hydroxyl groups and the surface effect were suggested to account for the upconversion luminescence differences between the c-BYF and the h-BYF materials. Acknowledgements This work was supported by the National Natural Science Foundation of China (No. 20976002 and No. 20876002 ), the Beijing Natural Science Foundation (No. 2091002 , and No. 2082009 ), and Funding Project for Academic Human Resources Development in the Institution of Higher Learning Under the Jurisdiction of Beijing Municipality. References [1] F.Z. Shan D.Q. Chen Y.L. Yu P. Huang F.Y. Weng H. Lin Y.H. Wang Mater. Res. Bull. 45 2010 1017 1020 [2] L. Kassab F. Bomfim J. Martinelli N. Wetter J. Neto C.B. de Araujo Appl. Phys. B 94 2009 239 242 [3] Z.G. Chen Q.W. Tian Y.L. Song J.M. Yang J.Q. Hua J. Alloys Compd. 506 2010 L17 L21 [4] W.P.Q.D.S. Zhang D. Zhao L.L. Wang K.Z. Zheng Chem. Commun. 46 2010 2304 2306 [5] Y.Q. Qu X.G. Kong Y.J. Sun Q.H. Zeng H. Zhang J. Alloys Compd. 485 2009 493 496 [6] F.Y. Weng D.Q. Chen Y.S. Wang Y.L. Yu P. Huang H. Lin Ceram. Int. 35 2009 2619 2623 [7] G.J. De W.P. Qin J.S. Zhang J.S. Zhang Y. Wang C.Y. Cao Y. Cui J. Lumin. 122–123 2007 128 130 [8] G.F.W. Wang P. Qin J.S. Zhang L.L. Wang G.D. Wei P.F. Zhu R. Kim J. Alloys Compd. 475 2009 452 455 [9] F. Wang Y. Han C.S. Lim Y. Lu J. Wang J. Xu H. Chen C. Zhang M. Hong X. Liu Nature 463 2010 1061 [10] E.Y. Lee M. Nazarov Y.J. Kim J. Electrochem. Soc. 157 2010 J102 J107 [11] R. Kapoor C.S. Friend A. Biswas P.N. Prasad Opt. Lett. 25 2000 338 340 [12] F. Vetrone J.C. Boyer J.A. Capobianco J. Phys. Chem. B 107 2003 1107 1112 [13] Y.Y. Bu S.G. Xiao X.F. Wang W.H. Yuan J.W. Ding J. Lumin. 130 2010 38 44 [14] X.P. Chen Q.Y. Zhang C.H. Yang D.D. Chen C. Zhao Spectrochim. Acta A 74 2009 441 445 [15] F. Vetrone V. Mahalingam J.A. Capobianco Chem. Mater. 21 2009 1847 1856 [16] T.J.B. Hollandm S.A.T. Redfern Mineral. Mag. 61 1997 65 69 [17] C.X. Li J. Yang P.P. Yang H.Z. Lian J. Lin Chem. Mater. 20 2008 4317 4326 [18] K. Nakamoto Infrared and Raman Spectra of Inorganic and Coordination Compounds 1978 Wiley New York p. 227 [19] N. Martin P. Boutinaud R. Mahiou J.-C. Cousseins M. Bouderbala J. Mater. Chem. 9 1999 125 128 [20] A. Mech M. Karbowiak L. Kepiński A. Bednarkiewicz W. Strek J. Alloys Compd. 380 2004 315 318 [21] M. Karbowiak A. Mech A. Bednarkiewicz W. Strek L. Kepinski J. Phys. Chem. Solids 66 2005 1008 1019 [22] J.-C. Boyer L.A. Cuccia J.A. Capobianco Nano Lett. 7 2007 847 852 [23] M.Y. Xie X.N. Peng X.F. Fu J.J. Zhang G.L. Lia X.F. Yu Scripta Mater. 60 2009 190 193 [24] C.M. Zhang Z.Y. Hou R.T. Chai Z.Y. Cheng Z.H. Xu C.X. Li L. Huang J. Lin J. Phys. Chem. C 114 2010 6928 6936 [25] Q.L. Dai H.W. Song X.G. Ren S.Z. Lu G.H. Pan X. Bai B. Dong R.F. Qin X.S. Qu H. Zhang J. Phys. Chem. C 112 2008 19694 19698 [26] H. Guo Y.M. Qiao Opt. Mater. 31 2009 583 589 [27] F. Vetrone J.C. Boyer J.A. Capobianco A. Speghini M. Bettinelli Chem. Mater. 15 2003 2737 2743 [28] J.A. Capobianco F. Vetrone J.C. Boyer A. Speghini M. Bettinelli J. Phys. Chem. B 106 2002 1181 1187 [29] H. Guo N. Dong M. Yin W.P. Zhang L.R. Lou S.D. Xia J. Phys. Chem. B 108 2004 19205 19209 [30] H. Guo Opt. Mater. 29 2007 1840 1843 [31] H. Lin G. Meredith S. Jiang X. Peng T. Luo N. Peyghambarian E.Y. Pun J. Appl. Phys. 93 2003 186 191",
        "keywords": [
            "Co-precipitation technique",
            "Fluoride source",
            "Hydrothermal synthesis",
            "Upconversion"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "WeiHang Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2011
    },
    "7q0eGD4h": {
        "id": "7q0eGD4h",
        "title": "White upconversion emission in Li+/Yb3+/Tm 3+/Er3+-doped Gd6MoO12 phosphors",
        "abstract": "The Yb3+/Er3+/Tm3+-doped Gd 6MoO12 phosphors and Li+/Yb3+/ Er3+/Tm3+-doped Gd6MoO12 phosphors were synthesized by the high-temperature solid-state method. Under 980 nm laser diode excitation, the Gd6MoO12:Li+/Yb 3+/Er3+/Tm3+ phosphors show the white upconversion (UC) emission at the pump power of 200 mW/cm2, which is composed of the blue (1G4→3H6 of Tm3+), green (2H11/2, 4S 3/2→4I15/2 of Er3+), and red (4F9/2→4I15/2 of Er 3+) UC emissions. The calculated CIE color coordinates of Gd 6MoO12:Tm3+/Er3+/Yb3+ phosphors changed from blue area to white area after the Li+ ion doping. Then, the effect of Li+ ions mixing on the emission was analysed. The relative UC mechanisms and properties were also investigated and proposed based on their spectral. The additional mixed Li+ ions enhanced the red and green upconversion emission largely in this phosphor and then formed the white UC emission, which indicated that the Li+ is a promising dopant for tuning white light luminescence in some case. © 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Li+ ions",
            "Rare earths",
            "White-light emission"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Bing Xue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Optics Communications",
        "year": 2013
    },
    "72sCRcDz": {
        "id": "72sCRcDz",
        "title": "Synthesis and luminescence properties of Na2Ba2Si2O7:Eu2+ phosphor",
        "abstract": "Green-emitting phosphor NaBaSiO:Eu has been synthesized by a conventional high-temperature solid-state reaction. The phase structure and luminescence properties are characterized by the X-ray powder diffraction, diffuse reflectance spectra, photoluminescence excitation and emission spectra, temperature-dependent emission spectra, respectively. It can be efficiently excited in the wavelength range of 325–400 nm and consists of a strong broad green band centered at about 501 nm, which is ascribed to 4f6s5d → 4f6s5d transition of Eu. The critical quenching concentration of Eu in the NaBaSiO host is about 0.8 mol % and corresponding quenching behavior is ascribed to be electric dipole–dipole interaction. Furthermore, the phosphor has good thermal stability property, and the activation energy for thermal quenching is calculated as 0.34 eV.",
        "keywords": [
            "Diffuse Reflectance Spectrum",
            "Thermal Quenching",
            "Multipole Interaction",
            "Quenching Behavior",
            "Chromaticity Coordinate"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "dianpeng cui",
                "org": "beijing technology and business university"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            }
        ],
        "venue": "Applied Physics B",
        "year": 2013
    },
    "ohbEQm5b": {
        "id": "ohbEQm5b",
        "title": "Multifunctional materials prepared by means of the surface treatment about crude white mica",
        "abstract": "High purity and luster titanium dioxide-coated mica was prepared by means of multiple liquid-phase deposition on the crystallite surface of mica hosts.The actinicity of the mica titanium pigments coated with ZnO film was reduced through UV absorb spectroscopic analysis.Furthermore,the actinicity of the mica titanium pigments coated with ZnO film and TiO_2 when we calcined it at 850℃ for an hour,was not only reduced but promoted the rutile through XRD action spectrum analysis.Colorful conductive pearlescent pigment was prepared by covering SnO_2-Sb_2O_3 films on the surface of mica titanium.",
        "keywords": [
            "surface coating",
            "mica",
            "pearlescent pigment"
        ],
        "authors": [
            {
                "name": "Guo Mengmeng",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Li Qian",
                "org": "College of Chemical and Environment Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2006
    },
    "iy7MxKTu": {
        "id": "iy7MxKTu",
        "title": "Liquid-phase Synthesis and Optical Properties of β-NaLuF_4:Yb~(3+),Er~(3+) Colloid Particles",
        "abstract": "Oil-dispersible β-NaLuF4:Yb3+,Er3+ colloid particles were synthesized via a facile hydrothermal method in the liquid-phase system containing ethanol-water-oleic acid-sodium oleic acid.The hexagonal phase structure of the sample was characterized by the X-ray diffraction technique.Transmission electron microscopy and high resolution transmission electron microscopy indicate that the β-NaLuF4:Yb3+,Er3+ colloid particle was crystallized in the hexagonal morphology with the size of 10 nm×10 nm×40 nm.Upon 980 nm near-infrared irradiation,the as-prepared particles showed strong emission peak at 543 nm,which corresponded to the 4S3/2-4I15/2 transition of the Er3+ ions.The double-photon emission was assigned to the emitting mechanism.",
        "keywords": [
            "rare earth",
            "functional materials",
            "liquid-phase synthesis",
            "colloid particles"
        ],
        "authors": [
            {
                "name": "ZHOU Wei",
                "org": "School of Science,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "XIAN Jian-bo",
                "org": "School of Science,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "School of Science,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "School of Science,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Fine Chemicals",
        "year": 2011
    },
    "srrCkEs6": {
        "id": "srrCkEs6",
        "title": "Upconversion luminescence of Yb~(3+)/Ho~(3+)/Er~(3+)/Tm~(3+) co-doped KGd(WO_4)_2 powders",
        "abstract": "Different lanthanide ions (Yb3+/Ho3+/Er3+/Tm3+) codoped KGd(WO4)2 phosphors were prepared by high-temperature solid-state reaction. The upconversion luminescence properties of two-ion and three-ion co-doped KGd(WO4)2 phosphors were investigated in detail. The concentration quenching effect of the two-ion co-doped KGd(WO4)2 phosphors was studied, and the optimum concentration of Ho3+, Er3+ and Tm3+ are 2 mol.%, 2 mol.% and 3 mol.%, respectively. The Yb3+/Ho3+/Tm3+ co-doped KGd(WO4)2 sample is the best white upconversion luminescence material among three-ion co-doped KGd(WO4)2 phosphors. The CIE coordinates for the samples were calculated, and chromaticity coordinates were close to white light regions. The upconversion luminescence mechanism of the samples was discussed. The upconver-sion luminescence of Ho3+ and Er3+ was both produced through two-photon process. The emissions of Ho3+ at 546 and 654 nm originated from the transition of Ho3+ (5S2→5I8 and 5F5→5I8), while those of Er3+ at 530 and 551 nm were attributed to the transition of Er3+ (2I11/2→4I15/2 and 4S3/2→ 4I15/2). The upconversion luminescence mechanism of Tm3+ was a three-photon process. The blue emission of Tm3+ was due to the transition of Tm3+ (1G4→3H6).",
        "keywords": [
            "upconversion luminescence",
            "white light phosphor",
            "kgd(wo4)2 powder",
            "rare earths"
        ],
        "authors": [
            {
                "name": "DU Haiyan",
                "org": " College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "LAN Yujing",
                "org": " College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "XIA Zhiguo",
                "org": " School of Materials Sciences and Technology, China University of Geosciences, Beijing , China"
            },
            {
                "name": "SUN Jiayue",
                "org": " College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2010
    },
    "DsGt5VOt": {
        "id": "DsGt5VOt",
        "title": "Upconversion luminescence properties of ZBLAN : Nd3+, Tm3+, Yb3+]",
        "abstract": "The ZBLAN : Nd3+, Tm3+, Yb3+ upconversion materials were prepared by high-temperature solid method. The concentrations of Tm3+ and Yb3+ were 0.01% and 0.3% respectively. The concentration of Nd3+ changed in the range from 0.1% to 2%. The absorption spectrum of ZBLAN : Nd3+, Tm3+, Yb3 in all samples from 300 to 1 000 nm was measured at room temperature. The upconversion emission was observed when excited by 798 nm infrared light. The material samples emitted relatively strong multi-band (the red, blue and green color) visible light. Based on the experiment, the multi-band visible spectral lines were analyzed, and the energy level transition mechanism was given. The blue light results from the transition of 1G4 --> 3 H6 of Tm3+, the green light is from the transition of 2 H7/2 --> 4 I9/2 of Nd3+, and the red light originates from the transition of 2 H11/2 --> I9/2 of Nd3+. The results show that the upconversion mechanism includes excited state absorption, energy transfer, cross relaxation and so on. The energy transfer processes between Nd3+, Tm3+ and Yb3+ ions both forward and backward prove to be the origin of upconversion emissions. The effect of rare earth doping concentration on the energy upconversion efficiency was analyzed, according to the different upconversion light emitting intensity from samples with different Tm3+ mol concentrations. The upconversion luminescence increased with the Nd3+ concentration and got its peak at 1.5%.",
        "keywords": [
            "tm3+ and yb3+:zblan glasses",
            "rare earth ions",
            "upconversion",
            "nd3+",
            "fluorescence spectrum"
        ],
        "authors": [
            {
                "name": "Zhi-Ping Yang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Hai-Yan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jia-Yue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Wei Wang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2009
    },
    "c8kwvGGs": {
        "id": "c8kwvGGs",
        "title": "Research in the influence of polystyrene on cheminescence efficiency",
        "abstract": "Based on the research system composed of Bis(2,4,5-trichloro-6-carbonpentoxyphenyl) oxalate(commonly referred to \"CPPO\") and red fluorescer Rhodamine B,the influence of inhibitor oxalic acid,polymer additive PS and their joint effect are discussed respectively.The results show that systematic cheminescence efficiency is the highest with the combination of oxalic acid and PS,which is justified by the elongated light life and improved light intensity.",
        "keywords": [
            "oxalic acid",
            "cheminescence efficiency",
            "PS",
            "chemluminescence"
        ],
        "authors": [
            {
                "name": "XUE Yan-ju",
                "org": "School of Chemical and Environmental Engineering, Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "School of Chemical and Environmental Engineering, Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "School of Chemical and Environmental Engineering, Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Journal of Functional Materials",
        "year": 2008
    },
    "l4IFhalh": {
        "id": "l4IFhalh",
        "title": "Combustion synthesis and luminescence properties of blue NaBaPO 4:Eu 2+ phosphor",
        "abstract": "The blue-emitting phosphor NaBaPO 4:Eu 2+ was prepared by the combustion method. The phase structure and microstructure of the as-prepared samples were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. Under the excitation wavelength of 360 nm, the emission spectrum exhibited only one blue band centering at 435 nm, which was ascribed to the 4f 65d 1→4f 7 transition on Eu 2+ ions. Compared with the phosphor obtained by solid-state reaction method, the relative emission intensity of sample obtained by combustion method increased slightly. The decay times and the temperature dependence luminescence intensities (25-300°C) were discussed in order to further investigate the potential applications. Furthermore, Eu 2+-doped NaBaPO 4 phosphor showed higher thermally stable luminescence comparable to commercially available Y 3Al 5O 12:Ce 3+ (YAG:Ce 3+) phosphor. All the investigated suggestions that NaBaPO 4:Eu 2+ is a good phosphor candidate applied in white light emitting diode. © 2012 The Chinese Society of Rare Earths.",
        "keywords": [
            "photoluminescence"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2012
    },
    "6KTuT3ZZ": {
        "id": "6KTuT3ZZ",
        "title": "Luminescence of Eu2+ in alkali earth chlorosilicate phosphor and their color-tunable properties",
        "abstract": "Alkali earth chlorosilicate of the types Sr 4− x Mg x Si 3 O 8 Cl 4 :Eu 2+ and Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ have been synthesized from mixtures of SrCO 3 , CaCO 3 , SrCl 2 · 6H 2 O, SiO 2 , MgO, Eu 2 O 3 and proper fluxing agent selected from NH 4 Cl and H 3 BO 3 , which were fired at 900–1000 °C for 2–4 h, and carbon powder was used as a reducing agent. According to the Van Uitert experimental equation, the color-tunable photoluminescence properties and crystal-lattice environment of Eu 2+ in the host lattice have been studied. Depending on the ratio of Sr 2+ and other alkali earth ions (Mg 2+ or Ca 2+ ) in the host, the position and intensity of different luminescence centers are influenced by Eu 2+ located at different chemical environmental sites. Owing to this, it shows from blue-violet (411 nm) to greenish-yellow (565 nm) luminescence under 365nm ultraviolet radiation. Keywords Optical materials Chlorosilicate Color-tunable Spectra Luminescence 1 Introduction Chlorosilicate crystal material is a suitable host lattice for luminescence materials. Alkali earth halide and silicate compound are both effective host as the Eu 2+ luminescence matrices. As the multiplex compound, alkali earth chlorosilicate crystal has lower synthesis temperature and higher physical chemistry stability [1–3] . In the chlorosilicate host, the luminescence of Eu 2+ consists of a 4f 6 5d 1 –4f 7 ( 8 S 7/2 ) broad-band emission, which belongs to electric-dipole allowed transition and has the properties of large absorption of UV light and broad emission range from ultraviolet to infrared light depending on different crystal-lattice environment [4] . In this paper, a series of color-tunable photoluminescence materials having the chemical formula as Sr 4− x Mg x Si 3 O 8 Cl 4 :Eu 2+ ( x = 0, 0.5, 1.0, 1.5) and Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ ( x = 0.2, 0.4, 0.6, 1.0, 1.5, 2.0) are synthesized through the high temperature solid state method. By analyzing the excitation and emission spectra, the luminescence mechanism of Eu 2+ in this kind of host lattice are discussed. And the relationship of material structure with the luminescence properties is also studied. This series of materials are promising to be used for light emitting diodes (LEDs) and will promote the development of the application in luminescence and display fields. 2 Experimental Through the high-temperature solid state synthesis method, a series of powder samples of (Sr, Mg) 4 Si 3 O 8 Cl 4 :Eu 2+ and (Sr, Ca) 4 Si 3 O 8 Cl 4 :Eu 2+ were prepared respectively by firing intimate mixtures of high-purity SrCO 3 (A.R.), CaCO 3 (A.R.), SrCl 2 · 6H 2 O (A.R), SiO 2 (A.R.), MgO(A.R.), Eu 2 O 3 (99.999%) and proper flux selected from NH 4 Cl(A.R) and H 3 BO 3 (A.R). All starting materials were weight in the proper stoichiometries, and mixed in an agate mortar, then placed in corundum crucibles. The samples were fired at 900–1000 °C for 2–4 h, and carbon powder was used as a reducing agent, by which the samples were covered during firing ( Table 1 ). The X-ray diffraction patterns of the samples were recorded by using SHIMADZU model XRD-6000 X-ray powder diffractometer (Cu Kα radiation, 40 kV, 30 mA and a scanning speed 2.0°/min). All excitation and emission spectra were recorded by using HITACHI model F-4500 fluorescence spectrophotometer with a 400 V photomultiplier tube and a 150 W Xe lamp. 3 Results and discussion 3.1 Phase composition of the obtained phosphors JCPDS file 40-0074 supplies the X-ray diffraction data for Sr 4 Si 3 O 8 Cl 4 , and XRD pattern of the Sr 4 Si 3 O 8 Cl 4 :Eu 2+ sample is shown in Fig. 1 . With careful comparison between file 40-0074 of Sr 4 Si 3 O 8 Cl 4 and the sample of Sr 4 Si 3 O 8 Cl 4 :Eu 2+ , the position and intensity of the main peaks are nearly the same. It also indicates that the crystal lattice and basic structure of the Sr 4 Si 3 O 8 Cl 4 host can obtained successfully by the traditional high temperature solid state method. By adding Mg 2+ or Ca 2+ to the host lattice, Sr 4− x Mg x Si 3 O 8 Cl 4 :Eu 2+ and Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ phosphors are synthesized with the increase of amount of the magnesium or calcium which replaced the strontium. 3.2 Luminescence of Eu 2+ in Sr 4 Si 3 O 8 Cl 4 host lattice The excitation spectra of Sr 4 Si 3 O 8 Cl 4 :Eu 2+ show characteristic excitation spectra band of Eu 2+ ion, which is broad in the range from 250 nm to 400 nm. As seen in Fig. 2 , it gives the excitation and emission spectra of Sr 4 Si 3 O 8 Cl 4 :Eu 2+ . Under 365 nm UV light, Sr 4 Si 3 O 8 Cl 4 :Eu 2+ shows broad emission, related to the 5d–4f transition, and gives a strong blue-green luminescence with peak wavelength at 496 nm and FWHM 70 nm. But as shown in Fig. 2 , the emission spectra has some appreciable asymmetry, the possible reason is that the excitation and emission spectra overlap each other. So it results in the self-absorption of the sample’s short wavelength side. Nevertheless, the sample possibly has only one emission center, that is to say that the coordinating environments for all Eu 2+ are the same, thus, the luminescent emission shows only one broad peak [2] . According to the report of Van Uitert [5] , for most divalent and some trivalent rare earth ions in suitable matrices, such as sulfide, oxide, halide and aluminates, the following experiential equation provides a good fit to the emission peak and excitation edge data for Eu 2+ and Ce 3+ . Based on this, the problem about which kind of crystallographic site substituted by Eu 2+ in the Sr 4 Si 3 O 8 Cl 4 host lattice is discussed and testified. (1) E = Q 1 - ( V / 4 ) 1 / V 10 - ( near ) / 80 In the above Eq. (1) , E represents the position of the d-band edge in energy for rare earth ions (cm −1 ), Q is the position in energy for the lower d-band edge for the free ions, value of Q is 34,000 cm −1 for Eu 2+ , V is the valence of the “active” cation, here V = 2. ‘ea’ is the electron affinity of the atoms that form anions, ea is regarded as 2.19 eV in Sr 4 Si 3 O 8 Cl 4 host. n is the number of anions in the immediate shell about this ion, and r is the radius of the host cation replaced by the “active” cation. It is reported that Sr is coordinated by four O atoms and four Cl atoms in the Sr 4 Si 3 O 8 Cl 4 host and the sites of Sr 2+ will substitute by Eu 2+ in the Sr 4 Si 3 O 8 Cl 4 :Eu 2+ phosphor, whichever factor like radius and charge are considered [2] . So the value of coordination number n of Eu 2+ is eight, and the radius of Sr 2+ under this coordination environment is 0.126 nm. Through the above data, it can be calculated that there is only one octa-coordination Sr 2+ sites in the host lattice and the Eu 2+ center that shows blue-green luminescence really comes from octa-coordination Sr 2+ site [6] . 3.3 Luminescence properties of (Sr, Mg) 4 Si 3 O 8 Cl 4 :Eu 2+ phosphor By changing the dopant amount of Mg 2+ ions, a series of powder materials represented by the chemical formula Sr 4 Si 3 O 8 Cl 4 :Eu 2+ , Sr 3.5 Mg 0.5 Si 3 O 8 Cl 4 :Eu 2+ , Sr 3.0 MgSi 3 O 8 Cl 4 :Eu 2+ and Sr 2.5 Mg 1.5 Si 3 O 8 Cl 4 :Eu 2+ were successfully synthesized under the condition of invariable dopant concentration of Eu 2+ in the host lattice. As mentioned above, all the excitation spectra of the materials show characteristic excitation spectra band of Eu 2+ ion, which is broad in the range from 250 nm to 400 nm. The emission spectra of them are shown in Fig. 3 . And Table 2 gives the respective center position of different Sr 4− x Mg x Si 3 O 8 Cl 4 : Eu 2+ phosphors. According to the experimental equation of Van Uitert, the theoretical value of Eu 2+ luminescence center that substituted the octa-coordination Sr 2+ site is 471 nm. So we can conclude that the Eu 2+ center that shows blue-green luminescence really comes from octa-coordination Sr 2+ site, and signed it as Sr (A) site. While considering the emission peak that shows blue-violet luminescence, it arises from the dopant of Mg 2+ in the host lattice, and its emission intensity increases remarkably with the concentration of Mg 2+ increasing as seen from the Fig. 3 . This indicates that the Eu 2+ center that shows blue-violet luminescence here originates from a completely different site substitution from the former, and we can consider it as Sr (B) site. The correlative data can be seen form the emission peak (B) in the Table 2 , which is obviously different from theoretical calculated value of Eu 2+ center occupied octa-coordination Sr 2+ site. From the above spectroscopic analysis, we can conclude that there are two different property cation sites in the host lattice because of the dopant of Mg 2+ . The possible reason is that the large size difference between Mg 2+ and Sr 2+ , and it results in the distortion of host lattice to some certain extent. But simultaneously we notice that the framework of Sr 4 Si 3 O 8 Cl 4 can hardly change completely by the introduction of impurity ions owing to cation replacement. Therefore, the coordination numbers of cation ions whatever Sr (A) site or Sr (B) site are invariably eight as likely as not, and the substitution process can hardly produce other new coordination numbers in the host lattice because of similar physical chemistry properties between Sr 2+ and Mg 2+ . So we consider that the different luminescence peaks are not aroused by the luminescence centers of Eu 2+ located in the sites possessing different coordination numbers, and the two different luminescence centers of Eu 2+ should be ascribed to their respective crystal-lattice environment [6] . 3.4 Luminescence properties of (Sr,Ca) 4 Si 3 O 8 Cl 4 :Eu 2+ phosphor Different from the Eu 2+ luminescence in Sr 4− x Mg x Si 3 O 8 Cl 4 host, the following experimental conclusion indicate that the emission peak of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ change irregularly depending on the ratio of Sr 2+ and Ca 2+ in the host lattice. When the doping amount of calcium ( x ) ranged from 0 to 0.5, the sample shows blue-green emission as seen in Fig. 4 . And the respective center position for the different compositions of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ is listed in Table 3 . Obviously, the spectra properties of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ does not differ largely from Sr 4 Si 3 O 8 Cl 4 :Eu 2+ . Its emission peak does not change to some extent except for the decrease of the luminescence intensity. Considering the small dopant amount of Ca 2+ , similar radius difference and physical chemical property between Ca 2+ and Sr 2+ , it is possible that Ca 2+ ions are embedded in the host lattice of Sr 4 Si 3 O 8 Cl 4 and substitute the Sr 2+ sites partly; finally they form solid dissolved system among definite component range. So Eu 2+ will mainly substitute the octa-coordination Sr 2+ sites, and show blue-green luminescence. It is obvious that the luminescence of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ that x ranged from 0 to 0.5 is similar to the above discussion about Sr 4− x Mg x Si 3 O 8 Cl 4 :Eu 2+ . On the other hand, Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ shows greenish-yellow luminescence when the range of x is between 0.5 and 2. The emission spectra of them are shown in Fig. 5 . The relationships of the main emission peaks and compositions are given in Table 4 . As shown in Fig. 5 and Table 4 , we find that Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ ( x > 0.5) phosphor show obvious emission peak in the long wavelength side, while the emission peak in the short wavelength side become even invisible. But on an energy scale, the emission bands of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ ranging from 0.5 to 2.0 appear to be asymmetric, and each of them can be divided into two Gaussian bands. For example, as seen in Fig. 6 , the emission spectrum of Sr 2 Ca 2 Si 3 O 8 Cl 4 :Eu 2+ is divided into two Gaussian bands with maxima at 467 and 565 nm. We proposed that there are two different emission center in the host lattice of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ . The emission center in the short wavelength side is signed as Eu (A), and Eu (B) is the center in the long wavelength side. Table 5 shows the respective position of Eu (A) and Eu (B) emission centers that obtained from Gaussian fit of different compositive samples of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ ( x > 0.5). Even as the above discussion, the theoretical value of Eu 2+ luminescence center that substituted the octa-coordination Sr 2+ site is 471 nm. And Eu (A) is mostly probably ascribed to Eu 2+ ions that substituted the octa-coordination Sr 2+ sites. Obviously, the measured position of emission peak is the same as the calculated values by Van Uitert experimental equation. Owing to the same reason as the former, the forming of Eu (B) emission can’t be explained by the existing of other coordination number cations in the host lattice. Eu (B) emission is at long wavelengths, which is similar to what has been observed in BaF 2 :Eu 2+ [7] . This is due to the fact that the Eu 2+ emission originated from the formation of an impurity-trapped exciton state. Eu (B) emission center is located in the impurity-trapped exciton state, which is the lowest excited state of this system. The reason is that chlorosilicate compounds have not only the properties of silicate compound, but also that of alkali earth halide. Along with the substantive adding of Ca 2+ , it gradually shortens the distance of M 2+ (Sr 2+ or Ca 2+ ) and halide ions, also including other anion ions in the system, because of the smaller radius of Ca 2+ . At the same time, it also accelerates the formation of impurity-trapped exciton state as the dopant amount of Ca 2+ is beyond 0.5. A model for the luminescence of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ ( x > 0.5) phosphors can be given in terms of configuration coordinate diagrams as shown in Fig. 7 . From it, curve G represents the ground state; and relative to the original localized excited state L, the impurity-trapped exciton state E has lower energy. By the direct UV radiation, the photon located at the ground state G is excited to the localized excited state L, and then relaxed to the impurity-trapped exciton state E in terms of the crossing F. When the optical transition happens between curve E and G, Eu 2+ emission is at long wavelengths and a large Stokes shift is observed [7] . 4 Conclusion Sr 4− x Mg x Si 3 O 8 Cl 4 ( x = 0, 0.5, 1.0, 1.5) and Sr 4− x Ca x Si 3 O 8 Cl 4 ( x = 0.2, 0.4, 0.6, 1.0, 1.5, 2.0) samples were prepared by the high-temperature solid-state reaction. Based on its excitation and emission spectra of Sr 4− x Mg x Si 3 O 8 Cl 4 :Eu 2+ phosphors, the possibilities of two Eu 2+ emission centers is found and the emission peak shifts from blue-green to blue-violet with the increase of amount of the magnesium which replaces the strontium. Depending on the ratio of Sr 2+ and Ca 2+ in the host lattice of Sr 4− x Ca x Si 3 O 8 Cl 4 :Eu 2+ , the intensity of two Eu 2+ emission centers, viz, Eu (A) and Eu(B), changes irregularly and the corresponding relationships with spectra are also discussed. Eu (A) emission center, which has emission peak located at 496 nm, is ascribed to Eu 2+ ions that substituted the octa-coordination Sr 2+ sites, and Eu (B) emission is in the long wavelength range, which is due to the fact that the Eu 2+ emission originated from the formation of an impurity-trapped exciton state. Owing to their color-tunable photoluminescence properties, this insight can be extremely important for understanding the optical properties of rare-earth materials and for guiding the development of materials for applications. Acknowledgements The authors gratefully acknowledge the financial support of the National Natural Science Foundation of China (Grant No. 20476002), the Beijing Natural Science Foundation (Grant No. 2042007), and Science and Technology Development key foundation of Beijing Education Committee (Grant No. KZ20041001107). References [1] H. Wang J. Huang X. Yu J. Lumin. 40–41 1988 893 [2] J. Wang G. Li S. Tian Mater. Res. Bull. 36 2001 2051 [3] S.H.M. Poort H.M. Reijnhoudt H.O.T. Van der Kuip J. Alloy Compd. 241 1996 75 [4] J.L. Sommerdijk A.L.N. Stevels Philips Technol. Rev. 37 1977 221 [5] L.G. Van Uitert J. Lumin. 29 1984 1 [6] Z. Xia J. Sun H. Du J. Rare Earth 22 2004 370 [7] B. Moine C. Pedrini B. Courtois J. Lumin. 50 1991 31",
        "keywords": [
            "Chlorosilicate",
            "Color-tunable",
            "Luminescence",
            "Optical materials",
            "Spectra"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, PR China"
            },
            {
                "name": "Jiayue Sun",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, PR China"
            },
            {
                "name": "Wei Zhou",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, PR China"
            }
        ],
        "venue": "Optical Materials",
        "year": 2006
    },
    "LBopCCuD": {
        "id": "LBopCCuD",
        "title": "Luminescence properties and energy transfer investigations of BaAl 2B 2O 7:Ce 3,Tb 3 phosphors",
        "abstract": "Ce 3 and Tb 3 co-doped BaAl 2B 2O 7 phosphors were synthesized by the solid-state method. X-ray diffraction (XRD) was used to characterize the phase structure. The photoluminescent properties of Ce 3 and Tb 3 co-doped BaAl 2B 2O 7 phosphors were investigated by using the photoluminescence emission and excitation spectra. Under the excitation of near ultraviolet (n-UV) light, BaAl 2B 2O 7:Ce 3,Tb 3 phosphors exhibited blue emission corresponding to the f-d transition of Ce 3 ions and green emission bands corresponding to the f-f transition of Tb 3 ions, respectively. Effective energy transfer occurred from Ce 3 to Tb 3 in BaAl 2B 2O 7 host due to the observed spectra overlap between the emission spectrum of Ce 3 ion and the excitation spectrum of Tb 3 ion. The energy transfer efficiency from Ce 3 ion to Tb 3 ion was also calculated to be 71%. Furthermore, the concentration quenching and critical distance of BaAl 2B 2O 7:Ce 3,Tb 3 phosphors were also discussed. The energy transfer from Ce 3 to Tb 3 in BaAl 2B 2O 7 host was demonstrated to be resonant type via a dipole-dipole interaction mechanism with the energy transfer critical distance of 16.13 Å. © 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Energy transfer",
            "Optical materials",
            "Phosphor",
            "White LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jinli Lai",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2012
    },
    "mXX5KpiH": {
        "id": "mXX5KpiH",
        "title": "Synthesis and fluorescence of Eu(Ⅲ) ternary complexes with aromatic carboxylic acid",
        "abstract": "The four standard Eu(Ⅲ)organic ternary complexes which used benzoic acid(BA)、o-phthalic acid(o-Phth)、anthranilic acid(o-Amino)、salicylic acid(Sal)as a first ligand to coordinate with Eu(Ⅲ)ion while o-phenanthroline(Phen)was used as the second ligand were synthesized by solution precipitation.The four complexes were detected by elementary analysis、IR、UV and fluorescence spectra which could confirm the structure of the complexes and study their photoluminescence characteristic property to compare with them.The effect of the structure of the first ligand on the photoluminescence of the complexes was discussed,and found some valuable red highlighter organic fluorescence materials.",
        "keywords": [
            "aromatic carboxylic acid",
            "rare earth",
            "Eu(Ⅲ)ternary complex",
            "photoluminescence"
        ],
        "authors": [
            {
                "name": "Zhang Quanping",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2007
    },
    "bxIFkTpg": {
        "id": "bxIFkTpg",
        "title": "The Examination Method and Application of the Pyruvic Acid and Pyruvate",
        "abstract": "The pyruvic acid and the series product have got the extensive use in industry and science researches of chemical engineering, living turn, the medicine of system and agriculture use chemicals etc. The pure degree of the series product, contain the deal, miscellaneous quality of The pyruvic acid and pyruvate ,which are the index signs have something to do with synthesizing method, the different and applied path also has got the different request to these index signs.This text overviews the examination method of quantity index sign for the pyruvic acid and its series products and the applied present condition of pyruvic acid and the series products.",
        "keywords": [
            "Pyruvate",
            "Application",
            "Examination method",
            "Pyruvic Acid"
        ],
        "authors": [
            {
                "name": "Caixia Liu",
                "org": "College of Chemistry and Environment Engineering,Beijing Technology and Business University, Beijing ,China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Environment Engineering,Beijing Technology and Business University, Beijing ,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "College of Chemistry and Environment Engineering,Beijing Technology and Business University, Beijing ,China"
            },
            {
                "name": "Ning Li",
                "org": "Beijing Ganghua Auxiliary Ltd.Co.Beijing ,China"
            }
        ],
        "venue": "Life Science Instruments",
        "year": 2006
    },
    "RIn6nP8Q": {
        "id": "RIn6nP8Q",
        "title": "Synthesis and upconversion luminescence properties of Yb3+/Er3+ codoped BaGd2(MoO4)4 powder",
        "abstract": "Synthesis and upconversion luminescence properties of the new BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphor were reported in this paper. The phosphor powder was obtained by the traditional high temperature solid-state method, and its phase structure was characterized by the XRD pattern. Based on the upconversion luminescence properties studies, it is found that, under 980 nm semiconductor laser excitation, BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphor exhibits intense green upconversion luminescence, which is ascribed to 2 H 11/2 → 4 I 15/2 and 4 S 3/2 → 4 I 15/2 transition of Er 3+ . While the observed much weaker red emission is due to the non-radiative relaxation process of 4 S 3/2 → 4 F 9/2 and 4 F 9/2 → 4 I 15/2 transition originating from the same Er 3+ . The concentration quenching effects for both Yb 3+ and Er 3+ were found, and the optimum doping concentrations of 0.5 mol% Yb 3+ and 0.08 mol% Er 3+ in the new BaGd 2 (MoO 4 ) 4 Gd 3+ host were established. Keywords A. Optical materials C. X-ray diffraction D. Optical properties 1 Introduction In recent years, much attention has been paid to the research on rare earth ion doped upconversion luminescence materials due to their application in the field of high power laser diodes. Moreover, they have found applications in many advanced technology fields, such as coherent laser light sources [1] , three-dimensional display [2] , anti-counterfeiting [3] , bioassay [4] , and so on. The double molybdate and tungstate crystals with general formula MRe(XO 4 ) 2 (M = Li, Na, K; X = W, Mo) have been reported as good host materials for solid-state lasers [5,6] . The crystallographic structures of these compounds belong to the scheelite structure of CaWO 4 [7] . Therefore, the luminescence properties of these compounds, such as Nd 3+ :NaLa(MoO 4 ) 2 [8] , Nd 3+ :KLa(MoO 4 ) 2 [9] , Nd 3+ :NaGd(MoO 4 ) 2 [10] and Ho 3+ ,Yb 3+ :KLa(WO 4 ) 2 [11] have been widely studied as the excellent laser materials. In this paper, the selected BaGd 2 (MoO 4 ) 4 compound belongs to a member of double barium lanthanide molybdates BaLn 2 (MoO 4 ) 4 (Ln = Y, La-Lu) [12,13] , and it may be suitable host material for designing the new upconversion luminescence materials. Therefore, the synthesis and upconversion luminescence properties investigation on Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 powder were reported, and the possible upconversion luminescence mechanism is also discussed. 2 Experimental Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 powder samples were prepared by the traditional high-temperature solid-state reaction. The starting materials were BaCO 3 (A.R.), MoO 3 (A.R.), Gd 2 O 3 (99.99%), Yb 2 O 3 (99.99%), Er 2 O 3 (99.99%). The mixture ratio of the reactants was as follows: (1 − x − y ) Gd 2 O 3 + BaCO 3 + 4MoO 3 + x Yb 2 O 3 + y Er 2 O 3 ( x = 0.2, 0.25, 0.3 and 0.35; y = 0.03, 0.04, 0.05 and 0.06). The weighed raw materials were thoroughly mixed in an agate mortar and then placed in a corundum crucible with a lid. Then, the samples were sintered at 1000 °C for 4 h in air. The phase structure of the as-synthesized Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 powders were determined by X-ray powder diffraction spectroscopy (XRD, using a Shimadzu XRD-6000) operating at Cu Kα radiation, 40 kV, 30 mA, and a scan speed of 2.0° (2 θ )/min. The upconversion luminescence spectra were recorded on a Hitachi F-4500 spectrophotometer equipped with an external power-controllable 980 nm semiconductor laser (Beijing Viasho Technology Company, China) as the excitation source, which is connected with an optic fiber accessory. 3 Result and discussion We have carefully prepared our samples and checked their phase structures. As seen in Fig. 1 , it shows the XRD patterns of the pure BaGd 2 (MoO 4 ) 4 (a) and Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 phosphor powder (b), and the JCPDS Card No. 36-0192 (c). By careful comparison among the given XRD patterns, their positions and intensities of the main peaks are nearly the same. It indicates that the crystal structure of the as-synthesized pure BaGd 2 (MoO 4 ) 4 and Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 phosphor powder are in good agreement with the standard value from the JCPDS files of BaGd 2 (MoO 4 ) 4 , which means that the crystal lattice and basic structure of the BaGd 2 (MoO 4 ) 4 host can be obtained successfully by the high-temperature solid-state method. Further, it also testifies that the crystal structure of BaGd 2 (MoO 4 ) 4 had no obvious change after codoping Yb 3+ and Er 3+ ions. Under 980 nm semiconductor laser excitation, the upconversion luminescence properties of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ with different doping concentration of Yb 3+ and Er 3+ are comparatively investigated in detail. Fig. 2 gives the upconversion luminescence spectra of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphor for different Yb 3+ concentration and invariable Er 3+ concentration (0.06 mol%). As seen in Fig. 2 , two peaks at 532 nm and 553 nm of intense green emissions attributed to the transition emission of Er 3+ ( 2 H 11/2 → 4 I 15/2 and 4 S 3/2 → 4 I 15/2 ) are observed. As seen in the inset of Fig. 2 , it shows the enlarged spectra in the red emission region. The much weaker red emission at 656 nm due to the transition 4 F 9/2 → 4 I 15/2 of Er 3+ can be also seen detected by the instrument, but not observed by the naked eye. With increasing Yb 3+ concentration, the emission intensity increases, maximizes at 0.5 mol% Yb 3+ concentration, and then decreases. It also indicates that the optimum Yb 3+ concentration should be 0.5 mol%. Similarly, as seen in Fig. 3 , it shows the upconversion luminescence spectra of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphor under 980 nm semiconductor laser excitation for different Er 3+ concentration and invariable Yb 3+ concentration (0.5 mol%). The same strong green emission peaks at 532 nm and 553 nm are observed, and concentration dependence of emission intensities is also seen in Fig. 3 . With increasing Er 3+ concentration, the emission intensity increases, maximizes at 0.08 mol% Er 3+ concentration, and then decreases. Accordingly, the variation of red emission region (from 640 nm to 680 nm) agree with the variation tendency former green emission peaks, as given in the inset of Fig. 3 . It further indicates that the optimum Er 3+ concentration should be 0.08 mol%. Therefore, the optimum doping concentrations 0.5 mol% Yb 3+ and 0.08 mol% Er 3+ in the new BaGd 2 (MoO 4 ) 4 Gd 3+ host are established, and a concentration quench effect extends beyond the given region. Upconversion visible emissions are produced through multiple process including ground-state absorption (GSA) and energy transfer (ET). For Yb 3+ /Er 3+ codoped upconversion phosphors, Yb 3+ ion is usually used as a sensitizing ion to increase the upconversion luminescence intensities of the Er 3+ ion, due to the energy matching of the gap (between 2 F 7/2 and 2 F 5/2 ) of Yb 3+ [5] . The possible green upconversion luminescence mechanism is shown in Fig. 4 . A Yb 3+ ion is excited by a 980 nm photon from ground state ( 2 F 7/2 ) to the excited-state ( 2 F 5/2 ) through GSA process, and then transfers the energy to a Er 3+ ion and promotes it from 4 I 15/2 to 4 I 11/2 . Another Yb 3+ ion at 2 F 5/2 level continuously transfers the energy to the excited Er 3+ ion, then the Er 3+ ion transits to a higher level at 4 F 7/2 . The populated level 4 F 7/2 decays non-radiatively to 2 H 11/2 and 4 S 3/2 , finally produces green emissions at 532 nm and 553 nm with a radiative transition to ground state 4 I 15/2 , respectively. It can be concluded that the occurrence of green upconversion luminescence can be attributed to a two-photon process. As seen in the spectra diagram of Figs. 2 and 3 , the red emission of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ is much weaker than the green one. It is so weak that it can hardly be observed from the upconversion luminescence spectra except for the enlarged spectra profiles. The possible explanation is based on the following fact that the red light is produced through the non-radiative relaxation 4 S 3/2 → 4 F 9/2 and the transition 4 F 9/2 → 4 I 15/2 . In this case, the intensities of red upconversion luminescence would be much lower. Further, in order to understand the involved mechanism, the dependence of upconversion luminescence intensity upon the pump power of laser diode is given in Fig. 5 . The relationship between them can be approximately expressed as follows: I out − ( I exc ) n , where n is the number of infrared photons absorbed for emitting a visible photon. In the double-log coordinate, the slope of I out − I exc indicates the value of n , which is used for the deduction of the possible upconversion luminescence process. As given in Fig. 5 , the values of n for green emissions at 532 nm and 553 nm are 1.77 and 1.74, respectively, while that of red emission at 656 nm is 0.69. The results indicate that green emission originated from a two photon process, and the weak red emission should come from the non-radiative relaxation of 4 S 3/2 → 4 F 9/2 . 4 Conclusion A new green upconversion luminescence phosphor powder BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ has been synthesized by high-temperature solid-state method. The pure phase structure of the phosphor is characterized by XRD. It can be observed in the upconversion spectra of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ that the red emission is much weaker than that of green one. The green emission is a two photon processes, while the red light is due to the non-radiative relaxation of Er 3+ ( 4 S 3/2 ) → Er 3+ ( 4 F 9/2 ) and the transition Er 3+ ( 4 F 9/2 ) → Er 3+ ( 4 I 15/2 ). The concentration quenching effects for both Yb 3+ and Er 3+ were found, and the optimum doping concentration of 0.5 mol% Yb 3+ and 0.08 mol% Er 3+ in the new BaGd 2 (MoO 4 ) 4 host are established. Acknowledgements This present work was supported by the National Natural Science Foundations of China (No. 20876002), the Beijing Natural Science Foundation (Nos. 2091002 and 2082009), and Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality. References [1] T. Sandrock H. Scheife E. Heumann G. Huber Opt. Lett. 22 1997 1185 [2] E. Dowing L. Hesselink J. Ralston R. Macfarlane Science 273 1996 1185 [3] Y.L. Cao Laser Infrared 31 2001 190 (in Chinese) [4] C.G. Morgan S. Dad A.C. Mitchell J. Alloys Compd. 451 2008 526 [5] A.A. Kaminskii Laser Crystals: Their Physics and Properties 2nd ed. Springer Ser. Opt. Sci. vol. 14 1990 Springer Berlin, Heidelberg [6] A.A. Kaminskii N.R. Agamalyan L.P. Kozeeva V.F. Nesterenko A.A. Pavlyuk Phys. Stat. Sol. (a) 75 1983 K1 [7] D. Zhao Z.B. Lin G.F. Wang J. Struct. Chem. 26 2007 328 [8] S.B. Stevens C.A. Morrison T.H. Allik A.L. Rheingold B.S. Haggerty Phys. Rev. B 43 1991 7386 [9] E. Cavalli E. Zannoni C. Mucchino V. Carozzo A. Toncelli M. Tonelli Opt. Soc. Am. B 16 1999 1958 [10] X.Z. Li G.F. Wang J. Struct. Chem. 25 2006 392 [11] Z.L. Zhu Y.F. Wu H. Lin L. Chen L.C. Zhao J.H. Liu J. Chin. Ceram. Soc. 36 2008 1074 [12] A.A. Maier N.A. Croshenko T.P. Balakireva A.N. Egorova M.V. Provotorov R.P. Ozerov Kristallografiya 24 1979 973 [13] I.I. Kiseleva M.I. Sirota R.P. Ozerov T.P. Balakireva A.A. Maier Kristallografiya 24 1979 1277",
        "keywords": [
            "a. optical materials",
            "c. x-ray diffraction",
            "d. optical properties"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China"
            },
            {
                "name": "Yujing Lan",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "School of Materials Sciences and Technology, China University of Geosciences, Beijing 100083, China"
            },
            {
                "name": "Jiayue Sun",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2009
    },
    "ZXH7fphi": {
        "id": "ZXH7fphi",
        "title": "Hydrothermal reaction of TiO_2 nanobelts under the condition of strong base",
        "abstract": "TiO2 nanobelts were treated in different concentration of NaOH aqueous solution under the hydrothermal condition of different reaction time and temperature,and the structures and morphologies of the various products were further investigated.The XRD and SEM measurement results showed that the layered titanate nanobelts can be easily prepared from the TiO2 nanobelts treated with strong base solution under hydrothermal condition,whereas the reaction conditions including NaOH aqueous concentration,reaction time and temperature hardly influence on the morphology of the products.",
        "keywords": [
            "TiO2 nanobelt",
            "hydrothermal reaction",
            "titanate nanobelt"
        ],
        "authors": [
            {
                "name": "Liu Yang",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Jin Shurui",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Ji Tianhao",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2010
    },
    "u7CxujWp": {
        "id": "u7CxujWp",
        "title": "Near-infrared downconversion in Eu2+ and Pr3+ co-doped KSrPO4 phosphor",
        "abstract": "A novel near-infrared (NIR) downconversion (DC) phosphor KSrPO4:Eu2+, Pr3+ is synthesized by the conventional high temperature solid-state reaction. The Eu2+ acts as an efficient sensitizer for Pr3+ in the KSrPO4 host. With broadband near-ultraviolet light excitation induced by the 4f -> 5d transition of Eu2+, the characteristic NIR emission of Pr3+, peaking at 974 nm and 1019 nm due to P-3(0)->(1)G(4) and (1)G(4)-> H-3(4) transitions, is generated as a result of the energy transfer from Eu2+ to Pr3+. The luminescence spectra in both the visible and the NIR regions and the decay lifetime curves of Eu2+ prove the energy transfer from Eu2+ to Pr3+. This Eu2+ and Pr3+ co-doped KSrPO4 phosphor may be a promising candidate to modify the spectral mismatch behavior of crystalline solar cells and sunlight.",
        "keywords": [
            "optical properties",
            "cooperative energy transfer",
            "downconversion"
        ],
        "authors": [
            {
                "name": "sun jiayue",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "sun yining",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "zhu jicheng",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "zeng junhui",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "du haiyan",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "CHINESE PHYSICS B",
        "year": 2013
    },
    "GCCuW0t2": {
        "id": "GCCuW0t2",
        "title": "Preparation and up-conversion fluorescence of rare earth (Er3+ or Yb3+/Er3+)-doped TiO2 nanobelts",
        "abstract": "Anatase TiO 2 nanobelts doped with Er 3+ or Yb 3+ /Er 3+ cations were simply synthesized using two-step preparation proceedings of ion-exchange and hydrothermal treatment, and their upconversion emissions were also investigated. SEM images of TiO 2 nanobelts (NBs) doped with Er 3+ (the left) and codoped with Yb 3+ /Er 3+ (the right).",
        "keywords": [
            "Hydrothermal",
            "Rare earth doping",
            "Up-conversion",
            "TiO 2 nanobelts"
        ],
        "authors": [
            {
                "name": "Tianhao Ji",
                "org": ""
            },
            {
                "name": "Yang Liu",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China"
            },
            {
                "name": "Hui Zhao",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China"
            },
            {
                "name": "Jiayue Sun",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China"
            },
            {
                "name": "Guanglu Ge",
                "org": "National Center for Nanoscience and Technology, Beijing 100190, China"
            }
        ],
        "venue": "Journal of Solid State Chemistry",
        "year": 2010
    },
    "7PWbr7BC": {
        "id": "7PWbr7BC",
        "title": "Synthesis and two-color emission properties of BaGd 2(MoO 4) 4:Eu 3+,Er 3+,Yb 3+ phosphors",
        "abstract": "Eu 3+, Er 3+ and Yb 3+ co-doped BaGd 2(MoO 4) 4 two-color emission phosphor was synthesized by the high temperature solid-state method. The structure of the sample was characterized by XRD, and its luminescence properties were investigated in detail. Under the excitation of 395 nm ultraviolet light, the BaGd 2(MoO 4) 4:Eu 3+,Er 3+,Yb 3+ phosphor emitted an intense red light at 595 and 614 nm, which can be attributed to 5D 0 → 7F 1 and 5D 0 → 7F 2 transitions of Eu 3+, respectively. The phosphor will also show bright green light under 980 nm infrared light excitation. The green emission peaks centred at 529 and 552 nm, were attributed to 4H 11/2 → 4I 15/2 and 4S 3/2 → 4I 15/2 transitions of Er 3+, respectively. It indicated that the two-color emission can be achieved from the same BaGd 2(MoO 4) 4:Eu 3+,Er 3+,Yb 3+ host system based on the different pumping source, 395 nm UV light and 980 nm infrared light, respectively. The obtained results showed that this kind of phosphor may be potential in the field of multi-color fluorescence imaging and anti-counterfeiting. © 2011 Published by Elsevier Ltd.",
        "keywords": [
            "a. optical materials",
            "c. x-ray diffraction",
            "d. optical properties"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Wei Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "WeiHang Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2012
    },
    "PPrRRekW": {
        "id": "PPrRRekW",
        "title": "Research and development of rare earth pigment",
        "abstract": "Special optical property of rare earth was introduced.The application of optical property of rare earth in the pigment industry was briefly reviewed.Optical variable pigment that treated with rare earth compound as a promising pigment was proposed.",
        "keywords": [
            "rare earth",
            "optical variation",
            "optical property",
            "pigment"
        ],
        "authors": [
            {
                "name": "Zhang Hua",
                "org": "College of Chemistry and Environment Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemistry and Environment Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "College of Chemistry and Environment Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2007
    },
    "pleHq3EO": {
        "id": "pleHq3EO",
        "title": "Preparation and characterization of upconversion nanocomposite for β-NaYF4:Yb3+,Er3+-supported TiO2 nanobelts",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "j i tianhao",
                "org": ""
            },
            {
                "name": "fang yang",
                "org": ""
            },
            {
                "name": "d u haiyan",
                "org": ""
            },
            {
                "name": "hong guo",
                "org": ""
            },
            {
                "name": "jianshi yang",
                "org": ""
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2010
    },
    "2M2179Pp": {
        "id": "2M2179Pp",
        "title": "Hydrothermal synthesis and the enhanced blue upconversion luminescence of NaYF 4 :Nd 3+ ,Tm 3+ ,Yb 3+",
        "abstract": "",
        "keywords": [
            "upconversion",
            "x ray diffraction",
            "energy transfer",
            "luminescence"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "weihang zhang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "zhiping yang",
                "org": ""
            }
        ],
        "venue": "Infrared Physics & Technology",
        "year": 2010
    },
    "5BWzDmag": {
        "id": "5BWzDmag",
        "title": "Study on Synthesis of Bis(6-butoxycarbonyl-2,4-dichlorophenyl) oxalate Ester and Its Red Emission Chemiluminescence System",
        "abstract": "The intermediate compound butyl 3,5-dichlorosalicylate ester was synthesized.The effects of catalyst and solvent on synthesis were studied.The yield was 98%.Bis(6-butoxycarbonyl-2,4-dichlorophenyl) oxalate ester as an energy source was synthesized and confirmed.The yield was 60%.Various factors affecting the light life and the light intensity of the chemiluminescence system such as peroxyoxalate ester,fluorescence agent, catalyst,oxidant and solvent were also investigated.The optimum formulation was obtained,and the system chemiluminescence life time was 6 h.",
        "keywords": [
            "5-dichlorosalicylate ester",
            "chemiluminescence",
            "4-dichlorophenyl)oxalate ester",
            "chemiluminescence system",
            "synthesis",
            "bis(6-butoxycarbonyl-2",
            "butyl 3"
        ],
        "authors": [
            {
                "name": "XU Min",
                "org": "Chemical and Environmental Engineering College,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Chemical and Environmental Engineering College,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "Chemical and Environmental Engineering College,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Chemical World",
        "year": 2007
    },
    "xLxbZSng": {
        "id": "xLxbZSng",
        "title": "Synthesis and luminescence properties of novel Y 2 Si 4 N 6 C:Sm 3+ carbonitride phosphor",
        "abstract": "",
        "keywords": [
            "luminescence"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "junhui zeng",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "jicheng zhu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "1zZLURNs": {
        "id": "1zZLURNs",
        "title": "Luminescent properties and energy transfer of Ce 3,Tb 3 co-doped NaBaPO 4 phosphor",
        "abstract": "Ce 3 and Tb 3 co-doped NaBaPO 4 phosphors were prepared by a conventional solid-state reaction. The phase structure and luminescence properties of the as-prepared phosphor samples were characterized by using powder X-ray diffraction (XRD), reflection spectra, photoluminescence excitation and emission spectra, decay time, respectively. Effective energy transfer occurs from Ce 3 to Tb 3 in NaBaPO 4 host due to the observed spectral overlap between the emission band of Ce 3 and the excitation band of Tb 3, and the obvious emission bands (354 nm, 489 nm and 542 nm) were ascribed to Ce 3 and Tb 3 ions emission, respectively. We have also shown that the energy transfer from Ce 3 and Tb 3 in NaBaPO 4 host was demonstrated to be resonant type via a dipole-dipole interaction mechanism with the energy transfer critical distance of 1.67 nm. © 2011 The Electrochemical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of the Electrochemical Society",
        "year": 2011
    },
    "qPPUtQ62": {
        "id": "qPPUtQ62",
        "title": "Luminescent Properties and Energy Transfer of Ce3+,Tb3+ Co-Doped NaBaPO4 Phosphor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "xiangyan zhang",
                "org": "beijing technology and business university"
            },
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            }
        ],
        "venue": "Journal of The Electrochemical Society",
        "year": 2011
    },
    "m3tucoQd": {
        "id": "m3tucoQd",
        "title": "Preparation and visible-light photocatalysis of MS(M=Cd or Zn) nanoparticle-supported TiO2 nanowires",
        "abstract": "High-temperature-stable hexagonal CdS or low-temperature-stable cube ZnS nanoparticles supported anatase TiO2 nanowires were prepared using the precursors layered titanate nanowires, CdCl2 or ZnSO4 and thioacetamide by two-step hydrothermal synthesis process. Titanate nanowires with Cd2+ or Zn2+ cations were first obtained using layered titanate nanowires and CdCl2 or ZnSO4 under the hydrothermal condition; then, the products were treated in the diluted thioacetamide solution at 160°C to prepare CdS-or ZnS-supported TiO2 nanowires. After they were immersed into diluted HCl solution, the CdS or ZnS nanoparticles on TiO2 nanowires could still be observed. The visible-light photocatalytic measurement results for the acid-treated samples, pure TiO2 nanowires and commercial P25 demonstrate that the photocatalysis of TiO2 nanowires with CdS is the highest.",
        "keywords": [
            "CdS nanoparticles",
            "Composite nanowires",
            "Hydrothermal synthesis",
            "TiO2 nanowires",
            "ZnS nanoparticles"
        ],
        "authors": [
            {
                "name": "Tianhao Ji",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Miao Tian",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Guanglu Ge",
                "org": "National Center for Nanoscience and Technology Beijing(National Center for Nanoscience and Technology,National Center for Nanoscience and Nanotechnology),Beijing,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2010
    },
    "dsjwOMm3": {
        "id": "dsjwOMm3",
        "title": "Luminescence properties and energy transfer investigations of BaAl2B2O7:Ce3+,Tb3+ phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "jinli lai",
                "org": ""
            },
            {
                "name": "zhiguo xia",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "jiayue sun",
                "org": ""
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2012
    },
    "B0pCvKgC": {
        "id": "B0pCvKgC",
        "title": "Preparation and characterization of Co-MoO_3 Nanobelts",
        "abstract": "Co-embedded α-MoO3(Co-MoO3) nanobelts were prepared using precursors CoCl2 and HxMoO3 nanobelts by hydrothermal and ion-exchangeable proceeding.The measurement results show that the crystalline phase and morphology of Co-MoO3 have not been changed yet after the Co2+ cations were embedded into the space between the two nearest-neighbored layers;by comparison of the FTIR spectra and XRD patterns for the two samples with and without the Co2+ cations,it can be also demonstrated that the H+ ions between the layers not only exist interaction with the oxygen atoms in MoO6,but also form new crystalline plane.",
        "keywords": [
            "hydrothermal preparation",
            "Co-MoO_3 nanobelts",
            "ion-exchange"
        ],
        "authors": [
            {
                "name": "JI Tian-hao",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "YANG Yi-xiong",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Journal of Functional Materials",
        "year": 2009
    },
    "Z7I4yvHo": {
        "id": "Z7I4yvHo",
        "title": "Size and shape controllable synthesis of oil-dispersible BaYF 5:Yb3+/Er3+ upconversion fluorescent nanocrystals",
        "abstract": "Well-crystallized and regular-shaped BaYF5:Yb 3+/Er3+ upconversion (UC) fluorescent nanocrystals (NCs) were synthesized in a modified water-ethanol-oleic acid system. The size and shape of the NCs were controlled by adjusting the amount of NaOH, reaction temperature and time. Well oil-dispersible NCs exhibited bright UC fluorescence under the 980 nm excitation. Furthermore, a systematic study on the photoluminescence of Yb3+/Er3+-doped BaYF5 samples with different size and shapes indicated that the optical properties of products were strongly dependent on their size, and the configuration of nanocrystals were found to sensibly affect the optical properties of the products. Great enhancement of the green emission intensity was observed with increasing crystalline size. It was found that the crystalline and surface effects could be responsible for the observation and this behavior was attributed to a change of conditions and the quenching effect of the organic ligands. © 2010 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Chemical synthesis",
            "Luminescence",
            "Optical materials"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianbo B. Xian",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2011
    },
    "IvhCkIjp": {
        "id": "IvhCkIjp",
        "title": "White upconversion emission in Li + /Yb 3+ /Tm 3+ /Er 3+ -doped Gd 6 MoO 12 phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "bing xue",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Optics Communications",
        "year": 2013
    },
    "KnL9OPbV": {
        "id": "KnL9OPbV",
        "title": "Synthesis and luminescence properties of novel Y2Si4N6C:Sm3+ carbonitride phosphor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "junhui zeng",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "jicheng zhu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "2iK5rei9": {
        "id": "2iK5rei9",
        "title": "Photostimulated luminescence studies of electron trapping materials SrS:Eu2+,RE (RE= Dy3+,Yb3+,Pr 3+,Ho3+,Tm3+)",
        "abstract": "Trivalent rare-earth ions, Dy3+, Yb3+, Pr 3+, Ho3+, Tm3+, have been investigated as the co-doped auxiliary sensitizer for the electron trapping materials SrS:Eu 2+ in order to enhance the fluorescence properties. It is found that Dy3+ and Ho3+ has the optimum photoluminescence stimulated luminescence (PSL) effect among the selected trivalent rare-earth ions. All the SrS: Eu2+ samples coped by different trivalent rare-earth ions can be stimulated by 980 nm laser after exposing to the conventional sun light, and they emit PSL with the peak located at 615 nm. The present research also indicates that some co-doped rare earth ions can increase fluorescence intensities of the traditional electron trapping materials SrS: Eu2+. © (2011) Trans Tech Publications.",
        "keywords": [
            "Electron trapping effect",
            "Optical storage materials",
            "Photo stimulated luminescence"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhenxing Liu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "j6ZN25zA": {
        "id": "j6ZN25zA",
        "title": "Luminescence properties of a new red emitting Eu3+-doped alkaline-earth fluoborate phosphor: BaCa(1-2x)BO 3F:xEu3+, xM+ (M=Li, Na, K)",
        "abstract": "A series of new red-emitting BaCa1-2xBO3F:xEu 3+, xM+ (M=Li, Na, K) phosphors were synthesized by the solid-reaction method. X-ray diffraction (XRD), diffuse reflection (UV-vis) and photoluminescence spectra were utilized to characterize the crystallization process, structure and luminescence properties of the as-synthesized phosphors. The XRD results indicated that the sample began to crystallize at 800 °C, and single-phase BaCaBO3F was fully obtained after annealing at 1000 °C. The charge compensated behaviors were investigated in this paper by considering different cations like Li+, Na+ and K + acting as the charge compensator. The as-prepared phosphors had better emission properties, and the two characteristic emission lines peaking at 590 and 615 nm could be obtained upon 394, 463 and 532 nm excitation with the chromaticity coordinates of (0.596, 0.391), which were due to 5D 0-7F1 and 5D0- 7F2 transitions of Eu3+ ions. Further, the concentration quenching and corresponding luminescence mechanisms of BaCa 1-2xBO3F:xEu3+, xNa+ phosphors were also discussed. © 2011 The Chinese Society of Rare Earths.",
        "keywords": [
            "charge compensator",
            "fluoborate",
            "phosphor",
            "rare earths"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jinli Lai",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianfeng Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2011
    },
    "ugp3EjI0": {
        "id": "ugp3EjI0",
        "title": "NIR-to-blue, green, orange and white up-conversion luminescence in Yb 3+ /Tm 3+ /Er 3+ /Ho 3+ -doped Na 0.5 Gd 0.5 WO 4 nanocrystals",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiguo xia",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "jiayue sun",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "6bRoE7bk": {
        "id": "6bRoE7bk",
        "title": "Synthesis and luminescence properties of Gd6MoO 12:Yb3+, Er3+ phosphor with enhanced photoluminescence by Li+ doping",
        "abstract": "Yb3+/Er3+ co-doped Gd6MoO12 and Yb3+/Er3+/Li+ tri-doped Gd6MoO 12 phosphors were prepared by adjusting the annealing temperature via the high temperature solid-state method. Under the excitation of 980 nm semiconductor, the upconversion luminescence properties were investigated and discussed. In the experimental process, we get the optimum Yb3+ concentration and the concentration quench effect will happen while the concentration extends the given region. According to the Yb3+ concentration quenching effects, the critical distance between Yb3+ ions had been calculated. The measured UC luminescence exhibited a strong red emission near 660 nm and green emission at 530 nm and 550 nm, which are due to the transitions of Er3+(4F9/2, 2H11/2, 4S3/2) → Er 3+(4I15/2). Then the effect of excitation power density in different regions on the upconversion mechanisms was investigated and the calculated results demonstrate that the green and red upconversion is a two-photon process. A possible mechanism was discussed. After Li+ ions mixing, the upconversion emission enhanced largely, and the optimum Li + concentration was obtained while fixed the Yb3+ and Er3+ on the above optimum concentration. This enhancement owns to the decrease of the local symmetry around Er3+ after Li+ ions doping into the system. This result indicates that Li+ is a promising candidate for improving luminescence in some case. © 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Phosphor",
            "Rare earth",
            "Upconversion luminescence"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Bing Xue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Infrared Physics and Technology",
        "year": 2013
    },
    "ZJh0KStw": {
        "id": "ZJh0KStw",
        "title": "Luminescence properties and energy transfer investigations of Sr 3 Gd(PO 4 ) 3 :Ce 3+ ,Tb 3+ phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "junhuizeng",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Physics and Chemistry of Solids",
        "year": 2013
    },
    "84DPD0mp": {
        "id": "84DPD0mp",
        "title": "Blue upconversion luminescence from phosphor Tm3+/Yb3+ co-doped Gd2Mo3O9",
        "abstract": "The upconversion (UC) luminescence properties of phosphor Tm3+/Yb3+ co-doped Gd2Mo3O9 were investigated in detail. Tm3+/Yb3+ co-doped Gd2Mo3O9 was prepared by solid-state reaction method using Na2CO3 as flux and characterized by powder X-ray diffiactometry. Under 980nm excitation, Tm3+/Yb3+ co-doped Gd2Mo3O9 has exhibited a weak red emission near 651m and strong blue emission at 476nm. Tm3+/Yb3+ co-doped Gd2Mo3O9 phosphor has been considered as a better candidate in solid-state lighting applications.",
        "keywords": [
            "blue emitting phosphor",
            "rare earths",
            "upconversion"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Bing Xue",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Guangchao Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Dianpeng Cui",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "ADVANCED MATERIALS AND ENGINEERING MATERIALS II",
        "year": 2013
    },
    "NLw746Wz": {
        "id": "NLw746Wz",
        "title": "Hydrothermal controlled synthesis and luminescence properties of NaLa(MoO 4) 2:Eu 3+ microcrystals",
        "abstract": "Eu 3+ doped NaLa(MoO 4) 2 microcrystals with different sizes are synthesized by a mild hydrothermal method, and the morphologies of the microcrystals can be easily controlled by adjusting the volume ratio of ethylene glycol to water and the aging time. Uniform high-quality shuttle-like microcrystals with an average length of 2.0 μm are obtained under the hydrothermal condition of 180°C for 16 h. From the emission spectra of NaLa(MoO 4) 2:Eu 3+ microcrystals, it is concluded that the dopant Eu 3+ ion occupies a La 3+ site. It is indicated that the concentration quenching of the emission peak at 613 nm of Eu 3+ is ascribed to the electric dipole-electric quadrupole interaction, and the cross relaxation process of Eu 3+( 5D 1) + Eu 3+( 7F 0) →Eu 3+( 5D 0) + Eu 3+( 7F 3) appear. © Chinese Physical Society.",
        "keywords": [
            "Hydrothermal synthesis",
            "Luminescence",
            "Molybdate",
            "Rare-earth ions"
        ],
        "authors": [
            {
                "name": "Sun Jia-Yue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Chun Cao",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Du Hai-Yan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2011
    },
    "nqDmwQTB": {
        "id": "nqDmwQTB",
        "title": "Characterization and luminescence properties of Sr3Gd(PO4)3: Sm3+ orange–red phosphor",
        "abstract": "",
        "keywords": [
            "light emitting diodes",
            "luminescence",
            "ions"
        ],
        "authors": [
            {
                "name": "zaifa yang",
                "org": "beijing technology and business university"
            },
            {
                "name": "denghui xu",
                "org": "beijing technology and business university"
            },
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "yumei sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            }
        ],
        "venue": "Optical Engineering",
        "year": 2015
    },
    "B7JkEYCP": {
        "id": "B7JkEYCP",
        "title": "Synthesis of Yb3+/Tm3+co-doped MF2 (M=Ca,Sr,Ba) nanocrystals with blue up-converted fluorescence",
        "abstract": "A series of MF2:Yb3+/Tm3+(M=Ca, Sr, Ba) upconverted nanocrystals were synthesized by hydrothermal method. Polyvinylpyrrolidone(PVP) is an surfactant which can render the nanocrystals dispersible in water and ethanol. Upconverted emission was also detected in the red and NIR regions of the spectrum and assigned to the 1G 4-3F4 (centered at 650 nm) and 3H4-3H6 (centered at 800 nm) transitions, respectively. In addition, MF2:Yb3+/Tm 3+ NCs show bright blue upconverted emission under the 980 nm excitation. As-synthesized MF2:Yb3+/Tm3+ luminescent NCs might find some potential applications in areas of photoluminescence and displays. © (2011) Trans Tech Publications.",
        "keywords": [
            "alkaline earth metal fluorides",
            "nanocrystals",
            "up-converted",
            "nanocrystal"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianbo B. Xian",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "1HfJdCrn": {
        "id": "1HfJdCrn",
        "title": "Sol-gel synthesis and green upconversion luminescence in BaGd 2(MoO4)4:Yb3+,Er3+ phosphors",
        "abstract": "Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 phosphor powders were prepared by the Sol–gel method and the upconversion luminescence properties were investigated in detail. Under 980 nm semiconductor laser excitation, BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphor exhibits green upconversion luminescence with peaks at 530 and 550 nm, which are due to the transitions of Er 3+ ( 2 H 11/2 ) → Er 3+ ( 4 I 15/2 ) and Er 3+ ( 4 S 3/2 ) → Er 3+ ( 4 I 15/2 ), respectively. Both of the two green emission lines are produced by populating Er 3+ ions to the excited state through a two-photon process. By monitoring the intensities of the green upconversion luminescence, the optimum conditions for the Sol–gel synthesis were determined when the molar ratio of citric acid to total chelate metal cations was 2:1 and the sintering temperature was at 1073 K. The concentration quenching effect for Er 3+ was found at the optimum doping concentration of 6 mol%, and the critical distance for the neighboring Er 3+ was determined to be about 21.5 Å. Keywords Upconversion luminescence Optical properties Sol–gel synthesis 1 Introduction Recently, the researches on rare earth ions doped upconversion luminescence (UL) materials have received a considerable attention because of their applications in many advanced technology fields, such as three-dimensional display [1] , photonics [2] , upconversion luminescence lasers [3,4] , temperature sensors [5] , DNA detection [6] and biological analyses as biolabels [7,8] , and so on. In order to fulfill the corresponding requirements in various application fields, many research papers on developing new UL materials systems have been reported. The selected BaGd 2 (MoO 4 ) 4 compound in this paper belongs to a group of double barium lanthanide molybdates BaLn 2 (MoO 4 ) 4 (Ln = Y, La–Lu) [9,10] . The structure of this scheelite-like compound, which is different from the scheelite one, contains a MoO 4 tetrahedron, a distorted GdO 8 polyhedron and Ba 2+ ions in the tenfold coordination [11] . It belongs to the monoclinic crystal category and has the space group C2/c with the cell parameters a = 5.2694 Å, b = 12.6659 Å, c = 19.4108 Å and β = 91.399 [12] . In our previous study, the Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 phosphor has been synthesized by high-temperature solid state method [13] . It is known that the co-doping behavior of rare earth activator ions can increase the efficiency of luminescence. So Yb 3+ is chosen as the co-dopant with Er 3+ , because it possesses a large absorption cross section at 980 nm, and the upconversion luminescence of Yb 3+ /Er 3+ doped molybdate and tungstate crystals have been reported [14,15] . Among them, metastable level 4 I 9/2 and 4 I 11/2 of Er 3+ ions can be populated upon 980 nm excitation [16,17] . However, a distinct enhancement of the intensity of upconversion luminescence was observed when Yb 3+ ion was doped as sensitizer [18,19] . Because Yb 3+ ion possesses a larger absorption cross section at 980 nm than Er 3+ , more Er 3+ ions can be populated to the excited-state by energy transfer from Yb 3+ ions, causing the enhancement of the emission of upconversion luminescence [20,21] . It is well-known that the solid state method used to prepare phosphor powders will result in the increase of particle sizes, which leads to poor adhesion to the substrate and loss of coating in practical application. However, Sol–gel method is one of the most important “soft chemistry” techniques for the synthesis of phosphor materials with higher uniformity in particle size distribution and non-agglomeration, and ultrafine powders [22] . In this paper, we reported the preparation of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphors by sol–gel method process and their luminescence properties, and the possible upconversion luminescence mechanisms were also discussed. 2 Experimental Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 powder samples were prepared by the sol–gel method. The starting materials were Ba(NO 3 ) 2 (A.R.), (NH 4 ) 6 Mo 7 O 24 ·4H 2 O (A.R.), Gd 2 O 3 (99.99%), Yb 2 O 3 (99.99%), Er 2 O 3 (99.99%), HNO 3 (A.R.), citric acid (A.R.) and distilled water. Rare earth oxides Gd 2 O 3 , Yb 2 O 3 , Er 2 O 3 were dissolved in HNO 3 , and corresponding rare earth nitrate solutions were formed. Then stoichiometric amount of Ba(NO 3 ) 2 and (NH 4 ) 6 Mo 7 O 24 ·4H 2 O were added under vigorous stirring. Citric acid was used as chelating agent for the metal ions. The molar ratio of citric acid to total chelate metal cations was x :1 ( x = 1–5). At the end, the pH value of the mixed solution was adjusted to 7–8 by the addition of suitable amount of dilute NH 3 ·H 2 O, and the highly transparent solution was obtained after stirring for a few minutes. With continuous heating at 403 K, the solution became viscous by evaporation and then turned into an ash-like solid precursor. Fine-sized UL phosphors were finally obtained after calcinations at different temperature (873–1173 K) for 4 h in air. As a comparison, BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 was synthesized by the high-temperature solid state method at 1273 K, as reported in the Ref. [13] . Thermogravimetry–differential thermal analysis (TG–DTA) for the precursor was performed on a SHIMADZU DTA-60H instrument. The analyzer was operated at a heat rate of 10 °C/min from room temperature to a maximum temperature of 1173 K. The X-ray diffraction (XRD) patterns were recorded by using a SHIMADZU model XRD-6000 X-ray powder diffractometer (Cu Kα radiation, 40 kV, 30 mA and a scanning speed 2.0° (2 θ )/min.). The size and shape of the particles were analyzed by a scanning electron microscope (SEM, JOEL, JSM-6490). The upconversion luminescence spectra were recorded on a Hitachi F-4500 spectrophotometer equipped with an external power-controllable 980 nm semiconductor laser (Beijing Viasho Technology Company, China) as the excitation source, which is connected with an optic fiber accessory. 3 Results and discussion Fig. 1 gives the TG–DTA curves of precursors of BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 with different amount of citric acid. As seen in Fig. 1 (a), there are three weak endothermic peaks before the temperature gets to 450 K, which is due to the evaporation of small amount of absorbed or bonding water in different bonding state for the present complex precursor system. The weight loss of the precursor occurs in the TG curve from 450 to 546 K, which also corresponds to a strong exothermic peak at 478 K in DTA curve. This stage should originate from the decomposition and burning of organic chelate agents. After that, there is an endothermic peak from 540 to 850 K in DTA curve, but no obvious weight loss can be found in TG curve, which indicates the final formation of the single phase BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 materials. In Fig. 1 (b), the position of the exothermic and endothermic peaks are nearly the same as Fig. 1 (a), which indicates that the amount of citric acid was not related to the temperature of the formation of the phosphors. Fig. 2 exhibits the XRD pattern of the BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 samples obtained by sintering the precursor at different temperature and the JCPDS Card No.36-0192. As shown in the graph, 873 K is high enough to form the phase of the upconversion luminescence phosphor, and the XRD pattern of the samples have no obvious differences when the reaction temperature is changed from 873 to 1173 K, which also indicates that the upconversion luminescence powder can be achieved after sintering the precursor at 873 K. By comparisons among the given XRD pattern, we confirm that the crystal structure of the as-synthesized Yb 3+ /Er 3+ codoped BaGd 2 (MoO 4 ) 4 phosphor are in good agreement with the standard value from the JCPDS file of BaGd 2 (MoO 4 ) 4 except some extra peaks of data of Mo 4 O 11 and Mo 9 O 26 . It means that the BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 phosphor can be obtained successfully by the sol–gel method. Fig. 3 displays the XRD pattern of the BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 powders with different concentrations of citric acid when the reaction temperature was 1073 K. it can be concluded from the picture that the reactions for all the samples were complete. To further understand the crystal growth process of the BaGd 1.54 Yb 0.4 Er 0.06 (MoO 4 ) 4 phosphors, we investigated the morphology of the as-prepared products which are obtained at different reaction temperatures. Fig. 4 shows SEM images of the samples which are achieved by sintering precursors at different temperature (873 K, 973 K, 1073 K and 1173 K) for 4 h, respectively. As seen from Fig. 4 , there is an obvious grain growth trend with increasing temperature. The sample sintered at 873 K has the smallest grain size, which is less than 1 μm. The grain size of the powder is growing up while the temperature is increasing, and the lager grain (3– μm) can be found when the reaction temperature reach 1173 K. Particle aggregation took place with the increasing temperature, and the phosphor became blocky microcrystals when the sample was obtained by annealing the precursor at 1173 K. The upconversion luminescence properties of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ with different amount of citric acid after sintering the precursor from 873 to 1173 K are comparatively investigated in detail under 980 nm semiconductor laser excitation. As shown in Fig. 5 , two peaks at 530 nm and 550 nm of intense green emissions attributed to the transition emission of Er 3+ ( 2 H 11/2 → 4 I 15/2 and 4 S 3/2 → 4 I 15/2 ) are observed. Fig. 5 (a) gives the upconversion luminescence spectra of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ phosphor for calcination at 873 K, and the molar ratio of citric acid to total chelate metal cations was x :1 ( x = 1–5). It can be seen from the graph that the emission intensity maximizes when the ratio was 2:1. Similarly, as given in Fig. 4 (b–d), when the ratio was 2:1, the emission intensity reaches a maximum by sintering the samples at 973 K, 1073 K and 1173 K, respectively. In our work, we confirm that the optimum molar ration of citric acid to the metal cations for complete reaction should be 2:1, because the emission intensity of the samples with this concentration of chelating agent is stronger than any others. Fig. 6 shows the upconversion luminescence spectra of BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ phosphor under 980 nm semiconductor laser excitation for different reaction temperature, and the molar ratio of citric acid to total chelate metal cations was 2:1. As seen from the graph, the upconversion luminescence emission intensity increases with the increasing reaction temperature, maximizes at 1073 K, and then decreases at 1173 K. Eventually, we confirm that optimum temperature for sintering the precursor is at 1073 K. In our former study, the phosphor with intensive green emission of upconversion luminescence has been synthesized by the solid state reaction [13] . In order to prepare ultrafine powder with stronger luminescence intensity, the same BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ phosphor was obtained by sol–gel synthesis. Fig. 7 displays the upconversion luminescence intensities of the phosphors obtained by sol–gel method and the high-temperature solid state method, respectively. The concentrations of Yb 3+ and Er 3+ of the sample synthesized by sol–gel method is the same as the earlier sintered powder in our previous work [13] , which are 40 mol% and 6 mol%, respectively. As seen from Fig. 7 , the powder prepared by solid state method has a little stronger luminescence intensity. But as mentioned above, we can obtain the phosphor powders with higher uniformity in particle size distribution by sol–gel synthesis compared to the solid state method, which helps to obtain the practical application of the phosphor powders. The upconversion visible emissions of BaGd 2 (MoO 4 ) 4 :Yb 3+ ,Er 3+ are produced through multiple process including ground-state absorption (GSA), excited-state absorption (ESA) and energy transfer (ET) when excited with 980 nm semiconductor laser. The possible upconversion luminescence mechanism is shown in Fig. 8 . An Yb 3+ ion is excited by a 980 nm photon from ground state ( 2 F 7/2 ) to ( 2 F 5/2 ) through GSA process, and then promotes an Er 3+ ion from 4 I 15/2 to 4 I 11/2 by transferring the energy to it. Then the excited Er 3+ ion transits to a higher level at 4 F 7/2 when another Yb 3+ ion at 2 F 5/2 level continuously transfers the energy to it. Besides, the Er 3+ ion can be excited to 4 I 11/2 by a GSA process. And then the Er 3+ ion at excited state can also be promoted to the 4 F 7/2 level by absorbing a 980 nm photon through an ESA process. The populated level 4 F 7/2 decays non-radiatively to 2 H 11/2 and 4 S 3/2 , finally produces green emissions at 530 nm and 550 nm with a radiative transition to ground state 4 I 15/2 , respectively. It can be concluded that the occurrence of green upconversion can be attributed to a two-photon process. Moreover, cross relaxation occurs between the Er 3+ ions at level 4 I 11/2 and 4 I 13/2. The excited Er 3+ at level 4 I 11/2 relaxes to 4 I 13/2 with non-radiative transition. Then the Er 3+ of level 4 I 13/2 return to ground state 2 F 7/2 , transferring the energy to that of level 4 I 11/2, which promotes it to 4 F 7/2 level. The dependence of upconversion luminescence intensity upon the excitation power of laser diode is shown in Fig. 9 to further understand the involved mechanism. The relationship between the intensity of the upconversion luminescence and the infrared excitation can be approximately expressed as follow: I uc ∝ P n , where n is the number of infrared photons absorbed for emitting a visible photon. In the double-log coordinate graph shown in Fig. 9 , the slope of I uc − P n indicates the value of n , which is used for the deduction of the possible upconversion luminescence process. The value of n for emissions at 530 nm and 550 nm are 1.72 and 1.74, respectively. The decrease of n due to the competition between linear decay and upconversion processes for the depletion of the intermediate excited states has been reported [23] . The upconversion luminescence intensity for an n -photon energy transfer process was proportional to the n -th power of the excitation power ( P n ) in the limit of the infinitely small upconversion rates, while the intensity was proportional to the excitation power ( P 1 ) in the limit of infinitely large upconversion rates. Therefore, the intensity of an upconversion luminescence excited by the sequential absorption of n photons has a dependence of P β on absorbed excitation power P with 1 < β < n [23] , which give rise to the phenomenon that the slope coefficient is less than 2 in fig. 9 . As the result, it can be concluded that the green emission of BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ phosphor is originated from a two-photon process. Further, the quenching effect of Er 3+ ion is also investigated. Fig. 10 shows the upconversion luminescence spectra of BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ excited by a 980 nm semiconductor laser for different Er 3+ concentration and invariable Yb 3+ concentration (40 mol%). With increasing Er 3+ concentration, the green emission intensity increases, maximizes at 6 mol%, and then decreases. It can be seen from the inset of the Fig. 10 that the quenching effect for the green emission of BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ is obvious when the concentration of Er 3+ is increasing. The concentration quenching is explained by the energy transfer between nearest Er 3+ ions. That is, the probability for a non-radiative energy transfer between Er 3+ ions increases with increasing the Er 3+ concentration. Such a non-radiative energy transfer occurs as a consequence of an exchange interaction or multipole–multipole interaction. In the case of the Er 3+ ion, the exchange interaction is responsible for energy transfer for forbidden transitions [24] . Then, the critical distance corresponding to the critical quenching concentration can be estimated by the following equation [25] . (1) R c ≈ 2 3 V 4 π x c N 1 3 where V is the unit cell volume, N is the number of Gd 3+ (Yb 3+ , Er 3+ ) ions in the present BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ unit cell, and x c is critical concentration. According to crystal structure data of the BaGd 2 (MoO 4 ) 4 compound, it has a monoclinic phase, its cell volume ( V ) is 1295.06 Å, and the N value is 4. Considering the critical concentration is 0.06, the critical distance is about 21.5 Å. 4 Conclusion In conclusion, green upconversion luminescence phosphor BaGd 2 (MoO 4 ) 4 :Yb 3+ , Er 3+ has been synthesized by the sol–gel method. The morphologies of the phosphor are analyzed by SEM, and the grain growth trend with increasing temperature is observed. The luminescent properties and the effects of the sintering temperature and the amount of the chelating agent (citric acid) have been investigated in detail. The intensity of the green upconversion luminescence emission arrives at maximum when the molar ratio of citric acid to total chelate metal cations is 2:1 and the temperature of synthesis is at 1073 K. It is concluded that the green emissions at 530 nm and 550 nm which are due to the transition of Er 3+ ( 2 H 11/2 ) → Er 3+ ( 4 I 15/2 ) and Er 3+ ( 4 S 3/2 ) → Er 3+ ( 4 I 15/2 ) are produced through a two-photon process. The quenching effect of the Er 3+ concentration has also been studied. The optimum Er 3+ doping concentration should be 6 mol%, and the critical distance for the neighboring Er 3+ was determined to be about 21.5 Å. Acknowledgements This present work was supported by the National Natural Science Foundation of China (Nos. 20876002 and 20976002 ), the Beijing Natural Science Foundation (No. 2091002 ), and Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality. References [1] E. Dowing L. Hesselink J. Ralston R. Macfarlane Science 273 1996 1185 [2] G.Y. Chen Y. Liu Y.G. Zhang G. Somesfalean Z.G. Zhang Q. Sun F.P. Wang Appl. Phys. Lett. 91 2007 133103 [3] F. Liu E. Ma D.Q. Chen Y.L. Yu Y.S. Wang J. Phys. Chem. B 110 2006 20843 [4] S. Sivakumar Van Veggel C.J.M. Fank M. Raudsepp J. Am. Chem. Soc. 127 2005 12464 [5] X. Wang X.G. Kong Y. Yu Y.J. Sun H. Zhang J. Phys. Chem. C 111 2007 15119 [6] L.Y. Wang Y.D. Li Chem. Commun. 2006 2557 [7] F. Vetrone J.C. Boyer J.A. Capobianco A. Speghini M. Bettinelli J. Phys. Chem. B 106 2002 5622 [8] E. De la Rosa L.A. Diaz R.A. Rodriguez M.A. Meneses O. Barbosa P. Salas Appl. Phys. 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Pollnau J. Lumin. 128 2008 934 [21] Z.X. Cheng S.J. Zhang F. Song H.C. Guo J.R. Han H.C. Chen J. Phys. Chem. Solids 63 2002 2011 [22] F. Song L. Han H. Tan J. Su J. Yang J.G. Tian G.Y. Zhang Z.X. Cheng H.C. Chen Opt. Commun. 259 2006 179 [23] M. Pollnau D.R. Gamelin S.R. Lüthi H.U. Güdel Phys. Rev. B 61 2000 3337 [24] D.L. Dexter J.H. Schulman J. Chem. Phys. 22 1954 1063 [25] G. Blasse J. Solid State Chem. 62 1986 207",
        "keywords": [
            "Optical properties",
            "Sol-gel synthesis",
            "Upconversion luminescence"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Yujing Lan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Optical Materials",
        "year": 2011
    },
    "ISSOO2ga": {
        "id": "ISSOO2ga",
        "title": "Luminescent properties of LiBaPO4:RE (RE = Eu2+, Tb3+, Sm3+) phosphors for white light-emitting diodes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "xiangyan zhang",
                "org": ""
            },
            {
                "name": "zhiguo xia",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2012
    },
    "nTDmRgWh": {
        "id": "nTDmRgWh",
        "title": "Tunable luminescence of Ce 3+ /Mn 2+ -coactivated Sr 3 Gd(PO 4 ) 3 with efficient energy transfer for white-light-emitting diode",
        "abstract": "",
        "keywords": [
            "chemical synthesis",
            "energy transfer"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "junhui zeng",
                "org": ""
            },
            {
                "name": "yining sun",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Luminescence",
        "year": 2013
    },
    "pte1Ycs9": {
        "id": "pte1Ycs9",
        "title": "Preparation and spectra characterization of optically variable pigments with four symmetrical configurations",
        "abstract": "The optically variable pigments with four symmetrical configurations were obtained by using the mica titanium as the host materials, which was pretreated in acid and alkaline condition. The reflection differences between the host materials and the coatings were increased by optimizing the number of layers and the arrangement order. The optically variable effect was investigated by X-Rite MA86 II five angles spectrophotometer. The impact of symmetrical configurations on improving the color travel effect was studied, and the influence of different coating materials on the hue and the color travel effect was researched. The results show that the reflection rate and the color travel effect of the pigment were improved by coating another material on three symmetrical configurations.",
        "keywords": [
            "Four symmetrical configurations",
            "Optically variable",
            "Pigment",
            "Spectra",
            "Wetting chemical method"
        ],
        "authors": [
            {
                "name": "Hai-Yan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Qirong Rong Chen",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jia-Yue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",
        "year": 2007
    },
    "kA941eE8": {
        "id": "kA941eE8",
        "title": "Luminescence properties of Ba2 Mg (BO3) 2: Eu2+ red phosphors synthesized by a microwave-assisted sol-gel route",
        "abstract": "Fine-sized red-emitting Ba2-x Mg (BO3) 2:x Eu2+ phosphors were synthesized via a microwave-assisted sol-gel route. The crystallization process, structure, and morphology of the as-synthesized phosphor were characterized by thermogravimetry-differential thermal analysis, X-ray diffraction, and scanning electron microscopy analysis, respectively. The luminescence properties were characterized by diffuse reflection spectra (UV-visible) and photoluminescence spectra. The as-prepared phosphors had good excitation characteristics in the region of 320-450 nm, which perfectly matched the emission wavelength of near-UV light emitting diodes. Intense red emission peaking at 608 nm was obtained upon 365 nm excitation with the chromaticity coordinates of (0.585, 0.402). The energy transfer among the nearest-neighbor ions resulted in the concentration quenching of Ba2 Mg (BO3) 2: Eu2+phosphor, and the critical distance was determined to be about 17.32 Å. © 2009 The Electrochemical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianfeng Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of the Electrochemical Society",
        "year": 2009
    },
    "yR8vsP1W": {
        "id": "yR8vsP1W",
        "title": "Visible-Light Responding BiVO_4/TiO_2 Nanocomposite Photocatalyst",
        "abstract": "The two kinds of new nanocomposites BiVO4/TiO2 nanowires were synthesized by hydrothermal process.Their crystal structure,morphology and photocatalytic activities for degradation of methylene blue solution were characterized using various measurement techniques.The XRD results indicate that they are made up of monoclinic BiVO4 and anatase TiO2 phases.The SEM,TEM and HRTEM images show that the two samples include BiVO4 nanoparticles supported onto TiO2 nanowires.The UV-Vis absorption spectra reveal that the absorption edges of the samples exhibit red-shift in comparison with that of the pure TiO2 nanowires.The measurement results for the visible-light photodegradation of methylene blue show that the nanocomposite sample prepared from the layered titanate nanowires with Bi3+ has the highest photocatalytic activity.",
        "keywords": [
            "Hydrothermal synthesis",
            "Photocatalyst",
            "Visible responding",
            "BiVO4/TiO2",
            "Nanocomposite"
        ],
        "authors": [
            {
                "name": "JI Tian-hao",
                "org": " College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "YANG Fang",
                "org": " College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "ZHOU Jiao-yan",
                "org": " College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": " College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": " College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Spectroscopy and Spectral Analysis",
        "year": 2010
    },
    "LjMAwwRv": {
        "id": "LjMAwwRv",
        "title": "Research on Properties of Energy Storage and Photoluminescence PVC Boards",
        "abstract": "Long afterglow phosphorescent material is a material that can absorb light in daytime and re emit light at night. PVC was filled with such phosphorescent powder and the luminescent behavior and mechanical properties were investigated. It is found that the afterglow strength of the PVC boards increased , but the tensile strength and light transmittance decreased with increasing content of phosphorescent powder. When the loading of phosphorescent powder is 8 phr, both afterglow strength and tensile strength of PVC boards were satisfactory. SEM indicated that the phosphorescent powder was well dispersed in PVC matrix.",
        "keywords": [
            "afterglow",
            "poly(vinyl chloride) board",
            "photoluminescence"
        ],
        "authors": [
            {
                "name": "SUN Jia-yue",
                "org": ""
            },
            {
                "name": "XIANG Ai-min",
                "org": ""
            },
            {
                "name": "DU Hai-yan",
                "org": ""
            },
            {
                "name": "LI Ji-zhong",
                "org": ""
            },
            {
                "name": "XU Wen-cai",
                "org": ""
            },
            {
                "name": "MA Er-jun",
                "org": ""
            }
        ],
        "venue": "China Plastics",
        "year": 2006
    },
    "ipRMsfhq": {
        "id": "ipRMsfhq",
        "title": "Preparation and characterization of upconversion nanocomposite for β-NaYF4:Yb3+,Er3+-supported TiO 2 nanobelts",
        "abstract": "Hexagonal NaYF4:Yb3+,Er3+ (β-NaYF4:Yb3+,Er3+) nanoparticles supported on TiO2 nanobelts were prepared using two-step procedures of ion-exchangeable process and hydrothermal treatment: layered titanate nanobelts were first ion-exchanged with Y3+, Yb3+ and Er3+ cations to produce titanate nanobelts with these cations, and then, the product nanobelts in NaY solution were treated under hydrothermal condition to transform into anatase TiO2 nanobelts supported with β-NaYF4:Yb3+,Er3+ nanoparticles. The final products were characterized by various measurement techniques. Many preparation conditions, e.g., the content of added precursors, reaction time and pH value, were optimized to obtain nanocomposites including relatively uniform nanoparticles with strong upconversion (UC) emission intensity. The measurement results showed that the anatase TiO2 nanobelts, supported by the large number of β-NaYF4:Yb3+,Er3+ nanoparticles with 30-70 diameter range and very strong UC emission, could be achieved under suitable preparation condition. The UC emission intensity of the nanoparticles with the concentrations of Yb3+ and Er3+ closer to 20 mol. and 1 mol. was the strongest. © 2010 The Chinese Society of Rare Earths.",
        "keywords": [
            "nanocomposites",
            "NaYF4:Yb3+",
            "Er3+",
            "TiO2 nanobelt",
            "upconversion"
        ],
        "authors": [
            {
                "name": "Tianhao Ji",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Fang Yang",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Hong Guo",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "Jianshi Yang",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2010
    },
    "lHdiQ9yq": {
        "id": "lHdiQ9yq",
        "title": "Synthesis and luminescence properties of novel LiSrPO4:Dy3+ phosphor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "xiangyan zhang",
                "org": ""
            },
            {
                "name": "zhiguo xia",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2011
    },
    "Yp2VvAgR": {
        "id": "Yp2VvAgR",
        "title": "Hydrothermal synthesis of BaYF 5 :Yb 3+ /Er 3+ upconversion luminescence submicrospheres by a surfactant-free aqueous solution route",
        "abstract": "",
        "keywords": [
            "chemical synthesis",
            "aqueous solution",
            "transmission electron microscope",
            "x ray diffraction",
            "reaction time",
            "scanning probe microscope",
            "scanning electron microscope"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "jianbo xian",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Journal of Physics and Chemistry of Solids",
        "year": 2011
    },
    "dnou1hgD": {
        "id": "dnou1hgD",
        "title": "Synthetic methods and application of upconversion luminescence materials",
        "abstract": "This paper generalized several synthetic methods of this materials used presently at home and abroad.The synthetic methods included high temperature solid method,sol-gel process,hydrothermal synthesis,co-precipitation method and so on.The advantages and disadvantages of every method were discussed.Moreover,the synthetic methods of upconversion luminescence materials for further development were prospected.The application of upconversion technology was introduced.",
        "keywords": [
            "luminescence material",
            "synthetic methods",
            "upconversion"
        ],
        "authors": [
            {
                "name": "Yang Zhiping",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2009
    },
    "b3rD7ZWu": {
        "id": "b3rD7ZWu",
        "title": "Bright white up-conversion emission from Er 3+ /Ho 3+ /Tm 3+ /Yb 3+ co-doped YVO 4 phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "jicheng zhu",
                "org": ""
            },
            {
                "name": "xiaotang liu",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2013
    },
    "97oUTChz": {
        "id": "97oUTChz",
        "title": "The red-emitting phosphor of Sm 3+-doped Y 2Si 4N 6C",
        "abstract": "A new red-emitting Rare-earth silicon carbonitrides phosphor, Y2Si4N6C, was prepared by a carbothermal reduction and nitridation method. X-ray powder diffraction (XRD), the photoluminescence excitation and emission spectra, temperature dependent was measured. The emission spectrum obtained by excitation into 410 nm contains exclusively the characteristic emission of Sm3+ at 568, 607 and 654 nm which correspond to the transitions from (4)G(5/2) to H-6(5/2), H-6(7/2), and H-6(9/2) of Sm3+, respectively. The strongest one is located at 606 nm due to (4)G(5/2) to H-6(7/2) transition of Sm3+.",
        "keywords": [
            "The red-emitting phosphors",
            "Luminescent properties",
            "silicon carbonitrides"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "PROGRESS IN NEW MATERIALS AND MECHANICS RESEARCH",
        "year": 2012
    },
    "TtYDDx3D": {
        "id": "TtYDDx3D",
        "title": "Luminescence properties of double-perovskite Sr2Ca1−2x Eu x Na x MoO6 red-emitting phosphors prepared by the citric acid-assisted sol–gel method",
        "abstract": "Double-perovskite Sr2Ca1−2x Eu x Na x MoO6 red-emitting phosphors were prepared by the citric acid-assisted sol–gel method, and their luminescence properties were investigated as a function of sintering temperature and Eu3+-doping concentration. B-site substituted Sr2Ca0.8Eu0.1Na0.1MoO6 phosphor, in which Na+ ions act as charge compensators, was selected to study the thermal behavior, phase structure, microstructure, and photoluminescence property under different sintering temperatures. The photoluminescence studies on Sr2Ca1−2x Eu x Na x MoO6 (x = 0.02, 0.05, 0.10, 0.15, 0.2) show that a dominant red emission line at around 594 nm, which is due to the Eu3+ magnetic dipole transition of 5D0–7F1, is observed under different Eu3+ excitations (396 and 412 nm). Further, Eu3+ dopant content dependent emission spectra investigations of Sr2Ca1−2x Eu x Na x MoO6 phosphors indicates that, when the Eu3+ concentrations x = 0.05, there are minimum differences between the emission intensity of 5D0–7F1 transition at 594 nm and that of 5D0–7F2 transition at 615 nm. With increasing Eu3+ concentration, the variation of the emission intensities between the two transitions keep nearly invariable and Sr2Ca0.8Eu0.1Na0.1MoO6 phosphor has the strongest red emission in this series.",
        "keywords": [
            "emission line",
            "microstructures",
            "sol gel method"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "School of Materials Sciences and Technology,China University of Geosciences,Beijing,China"
            },
            {
                "name": "Jianfeng Sun",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing,China"
            },
            {
                "name": "Daimei Chen",
                "org": "School of Materials Sciences and Technology,China University of Geosciences,Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing,China"
            }
        ],
        "venue": "Journal of Materials Science",
        "year": 2010
    },
    "sim5SjAH": {
        "id": "sim5SjAH",
        "title": "White upconverted luminescence of Ho3+/Yb3+/Tm3+ tri-doped Gd2Mo3O9 phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "bing xue",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Science and Engineering B-advanced Functional Solid-state Materials",
        "year": 2013
    },
    "fSTsRTGN": {
        "id": "fSTsRTGN",
        "title": "Preparation and up-conversion fluorescence of rare earth (Er{sup 3+} or Yb{sup 3+}/Er{sup 3+})-doped TiO nanobelts",
        "abstract": "",
        "keywords": [
            "ion exchange",
            "charged particles",
            "electron microscopy",
            "titanium oxide",
            "titanium",
            "scanning electron microscopy"
        ],
        "authors": [
            {
                "name": "tianhao ji",
                "org": "beijing technology and business university"
            },
            {
                "name": "yang liu",
                "org": ""
            },
            {
                "name": "hui zhao",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            },
            {
                "name": "guanglu ge",
                "org": ""
            }
        ],
        "venue": "Journal of Solid State Chemistry",
        "year": 2010
    },
    "yGrv9PEL": {
        "id": "yGrv9PEL",
        "title": "Luminescence of Eu 2+ in alkali earth chlorosilicate phosphor and their color-tunable properties",
        "abstract": "",
        "keywords": [
            "spectra",
            "luminescence"
        ],
        "authors": [
            {
                "name": "zhiguo xia",
                "org": ""
            },
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "wei zhou",
                "org": ""
            }
        ],
        "venue": "Optical Materials",
        "year": 2006
    },
    "ceOSaNb7": {
        "id": "ceOSaNb7",
        "title": "Bright white up-conversion emission from Er3+/Ho 3+/Tm3+/Yb3+ co-doped YVO4 phosphors",
        "abstract": "Er3+/Ho3+/Yb3+/Tm3+ co-doped YVO4 phosphors were synthesized by the conventional solid-state reaction. Under 980 nm laser diode excitation, intense red, green and blue up-conversion emissions were observed for the Yb3+/Er3+, Yb3+/Ho3+ and Yb3+/Tm3+ couples in the YVO4 host, respectively, which were due to the successive energy transfer from Yb3+ to Er3+, Ho3+ or Tm 3+. Bright white luminescence upon 980 nm near-infrared excitation can be observed for the sample at the optimum chemical composition of YVO 4:10%Yb3+/1%Tm3+/0.3%Ho3+/0. 2%Er3+. Under different excitation pump powers, the obtained optimal color coordinate (0.323, 0.325) is very close to the standard white light (0.333, 0.333) coordinate. © 2013 Elsevier Ltd.",
        "keywords": [
            "A. Optical materials",
            "C. X-ray diffraction",
            "D. Optical properties"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "",
                "org": "South China Agricultural University(South China Agricultural University),Guangzhou,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2013
    },
    "rqyLISmH": {
        "id": "rqyLISmH",
        "title": "A novel blue-emitting Ca 2 B 5 O 9 Br:Eu 2+ phosphor prepared by a microwave calcination route",
        "abstract": "",
        "keywords": [
            "scanning electron microscopy",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "zhiguo xia",
                "org": "china university of geosciences"
            },
            {
                "name": "haiyan du",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "jiayue sun",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "daimei chen",
                "org": "china university of geosciences"
            },
            {
                "name": "xuefeng wang",
                "org": "china university of geosciences"
            }
        ],
        "venue": "Materials Chemistry and Physics",
        "year": 2010
    },
    "hvPblmuD": {
        "id": "hvPblmuD",
        "title": "Preparation and characterization of Ti 1 − x Zr x O 2 /ZrO 2 nanocomposite",
        "abstract": "",
        "keywords": [
            "nanocomposite",
            "zirconia",
            "doping"
        ],
        "authors": [
            {
                "name": "li wang",
                "org": "beihang university"
            },
            {
                "name": "fang yang",
                "org": "beihang university"
            },
            {
                "name": "tianhao ji",
                "org": "beihang university"
            },
            {
                "name": "qinglin yang",
                "org": "beihang university"
            },
            {
                "name": "xingyi qi",
                "org": "beihang university"
            },
            {
                "name": "haiyan du",
                "org": "beijing technology and business university"
            },
            {
                "name": "jiayue sun",
                "org": "beijing technology and business university"
            }
        ],
        "venue": "Scripta Materialia",
        "year": 2008
    },
    "ySZiaTUB": {
        "id": "ySZiaTUB",
        "title": "NIR-to-blue, green, orange and white up-conversion luminescence in Yb 3+/Tm3+/Er3+/Ho3+-doped Na 0.5Gd0.5WO4 nanocrystals",
        "abstract": "Yb3+/Tm3+/Er3+/Ho3+-doped Na0.5Gd0.5WO4 nanocrystals have been fabricated by a facile hydrothermal method. The blue, green and orange upconversion (UC) emissions coming from Yb3+/Tm3+, Yb3+/Er3+, Yb 3+/Ho3+ dopant ions are observed in this study. Bright white luminescence upon 980 nm excitation can be produced via the UC process by tuning the dopant ions Yb3+/Tm3+/Ho3+, which consists of the blue, green and red UC emissions, and they correspond to the transitions 1G4 → 3H4 of Tm3+, 5F4(5S2) → 5I8, and 5F5 → 5I8 of Ho3+ ions, respectively. The UC mechanisms and temperature dependent UC luminescence were also discussed.",
        "keywords": [
            "Optical materials",
            "Optical properties",
            "Phosphors",
            "Upconversion luminescence"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Journal of Optoelectronics and Advanced Materials",
        "year": 2010
    },
    "SwcczqST": {
        "id": "SwcczqST",
        "title": "Preparation and characterization of Co-MoO3 Nanobelts",
        "abstract": "Co-embedded α-MoO3 (Co-MoO3) nanobelts were prepared using precursors CoCl2 and HxMoO3 nanobelts by hydrothermal and ion-exchangeable proceeding. The measurement results show that the crystalline phase and morphology of Co-MoO3 have not been changed yet after the CO2+ cations were embedded into the space between the two nearest-neighbored layers; by comparison of the FTIR spectra and XRD patterns for the two samples with and without the CO2+ cations, it can be also demonstrated that the H+ ions between the layers not only exist interaction with the oxygen atoms in MoO6, but also form new crystalline plane.",
        "keywords": [
            "Co-MoO3 nanobelts",
            "Hydrothermal preparation",
            "Ion-exchange"
        ],
        "authors": [
            {
                "name": "Tianhao Ji",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Yi Xiong Yang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2009
    },
    "rE6I8uLo": {
        "id": "rE6I8uLo",
        "title": "Luminescence properties of double-perovskite Sr2Ca 1-2x Eu x Na x MoO6 red-emitting phosphors prepared by the citric acid-assisted sol-gel method",
        "abstract": "Double-perovskite Sr2Ca1-2x Eu x Na x MoO6 red-emitting phosphors were prepared by the citric acid-assisted sol-gel method, and their luminescence properties were investigated as a function of sintering temperature and Eu3+-doping concentration. B-site substituted Sr2Ca0.8Eu 0.1Na0.1MoO6 phosphor, in which Na+ ions act as charge compensators, was selected to study the thermal behavior, phase structure, microstructure, and photoluminescence property under different sintering temperatures. The photoluminescence studies on Sr2Ca 1-2x Eu x Na x MoO6 (x = 0.02, 0.05, 0.10, 0.15, 0.2) show that a dominant red emission line at around 594 nm, which is due to the Eu3+ magnetic dipole transition of 5D 0-7F1, is observed under different Eu 3+ excitations (396 and 412 nm). Further, Eu3+ dopant content dependent emission spectra investigations of Sr2Ca 1-2x Eu x Na x MoO6 phosphors indicates that, when the Eu3+ concentrations x = 0.05, there are minimum differences between the emission intensity of 5D 0-7F1 transition at 594 nm and that of 5D0-7F2 transition at 615 nm. With increasing Eu3+ concentration, the variation of the emission intensities between the two transitions keep nearly invariable and Sr 2Ca0.8Eu0.1Na0.1MoO6 phosphor has the strongest red emission in this series. © 2009 Springer Science+Business Media, LLC.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jianfeng Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Daimei Chen",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Materials Science",
        "year": 2010
    },
    "9sQHybCB": {
        "id": "9sQHybCB",
        "title": "Stokes and Anti-Stokes Luminescence Research of NaYF_4:Eu~(3+),Tm~(3+),Yb~(3+)",
        "abstract": "The sample of NaYF4∶Eu,Tm,Yb was synthesized by coprecipitation method.The emission of NaYF4∶Eu,Tm,Yb excited by 360 nm is blue light with the peak at 452 nm from the transition of 1D2→3F4 of Tm3+.After being excited by 395 nm,NaYF4∶Eu,Tm,Yb emits orange light with the peak at 591 nm originating from the transition of 5D0→7F1 of Eu3+.When excited by 409 nm,NaYF4∶Eu,Tm,Yb emits red light with the peak at 613 nm from the transition of 5D0→7F2 of Eu3+.The color of upconversion luminescence of NaYF4∶Eu,Tm,Yb excited by 980 nm was blue and red.The upconversion spectrum exhibits distinct emission peaks at 459,478 and 641 nm.The blue light comes from the transition of 1G4→3H6 and 1D2→3F4 of Tm3+.The absorption spectrum was also researched.The red light results from the transition of 1G4→3F4 of Tm3+.The slope of the emission of 474 and 646 nm is 2.1 and 2.4 respectively.The emission of 478 and 641 nm is all due to three photon process.The structural properties of sample were characterized by X-ray diffraction(XRD) and scanning electron microscopy(SEM).The results show that NaYF4∶Tm3+,Yb3+ prepared by coprecipitation method exhibits a hexagonal crystal.",
        "keywords": [
            "Stokes and anti-Stokes luminescence",
            "Yb3+",
            "Co-precipitation method",
            "Product of NaYF4∶Eu3+",
            "Tm3+",
            "Rare earth ion"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "YANG Zhi-ping",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Spectroscopy and Spectral Analysis",
        "year": 2009
    },
    "EifSfSW1": {
        "id": "EifSfSW1",
        "title": "Phase structure and temperature dependent luminescence properties of Sr_2LiSiO_4F:Eu~(2+) and Sr_2MgSi_2O_7:Eu~(2+) phosphors",
        "abstract": "Green-emitting Sr2LiSiO4F:Eu2+ and blue-emitting Sr2MgSi2O7:Eu2+ phosphors were synthesized by the conventional high temperature solid-state route, respectively. Their structures and photoluminescence properties were comparatively investigated. It was found that the mixture phases of Sr2MgSi2O7 and SrF2 were obtained when a part of Sr2+ in Sr2LiSiO4F was replaced by some amount of Mg2+ in order to design the possible SrMgLiSiO4F:Eu2+ phosphor. Based on the photoluminescence analysis, Sr2LiSiO4F:Eu2+ phosphor exhibited a green broad emission band of main peak at 513 nm under the excitation of 365 nm, while the Sr2MgSi2O7:Eu2+ and SrMgLiSiO4F:Eu2+ phosphor showed blue emission centered at 467 nm. The temperature dependent photoluminescence properties and room temperature decay time for the three kinds of phosphors were also discussed in this paper.",
        "keywords": [
            "phosphor",
            "chlorosilicate",
            "rare earths",
            "white LED"
        ],
        "authors": [
            {
                "name": "XIA Zhiguo",
                "org": " School of Materials Sciences and Technology, China University of Geosciences, Beijing , China"
            },
            {
                "name": "SUN Jiayue",
                "org": " College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "LIAO Libing",
                "org": " School of Materials Sciences and Technology, China University of Geosciences, Beijing , China"
            },
            {
                "name": "d u haiyan",
                "org": " College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2010
    },
    "UGN2U9bh": {
        "id": "UGN2U9bh",
        "title": "Luminescence properties of a new red emitting Eu 3+ -doped alkaline-earth fluoborate phosphor: BaCa (1-2 x) BO 3 F: x Eu 3+ , x M + (M=Li, Na, K)",
        "abstract": "",
        "keywords": [
            "diffuse reflectance",
            "phosphor",
            "x ray diffraction",
            "emission line"
        ],
        "authors": [
            {
                "name": "jinli lai",
                "org": ""
            },
            {
                "name": "jianfeng sun",
                "org": ""
            },
            {
                "name": "d u haiyan",
                "org": ""
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2011
    },
    "kS0NQaZk": {
        "id": "kS0NQaZk",
        "title": "Luminescence properties of electron trapping material CaB 4O 7:Sm 3+",
        "abstract": "A novel electron trapping material of CaB4O7:Sm3+ was synthesized by high temperature solid-state reaction, and its characterization and luminescent properties were investigated at room temperature. The results indicate that ultraviolet light can be used as exciting source to store energy. After exposed under ultraviolet, the sample was stimulated by 980nm laser. As a result, an obvious luminescence at 556, 596 and 643 nm were detected. The photo-stimulated emission spectrum was three bands peaking at 562, 599 and 646 nm that are the characteristic emission of Sm3+ ions due to the f -> f transitions (4)G(5/2)-> 6H(J), (J = 5/2, 7/2, 9/2), respectively. The TL glow curve contains two overlapping glow peaks at around 541 and 598 K.",
        "keywords": [
            "electron trapping",
            "photo-stimulated luminescence",
            "optical storage materials"
        ],
        "authors": [
            {
                "name": "jia yue sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Wei Zhang",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "hai yan du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "PROGRESS IN NEW MATERIALS AND MECHANICS RESEARCH",
        "year": 2012
    },
    "XHc67jIx": {
        "id": "XHc67jIx",
        "title": "Preparation and characterization of upconversion nanocomposite for β-NaYF_4:Yb~(3+),Er~(3+)-supported TiO_2 nanobelts",
        "abstract": "Hexagonal NaYF4:Yb3+,Er3+ (β-NaYF4:Yb3+,Er3+) nanoparticles supported on TiO2 nanobelts were prepared using two-step pro- cedures of ion-exchangeable process and hydrothermal treatment: layered titanate nanobelts were first ion-exchanged with Y3+, Yb3+ and Er3+ cations to produce titanate nanobelts with these cations, and then, the product nanobelts in NaY solution were treated under hydrothermal con- dition to transform into anatase TiO2 nanobelts supported with β-NaYF4:Yb3+,Er3+ nanoparticles. The final products were characterized by various measurement techniques. Many preparation conditions, e.g., the content of added precursors, reaction time and pH value, were optimized to obtain nanocomposites including relatively uniform nanoparticles with strong upconversion (UC) emission intensity. The measurement results showed that the anatase TiO2 nanobelts, supported by the large number of β-NaYF4:Yb3+,Er3+ nanoparticles with 30–70 diameter range and very strong UC emission, could be achieved under suitable preparation condition. The UC emission intensity of the nanoparticles with the concentrations of Yb3+ and Er3+ closer to 20 mol.% and 1 mol.% was the strongest.",
        "keywords": [
            "tio2 nanobelt",
            "er3+",
            "nayf4:yb3+",
            "upconversion",
            "nanocomposites",
            "reaction time",
            "ion exchange"
        ],
        "authors": [
            {
                "name": "JI Tianhao",
                "org": ""
            },
            {
                "name": "YANG Fang",
                "org": ""
            },
            {
                "name": "DU Haiyan",
                "org": ""
            },
            {
                "name": "GUO Hong",
                "org": ""
            },
            {
                "name": "YANG Jianshi",
                "org": ""
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2010
    },
    "RFFTWrLQ": {
        "id": "RFFTWrLQ",
        "title": "Upconversion Luminescence Properties of NaYF_4∶Tm~(3+),Yb~(3+) Synthesized by Co-precipitation Method",
        "abstract": "The upconversion(UC) processes of infrared light to visible light of rare earth ions doped different hosts have been investigated extensively,due to their potential applications in some fields,such as solid-state lasers,display,communications,and so on.The recent researches emerging at the intersection of nanotech-nology and biotechnology are opening up a new period for the development of UC.As known,the controlled fabrication of a host with aimed structure is important for enhancing the upconversion efficiency,because the phonon energy of the host can affect the probabilities of non-radiative decay and the energy transfer.Therefore,it is necessary to choose a lattice with much lower phonon energy,which is benefit to the upconversion luminescence.Rare earth-doped hexagonal sodium yttrium fluoride(NaYF4) is a good host,which is known to be a very efficient near-infrared to visible upconverter.The hexagonal NaYF4 has low phonon energy.The structure of hexagonal phase gives rise to controversy about the cation sites and distribution.The trivalent thulium(Tm~(3+)) is an ideal candidate for single wavelength NIR upconversion due to its ladder of nearly equally spaced energy levels that are multiples of the 1G4→3H6 transition.The development of compact blue lasers based on Tm~(3+) upconversion processes is nowadays widely studied mainly due to the potential of high perfor-mance OEM applications,such as biomedical and analytical instrumentation,display,photoprinting.In thu-lium doped media,the efficiency of this process is very low,but it was noticed that the mechanism could be made one or two orders of magnitude more efficient by using ytterbium(Yb~(3+)).In this paper,trivalent thu-lium(Tm~(3+)) and yttebium(Yb~(3+)) ions codoped NaYF4 were synthesized by co-precipitation method.The concentration of Tm~(3+) and Yb~(3+) are 0.01%,0.1%,respectively.The absorption spectrum of NaYF4∶Tm~(3+),Yb~(3+) from 300 to 1 100 nm was measured at room temperature.The upconversion emission was observed when excited by 798 nm.The green and blue upconversion emission spectra were measured.Based on the experimental results the possible upconversion mechanism was analyzed.The main mechanism is the in-direct sensitization of Tm~(3+) and Yb~(3+).The blue emitting light results from the transition of 1G4→3H6 of Tm~(3+),green emitting light is from the transition of 1D2 →3F4 of Tm~(3+).To our knowledge,there have not been similar works published domestically and abroad.The structural properties of the samples were characterized by X-ray diffraction(XRD) and scanning electron microscopy(SEM).The results show that NaYF4∶Tm~(3+),Yb~(3+) prepared by co-precipitation method exhibits hexagonal crystal phase.",
        "keywords": [
            "NaYF4∶Tm~(3+)",
            "Yb~(3+)",
            "up-conversion luminescence",
            "indirect sensitization",
            "co-precipitation method"
        ],
        "authors": [
            {
                "name": "SUN Jia-yue",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "YANG Zhi-ping",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Luminescence",
        "year": 2009
    },
    "20Kvvd1i": {
        "id": "20Kvvd1i",
        "title": "Photoluminescence properties and energy transfer of Ce 3+, Eu 2+ co-doped Sr 3Gd(PO 4) 3 phosphor",
        "abstract": "Novel Ce 3+- and Eu 2+-coactivated Sr 3Gd(PO 4) 3 phosphors were prepared by high temperature solid-state reactions. The Sr 3Gd(PO 4) 3:Ce 3+,Eu 2+ phosphor showed two emission bands under 310 nm excitation: the one observed at 374 nm was assigned to the 4f 05d 1 → 4f 1 transition of Ce 3+ ion emission, and the other found at 518 nm was attributed to the 4f 65d 1 → 4f 7 transition of Eu 2+ ions. The energy transfer from Ce 3+ to Eu 2+ in Sr 3Gd(PO 4) 3 host matrix was studied and demonstrated to be a resonant type via a dipole-quadrupole mechanism. Furthermore, we have calculated the critical distance for Ce 3+ → Eu 2+ energy transfer to be about 32.02 by the concentration- quenching method. Preliminary results indicate that the phosphor might be a promising green phosphor for UV-based white LEDs. © 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Chemical synthesis",
            "Optical properties",
            "Rare earth alloys and compounds",
            "X-ray diffraction"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2012
    },
    "YhxiB2pl": {
        "id": "YhxiB2pl",
        "title": "Preparation of non-grinding CaAl_2O_4:Eu~(2+),Dy~(3+) blue long afterglow material by microwave combustion method",
        "abstract": "Dispersant,comburent,frother,and mineralizer were added in the system successively.The non-grinding long afterglow material CaAl2O4:Eu~(2+),Dy~(3+) was prepared by combusting in home microwave oven directly.XRD analysis showed that the powders were nearly pure CaAl_2O_4 with very little other phases,the size of the grain was 41.5nm.FS results indicated that there were 2 excitation peaks marked 264.1nm and 324.8nm,and the emission peak located at 441.2nm,afterglow lasted up to several hours.Microwave combustion-frothing method needs less time,low temperature and no grinding process,and the material has good luminescent property.",
        "keywords": [
            "blue",
            "non-grinding",
            "long afterglow",
            "microwave combustion method",
            "Dy~(3+)",
            "CaAl_2O_4:Eu~(2+)"
        ],
        "authors": [
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Li Gengshen",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2006
    },
    "V1dXEn6I": {
        "id": "V1dXEn6I",
        "title": "Effect of trivalent rare earth ions doping on the fluorescence properties of electron trapping materials SrS:Eu~(2+)",
        "abstract": "Trivalent rare-earth ions (La3+,Pr3+,Nd3+,Sm3+,Gd3+,Tb3+,Dy3+,Ho3+,Er3+,Tm3+,and Yb3+) were investigated as the codoped auxiliary sensitizer for the electron trapping materials SrS:Eu2+ in order to enhance the fluorescence properties.It was found that Sm3+ and Tb3+ had the best photoluminescence stimulated luminescence (PSL) effect among the selected trivalent rare-earth ions.All the SrS:Eu2+ samples doped by different trivalent rare-earth ions could be stimulated by 980 nm laser after being exposed to the conventional sunlight,and they emitted PSL with the peak located at 615 nm.The result also indicated that some co-doped rare earth ions could increase fluorescence intensities of the traditional electron trapping materials SrS:Eu2+.",
        "keywords": [
            "photo-stimulated luminescence",
            "electron trapping effect",
            "optical storage materials",
            "rare earths",
            "optical storage"
        ],
        "authors": [
            {
                "name": "SUN Jiayue",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "LIU Zhenxing",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Haiyan",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2011
    },
    "2gE7U32i": {
        "id": "2gE7U32i",
        "title": "Synthesis and luminescence properties of novel LiSrPO 4:Dy 3+ phosphor",
        "abstract": "Novel LiSrPO 4:Dy 3+ phosphors for white light-emitting diodes (w-LEDs) were synthesized by the conventional solid-state reaction. X-ray powder diffraction (XRD) analysis confirmed the phase formation of LiSrPO 4:Dy 3+ materials. Luminescence properties results showed that the phosphor could be efficiently excited by the UV-vis light region from 250 to 460 nm, and it exhibited blue (483 nm) and yellow (574 nm) emission corresponding to 4F 9/2 → 6H 15/2 transitions and 4F 9/2 → 6H 13/ 2 transitions, respectively. The luminescence intensity of LiSrPO 4:xDy 3+ phosphor firstly increased and then decreased with increasing Dy 3+ concentration, and reached the maximum at x = 0.03. It was found that concentration quenching occurred as a result of dipole-dipole interaction according to the Dexter's theory. The decay time was also determined for various concentrations of Dy 3+ in LiSrPO 4. © 2011 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "a. optical materials",
            "c. x-ray diffraction",
            "d. optical properties",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2011
    },
    "ODBbqPXr": {
        "id": "ODBbqPXr",
        "title": "Preparation and Characterization of Cr_2O_3 System Optically Variable Pigments",
        "abstract": "The optically variable pigments were produced by wet chemical method, and Ti coated mica having interference colors acted as host materials. The phase of the pigment was characterized by XRD, and its optically variable effect was investigated by X-Rite MA86Ⅱ five angles spectrophotometer. The impact of different interference host materials on improving the color travel effect were studied, and the influence of white and black background on the hue and the color travel effect were researched, there are existing relationship between color travel effects. The results showed that optically variable pigments can be prepared by coating Cr_2O_3 on the pretreated Ti coated mica, by changing different host the color travel effect is changed, different backgrounds will influence the pigments' hue and the color travel effect.",
        "keywords": [
            "Optically variable",
            "Wet chemical method",
            "Pigments",
            "Cr_2O_3"
        ],
        "authors": [
            {
                "name": "Du Haiyan",
                "org": ""
            },
            {
                "name": "Chen Qirong",
                "org": ""
            },
            {
                "name": "Sun Jiayue",
                "org": ""
            },
            {
                "name": "Xu Wencai",
                "org": ""
            },
            {
                "name": "Ma Erjun",
                "org": ""
            }
        ],
        "venue": "Chemistry",
        "year": 2006
    },
    "l0pvIhZ7": {
        "id": "l0pvIhZ7",
        "title": "Synthesis and luminescence properties of Gd 6 MoO 12 :Yb 3+ , Er 3+ phosphor with enhanced photoluminescence by Li + doping",
        "abstract": "",
        "keywords": [
            "phosphor"
        ],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "bing xue",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Infrared Physics & Technology",
        "year": 2013
    },
    "Tvd4H7a8": {
        "id": "Tvd4H7a8",
        "title": "Synthesis and two-color emission properties of BaGd2(MoO4)4:Eu3+,Er3+,Yb3+ phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "wei zhang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2012
    },
    "hAB3leut": {
        "id": "hAB3leut",
        "title": "Optical storage phosphor SrS:Eu 2+, Sm 3+ synthesized by hydrothermal method",
        "abstract": "Optical storage phosphor SrS:Eu 2+, Sm 3+ were prepared by hydrothermal method.The phase structure, microstructure and photo-stimulated luminescence spectra were characterized by XRD, SEM, EDAX, PSL, respectively.The results indicated that the SrS:Eu 2+, Sm 3+ were of pure phase, face-centred cubic structure and had small size with narrow distribution.It is found that the impurity content hydrothermal method can be effectively decreased and the speed of decay can be slow down.Photo-stimulation luminescence spectra(λ ex=980nm)showed that Eu 2+ and Sm 3+ could be incorporated into SrS effectively, and the luminescence intensity of the SrS:Eu 2+, Sm 3+ samples obtained by hydrothermal process were higher than the high temperature solid state method.",
        "keywords": [
            "Hydrothermal process",
            "Optical storage phosphor",
            "SrS"
        ],
        "authors": [
            {
                "name": "SUN Jia-yue",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "SUN Ran-di",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2011
    },
    "srBQEQqY": {
        "id": "srBQEQqY",
        "title": "Luminescence properties of a new red emitting Eu~(3+)-doped alkaline-earth fluoborate phosphor: BaCa_(1–2x)BO_3F:xEu~(3+), xM~+ (M=Li, Na, K)",
        "abstract": "A series of new red-emitting BaCa1–2xBO3F:xEu3+, xM+ (M=Li, Na, K) phosphors were synthesized by the solid-reaction method. X-ray diffraction (XRD), diffuse reflection (UV-vis) and photoluminescence spectra were utilized to characterize the crystallization process, structure and luminescence properties of the as-synthesized phosphors. The XRD results indicated that the sample began to crystallize at 800 oC, and single-phase BaCaBO3F was fully obtained after annealing at 1000 oC. The charge compensated behaviors were investigated in this paper by considering different cations like Li+, Na+ and K+ acting as the charge compensator. The as-prepared phosphors had better emission properties, and the two characteristic emission lines peaking at 590 and 615 nm could be obtained upon 394, 463 and 532 nm excitation with the chromaticity coordinates of (0.596, 0.391), which were due to 5D0–7F1 and 5D0–7F2 transitions of Eu3+ ions. Further, the concentration quenching and corresponding luminescence mechanisms of BaCa1–2xBO3F:xEu3+, xNa+ phosphors were also discussed.",
        "keywords": [
            "fluoborate",
            "phosphor",
            "charge compensator",
            "rare earths"
        ],
        "authors": [
            {
                "name": "SUN Jiayue",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "LAI Jinli",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "SUN Jianfeng",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            },
            {
                "name": "DU Haiyan",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing , China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2011
    },
    "29mR6avj": {
        "id": "29mR6avj",
        "title": "The Wet Chemical Preparation and Examination of the Angle-dependent Interference Pigments",
        "abstract": "The angle-dependent interference pigments use different materials as substrates,on which many kinds of metal dioxides and organic dyes are coated,so the pigments which are observed from the different angle gain different colours.This article introduced the optically basic theory,chemistry preparation methods in liquid phase and examination of the angle-dependent interference pigments coated on titanium-mica.It has reviewed the development of the multicoated angle-dependent pigments, proposed the emphasis of future research and development.",
        "keywords": [
            "examination",
            "optically basic theory",
            "angle-dependent interference pigments",
            "preparation methods"
        ],
        "authors": [
            {
                "name": "LIU Cai-xia",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "ZHANG Zi-yin",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "XU Wen-cai",
                "org": "Laboratory of Printing & Packing Material and Technology Beijing Area Major Laboratory,Beijing ,China"
            },
            {
                "name": "MA Er-jun",
                "org": "Laboratory of Printing & Packing Material and Technology Beijing Area Major Laboratory,Beijing ,China"
            }
        ],
        "venue": "Bulletin of the Chinese Ceramic Society",
        "year": 2007
    },
    "wGEcB27c": {
        "id": "wGEcB27c",
        "title": "The influence of Dy3+in the novel electron trapping materials (ETM) SrS: Eu2+, Dy3+",
        "abstract": "A new electron trapping materials (ETM) SrS: Eu2+, Dy 3+, which was prepared by the method of high temperature solid-state reaction. The results indicate that both ultraviolet light and visible light can be used as exciting source to store energy. After exposed under ultraviolet, the sample was stimulated by 980nm laser. As a result, an obvious luminescence at 615 nm was detected. The up-conversion emission spectrum was found to be a continuous broadband spectrum resulted from the multi-transitions of Eu 2+ 4f6→4f7 (8S7/2). The emission peak intensity of SrS: Eu2+, Dy3+ was stronger than SrS: Eu2+. © (2011) Trans Tech Publications.",
        "keywords": [
            "Electron trapping material",
            "Rare earth ions",
            "SrS: Eu2+",
            " Dy 3+"
        ],
        "authors": [
            {
                "name": "Jia Y. Suna",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhenxing Liu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "1pHINv5H": {
        "id": "1pHINv5H",
        "title": "White upconverted luminescence of Ho 3+ /Yb 3+ /Tm 3+ tri-doped Gd 2 Mo 3 O 9 phosphors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "bing xue",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Materials Science and Engineering B-advanced Functional Solid-state Materials",
        "year": 2013
    },
    "1JUNuWGJ": {
        "id": "1JUNuWGJ",
        "title": "Luminescence Properties of Ba[sub 2]Mg(BO[sub 3])[sub 2]:Eu[sup 2+] Red Phosphors Synthesized by a Microwave-Assisted Sol-Gel Route",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": ""
            },
            {
                "name": "Jianfeng Sun",
                "org": ""
            },
            {
                "name": "Zhiguo Xia",
                "org": ""
            },
            {
                "name": "Jiayue Sun",
                "org": ""
            }
        ],
        "venue": "Journal of The Electrochemical Society",
        "year": 2009
    },
    "sBpuWh5S": {
        "id": "sBpuWh5S",
        "title": "Hydrothermal synthesis of SrF2:Yb3+/Er3+ micro-/nanocrystals with multiform morphologies and upconversion properties",
        "abstract": "Micro- and nanocrystals cubic-phase SrF2:Yb3+/Er 3+ upconversion luminescence phosphors were synthesized via a facile hydrothermal route in the presence of different surfactants. The samples were characterized with X-ray diffraction (XRD), Fourier transform infrared spectra (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and upconversion emission spectra. As-prepared products showed a variety of morphologies, such as cubic-shaped microcrystal, hierarchical structure microspheres, spherical-shaped nanocrystals and nanosheets. The intrinsic structural feature of cubic-phase SrF2 and two important external factors, namely, the surfactants in the reaction solution and fluoride sources, were responsible for shape determination of SrF2:Yb 3+/Er3+. The possible formation mechanisms for products with various architectures were presented. A systematic study on the photoluminescence of Yb3+/Er3+-doped SrF2 samples with cubic shape, microspheres, spherical and nanosheets shapes showed that the optical properties of these products were strongly dependent on their morphologies and size. © 2011 The Chinese Society of Rare Earths.",
        "keywords": [
            "morphology",
            "rare earths",
            "SrF2:Yb3+/Er3+",
            "surfactant",
            "upconversion"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianbo B. Xian",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2011
    },
    "M0AXsjDA": {
        "id": "M0AXsjDA",
        "title": "Synthesis and characterization of nanosized phpsphor SrS:Eu 2+,Sm 3+ by a hydrothermal process",
        "abstract": "Electron trapping materials SrS:Eu2+,Sm3+ were prepared by hydrothermal method at 200 degrees C for 5 h. The phase structure, microstructure and optical properties were characterized by XRD, SEM, EDAX, PL, PSL, and TL, respectively. The sample was stimulated by a 980 nm infrared laser after exposing to the sun light, It can be seen that the PSL emission spectra was a band spectrum with one peak at 605 nm, and this emission was ascribed to characteristic 5d -> 4f transition of Eu2+, and the photo stimulated luminescence phenomenon was observed.",
        "keywords": [
            "SrS:Eu2+",
            "Sm3+",
            "nanosized phpsphor",
            "hydrothermal process"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Randi Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "MANUFACTURING SCIENCE AND TECHNOLOGY, PTS 1-3",
        "year": 2011
    },
    "vNqb5RTa": {
        "id": "vNqb5RTa",
        "title": "Last Decade Progress for Synthesis of the Pyruvic Acid and Pyruvate",
        "abstract": "Progress in research on the synthesis of pyruvic acid and pyruvate during the last decade was reviewed.Various synthesis ways,including tartaric method,lactate oxidation,fermentative production and enzymatic catalyst,were introduced.Also the principle parameter and yield of synthesis methods were setted forth to tell their potential.",
        "keywords": [
            "pyruvic acid pyruvate synthesis"
        ],
        "authors": [
            {
                "name": "Zhang Hua",
                "org": ""
            },
            {
                "name": "Du Haiyan",
                "org": ""
            },
            {
                "name": "Sun Jiayue",
                "org": ""
            },
            {
                "name": "Li Ning",
                "org": ""
            }
        ],
        "venue": "Chemical Industry Times",
        "year": 2006
    },
    "yZnJ37wB": {
        "id": "yZnJ37wB",
        "title": "Preparation and characterization of Ti1−xZrxO2/ZrO2 nanocomposite",
        "abstract": "Hierarchical Ti 1 − x Zr x O 2 /ZrO 2 nanocomposite was prepared by a hydrothermal method through a combination of the sol–gel process and co-precipitation from tetrabutyl titanate and ZrOCl 2 . Structures and properties were characterized by various measurement techniques. It was demonstrated that the products with a radial shape and a large specific surface area had superhydrophilicity and high photocatalytic activity. X-ray diffraction and energy-dispersive X-ray measurement analysis indicated that the Zr 4+ ions were incorporated into the anatase TiO 2 lattice. Keywords Hydrothermal method Nanocomposite Titania Zirconia Doping",
        "keywords": [],
        "authors": [
            {
                "name": "Li Wang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Fang Yang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Tianhao Ji",
                "org": ""
            },
            {
                "name": "Qinglin Yang",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Xingyi Qi",
                "org": "School of Materials Science and Technology, Beijing University of Aeronautics and Astronautics, Beijing 100083, China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, China"
            },
            {
                "name": "Jiayue Sun",
                "org": "College of Chemical and Environmental Engineering, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100037, China"
            }
        ],
        "venue": "Scripta Materialia",
        "year": 2008
    },
    "mvmfqzHS": {
        "id": "mvmfqzHS",
        "title": "Luminescence properties of SrB_4_O_7:Sm~(2+) for light conversion agent",
        "abstract": "A deep red-emitting SrB4O7:Sm2+ phosphor for light conversion agent was synthesized by the conventional solid-state reaction. X-ray powder diffraction (XRD) analysis confirmed the phase formation of SrB4O 7:Sm2+ materials. Results of luminescence properties showed that the phosphor could be efficiently excited by the UV-vis light region from 250–500 nm, and it exhibited deep red (685 nm) emission corresponding to 5D0 → 7F0 transition of Sm 2+ . The critical quenching concentration of Sm 2+ in SrB4O7 :Sm 2+ phosphor was about 0.05, and the corresponding concentration quenching mechanism was verified to be the dipole-dipole interaction according to the Dexter’s theory. The decay times had few alterations with different concentrations in SrB4O7:xSm 2+ phosphor.",
        "keywords": [
            "sm~(2+)",
            "light conversion agent",
            "photoluminescence",
            "rare earths"
        ],
        "authors": [
            {
                "name": "SUN Jiayue",
                "org": "School of Sciences,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "ZHU Jicheng",
                "org": "School of Sciences,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "LIU Xiaotang",
                "org": " College of Sciences,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "DU Haiyan",
                "org": "School of Sciences,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2012
    },
    "dYvEX6rc": {
        "id": "dYvEX6rc",
        "title": "Preparation and characterization of Cr<sub>2</sub>O<sub>3</sub> system optically variable pigment",
        "abstract": "An optically variable pigment was produced by wet chemical method, where TiO2-coated mica with interference colors acted as the substrate materials. The structure of the pigment was characterized by\n X-ray diffraction (XRD), and its optically variable effect was investigated by X-Rite MA86 II five angles spectrophotometer.\n The impact of different interference substrate materials for improving the color travel effect was studied, and the influence\n of white and black background on the hue and the color travel effect were studied. Results showed that optically variable\n pigments can be prepared by coating Cr2O3 on the surface of the pretreated TiO2-coated mica. The color travel effect was sensitive to the change of substrate materials, and different backgrounds can influence\n the hue and the color travel effect of the pigment.",
        "keywords": [
            "wet chemical method",
            "optically variable",
            "cr2o3",
            "pigment"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology and Business University College of Chemical and Environmental Engineering Beijing 100037 China"
            },
            {
                "name": "Hua Zhang",
                "org": "Beijing Technology and Business University College of Chemical and Environmental Engineering Beijing 100037 China"
            },
            {
                "name": "Qirong Chen",
                "org": "Beijing Technology and Business University College of Chemical and Environmental Engineering Beijing 100037 China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology and Business University College of Chemical and Environmental Engineering Beijing 100037 China"
            },
            {
                "name": "Wencai Xu",
                "org": "Beijing Area Major Laboratory Laboratory of Printing and Packaging Material and Technology Beijing 102600 China"
            },
            {
                "name": "Erjun Ma",
                "org": "Beijing Area Major Laboratory Laboratory of Printing and Packaging Material and Technology Beijing 102600 China"
            }
        ],
        "venue": "Frontiers of Chemistry in China",
        "year": 2007
    },
    "cHbzfyuB": {
        "id": "cHbzfyuB",
        "title": "Facile room temperature synthesis of SrSO4:RE (RE = Sm 3+, Tb3+, Ce3+) microrods via a precipitation method and its luminescence properties",
        "abstract": "Three SrSO4:RE phosphors activated with rare-earth ions (RE = Sm3+, Tb3+ and Ce3+) were synthesized by a facile precipitation reaction without using any surfactants or templates. Especially, rod-like SrSO4 microcrystals with size of about 14 μm length and 6 μm width can be obtained under ambient condition at room temperature. The phase structure, microstructure and luminescence properties were characterized. In the photoluminescence property investigation of SrSO 4:Ce3+, two overlapping bands with peaks at 301 and 320 nm due to Ce3+ were observed. Narrow bands observed in emission spectra and excitation spectra of SrSO4:RE (RE = Sm3+ and Tb 3+) phosphors were well identified with the electronic transitions within the 4fn (n = 5 and 8) configurations of RE3+. © 2013 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "B. Chemical synthesis",
            "C. X-ray diffraction",
            "D. Microstructure"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Guangchao Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2013
    },
    "EiuRpxH7": {
        "id": "EiuRpxH7",
        "title": "Preparation and characterization of Co-Ti system optically variable pigments",
        "abstract": "The optically variable pigments were produced by wet chemical method,and mica titanium having interference colors acted as host materials.The phase of the pigment was characterized by XRD, and its optically variable effect was investigated by CIE chromatic coordinate,and X-Rite MA86Ⅱ five angles spectrophotometer.The impact of pretreatment of mica titanium and the experiment conditions on improving the color travel effect were studied,there are relation between color travel effect.The results showed that optically variable pigments can be prepared by coating CoO on the pretreated mica titanium,the reaction temperature is between 70℃ to 80℃,the pH is between 9.5 to 10.5,the feeding rate is between 2 to 3 drop per minute,the calcine temperature is 900℃ and the time is 60min,and optically variable pigments with different colors can be produced by changing different host,changing the viewing angle the pigments′ hue and the color travel effect were changed.",
        "keywords": [
            "mica titanium",
            "optically variation",
            "wet chemical method",
            "pigment"
        ],
        "authors": [
            {
                "name": "Chen Qirong",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Xiao Yang",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2006
    },
    "ZoQLwXEt": {
        "id": "ZoQLwXEt",
        "title": "Progress of research of chemical light",
        "abstract": "Chemical light is an new organic luminescent material.This paper introduced the characteristic,structure,composition and some factors affecting the chemical light.The synthesis and application of oxalate ester and fluorescence agent are also introduced.There are 38 literatures.",
        "keywords": [
            "fluorescence agent",
            "chemiluminescence",
            "chemical light",
            "synthesis",
            "oxalate ester"
        ],
        "authors": [
            {
                "name": "Xu Min",
                "org": "Applied Chemistry Department,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "Applied Chemistry Department,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "Applied Chemistry Department,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Zhao Jin",
                "org": "Applied Chemistry Department,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2006
    },
    "PK2ktQ5m": {
        "id": "PK2ktQ5m",
        "title": "Phase structure and temperature dependent luminescence properties of Sr2LiSiO4F:Eu2+ and Sr2MgSi 2O7:Eu2+ phosphors",
        "abstract": "Green-emitting Sr2LiSiO4F:Eu2+ and blue-emitting Sr2MgSi2O7:Eu2+ phosphors were synthesized by the conventional high temperature solid-state route, respectively. Their structures and photoluminescence properties were comparatively investigated. It was found that the mixture phases of Sr 2MgSi2O7 and SrF2 were obtained when a part of Sr2+ in Sr2LiSiO4F was replaced by some amount of Mg2+ in order to design the possible SrMgLiSiO 4F:Eu2+ phosphor. Based on the photoluminescence analysis, Sr2LiSiO4F:Eu2+ phosphor exhibited a green broad emission band of main peak at 513 nm under the excitation of 365 nm, while the Sr2MgSi2O7:Eu2+ and SrMgLiSiO4F:Eu2+ phosphor showed blue emission centered at 467 nm. The temperature dependent photoluminescence properties and room temperature decay time for the three kinds of phosphors were also discussed in this paper. © 2010 The Chinese Society of Rare Earths.",
        "keywords": [
            "Chlorosilicate",
            "Phosphor",
            "Rare earths",
            "White LED"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Libing Liao",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Rare Earths",
        "year": 2010
    },
    "kpeanSkK": {
        "id": "kpeanSkK",
        "title": "Synthesis and luminescence properties of novel Y2Si 4N6C:Sm3+ carbonitride phosphor",
        "abstract": "Novel Y2Si4N6C:Sm3+ phosphors for white light-emitting diodes (w-LEDs) were prepared by a carbothermal reduction and nitridation method. X-ray diffraction (XRD) and photoluminescence spectra were utilized to characterize the structure and luminescence properties of the as-synthesized phosphors. The emission spectrum obtained by excitation into 291 nm contains exclusively the characteristic emission of Sm3+ at 568, 607 and 654 nm which correspond to the transitions from 4G5/2 to 6H5/2, 6H 7/2, and 6H9/2 of Sm3+, respectively. The strongest one is located at 607 nm due to 4G 5/2-6H7/2 transition of Sm3+. It was found that concentration quenching occurred as a result of dipole-dipole interaction according to Dexter's theory. The temperature dependence of photoluminescence properties was investigated from 25 to 300 °C and the prepared Y2Si4N6C:Sm3+ phosphors showed superior thermal quenching properties. © 2012 Elsevier Ltd and Techna Group S.r.l.",
        "keywords": [
            "Luminescence",
            "Optical materials",
            "Red phosphors",
            "W-LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2013
    },
    "Zlor4BFs": {
        "id": "Zlor4BFs",
        "title": "Hydrothermal synthesis of SrF_2:Yb~(3+)/Er~(3+) micro-/nanocrystals with multiform morphologies and upconversion properties",
        "abstract": "Micro-and nanocrystals cubic-phase SrF2:Yb3+/Er3+ upconversion luminescence phosphors were synthesized via a facile hydro-thermal route in the presence of different surfactants.The samples were characterized with X-ray diffraction (XRD),Fourier transform infra-red spectra (FT-IR),scanning electron microscopy (SEM),transmission electron microscopy (TEM),and upconversion emission spectra.As-prepared products showed a variety of morphologies,such as cubic-shaped microcrystal,hierarchical structure microspheres,spheri-cal-shaped nanocrystals and nanosheets.The intrinsic structural feature of cubic-phase SrF2 and two important external factors,namely,the surfactants in the reaction solution and fluoride sources,were responsible for shape determination of SrF2:Yb3+/Er3+.The possible formation mechanisms for products with various architectures were presented.A systematic study on the photoluminescence of Yb3+/Er3+-doped SrF2 samples with cubic shape,microspheres,spherical and nanosheets shapes showed that the optical properties of these products were strongly dependent on their morphologies and size.",
        "keywords": [
            "morphology",
            "surfactant",
            "upconversion",
            "rare earths",
            "srf2:yb3+/er3+",
            "scanning electron microscopy",
            "x ray diffraction",
            "transmission electron microscopy"
        ],
        "authors": [
            {
                "name": "SUN Jiayue",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "XIAN Jianbo",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "ZHANG Xiangyan",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Haiyan",
                "org": "College of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "稀土学报(英文版)",
        "year": 2011
    },
    "HrZ7xCTc": {
        "id": "HrZ7xCTc",
        "title": "Preparation and characterization of hexagonal WO 3 nanobelts",
        "abstract": "Hexagonal WO 3 nanobelts were prepared using appropriate amounts of Na 2W0 4, K 2S0 4, and H 2C 20 4 by two-step hydrothermal procedure. Based on the investigation of the pH value, the added content of K 2S0 4, reaction temperature and time as well as different surfactants, the synthesis condition of precursor nanobelts and formation mechanism were suggested. Using the precursor nanobelts, hexagonal W0 3 nanobelts can be obtained under the second hydrothermal treatment. The measurement results show that the W0 3 nanobelts with 100~300 nm of width and many micrometers of length keep very well.",
        "keywords": [
            "Formation mechanism",
            "Hexagonal wo 3 nanobelts",
            "Hydrothermal preparation"
        ],
        "authors": [
            {
                "name": "JI Tian-Hao",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "HOU Shao-Fan",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            },
            {
                "name": "DU Hai-Yan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "SUN Jia-Yue",
                "org": "Beihang University(Beijing University of Aeronautics and Astronautics,Beihang University),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of Inorganic Chemistry",
        "year": 2009
    },
    "qxykduw2": {
        "id": "qxykduw2",
        "title": "The luminescence properties of BaGd2(MoO4) 4: Eu3+, Er3+, Yb3+ phosphors",
        "abstract": "Two-color emission phosphors BaGd2(MoO4)4: Eu3+, Er3+, Yb3+ have been synthesized by the high temperature solid-state method. The as-prepared BaGd2(MoO 4)4: Eu3+, Er3+, Yb3+ phosphors can emit intense red light under 395 nm UV excitation, while it will show bright green light upon 980 nm infrared light excitation. It is found that the red emission peaks at 595 and 614 nm should be attributed to 5D0-7F1 and 5D 0-7F2 transitions of Eu3+, respectively. The green emission peaks centered at 532 and 553 nm under 980 nm excitation, are attributed to Er3+ transitions from 4H11/2-4I15/2 and 4S 3/2-4I15/2, respectively. © (2011) Trans Tech Publications.",
        "keywords": [
            "energy transfer",
            "luminescence materials",
            "upconversion luminescence"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "WeiHang Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Yujing Lan",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "QrKk17BO": {
        "id": "QrKk17BO",
        "title": "Research status and prospect of upconversion luminescence materials and luminescence efficiency",
        "abstract": "The research progress of upconversion luminescence materials were summarized,the basic mechanisms of upconversion luminescence and the sorts of upconversion luminescence materials were introduced.The factors affecting the luminescence efficiency was analyzed.The development of upconversion luminescence materials were prospected.",
        "keywords": [
            "luminescence material",
            "rare earth ion",
            "upconversion"
        ],
        "authors": [
            {
                "name": "Du Haiyan",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Yang Zhiping",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "School of Chemical Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2009
    },
    "1uLXBAmU": {
        "id": "1uLXBAmU",
        "title": "Effect of deputy group metal ions on the fluorescent properties of the CPPO-H2O2-Rhodamine B system",
        "abstract": "The influence of metal ions on the peroxyoxalate chemiluminescence reaction was investigated. A number of metal ions showed the quenching effect of the chemiluminescence reaction of bis (3, 5, 6- trichloro-2-carbopentyloxy) oxalate with hydrogen peroxide in the presence of Rhodamine B as the fluorophore. Copper ion gave the highest quenching effect. The reason for the decrease in the chemiluminescence intensity by metal ions is probably a change in the conjugative structure of Rhodamine B due to combination of metal ions and Rhodamine B. © (2011) Trans Tech Publications.",
        "keywords": [
            "chemiluminescence",
            "metal eons",
            "peroxyoxalate",
            "rhodamine b"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Weida Xu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Wei Zhou",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Materials Science Forum",
        "year": 2011
    },
    "lxMlDmAF": {
        "id": "lxMlDmAF",
        "title": "Luminescence properties and energy transfer investigations of Sr 3Gd(PO4)3:Ce3+,Tb3+ phosphors",
        "abstract": "Ce3+ and Tb3+ co-doped Sr3Gd(PO 4)3 phosphors were synthesized by the solid-state method. The phase structure and luminescence properties of the phosphor samples were characterized by using powder X-ray diffraction (XRD), photoluminescence (PL) excitation and emission spectra, decay time, respectively. The obtained phosphor exhibits a strong excitation band between 200 and 400 nm, matching well with the dominant emission band of a ultraviolet (UV) light-emitting-diode (LED) chip. Effective energy transfer occurred from Ce3+ to Tb3+ in Sr3Gd(PO4)3 hosts due to the spectra overlap between the PL emission spectrum of Ce3+ ion and the PL excitation spectrum of Tb3+ ion. The energy transfer from Ce 3+ and Tb3+ in Sr3Gd(PO4) 3 host was demonstrated to be resonant type via a dipole-dipole interaction mechanism with the energy transfer critical distance of 1.87 nm. Furthermore, Sr3Gd(PO4)3:Ce3+, xTb3 can be systematically tuned to generate blue light to yellow-greenish light under UV excitation. It can serve as a potential color-tunable UV phosphor for white-light LED (w-LEDS) devices. © 2013 Elsevier Ltd.",
        "keywords": [
            "A. Optical materials",
            "C. X-ray diffraction",
            "D. Luminescence"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": " Junhuizeng",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Physics and Chemistry of Solids",
        "year": 2013
    },
    "upQ6NNpr": {
        "id": "upQ6NNpr",
        "title": "Preparation and characterization of Cr2O3 system optically variable pigments",
        "abstract": "An optically variable pigment was produced by wet chemical method, where TiO2-coated mica with interference colors acted as the substrate materials. The structure of the pigment was characterized by X-ray diffraction (XRD), and its optically variable effect was investigated by X-Rite MA86 II five angles spectrophotometer. The impact of different interference substrate materials for improving the color travel effect was studied, and the influence of white and black background on the hue and the color travel effect were studied. Results showed that optically variable pigments can be prepared by coating Cr2O3 on the surface of the pretreated TiO 2-coated mica. The color travel effect was sensitive to the change of substrate materials, and different backgrounds can influence the hue and the color travel effect of the pigment. © 2007 Higher Education Press and Springer-Verlag.",
        "keywords": [
            "cr2o3",
            "optically variable",
            "pigments",
            "wet chemical method"
        ],
        "authors": [
            {
                "name": "haiyan du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "hua zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Qirong Rong Chen",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "jiayue sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "wencai xu",
                "org": "Beijing Area Major Laboratory(Beijing Area Major Laboratory,Major Laboratory),Beijing,China"
            },
            {
                "name": "erjun ma",
                "org": "Beijing Area Major Laboratory(Beijing Area Major Laboratory,Major Laboratory),Beijing,China"
            }
        ],
        "venue": "Chemistry Bulletin / Huaxue Tongbao",
        "year": 2006
    },
    "8rCl4OhX": {
        "id": "8rCl4OhX",
        "title": "Structure and upconversion luminescence properties of BaYF 5 :Yb 3+ , Er 3+ nanoparticles prepared by different methods",
        "abstract": "",
        "keywords": [
            "upconversion"
        ],
        "authors": [
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "weihang zhang",
                "org": ""
            },
            {
                "name": "jiayue sun",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2011
    },
    "UsdOUvwb": {
        "id": "UsdOUvwb",
        "title": "Synthesis and analysis of novel solid state lighting compound Ca 3SiO 4Br 2:Eu 2+",
        "abstract": "Novel blue-emitting material, Eu 2+-doped Ca 3SiO 4Br 2 was reported in this paper. Flaky crystals of Ca 3SiO 4Br 2 were grown out of high-temperature Ca 2SiO 4/CaBr 2 melts. The crystal structure was determined as the chemical composition of Ca 3SiO 4Br 2, and structural investigations have also shown that Ca 3SiO 4Br 2 is composed of the layers of calcium chloride and dicalcium silicate. Based on the photoluminescence analysis, Ca 3SiO 4Br 2:Eu 2+ phosphor exhibited a broad blue emission band of main peak at 470 nm under the near ultraviolet (n-UV) light (300~450 nm), and efficient n-UV absorption property can be testified by UV-Vis diffuse reflectance spectra. It indicated that halosilicate materials Ca 3SiO 4Br 2:Eu 2+ phosphor is an excellent phosphor in the application of the white LEDs.",
        "keywords": [
            "Blue emission phosphor",
            "Crystal structure",
            "Halosilicate",
            "Rare earth luminescence",
            "White light LED lighting"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "GuoWu Li",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Ming Xiong",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Faguang Xuebao/Chinese Journal of Luminescence",
        "year": 2011
    },
    "7JlLOG2I": {
        "id": "7JlLOG2I",
        "title": "A novel blue-emitting Ca2B5O9Br:Eu2+ phosphor prepared by a microwave calcination route",
        "abstract": "A blue-emitting Ca 2 B 5 O 9 Br:Eu 2+ phosphor for white light-emitting diodes was synthesized via a microwave calcination route. The phosphor powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and fluorescence spectrophotometer, respectively. The obtained results revealed that the Ca 2 B 5 O 9 Br:Eu 2+ phosphor prepared by the microwave calcination route possessed a rod-like morphology with the single phase orthorhombic structure. Based on the photoluminescence analysis, it was found that Ca 2 B 5 O 9 Br:Eu 2+ phosphor exhibited a broad excitation band chiefly in the near ultraviolet region (270–420 nm) and a blue broad emission band of main peak at 452 nm under the strongest excitation of 411 nm. Further investigation on concentration-dependent emission spectra indicated that Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor exhibited the strongest luminescent intensity, and the concentration quenching for the two Eu-site emission centers was caused by dipole–dipole interactions. Keywords Optical materials Optical properties 1 Introduction Nowadays, increasing interests have been focused on GaN/InGaN-based white light-emitting diodes (LEDs) [1,2] . Among them, there are several ways to obtain the phosphor-converted white LEDs. One scheme is the combination of the blue LEDs chip and the yellow-emitting phosphor, and the other is the combination of the near ultraviolet (n-UV) LEDs chip and the red, green and blue emission phosphor [3,4] . In order to fulfill the corresponding requirements, many research papers on developing new phosphor systems used as light-conversion phosphors for white LEDs have been reported [5–10] . Among them, the studies on halo-based materials, such as halophosphate phosphors [7] , haloborate phosphors [8] , halosilicate phosphor [9] and haloaluminate phosphors [10] , become a hot issue in exploring new phosphor materials, and they have also been proved to be efficient in the application of the white LEDs light-conversion phosphors. During the process of the exploration in haloborate-based light-conversion phosphors for white LEDs, Yang [8] recently reported the yellow-emitting phosphor Ca 2 BO 3 Cl:Eu 2+ , and Zhang [11] investigated the red-emitting phosphor Sr 5 (BO 3 ) 3 Cl:Eu 2+ . In this paper, we firstly developed a novel blue-emitting phosphor Ca 2 B 5 O 9 Br:Eu 2+ for white LEDs. Undoubtedly, a technological problem in working with halo-based materials is the need to control the loss of weight of halide starting materials at high-temperature, which induced the deviation of the proposed composition of the phosphors [12] . Compared to the conventional high-temperature solid-state method, microwave synthesis has the advantages of shortening reaction time, small particle size, narrow particle size distribution and high purity. Consequently, for the first time, we adopted the direct microwave calcination route to prepare halo-based phosphor materials Ca 2 B 5 O 9 Br:Eu 2+ . The homogeneous products can be obtained in the relative low reaction temperature and short processing time. Accordingly, the structure, morphology and photoluminescence properties of Ca 2 B 5 O 9 Br:Eu 2+ phosphors via direct microwave calcination route were studied thoroughly in this paper. 2 Experimental The powder samples of Ca 2 B 5 O 9 Br: x Eu 2+ ( x = 0.005, 0.01, 0.03, 0.05, 0.1 and 0.2) were prepared using direct microwave calcination route. The starting materials used in the preparation were CaCO 3 (A.R.), CaBr 2 ·2H 2 O (A.R), H 3 BO 3 (A.R.) and Eu 2 O 3 (99.999%). With a mole ratio of CaCO 3 , CaBr 2 ·2H 2 O, H 3 BO 3 (A.R.) and Eu 2 O 3 = (1.5 − x ):0.55:5: x /2, the raw materials were thoroughly mixed by grinding in an agate mortar, and then placed in corundum crucible. A little excessive CaBr 2 (10%) is necessary for loss of weight in the process of the microwave calcination reaction, and it also can be acted as the flux. The highly pure carbon grains were used as a reducing agent in the microwave calcination process. The microwave calcination technique was dealt with in the Phoenix microwave ashing systems (CEM Microwave Technology Ltd., USA, frequency: f = 2450 MHz, power: P max = 1400 ± 50 W and temperature: T max = 1200 °C). The power of the microwave oven can be adjusted; accordingly its temperature and heating rate is under control. Based on this, the selected optimum microwave calcination condition was as follows; the mixed starting materials were heated by microwave energy from room temperature to 500 °C in 45 min, and processed at 500 °C for another 30 min to obtain the final Ca 2 B 5 O 9 Br:Eu 2+ phosphor materials. The X-ray diffraction patterns were recorded by using a SHIMADZU model XRD-6000 X-ray powder diffractometer (Cu kα radiation, 40 kV, 30 mA and a scanning speed 2.0°(2 θ ) min −1 ). The scanning electron microscope (SEM) (Model CSM950, OPTON, Germany) was employed to analyze the morphology of the typical sample. The excitation and emission spectra were recorded by using a PerkinElmer LS-55 fluorescence spectrophotometer with a photomultiplier tube operating at 400 V, and a 150 W Xe lamp was used as the excitation lamp. The temperature-dependence luminescence properties were measured on a HITACHI F-4500 spectrophotometer, which was combined with a self-made heating attachment and a computer-controlled electric furnace. 3 Results and discussions In 1973, Lloyd et al. [13] reported the crystal structure of Ca 2 B 5 O 9 Br for the first time, and they found that Ca 2 B 5 O 9 Br had an orthorhombic structure with a space group of Pnn 2 and lattice constants of a = 11.397(2) Å, b = 11.397(2) Å, c = 6.293(1) Å, and υ (cell volume) = 817.41 Å 3 . However, after that, there are only some reported works on Ca 2 B 5 O 9 Br series haloborates phosphor as a promising storage phosphor for X-ray imaging [14] . In this paper, we have prepared Ca 2 B 5 O 9 Br:Eu 2+ phosphor for white LEDs via the microwave calcination route. Fig. 1 gives the XRD patterns of 0.03Eu 2+ -doped Ca 2 B 5 O 9 Br phosphor, as-synthesized Ca 2 B 5 O 9 Br host and JCPDS Card file (No. 73-1013) of Ca 2 B 5 O 9 Br. By careful comparison among the given XRD patterns, their positions and intensities of the main peaks are nearly the same. It indicates that the crystal structure of the as-synthesized Ca 2 B 5 O 9 Br:Eu 2+ phosphor and Ca 2 B 5 O 9 Br host are in good agreement with the standard value from the JCPDS files of Ca 2 B 5 O 9 Br as reported by Lloyd. The present result means that the pure crystal structure of Ca 2 B 5 O 9 Br can be obtained successfully by the microwave calcination method. And the synthesis temperature is at least 300 °C lower than the conventional high-temperature solid-state method. Further, it also indicates that the crystal structure of Ca 2 B 5 O 9 Br has no obvious change after Eu 2+ doping. Fig. 2 shows the SEM image of as-synthesized Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor by microwave calcinations technique. SEM result shows that rod-like Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor grains with an average diameter of about 4–5 μm long and about 1 μm wide are uniformly distributed. Further, no sintering behavior found in the microwave heating may be attributed to a quite shorter heating and processing time. Especially, the special rod-like particle morphology under microwave irradiation can be ascribed to the so-called “thermal-runaway” phenomenon [15,16] . The existed “hot spots” were induced on the high curvature surface of mixed starting materials resulting from tending focusing of electromagnetic field. Rapid absorption of hot spots evolved in a thermal-runaway process could lead to surface melting, which in turn leads to the formation of many rod-like Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor grains. Fig. 3 presents the excitation [photoluminescence excitation (PLE); λ em = 452 nm] and emission (PL; λ ex = 411 nm and 343 nm) spectra of Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor. The PLE spectra have a broad band between 270 and 420 nm, and there are three excitation peaks around 276, 342 and 411 nm, which corresponds to the 4f–5d transition of Eu 2+ ions [17] . The above fine structure of the excitation spectra of Eu 2+ ions indicate that the site occupied by the Eu 2+ ions have a lower symmetry. The phosphor emits blue luminescence with a peak wavelength of 452 nm, and the full width at half maximum (FWHM) of this sample is about 32 nm, which shows a purer color than commercial BaMgAl 10 O 17 :Eu 2+ blue phosphor (FWHM = 51 nm) [18] . The calculated Stokes shift is about 2210 cm −1 . As is also shown in Fig. 3 , it gives the emission spectra of Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor under different excitation wavelength, 411 and 343 nm. It indicates that both emission spectra have no significant changes in the spectra configuration except for the emission intensity. The water resistance and heat-resistance of the selected Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor is also investigated. It is found that the phase structure and luminescence properties of Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor keep nearly invariable after it is soaked in the water for 24 h, which indicates that Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor has stable crystal structure and well water resistance. Fig. 4 shows the emission spectra of Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor at various temperatures. It can be seen that the Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor has comparatively low-temperature quenching effect and good heat-resistance. With increasing temperature up to 200 °C, the normalized emission intensity is decreased to 65.6% of the initial value. All the results may be due to the good thermal stability and chemical stability of Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor, which will be crucial for its potential application in white LEDs. Further, Fig. 5 gives the emission spectra of Ca 2 B 5 O 9 Br:Eu 2+ phosphor for various Eu 2+ concentrations upon 411 nm near UV excitation. As a summarization, Table 1 gives the measured and calculated optical properties parameters of Ca 2 B 5 O 9 Br: x Eu 2+ phosphor. As is shown by the data in Table 1 , the peak positions were obviously red shifted as the Eu 2+ content increased for the low Eu 2+ concentrations Ca 2 B 5 O 9 Br: x Eu 2+ phosphor. While in the high Eu 2+ concentrations Ca 2 B 5 O 9 Br: x Eu 2+ phosphor compositions, the peak positions kept nearly invariable. The similar variation trend was also found in the other two optical properties parameters, FWHM and Stokes shifts. But the variation of emission intensities appears just like a part of a parabola. The emission intensity increases from x = 0.005 to x = 0.03, and the strongest emission were obtained at the compositions of x = 0.03 (Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor), then it displays a decrease trend with further increase of x values. The inset of Fig. 5 shows the concentration dependence of the emission intensities of Ca 2 B 5 O 9 Br: x Eu 2+ phosphor. As mentioned above, Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor has the strongest blue emission. It is well known that the fluorescence mechanism of Eu 2+ in Ca 2 B 5 O 9 Br system is the 4f–5d allowed electric-dipole transition, the process of energy transfer should be controlled by electric multipole–multipole interaction. According to the report of Van Uitert [19] , if the energy transfer occurs among the same sorts of activators, the intensity of multipolar interaction can be determined from the change of the emission intensity from the emitting level which has the multipolar interaction. The emission intensity ( I ) per activator ion follows Eq. (1) : (1) I x = K [ 1 + β ( x ) θ / 3 ] − 1 where I / x is the emission intensity ( I ) per activator concentration( x ), K and β are constants for each interaction for a given host crystal, and θ is an indication of electric multipolar character; θ = 6, 8 and 10 for dipole–dipole (d–d), dipole–quadrupole (d–q), and quadrupole–quadrupole (q–q) interactions, respectively [19–20] . To get a correct θ value for the two emission centers, the dependence of log( I / x ) on log( x ) is plotted, and it yield a straight line with a slope equal to − θ /3. The fitting result for Eu 2+ emission centers, which is corresponding to the high Eu 2+ concentrations Ca 2 B 5 O 9 Br: x Eu 2+ phosphor compositions, is shown in Fig. 6 . The value of θ can be calculated as 6.63, which is approximately equal to 6. Since the value of θ equals to 6, it means that the quenching is dipole–dipole (d–d) interactions in the Ca 2 B 5 O 9 Br: x Eu 2+ phosphor compositions. 4 Conclusions In conclusion, novel blue-emitting Ca 2 B 5 O 9 Br:Eu 2+ phosphor powders were synthesized via the microwave calcination route. The pure Ca 2 B 5 O 9 Br phase structure was successfully obtained by microwave calcination route. The optimum process was as follows, the samples were heated from room temperature to 500 °C in 45 min, and processed at 500 °C for another 30 min. Scanning electron microscopy (SEM) image showed that the phosphor grains possessed a rod-like morphology phase. Investigation on concentration-dependent emission spectra indicated that Ca 2 B 5 O 9 Br:0.03Eu 2+ phosphor exhibited the strongest blue luminescence with a peak wavelength of 452 nm, FWHM of about 32 nm, Stokes shift of 2210 cm −1 , and the concentration quenching for the two Eu-site emission centers was caused by dipole–dipole interactions. The above obtained results indicated that this novel phosphor was promising as the blue component of light-conversion phosphors for white LEDs. Acknowledgements This present work was supported by the National Natural Science Foundations of China (Grant No. 20876002 ), the Beijing Natural Science Foundation (Grant No. 2082009 , Nos. 2091002 ), and the College Student Research Innovation Program of China University of Geosciences, Beijing . References [1] S. Nakamura M. Senoh T. Mukai Appl. Phys. Lett. 62 1993 2390 [2] H.S. Jang W.B. Im D.C. Lee D.Y. Jeon S.S. Kim J. Lumin. 126 2007 371 [3] J.K. Park M.A. Lim C.H. Kim H.D. Park J.T. Park S.Y. Choi Appl. Phys. Lett. 82 2003 683 [4] W.B. Im Y. Kim N.N. Fellows H. Masui G.A. Hirata S.P. DenBaars R. Seshadri Appl. Phys. Lett. 93 2008 091905 [5] Z.C. Wu J.X. Shi J. Wang M.L. Gong Q. Su J. Solid State Chem. 179 2006 2356 [6] T.S. Chan R.S. Liu I. Baginskiy Chem. Mater. 20 2008 1215 [7] Z. Zhang J. Wang M. Zhang Q. Zhang Q. Su Appl. Phys. B 91 2008 529 [8] Z.P. Yang S.L. Wang G.W. Yang J. Tian P.L. Li X. Li Mater. Lett. 61 2007 5258 [9] Z.G. Xia Q. Li J.Y. Sun Mater. Lett. 61 2007 1885 [10] Y.S. Tang S.F. Hu W.C. Ke C.C. Lin N.C. Bagkar R.S. Liu Appl. Phys. Lett. 93 2008 131114 [11] Q.H. Zhang J. Wang R.J. Yu M. Zhang Q. Su Electrochem. Solid-state Lett. 11 2008 H335 [12] J. Liu H.Z. Lian C.S. Shi J.Y. Sun J. Electrochem. Soc. 152 2005 G880 [13] D.J. Lloyd A. Levasseur C. Fouassier J. Solid State Chem. 6 1973 179 [14] A. Meijerink G. Blasse J. Lumin. 43 1989 283 [15] W.H. Sutton Bull Am. Ceram. Soc. 68 1989 376 [16] K.T. Kuo S.P. Lee S.Y. Chen B.M. Cheng H.C. Lu C.C. Ting J. Phys. Chem. Solids 69 2008 362 [17] A. Meijerink G. Blasse J. Lumin. 47 1990 1 [18] Q.H. Zeng H. Tanno K. Egoshi N. Tanamachi S.X. Zhang Appl. Phys. Lett. 88 2006 051906 [19] L.G. Van Uitert J. Electrochem. Soc. 114 1967 1048 [20] L. Ozawa P.M. Jaffe J. Electrochem. Soc. 118 1971 1678",
        "keywords": [
            "Optical materials",
            "Optical properties"
        ],
        "authors": [
            {
                "name": "Zhiguo Xia",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Environmental Engineering, Beijing Technology and Business University, Beijing 100037, China"
            },
            {
                "name": "Jiayue Sun",
                "org": ""
            },
            {
                "name": "Daimei Chen",
                "org": "School of Materials Sciences and Technology, China University of Geosciences, Beijing 100083, China"
            },
            {
                "name": "Xuefeng Wang",
                "org": "School of Materials Sciences and Technology, China University of Geosciences, Beijing 100083, China"
            }
        ],
        "venue": "Materials Chemistry and Physics",
        "year": 2010
    },
    "SpLyHote": {
        "id": "SpLyHote",
        "title": "Study on luminescence properties of Eu2+ in (Sr, Ca)4Si3O8 Cl4 host lattice",
        "abstract": "Alkali earth chlorosilicate of the type Sr4-xCaxSi3O8 Cl4 was synthesized through the high temperature solid state method. According to the Van Uitert experimental equation, luminescence properties and crystal-lattice environment of Eu2+ in Sr4-x. CaxSi3O8 Cl4 crystal were discussed. The possibilities of two Eu2+ emission centers, viz. blue and greenish-yellow centers, were found and their corresponding relationships with spectra were also discussed. When the doping amount of calcium(x) varied between 0 and 0.5, Ca2+ ions were embedded in the host lattice of Sr4Si3O8 Cl4, and the luminescence of blue center, which was ascribed to the emission of Eu2+ that substituted the octa-coordination Sr2+ sites, dominated and showed blue-green luminescence. Sr4-xCaxSi3O8 Cl4:yEu2+ exhibited greenish-yellow luminescence when the range of x was between 0.5 and 2. This was due to the fact that the Eu2+ emission originated from the formation of an impurity-trapped exciton state. Greenish-yellow emission center was located in the impurity-trapped exciton state which was the lowest excited state of this system, and the Eu2+ emission was at long wavelengths, and a large Stokes shift was observed.",
        "keywords": [
            "Chlorosilicate",
            "Host lattice",
            "Impurity-trapped exciton",
            "Luminescence",
            "Spectra"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",
        "year": 2005
    },
    "f35lamGy": {
        "id": "f35lamGy",
        "title": "Controllable multicolor upconversion luminescence of lanthanide doped NaGdF4 nanocrystals through single laser excitation at 980 nm.",
        "abstract": "Room temperature multicolor Upconversion (UC) luminescence in Yb3+, Tm3+, Er3+ ions doped NaGdF4 nanocrystals have been successfully synthesized by a hydrothermal method. As-prepared nanocrystals are highly crystalline and well-dispersed in cyclohexane to form stable and clear colloidal solutions, which demonstrates strong emission properties with a single laser excitation at 980 nm. The multicolor light consists of blue, green, and red UC radiations that correspond to transitions 1G4 --> 3H6 of Tm3+, 2H(11/2)/4S(3/2) --> 4I(15/2), and 4F(9/2) --> 4I(15/2) of Er3+ ions, respectively. The UC mechanisms were proposed based on spectral, kinetic, and pump power dependence analyses.",
        "keywords": [
            "lanthanide ions",
            "nagdf 4 nanocrystals",
            "upconversion luminescence"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jianbo Xia",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of nanoscience and nanotechnology",
        "year": 2011
    },
    "XN8IoxTA": {
        "id": "XN8IoxTA",
        "title": "Quantum cutting downconversion in Tb3+,Yb3+ codoped Sr3AlO4F phosphor",
        "abstract": "A near Infrared (NIR) quantum cutting (QC) Sr3AlO4F:Tb3+,Yb3+ phosphor was synthesized by the conventional high temperature solid-state reaction. The luminescence spectra both in visible (VIS) and NIR regions and decay lifetime curves of Tb3+ have been measured to prove energy transfer (ET) from Tb3+ to Yb3+. Quantum efficiency (QE) related to Yb3+ concentration was calculated and the highest QE was found to be 135% hen Yb3+ doped concentration at 20%. The present Tb3+ and Yb3+ co-doped Sr3AlO4F phosphor may be a promising candidate to modify the spectral of the solar light.",
        "keywords": [
            "solar cell",
            "quantum cutting",
            "cooperation energy transition"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "YiNing Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "ADVANCED MATERIALS AND ENGINEERING MATERIALS II",
        "year": 2013
    },
    "6uHjsAmE": {
        "id": "6uHjsAmE",
        "title": "Yellow-orange upconversion luminescence in NaYF 4:Er 3+, Yb 3+ phosphor synthesized by microwave combustion method",
        "abstract": "Erbium and ytterbium co-doped sodium yttrium fluoride (NaYF4:Er3+,Yb3+) was synthesized by combusting in home microwave oven directly. The structure and morphology of the sample was characterized by the X-ray diffraction (XRD) and scanning electron microscopy (SEM), and its upconversion luminescence properties were investigated in detail. Under 980nm semiconductor laser excitation, the color of upconversion luminescence of NaYF4:Er3+,Yb3+ was green and red, and its upconversion spectrum exhibited distinct emission peaks at 522, 543 and 652 nm, the emission appears yellow-orange to the naked eye. The law of luminescence intensity versus pump power proved that the intense green emission at 522 and 543 nm were from Er3+ (H-2(11/2) -> I-4(15/2) and S-4(3/2) -> I-4(15/2)), and the weaker red emission at 652 nm was from Er3+ (F-4(9/2) -> I-4(15/2)), which belong to the two photon process.",
        "keywords": [
            "Microwave Combustion",
            "Upconversion",
            "Rare earth ions",
            "NaYF4"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Chun Cao",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "MANUFACTURING SCIENCE AND TECHNOLOGY, PTS 1-3",
        "year": 2011
    },
    "pw2F7rsZ": {
        "id": "pw2F7rsZ",
        "title": "Study on the Rheological Parameters and Printability of Offset Printing Ink",
        "abstract": "Through testing the rheological parameters of three brands of commodity offset printing ink,including the viscosity,thixotropy and viscoelasticity,etc.,the mathematical model for relation between viscosity and shear rate of commodity offset ink was established by the mathematical method of fractional step nonlinear regression,and curve fitting was performed.The analysis shows that the mathematical model established for offset printing ink conforms to rheological features of a typical dispersion system,and the viscosity curve of model fits well with the test result of experiment.Through further analysis of characteristic parameters of offset printing ink and printability,the common properties of offset printing ink is finally obtained.",
        "keywords": [
            "printability",
            "offset printing ink",
            "rheological parameters"
        ],
        "authors": [
            {
                "name": "YANG Yin",
                "org": "Beijing Institute of Graphic Communication,Beijing ,China"
            },
            {
                "name": "XU Wen-cai",
                "org": "Beijing Institute of Graphic Communication,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": "Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "LUO Shi-yong",
                "org": "Beijing Institute of Graphic Communication,Beijing ,China"
            }
        ],
        "venue": "Packaging Engineering",
        "year": 2010
    },
    "RDiaxPWO": {
        "id": "RDiaxPWO",
        "title": "Synthesis and spectrum properties of dicondensed spiropyran",
        "abstract": "A compound of 4-(2-Methylene-1,3,3-trimethylindoline-2′-yl)-6,8-dibromo-1′,3′,3′trimethylspiro[3,4-dihydro-2H-1-benzopyran-2,2′-indoline] obtained from reaction of excess Fischer base with 3,5-dibromosalicylaldehyde.The structure of the compound was characterized by 1H-NMR,IR,elemental analysis and melting point.By means of UV-Vis and fluorescence spectrometers,the absorption and emission spectra of the title compound were studied and its photochromic properties were researched.The results showed that the title compound more than the corresponding spiropyran one indoline ring system and had a melting point of 50℃ improved.It's general significant shifts in the λmax=555nm of the absorption spectra of the open form and emission fluorescene properties were observed at 433nm.",
        "keywords": [
            "dicondensed spiropyran",
            "synthesis",
            "spectrum property"
        ],
        "authors": [
            {
                "name": "Sun Jiayue",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Ji Yidong",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            },
            {
                "name": "Zhou Wei",
                "org": "College of Chemical and Environmental Engineering,Beijing Technology and Business University,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2009
    },
    "cNU9vdsG": {
        "id": "cNU9vdsG",
        "title": "Upconversion Luminescence Properties of ZBLAN∶Nd~(3+),Tm~(3+),Yb~(3+)",
        "abstract": "The ZBLAN∶Nd3+,Tm3+,Yb3+ upconversion materials were prepared by high-temperature solid method.The concentrations of Tm3+ and Yb3+ were 0.01% and 0.3% respectively.The concentration of Nd3+ changed in the range from 0.1% to 2%.The absorption spectrum of ZBLAN∶Nd3+,Tm3+,Yb3+ in all samples from 300 to 1 000 nm was measured at room temperature.The upconversion emission was observed when excited by 798 nm infrared light.The material samples emitted relatively strong multi-band(the red,blue and green color) visible light.Based on the experiment,the multi-band visible spectral lines were analyzed,and the energy level transition mechanism was given.The blue light results from the transition of 1G4→3H6 of Tm3+,the green light is from the transition of 2H7/2→4I9/2 of Nd3+,and the red light originates from the transition of 2H11/2→4I9/2 of Nd3+.The results show that the upconversion mechanism includes excited state absorption,energy transfer,cross relaxation and so on.The energy transfer processes between Nd3+,Tm3+ and Yb3+ ions both forward and backward prove to be the origin of upconversion emissions.The effect of rare earth doping concentration on the energy upconversion efficiency was analyzed,according to the different upconversion light emitting intensity from samples with different Tm3+ mol concentrations.The upconversion luminescence increased with the Nd3+ concentration and got its peak at 1.5%.",
        "keywords": [
            "Fluorescence spectrum",
            "Tm3+ and Yb3+∶ZBLAN glasses",
            "Rare earth ions",
            "Upconversion",
            "Nd3+"
        ],
        "authors": [
            {
                "name": "YANG Zhi-ping",
                "org": " School of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": " School of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "SUN Jia-yue",
                "org": " School of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": " School of Chemistry and Environmental Engineering,Beijing Technology and Business University,Beijing ,China"
            }
        ],
        "venue": "Spectroscopy and Spectral Analysis",
        "year": 2009
    },
    "9H3jLR4U": {
        "id": "9H3jLR4U",
        "title": "Research and application of photoluminescent organic rare earth complex material",
        "abstract": "In the article,it'was introduced luminant characteristics,organic complexant,co-fluorescence effect and development of the photoluminescent organic rare earth complex.It's also illustrated the practical application in analysis chemistry,biology,medicine and scientific research practice for the different types of the photoluminescent organic rare earth complex.In the end,this new functional material will have a wonderful prospect.",
        "keywords": [
            "rare earth",
            "application",
            "photoluminescence",
            "organic complex",
            "co-fluorescence effect"
        ],
        "authors": [
            {
                "name": "Zhang Quanping",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            },
            {
                "name": "Du Haiyan",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            },
            {
                "name": "Sun Jiayue",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            },
            {
                "name": "Xiao Yang",
                "org": "Beijing Technology and Business University Applied Chemistry,Beijing "
            }
        ],
        "venue": "New Chemical Materials",
        "year": 2006
    },
    "NY8jDghx": {
        "id": "NY8jDghx",
        "title": "Facile room temperature synthesis of SrSO{sub 4}:RE (RE = Sm{sup 3+}, Tb{sup 3+}, Ce{sup 3+}) microrods via a precipitation method and its luminescence properties",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Guangchao Sun",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            }
        ],
        "venue": "Materials Research Bulletin",
        "year": 2013
    },
    "TIXO8XDz": {
        "id": "TIXO8XDz",
        "title": "Luminescence properties and energy transfer investigations of Sr 2B 2O 5:Ce 3+,Tb 3+ phosphors",
        "abstract": "Ce 3+ and Tb 3+ co-doped Sr 2B 2O 5 phosphors were synthesized by the solid-state method. X-ray diffraction (XRD) was used to characterize the phase structure. The luminescent properties of Ce 3+ and Tb 3+ co-doped Sr 2B 2O 5 phosphors were investigated by using the photoluminescence emission, excitation spectra and reflectance spectra, respectively. The excitation spectra indicate that this phosphor can be effectively excited by near ultraviolet (n-UV) light of 317 nm. Under the excitation of 317 nm, Sr 2B 2O 5:Ce 3+,Tb 3+ phosphors exhibited blue emission corresponding to the f-d transition of Ce 3+ ions and green emission bands corresponding to the f-f transition of Tb 3+ ions, respectively. The Reflectance spectra of the Sr 2B 2O 5:Ce 3+,Tb 3+ phosphors are noted that combine with Ce 3+ and Tb 3+ ion absorptions. Effective energy transfer occurred from Ce 3+ to Tb 3+ in Sr 2B 2O 5 host due to the observed spectra overlap between the emission spectrum of Ce 3+ ion and the excitation spectrum of Tb 3+ ion. The energy transfer efficiency from Ce 3+ ion to Tb 3+ ion was also calculated to be 90%. The phosphor Sr 2B 2O 5:Ce 3+,Tb 3+ could be considered as one of double emission phosphor for n-UV excited white light emitting diodes. © 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.",
        "keywords": [
            "Energy transfer",
            "Luminescence",
            "Phosphor",
            "White LEDs"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jinli Lai",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2012
    },
    "0bcU3Z3p": {
        "id": "0bcU3Z3p",
        "title": "Upconversion luminescent properties of YVO 4:Tm 3+,Ho 3+,Yb 3+",
        "abstract": "YVO4 co-doped with Tm3+/Ho3+/Yb3+ were synthesized by the high temperature solid state method and the optical properties of phosphors were characterized. Intense visible emissions centered at around 475, 541 and 649 nm, originated from the transitions of Tm3+:(1)G(4)-> H-3(6), Ho3+:S-5(2)/F-5(4)-> I-5(8), Tm3+:(1)G(4)-> F-3(4) and Ho3+:F-5(5)-> I-5(8), respectively, have been observed in samples upon excitation with a 980 nm laser diode, and the involved mechanisms have been explained.",
        "keywords": [
            "Upconversion",
            "Luminescent properties",
            "Energy transfer"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Jicheng Zhu",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Junhui Zeng",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China Univ Geosci, Sch Mat Sci, Beijing 100083, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technol & Business Univ, Sch Sci, Beijing 100048, Peoples R China"
            }
        ],
        "venue": "PROGRESS IN NEW MATERIALS AND MECHANICS RESEARCH",
        "year": 2012
    },
    "AqhM9NEA": {
        "id": "AqhM9NEA",
        "title": "Luminescent properties of LiBaPO 4:RE (RE Eu 2, Tb 3, Sm 3) phosphors for white light-emitting diodes",
        "abstract": "Multicolor emitting phosphors LiBaPO 4:RE (RE Eu 2+, Tb 3+, Sm 3+) reported as interesting down-conversion luminescent materials in white light-emitting diodes (w-LEDs) have been prepared by a conventional solid-state reaction. The excitation and emission spectra indicate that these phosphors can be effectively excited by the near-UV light, and emit blue, green, and red light, respectively. The photoluminescence properties, decay times, and Commission Internationale de I'Eclairage (CIE) chromaticity indexes are determined for various concentrations of the activators Eu 2+, Tb 3+, and Sm 3+ in LiBaPO 4 host. Furthermore, the temperature-dependent luminescence of these phosphors was investigated. The emission intensities of Tb 3+- and Sm 3+-doped LiBaPO 4 increased unexpectedly with increasing temperature. This interesting phenomenon is proposed to be the result of two ground states in the configurational coordination diagram. The present investigation suggests that LiBaPO 4:RE (RE Eu 2+, Tb 3+, Sm 3+) were potential candidates for application in w-LEDs. © 2012 American Institute of Physics.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jiayue Sun",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Xiangyan Zhang",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            },
            {
                "name": "Zhiguo Xia",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Haiyan Du",
                "org": "Beijing Technology & Business University(Beijing Technology and Business University,School of Information Engineering, Beijing Technology and Business University),Beijing,China"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2012
    },
    "B6aQgix7": {
        "id": "B6aQgix7",
        "title": "Improved moisture resistance of SrSO4:Sm3+ phosphors coated with SiO2",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiayue sun",
                "org": ""
            },
            {
                "name": "randi sun",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2012
    },
    "oxHo5heV": {
        "id": "oxHo5heV",
        "title": "Vapor-liquid heat regeneration cycle performance of R22 and alternative refrigerants",
        "abstract": "The vapor-liquid heat regeneration cycles of R22 and seven alternative refrigerants were studied.The results showed that the vapor-liquid heat regeneration was always beneficial to the refrigeration performance of R134a,R290,R407C and R507.Heat regeneration had negative influence on cycle performance of R717 in all calculated conditions.At a higher condensation temperaturet,he effect of vapor-liquid heat regeneration for R22 and R410A changed from negative to positive.In addition,performance improvement by heat regenerator was discussed for seven alternative refrigerants of R22.This work provides the database for choosing proper alternative refrigerant of R22 in different situations.",
        "keywords": [
            "refrigeration cycle",
            "alternative refrigerants",
            "heat regeneration",
            "air condition",
            "refrigerating capacity"
        ],
        "authors": [
            {
                "name": "DU Haiyan",
                "org": "School of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "GUO Hang",
                "org": "School of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "LIU Jia",
                "org": "School of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "ZHAO Peng",
                "org": "School of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "LI Heng",
                "org": "School of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            }
        ],
        "venue": "Chemical Industry and Engineering Progress",
        "year": 2007
    },
    "ao2KHsWv": {
        "id": "ao2KHsWv",
        "title": "Slab-Column Base isolated Structure's Tentative Plan and Simplified Calculation in the Earthquake",
        "abstract": "Slab-column base isolated structure is a new type of structures;it combines the Slab-column structure and the base isolated structure.It has many advantages,but the actual application is rare.This paper first discusses the characteristics of this structure,and then discusses a simplified calculation method that applies to the structure in the earthquake.This method is based on the equivalent lateral force method.The method is a simplified design method;it can provide certain references for the calculation of the actual design.",
        "keywords": [
            "base isolated",
            "simplified design method",
            "slab-column"
        ],
        "authors": [
            {
                "name": "LI Jian-cheng",
                "org": "College of architecture and civil engineering,Beijing university of Technology,Beijing ,China"
            },
            {
                "name": "ZHAO Yu-cheng",
                "org": "College of architecture and civil engineering,Beijing university of Technology,Beijing ,China"
            },
            {
                "name": "DU Hai-yan",
                "org": "College of architecture and civil engineering,Beijing university of Technology,Beijing ,China"
            }
        ],
        "venue": "Construction & Design for Project",
        "year": 2007
    },
    "AVYQCA7v": {
        "id": "AVYQCA7v",
        "title": "Experimental Study on Seismic Performance of Buckling-restrained Brace Made of Q235 Hot-rolled Steel in China",
        "abstract": "With hot-rolled Q235 steel material produced in China,some specimens of buckling-restrained brace are designed and manufactured.Mechanical properties of the material are tested.Six specimens with three steel categories,three kinds of cross section shape and two kinds of composed method are tested under statically cyclic loading.Seismic performances are studied.It is proved that Q235 steel production suits making buckling-restrained braces.The BRB with the steel are reliable with good function and excellent seismic performance.The mechanical behavior of the BRB with the steel will favor industrial standardization and normalization.",
        "keywords": [
            "hot rolled steel",
            "buckling restrained brace",
            "seismic dissipation"
        ],
        "authors": [
            {
                "name": "Gao Xiangyu",
                "org": "College of Architecture and Civil Eng.,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Du Haiyan",
                "org": "College of Architecture and Civil Eng.,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Zhang Hui",
                "org": "College of Architecture and Civil Eng.,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Liang Feng",
                "org": "College of Architecture and Civil Eng.,Beijing University of Technology,Beijing ,China"
            }
        ],
        "venue": "Building Structure",
        "year": 2008
    },
    "viBuvTkr": {
        "id": "viBuvTkr",
        "title": "Buckling Supports Structure Technology and Application Prospect",
        "abstract": "The Buckling-Restrained Brace(BRB) is superior to traditional brace because of its buckling inhabitation and good energy dissipation ability as well as ductility during earthquake.The BRB Frame(BRBF)has been comparatively widely used as a new type of energy dissipation and seismic mitigation component in USA,Japan and Chinse Taiwan,etc.It has been used little in mainland,China.The composition of the BRB is analyzed.The state of art of the current research and engineering application of the BRB and BRBF at home and abroad are outlined,and has made some suggestion.",
        "keywords": [
            "seismic mitigation",
            "buckling-restrained brace",
            "energy dissipation",
            "BRBF"
        ],
        "authors": [
            {
                "name": "DU Hai-yan",
                "org": "College of architecture and civil engineering,Beijing university of technology,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": "College of architecture and civil engineering,Beijing university of technology,Beijing ,China"
            },
            {
                "name": "GAO Xiang-yu",
                "org": "College of architecture and civil engineering,Beijing university of technology,Beijing ,China"
            }
        ],
        "venue": "Construction & Design for Project",
        "year": 2007
    },
    "OMpiJrHk": {
        "id": "OMpiJrHk",
        "title": "Study on Effective Damping Ratio of Buckling-restrained Brace with Asymmetrically Mechanical Properties",
        "abstract": "The usually existed asymmetrical mechanical properties of buckling-restrained brace is introduced and studied.A hysteric resisting force-displacement model with considering the asymmetry is developed.The calculation formulas to effective damping ratio suitable for two kinds of seismic reduction considerations,as well as displacement-based calculation formulas are studied.Some relative design conceptions to make good use of the braces are discussed and suggested.",
        "keywords": [
            "effective damping ratio",
            "seismic mitigation",
            "seismic design",
            "buckling-restrained brace",
            "energy dissipation"
        ],
        "authors": [
            {
                "name": "Gao Xiangyu",
                "org": "College of Architecture and Civil Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Li Yongmei",
                "org": "College of Architecture and Civil Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Zhang Hui",
                "org": "College of Architecture and Civil Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Du Haiyan",
                "org": "College of Architecture and Civil Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "Liang Feng",
                "org": "College of Architecture and Civil Engineering,Beijing University of Technology,Beijing ,China"
            }
        ],
        "venue": "Building Structure",
        "year": 2008
    },
    "FKxtkgNh": {
        "id": "FKxtkgNh",
        "title": "Application of heat pipes in solar water heaters",
        "abstract": "As a high-efficiency heat-exchange unit,heat pipe has wide application in solar water heater.Collector is an important part of solar water heater.The state of the art of all kinds of solar collector with heat pipes is reviewed in this paper.The feasibility of application of heat pump and air conditioning system combined with heat pipe solar water heater in the energy conservation building is discussed.Main issues,which restrain the development of heat pipes solar water heater,are discussed and analyzed.",
        "keywords": [
            "solar collectors",
            "solar water heaters",
            "energy saving in buildings",
            "heat pipes"
        ],
        "authors": [
            {
                "name": "DU Haiyan",
                "org": "College of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "GUO Hang",
                "org": "College of Environmental and Energy Engineering,Beijing University of Technology,Beijing ,China"
            }
        ],
        "venue": "Chemical Industry and Engineering Progress",
        "year": 2008
    },
    "Oj1OKJlF": {
        "id": "Oj1OKJlF",
        "title": "Application and Prospect on the Buckling-Restrained Brace in Seismic Mitigation and Reinforcement of Structure",
        "abstract": "Buckling-restrained brace (BRB), with enhanced lateral stiffness and higher earthquake energy dissipation capacity, it can be used in seismic mitigation and retrofitting of structure. Taking an engineering case as an example, this paper describes the process and merit of the BRB technology. Since this technology has been popularly applied in foreign countries, we put forward some suggestions for making good use of this technology in China.",
        "keywords": [
            "Seismic mitigation",
            "Energy dissipation",
            "Retrofit",
            "Buckling-restrained brace"
        ],
        "authors": [
            {
                "name": "Zhang Hui",
                "org": "College of Architecture and Civil Engineering, Beijing University of Technology, Beijing , China"
            },
            {
                "name": "Du Haiyan",
                "org": "College of Architecture and Civil Engineering, Beijing University of Technology, Beijing , China"
            },
            {
                "name": "Gao Xiangyu",
                "org": "College of Architecture and Civil Engineering, Beijing University of Technology, Beijing , China"
            }
        ],
        "venue": "Technology for Earthquake Disaster Prevention",
        "year": 2007
    },
    "q3jBj4kn": {
        "id": "q3jBj4kn",
        "title": "A new approach for epoxidation of fatty acids by a paired electrosynthesis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wanjie li",
                "org": ""
            },
            {
                "name": "meifeng tian",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "zhenhai liang",
                "org": ""
            }
        ],
        "venue": "Electrochemistry Communications",
        "year": 2015
    },
    "K7b15JHN": {
        "id": "K7b15JHN",
        "title": "Microwave-induced shape-memory poly(vinyl alcohol)/poly(acrylic acid) interpenetrating polymer networks chemically linked to SiC nanoparticles",
        "abstract": "Microwave (MW)-induced shape-memory poly(vinyl alcohol)/poly(acrylic acid) (PVA/PAA) interpenetrating polymer networks (SMP-IPNs) were prepared through in situ polymerization. Silicon carbide (SiC) nanoparticles were modified by 3-(methacryloyloxy) propyltrimethoxysilane (KH570). 3-(Methacryloyloxy) propyltrimethoxysilane was covalently bonded on the surface of SiC through the reaction of silanol and the methoxy groups. The polymerization of acrylic acid (AA) using N,N′-methylenebis (2-propenamide) (MBA) as cross-linker in PVA solution was initiated through the double bonds of KH-570 grafted on SiC, leading to a PAA polymer network cross-linked with MBA. The PVA molecular chains run through the PAA cross-linking network and form an IPN structure. Therefore, SiC as a strong MW absorbing material could be chemically cross-linked into polymer matrix. The effect of composition on the properties of SMP-IPN was studied using dynamic mechanical analysis, dielectric properties and shape memory effect (SME) test. The results showed that the introduction of SiC in IPNs not only provided samples with excellent MW-induced shape memory effect (SME), but also caused a higher equilibrium temperature under MW irradiation. Moreover, both SiC content and applied MW power affected the shape recovery properties of PVA/PAA interpenetrating composites. MW-induced SMPs offered great advantages such as fast recovery, high recovery rate, and remote actuation. This study provides the potential applications of the fast and environmentally friendly SMPs used as MW-responsive sensors, implantable devices, etc.",
        "keywords": [
            "Shape-memory polymer",
            "Microwave-induced interpenetrating polymer networks",
            "Poly(vinyl alcohol)",
            "Poly(acrylic acid)"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan,China"
            },
            {
                "name": "Zhe Ren",
                "org": "College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan,China"
            },
            {
                "name": "Yuyu Xu",
                "org": "College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan,China"
            }
        ],
        "venue": "Iranian Polymer Journal",
        "year": 2018
    },
    "htfmTzqu": {
        "id": "htfmTzqu",
        "title": "Theoretical calculation and experimental study on the conductivity and stability of Bi-doped SnO 2 electrode",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wenyan dong",
                "org": ""
            },
            {
                "name": "xuejia xie",
                "org": ""
            },
            {
                "name": "jinqian jia",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "liping zhong",
                "org": ""
            },
            {
                "name": "zhenhai liang",
                "org": ""
            },
            {
                "name": "peide han",
                "org": ""
            }
        ],
        "venue": "Electrochimica Acta",
        "year": 2014
    },
    "MoFLjkO8": {
        "id": "MoFLjkO8",
        "title": "New binary Mn and Cr mixed oxide electrocatalysts for the oxygen evolution reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiuli song",
                "org": ""
            },
            {
                "name": "tailai yang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "wenyan dong",
                "org": ""
            },
            {
                "name": "zhenhai liang",
                "org": ""
            }
        ],
        "venue": "Journal of Electroanalytical Chemistry",
        "year": 2016
    },
    "H0Rv7VDS": {
        "id": "H0Rv7VDS",
        "title": "PEDOT solid‐state polymer supercapacitor assembled with a KI‐doped gel polymer electrolyte",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Fangji Gan",
                "org": "School of Mechanical Engineering Sichuan University Chengdu 610065 China"
            },
            {
                "name": "Yuyu Xu",
                "org": "College of Chemistry and Chemical Engineering Taiyuan University of Technology, Yingze West Street 79 Taiyuan 030024 China"
            },
            {
                "name": "Huimin Yang",
                "org": "College of Chemistry and Chemical Engineering Taiyuan University of Technology, Yingze West Street 79 Taiyuan 030024 China"
            },
            {
                "name": "Zhe Ren",
                "org": "College of Chemistry and Chemical Engineering Taiyuan University of Technology, Yingze West Street 79 Taiyuan 030024 China"
            },
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Chemical Engineering Taiyuan University of Technology, Yingze West Street 79 Taiyuan 030024 China"
            }
        ],
        "venue": "",
        "year": 2019
    },
    "96irtPBO": {
        "id": "96irtPBO",
        "title": "Poly(3,4-ethylenedioxythiophene) Based Solid-State Polymer Supercapacitor with Ionic Liquid Gel Polymer Electrolyte.",
        "abstract": "In this work, solid-state polymer supercapacitor (SSC) was assembled using poly(3,4-ethylenedioxythiophene/carbon paper (PEDOT/CP) as an electrode and ionic liquid (1-butyl-3-methylimidazole tetrafluoroborate)/polyvinyl alcohol/sulfuric acid (IL/PVA/HSO) as a gel polymer electrolyte (GPE). The GPE was treated through freezing-thawing (F/T) cycles to improve the electrochemical properties of PEDOT SSC. Cyclic voltammetry (CV), galvanostatic charge-discharge measurements (GCD) and electrochemical impedance spectroscopy (EIS) techniques and conductivity were carried out to study the electrochemical performance. The results showed that the SSC based on ionic liquid GPE (SSC-IL/PVA/HSO) has a higher specific capacitance (with the value of 86.81 F/g at 1 mA/cm) than the SSC-PVA/HSO.The number of F/T cycles has a great effect on the electrochemical performance of the device. The energy density of the SSC treated with 3 F/T cycles was significantly improved, reaching 176.90 Wh/kg. Compared with the traditional electrolytes, IL GPE has the advantages of high ionic conductivity, less volatility, non-flammability and wider potential window. Moreover, the IL GPE has excellent elastic recovery and self-healing performance, leading to its great potential applications in flexible or smart energy storage equipment.",
        "keywords": [
            "1-butyl-3-methylimidazolium tetrafluoroborate",
            "gel polymer electrolyte",
            "poly(3,4-ethylenedioxythiophene)",
            "solid state supercapacitor"
        ],
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Yingze West Street 79, Taiyuan 030024, China."
            },
            {
                "name": "Zemin Wu",
                "org": "College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Yingze West Street 79, Taiyuan 030024, China."
            },
            {
                "name": "Yuyu Xu",
                "org": "College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Yingze West Street 79, Taiyuan 030024, China."
            },
            {
                "name": "Shaoze Liu",
                "org": "College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Yingze West Street 79, Taiyuan 030024, China."
            },
            {
                "name": "Huimin Yang",
                "org": "College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Yingze West Street 79, Taiyuan 030024, China."
            }
        ],
        "venue": "Polymers",
        "year": 2020
    },
    "VqOFNo9F": {
        "id": "VqOFNo9F",
        "title": "Microwave-Induced Poly(ionic liquid)/Poly(vinyl alcohol) Shape Memory Composites",
        "abstract": "Recently, different stimuli triggered shape memory polymer composites (SMPC) have received much research interest. However, most shape memory effects (SME) in polymer composites are mainly caused by introducing different functional inorganic fillers into polymer matrix. In the present work, the special structure of poly(ionic liquids), the heating effect of microwaves (MW), and the mechanism of SMPs are combined to design MW induced SMPC completely based on polymers, poly(ionic liquid)/poly(vinyl alcohol) (PIL/PVA) polymer networks. PILs contain anion cation pairs, which have strong MW absorption capability due to their dielectric properties. Polymer composites absorb MW energy under irradiation and generate MW heating, which could provide the required energy for shape recovery. The functional ionic liquid monomer (MIL) styrene imidazole ([VBBI][BF4]) is synthesized and polymerized. Then, PIL is mixed into PVA solution, which is crosslinked with glutaraldehyde to form P[VBBI][BF4]/PVA polymer networks. 1H NMR is used to characterize the structure of the synthesized styrene imidazole ILM and PIL. A bending test is applied to quantitatively characterize SMEs, which are affected by the PIL content in the composites and the applied MW power output. The present work combines the advantages of microwaves with PILs, opening up an efficient and environmentally friendly field for SMPs.",
        "keywords": "",
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "Taiyuan University of Technology College of Chemistry and Chemical Engineering Taiyuan China"
            },
            {
                "name": "Xiaoxiao Liu",
                "org": "Taiyuan University of Technology College of Chemistry and Chemical Engineering Taiyuan China"
            },
            {
                "name": "Yulong Yu",
                "org": "University of Twente Materials Science and Technology of Polymers Enschede AE The Netherlands"
            },
            {
                "name": "Yuyu Xu",
                "org": "Taiyuan University of Technology College of Chemistry and Chemical Engineering Taiyuan China"
            },
            {
                "name": "Yonghong Wang",
                "org": "Taiyuan University of Technology College of Chemistry and Chemical Engineering Taiyuan China"
            },
            {
                "name": "Zhenhai Liang",
                "org": "Taiyuan University of Technology College of Chemistry and Chemical Engineering Taiyuan China"
            }
        ],
        "venue": "Macromolecular Chemistry and Physics",
        "year": 2016
    },
    "BsA56vx0": {
        "id": "BsA56vx0",
        "title": "Capacitance characteristic of PEDOT electrodeposited on different substrates",
        "abstract": "Poly(3,4-ethylenedioxythiophene) (PEDOT) has been electrochemically deposited on carbon paper (CP), stainless steel mesh (SSM), stainless steel (SS), and indium tin oxide (ITO) by unipolar-pulsed method. The surface morphology, micro-structure, and electrochemical capacitance for PEDOT/substrates were characterized by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and electrochemical techniques. The electrochemical capacity measurements of the PEDOT/CP electrode in 0.5 M H2SO4 shows high mass-specific capacitance of 126.24 F/g at a 1 mA/cm2, which is consistent with the specific capacitance of 126.75 F/g at 5 mV/s. Compared with PEDOT/SSM, PEDOT/SS, and PEDOT/ITO, PEDOT/CP electrode shows better capacitive performance, which presents good rate performance of 76.78% at 5 mA/cm2 and charge-discharge stability with the capacitance retention rate of 80.57% for 5000 cycles. SEM result shows PEDOT maintained the spindle-like structure along with the threads of each carbon fiber, which are densely packed and randomly oriented forming the porous structure.",
        "keywords": [
            "Unipolar pulse method",
            " Poly(3",
            "4-ethylenedioxythiophene)/substrates",
            " Supercapacitor",
            " Electrochemical performance"
        ],
        "authors": [
            {
                "name": "Hai Yan Du",
                "org": "Taiyuan University of Technology"
            },
            {
                "name": "Xiao Xiao Liu",
                "org": "Taiyuan University of Technology"
            },
            {
                "name": "Zhe Ren",
                "org": "Taiyuan University of Technology"
            },
            {
                "name": "Pan Pan Liu",
                "org": "Taiyuan University of Technology"
            }
        ],
        "venue": "Journal of Solid State Electrochemistry",
        "year": 2018
    },
    "Zsn0oskD": {
        "id": "Zsn0oskD",
        "title": "A highly oriented poly(3,4-ethylenedioxythiophene) film: Facile synthesis and application for supercapacitor",
        "abstract": "A single crystal poly(3,4-ethylenedioxythiophene) (PEDOT) film with highly oriented arrangement has been fabricated from an aqueous solution by a novel unipolar pulse electropolymerization method. Film formation mechanism was proposed based on the in situ mass change during electropolymerization process measured by the electrochemical quartz crystal microbalance. The compositions, morphology and crystal structure of the fabricated films are characterized by Fourier transfer infrared spectroscopy, scanning electron microscopy, and X-ray diffraction, respectively. It is found that the prepared PEDOT film on carbon nanotubes (CNTs)-modified electrode with a spongy dendritic structure possesses outstanding electroactivity, high specific capacitances (239.1 F⋅g−1, including the specific capacitances of CNTs which is 21.4 F⋅g−1), and excellent cycling stability with 7.3% decay from its initial capacitance over 10,000 cycles. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43418.",
        "keywords": "",
        "authors": [
            {
                "name": "Huan Yang",
                "org": "Taiyuan University of Technology Department of Chemical Engineering Taiyuan China"
            },
            {
                "name": "Ye Liu",
                "org": "Taiyuan University of Technology Department of Chemical Engineering Taiyuan China"
            },
            {
                "name": "Zhongde Wang",
                "org": "Taiyuan University of Technology Department of Chemical Engineering Taiyuan China"
            },
            {
                "name": "Yiming Liu",
                "org": "Taiyuan University of Technology Department of Chemical Engineering Taiyuan China"
            },
            {
                "name": "Haiyan Du",
                "org": "Taiyuan University of Technology Department of Chemical Engineering Taiyuan China"
            },
            {
                "name": "Xiaogang Hao",
                "org": "Taiyuan University of Technology Department of Chemical Engineering Taiyuan China"
            }
        ],
        "venue": "Journal of Applied Polymer Science",
        "year": 2016
    },
    "iyv9dji9": {
        "id": "iyv9dji9",
        "title": "Capacitance properties of unipolar pulsed electro‐polymerized PEDOT films",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Haiyan Du",
                "org": "College of Chemistry and Chemical EngineeringTaiyuan University of TechnologyTaiyuan030024 China"
            },
            {
                "name": "Xiaoxiao Liu",
                "org": "College of Chemistry and Chemical EngineeringTaiyuan University of TechnologyTaiyuan030024 China"
            },
            {
                "name": "Zhe Ren",
                "org": "College of Chemistry and Chemical EngineeringTaiyuan University of TechnologyTaiyuan030024 China"
            },
            {
                "name": "Huimin Yang",
                "org": "College of Chemistry and Chemical EngineeringTaiyuan University of TechnologyTaiyuan030024 China"
            },
            {
                "name": "Yunlong Yu",
                "org": "National Engineering Research Center for BiomaterialsSichuan UniversityChengdu Sichuan610064 China"
            }
        ],
        "venue": "Journal of Applied Polymer Science",
        "year": 2018
    },
    "w4PvNdZt": {
        "id": "w4PvNdZt",
        "title": "Reaction Kinetics Study of All cis-Polyaniline Nanotube Film Modified Electrode for Fast Ascorbic Acid Detecting",
        "abstract": "A reaction kinetics study was performed for all cis-polyaniline nanotube (ACPN) film modified electrode for fast ascorbic acid detecting. An ACPN film modified electrode exhibited excellent electrocatalytic activity, a low detection limit and a high sensitivity to ascorbic acid (AA). It is found that AA can be electro-catalytically oxidized on an ACPN film even at a concentration less than 1 mM. A mechanism of AA electrooxidation on the ACPN film modified electrode was proposed. Furthermore, the detection sensitivity was regulated by tuning the film thickness, and the optimized fabrication conditions for the ACPN film modified electrode was obtained. Based on the reaction kinetics study, the catalytic rate constant for the best electrode was found to be 6.3x10(6) cm(3).mol(-1).s(-1). It is expected that such a sensor based on the ACPN film can be widely applied for AA detection.",
        "keywords": [
            "All cis-Polyaniline Nanotube Film",
            "Unipolar Pulse Electro-Polymerization Method",
            "Sensor",
            "Ascorbic Acid",
            "Electrooxidation"
        ],
        "authors": [
            {
                "name": "Xuli Ma",
                "org": "Department of Chemical Engineering, Taiyuan University of Technology"
            },
            {
                "name": "Xuli Ma",
                "org": "Department of Chemical Engineering, Taiyuan University of Technology"
            },
            {
                "name": "Lianxi Si",
                "org": "Department of Chemical Engineering, Taiyuan University of Technology"
            },
            {
                "name": "Xiumin Li",
                "org": "Graduate School of Science and Technology, Hirosaki University"
            },
            {
                "name": "Haiyan Du",
                "org": "Department of Chemical Engineering, Taiyuan University of Technology"
            },
            {
                "name": "Xiaogang Hao",
                "org": "Department of Chemical Engineering, Taiyuan University of Technology"
            },
            {
                "name": "Zhongde Wang",
                "org": "Department of Chemical Engineering, Taiyuan University of Technology"
            },
            {
                "name": "Abuliti Abudula",
                "org": "North Japan Research Institute for Sustainable Energy (NJRISE), Hirosaki University"
            },
            {
                "name": "Guoqing Guan",
                "org": "Graduate School of Science and Technology, Hirosaki University"
            }
        ],
        "venue": "JOURNAL OF CHEMICAL ENGINEERING OF JAPAN",
        "year": 2016
    },
    "a1nMyDs7": {
        "id": "a1nMyDs7",
        "title": "Microwave-induced shape-memory effect of silicon carbide/poly(vinyl alcohol) composite",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "zhen song",
                "org": ""
            },
            {
                "name": "jingjing wang",
                "org": ""
            },
            {
                "name": "zhenhai liang",
                "org": ""
            },
            {
                "name": "yinghua shen",
                "org": ""
            },
            {
                "name": "feng you",
                "org": ""
            }
        ],
        "venue": "Sensors and Actuators A-physical",
        "year": 2015
    },
    "Nii39BgD": {
        "id": "Nii39BgD",
        "title": "Light-induced water swelling/shrinking recovery of hydrogels based on chemically cross-linked poly (vinyl alcohol)",
        "abstract": "Photoresponsive hydrogels with high performance are of considerable interest because of their wide application. In this paper, a kind of smart poly (vinyl alcohol) (PVA) hydrogel is obtained using 4, 4′-azodibenzoic acid as cross-link agent. The hydrogels have the ability of swelling and shrinking reversibly under irradiation by ultraviolet or visible light because azobenzene groups show trans–cis isomerization under suitable light wavenumber. Under UV irradiation, azobenzene takes the cis structure which leads to volume decreases; macroscopically, shrinking can be observed. Under visible light irradiation, the volume recovers, and swelling can be observed macroscopically. Hydrogels have excellent swelling/shrinking recovery properties even after 12 cycles. The procedure achieves loop control of the transformation from light energy to mechanical energy.",
        "keywords": [
            "Poly (vinyl alcohol)",
            " Hydrogels",
            " Swelling",
            " Stimuli-sensitive",
            " High-performance polymers"
        ],
        "authors": [
            {
                "name": "junjie shi",
                "org": "china west normal university"
            },
            {
                "name": "bin wang",
                "org": "china west normal university"
            },
            {
                "name": "haiyan du",
                "org": "taiyuan university of technology"
            }
        ],
        "venue": "Colloid and Polymer Science",
        "year": 2014
    },
    "GVycbmGe": {
        "id": "GVycbmGe",
        "title": "Needle Deflection during Insertion into Soft Tissue Based on Virtual Spring Model",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "yongde zhang",
                "org": ""
            },
            {
                "name": "jingang jiang",
                "org": ""
            },
            {
                "name": "yanjiang zhao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "njkaD8MX": {
        "id": "njkaD8MX",
        "title": "Design and analysis of a novel long-distance double tendon-sheath transmission device for breast intervention robots under MRI field",
        "abstract": "Cancer represents a major threat to human health. Magnetic resonance imaging (MRI) provides superior performance to other imaging-based examination methods in the detection of tumors and offers distinct advantages in biopsy and seed implantation. However, because of the MRI environment, the material requirements for actuating devices for the medical robots used in MRI are incredibly demanding. This paper describes a novel double tendon-sheath transmission device for use in MRI applications. LeBus grooves are used in the original transmission wheels, thus enabling the system to realize long-distance and large-stroke transmission with improved accuracy. The friction model of the transmission system and the transmission characteristics model of the novel tendon-sheath structure are then established. To address the problem that tension sensors cannot be installed in large-stroke transmission systems, a three-point force measurement method is used to measure and set an appropriate preload in the novel tendon-sheath transmission system. Additionally, experiments are conducted to verify the accuracy of the theoretical model and multiple groups of tests are performed to explore the transmission characteristics. Finally, the novel tendon-sheath transmission system is compensated to improve its accuracy and the experimental results acquired after compensation show that the system satisfies the design requirements.",
        "keywords": [
            "Double tendon-sheath",
            "large-stroke transmission model",
            "LeBus grooves",
            "breast intervention robot",
            "MRI",
            "transmission device",
            "friction model"
        ],
        "authors": [
            {
                "name": "Xiaohong Jia",
                "org": "Harbin Univ Sci & Technol, Intelligent Machine Inst, Sch Mech & Power Engn, 52 Xuefu Rd, Harbin 150080, Heilongjiang, Peoples R China"
            },
            {
                "name": "Yongde Zhang",
                "org": "Harbin Univ Sci & Technol, Intelligent Machine Inst, Sch Mech & Power Engn, 52 Xuefu Rd, Harbin 150080, Heilongjiang, Peoples R China"
            },
            {
                "name": "Jingang Jiang",
                "org": "Harbin Univ Sci & Technol, Intelligent Machine Inst, Sch Mech & Power Engn, 52 Xuefu Rd, Harbin 150080, Heilongjiang, Peoples R China"
            },
            {
                "name": "Haiyan Du",
                "org": "Harbin Univ Sci & Technol, Intelligent Machine Inst, Sch Mech & Power Engn, 52 Xuefu Rd, Harbin 150080, Heilongjiang, Peoples R China"
            },
            {
                "name": "Yan Yu",
                "org": "Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA"
            }
        ],
        "venue": "ADVANCES IN MECHANICAL ENGINEERING",
        "year": 2020
    },
    "N9is0vtX": {
        "id": "N9is0vtX",
        "title": "A MRI compatible robot for breast intervention.",
        "abstract": "According to the requirements of MRI (Magnetic Resonance Imaging) surgical navigation robot, a MRI-compatible breast intervention robot is designed. Due to the available space in MRI scanner is limited, a seven DOF (Degree of Freedom) robot is designed with rectangular coordinate system. The metallic materials in nuclear magnetic environment will influence the imaging and reduce the accuracy of surgery. Resolve the MR-compatible problem by using non-magnetic stainless steels and other non-magnetic materials. Put motors out of the nuclear magnetic environment, and use a long-distance transmission way to deliver the power. Utilize MATLAB/Simulink to do working space analysis. According to the analysis results, it is testified that the robot working space can cover the whole breasts of patient. Utilize ANSYS / Workbench to do statics analysis about crucial parts of the robot. By the force simulation, the deformed patterns and stress patterns are obtained to prove that the structure of robot is reasonableness. This design lies the foundation of further study.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongde Zhang",
                "org": ""
            },
            {
                "name": "Cong Shi",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            },
            {
                "name": "Boyang Gu",
                "org": ""
            },
            {
                "name": "Yan Yu",
                "org": ""
            }
        ],
        "venue": "ROBIO",
        "year": 2015
    },
    "rmvXQMYF": {
        "id": "rmvXQMYF",
        "title": "Structure Design and Analysis of a Compact Breast Biopsy Robot under MRI Environment",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yongde zhang",
                "org": ""
            },
            {
                "name": "haiyan du",
                "org": ""
            },
            {
                "name": "yuqin li",
                "org": ""
            },
            {
                "name": "hongxia zhang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "exWpDHSx": {
        "id": "exWpDHSx",
        "title": "Design and Analysis of A Novel MRI-compatible Breast Biopsy RobotBehaviors.",
        "abstract": "MRI guided breast biopsy surgery is essential for the diagnosis and treatment of female breast diseases. It has great significance to research on the MRI-compatible breast biopsy robot, which can assist doctors to perform a breast biopsy surgery precisely in a narrow space of MRI scanner. In this paper, a novel MRI guided breast biopsy robot based on double shear fork mechanism is designed. The MRI compatibility and design requirements of breast biopsy robot are analyzed, and the structure design as well as space layout scheme for breast biopsy robot are proposed. The encircling breast fixation device, positioning mechanism based on double shear fork mechanism and biopsy mechanism are designed, and the virtual prototype model of breast biopsy robot is established. Besides, forward kinematics and inverse kinematics of the breast biopsy robot are analyzed, then the positioning mechanism based on double shear fork mechanism is analyzed by ANSYS/Workbench. Finally, the workspace range of the breast biopsy robot is solved by MATLAB/Simulink, which further verified the feasibility and rationality of the structure design of breast biopsy robot based on double shear fork mechanism.",
        "keywords": "",
        "authors": [
            {
                "name": "Mingyue Lu",
                "org": ""
            },
            {
                "name": "Yongde Zhang",
                "org": ""
            },
            {
                "name": "Zhaoli Hu",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            },
            {
                "name": "Suoliang Niu",
                "org": ""
            }
        ],
        "venue": "ROBIO",
        "year": 2018
    },
    "msSb8XEW": {
        "id": "msSb8XEW",
        "title": "Recent Advances on Breast Intervention Surgery Robot",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongde Zhang",
                "org": ""
            },
            {
                "name": "Xiaohong Jia",
                "org": ""
            },
            {
                "name": "Jingang Jiang",
                "org": ""
            },
            {
                "name": "Haiyan Du",
                "org": ""
            },
            {
                "name": "Yanfei Ruan",
                "org": ""
            }
        ],
        "venue": "Recent Patents on Engineering",
        "year": 2016
    },
    "BArQW5iY": {
        "id": "BArQW5iY",
        "title": "Kinematics analysis and trajectory planning for a breast intervention robot under MRI environment.",
        "abstract": "Breast cancer is one of the most common cancers and the principal cause of cancer death among women in the worldwide. Breast biopsy is a way to obtain tissue samples to determine if people suffer from breast cancer. Magnetic Resonance Imaging (MRI) can present the better performance in breast imaging than ultrasound or computed tomography, therefore a breast intervention robot for MRI guided biopsy of the breast was proposed in this paper. The structure of robot is nonmagnetic and thus the robot can operate safely within MRI scanner. Based on the study of the structure of the robot, the forward kinematics and inverse kinematics model of the robot was set up. According to the kinematics analysis and modeling, quintic polynomial interpolation methods were used in the trajectory planning of robot motion. Then the kinematics was also calculated by simulations. The simulation results showed that it can guarantee the continuous displacement, velocity and acceleration of joints. The smooth movement of the robot is vital to the physician, patient and robot itself, which helps to improve the safety of patient and the security of robot. Finally, the robot model was established and an experiment was carried out to prove that the robot runs smoothly and position accurately.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongde Zhang",
                "org": "Intelligent Machine Institute, School of Harbin University of Science and Technology, Ministry of Education, Harbin 150080, China"
            },
            {
                "name": "Mingyue Lu",
                "org": "Intelligent Machine Institute, School of Harbin University of Science and Technology, Ministry of Education, Harbin 150080, China"
            },
            {
                "name": "Haiyan Du",
                "org": "Intelligent Machine Institute, School of Harbin University of Science and Technology, Ministry of Education, Harbin 150080, China"
            }
        ],
        "venue": "CBS",
        "year": 2017
    },
    "GKat2gvu": {
        "id": "GKat2gvu",
        "title": "A Comparative Study of Shanxi Province Newly Founded Universities Physical Education in Applied Talents Training Program",
        "abstract": "The use of literature,logical analysis and expert interviews,a comparative study of Shanxi Province 6 Physical Education in Applied Talents training program,Newly physical education professionals should focus on \"local;teaching;application\" positioning,relying on holistic curriculum platform to develop the initiative adaption and services to regional economic and social development needs,scientific,and sustainable Applied Talents training program,in order to achieve the purpose of applied talents.",
        "keywords": [
            "physical education",
            "new institutions",
            "training program"
        ],
        "authors": [
            {
                "name": "ZHANG He-shui",
                "org": "The Physical Education Department of Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "The Physical Education Department of Yuncheng University,Yuncheng,Shanxi ,China"
            }
        ],
        "venue": "Sports Research and Education",
        "year": 2012
    },
    "Nwr0Y994": {
        "id": "Nwr0Y994",
        "title": "Study on the Current Situation and Optimization Measures of Yuncheng University Physical Education Specialty's Practice Teaching",
        "abstract": "Practice teaching is an important link in talents training scheme,and is the important measure to realise the goal of training practical talents.The physical education specialty's practice teaching of Yuncheng university shoud build a set of professional practice ability,basic practice ability and comprehensive ability of practice as a supplement to the diversified practice teaching system optimization measures based on the ministry of education files and the college level,location and the practice teaching platform.The method can better achieve target of the physical education and specialty application type talents training.",
        "keywords": [
            "Yuncheng University",
            "Optimization Measures.",
            "Physical Education Specialty",
            "Practice Teaching"
        ],
        "authors": [
            {
                "name": "ZHANG He-shui",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng ,China"
            },
            {
                "name": "BAO Li-xia",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng ,China"
            },
            {
                "name": "WANG Jian-Zhou",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng ,China"
            }
        ],
        "venue": "Journal of Yuncheng University",
        "year": 2012
    },
    "Q4pZUSTq": {
        "id": "Q4pZUSTq",
        "title": "Sustainable Developmen Study on Non Material Cultural Heritage of Hedong Sports",
        "abstract": "This study uses of literature,field survey,case analysis and expert interviews and other methods,studies the national non material cultural heritage of hedong sports.Research shows that: there are some problems in intergenerational inheritance,cultural and ecological environment and protection mechanism and market operation of HeDong sports.Aiming at the problems,analyzes the reasons and put forward the suggestions and measures for sustainable development.In order to provide protection and development theory for non material cultural heritage of hedong sports.",
        "keywords": [
            "Hedong sports",
            "non material cultural heritage",
            "sustainable development",
            "existing problems"
        ],
        "authors": [
            {
                "name": "BAO Li-xia",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "CHEN Hua-rong",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng,Shanxi ,China"
            }
        ],
        "venue": "Sports Research and Education",
        "year": 2012
    },
    "M9i70ZLh": {
        "id": "M9i70ZLh",
        "title": "A Thinking about the Optimization of Application-oriented Personnel Training Programs for the Physical Education Majors——A Case Study of Yuncheng University",
        "abstract": "In this paper,an current situation analysis of Physical Education Majors in the implementation of Yuncheng University utilized literature review,comparative law,and logic analysis,and put forward the optimization measures according the educational level and position of Yuncheng University at this stage and the \"University and College Physical Education Undergraduate Course Program\" as the basis of physical education personnel training programs in training objectives,curriculum offering,practice teaching,and quality evaluation four aspects.Based on it,we provide reference for Yuncheng university and the same kind of the Physical Education of National Academy.",
        "keywords": [
            "application-oriented cultivation program",
            "physical education",
            "optimization measures"
        ],
        "authors": [
            {
                "name": "ZHANG He-shui",
                "org": "Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "BAO Li-xia",
                "org": "Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "GUO Guo-bing",
                "org": "Yuncheng University,Yuncheng,Shanxi ,China"
            },
            {
                "name": "DUAN Li-mei",
                "org": "Yuncheng University,Yuncheng,Shanxi ,China"
            }
        ],
        "venue": "Sports Research and Education",
        "year": 2011
    },
    "zzNQsRax": {
        "id": "zzNQsRax",
        "title": "Analysis on Success of Olympic Champion Attribution Model——Based on Some Chinese 2008 Beijing Olympic Champions as an Example",
        "abstract": "This article uses qualitative research methods to explore the success of the 2008 Olympic champion attribution model.Based on the interview,video,and personal profiles,we make a deep analysis,summary and conclusion of the material 14 champions' personal material.Through the qualitative research on the information collected,we draw the attribution model of Chinese 2008 Olympic champions.That is the subjective effort,good psychological quality,target setting,home advantage and external support.",
        "keywords": [
            "Olympic champion",
            "research",
            "attribution model"
        ],
        "authors": [
            {
                "name": "CAI Rui",
                "org": " Department of Physical Education,Yuncheng University,Yuncheng ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": " Department of Physical Education,Yuncheng University,Yuncheng ,China"
            }
        ],
        "venue": "Bulletin of Sport Science & Technology",
        "year": 2013
    },
    "xotxaXSw": {
        "id": "xotxaXSw",
        "title": "A Study on the Monitoring of POMS of Elite Greco-Roman Wrestlers in the Period of Winter Heavy-load Training",
        "abstract": "The purpose of this study was to determine the effect of the period of heavy-load training on POMS Indexes of 28 elite Greco-Roman wrestlers in the period of winter training,and to monitor their exercise training.Conclusion: The nervous,rage,fatigue,depression,and TMD of POMS significantly increased after 4 weeks the heavy-load training,while the vigour significantly decreased;The vigour recovered and the others indexes no changed after 1 week adjusted.The mood stress,fatigue,psychological burn out,and mental fatigue of ATSMS significantly increased after 4 weeks the heavy-load training,while the feel good and self-efficacy significantly decreased;The feel good and self-efficacy recovered,but the others indexes no changed after 1 week adjusted.The changes show that POMS has its special laws,which has the characteristic of continuity and diffuse,we should combine the characteristic of indexes changes,while grasp their regularity and comprehensive monitoring.",
        "keywords": [
            "monitor",
            "heavy-load training",
            "Greco-Roman Wrestlers",
            "POMS"
        ],
        "authors": [
            {
                "name": "WANG Jian-zhou",
                "org": "PE Department,Yuncheng College,Yuncheng,Shanxi ,China"
            },
            {
                "name": "BAO Li-xia",
                "org": "PE Department,Yuncheng College,Yuncheng,Shanxi ,China"
            }
        ],
        "venue": "Journal of Physical Education Institute of Shanxi Normal University",
        "year": 2011
    },
    "jzgRIxU9": {
        "id": "jzgRIxU9",
        "title": "Effect of Sports Body-building Scheme Implementation on College Student's Physical Exercise Attitude",
        "abstract": "Selecting 50 college students for sports body-building scheme implementation in order to investigate its influence on college student's physical exercise attitude.The result shows that the sports body-building scheme implementation can effectively improve student's physical exercise attitude,influence their behavior of participation exercise.The college students of different gender have certain difference on physical exercise attitude,mainly displays in habit and subjective criteria.The effect of implementation of sports body-building scheme on college students with different gender has difference.",
        "keywords": [
            "attitude",
            "body-building",
            "student",
            "college",
            "sport",
            "physical exercise"
        ],
        "authors": [
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng ,Shanxi China."
            }
        ],
        "venue": "Bulletin of Sport Science & Technology",
        "year": 2012
    },
    "MZgxZXM5": {
        "id": "MZgxZXM5",
        "title": "Effect of Long-term Swimming Exercise on the Life Quality of the Middle-aged and the Aged Peop",
        "abstract": "The study uses Generic Quality of Life Inventory (GQOLI-74) to conduct a survey on the middle-aged and the aged people who joined swimming exercise.The middle-aged and the aged people of long-term swimming are compared to occasionally swimming from the mental function dimension and the social function in the study.The results show that:the long-term swimming exercise helps the middle-aged and the aged people in mental health;long-term swimming exercise is a very beneficial activity of the socialization;long-term swimming exercise let them have higher quality of life.",
        "keywords": [
            "swimming exercise middle-aged people aged people quality of life"
        ],
        "authors": [
            {
                "name": "Wang Jianzhou",
                "org": "P.E.Department of Yuncheng University,Yuncheng Shanxi "
            },
            {
                "name": "Bao Lixia",
                "org": "P.E.Department of Yuncheng University,Yuncheng Shanxi "
            }
        ],
        "venue": "Sports Forum",
        "year": 2012
    },
    "Eh6I2RW1": {
        "id": "Eh6I2RW1",
        "title": "A Study on the Monitoring of Some Biochemical Indexes of Elite Greco-Roman Wrestlers in the Period of Winter",
        "abstract": "The purpose of this study was to determine the effect of the period of heavy-load training on some biochemical Indexes of 28 elite Greco-Roman wrestlers in the period of winter training,and to monitor their exercise training.Conclusion: The serum C,BUN and CK values significantly increased,while the serum T/C ratio,T and Hb value significantly decreased;After they adjusted 1 week,the Biochemical indexes of the Wrestlers recovered in varying degrees.The changes show that biochemical indexes can be directly reflected by exercise training load.We should combine the characteristic of biochemical indexes changes,grasp their regularity and comprehensive monitoring.",
        "keywords": [
            "biochemical Index",
            "monitor",
            "heavy-load training",
            "Greco-Roman Wrestlers"
        ],
        "authors": [
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Physical Education,Yuncheng University,Yuncheng ,China"
            }
        ],
        "venue": "Journal of Yuncheng University",
        "year": 2012
    },
    "xHx4rwMg": {
        "id": "xHx4rwMg",
        "title": "Design in the Beam of Rack Based on AutoCAD Mechanical",
        "abstract": "The calculation function for moment of inertia and deflection line of Autodesk AutoCAD Mechanical is introduced. Its application in the design of storage rack is discussed with a case: calculating the moment of inertia for beam's section, and then calculating deflection line and safety factors by using its result.",
        "keywords": [
            "moment of inertia",
            "beam",
            "deflection line",
            "rack",
            "AutoCAD Mechanical"
        ],
        "authors": [
            {
                "name": "CHEN Yu-chai",
                "org": "Dept. of Management, Guangdong Vocational College of Science & Trade, Guangzhou "
            },
            {
                "name": "WANG Jian-zhou",
                "org": "General Factory of Scien-technical Enterprise, South China University of Technology, Guangzhou , China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2007
    },
    "IwqawKQo": {
        "id": "IwqawKQo",
        "title": "Research on the inefficient operation of our supply chain of books",
        "abstract": "This paper elaborates the inefficient operational problems existing in our supply chain of books,such as high costs,inventory,parallel and intersectional supply chains,slow response speed and low rate of product marketability,and analyzes the causes from various aspects,the institutional characteristics of the books industry,the organizational features of supply chain of books,the contractual relationships among all parties concerning the supply chains,risk-taking differences ect.The paper suggests that in book industry we should implement institutional reform,establish the risk-sharing within the channels,create distributor-based enterprise channel,accelerate the standardization of information and achieve sharing of information resources and so on.All these countermeasures mentioned in the paper will contribute to improve the operational inefficiency of supply chain of books.",
        "keywords": [
            "countermeasures",
            "inefficient operation",
            "supply chain of books"
        ],
        "authors": [
            {
                "name": "CHEN Yu-chai",
                "org": "Department of Management,Guangdong Vocational College of Science and Trade,Guangzhou ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "General Factory of Scientific and Technological Enterprise,South China Univ.of Tech.,Guangzhou ,China"
            }
        ],
        "venue": "Science-Technology and Management",
        "year": 2007
    },
    "1cqVqcGo": {
        "id": "1cqVqcGo",
        "title": "Improvement of the Sealing Structure of Catalyst Kneader",
        "abstract": "The style of sealing structure of catalyst kneader that lead to failure was analyzed. The style of buffer made with a calibration for the material and the labyrinth seal was presented. The style was proved to be effective by practical using.",
        "keywords": [
            "improvement",
            "sealing structure",
            "catalyst kneader"
        ],
        "authors": [
            {
                "name": "WANG Jian-zhou",
                "org": " General Factory of Scientific and Technological Enterprise, South China University of Technology, Guangzhou ; College of Mechanical Engineering, South China University of Technology, Guangzhou , China"
            }
        ],
        "venue": "Guangzhou Chemical Industry",
        "year": 2006
    },
    "OAUNop3I": {
        "id": "OAUNop3I",
        "title": "Study on the Causes of High Inventory for Nongovernmental Book Industry",
        "abstract": "High inventory, which has become a serious problem impeding the healthy development of nongovernmental book industry. This thesis aims to analyze the causes of book inventory for nongovernmental book industry and proposes advices for reducing the book inventory of nongovernmental book industry. The causes of book high inventory for nongovernmental book industry are the contradiction between market supply and demand, the commodity characteristics of books, and the distribution mode of consignment and guarantee of returning goods, the numerous varieties operated, large quantity of suppliers, backward management and the inefficient of logistics etc.",
        "keywords": [
            "nongovernmental book industry",
            "high Inventory",
            "book"
        ],
        "authors": [
            {
                "name": "WANG Jian-zhou",
                "org": " South China University of Technology, Guangzhou , China"
            },
            {
                "name": "CHEN Yu-chai",
                "org": " Guangdong Vocational College of Science and Trade, Guangzhou , China"
            }
        ],
        "venue": "Logistics Sci-Tech",
        "year": 2008
    },
    "mIHH0Gmg": {
        "id": "mIHH0Gmg",
        "title": "The Model of Mould Parameterized Design Based on AutoCAD",
        "abstract": "Geometrical graphic are modified by constraint in mould parameterized design based on AutoCAD. The constraint contains shape constraint and location constraint, the method of distinguishing is concluded, the solution of parameterized model is discussed in the paper.",
        "keywords": [
            "AutoCAD",
            "model of parameterized",
            "mould"
        ],
        "authors": [
            {
                "name": "SHEN Ling",
                "org": " Guangdong Communications Polytechnic, Guangzhou ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "General Factory of Scientific and Technological Enterprise, South China University of Technology, Guangzhou ,China"
            }
        ],
        "venue": "Journal of Guangdong Communications Polytechnic",
        "year": 2006
    },
    "agIA3eTc": {
        "id": "agIA3eTc",
        "title": "Design of the Single-Screw Extruders for Catalyst",
        "abstract": "The single-screw extruders for catalyst were designed, and their working principles,total structure,design of major components,and notices were presented.",
        "keywords": [
            "Catalyst",
            "Single-Screw Extruder",
            "Design"
        ],
        "authors": [
            {
                "name": "WANG Jianzhou",
                "org": "South China University of Technology,Guangzhou,,Guangdong,China"
            },
            {
                "name": "XIE Min",
                "org": "South China University of Technology,Guangzhou,,Guangdong,China"
            }
        ],
        "venue": "Chemical Engineering & Machinery",
        "year": 2006
    },
    "LAhBq3sq": {
        "id": "LAhBq3sq",
        "title": "Design of Kneader for Catalyst",
        "abstract": "The kneader was specialy designed for solid catalyst forming.The principle,overall structure and design of the main parts and matters were discussed.The kneader can satisfy technological requirements,increase the density and strength of the catalyst,improve the quality and solve the problems that the orignal material,harder catalyst,which was difficult to be extruded.",
        "keywords": [
            "catalyst",
            "design",
            "kneader"
        ],
        "authors": [
            {
                "name": "XIE Min",
                "org": "South China University of Technology,Guangzhou ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "South China University of Technology,Guangzhou ,China"
            }
        ],
        "venue": "Guangzhou Chemical Industry",
        "year": 2007
    },
    "DA5b1dae": {
        "id": "DA5b1dae",
        "title": "Design of Extruder for Single-Screw Extrude of Catalyst",
        "abstract": "The design of the extruder for single-screw extrude of catalyst in structure、 connecting method and cooling way was discussed: the type of bushings used the separated feed extruder to extrusion extruder, the grooves were produced inside the extruder for improving the convey efficiency, the connecting method that is easy to replace was used, extruder was surrounded by a water-jacket outside so that the catalyst was modified in a lower temperature to lengthen service life and improve extrusion rate of the extruder, also to ensure the production capacity and improvement the quality of catalyst.",
        "keywords": [
            "single-screw extrude",
            "catalyst",
            "design",
            "extruder"
        ],
        "authors": [
            {
                "name": "Wang Jianzhou",
                "org": " General Factory of Scientific and Technological Enterprise, South China University of Technology, Guangzhou  College of Mechanical Engineering, South China University of Technology, Guangzhou  School of Vehicle Mechanical Engineering, Guangdong Communications Polytechnic , China"
            },
            {
                "name": "Shen Ling",
                "org": " General Factory of Scientific and Technological Enterprise, South China University of Technology, Guangzhou  College of Mechanical Engineering, South China University of Technology, Guangzhou  School of Vehicle Mechanical Engineering, Guangdong Communications Polytechnic , China"
            }
        ],
        "venue": "Guangdong Chemical Industry",
        "year": 2006
    },
    "Qh6VQJVj": {
        "id": "Qh6VQJVj",
        "title": "The practical method of marking dimension in complex engineering-drawings with AutoCAD software",
        "abstract": "Marking dimension is one of the important contentin mechanical cartography.The popular AutoCAD is an open mutual powerful softw are,but there are many details which are not fit the directions of GB in the tol erant mode of marking dimension in the software.In order to meeting the needs of drawing,two sorts of marking dimension,which are the adjustment of style settin g and skillful edit of marking command,are introduced.Moreover,their applicable scopes are set forth systematically.The efficiency of complex engineering-drawi ngs with AutoCAD software can be improved greatly by the method.",
        "keywords": [
            "AutoCAD Mechanical-drawings Marking dimension"
        ],
        "authors": [
            {
                "name": "Shen Ling",
                "org": " School of Mechanical Engineering,South China University of Technology ,Guangzhou ,CHN; Guangdong Communications Polytechnic,Guangzhou ,CHN"
            },
            {
                "name": "Wang Jianzhou",
                "org": " School of Mechanical Engineering,South China University of Technology ,Guangzhou ,CHN"
            }
        ],
        "venue": "Modern Manufacturing Engineering",
        "year": 2005
    },
    "rX5P8goz": {
        "id": "rX5P8goz",
        "title": "Solve the technological of the least raw material usage in cutting stock problem using Excel",
        "abstract": "Aiming at the problem of the least raw material usage in cutting stock in industry production,established a mathematical model by adopting the theory of linear programming.The method to use the function of layout evaluation of Excel layout evaluation to solve the problem of it was introduced.The result of use show that the method is convenient、useful、simple and fast.It is very valuable to engineers.",
        "keywords": [
            "Cutting Stock Layout evaluation Excel"
        ],
        "authors": [
            {
                "name": "Wang Jianzhou",
                "org": " General Factory of Scientific and Technological Enterprise,South China Universityof Technology,Guangzhou ,CHN; College of Department of Mechanical Engineering,South China University of Technology,Guangzhou ,CHN"
            },
            {
                "name": "Chen Yuchai",
                "org": ""
            }
        ],
        "venue": "Modern Manufacturing Engineering",
        "year": 2006
    },
    "sJFHqD9k": {
        "id": "sJFHqD9k",
        "title": "Application of Operational Research in the Chemical Enterprise",
        "abstract": "The basic principles and working steps for handling problems of operational research were introduced in this paper.Based upon the practical examples,its application in chemical enterprises was also presented,which was mainly manifested in production arrangements and ingredient distribution in the technical optimization as well as the application of purchasing policies,conservation management,and transport management in enterprise management.The use of operational research methods,the establishment of model and calculation,limited resources being allocated rationally in production technology of chemical enterprises management,all of which would contribute a lot to inprove efficiency and obtain the best economic benefits.",
        "keywords": [
            "production craft",
            "operational research",
            "management",
            "chemical enterprise"
        ],
        "authors": [
            {
                "name": "Chen Yuchai",
                "org": "Department of Management,Guangdong Vocational College of Science and Trade,Guangzhou "
            },
            {
                "name": "Wang Jianzhou",
                "org": "General Factory of Scientific and Technological Enterprise,South China Univ.of Tech.,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Chemical Industry",
        "year": 2007
    },
    "lnIu63do": {
        "id": "lnIu63do",
        "title": "Stochastic analysis of uncertain thermal characteristic of foundation soils surrounding the crude oil pipeline in permafrost regions",
        "abstract": "Abstract   For foundation soils surrounding the crude oil pipeline in permafrost regions, the soil properties and the upper boundary conditions are stochastic because of complex geological processes and changeable atmospheric environment. The conventional finite element analysis of thermal characteristics for crude oil pipeline is always deterministic, rather than taking stochastic parameters and conditions into account. This study investigated the stochastic influence of an underground crude oil pipeline on the thermal stability of the permafrost foundation on the basis of a stochastic analysis model and the stochastic finite element method. A stochastic finite element program is compiled by Matrix Laboratory (MATLAB) software, and the random temperature fields of foundation soils surrounding a crude oil pipeline in a permafrost region are obtained and analyzed by Neumann stochastic finite element method (NSFEM). The results provide a new way to predict the thermal effects of the crude oil pipeline in permafrost regions, and it shows that the standard deviations in temperature increase with time when considering the stochastic effect of soil properties and boundary conditions, which imply that the results of conventional deterministic analysis may be far from the true value, even if in different seasons. It can improve our understanding of the random temperature field of foundation soils surrounding the crude oil pipeline and provide a theoretical basis for actual engineering design in permafrost regions.",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Xiaodong Zhao",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            }
        ],
        "venue": "Applied Thermal Engineering",
        "year": 2016
    },
    "qhqLnAbs": {
        "id": "qhqLnAbs",
        "title": "Deformation and strength behaviors of frozen clay with thermal gradient under uniaxial compression",
        "abstract": "Thermal gradient is one of the main features in artificial freezing ground and permafrost regions. The deformation and strength behavior of frozen soils with thermal gradient is of utmost importance for stabilities analysis of frozen engineering. A series of uniaxial compression tests were carried out on frozen saturated clay at various average temperatures and thermal gradients. The experimental results indicated that the uniaxial stress-strain curve for frozen clay with thermal gradient presents elastic-linear strain hardening characteristics, both the hardening modulus and uniaxial compression strength increase as the thermal gradient and average temperature decreased, but the elastic modulus varies little as the thermal gradient increased. The polygonal stress-strain constitutive equations were implemented into the FEM (Finite Element Method) and the local axial strain distribution of frozen clay with thermal gradient was studied. Two stages are observed from the curves describing the relationship between local axial strain and specimen height, i.e., increase stage and decrease stage for the slope of d. Characteristic parameters such as the demarcation height of Hd, the maximum slope of dmax are defined and analyzed. It is found that the characteristic parameters are all dependent on the thermal gradient and average temperature. The thermal gradient presents weakening effects to the local axial strain rate at middle specimen height of δεa,H=10'/δt in frozen clay with identical average temperature, and that further lead to the decrease of hardening modulus and uniaxial compression strength. © 2013 Elsevier Ltd.",
        "keywords": [
            "deformation",
            "frozen saturated clay",
            "strength",
            "thermal gradient",
            "uniaxial compression"
        ],
        "authors": [
            {
                "name": "Xiaodong ZHAO",
                "org": "China University of Mining Technology(China University of Mining and Technology,China Univ. of Mining and Technol.),Beijing,China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "China University of Mining Technology(China University of Mining and Technology,China Univ. of Mining and Technol.),Beijing,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "China University of Mining Technology(China University of Mining and Technology,China Univ. of Mining and Technol.),Beijing,China"
            }
        ],
        "venue": "Tunnelling and Underground Space Technology",
        "year": 2013
    },
    "A5brEBLs": {
        "id": "A5brEBLs",
        "title": "Stochastic analysis for the uncertain temperature field of tunnel in cold regions",
        "abstract": "Abstract   In cold regions, the temperature is important to determine the stability of tunnel construction. However, the conventional finite element methods for stability analysis are always deterministic, rather than taking stochastic parameters and conditions into account. In this paper, the boundary conditions are considered as stochastic processes and the rock properties are considered as random fields. A stochastic analysis for the uncertain temperature characteristics of tunnel is presented. The stochastic finite element formulae are obtained by Neumann stochastic finite element method (NSFEM), and the stochastic finite element program is compiled by Matrix Laboratory (MATLAB) software. Using our program, the random temperature fields of a tunnel in a cold region are obtained and analyzed. The results show that the temperature of a large quantity of frozen surrounding rock is stochastic, and it is bad for the thermal stability of actual tunnel engineering in cold regions. The distributions of mean temperature are the same and the distributions of standard deviation are similar for the two cases in this paper. The average standard deviation increases with time, which implies that the results of conventional deterministic analysis may be far from the true value. These results can improve our understanding of the random temperature field of tunnel and provide a theoretical basis for actual engineering design in cold regions.",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Xiaodong Zhao",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            }
        ],
        "venue": "Tunnelling and Underground Space Technology",
        "year": 2016
    },
    "ve0cZtXT": {
        "id": "ve0cZtXT",
        "title": "Estimation on the influence of uncertain parameters on stochastic thermal regime of embankment in permafrost regions",
        "abstract": "For embankments in permafrost regions, the soil properties and the upper boundary conditions are stochastic because of complex geological processes and changeable atmospheric environment. These stochastic parameters lead to the fact that conventional deterministic temperature field of embankment become stochastic. In order to estimate the influence of stochastic parameters on random temperature field for embankment in permafrost regions, a series of simulated tests are conducted in this study. We consider the soil properties as random fields and the upper boundary conditions as stochastic processes. Taking the variability of each stochastic parameter into account individually or concurrently, the corresponding random temperature fields are investigated by Neumann stochastic finite element method. The results show that both of the standard deviation under the embankment and the boundary increase with time when considering the stochastic effect of soil properties and boundary conditions. Stochastic boundary conditions and soil properties play a different role in random temperature field of embankment at different times. Each stochastic parameter has a different effect on random temperature field. These results can improve our understanding of the influence of stochastic parameters on random temperature field for embankment in permafrost regions.",
        "keywords": [
            "Soil Property",
            " Random Field",
            " Large Standard Deviation",
            " Stochastic Effect",
            " Permafrost Region"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Guoqing Zhou",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Jianzhou Wang",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Xiaodong Zhao",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Xing Chen",
                "org": "China University of Mining and Technology"
            }
        ],
        "venue": "Heat and Mass Transfer",
        "year": 2017
    },
    "7HnFL1Zj": {
        "id": "7HnFL1Zj",
        "title": "Assessment for the spatial variation characteristics of uncertain thermal parameters for warm frozen soil",
        "abstract": "Abstract   The uncertain thermal parameters of warm frozen soil are the key factors for computing the stochastic temperature field, and the spatial variability can lead to the randomness of thermodynamic characteristic. In this study, a series of thermal parameters tests for the warm frozen soil are carried out, and the thermal conductivity, heat capacity and thermal diffusivity for the different temperature (from −1.8 °C to 0 °C) are obtained. Then the variance function and the scale of fluctuation for the uncertain thermal parameters are estimated on the basis of the random field theory. The results shows that the variance functions for the thermal conductivity, heat capacity and thermal diffusivity decreased along with the increase of averaging distance. The scale of fluctuation for the thermal conductivity is between 0.96 m and 1.25 m under different freezing temperature condition; the scale of fluctuation for the heat capacity is between 0.88 m and 1.15 m, and the scale of fluctuation for the thermal diffusivity is between 0.75 m and 1.13 m. This study can improve our understanding of the spatial variation characteristics of uncertain thermal parameters for warm frozen soil and provide a theoretical basis and reference for the stochastic thermal analysis of frozen soil engineering.",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Xiong Jiang",
                "org": "CCCC Third Harbor Consultants Co., Ltd, Shanghai 200032, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            }
        ],
        "venue": "Applied Thermal Engineering",
        "year": 2018
    },
    "1lkHwRM8": {
        "id": "1lkHwRM8",
        "title": "On the frost heaving-induced pressure response and its dropping power-law behaviors of freezing soils under various restraints",
        "abstract": "Abstract   A one-dimensional frost heave testing system is developed in this paper to investigate the frost heaving-induced pressure (FHIP) of frost susceptible silty clay under various restraints and thermal gradients. The evolution of the frost heave, the moisture migration, and the FHIP are examined from the conducted freezing tests, as well as the effects of restrained stiffness and thermal gradient. The development of frost heave can be divided into four stages, i.e. the constant temperature stage, the rapid development stage, the transition development stage, and the stable stage. For tests with − 20 °C at the cold end of the tested samples, the ultimate heave is 5.88 mm, 4.86 mm and 4.31 mm, and the FHIP is 65.0 kPa, 71.1 kPa and 92.1 kPa, corresponding to the restrained stiffness of 11.06 kPa/mm, 14.62 kPa/mm and 21.36 kPa/mm, respectively. It can be found that the frost heave decreases gradually with the restrained stiffness, whereas the FHIP shows an increase with the retrained stiffness. The results indicate that the FHIP drops rapidly with the relaxation of restraints, while this downward trend slows down as the frost heaving ratio increases. It is found that the FHIP decreases following an exponential function with the increase of frost heaving ratio, and the FHIP shows a dropping power-law behavior with an exponent of approximately 8/5.",
        "keywords": "",
        "authors": [
            {
                "name": "Yukun Ji",
                "org": ""
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Xiaodong Zhao",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Zejin Lai",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Pinqiang Mo",
                "org": ""
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2017
    },
    "PWwPUo31": {
        "id": "PWwPUo31",
        "title": "Stochastic coupling analysis of uncertain hydro-thermal properties for embankment in cold regions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Yang Zhou",
                "org": "School of Mechanics and Civil Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Tuo Chen",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            }
        ],
        "venue": "Transportation geotechnics",
        "year": 2019
    },
    "2eoAb7U8": {
        "id": "2eoAb7U8",
        "title": "Stochastic analysis of uncertain temperature characteristics for expressway with wide subgrade in cold regions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guoqing zhou",
                "org": ""
            },
            {
                "name": "tao wang",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "xiaodong zhao",
                "org": ""
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2015
    },
    "vtv8IIqO": {
        "id": "vtv8IIqO",
        "title": "Stochastic analysis model of uncertain temperature characteristics for embankment in warm permafrost regions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tao wang",
                "org": ""
            },
            {
                "name": "guoqing zhou",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "xiaodong zhao",
                "org": ""
            },
            {
                "name": "qixiang yin",
                "org": ""
            },
            {
                "name": "lijiang xia",
                "org": ""
            },
            {
                "name": "yuyi liu",
                "org": ""
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2015
    },
    "gCFjNgoP": {
        "id": "gCFjNgoP",
        "title": "Stochastic analysis of uncertainty mechanical characteristics for surrounding rock and lining in cold region tunnels",
        "abstract": "Abstract   The mechanical characteristics of tunnels in cold regions are uncertain because of the randomness of temperature field and mechanical parameters. Conventional forecast analysis is always deterministic, rather than taking stochastic temperature and parameters into account. This paper aims to investigate the stochastic mechanical characteristics of tunnel in cold regions on the basis of a stochastic analysis model and stochastic finite element method. A series of computer codes is compiled by Matrix Laboratory (MATLAB) software, and the stochastic mechanical characteristics for a tunnel in a cold region are obtained and analyzed by Neumann stochastic finite element method (NSFEM). The results provide a new method to predict the uncertain mechanical characteristics of tunnel in cold regions, and it shows that the stochastic temperature has an effect on stochastic stress for surrounding rock, and the major principle stress and minor principle stress are changeable in different times. The frost heave of surrounding rock leads to the increase of mean stress and mean displacement for lining while the thawing process leads to the decline of mean stress and mean displacement for lining. With the passage of time, the stress standard deviation and displacement standard deviation for lining show an upward trend, which imply that the results of conventional deterministic analysis for mechanical characteristic of tunnel lining may be farther from the true value. These results can improve our understanding of the uncertainty mechanical characteristics for tunnel and provide a theoretical basis for engineering reliability analysis and design in cold regions.",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            },
            {
                "name": "Leijian Yin",
                "org": "School of Mechanics and Civil Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China"
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2018
    },
    "2KdIoGlW": {
        "id": "2KdIoGlW",
        "title": "Effects of different freezing rates on purification efficiency of sandy soil contaminated by heavy metal copper",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Shuxing Liu",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Guoqing Zhou",
                "org": ""
            },
            {
                "name": "Tuo Chen",
                "org": ""
            },
            {
                "name": "Yang Zhou",
                "org": ""
            },
            {
                "name": "Tao Wang",
                "org": ""
            },
            {
                "name": "Yanhu Mu",
                "org": ""
            },
            {
                "name": "Hengchang Liang",
                "org": ""
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2019
    },
    "qC9M6iMz": {
        "id": "qC9M6iMz",
        "title": "Large deformation tensile test of conducting sensitive composites based on rubber",
        "abstract": "Carbon fiber filled composites based on rubber were developed and measured by tensile test.The relationship of stress-strain,resistance-strain and conducting mechanism of the composites were studied.The deformation of geotetile reinforcement was test by sensor which was produced by carbon fiber filled composites based on rubber.The results confirm that the sensor is a feasible method for the large deformation of geotextile reinforcement test.",
        "keywords": [
            "Carbon fiber",
            "Conducting sensitive composites based on rubber",
            "Large deformation"
        ],
        "authors": [
            {
                "name": "LIAO Bo",
                "org": "School of Mechanics and Civil Engineering,State Key Lab for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou ,China"
            },
            {
                "name": "ZHOU Guo-qing",
                "org": "School of Mechanics and Civil Engineering,State Key Lab for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou ,China"
            },
            {
                "name": "LIANG Heng-chang",
                "org": "School of Mechanics and Civil Engineering,State Key Lab for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "School of Mechanics and Civil Engineering,State Key Lab for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou ,China"
            },
            {
                "name": "ZHAO Guang-si",
                "org": "School of Mechanics and Civil Engineering,State Key Lab for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou ,China"
            }
        ],
        "venue": "Journal of China Coal Society",
        "year": 2011
    },
    "yjxQhDQs": {
        "id": "yjxQhDQs",
        "title": "Stochastic analysis for uncertain deformation of foundations in permafrost regions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": ""
            },
            {
                "name": "Guoqing Zhou",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Xiaodong Zhao",
                "org": ""
            },
            {
                "name": "Leijian Yin",
                "org": ""
            }
        ],
        "venue": "Geomechanics and Engineering",
        "year": 2018
    },
    "ViW9WMWu": {
        "id": "ViW9WMWu",
        "title": "Laboratory investigation on tensile strength characteristics of warm frozen soils",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guoqing zhou",
                "org": ""
            },
            {
                "name": "kun hu",
                "org": ""
            },
            {
                "name": "xiaodong zhao",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "hengchang liang",
                "org": ""
            },
            {
                "name": "guilin lu",
                "org": ""
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2015
    },
    "Z7NrUmyJ": {
        "id": "Z7NrUmyJ",
        "title": "Cyclic direct shear behaviors of an artificial frozen soil-structure interface under constant normal stress and sub-zero temperature",
        "abstract": "Abstract   The soil-structure interface between structures and frozen soil ground is an important element to the structure safety in permafrost regions. This interface is usually subjected to a constant normal stress and cyclic shear loadings such as seismic, wind, and wave loadings. Hence, the cyclic direct shear behaviors of this interface have critical impacts on the safety and durability of the structure. This paper investigated the cyclic direct shear behaviors of an artificial frozen soil-structure interface under four constant normal stresses and four sub-zero temperatures by using a large-scale multi-functional direct shear apparatus. Cyclic shear stress and normal displacement were measured under normal stresses of 100, 300, 500, and 700 kPa and at sub-zero temperatures of − 2, − 6, − 10, and − 14 °C, respectively. These measurements revealed the following mechanical properties of this artificial interface: (1) The maximum shear stress is always observed in the initial stage of the first cycle. This maximum shear stress is linearly related to the normal stress. (2) Both the internal friction angle and the cohesion of this interface at the maximum shear stress decrease with the increase of sub-zero temperature. (3) The internal friction angle decreases with further cycles. This angle becomes significantly smaller in the stabilized cycles than that in the first cycle. (4) The maximum dilation measured by normal displacement is always observed in the first cycle. This dilation is decreasing with higher normal stress and at lower sub-zero temperature. However, the final normal displacement always contracts and its magnitude increases with the increase of normal stress or the decrease of sub-zero temperature. Finally, a simple damage model is proposed to describe these behaviors of this artificial interface and its performance is checked through its prediction for experimental data.",
        "keywords": "",
        "authors": [
            {
                "name": "Lianzhen Zhao",
                "org": "Department of Civil Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China"
            },
            {
                "name": "Lianzhen Zhao",
                "org": "Department of Civil Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Civil Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China"
            },
            {
                "name": "Lai-Chang Zhang",
                "org": "School of Engineering, Edith Cowan University, 270 Joondalup Drive, Joondalup, Perth, WA 6027, Australia"
            },
            {
                "name": "J.G. Wang",
                "org": "School of Mechanics and Civil Engineering, China University of Mining and Technology, Xuzhou 221116, China"
            }
        ],
        "venue": "Cold Regions Science and Technology",
        "year": 2017
    },
    "hPOiWNX8": {
        "id": "hPOiWNX8",
        "title": "Stochastic model and analysis of uncertain stresses characteristics for embankment in permafrost regions",
        "abstract": "Taking the randomness of mechanical parameters and thermal regime into account, a stochastic analysis model is established for investigating the uncertain stresses characteristics of embankment in permafrost regions. The stochastic finite element formulae are obtained by Neumann Stochastic Finite Element Method (NSFEM), and a stochastic coupling program is compiled by Matrix Laboratory (MATLAB) software. Using our program, the stochastic stresses fields of an embankment in a permafrost region are obtained and analyzed. The results provide a new way to predict the stresses characteristics of the embankment in permafrost regions, and it shows that the stochastic temperature has a different influence on the mean stresses and standard deviation, and the larger value is at a different location. The standard deviations in stresses increase with time when considering the stochastic effect of temperature and parameters, which imply that the results of conventional deterministic analysis may be far from the true value. It can improve our understanding of the stochastic stresses fields of embankments and provide a theoretical basis for engineering reliability analysis and design in permafrost regions.",
        "keywords": [
            "stochastic analysis",
            " uncertain stresses characteristic",
            " embankment in permafrost regions",
            " stochastic finite element"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Guoqing Zhou",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Jianzhou Wang",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Xiaodong Zhao",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Yuyi Liu",
                "org": "China University of Mining and Technology"
            }
        ],
        "venue": "Ksce Journal of Civil Engineering",
        "year": 2017
    },
    "dxdiz1jp": {
        "id": "dxdiz1jp",
        "title": "Stochastic analysis of uncertain thermal parameters for random thermal regime of frozen soil around a single freezing pipe",
        "abstract": "The artificial ground freezing method (AGF) is widely used in civil and mining engineering, and the thermal regime of frozen soil around the freezing pipe affects the safety of design and construction. The thermal parameters can be truly random due to heterogeneity of the soil properties, which lead to the randomness of thermal regime of frozen soil around the freezing pipe. The purpose of this paper is to study the one-dimensional (1D) random thermal regime problem on the basis of a stochastic analysis model and the Monte Carlo (MC) method. Considering the uncertain thermal parameters of frozen soil as random variables, stochastic processes and random fields, the corresponding stochastic thermal regime of frozen soil around a single freezing pipe are obtained and analyzed. Taking the variability of each stochastic parameter into account individually, the influences of each stochastic thermal parameter on stochastic thermal regime are investigated. The results show that the mean temperatures of frozen soil around the single freezing pipe with three analogy method are the same while the standard deviations are different. The distributions of standard deviation have a great difference at different radial coordinate location and the larger standard deviations are mainly at the phase change area. The computed data with random variable method and stochastic process method have a great difference from the measured data while the computed data with random field method well agree with the measured data. Each uncertain thermal parameter has a different effect on the standard deviation of frozen soil temperature around the single freezing pipe. These results can provide a theoretical basis for the design and construction of AGF.",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou,China"
            },
            {
                "name": "Guoqing Zhou",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "State Key Laboratory for Geomechanics and Deep Underground Engineering,China University of Mining and Technology,Xuzhou,China"
            },
            {
                "name": "Lei Zhou",
                "org": "School of Mechanics and Civil Engineering,China University of Mining and Technology,Xuzhou,China"
            }
        ],
        "venue": "Heat and Mass Transfer",
        "year": 2018
    },
    "7A6GXhgc": {
        "id": "7A6GXhgc",
        "title": "Influence of the hydration heat of cast-in-situ concrete on temperature field and stability of soil-pile in high-temperature permafrost regions",
        "abstract": "",
        "keywords": [
            "boundary condition",
            "solvation",
            "stability",
            "heating",
            "concrete",
            "boundary conditions",
            "numerical analysis"
        ],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": "china university of mining and technology"
            },
            {
                "name": "guoqing zhou",
                "org": "china university of mining and technology"
            },
            {
                "name": "jinsheng zhou",
                "org": "china university of mining and technology"
            },
            {
                "name": "xiaoyong bie",
                "org": ""
            },
            {
                "name": "s li",
                "org": "community college of rhode island"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "qzod6srE": {
        "id": "qzod6srE",
        "title": "Stochastic Thermal-Mechanical Characteristics of Frozen Soil Foundation for a Transmission Line Tower in Permafrost Regions",
        "abstract": "<p>The Qinghai–Tibet Power Transmission Line (QTPTL), crossing about 550 km of permafrost region, was constructed between July 2010 and October 2011. The long-term thermal-mechanical stabilities attract extensive attention because of global warming and engineering activities. Conventional calculation and prediction of the thermal-mechanical characteristics of a frozen soil foundation for the QTPTL always involve deterministic analysis. This study aimed to investigate the uncertain thermal-mechanical characteristics of a transmission tower foundation by a stochastic analysis method. Considering the effect of stochastic temperature on the stochastic deformation, a stochastic coupling computer program was compiled. The random temperature fields and random deformation fields of foundation soils for a transmission line tower in a permafrost region were calculated and predicted for the next 30 years. This work provides a novel method to analyze the stochastic thermal-mechanical characteristics of a frozen soil foundation for a transmission line tower in permafrost regions. The average standard deviations of temperature grew from 1.1 to 1.6°C on January 15, and the maximum standard deviations of temperature were grew from 3.0 to 3.5°C. The average standard deviations of vertical displacement grew from 0.46 to 0.79 cm on January 15, and the maximum standard deviations of vertical displacement grew from 1.81 to 21.2 cm. The increase of standard deviations implies that the results of conventional prediction methods for temperature and deformation may be deviate from the exact value. These results can clarify the stochastic thermal-mechanical characteristics of frozen soil foundations for the QTPTL in permafrost regions.</p>",
        "keywords": [
            "Soil properties",
            "Power transmission",
            "Foundations",
            "Frozen soils",
            "Temperature effects",
            "Stochastic processes",
            "Permafrost",
            "Thermal effects"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": "Lecturer, State Key Laboratory for Geomechanics and Deep Underground Engineering, School of Mechanics and Civil Engineering, China Univ. of Mining and Technology, Xuzhou, Jiangsu 221116, China (corresponding author)."
            },
            {
                "name": "Guoqing Zhou",
                "org": "Professor, State Key Laboratory for Geomechanics and Deep Underground Engineering, China Univ. of Mining and Technology, Xuzhou, Jiangsu 221116, China."
            },
            {
                "name": "Jianzhou Wang",
                "org": "Associate Professor, State Key Laboratory for Geomechanics and Deep Underground Engineering, China Univ. of Mining and Technology, Xuzhou, Jiangsu 221116. China."
            },
            {
                "name": "Leijian Yin",
                "org": "Graduate Student, School of Mechanics and Civil Engineering, China Univ. of Mining and Technology, Xuzhou, Jiangsu 221116, China."
            }
        ],
        "venue": "International Journal of Geomechanics",
        "year": 2018
    },
    "M3ieGwgh": {
        "id": "M3ieGwgh",
        "title": "Surgery of vitreous hemorrhage combined with sub-inner limiting membrane hemorrhage",
        "abstract": "Objective To explore clinical characteristics and treatment of vitreous hemorrhage combined with sub-inner limiting membrane(sub-ILM)hemorrhage in the cases of ocular blunt trauma and craniocerebral injury.Methods Nine cases(14 eyes)with vitreous hemorrhage combined with sub-ILM hemorrhage underwent axial vitrectomy and ILM peeling or cutting to clear off sub-ILM hemorrhage,including 3 eyes of 3 cases with ocular blunt trauma and 11 eyes of 6 cases with Terson syndrome.Results The preoperative visual acuity was to count fingers with hand movement in front of eyes,and postoperative visual acuity ranged from 0.5 to 1.0.Patients with a short course of bleeding got better vision than those with a long course,and the best visual acuity was 0.6.According to the duration of case history,the ILM in the hemorrhagic areas were cut or peeled off.The remote hemorrhage,which could not be completely removed by surgery,was absorbed during postoperative 5 to 10 days.Relatively stable vision remained during followed-up for 6 months to 3 years.Conclusions Both two situations can cause vitreous hemorrhage and sub-ILM hemorrhage.According to the form of vitreous hemorrhage,axial vitrectomy can be a choice.Cutting ILM is not the purpose,but the key point is to draw off sub-ILM hemorrhage.",
        "keywords": [
            "Terson syndrome",
            "sub-inner limiting membrane hemorrhage",
            "ocular blunt trauma",
            "vitreous hemorrhage",
            "operation on vitreous"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "BI Chun-Chao",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "CHEN Tao",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "SUN Hong-Fen",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "ZHOU Rong-Le",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "ZHANG Zhi-Jun",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "ZHAO Bian-Fang",
                "org": "From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,Shaanxi Province,China"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2009
    },
    "M0dhYAuG": {
        "id": "M0dhYAuG",
        "title": "Influence of meclofenoxate hydrochloride on proliferation of human retinal pigment epithelial cells",
        "abstract": "Objective To study the effects of meclofenoxate hydrochloride on cultured human retinal pigment epithelial cells in vitro.Methods The effects of meclofenoxate hydrochloride on the proliferation of cultured hRPE cells were examined by tetrazolium salt(MTT) assay and AgNORs staining.Results Ranging from 10～1000 mg·L~ -1 ,meclofenoxate hydrochloride promoted hRPE proliferation and had a dose-dependent and time-dependent effect.AgNORs staining results showed the numbers of AgNORs in the nuclear increased when treated by meclofenoxate hydrochloride.Treated with 10 mg·L~ -1 meclofenoxate hydrochloride for 24 hours,the mean number of AgNORs was 2.0(P=0.029);and with 100 mg·L~ -1 meclofenoxate hydrochloride for 12 hours it was 2.0(P=0.029).Conclusion Meclofenoxate hydrochloride promoted human retinal pigment epithelial cells proliferation and had a dose-dependent and time-dependent effect.",
        "keywords": [
            "age-related macular degeneration",
            "retinal pigment epithelial cell",
            "meclofenoxate hydrochloride"
        ],
        "authors": [
            {
                "name": "NIU Chao",
                "org": "From the Institute of Ophthalmology of Chinese PLA,the Xijing Hospital,the Fourth Millitary Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "HUI Yan-Nian",
                "org": "From the Institute of Ophthalmology of Chinese PLA,the Xijing Hospital,the Fourth Millitary Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "WANG Yu-Sheng",
                "org": "From the Institute of Ophthalmology of Chinese PLA,the Xijing Hospital,the Fourth Millitary Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "WANG Jian-Zhou",
                "org": "From the Institute of Ophthalmology of Chinese PLA,the Xijing Hospital,the Fourth Millitary Medical University,Xi'an ,Shaanxi Province,China"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2006
    },
    "Fz2yjJdG": {
        "id": "Fz2yjJdG",
        "title": "Cyclopexy secondary to traumatic cyclodialysis cleft",
        "abstract": "Objective To investigate the detection,location and clinical effect of cyclopexy for traumatic cyclodialysis.Methods Fifteen cases(15 eyes) with traumatic cyclodialysis were undergone cyclopexy(cyclo-suture and cyclo-coagulation) by ultrasound biomicroscopy(UBM) combined with gonioscoy and myosis in order to finding cyclodialysis clefts.The operative method was selected according to position and extent of cyclodialysis cleft.Cyclocryosurgery and ciliary body suture were used for treatment.Results Fifteen cases with traumatic cyclodialysis were 360° cylodialysis.Myosis combined with UBM showed occult cyclodialysis cleft,and cyclopexy was found by gonioscope.The cleft amplitude is smaller than one o'clock.Among all cases,4 cases were undergone cyclo-coagulation,and 6 cases were done by direct cyclo-suture,and 5 cases did by cyclo-coagulation first and then did by cyclo-suture.No residual cleft was identified in UBM,and visual acuity improved except for one cases combined with traumatic neuroretinopathy.After operation,transcent intraocular pressure increased in 6 eyes,and 1 eye of which was higher than normal level at postoperative 1 month.Conclusions It is not crucial the cyclodialysis limiting but the cyclodialysis cleft,and through the accurate location of cleft in large extent diminution surgical amplitude.And it is essential of full-scale examination combined with myosis for finding occult cyclolysis cleft.",
        "keywords": [
            "cyclopexy",
            "traumatic cyclodialysis",
            "ultrasound biomicroscopy",
            "myosis",
            "cyclodialysis cleft",
            "gonioscope",
            "occult cyclodialysis cleft"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "CUI Hai-Long",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "XU Zhi-Guo",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "SONG Hu-Ping",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "ZHANG Qian",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "CHEN Jie",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "ZHANG Zhi-Jun",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            },
            {
                "name": "LIU Ya-Ru",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaanxi Province,China"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2011
    },
    "JM2C0p1c": {
        "id": "JM2C0p1c",
        "title": "Improvement of and investigation on a simplified model of retinal detachment in rabbits",
        "abstract": "Objective To improve a simplified model of retinal detachment in rabbits.MethodsTwenty-four eyes of 12 white rabbits were taken retinal detachment.Improvement were taken from anesthesia,out of vitreous to operative method.Conditions of natural reposition were observed.ResultsAfter improvement,vitreous could be removed of 0.8 mL to 1.2 mL.A total of 24 eyes were with complete retinal detachment,and 1 eye with vitreous hemorrhage.At 7 days after modeling,posterior pole of 9 eyes were with reposition,but perimeter were still separate,and the other eyes were with low detachment.At 14 days after modeling,retina became flat at posterior pole in all rabbit eyes,but retinal detachment was also found at perimeter,especially around slit pores.ConclusionsAfter improvement,the incidence of lens opacification can be induced.With removing more vitreous,the condition of retinal detachment can be retained for a longer time.",
        "keywords": [
            "rabbit",
            "model",
            "retinal detachment"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": ""
            },
            {
                "name": "WANG Lin-Lin",
                "org": ""
            },
            {
                "name": "WANG Xue",
                "org": ""
            },
            {
                "name": "LIU Yan",
                "org": ""
            },
            {
                "name": "HUI Yan-Nian",
                "org": ""
            },
            {
                "name": "MA Ji-Xian",
                "org": ""
            },
            {
                "name": "SU Jing-Bo",
                "org": ""
            },
            {
                "name": "SONG Hu-Ping",
                "org": ""
            },
            {
                "name": "XU Yuan",
                "org": ""
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2011
    },
    "rIXHd70u": {
        "id": "rIXHd70u",
        "title": "Endothelin-1 on intracellular free Calcium ion concentration in human retinal pigment epithelial cell",
        "abstract": "Objective To observe the effect of endothelin-1(ET-1) on intracellular free Calcium ion concentration([Ca2+]i) in retinal pigment epithelial cell(RPEC) cultured in vitro.Methods The fluo-3 penta-acetoxymethyl(fluo-3/AM) loaded RPEC were treated by 1×10-12-0.1×10-6 mol·L-1 ET-1.The changes of [Ca2+]i were observed and the effect of dexamethasone(DEX) and genistein on it were also evaluated using a laser scanning confocal microscope.Results The RPEC had a significant and dose dependent increase in [Ca2+]i under exposure to 1×10-12-0.1×10-6 mol·L-1 ET-1 solved by DMEM(F=8.228,P<0.01),did not in significant D-Hank solving ET-1(F=1.843,P>0.05).DEX and genistein suppressed the [Ca2+]i elevation induced by 1×10-9 mol·L-1 ET-1 in RPE(F=9.945,P<0.01;F=17.864,P<0.01,respectively).Conclusions ET-1 can stimulate [Ca2+]i elevation,which may mainly attribute to the entry of extracellular Calcium ion,and DEX and genistein can suppress the effect of ET-1.",
        "keywords": [
            "dexamethasone",
            "genistein",
            "intracellular free Calcium ion",
            "retinal pigment epithelial cell",
            "endothelin-1"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": ""
            },
            {
                "name": "HUI Yan-Nian",
                "org": ""
            },
            {
                "name": "WANG Hai-Yan",
                "org": ""
            },
            {
                "name": "BAI Jian-Wei",
                "org": ""
            },
            {
                "name": "XU Yuan",
                "org": ""
            },
            {
                "name": "WANG Yu-Sheng",
                "org": ""
            },
            {
                "name": "HU Dan",
                "org": ""
            },
            {
                "name": "MA Ji-Xian",
                "org": ""
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2008
    },
    "BLCTpT7g": {
        "id": "BLCTpT7g",
        "title": "Relationship of oscillatory potential between different axial length eyes and diabetic retinopathy eyes",
        "abstract": "Objective To compare the relationship of oscillatory potential between different axial length eyes and diabetic retinopathy eyes,investigate the change of retinal microcirculation in different axial length eyes.Methods This was a retrospective study.32 patients(32 eyes) with different axial length was collected to do electroretinogram,at the same time 18 patients(30 eyes) who was diabetic retinopathy proved by fundus fluorescein angiography was collected to do electroretinogram.Compare the relationship of oscillatory potential between two kind of eyes.Results ∑O of oscillatory potential in normal axial length was(143.81 ± 42.47) μv,in moderate eyes it was(93.93 ± 28.93) μv,in long eyes it was(68.43 ±17.99μv) ;∑O in Ⅲ stage of diabetic retinopathy was(108.19 ±21.21) μv,in Ⅳ stage of diabetic retinopathy it was(69.70 ± 16.63μv).There was statistical significance of those five group(F = 16.896,P < 0.01).∑O of moderate eyes had no statistical significance with diabetic retinopathy either Ⅲ stage or Ⅳ stage;∑O of long eyes had statistical significance with Ⅲ stage diabetic retinopathy,however there was not statistical significance between long eyes and Ⅳ stage diabetic retinopathy.Conclusion With the growth of axial length,oscillatory potential was fall-off.Retinal microcirculation in patients who were long eyes is lower than the patients in Ⅲ stage diabetic retinopathy.",
        "keywords": [
            "Eectrophysiology",
            "Aial length",
            "Dabetic retinopathy",
            "Ocillatory potential"
        ],
        "authors": [
            {
                "name": "LI Xing-yu",
                "org": ".Department of Ophthalmology,the Fourth Hosital of Xi'an,Shanxi ,China"
            },
            {
                "name": "CHEN Tao",
                "org": ".Department of Ophthalmology,the Fourth Hosital of Xi'an,Shanxi ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": ".Department of Ophthalmology,the Fourth Hosital of Xi'an,Shanxi ,China"
            }
        ],
        "venue": "Journal of Clinical Ophthalmology",
        "year": 2010
    },
    "f6OEb3nB": {
        "id": "f6OEb3nB",
        "title": "Observation of the efficacy of several treatment strategies on patients with nonarteritic anterior ischemic optic neuropathy at edema stage",
        "abstract": "Objective To evaluate the effectiveness of different comprehensive treatment strategies on patients with nonarteritic anterior ischemic optic neuropathy(NAION) at edema stage.Methods 352 cases(361 eyes) corresponded to the diagnosis criteria for NAION at acute stage and within 2 weeks,and judged by color photograph and FFA examination with optic disc edema,and detected by OCT were enrolled.Except D group(oral prednisone hormone therapy) 33 outpatient cases 33 eyes,and group E(internal medicine treatment) 31 outpatient cases of 32 eyes,patients were randomly divided into group A(methyl-prednisone vein impact joint vasodilators) 93 inpatient cases of 97 eyes,group B(methyl-prednisone impact joint dehydration reagent) 114 inpatient cases 116 eyes,C(methyl-prednisone impact joint mavericks blood to protein extracts) 81 inpatient cases of 83 eyes.All groups were analyzed by visual faction,photographic tomography and OCT after treatment within 14-16 days.Results After different comprehensive treatments on NAION in each group,the recovery in group C is better than group A,group B or group D from visual faction,photographic tomography and OCT changes observation,groups A and B compared with group D were no obvious difference;A,B,C,D groups compared with group E were statistically significant.Conclusions Methyl prednisone venous blood joint impact mavericks blood to protein extracts treatment on NAION at edema period is positive to improve visual function and revolving the optic disc edema,and is a safe,effective,comprehensive method to cure NAION.",
        "keywords": [
            "prednisone",
            "treatment outcome",
            "optic neuropathy",
            "ischemic",
            "actihaemyl",
            "anisodine"
        ],
        "authors": [
            {
                "name": "WANG Run-sheng",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "LV Pei-lin",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "CHANG Qian",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "LEI Xiao-qin",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "YU Jiang",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "DU Shan-shuang",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            },
            {
                "name": "ZHENG Bo",
                "org": ".Department of Ophthalmology,The Fourth Hospital of Xi'an,Xi'an ,China"
            }
        ],
        "venue": "Chinese Journal of Clinicians(Electronic Edition)",
        "year": 2011
    },
    "zCftOyQN": {
        "id": "zCftOyQN",
        "title": "Clinical analysis of 76 cases with complicated primary retinal detachment treated by minimal segmental buckling surgery",
        "abstract": "AIM:To analyse the efficacy and complications of complicated primary rhegmatogenous retinal detachment(RRD) treated with minimal segmental scleral buckling surgery. ·METHODS:This retrospective study included 76 consecutive cases of RRD which were operated on between October 2006 and October 2008 at department of ophthalmology,Xi’an No.4 Hospital with minimal scleral buckling surgery. Complicated primary rhegmatogenous retinal detachment was limited to slit pore in 2 quadrant or over and grades of vitreoretinopathy in C1-C2. This surgery referred to segmental buckle limited only to the area of retinal breaks with puncture of anterior chamber,and laser photocoagulation after retinal reattachment. All cases were studied including age of onset,course of disease,the extent of retinal detachment,the number and shape of retinal break,pre-and postoperative visual acuity,reattachment rate of operation and reoperation,reoperative rate,and complications after operation.·RESULTS:The mean age of the subjects was 31.92 years(range,19-62 years) ,and the mean course of disease was 7.4 months(range,2.0-36.5 months) ,the mean number of the quadrant of retinal detachment was 3.33,every retina had about 3.43 breaks in average(range,2-7) .Postoperative visual acuity had been im-proved in 48 cases. The primary and additional reattach-ment rate was 84% and 93%,respectively. The additional surgery rate was 38%. There were 17 cases of subjects who had encountered the postoperative complications,which included temporary diplopia in 3 cases,temporary high level of IOP in 12 cases and macular oedema in 2 cases.·CONCLUSION:Compared with the documentation,the treatment of complicated RRD with minimal buckling surgery could achieve the same anatomical and functional results as cerclage surgery,but the former has a higher rate of additional surgery than the latter,which means that we should be careful in the choice of operation indication in the treatment of the complicated primary RRD by minimal buckling surgery.",
        "keywords": [
            "scleral buckling surgery",
            "rhegmatogenous retinal detachment",
            "minimal",
            "complicated"
        ],
        "authors": [
            {
                "name": "Sheng-Li Zhang",
                "org": "Department of Ophthalmology,Weinan No.1 Hospital,Weinan ,Shaanxi Province,China"
            },
            {
                "name": "Hu-Ping Song",
                "org": "Department of Ophthalmology,Xi’an No.4 Hospital,Xi’an ,Shaanxi Province,China"
            },
            {
                "name": "Jian-Zhou Wang",
                "org": "Department of Ophthalmology,Xi’an No.4 Hospital,Xi’an ,Shaanxi Province,China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2009
    },
    "h98UNevU": {
        "id": "h98UNevU",
        "title": "Effects of mechanical stress on [Ca2+]i of human retinal pigment epithelial cells in vitro",
        "abstract": "• Aim: To observe the calcium flux of human retinal pigment epithelial cells (RPEs) during mechanical stress in vitro. • Methods: Ferric oxide microparticles, coated with collagen, were added into dishes containing substrate-attached RPEs. After incubation, the cell layer bounded with beads was laid in invariable magnetic field. Cultured human RPE cells were analyzed by using the fluorescence Ca2+ dye fluo-3/AM and laser scanning confocal microscope (LSCM) before and after force stimulation. • Results: Normal fluorescence in RPE cells was strong and distributed throughout the cells. The nucleus appeared to be more fluorescent than the cytoplasm. After force stimulation, a rapid increase in fluorescence intensity was observed, followed by a rapid decrease by adding MnCl2. There was no obvious difference in increased curve in cells preincubated with EGTA. By adding CaCl2, the fluorescence intensity increased again. Moreover, after force stimulation, the fluorescence intensity in cells preincubated with cytochalasin D increased over twice than that in normal cells. • Conclusion: Mechanical stress may increase the calcium influx of RPEs and initiate the release of intracellular calcium store. The calcium influx may be a signal before RPEs injury.",
        "keywords": [
            "Ca2+",
            "Force",
            "Retinal pigment epithelial cells"
        ],
        "authors": [
            {
                "name": "Xu Hou",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Yannian Hui",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Quanhong Han",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "XiaoGuang Zhang",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "ChangMei Guo",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2005
    },
    "EOMHh8Ay": {
        "id": "EOMHh8Ay",
        "title": "Autocrine adjustment of cultured human retinal pigment epithelial cells stimulated by endothelin-1 in vitro",
        "abstract": "Objective To investigate the autocrine of endothelin-1(ET-1) in human retinal pigment epithelial (hRPE) cells after stimulated by ET-1.Methods The hRPE cells were cultured and stimulated by 10-11 mol·L-1,10-9 mol·L-1 and 10-7 mol·L-1 of ET-1,the expression of ET-1 and nitric oxide synthase 1 (NOS1) was determined by immunocytochemistry and hybridization in situ,and the expressive value was quantitative analyzed by LeicaQ750 image analysator.The content of ET-1 and 6-Keto-PGF1α was quantified by radioimmunoassay in supernatant fluid.Results The expression of NOS1,ET-1 and ET-1 mRNA was weakly expressed in the RPE cells without treated by ET-1,and the expression of ET-1 and ET-1 mRNA was gradually enhanced after treated by 10-11 mol·L-1,10-9 mol·L-1 and 10-7 mol·L-1 ET-1 for 24 hours(F=9.511,P<0.01),and that of NOS1 also enhanced(F=16.113,P<0.01);And there were linear correlation in the expression of ET-1 mRNA and NOS1(r=0.685,P<0.05) after quanlified by image analysis.ET-1 caused a significant increase in levels compared with the control without treated by ET-1.There was a concentration-dependent significantly increase of secretion in ET-1 and 6-Keto-PGF1α in hRPE cells in response to 10-11 mol·L-1,10-9 mol·L-1 and 10-7 mol·L-1 ET-1(F=23.67,P<0.01 ;F=44.431,P<0.01,respectively),and there were linear correlation in the concentration of ET-1 and 6-Keto-PGF1α(r=0.85,P<0.01)in supernatant fluid.Conclusion The expression and release of ET-1 in hRPE cells is positive regulated by ET-1 differentially,the expression of NOS1 and secretion of 6-Keto-PGF1α may be related to negative regulation of ET-1.",
        "keywords": [
            "6-Keto-PGF1α",
            "nitric oxide synthase 1",
            "negative regulation",
            "autocrine",
            "positive regulation",
            "endothelin-1"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": "WANG Jian-Zhou now working in Department of Ophthalmology,the Fourth Hospital of Xi’an"
            },
            {
                "name": "HUI Yan-Nian",
                "org": "WANG Jian-Zhou now working in Department of Ophthalmology,the Fourth Hospital of Xi’an"
            },
            {
                "name": "WANG Yu-Sheng",
                "org": "WANG Jian-Zhou now working in Department of Ophthalmology,the Fourth Hospital of Xi’an"
            },
            {
                "name": "ZHANG Peng",
                "org": "WANG Jian-Zhou now working in Department of Ophthalmology,the Fourth Hospital of Xi’an"
            },
            {
                "name": "HOU Xu",
                "org": "WANG Jian-Zhou now working in Department of Ophthalmology,the Fourth Hospital of Xi’an"
            },
            {
                "name": "MA Ji-Xian",
                "org": "WANG Jian-Zhou now working in Department of Ophthalmology,the Fourth Hospital of Xi’an"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2007
    },
    "cboDj6mM": {
        "id": "cboDj6mM",
        "title": "The impact of periocular and intraocular in jection of triamcinolone acetonide on the prognosis of retinal detachment with choroi dal detachment",
        "abstract": "Objective To study the impact of periocular and intraocular injection of triamcinolone acetonide(TA) on the prognosis of retinal detachment with choroidal detachment.Methods Twenty-nine eyes of retinal detachment with choroidal detachment were treated by PPV along with triamcinolone acetonide(TA) intravitreal injections and silicone oil intraocular tamponade(group A,15 eyes),or TA periocular injections and C3F8 intraocular tamponade(group B,14 eyes).The two groups are all received 40 mg methylprednisolone periocular injections before surgery.After the surgery,silicone oil intraocular tamponade and 4 mg TA intravitreal injections were performed on group A,while C3F8 intraocular tamponade and 40 mg TA periocular injections on group B.Anatomic reattachment of the retina and the best-corrected visual acuity were measured.Results The rate of retinal reattachment was higher in the eyes of group A(86.67%) than that in group B(71.4%) in the first operation,but the difference has no statistical significance(P=0,390);the incidence rate of proliferative vitreoretinopathy (PVR) after the operation were higher in eyes of group B(28.57%) than that in group A(13.33%),what’s more,the severity of PVR is also higher.The functional outcome is that,11 eyes in group A and 10 eyes in group B achieved improvement in best corrected visual acuity(BCVA) after operation,and no significant difference between them.Conclusion PPV along with silicone oil intraocular tamponade and TA intravitreal injection were effective to the retinal reattachment of retinal detachment with choroidal detachment,and perhaps it is a better choice for the patients with other diseases like diabetes mellitus,hypertension and gastrointestinal ulcer.",
        "keywords": [
            "choroidal detachment",
            "vitrectomy",
            "retinal detachment"
        ],
        "authors": [
            {
                "name": "WEI Yong",
                "org": ""
            },
            {
                "name": "BI Chun-Chao",
                "org": ""
            },
            {
                "name": "ZHU Zhong-Qiao",
                "org": ""
            },
            {
                "name": "WANG Jian-Zhou",
                "org": ""
            },
            {
                "name": "ZHU Qun-Li",
                "org": ""
            },
            {
                "name": "WANG Run-Sheng",
                "org": ""
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2013
    },
    "b8IoYWMN": {
        "id": "b8IoYWMN",
        "title": "Clinical characteristics of retinal detachment associated with choroidal detachment and surgical treatment in retinal detachment associated with choroidal detachment",
        "abstract": "AIM:To analyze the clinical characteristics of retinal detachment associated with choroidal detachment and surgical treatment effectiveness of retinal detachment associated with choroidal detachment. ·METHODS:Six-four eyes of 64 patients with retinal detachment associated with choroidal detachment were enrolled. 26 eyes received scleral buckling;38 eyes re-ceived vitrectomy;No eye received cryocoagulation. The manifestations of those eyes and retinal reattachment rate was observed,and the clinical characteristics of retinal detachment associated with choroidal detachment were analyzed.·RESULTS:Fourty-one perent patients had high myopia(>-6.00D) . Tyndall sign and iris uveitis sign occured in all of those eyes. The percentage of retinal reattachment of patients who received scleral buckling was 73%,and of patients who received vitrectomy was 84%. ·CONCLUSION:High myopia eyes,Intraocular Lenses eyes and aphakia eyes were risk factors of retinal detachment associated with choroidal detachment. Laser photocoagulation after surgery instead of cryotherapy during surgery may enhance the percentage of retinal reattachment rate and reduce the risk of retinal detachment recurrence.",
        "keywords": [
            "choroidal detachment",
            "retinal detachment"
        ],
        "authors": [
            {
                "name": "Xi-Quan Zhao",
                "org": " Department of Ophthalmology,the Fourth Hospital of Xi’an,Xi’an ,Shaanxi Province,China"
            },
            {
                "name": "Jian-Zhou Wang",
                "org": " Department of Ophthalmology,the Fourth Hospital of Xi’an,Xi’an ,Shaanxi Province,China"
            },
            {
                "name": "Zhong-Qiao Zhu",
                "org": " Department of Ophthalmology,the Fourth Hospital of Xi’an,Xi’an ,Shaanxi Province,China"
            },
            {
                "name": "Xin-Guang Yang",
                "org": " Department of Ophthalmology,the Fourth Hospital of Xi’an,Xi’an ,Shaanxi Province,China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2009
    },
    "t9lzlbMq": {
        "id": "t9lzlbMq",
        "title": "The expression of endothelin-1 in magnetic bead coated retinal pigmental epithelial cells dragged by magnetic field",
        "abstract": "AIM: To investigate the expression of endothelin-1 (ET-1) in the human retinal pigment epithelial cells (hRPE cells) after traction. · METHODS: The hRPE cells attached to collagen-coated magnetic beads were tractioned under a fixed magnetic field and detected ET-1 expression in RPE cells in situ hybridization and immuno- histochemistry, and ET-1 content in the cell-conditioned medium by radio-immunoassay. · RESULTS: The shape of RPE cells tractioned by magnetic field changed with the prolonging time of traction. RPE cells obviously expressed ET-1 at 24 hours after traction. The content of ET-1 in the cell-conditioned medium also showed rising notably at 24 hours and 48 hours after 10 minutes, 30 minutes and 2 hours megnitic traction (P<0.05). · CONCLUSION: The traction enhances expression and secretion of ET-1 in the hRPE cells, indicating that the expression of ET-1 increases in the hRPE cells in the process of RRD. ·",
        "keywords": [
            "magnetic beads",
            "retinal pigment epithelial cells",
            "traction",
            "magnetic field",
            "endothelin-1"
        ],
        "authors": [
            {
                "name": "Jian-Zhou Wang",
                "org": "Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China;Department of Ophthalmology, the Fourth Hospital of Xi'an Ctiy, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Yan-Nian Hui",
                "org": "Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Xu Hou",
                "org": "Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Quan-Hong Han",
                "org": "Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Yu-Sheng Wang",
                "org": "Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Yuan Xu",
                "org": "Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2006
    },
    "1R0SlHCY": {
        "id": "1R0SlHCY",
        "title": "Inhibition of Ad-PEDF on neovascularization in rats with diabetic retinopathy",
        "abstract": "Objective To study the inhibition of pigment epithelium derived factor(PEDF) on neovascularization in rats with diabetic retinopathy after the injection of PEDF adenovirus carrier(Ad-PEDF).Methods PEDF viral vectors were structured,amplificated and depurated in vitro and then they were injected into rats’ vitreum with di-diabetes mellitus.PEDF expression was detected,the expression level and their inhibition on neovascularization were obeserved by comparing with the control group via immunohistochemistry,PAS staining and HE staining.Results In the group treated with Ad-PEDF,compared with control group,the PEDF expression markedly increased at all time points,and retinal neovascularization significantly reduced compared with control group via PAS staining and HE staining.Conclusion After the injection of Ad-PEDE,PEDF can suppress the formation and promote the regression of retinal neovascularization in rats with diabetic retinopathy.",
        "keywords": [
            "adenovirus",
            "neovascularization",
            "diabetic retinopathy",
            "pigment epithelium derived factor"
        ],
        "authors": [
            {
                "name": "BI Chun-Chao",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            },
            {
                "name": "WANG Rui",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            },
            {
                "name": "WANG Jian-Zhou",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            },
            {
                "name": "LEI Chun-Ling",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            },
            {
                "name": "DONG Xiao-Juan",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            },
            {
                "name": "WANG Xiao-Li",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            },
            {
                "name": "XUE Xiao-Hui",
                "org": " From the Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi' an ,Shaannxi Province,China"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2013
    },
    "PiY9Cp1p": {
        "id": "PiY9Cp1p",
        "title": "Effects of Defibrase with Light Quantum on Abnormally Hemorrheologic Behavior and Blood Lipid Level for Anterior Ischemic Optic Neuropathy and Central Retinal Vein Occlusion",
        "abstract": "Objective To investigate the effects of defibrase drugs with light quantum on the changes in hemorrheologic behavior and the level of blood lipid for anterior ischemic optic neuropathy(AION) and central retinal vein occlusion (CRVO). Methods A total of 132 patients with AION and CRVO,selected from the center of the Fourth Hospital of Xi'an,were divided into two groups by hemorrheologic behavior,each group involved 66 patients,randomly divided into treatment and control groups and males and females.Several items of hemorheology in 132 cases (66 males and 66 females) were treated with different methods with same drug to ameliorate the abnormal hemorrheologic blood behavior.Sixty six patients were given difibrase 10 U in 5% glucose solution iv drip,qd. Sixty six patients were given same doses defibrase in 5% glucose solution iv drip,qd,and at the same time light quantum was used. Hematocrit(HCT),fibrinogen,cholesterol,triglyceride (TG) and other items were examined before and after the therapy.After 10 day treatment,the changes in hemorheology and blood lipid were observed and compared respectively in each pair.The results in different groups is analyzed retrospectively. Results Indices of hemorheology in different methods with same drug were markedly reduced (P<0.05).The effect of treatment groups with light quantum was greater than that of control group.The indices of hemorheology such as high-shearing viscosity,low- shearing viscosity,red cell hematocrit,fibrinogen,and total cholesterol of blood lipid,were with significant difference compared with those of control group before and after treatment(P<0.01 or<0.05). Conclusions The drug treatment with light quantum on high blood viscosity in comparison with the control group is different for abnor- mally hemorrheologic behavior recovery.Choosing light as the suitable method with same drug is better for the therapeutic efficacy on treating AION and CRVO.",
        "keywords": [
            "Protease1",
            "High blood viscosity",
            "Anterior ischemic optic neuropathy",
            "Central retinal vein occlusion",
            "Light quantum"
        ],
        "authors": [
            {
                "name": "WANG Run-sheng",
                "org": " 1.Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,China 2.Department of Ophthalmology,the First Hospital of Xi'an"
            },
            {
                "name": "WANG Jian-zhou",
                "org": " 1.Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,China 2.Department of Ophthalmology,the First Hospital of Xi'an"
            },
            {
                "name": "WANG Xiao-di",
                "org": " 1.Department of Ophthalmology,the Fourth Hospital of Xi'an,Xi'an ,China 2.Department of Ophthalmology,the First Hospital of Xi'an"
            }
        ],
        "venue": "Chinese Journal of Laser Medicine & Surgery",
        "year": 2007
    },
    "CdL9ds4P": {
        "id": "CdL9ds4P",
        "title": "Therapeutic effect of two-step laser-induced chorioretinal venous anastomosis on central retinal vein occlusion in rabbits",
        "abstract": "AIM: To evaluate the therapeutic effect of two-step laser-induced chorioretinal venous anastomosis (LCRVA) in the treatment of central retinal vein occlusion (CRVO). METHODS: CRVO model was made by the photodynamic method in 22 rabbits (44 eyes). After one eye of the rabbits was randomly selected, we used multiple-frequency Nd:YAG and YAG laser devices to rupture the Burch's membrane and the adjacent venous wall to build the anastomosis. Therapeutic effect was determined by the results of fundus fluorescein angiography (FFA) and histopathologic examination four months later. RESULTS: CRVO model was made successfully in 34 eyes (77.3%), and 17 of them were treated with LCRVA at two different sites. The result of FFA revealed that the functional anastomosis was established in 8 eyes(47%, 11 sites) after 3-5wk. At postoperative 4mo, comparing the results of FFA and histopathologic examination of different groups, the impairment to the retina in the group with anastomosis established was found to be slighter than that in the CRVO group. CONCLUSION: Two-step LCRVA is a feasible and effective way in treating CRVO, and the establishment of the by-pass drainage can postpone the progression of the disease.",
        "keywords": [
            "laser-induced",
            "rabbits",
            "chorioretinal venous anastomosis"
        ],
        "authors": [
            {
                "name": "Li-Jun Chen",
                "org": " Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Yu-Sheng Wang",
                "org": " Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Ji-Xian Ma",
                "org": " Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Hai-Yan Wang",
                "org": " Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Peng Zhang",
                "org": " Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            },
            {
                "name": "Jian-Zhou Wang",
                "org": " Department of Ophthalmology, Xijing Hospital, the Fourth Military Medical University, Xi'an , Shaanxi Province, China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2006
    },
    "mzohr1qp": {
        "id": "mzohr1qp",
        "title": "Research advances of rhegmatogenous retinal detachment associated with choroidal detachment",
        "abstract": "• Rhegmatogenous retinal detachment associated with choroidal detachment is a special type of rhegmatogenous retinal detachment, with the characteristics of unknown origin and spontaneity, and there were many controversies in its occurrence, representation and treatment. The present paper will discuss some relevat questions based on the literature and it is expected to promote the understanding of this entity.",
        "keywords": [
            "Choroidal detachment",
            "Rhegmatogenous retinal detachment"
        ],
        "authors": [
            {
                "name": "Jian-Zhou Wang",
                "org": "Fourth Hospital of Xi'an City(Fourth Hospital of Xi'an City,The Fourth Hospital of Xi'an City),Xi'an,China"
            },
            {
                "name": "Yan-Nian Hui",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2008
    },
    "P45Xgwft": {
        "id": "P45Xgwft",
        "title": "Relationship between axial length and severity of diabetic retinopathy",
        "abstract": "Objective To investigate the relationship between axial length and severity of diabetic retinopathy(DR),and explore its clinical significance.Methods Eighty-four type-2 diabetic patients(160 eyes) were divided into three groups according to axial length:shorter than 24 mm(87 eyes),between 24 mm and 26 mm(48 eyes),longer than 26 mm(25 eyes).Visual acuity was examined in each group by international standard visual acuity chart,and the anterior segment was examined by slit lamp microscope.Fundus was examined by binocular indirect ophthalmoscope and fluorescein fundus angiography under dilated pupil.Axial length was measured by type-A ultrasound.The patients were divided into three groups according to the severity of DR:no DR,none proliferative DR(PDR) and PDR.The relationship between axial length and the severity of DR was analysis by Kendall test and Spearman's rank-correlation coefficient test.The comparison of PDR morbidity in three groups was performed by chi-square test.Results With the axial length increased,the severity of DR reduced,which showed the negative ranked relation,there were statistical differences(Kendall test,P<0.05,r=-0.34;Spearman's rank-correlation coefficient test,P<0.01,r=-0.367),and there was statistical difference in the incidence of PDR between axial length longer than 26 mm group and other two groups(χ2=34.457,P<0.05).Conclusions When the axial length becomes longer,the severity of DR reduces.As a protective factor of PDR,long axial length is significant to predict DR development and guide the treatment of DR.",
        "keywords": [
            "refractive error",
            "ocular axis",
            "diabetic retinopathy",
            "myopia"
        ],
        "authors": [
            {
                "name": "QU Chao-Yi",
                "org": " the Shaanxi Ophthalmic Medical Center,Xi'an Forth Hospital,Guangren Hospital Affiliated to School of Medicine,Xi'an Jiaotong University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "WANG Jian-Zhou",
                "org": " the Shaanxi Ophthalmic Medical Center,Xi'an Forth Hospital,Guangren Hospital Affiliated to School of Medicine,Xi'an Jiaotong University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "WANG Xin-Rong",
                "org": " the Shaanxi Ophthalmic Medical Center,Xi'an Forth Hospital,Guangren Hospital Affiliated to School of Medicine,Xi'an Jiaotong University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "ZHAO Hai-Mei",
                "org": " the Shaanxi Ophthalmic Medical Center,Xi'an Forth Hospital,Guangren Hospital Affiliated to School of Medicine,Xi'an Jiaotong University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "SONG Hu-Ping",
                "org": " the Shaanxi Ophthalmic Medical Center,Xi'an Forth Hospital,Guangren Hospital Affiliated to School of Medicine,Xi'an Jiaotong University,Xi'an ,Shaanxi Province,China"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2011
    },
    "nMyItCbR": {
        "id": "nMyItCbR",
        "title": "Expressive characteristics of endothelin-1 in rabbits with experimental retinal detachment",
        "abstract": "Objective To investigate the expression of endothelin-1(ET-1)in rabbits with experimental retinal detachment.Methods Eighteen Chinese albino rabbits(36 eyes)were divided into control group(2 rabbits,4 eyes)and experimental group(16 rabbits,32 eyes).Under the indirect ophthalmoscope,rabbits in experimental group were made a hole of retina at 6 o'clock under ambitus,and injected with 0.5 mL nature saline into the subretinal space by a glass-made pipette with a flat tip of 50 nm diameter.The eyeballs of 4 eyes(2 rabbits)in experimental group were taken out to make histological observation at postoperative half an hour,1 hour,3 hours,6 hours,24 hours,3 days,7 days and 14 days,respectively.The expression of ET-1 in retinas was measured by immunohistochemistry and situ hybridization.After drawing out vitreous body,lowering intraocular pressure and taking out eye ball,concentration of ET-1 was detected by radioimmunoassay.Results The retinal detachment showed in all 32 eyes of rabbits in experimental group,the detachment scope was from 3 to 9 o'clock.The concentration of ET-1 in vitreous body was detected at 3 hours after modeling,after gradually increase,there was a decrease.Immunohistochemical results showed that the concentration of ET-1 was found at 24 hours after modeling,while 3 hours after modeling by situ hybridization.Expression of ET-1 mRNA was found in each nervous layer of retina and RPE nucleus,and there was a light coloring in endochylema.Coloring of endochylema was gradually deepened at 24 hours after modeling,more obvious at 3 days after modeling and decreased at 7 days and 14 days after modeling.Conclusions ET-1 is a kind of earlier expressed cytokine in retinal detachment.Its expression has peak and low.Besides of lesion by retinal detachment,its fluctuation in subretinal fluid has relation with the damage of external shield and correlation among cytokines.",
        "keywords": [
            "immunohistochemistry",
            "endothelin",
            "situ hybridization",
            "radioimmunoassay",
            "retinal detachment"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": ""
            },
            {
                "name": "HUI Yan-Nian",
                "org": ""
            },
            {
                "name": "ZHOU Jian",
                "org": ""
            },
            {
                "name": "SONG Hu-Ping",
                "org": ""
            },
            {
                "name": "WANG Yu-Sheng",
                "org": ""
            },
            {
                "name": "XU Yuan",
                "org": ""
            },
            {
                "name": "MA Ji-Xian",
                "org": ""
            },
            {
                "name": "CHEN Li-Jun",
                "org": ""
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2010
    },
    "DAiI9eFr": {
        "id": "DAiI9eFr",
        "title": "Pathological changes and cellular proliferation in experimental retinal detachment",
        "abstract": "AIM:To explore the pathological changes and cellular proliferation in experimental retinal detachment.METHODS:Under the indirect ophthalmoscope,after withdrawing 0.5mL vitreous fluid,retinae of 32 eyes of albino rabbits were surgically detached by injecting 0.5mL normal saline into the subretinal space by a glass-made pipette with a flat tip of 50um diameter,and then studied by light microscopy and immunohistochemistry at detachment intervals ranging from 0.5hour to 14 days.RESULTS:The retinal detachment showed in all 32 eyes of experimental rabbits.The detached scope was from 3 to 9 o'clock or over a half of retina.The detached retinae remained for 3 to 14 days for spontaneous repositioning.Under ophthalmoscope,some retinal pigment epithelium(RPE) cells were seen at 3 days after retinal detachment;proliferation and macrophage-like hypertrophy of RPE cells were seen at 7 days;RPE presented changes of multiple Layers at 14 days,and it was found that macrophage-like RPE cells were originated from monolayer RPE cells,loafting and leaving for and connecting with outer segment of photoreceptor cells.Besides,proliferative cell nuclear antigens were expressed positive,so were keratin.CONCLUSION:The proliferative cells in subretinal space were mainly originated from RPE cells in some time after retinal detachment,and macrophage-like cells also derive from RPE.",
        "keywords": [
            "rabbit",
            "proliferative cell nulear antigen",
            "proliferation",
            "retinal pigment epithelial cell",
            "keratin",
            "retinal detachment"
        ],
        "authors": [
            {
                "name": "Jian-Zhou Wang",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Yan-Nian Hui",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Yu-Sheng Wang",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Li-Jun Chen",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Hai-Yan Wang",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Ji-Xian Ma",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Wei Zhao",
                "org": " Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2007
    },
    "T7zWTB8V": {
        "id": "T7zWTB8V",
        "title": "Regulatory effects of ninjurin-1 on adhesion of myeloid cells in the retina at the early stage of diabetic rats]",
        "abstract": "To investigate the regulatory effects of ninjurin-1 on adhesion of myeloid cells in the retina at the early stage of diabetic rats.Experimental study. The rat diabetic model was induced by intraperitoneal injection of streptozotocin. After 2 months of diabetes induction, 27 diabetic rats were randomly chosen and assigned to 3 groups, including diabetes and phosphate buffered saline (PBS) injection group (group B), diabetes and anti-Ninj-1 injection group (group C) and diabetes and anti-IgG injection group (group D), with 9 rats in each group. Nine age matched health rats were chosen as control group (group A). Retinal leukostasis was quantified with acridine orange leukocyte fluorography. Retinal myeloid cell infiltration activity was measured by enzyme linked immunosorbent assay of myeloperoxidase (MPO). The differences of the mean values among the four groups were analyzed by one-factor analysis of variance. The multiple comparisons of the mean values among the four groups were analyzed by LSD-t analysis.According to the results of the acridine orange leukocyte fluorography, the numbers of leukocyte adhesion in the four groups were 49.66 ± 13.51, 153.66 ± 20.43, 85.33 ± 15.03 and 156.33 ± 11.53, respectively. The differences among them were significant (F = 143.34, P = 0.000). The numbers of leukocyte adhesion in the group C were significantly lower than that in group B (P = 0.000, 95%CI: -82.68 - -53.98). The levels of retinal MPO in the four groups were (15.66 ± 2.08), (27.66 ± 2.51), (18.02 ± 2.01) and (26.66 ± 3.21) µg/L, respectively. The differences among them were significant (F = 17.61, P = 0.010). The level of retinal MPO in the group C was significantly lower than that in group B (P = 0.010, 95%CI: -14.37 - -4.95).Ninj-1 may play a role in the mediation of the adhesion of myeloid cell to the rat retina of early-stage of diabetes in vivo.",
        "keywords": [
            "myeloid cells",
            "adhesion",
            "diabetic retinopathy",
            "diabetes mellitus",
            "ninjurin-1",
            "experiment"
        ],
        "authors": [
            {
                "name": "Hu-ping Song",
                "org": "Department of Ophthalmology, Xi'an NO.4 Hospital, Xi'an 710004, China. songhpxian@163.com"
            },
            {
                "name": "Chun-ling Lei",
                "org": ""
            },
            {
                "name": "Yan-nian Hui",
                "org": ""
            },
            {
                "name": "Jian-zhou Wang",
                "org": ""
            },
            {
                "name": "Xiao-qin Lei",
                "org": ""
            },
            {
                "name": "Hua Ai",
                "org": ""
            }
        ],
        "venue": "[Zhonghua yan ke za zhi] Chinese journal of ophthalmology",
        "year": 2012
    },
    "CdUhrfzq": {
        "id": "CdUhrfzq",
        "title": "Effects of intravitreal injection of 1 mg dexamethasone on expression of endothelin-1 in the experimental retinal detachment",
        "abstract": "Objective To observe the effect of intravitreal injection of 1 mg dexamethasone(DEX) on the expression of endothelin-1(ET-1) in experimental retinal detachment.Methods Thirty-two albino rabbits (32 eyes) were divided into simple model groups and model and DEX groups of 4 intervals respectively.They were surgically detached by injecting 0.5 mL normal saline into subretinal space by a glass-made pipette with a flat tip of 50 μm diameter,and 1 mg DEX into the vitreous body in model and DEX groups,and then were studied with mouse anti-ERK and rabbits anti-ET-1 by immunohistochemistry,and ET-1 mRNA by situ hybridization and the ET-1 concentration in vitreous body by radioimmunoassay after drawing out 0.5 mL vitreous body fluid at detachment intervals of 0.5 hour,1 hour,3 hours and 6 hours.Results The retinal detachment showed in all 32 eyes of experimental rabbits,the detached scope was from 3 to 9 o'clock site.The ERK was phosphorylated and entered into the cell nucleus of RPE at 0.5 hour retinal detachment in the simple model groups while there was not any phosphorylated evidence at 4 intervals in the model and DEX groups.The concentration of ET-1 in vitreous body were detected at the 3rd hour and 6th hour in the simple model groups and did not in the model and DEX groups by radioimmunoassay.ET-1-like immunoreactivity did not appeared in the simple model groups and the model and DEX groups in neuroretina and RPE from 0.5 hour to 6 hours.The ET-1 mRNA expression were mainly situated in the nucleous of RPE cells and other cells of neural retina at the 3rd hour and 6th hour in the simple model groups,and did not in the model and DEX groups.Conclusion In this study of intravitreal injection of 1 mg DEX after retina being detached,DEX not only effect on the ET-1 entrance into subretinal fluid from blood,but on its expression in retina.",
        "keywords": [
            "rabbit",
            "dexamethasone",
            "endothelin",
            "retinal pigment epithelial cell",
            "retinal detachment"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": "From the Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "HUI Yan-Nian",
                "org": "From the Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "WANG Yu-Sheng",
                "org": "From the Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "ZHANG Peng",
                "org": "From the Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "MA JI-Xian",
                "org": "From the Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "HOU Xu",
                "org": "From the Department of Ophthalmology,Xijing Hospital,the Fourth Military Medical University,Xi'an ,Shaanxi Province,China"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2006
    },
    "Q8OhQsqR": {
        "id": "Q8OhQsqR",
        "title": "Endothelin-1 on human retinal pigment epithelial cells adhesion",
        "abstract": "Objective To investigate the adherent effects of endothelin-1(ET-1)on the human retinal pigment epithelial(hRPE)cells.Methods RPE attachment test and radioimmunoassay were used to detect adherent effects on hRPE cells and content change of 6-Keto-PGFα1 in different concentrations of ET-1.Results The RPE cell adhesion increased after stimulated by ET-1 doses from 10-11mol·L-1 to 10-9 mol·L-1 in a dose-dependent manner and decreased from 10-9mol·L-1 to 10-7 mol·L-1(F=6.352,P<0.01).The contents of 6-Keto-PGFα1 in RPE cell conditioned medium increased in a dose-dependent manner after stimulated by five ET-1 doses from 10-11mol·L-1 to 10-7 mol·L-1(F=33.929,P<0.01).Conclusion ET-1 stimulates the adhesion of RPE cells.The increase of 6-Keto-PGFα1 in the cell-conditioned medium may be respond to ET-1,and inhibits the effects of ET-1.",
        "keywords": [
            "endothelium",
            "retinal pigment epithelial cells",
            "adhesion"
        ],
        "authors": [
            {
                "name": "WANG Jian-Zhou",
                "org": "Department of Ophthalmology,the Fourth Hospital of Xi'an"
            },
            {
                "name": "HUI Yan-Nian",
                "org": "Department of Ophthalmology,the Fourth Hospital of Xi'an"
            },
            {
                "name": "WANG Yu-Sheng",
                "org": "Department of Ophthalmology,the Fourth Hospital of Xi'an"
            },
            {
                "name": "XU Yuan",
                "org": "Department of Ophthalmology,the Fourth Hospital of Xi'an"
            },
            {
                "name": "ZHANG Peng",
                "org": "Department of Ophthalmology,the Fourth Hospital of Xi'an"
            },
            {
                "name": "MA Ji-Xian",
                "org": "Department of Ophthalmology,the Fourth Hospital of Xi'an"
            }
        ],
        "venue": "Recent Advances in Ophthalmology",
        "year": 2007
    },
    "NjJmiCH4": {
        "id": "NjJmiCH4",
        "title": "Convenient use of binocular indirect ophthalmoscope after anterior chamber puncture in retinal detachment surgery with out drainage",
        "abstract": "• Aim: To improve the retinal detachment surgery without drainage. • Methods: Eighty-two cases with different detachment shapes and different hole positions of rhegmatogenous retinal detachment underwent retinal reattachment surgery without drainage. The intraocular pressure (IOP) was lowered through anterior chamber puncture for the sake of convenience to examination of retinal holes in the operation under indirect ophthalmoscope, scleral buckling and pneumatic retinopexy. • Results: None of 82 cases undergoing anterior chamber puncture had lens opacity, hyphema, infection or other complications. The rate of one-operation reattachment was 91% in varied types of retinal detachments. Retinas redetached in 4 cases of 75 patients who had successful retinal reattachment in one operation during the follow-up period of 6 to 12 months. • Conclusion: The method is safe, convenient and shortens the operation time and meanwhile it lowers the intraocular pressure in the surgery, which is convenient to operation under direct vision.",
        "keywords": [
            "Anterior chamber puncture",
            "Indirect ophthalmoscope",
            "Intraocular pressure",
            "Retinal detachment/surgery"
        ],
        "authors": [
            {
                "name": "Jian-Zhou Wang",
                "org": "Fourth Hospital of Xi'an City(Fourth Hospital of Xi'an City,The Fourth Hospital of Xi'an City),Xi'an,China"
            },
            {
                "name": "Yuan Xu",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Jun-Yan Li",
                "org": "Fourth Hospital of Xi'an City(Fourth Hospital of Xi'an City,The Fourth Hospital of Xi'an City),Xi'an,China"
            },
            {
                "name": "Zhi-Jun Zhang",
                "org": "Fourth Hospital of Xi'an City(Fourth Hospital of Xi'an City,The Fourth Hospital of Xi'an City),Xi'an,China"
            },
            {
                "name": "Hong-Fen Sun",
                "org": "Fourth Hospital of Xi'an City(Fourth Hospital of Xi'an City,The Fourth Hospital of Xi'an City),Xi'an,China"
            },
            {
                "name": "Xue-Mei Liang",
                "org": "Fourth Hospital of Xi'an City(Fourth Hospital of Xi'an City,The Fourth Hospital of Xi'an City),Xi'an,China"
            }
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2008
    },
    "lQQBXQt3": {
        "id": "lQQBXQt3",
        "title": "Combined forecasting models for wind energy forecasting: A case study in China",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ling xiao",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "yao dong",
                "org": ""
            },
            {
                "name": "jie wu",
                "org": ""
            }
        ],
        "venue": "Renewable & Sustainable Energy Reviews",
        "year": 2015
    },
    "lnRc0g5g": {
        "id": "lnRc0g5g",
        "title": "A case study on a hybrid wind speed forecasting method using BP neural network",
        "abstract": "Wind energy, which is intermittent by nature, can have a significant impact on power grid security, power system operation, and market economics, especially in areas with a high level of wind power penetration. Wind speed forecasting has been a vital part of wind farm planning and the operational planning of power grids with the aim of reducing greenhouse gas emissions. Improving the accuracy of wind speed forecasting algorithms has significant technological and economic impacts on these activities, and significant research efforts have addressed this aim recently. However, there is no single best forecasting algorithm that can be applied to any wind farm due to the fact that wind speed patterns can be very different between wind farms and are usually influenced by many factors that are location-specific and difficult to control. In this paper, we propose a new hybrid wind speed forecasting method based on a back-propagation (BP) neural network and the idea of eliminating seasonal effects from actual wind speed datasets using seasonal exponential adjustment. This method can forecast the daily average wind speed one year ahead with lower mean absolute errors compared to figures obtained without adjustment, as demonstrated by a case study conducted using a wind speed dataset collected from the Minqin area in China from 2001 to 2006.",
        "keywords": [
            "year-ahead daily average wind speed forecasting",
            "back-propagation neural network",
            "kolmogorov–smirnov test",
            "seasonal exponential adjustment",
            "wind speed forecasting",
            "wind speed",
            "mean absolute error",
            "back propagation",
            "wind energy",
            "wind power",
            "kolmogorov smirnov test",
            "seasonality",
            "neural network",
            "greenhouse gas emissions",
            "economic impact"
        ],
        "authors": [
            {
                "name": "Zhen-hai Guo",
                "org": "State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China"
            },
            {
                "name": "Jie Wu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Hai-yan Lu",
                "org": "Faculty of Engineering and Information Technology, University of Technology Sydney, Australia"
            },
            {
                "name": "Jian-zhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            }
        ],
        "venue": "Knowl.-Based Syst.",
        "year": 2011
    },
    "LTY9rrGA": {
        "id": "LTY9rrGA",
        "title": "Optimal parameters selection for BP neural network based on particle swarm optimization: A case study of wind speed forecasting",
        "abstract": "As a clean and renewable energy source, wind energy has been increasingly gaining global attention. Wind speed forecast is of great significance for wind energy domain: planning and design of wind farms, wind farm operation control, wind power prediction, power grid operation scheduling, and more. Many wind speed forecasting algorithms have been proposed to improve prediction accuracy. Few of them, however, have studied how to select input parameters carefully to achieve desired results. After introducing a Back Propagation neural network based on Particle Swam Optimization (PSO-BP), this paper details a method called IS-PSO-BP that combines PSO-BP with comprehensive parameter selection. The IS-PSO-BP is short for Input parameter Selection (IS)-PSO-BP, where IS stands for Input parameter Selection. To evaluate the forecast performance of proposed approach, this paper uses daily average wind speed data of Jiuquan and 6-hourly wind speed data of Yumen, Gansu of China from 2001 to 2006 as a case study. The experiment results clearly show that for these two particular datasets, the proposed method achieves much better forecast performance than the basic back propagation neural network and ARIMA model.",
        "keywords": [
            "wind energy",
            "wind speed forecast",
            "input parameter selection",
            "wind energy domain",
            "6-hourly wind speed data",
            "case study",
            "particle swarm optimization",
            "wind speed forecasting algorithm",
            "wind farm operation control",
            "daily average wind speed",
            "bp neural network",
            "optimal parameters selection",
            "wind farm",
            "wind power prediction",
            "wind speed"
        ],
        "authors": [
            {
                "name": "Chao Ren",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, PR China and Advanced Computing Lab, School of Information Science and Engineering, Lanzhou University, Lanzhou, Gansu, PR ..."
            },
            {
                "name": "Ning An",
                "org": "Advanced Computing Lab, School of Information Science and Engineering, Lanzhou University, Lanzhou, Gansu, PR China and Gerontechnology Lab, Hefei University of Technology, Hefei, Anhui, PR China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, PR China"
            },
            {
                "name": "Lian Li",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou, Gansu, PR China and Advanced Computing Lab, School of Information Science and Engineering, Lanzhou University, Lanzhou, Gansu, PR ..."
            },
            {
                "name": "Bin Hu",
                "org": "School of Information Science and Engineering, Lanzhou University, Lanzhou, Gansu, PR China"
            },
            {
                "name": "Duo Shang",
                "org": "College of Engineering and Applied Science, Stony Brook University, Stony Brook, NY, USA"
            }
        ],
        "venue": "Knowl.-Based Syst.",
        "year": 2014
    },
    "PD5XXdBo": {
        "id": "PD5XXdBo",
        "title": "A corrected hybrid approach for wind speed prediction in Hexi Corridor of China",
        "abstract": "Research highlights ► Design concept of combining SARIMA model with LSSVM algorithm is novel for wind speed time series prediction. ► On the issue of monthly wind speed prediction, the hybrid SARIMA–LSSVM model obtains more accurate forecasting values when compared to the single ARIMA model, the single SARIMA model, the single LSSVM model and the hybrid ARIMA–SVM model. ► The developed hybrid SARIMA–LSSVM model is simple but very efficient through the simulation process.",
        "keywords": [
            "wind speed",
            "hypothesis test",
            "hybrid sarima–lssvm model",
            "wind energy",
            "electricity generation",
            "support vector machine",
            "seasonality",
            "least squares support vector machine",
            "renewable resources"
        ],
        "authors": [
            {
                "name": "Zhenhai Guo",
                "org": "Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China"
            },
            {
                "name": "Jing Zhao",
                "org": ""
            },
            {
                "name": "Wenyu Zhang",
                "org": "College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Tianshui Road 222, Lanzhou 730000, Gansu Province, China"
            }
        ],
        "venue": "Energy",
        "year": 2011
    },
    "aXYM3mY5": {
        "id": "aXYM3mY5",
        "title": "Research and Application of a Novel Hybrid Model Based on Data Selection and Artificial Intelligence Algorithm for Short Term Load Forecasting.",
        "abstract": "Machine learning plays a vital role in several modern economic and industrial fields, and selecting an optimized machine learning method to improve time series’ forecasting accuracy is challenging. Advanced machine learning methods, e.g., the support vector regression (SVR) model, are widely employed in forecasting fields, but the individual SVR pays no attention to the significance of data selection, signal processing and optimization, which cannot always satisfy the requirements of time series forecasting. By preprocessing and analyzing the original time series, in this paper, a hybrid SVR model is developed, considering periodicity, trend and randomness, and combined with data selection, signal processing and an optimization algorithm for short-term load forecasting. Case studies of electricity power data from New South Wales and Singapore are regarded as exemplifications to estimate the performance of the developed novel model. The experimental results demonstrate that the proposed hybrid method is not only robust but also capable of achieving significant improvement compared with the traditional single models and can be an effective and efficient tool for power load forecasting.",
        "keywords": "",
        "authors": [
            {
                "name": "Wendong Yang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Rui Wang",
                "org": ""
            }
        ],
        "venue": "Entropy",
        "year": 2017
    },
    "Gz4cnkuZ": {
        "id": "Gz4cnkuZ",
        "title": "A seasonal hybrid procedure for electricity demand forecasting in China",
        "abstract": "Electricity is a special energy which is hard to store, so the electricity demand forecasting in China remains an important problem. This paper aims at developing an improved hybrid model for electricity demand in China, which takes the advantages of moving average procedure, combined method, hybrid model and adaptive particle swarm optimization algorithm, known as MA-C-WH. It is designed for making trend and seasonal adjustments which simultaneously presents the electricity demand forecasts. Four actual electricity demand time series in China power grids are selected to illustrate the proposed MA-C-WH model, and one existing seasonal autoregressive integrated moving average model (SARIMA) is selected to compare with the proposed model using the same data series. The results of popular forecasting precision indexes show that our proposed model is an effective forecasting technique for seasonal time series with nonlinear trend.",
        "keywords": [
            "forecasting",
            "electricity demand",
            "optimization",
            "seasonality",
            "demand forecasting",
            "indexation",
            "time series",
            "seasonal adjustment",
            "moving average"
        ],
        "authors": [
            {
                "name": "Suling Zhu",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, People’s Republic of China"
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Weigang Zhao",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, People’s Republic of China"
            },
            {
                "name": "Jujie Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, People’s Republic of China"
            }
        ],
        "venue": "Applied Energy",
        "year": 2011
    },
    "0LayQgbN": {
        "id": "0LayQgbN",
        "title": "The forecasting procedure for long-term wind speed in the Zhangye area",
        "abstract": "Energy crisis has made it urgent to find alternative energy sources for sustainable energy supply; wind energy is one of the attractive alternatives. Within a wind energy system, the wind speed is one key parameter; accurately forecasting of wind speed can minimize the scheduling errors and in turn increase the reliability of the electric power grid and reduce the power market ancillary service costs. This paper proposes a new hybrid model for long-term wind speed forecasting based on the first definite season index method and the Autoregressive Moving Average (ARMA) models or the Generalized Autoregressive Conditional Heteroskedasticity (GARCH) forecasting models. The forecasting errors are analyzed and compared with the ones obtained from the ARMA, GARCH model, and Support Vector Machine (SVM); the simulation process and results show that the developed method is simple and quite efficient for daily average wind speed forecasting of Hexi Corridor in China. Copyright © 2010 Zhenhai Guo, et al.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Zhenhai Guo",
                "org": "Institute of Atmospheric Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Atmospheric Physics),Beijing,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2010
    },
    "fTKY66lk": {
        "id": "fTKY66lk",
        "title": "Coal production forecast and low carbon policies in China",
        "abstract": "With rapid economic growth and industrial expansion, China consumes more coal than any other nation. Therefore, it is particularly crucial to forecast China's coal production to help managers make strategic decisions concerning China's policies intended to reduce carbon emissions and concerning the country's future needs for domestic and imported coal. Such decisions, which must consider results from forecasts, will have important national and international effects. This article proposes three improved forecasting models based on grey systems theory: the Discrete Grey Model (DGM), the Rolling DGM (RDGM), and the p value RDGM. We use the statistical data of coal production in China from 1949 to 2005 to validate the effectiveness of these improved models to forecast the data from 2006 to 2010. The performance of the models demonstrates that the p value RDGM has the best forecasting behaviour over this historical time period. Furthermore, this paper forecasts coal production from 2011 to 2015 and suggests some policies for reducing carbon and other emissions that accompany the rise in forecasted coal production. © 2011 Elsevier Ltd.",
        "keywords": [
            "carbon emissions reductions",
            "coal production",
            "grey theory",
            "economic growth",
            "carbon emissions"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jie Wu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Ren Mu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "He Jiang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Energy Policy",
        "year": 2011
    },
    "hmoEagmm": {
        "id": "hmoEagmm",
        "title": "A hybrid model for PM 2.5 forecasting based on ensemble empirical mode decomposition and a general regression neural network",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qingping zhou",
                "org": ""
            },
            {
                "name": "haiyan jiang",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "jianling zhou",
                "org": ""
            }
        ],
        "venue": "Science of The Total Environment",
        "year": 2014
    },
    "IMkqqeIx": {
        "id": "IMkqqeIx",
        "title": "Power generation and renewable potential in China",
        "abstract": "",
        "keywords": [
            "error correction model"
        ],
        "authors": [
            {
                "name": "jing zhao",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "zhongyue su",
                "org": ""
            }
        ],
        "venue": "Renewable & Sustainable Energy Reviews",
        "year": 2014
    },
    "NxfHsnnw": {
        "id": "NxfHsnnw",
        "title": "Swarm Intelligence-Based Hybrid Models for Short-Term Power Load Prediction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "shiqiang jin",
                "org": ""
            },
            {
                "name": "shanshan qin",
                "org": ""
            },
            {
                "name": "haiyan jiang",
                "org": ""
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2014
    },
    "rBMrhfn4": {
        "id": "rBMrhfn4",
        "title": "A Hybrid Evolutionary Algorithm Based on ACO and PSO for Real Estate Early Warning System",
        "abstract": "Recently some cities' investments on fix assets increase too fast that lead to a property bubble. In order to prevent the overheating of real estate investment, this paper presents a pre-warning system developed to monitor and provide pre-warning to the governmental decision makers in real estate market. In the overall structure plan, the warning classification system is the most important so that we make an innovation to it using the novel ACO-PSO-hybrid algorithm. The hybrid algorithm makes use of advantages of both ACO and PSO methods therefore it is of benefit in solving clustering problems. And the experiment results demonstrate that our algorithm is significantly better than K-means methods in terms of quality. It is adaptive, robust and efficient, achieving high autonomy, simplicity and efficiency. Therefore it can effectively provide early warning corresponding to reality so that the pre-warning system can provide useful information to regulate the property market.",
        "keywords": [
            "pattern clustering",
            "warning classification system",
            "hybrid evolutionary algorithm",
            "k-means method",
            "particle swarm optimization (pso)",
            "particle swarm optimisation",
            "pso method",
            "ant colonies optimization (aco)",
            "property bubble",
            "real estate early warning",
            "real estate market",
            "hybrid algorithm",
            "real estate early warning system",
            "pre-warning system",
            "real estate investment",
            "aco-pso-hybrid algorithm",
            "novel aco-pso-hybrid algorithm",
            "property market",
            "early warning system",
            "clustering algorithms",
            "indexes",
            "ant colony optimization",
            "algorithm design and analysis",
            "classification system",
            "decision maker",
            "principal component analysis",
            "real estate",
            "early warning",
            "classification algorithms",
            "k means"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            },
            {
                "name": "Jinxing Che",
                "org": ""
            },
            {
                "name": "Donghuai Sun",
                "org": ""
            }
        ],
        "venue": "Singapore",
        "year": 2008
    },
    "768so3cL": {
        "id": "768so3cL",
        "title": "Prediction by Integration of Phase Space Reconstruction and a Novel Evolutionary System under Deregulated Power Market",
        "abstract": "In deregulated power markets, forecasting electricity loads is one of the most essential tasks for system planning, operation and decision making. Based on an integration of two machine learning techniques: a hybrid evolutionary algorithm which combines PSO and Artificial Fish Swarm Algorithm Search approach based on test-sample error estimate criterion (PSO-AFSAS-TEE) and support vector regression (SVR), this paper proposes a novel evolutionary model for future electricity load forecasting. The proposed evolutionary model adopts an integrated architecture to optimize the prediction of time series. Firstly, the theory of Phase Space Reconstruction (PSR) technique was used for nonlinear dynamic system analysis and prediction with the chaotic load series. Then, a PSO-AFSAS-TEE evolutionary system is proposed to choose the parameters of SVR automatically in time series prediction. The effectiveness of the proposed model is demonstrated with actual data taken from the Australia Power Grid.",
        "keywords": [
            "evolutionary computation",
            "support vector machines",
            "time series",
            "learning artificial intelligence",
            "support vector regression",
            "sampling error",
            "machine learning",
            "time series prediction",
            "regression analysis",
            "electricity market"
        ],
        "authors": [
            {
                "name": "Wenyu Zhang",
                "org": ""
            },
            {
                "name": "Jinxing Che",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            }
        ],
        "venue": "WKDD",
        "year": 2009
    },
    "OoV50Vv5": {
        "id": "OoV50Vv5",
        "title": "Chaotic time series method combined with particle swarm optimization and trend adjustment for electricity demand forecasting",
        "abstract": "Electricity demand forecasting plays an important role in electric power systems planning. In this paper, nonlinear time series modeling technique is applied to analyze electricity demand. Firstly, the phase space, which describes the evolution of the behavior of a nonlinear system, is reconstructed using the delay embedding theorem. Secondly, the largest Lyapunov exponent forecasting method (LLEF) is employed to make a prediction of the chaotic time series. In order to overcome the limitation of LLEF, a weighted largest Lyapunov exponent forecasting method (WLLEF) is proposed to improve the prediction accuracy. The particle swarm optimization algorithm (PSO) is used to determine the optimal weight parameters of WLLEF. The trend adjustment technique is used to take into account the seasonal effects in the data set for improving the forecasting precision of WLLEF. A simulation is performed using a data set that was collected from the grid of New South Wales, Australia during May 14-18, 2007. The results show that chaotic characteristics obviously exist in electricity demand series and the proposed prediction model can effectively predict the electricity demand. The mean absolute relative error of the new prediction model is 2.48%, which is lower than the forecasting errors of existing methods.",
        "keywords": [
            "largest lyapunov exponent forecasting",
            "electricity demand series",
            "new prediction model",
            "forecasting precision",
            "prediction accuracy",
            "forecasting error",
            "proposed prediction model",
            "trend adjustment",
            "electricity demand forecasting",
            "particle swarm optimization",
            "forecasting method",
            "electricity demand",
            "particle swarm optimization algorithm",
            "chaotic time series",
            "chaotic time series method",
            "electric power system",
            "prediction model",
            "relative error",
            "phase space",
            "demand forecasting",
            "nonlinear system"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Dezhong Chi",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Jie Wu",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Hai-yan Lu",
                "org": "Faculty of Engineering and Information Technology, University of Technology, Sydney, Australia"
            }
        ],
        "venue": "Expert Syst. Appl.",
        "year": 2011
    },
    "Q1YjE6Bx": {
        "id": "Q1YjE6Bx",
        "title": "Supply chain safety stock quantity's fractal forecast and Study",
        "abstract": "Safety stock, a very important composing of the stock management, which is significant for reducing the cost and increasing interests for an enterprise, is the base of the setting of enterprise's stocks, so it is crucial for stock management to presume a rational and exact SS. In this paper, introducing fractal theory, a new method based on the fractal collage theorem and the iterative process of fractal interpolation functions was proposed to forecast the safety stock. Based on the fractal collage theorem, it uses the iterated function system whose attractor is close to the historical data to establish the fractional function, and set the forecasting model proposed according to the iterative process of fractional function. Then by an example the rationality and reliability of this method is verified, and the result show that it is helpful indeed to set the reasonable safety stock for enterprise. © 2008 IEEE.",
        "keywords": [
            "attractor",
            "forecast",
            "fractal theory",
            "iterated function system",
            "safety stock",
            "forecasting",
            "interpolation",
            "geometry",
            "fractals",
            "stock control",
            "supply chain management",
            "stock management",
            "supply chain",
            "supply chains",
            "artificial neural networks"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Yuanyuan Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            }
        ],
        "venue": "2008 International Conference on Wireless Communications, Networking and Mobile Computing, WiCOM 2008",
        "year": 2008
    },
    "5MWCygTP": {
        "id": "5MWCygTP",
        "title": "China’s natural gas production and consumption analysis based on the multicycle Hubbert model and rolling Grey model",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "haiyan jiang",
                "org": ""
            },
            {
                "name": "qingping zhou",
                "org": ""
            },
            {
                "name": "jie wu",
                "org": ""
            },
            {
                "name": "shanshan qin",
                "org": ""
            }
        ],
        "venue": "Renewable & Sustainable Energy Reviews",
        "year": 2016
    },
    "T8jHsuVf": {
        "id": "T8jHsuVf",
        "title": "Short term load forecasting technique based on the seasonal exponential adjustment method and the regression model",
        "abstract": "For an energy-limited economy system, it is crucial to forecast load demand accurately. This paper devotes to 1-week-ahead daily load forecasting approach in which load demand series are predicted by employing the information of days before being similar to that of the forecast day. As well as in many nonlinear systems, seasonal item and trend item are coexisting in load demand datasets. In this paper, the existing of the seasonal item in the load demand data series is firstly verified according to the Kendall τ correlation testing method. Then in the belief of the separate forecasting to the seasonal item and the trend item would improve the forecasting accuracy, hybrid models by combining seasonal exponential adjustment method (SEAM) with the regression methods are proposed in this paper, where SEAM and the regression models are employed to seasonal and trend items forecasting respectively. Comparisons of the quartile values as well as the mean absolute percentage error values demonstrate this forecasting technique can significantly improve the accuracy though models applied to the trend item forecasting are eleven different ones. This superior performance of this separate forecasting technique is further confirmed by the paired-sample T tests. © 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "kendall τ correlation",
            "quartile",
            "regression",
            "seasonal exponential adjustment method",
            "short term load forecasting"
        ],
        "authors": [
            {
                "name": "Jie Wu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            },
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Xiaoxiao Lu",
                "org": "Lanzhou Branch of Changzheng Engineering Co., Limited(),Lanzhou,China"
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2013
    },
    "q6tBHK3V": {
        "id": "q6tBHK3V",
        "title": "Artificial Combined Model Based on Hybrid Nonlinear Neural Network Models and Statistics Linear Models—Research and Application for Wind Speed Forecasting",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuewei Liu",
                "org": ""
            },
            {
                "name": "Shenghui Zhang",
                "org": ""
            },
            {
                "name": "Xuejun Chen",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            }
        ],
        "venue": "Sustainability",
        "year": 2018
    },
    "Nuqi65h3": {
        "id": "Nuqi65h3",
        "title": "An adaptive fuzzy combination model based on self-organizing map and support vector regression for electric load forecasting",
        "abstract": "Electric load forecasting is an important task in the daily operations of a power utility associated with energy transfer scheduling, unit commitment and load dispatch. Inspired by the various non-linearity of electric load data and the strong learning capacity of support vector regression (SVR) for small sample and balanced data, this paper presents an adaptive fuzzy combination model based on the self-organizing map (SOM), the SVR and the fuzzy inference method. The adaptive fuzzy combination model can effectively count for electric load forecasting with good accuracy and interpretability at the same time. The key idea behind the combination is to build a human-understandable knowledge base by constructing a fuzzy membership function for each homogeneous sub-population. The comparison of different mathematical models and the effectiveness of the presented model are shown by the real data of New South Wales electricity market. The obtained results confirm the validity of the developed model. © 2011 Elsevier Ltd.",
        "keywords": [
            "electric load prediction",
            "fuzzy membership function",
            "self-organizing map (som)",
            "support vector regression"
        ],
        "authors": [
            {
                "name": "Jinxing Che",
                "org": "Nanchang Institute of Technology(Nanchang Institute of Technology,NanChang Institute of Technology),Nanchang,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Guangfu Wang",
                "org": "East China Jiaotong Universtiy(East China Jiaotong Universtiy),,China"
            }
        ],
        "venue": "Energy",
        "year": 2012
    },
    "NshE0QEr": {
        "id": "NshE0QEr",
        "title": "Short-Term Electricity Price Forecasting Based on Novel SVM Using Artificial Fish Swarm Algorithm under Deregulated Power",
        "abstract": "In the competition paradigm of the electric power markets, both power producers and consumers need some price prediction tools in order to plan their bidding strategies. This paper studies the problem of modeling market clearing price forecasting in deregulated markets. And electricity price forecasting with support vector machines based on artificial fish swarm algorithm is provided. Except considering market clearing price (MCP) price influential factors such as previous competitive load, making-up price, competitive generating capacity etc, the past price data have been included as attributes in input parameters. Based on these influential factors, a novel optimization support vector regression (OSVR) forecasting model is presented. The proposed algorithm is more robust and reliable as compared to traditional approach and neural networks. The effectiveness of the proposed model is demonstrated with actual data taken from the Australia Power Grid, and the actual data are compared with the presented and neural networks methods.",
        "keywords": [
            "deregulated power",
            "optimisation",
            "electricity price forecasting",
            "market clearing price",
            "actual data",
            "australia power grid",
            "regression analysis",
            "electric power markets",
            "bidding strategies",
            "short-term electricity price forecasting",
            "market clearing price forecasting",
            "making-up price",
            "svm",
            "past price data",
            "optimization support vector regression",
            "competitive generating capacity etc",
            "power engineering computing",
            "artificial fish",
            "price prediction tool",
            "artificial fish swarm algorithm",
            "novel svm",
            "price influential factor",
            "power markets",
            "swarm algorithm",
            "neural networks methods",
            "support vector machines",
            "predictive models",
            "forecasting",
            "tuning",
            "support vector machine",
            "electric power",
            "time series analysis",
            "support vector regression",
            "artificial neural networks",
            "neural network"
        ],
        "authors": [
            {
                "name": "Dong-shan Gong",
                "org": ""
            },
            {
                "name": "Jin-xing Che",
                "org": ""
            },
            {
                "name": "Jian-zhou Wang",
                "org": ""
            },
            {
                "name": "Jin-zhao Liang",
                "org": ""
            }
        ],
        "venue": "Intelligent Information Technology Application, 2008. IITA '08. Second International Symposium",
        "year": 2008
    },
    "JOo2Yi2N": {
        "id": "JOo2Yi2N",
        "title": "The Research of Software Product Line Engineering Process and Its Integrated Development Environment Model",
        "abstract": "WiMAX security has two goals, one is to provide privacy across the wireless network and the other is to provide access control to the network. The security sub-layer of IEEE 802.16 employs an authenticated client/server key management protocol in which ...",
        "keywords": [
            "security sub-layer",
            "software product line engineering",
            "access control",
            "wireless network",
            "wimax security",
            "integrated development environment model",
            "authenticated client",
            "server key management protocol",
            "process model",
            "component",
            "software architecture",
            "industrial production",
            "product line engineering",
            "computer architecture",
            "data models",
            "software engineering",
            "development process",
            "product development",
            "computational modeling",
            "production",
            "programming"
        ],
        "authors": [
            {
                "name": "Jianli Dong",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Donghuai Sun",
                "org": ""
            },
            {
                "name": "Haiyan Lu",
                "org": ""
            }
        ],
        "venue": "ISCSCT (1)",
        "year": 2008
    },
    "hg02Uxr9": {
        "id": "hg02Uxr9",
        "title": "Time Series Forecasting Based on Novel Support Vector Machine Using Artificial Fish Swarm Algorithm",
        "abstract": "Time series analysis is an important and complex problem in machine learning. Support vector machine (SVM) has recently emerged as a powerful technique for solving problems in regression, but its performance mainly depends on the parameters selection of it. Parameters selection for SVM is very complex in nature and quite hard to solve by conventional optimization techniques, which constrains its application to some degree. In this paper, artificial fish swarm algorithm (AFSA) is proposed to choose the parameters of least squares support vector machine (LS-SVM) automatically in time series prediction. This method has been applied in a real Electricity Load Forecasting, the results show that the proposed approach has a better generalization performance and is also more accurate and effective than LS-SVM based on particle swarm optimization.",
        "keywords": [
            "generalization performance",
            "time series analysis",
            "optimisation",
            "afsa algorithm",
            "pso algorithm",
            "forecasting theory",
            "learning (artificial intelligence)",
            "complex problem",
            "vector machine",
            "electricity load forecasting",
            "least squares support vector machine (ls-svm)",
            "novel support",
            "support vector machine",
            "parameters selection",
            "artificial fish",
            "artificial fish swarm algorithm",
            "conventional optimization technique",
            "time series forecasting",
            "machine learning",
            "electricity",
            "swarm algorithm",
            "time series",
            "support vector machines",
            "squares support vector machine",
            "particle swarm optimization",
            "optimization",
            "time series prediction",
            "least squares support vector machine",
            "mathematical model",
            "learning artificial intelligence"
        ],
        "authors": [
            {
                "name": "Xuejun Chen",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Donghuai Sun",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            }
        ],
        "venue": "ICNC",
        "year": 2008
    },
    "e1yyhpzc": {
        "id": "e1yyhpzc",
        "title": "Multi-step forecasting for wind speed using a modified EMD-based artificial neural network model",
        "abstract": "In this paper, a modified EMD-FNN model (empirical mode decomposition (EMD) based feed-forward neural network (FNN) ensemble learning paradigm) is proposed for wind speed forecasting. The nonlinear and non-stationary original wind speed series is first decomposed into a finite and often small number of intrinsic mode functions (IMFs) and one residual series using EMD technique for a deep insight into the data structure. Then these sub-series except the high frequency are forecasted respectively by FNN whose input variables are selected by using partial autocorrelation function (PACF). Finally, the prediction results of the modeled IMFs and residual series are summed to formulate an ensemble forecast for the original wind speed series. Further more, the developed model shows the best accuracy comparing with basic FNN and unmodified EMD-based FNN through multi-step forecasting the mean monthly and daily wind speed in Zhangye of China. © 2011 Elsevier Ltd.",
        "keywords": [
            "empirical mode decomposition",
            "feed-forward neural network",
            "high frequency",
            "partial autocorrelation function",
            "wind speed multi-step forecasting",
            "feed forward neural network"
        ],
        "authors": [
            {
                "name": "Zhenhai Guo",
                "org": "Institute of Atmospheric Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Atmospheric Physics),Beijing,China"
            },
            {
                "name": "Weigang Zhao",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Renewable Energy",
        "year": 2012
    },
    "6Kw487tH": {
        "id": "6Kw487tH",
        "title": "A new hybrid model optimized by an intelligent optimization algorithm for wind speed forecasting",
        "abstract": "",
        "keywords": [
            "kalman filter",
            "arima"
        ],
        "authors": [
            {
                "name": "zhongyue su",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "haiyan lu",
                "org": ""
            },
            {
                "name": "ge zhao",
                "org": ""
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2014
    },
    "nbc6xJqy": {
        "id": "nbc6xJqy",
        "title": "Short-term wind speed forecasting based on a hybrid model",
        "abstract": "Wind power is currently one of the types of renewable energy with a large generation capacity. However, operation of wind power generation is very challenging because of the intermittent and stochastic nature of the wind speed. Wind speed forecasting is a very important part of wind parks management and the integration of wind power into electricity grids. As an artificial intelligence algorithm, radial basis function neural network (RBFNN) has been successfully applied into solving forecasting problems. In this paper, a novel approach named WTT-SAM-RBFNN for short-term wind speed forecasting is proposed by applying wavelet transform technique (WTT) into hybrid model which hybrids the seasonal adjustment method (SAM) and the RBFNN. Real data sets of wind speed in Northwest China are used to evaluate the forecasting accuracy of the proposed approach. To avoid the randomness caused by the RBFNN model or the RBFNN part of the hybrid model, all simulations in this study are repeated 30 times to get the average. Numerical results show that the WTT-SAM-RBFNN outperforms the persistence method (PM), multilayer perceptron neural network (MLP), RBFNN, hybrid SAM and RBFNN (SAM-RBFNN), and hybrid WTT and RBFNN (WTT-RBFNN). It is concluded that the proposed approach is an effective way to improve the prediction accuracy.",
        "keywords": [
            "rbfnn part",
            "hybrid model",
            "wind speed",
            "rbfnn model",
            "wind speed forecasting",
            "wind power generation",
            "short-term wind speed forecasting",
            "wind parks management",
            "wind power",
            "forecasting",
            "wavelet transform",
            "seasonal adjustment"
        ],
        "authors": [
            {
                "name": "Wenyu Zhang",
                "org": "Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China and Key Laboratory of Arid Climatic Change and  ..."
            },
            {
                "name": "Jujie Wang",
                "org": "Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China and Key Laboratory of Arid Climatic Change and  ..."
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Zengbao Zhao",
                "org": "Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China and Key Laboratory of Arid Climatic Change and  ..."
            },
            {
                "name": "Meng Tian",
                "org": "Key Laboratory for Semi-Arid Climate Change of the Ministry of Education, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China and Key Laboratory of Arid Climatic Change and  ..."
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2013
    },
    "aeCHHMiX": {
        "id": "aeCHHMiX",
        "title": "Price Forecasting of Supply Chain Product Based on Dynamic Fractal Dimension",
        "abstract": "Supply chain management (SCM) is an emerging field that has commanded attention and support from the industrial community. Demand forecast taking inventory into consideration is an important issue in SCM. This paper presents a novel computerized system for implementing the forecasting activities required in SCM. It can help the supply chain enterprises find hidden forms, trends and relationships in the date of supply chain by the dynamic fractal dimension of fractal theory, find that dynamic fractal dimension not only can overcome the delay of the existing technical analysis on the price forecasts, and but also can instruct the supply chain product prices in advance.",
        "keywords": [
            "important issue",
            "fractal theory",
            "forecasting activity",
            "dynamic fractal dimension",
            "price forecasting",
            "supply chain product price",
            "supply chain management",
            "supply chain",
            "supply chain enterprise",
            "supply chain product",
            "existing technical analysis",
            "demand forecast",
            "innovation management",
            "fractal dimension",
            "technical analysis",
            "fractals",
            "industrial engineering",
            "forecasting",
            "pricing",
            "demand forecasting",
            "information management"
        ],
        "authors": [
            {
                "name": "Jianli Dong",
                "org": ""
            },
            {
                "name": "Fudan Zeng",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Haiyan Lu",
                "org": ""
            }
        ],
        "venue": "ICIII '08 Proceedings of the 2008 International Conference on Information Management, Innovation Management and Industrial Engineering - Volume 02",
        "year": 2008
    },
    "d3wvku1v": {
        "id": "d3wvku1v",
        "title": "Optimal training subset in a support vector regression electric load forecasting model",
        "abstract": "This paper presents an optimal training subset for support vector regression (SVR) under deregulated power, which has a distinct advantage over SVR based on the full training set, since it solves the problem of large sample memory complexity O(N^2) and prevents over-fitting during unbalanced data regression. To compute the proposed optimal training subset, an approximation convexity optimization framework is constructed through coupling a penalty term for the size of the optimal training subset to the mean absolute percentage error (MAPE) for the full training set prediction. Furthermore, a special method for finding the approximate solution of the optimization goal function is introduced, which enables us to extract maximum information from the full training set and increases the overall prediction accuracy. The applicability and superiority of the presented algorithm are shown by the half-hourly electric load data (48 data points per day) experiments in New South Wales under three different sample sizes. Especially, the benefit of the developed methods for large data sets is demonstrated by the significantly less CPU running time.",
        "keywords": [
            "support vector regression",
            "electric load forecasting model",
            "proposed optimal training subset",
            "large data set",
            "different sample size",
            "unbalanced data regression",
            "data point",
            "full training set prediction",
            "full training set",
            "half-hourly electric load data",
            "optimal training subset",
            "approximation convexity optimization framework",
            "electric load",
            "prediction"
        ],
        "authors": [
            {
                "name": "JinXing Che",
                "org": "Department of Science, NanChang Institute Of Technology, NanChang, JiangXi 330099, China"
            },
            {
                "name": "JianZhou Wang",
                "org": "School of Mathematics and Statistics, LanZhou University, LanZhou, GanSu 730000, China"
            },
            {
                "name": "YuJuan Tang",
                "org": "Department of Science, NanChang Institute Of Technology, NanChang, JiangXi 330099, China"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2012
    },
    "iqdpxtXE": {
        "id": "iqdpxtXE",
        "title": "Detection, mining and forecasting of impact load in power load forecasting",
        "abstract": "People often try to smooth or eliminate impact load all together in traditional power load forecasting. This, however, could result in the loss of important hidden information. In other words, the impact load itself may be of particular important and they cause electric network collapse very easily. So there is a beforehand estimate to change and characteristic of power load, especially in impact load estimate, is the precondition that electric system carry through economy dispatching, reduce production cost and prevent electric network widespread blackout or collapse. This paper proposes a new method for electric deviate load and impact load detection, mining and forecasting. It solved the ''Masking effect'' and the problem on which the deviate data detection cannot be measured in deviate data analysis.",
        "keywords": [
            "power load",
            "data mining",
            "impact load",
            "load forecasting",
            "electric network",
            "impact load estimate",
            "electric deviate load",
            "deviate data",
            "electric system",
            "grey system",
            "electric network collapse",
            "traditional power load forecasting",
            "impact load detection",
            "electrical network",
            "data analysis"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Department of Mathematics, Lanzhou University, Lanzhou 730000, People's Republic of China"
            },
            {
                "name": "Zhixin Ma",
                "org": "Faculty of Information Science and Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China"
            },
            {
                "name": "Lian Li",
                "org": "Faculty of Information Science and Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2005
    },
    "LQCvOqwO": {
        "id": "LQCvOqwO",
        "title": "Forecasting solar radiation using an optimized hybrid model by Cuckoo Search algorithm",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "he jiang",
                "org": ""
            },
            {
                "name": "yujie wu",
                "org": ""
            },
            {
                "name": "yao dong",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "tBpVxqAC": {
        "id": "tBpVxqAC",
        "title": "Combined modeling for electric load forecasting with adaptive particle swarm optimization",
        "abstract": "Electric load forecasting is crucial for managing electric power systems economically and safely. This paper presents a new combined model for electric load forecasting based on the seasonal ARIMA forecasting model, the seasonal exponential smoothing model and the weighted support vector machines. The combined model can effectively count for the seasonality and nonlinearity shown in the electric load data and give more accurate forecasting results. The adaptive particle swarm optimization is employed to optimize the weight coefficients in the combined forecasting model. The proposed combined model has been compared with the individual models and the other combined model reported in the literature and its results are promising.",
        "keywords": [
            "forecasting accuracy",
            "load forecasting",
            "adaptive particle swarm optimization",
            "combined model",
            "seasonality",
            "support vector machine",
            "exponential smoothing",
            "electric power system"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics & Statistics, Lanzhou University, Tianshuilu 222, Lanzhou, China"
            },
            {
                "name": "Suling Zhu",
                "org": ""
            },
            {
                "name": "Wenyu Zhang",
                "org": "College of Atmospheric Sciences, Lanzhou University, Lanzhou, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "Faculty of Engineering and Information Technology, University of Technology, Sydney, Australia"
            }
        ],
        "venue": "Energy",
        "year": 2010
    },
    "DSpfBgaD": {
        "id": "DSpfBgaD",
        "title": "A trend fixed on firstly and seasonal adjustment model combined with the [epsilon]-SVR for short-term forecasting of electricity demand",
        "abstract": "",
        "keywords": [
            "moving average",
            "analysis of variance",
            "demand forecasting",
            "seasonality",
            "verification and validation",
            "seasonal adjustment",
            "seasonal variation"
        ],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": "lanzhou university"
            },
            {
                "name": "wenjin zhu",
                "org": "lanzhou university"
            },
            {
                "name": "wenyu zhang",
                "org": "lanzhou university"
            },
            {
                "name": "donghuai sun",
                "org": "lanzhou university"
            }
        ],
        "venue": "Energy Policy",
        "year": 2009
    },
    "HfAZipsu": {
        "id": "HfAZipsu",
        "title": "A hybrid model based on data preprocessing for electrical power forecasting",
        "abstract": "",
        "keywords": [
            "model selection"
        ],
        "authors": [
            {
                "name": "liye xiao",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "xuesong yang",
                "org": ""
            }
        ],
        "venue": "International Journal of Electrical Power & Energy Systems",
        "year": 2015
    },
    "sZxeZGMk": {
        "id": "sZxeZGMk",
        "title": "A ROLLING GREY MODEL OPTIMIZED BY PARTICLE SWARM OPTIMIZATION IN ECONOMIC PREDICTION: PSO-RGM IN ECONOMIC PREDICTION",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "li liu",
                "org": ""
            },
            {
                "name": "qianru wang",
                "org": ""
            },
            {
                "name": "ming liu",
                "org": ""
            }
        ],
        "venue": "computational intelligence",
        "year": 2014
    },
    "LcYJdoCa": {
        "id": "LcYJdoCa",
        "title": "The model of chaotic sequences based on adaptive particle swarm optimization arithmetic combined with seasonal term",
        "abstract": "Within a competitive electric power market, electricity price is one of the core elements, which is crucial to all the market participants. Accurately forecasting of electricity price becomes highly desirable. This paper propose a forecasting model of electricity price using chaotic sequences for forecasting of short term electricity price in the Australian power market. One modified model is applies seasonal adjustment and another modified model is employed seasonal adjustment and adaptive particle swarm optimization (APSO) that determines the parameters for the chaotic system. The experimental results show that the proposed methods performs noticeably better than the traditional chaotic algorithm. © 2011 Elsevier Inc.",
        "keywords": [
            "Adaptive particle warm optimization arithmetic",
            "Adding-weight one-rank local-region prediction method",
            "Chaotic theory",
            "Seasonal adjustment"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            },
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Dezhong Chi",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2012
    },
    "BQPkFCLO": {
        "id": "BQPkFCLO",
        "title": "Short-term effects of air pollution on lower respiratory diseases and forecasting by the group method of data handling",
        "abstract": "Risk of lower respiratory diseases was significantly correlated with levels of monthly average concentration of SO 2; NO 2 and association rules have high lifts. In view of Lanzhou's special geographical location, taking into account the impact of different seasons, especially for the winter, the relations between air pollutants and the respiratory disease deserve further study. In this study the monthly average concentration of SO 2, NO 2, PM 10 and the monthly number of people who in hospital because of lower respiratory disease from January 2001 to December 2005 are grouped equidistant and considered as the terms of transactions. Then based on the relational algebraic theory we employed the optimization relation association rule to mine the association rules of the transactions. Based on the association rules revealing the effects of air pollutants on the lower respiratory disease, we forecast the number of person who suffered from lower respiratory disease by the group method of data handling (GMDH) to reveal the risk and give a consultation to the hospital in Xigu District, the most seriously polluted district in Lanzhou. The data and analysis indicate that individuals may be susceptible to the short-term effects of pollution and thus suffer from lower respiratory diseases and this effect presents seasonal. © 2012 Elsevier Ltd.",
        "keywords": [
            "air pollution",
            "association rules",
            "gmdh",
            "lanzhou",
            "lower respiratory diseases",
            "orar"
        ],
        "authors": [
            {
                "name": "Wenjin Zhu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Wenyu Zhang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Atmospheric Environment",
        "year": 2012
    },
    "mMrSmf72": {
        "id": "mMrSmf72",
        "title": "A novel hybrid model based on multi-objective Harris hawks optimization algorithm for daily PM2.5 and PM10 forecasting.",
        "abstract": "  High levels of air pollution may seriously affect people's living environment and even endanger their lives. In order to reduce air pollution concentrations, and warn the public before the occurrence of hazardous air pollutants, it is urgent to design an accurate and reliable air pollutant forecasting model. However, most previous research have many deficiencies, such as ignoring the importance of predictive stability, and poor initial parameters and so on, which have significantly effect on the performance of air pollution prediction. Therefore, to address these issues, a novel hybrid model is proposed in this study. Specifically, a powerful data preprocessing techniques is applied to decompose the original time series into different modes from low- frequency to high- frequency. Next, a new multi-objective algorithm called MOHHO is first developed in this study, which are introduced to tune the parameters of ELM model with high forecasting accuracy and stability for air pollution series prediction, simultaneously. And the optimized ELM model is used to perform the time series prediction. Finally, a scientific and robust evaluation system including several error criteria, benchmark models, and several experiments using six air pollutant concentrations time series from three cities in China is designed to perform a compressive assessment for the presented hybrid forecasting model. Experimental results indicate that the proposed hybrid model can guarantee a more stable and higher predictive performance compared to others, whose superior prediction ability may help to develop effective plans for air pollutant emissions and prevent health problems caused by air pollution. ",
        "keywords": "",
        "authors": [
            {
                "name": "Pei Du",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Yan Hao",
                "org": ""
            },
            {
                "name": "Tong Niu",
                "org": ""
            },
            {
                "name": "Wendong Yang",
                "org": ""
            }
        ],
        "venue": "arXiv: Learning",
        "year": 2019
    },
    "Iz5fBnC0": {
        "id": "Iz5fBnC0",
        "title": "Multi-step forecasting for wind speed using a modified EMD-based artificial neural network",
        "abstract": "Highlights ► Multi-step forecasting for nonlinear and non-stationary wind speed series. ► EMD technique is used for a deep insight into the data structure. ► Use the robust FNN model for forecasting the sub-series obtained from EMD. ► PACF is used to select the input variables for FNNs. ► Get rid of the high frequency to improve forecasting precision.",
        "keywords": [
            "Feed-forward neural network",
            "Empirical mode decomposition",
            "Partial autocorrelation function",
            "High frequency",
            "Wind speed multi-step forecasting"
        ],
        "authors": [
            {
                "name": "Zhenhai Guo",
                "org": "Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China"
            },
            {
                "name": "Weigang Zhao",
                "org": ""
            },
            {
                "name": "Haiyan Lu",
                "org": "Department of Software Engineering, University of Technology Sydney, Australia"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics & Statistics, Lanzhou University, Lanzhou 730000, China"
            }
        ],
        "venue": "Renewable Energy",
        "year": ""
    },
    "Je5Zaxfl": {
        "id": "Je5Zaxfl",
        "title": "Research on Combined Model Based on Multi-Objective Optimization and Application in Wind Speed Forecast",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Shenghui Zhang",
                "org": ""
            },
            {
                "name": "Yuewei Liu",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Chen Wang",
                "org": ""
            }
        ],
        "venue": "Applied Sciences",
        "year": 2019
    },
    "Cn7Ufi6X": {
        "id": "Cn7Ufi6X",
        "title": "Application of the largest Lyapunov exponent and non-linear fractal extrapolation algorithm to short-term load forecasting",
        "abstract": "Precise short-term load forecasting (STLF) plays a key role in unit commitment, maintenance and economic dispatch problems. Employing a subjective and arbitrary predictive step size is one of the most important factors causing the low forecasting accuracy. To solve this problem, the largest Lyapunov exponent is adopted to estimate the maximal predictive step size so that the step size in the forecasting is no more than this maximal one. In addition, in this paper a seldom used forecasting model, which is based on the non-linear fractal extrapolation (NLFE) algorithm, is considered to develop the accuracy of predictions. The suitability and superiority of the two solutions are illustrated through an application to real load forecasting using New South Wales electricity load data from the Australian National Electricity Market. Meanwhile, three forecasting models: the gray model, the seasonal autoregressive integrated moving average approach and the support vector machine method, which received high approval in STLF, are selected to compare with the NLFE algorithm. Comparison results also show that the NLFE model is outstanding, effective, practical and feasible. © 2012 Elsevier Ltd. All rights reserved.",
        "keywords": [],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Ruiling Jia",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Weigang Zhao",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jie Wu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2012
    },
    "UO9zWHHE": {
        "id": "UO9zWHHE",
        "title": "Combining principal component analysis and fuzzy cluster analysis for China's oil security",
        "abstract": "It is significant to evaluate the situations of oil security for taking national oil security measures, because very important relationships exist between the oil security and the national security. A novel combined method is presented in this paper, which is based on using principal component analysis (PCA) and fuzzy cluster analysis (FCA) modeling. It is used for assessing oil security. In this paper, the data of 13 years is taken as sample and 10 indexes are selected to constitute an evaluation system for oil security. PCA is used for reducing the dimensions of indexes, and the new indexes are formed for oil security. Then FCA is used for classifying the 13 samples. At last a dialed analysis is made and some suggestions are put forward to ensure oil security. © 2008 IET.",
        "keywords": [],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Suling Zhu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            }
        ],
        "venue": "IET Seminar Digest",
        "year": 2008
    },
    "0DH3sdnl": {
        "id": "0DH3sdnl",
        "title": "Forecasting stock indices with back propagation neural network",
        "abstract": "Stock prices as time series are non-stationary and highly-noisy due to the fact that stock markets are affected by a variety of factors. Predicting stock price or index with the noisy data directly is usually subject to large errors. In this paper, we propose a new approach to forecasting the stock prices via the Wavelet De-noising-based Back Propagation (WDBP) neural network. An effective algorithm for predicting the stock prices is developed. The monthly closing price data with the Shanghai Composite Index from January 1993 to December 2009 are used to illustrate the application of the WDBP neural network based algorithm in predicting the stock index. To show the advantage of this new approach for stock index forecast, the WDBP neural network is compared with the single Back Propagation (BP) neural network using the real data set.",
        "keywords": [
            "wavelet de-noising",
            "wdbp neural network",
            "bp neural network",
            "stock prices",
            "neural network",
            "indexation",
            "time series",
            "back propagation"
        ],
        "authors": [
            {
                "name": "Jian-Zhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Ju-Jie Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Zhe-George Zhang",
                "org": "Western Washington University(Western Washington University),Bellingham,United States"
            },
            {
                "name": "Shu-Po Guo",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            }
        ],
        "venue": "Expert Syst. Appl.",
        "year": 2011
    },
    "O3FNrD1I": {
        "id": "O3FNrD1I",
        "title": "A novel hybrid model based on artificial neural networks for solar radiation prediction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yujie wu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            }
        ],
        "venue": "Renewable Energy",
        "year": 2016
    },
    "YYeGJVP0": {
        "id": "YYeGJVP0",
        "title": "A ROLLING GREY MODEL OPTIMIZED BY PARTICLE SWARM OPTIMIZATION IN ECONOMIC PREDICTION",
        "abstract": "Grey system theory has been widely used to forecast the economic data that are often nonlinear, irregular, and nonstationary. Current forecasting models based on grey system theory could adapt to various economic time series data. However, these models ignored the importance of the model parameter optimization and the use of recent data, which lead to poor forecasting accuracy. In this article, we propose a novel forecasting model, called particle swarm optimization rolling grey model PSO-RGM1,1, based on a rolling mechanism GM with optimized parameters by using the particle swarm optimization algorithm. The simple model is shown to be very effective in forecasting the tertiary industry data sequences, which are short and noisy but regular in secular trend. The experimental results show that PSO-RGM1,1 outperforms other commonly used forecasting models on three real economic data sets. Our empirical study shows that PSO is found to be the best overall algorithm to optimize the parameter of RGM compared with other well-known metaheuristics. Furthermore, we evaluated other variant PSOs and found that single particle PSO outperforms others overall in terms of prediction accuracy, convergence speed, and degree of certainty.",
        "keywords": [
            "economic forecasting",
            "particle swarm optimization"
        ],
        "authors": [
            {
                "name": "li liu",
                "org": "chongqing university"
            },
            {
                "name": "qianru wang",
                "org": "lanzhou university"
            },
            {
                "name": "jianzhou wang",
                "org": "lanzhou university"
            },
            {
                "name": "ming liu",
                "org": "university of sydney"
            }
        ],
        "venue": "Computational Intelligence",
        "year": 2014
    },
    "NViWpsEL": {
        "id": "NViWpsEL",
        "title": "Artificial Intelligence and Data Mining 2014",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "fuding xie",
                "org": ""
            },
            {
                "name": "suohai fan",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "helen lu",
                "org": ""
            },
            {
                "name": "caihong li",
                "org": ""
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2014
    },
    "0ppvk96o": {
        "id": "0ppvk96o",
        "title": "Can China realize its carbon emission reduction goal in 2020: From the perspective of thermal power development",
        "abstract": "",
        "keywords": [
            "thermal power",
            "china"
        ],
        "authors": [
            {
                "name": "liwei liu",
                "org": ""
            },
            {
                "name": "haijing zong",
                "org": ""
            },
            {
                "name": "erdong zhao",
                "org": ""
            },
            {
                "name": "chuxiang chen",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            }
        ],
        "venue": "Applied Energy",
        "year": 2014
    },
    "GOqNXpx2": {
        "id": "GOqNXpx2",
        "title": "Research on Innovative Education Thoughts and Teaching Methods for China Universities",
        "abstract": "The age of knowledge-based economy is a full new information age when economic resource is based on knowledge, establishing the innovative education thoughts and innovative talent training mode adapted to the age will be an important topic for higher education to face and resolve. Based on the background of knowledge-based economy and information society, and combining with the features and current status of china universities education and talent training, the university innovating educational ideas and talent training methods are proposed and systematically discussed.",
        "keywords": [
            "innovative education thought",
            "higher education",
            "talent training method",
            "innovative talent training mode",
            "talent training",
            "current status",
            "full new information age",
            "innovative education thoughts",
            "china universities education",
            "information society",
            "china universities",
            "teaching methods",
            "knowledge-based economy",
            "knowledge based systems",
            "information age",
            "teaching",
            "knowledge based economy"
        ],
        "authors": [
            {
                "name": "Jianli Dong",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            }
        ],
        "venue": "ICIII '09 Proceedings of the 2009 International Conference on Information Management, Innovation Management and Industrial Engineering - Volume 03",
        "year": 2009
    },
    "XgGZytuV": {
        "id": "XgGZytuV",
        "title": "Outlier-robust hybrid electricity price forecasting model for electricity market management",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Wendong Yang",
                "org": ""
            },
            {
                "name": "Pei Du",
                "org": ""
            },
            {
                "name": "Tong Niu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2019
    },
    "9f8kMahz": {
        "id": "9f8kMahz",
        "title": "A Hybrid Forecasting Model Based on Bivariate Division and a Backpropagation Artificial Neural Network Optimized by Chaos Particle Swarm Optimization for Day-Ahead Electricity Price",
        "abstract": "In the electricity market, the electricity price plays an inevitable role. Nevertheless, accurate price forecasting, a vital factor affecting both government regulatory agencies and public power companies, remains a huge challenge and a critical problem. Determining how to address the accurate forecasting problem becomes an even more significant task in an era in which electricity is increasingly important. Based on the chaos particle swarm optimization (CPSO), the backpropagation artificial neural network (BPANN), and the idea of bivariate division, this paper proposes a bivariate division BPANN (BD-BPANN) method and the CPSO-BD-BPANN method for forecasting electricity price. The former method creatively transforms the electricity demand and price to be a new variable, named DV, which is calculated using the division principle, to forecast the day-ahead electricity by multiplying the forecasted values of the DVs and forecasted values of the demand. Next, to improve the accuracy of BD-BPANN, chaos particle swarm optimization and BD-BPANN are synthesized to form a novel model, CPSO-BD-BPANN. In this study, CPSO is utilized to optimize the initial parameters of BD-BPANN to make its output more stable than the original model. Finally, two forecasting strategies are proposed regarding different situations.",
        "keywords": [],
        "authors": [
            {
                "name": "zhilong wang",
                "org": "Lanzhou Inst Technol, Dept Basic Courses, Lanzhou 730050, Peoples R China"
            },
            {
                "name": "feng liu",
                "org": "Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China"
            },
            {
                "name": "jie wu",
                "org": "Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China"
            },
            {
                "name": "jianzhou wang",
                "org": "Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2014
    },
    "MvNdkyKJ": {
        "id": "MvNdkyKJ",
        "title": "Application of SVM combined with mackov chain for inventory prediction in supply chain",
        "abstract": "The aim of this paper is to predict the inventory of the relevant upstream enterprises in supply chain. The support vector machine, a novel artificial intelligence-based method developed from statistical learning theory, is adopted herein to establish a short-term stage forecasting model. However, take the fact into account that demand signal is affected by variant random factors and behaves big uncertainty, the predicted accuracy of SVM is not approving when the data show great randomness. It is obligatory that we present Markov chain to improve the predicted accuracy of SVM. This combined model takes advantage of the high predictable power of SVM model and at the same time take advantage of the prediction power of Markov chain modeling on the discrete states based on the SVM modeling residual sequence. Then we use the statistical data of the output of the gasoline of China from Feb-06 to Dec-07 for a validation of the effectiveness of the above model. © 2008 IEEE.",
        "keywords": [
            "markov chain",
            "predict",
            "supply chain",
            "svm",
            "support vector machines",
            "supply chains",
            "support vector machine",
            "mathematical model",
            "accuracy",
            "predictive models",
            "forecasting",
            "artificial intelligent",
            "markov processes",
            "markov chain model"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Wenjin Zhu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            }
        ],
        "venue": "2008 International Conference on Wireless Communications, Networking and Mobile Computing, WiCOM 2008",
        "year": 2008
    },
    "nkdNvVEB": {
        "id": "nkdNvVEB",
        "title": "Medium-term wind speeds forecasting utilizing hybrid models for three different sites in Xinjiang, China",
        "abstract": "",
        "keywords": [
            "outlier detection",
            "support vector regression"
        ],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "shanshan qin",
                "org": ""
            },
            {
                "name": "qingping zhou",
                "org": ""
            },
            {
                "name": "haiyan jiang",
                "org": ""
            }
        ],
        "venue": "Renewable Energy",
        "year": 2015
    },
    "NsjBtjnM": {
        "id": "NsjBtjnM",
        "title": "A robust combination approach for short-term wind speed forecasting and analysis – Combination of the ARIMA (Autoregressive Integrated Moving Average), ELM (Extreme Learning Machine), SVM (Support Vector Machine) and LSSVM (Least Square SVM) forecasts using a GPR (Gaussian Process Regression) model",
        "abstract": "",
        "keywords": [
            "support vector machine",
            "gaussian process regression"
        ],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "jianming hu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "MU1jNf7t": {
        "id": "MU1jNf7t",
        "title": "Electricity Demand Forecasting Based on Feedforward Neural Network Training by a Novel Hybrid Evolutionary Algorithm",
        "abstract": "Electricity demand forecasting is an important index to make power development plan and dispatch the loading of generating units in order to meet system demand. In order to improve the accuracy of the forecasting, we apply the feedforward neural network for electricity demand forecasting. Inspired by the idea of artificial fish swarm algorithm, in this paper we proposed one hybrid evolutionary algorithm which based on PSO and AFSA methods through crossing over the PSO and AFSA algorithms to train the feedforward neural network. This proposed method has been applied in a real electricity load forecasting, the results show that the proposed approach has a better generalization performance and is also more accurate and effective than the feedforward neural network trained by particle swarm optimization.",
        "keywords": [
            "feedforward neural network training",
            "particle swarm optimization (pso)",
            "artificial fish swarm algorithm (afsa)",
            "multi-layer feedforward neural network",
            "evolutionary computation",
            "novel hybrid evolutionary algorithm",
            "hybrid evolutionary algorithm",
            "particle swarm optimisation",
            "real electricity load forecasting",
            "electricity load forecasting",
            "feedforward neural nets",
            "afsa algorithm",
            "electricity demand forecasting",
            "feedforward neural network",
            "power engineering computing",
            "artificial fish",
            "load forecasting",
            "artificial fish swarm algorithm",
            "afsa method",
            "system demand",
            "swarm algorithm",
            "particle swarm optimization",
            "artificial neural networks",
            "demand forecasting",
            "prediction algorithms",
            "forecasting",
            "electricity",
            "feedforward neural networks",
            "indexation"
        ],
        "authors": [
            {
                "name": "Wenyu Zhang",
                "org": ""
            },
            {
                "name": "Yuanyuan Wang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            }
        ],
        "venue": "Computer Engineering and Technology, 2009. ICCET '09. International Conference",
        "year": 2009
    },
    "V2PEX5il": {
        "id": "V2PEX5il",
        "title": "Short-term electricity prices forecasting based on support vector regression and Auto-regressive integrated moving average modeling",
        "abstract": "",
        "keywords": [
            "arima",
            "artificial neural networks",
            "competitive market",
            "price forecasting",
            "support vector regression",
            "artificial neural network",
            "mean absolute percentage error",
            "root mean square error",
            "time series",
            "mathematical model",
            "neural network",
            "arima model",
            "linear model",
            "loss function"
        ],
        "authors": [
            {
                "name": "Jinxing Che",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2010
    },
    "8utOwrpf": {
        "id": "8utOwrpf",
        "title": "Detecting and Disposing Abnormal Signal Outliers with Masking Effect by Using Data Accumulated Generating Operation",
        "abstract": "In this paper, we study a signal processing problem which concentrates on outlier detection and data mining in order to rediscover some useful information. Moreover, the great difficulty of the subject is caused by both the external environment and the internal mechanism. In the external, owing to limit of impersonal condition, such as, realistic disturbance from noise signal can not avoid. In the internal, the masking effect appears in outlying observation so as to produce some unreasonable results by data analysis. Therefore, based not only on the requirement of external quality assurance schemes, but also on internal quality control where screening for outliers should probably be part of the procedure for our main goal. As a consequence, we have applied data accumulated generating operation and sample median test for solving the conundrum.",
        "keywords": [
            "impersonal condition",
            "internal quality control",
            "noise signal",
            "external quality assurance scheme",
            "data analysis",
            "disposing abnormal signal outliers",
            "external environment",
            "accumulated generating operation(ago)",
            "great difficulty",
            "signal processing problem",
            "internal mechanism",
            "outlying observation",
            "inverse accumulated generating operation (iago)",
            "data mining",
            "data accumulated generating operation",
            "masking effect",
            "outlier detection",
            "signal generators",
            "laser radar",
            "quality assurance",
            "quality control",
            "signal analysis",
            "testing",
            "noise",
            "software engineering",
            "mathematics",
            "wavelet analysis",
            "statistics",
            "biochemistry",
            "robustness",
            "signal processing",
            "distribution functions",
            "earth"
        ],
        "authors": [
            {
                "name": "Jian-zhou Wang",
                "org": ""
            },
            {
                "name": "Jian-ning Wen",
                "org": ""
            },
            {
                "name": "Dong-huai Sun",
                "org": ""
            },
            {
                "name": "Hai-yan Lu",
                "org": ""
            }
        ],
        "venue": "Image and Signal Processing, 2008. CISP '08. Congress",
        "year": 2008
    },
    "Ynj4hzAO": {
        "id": "Ynj4hzAO",
        "title": "Chaotic Time Series Forecasting Base on Fuzzy Adaptive PSO for Feedforward Neural Network Training",
        "abstract": "Short-term electricity demand forecasting for the next hour to several days out is one of the most important tools by which an electric utility plans and dispatches the loading of generating units in order to meet system demand. But there exists chaos in electricity systems to a great extent. Complicated electricity systems are nonlinear systems and the forecasting is very complex in nature and quite hard to solve by conventional algorithm. The inaccuracy or large error in the forecast simply means that load matching is not optimized and consequently the generation and transmission systems are not being operated in an efficient manner. In this paper, feedforward neural network trained by fuzzy adaptive PSO algorithm is proposed for chaotic load time series global prediction. The results which are compared with feedforward neural network trained by Levenberg-Marquardt back-propagation (LMBP) algorithm show much more satisfactory performance, converges quickly towards the optimal position, convergent accuracy and can avoid overfitting in some extent.",
        "keywords": [
            "levenberg-marquardt back-propagation algorithm",
            "feedforward neural network training",
            "short-term electricity demand forecasting",
            "particle swarm optimization (pso)",
            "fuzzy system",
            "complicated electricity systems",
            "fuzzy set theory",
            "fuzzy adaptive pso",
            "chaotic load time series",
            "load matching",
            "fuzzy adaptive pso algorithm",
            "chaotic time series forecasting",
            "particle swarm optimisation",
            "electricity system",
            "complicated electricity system",
            "nonlinear systems",
            "backpropagation",
            "feedforward neural nets",
            "feedforward neural network",
            "power engineering computing",
            "great extent",
            "chaotic time series",
            "load forecasting",
            "conventional algorithm",
            "system demand",
            "time series",
            "particle swarm optimization",
            "nonlinear system",
            "feedforward neural networks",
            "fuzzy systems",
            "levenberg marquardt",
            "algorithm design and analysis",
            "demand forecasting",
            "time series analysis",
            "prediction algorithms",
            "back propagation",
            "artificial neural networks"
        ],
        "authors": [
            {
                "name": "Wenyu Zhang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Jinxing Che",
                "org": ""
            }
        ],
        "venue": "ICYCS",
        "year": 2008
    },
    "9cpsURsS": {
        "id": "9cpsURsS",
        "title": "A Novel System for Wind Speed Forecasting Based on Multi-Objective Optimization and Echo State Network",
        "abstract": "Given the rapid development and wide application of wind energy, reliable and stable wind speed forecasting is of great significance in keeping the stability and security of wind power systems. However, accurate wind speed forecasting remains a great challenge due to its inherent randomness and intermittency. Most previous researches merely devote to improving the forecasting accuracy or stability while ignoring the equal significance of improving the two aspects in application. Therefore, this paper proposes a novel hybrid forecasting system containing the modules of a modified data preprocessing, multi-objective optimization, forecasting, and evaluation to achieve the wind speed forecasting with high precision and stability. The modified data preprocessing method can obtain a smoother input by decomposing and reconstructing the original wind speed series in the module of data preprocessing. Further, echo state network optimized by a multi-objective optimization algorithm is developed as a predictor in the forecasting module. Finally, eight datasets with different features are used to validate the performance of the proposed system using the evaluation module. The mean absolute percentage errors of the proposed system are 3.1490%, 3.0051%, 3.0618%, and 2.6180% in spring, summer, autumn, and winter, respectively. Moreover, the interval prediction is complemented to quantitatively characterize the uncertainty as developing intervals, and the mean average width is below 0.2 at the 95% confidence level. The results demonstrate the proposed forecasting system outperforms other comparative models considered from the forecasting accuracy and stability, which has great potential in the application of wind power systems.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Chunying Wu",
                "org": ""
            },
            {
                "name": "Tong Niu",
                "org": ""
            }
        ],
        "venue": "Sustainability",
        "year": 2019
    },
    "CieixoZp": {
        "id": "CieixoZp",
        "title": "A hybrid technique for short-term wind speed prediction",
        "abstract": "",
        "keywords": [
            "wind speed"
        ],
        "authors": [
            {
                "name": "jianming hu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "kailiang ma",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "u74HiKtd": {
        "id": "u74HiKtd",
        "title": "Reliability Analysis and Overload Capability Assessment of Oil-Immersed Power Transformers",
        "abstract": "",
        "keywords": [
            "power transformers"
        ],
        "authors": [
            {
                "name": "chen wang",
                "org": ""
            },
            {
                "name": "jie wu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "weigang zhao",
                "org": ""
            }
        ],
        "venue": "Energies",
        "year": 2016
    },
    "Ci9VR65D": {
        "id": "Ci9VR65D",
        "title": "Performance analysis of four modified approaches for wind speed forecasting",
        "abstract": "Providing accurate wind speed prediction algorithms has become increasingly significant because of the important technological and economic impacts of wind speed on wind power generation. In this study, two combined strategies for wind speed forecasting are proposed and followed. Four approaches derived from these strategies are employed. The first two approaches employ Particle Swarm Optimization (PSO) to optimize the parameters in the first-order and second-order adaptive coefficient (FAC and SAC) methods. The remaining two approaches employ the decomposition of wind speed data into seasonal and trend components. The seasonal component is represented by the seasonal exponential adjustment, and the trend component is predicted by the hybrid models of PSO and FAC or SAC. By employing these four approaches, the daily mean wind speed is forecasted for four observation sites in Gansu, China. Multiple evaluation methods are used to assess forecasting quality: the mean square error, the mean absolute percentage error and the relative error. It is found that all four approaches better predict wind speed than the original FAC and SAC models. © 2012 Elsevier Ltd.",
        "keywords": [
            "data decomposition",
            "evaluation criterion",
            "parameter selection",
            "wind speed forecasting"
        ],
        "authors": [
            {
                "name": "Wenyu Zhang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jie Wu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Weigang Zhao",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Lin Shen",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Applied Energy",
        "year": 2012
    },
    "UxmakgGC": {
        "id": "UxmakgGC",
        "title": "A study on the characteristics, predictions and policies of China’s eight main power grids",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "yao dong",
                "org": ""
            },
            {
                "name": "he jiang",
                "org": ""
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2014
    },
    "d9FnWLKb": {
        "id": "d9FnWLKb",
        "title": "Prediction of ozone concentration using back propagation neural network with a novel hybrid training algorithm",
        "abstract": "This paper proposed a new hybrid forecasting model for the prediction of ozone concentrations in semi-arid area. It is based on chaotic, particle swarm optimization algorithm (CPSO) and back propagation (BP) neural network, called CPSO-BP neural network. The results show that the proposed hybrid model is superior to both the BP neural network and the regression model being tested. The hybrid model achieves 18.7% in root mean square error reduction compared to BP model, and 8.1% reduction compared to stepwise regression model. It could be a promising model on forecasting ozone concentration in semi-arid area.",
        "keywords": [
            "bp neural network",
            "chaotic particle swarm optimization",
            "chaos",
            "ozone concentration forecasting prediction",
            "root mean square error reduction",
            "stepwise regression model",
            "regression analysis",
            "particle swarm optimisation",
            "regression model",
            "cpso-bp neural network",
            "backpropagation",
            "environmental science computing",
            "particle swarm optimization algorithm",
            "ozone",
            "oxygen",
            "back propagation neural network",
            "chaotic algorithm",
            "hybrid forecasting model",
            "neural nets",
            "hybrid training algorithm",
            "atmospheric modeling",
            "neural network",
            "particle swarm optimization",
            "data models",
            "artificial neural networks",
            "root mean square error",
            "stepwise regression",
            "back propagation",
            "predictive models",
            "forecasting"
        ],
        "authors": [
            {
                "name": "Wen-Yu Zhang",
                "org": ""
            },
            {
                "name": "Xin Liu",
                "org": ""
            },
            {
                "name": "Zhen-Hai Guo",
                "org": ""
            },
            {
                "name": "Jian-Zhou Wang",
                "org": ""
            }
        ],
        "venue": "ICNC",
        "year": 2010
    },
    "5p9nLaau": {
        "id": "5p9nLaau",
        "title": "A novel application of artificial neural network for wind speed estimation",
        "abstract": "",
        "keywords": [
            "data pre processing",
            "artificial neural network"
        ],
        "authors": [
            {
                "name": "da fang",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            }
        ],
        "venue": "International Journal of Sustainable Energy",
        "year": 2015
    },
    "qBxOxAMU": {
        "id": "qBxOxAMU",
        "title": "A novel approach for electricity demand forecasting",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "caihong li",
                "org": ""
            },
            {
                "name": "senhui mu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "yi yang",
                "org": ""
            },
            {
                "name": "lian li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "ndynkS0L": {
        "id": "ndynkS0L",
        "title": "A novel hybrid evolutionary algorithm based on PSO and AFSA for feedforward neural network training",
        "abstract": "In recent years, the multilayer feedforward neural network (FNN) has been received considerable attention and have been extensively used in many fields. Levenberg-Marquardt back-propagation (LMBP) algorithm as an FNN training method has some limitations associated with overfitting, local optimum problems and slow convergence rate. In order to overcome the limitations, some people proposed particle swarm optimization (PSO) as an evolutionary algorithm to train the FNN. But PSO has disadvantages such as low precision, slow convergence in the later stage of the evolution, and parameter selection problems. In this paper, a novel hybrid evolutionary algorithm based on AFSA and PSO, also referred to as AFSA-PSO-parallel-hybrid evolutionary (APPHE) algorithm, has been used in FNN training. Compared to FNN trained by LMBP algorithm, FNN training by the novel hybrid evolutionary algorithm show satisfactory performance, converges quickly towards the optimal position, convergent accuracy, high stability and can avoid overfitting in some extent. FNN training by the novel method has been testified by using in Iris data classification and the rusults are much more accurate and stable than by Levenberg-Marquardt back-propagation algorithm. © 2008 IEEE.",
        "keywords": [
            "artificial fish swarm algorithm (afsa)",
            "feedforward neural network (fnn)",
            "particle swarm optimization (pso) algorithm",
            "back propagation",
            "classification algorithms",
            "artificial neural networks",
            "convergence rate",
            "iris",
            "feedforward neural networks",
            "backpropagation",
            "evolutionary algorithm",
            "particle swarm optimization",
            "feedforward neural network",
            "levenberg marquardt",
            "evolutionary computation"
        ],
        "authors": [
            {
                "name": "Xuejun Chen",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhao Liang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "2008 International Conference on Wireless Communications, Networking and Mobile Computing, WiCOM 2008",
        "year": 2008
    },
    "zD77aPeq": {
        "id": "zD77aPeq",
        "title": "Prediction study and application of wind power development based on filtering error threshold",
        "abstract": "",
        "keywords": [
            "kalman filter"
        ],
        "authors": [
            {
                "name": "ziqi zhang",
                "org": "lanzhou university"
            },
            {
                "name": "rui zhang",
                "org": ""
            },
            {
                "name": "da fang",
                "org": "southeast university"
            },
            {
                "name": "jianzhou wang",
                "org": "lanzhou university"
            }
        ],
        "venue": "Environmental Progress",
        "year": 2015
    },
    "kTUgCK86": {
        "id": "kTUgCK86",
        "title": "Intelligent optimization models based on hard-ridge penalty and RBF for forecasting global solar radiation",
        "abstract": "",
        "keywords": [
            "differential evolution"
        ],
        "authors": [
            {
                "name": "he jiang",
                "org": ""
            },
            {
                "name": "yao dong",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "yuqin li",
                "org": ""
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2015
    },
    "rr7wAh6z": {
        "id": "rr7wAh6z",
        "title": "The Forecasting Procedure for Long-Term Wind Speed in the Zhangye Area",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhenhai guo",
                "org": ""
            },
            {
                "name": "yao dong",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "haiyan lu",
                "org": ""
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2010
    },
    "53IClDBq": {
        "id": "53IClDBq",
        "title": "Research and Application of a Novel Combined Model Based on Multiobjective Optimization for Multistep-Ahead Electric Load Forecasting",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yechi Zhang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Haiyan Lu",
                "org": ""
            }
        ],
        "venue": "Energies",
        "year": 2019
    },
    "eP4g1Uvj": {
        "id": "eP4g1Uvj",
        "title": "Stock index forecasting based on a hybrid model",
        "abstract": "Forecasting the stock market price index is a challenging task. The exponential smoothing model (ESM), autoregressive integrated moving average model (ARIMA), and the back propagation neural network (BPNN) can be used to make forecasts based on time series. In this paper, a hybrid approach combining ESM, ARIMA, and BPNN is proposed to be the most advantageous of all three models. The weight of the proposed hybrid model (PHM) is determined by genetic algorithm (GA). The closing of the Shenzhen Integrated Index (SZII) and opening of the Dow Jones Industrial Average Index (DJIAI) are used as illustrative examples to evaluate the performances of the PHM. Numerical results show that the proposed model outperforms all traditional models, including ESM, ARIMA, BPNN, the equal weight hybrid model (EWH), and the random walk model (RWM). © 2011 Elsevier Ltd.",
        "keywords": [
            "arima",
            "bpnn",
            "exponential smoothing",
            "forecasting",
            "genetic algorithm",
            "hybrid model",
            "stock price",
            "price index",
            "time series",
            "moving average",
            "indexation",
            "random walk"
        ],
        "authors": [
            {
                "name": "Jujie Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Zhe George Zhang",
                "org": "Western Washington University(Western Washington University),Bellingham,United States"
            },
            {
                "name": "ShuPo Guo",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Omega",
        "year": 2012
    },
    "U9PSs265": {
        "id": "U9PSs265",
        "title": "A trend fixed on firstly and seasonal adjustment model combined with the ε-SVR for short-term forecasting of electricity demand",
        "abstract": "Short-term electricity demand forecasting has always been an essential instrument in power system planning and operation by which an electric utility plans and dispatches loading so as to meet system demand. The accuracy of the dispatching system, derived from the accuracy of demand forecasting and the forecasting algorithm used, will determines the economic of the power system operation as well as the stability of the whole society. This paper presents a combined ε -SVR model considering seasonal proportions based on development tendencies from history data. We use one-order moving averages to produce a comparatively smooth data series, taking the averaging period as the interval that can effectively eliminate the seasonal variation. We used the smoothed data series as the training set input for the ε -SVR model and obtained the corresponding forecasting value. Afterward, we accounted for the previously removed seasonal variation. As a case, we forecast northeast electricity demand of China using the new method. We demonstrated that this simple procedure has very satisfactory overall performance by an analysis of variance with relative verification and validation. Significant reductions in forecast errors were achieved.",
        "keywords": [
            "ε -SVR",
            "Trend fixed on firstly",
            "Seasonal adjustment"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Wenjin Zhu",
                "org": ""
            },
            {
                "name": "Wenyu Zhang",
                "org": "College of Atmospheric Sciences; Lanzhou University; Lanzhou 730000, China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Key Laboratory of Western Chinas Environmental Systems (Ministry of Education) College of Earth and Environment Sciences, Lanzhou University, Lanzhou 730000, China"
            }
        ],
        "venue": "Energy Policy",
        "year": 2009
    },
    "I7K9uVXA": {
        "id": "I7K9uVXA",
        "title": "Short-term wind speed prediction using empirical wavelet transform and Gaussian process regression",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianming hu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "0a6anSc1": {
        "id": "0a6anSc1",
        "title": "The Number of Chinese International Airlines Forecasting Based on Grey Model Using Fuzzy Adaptive PSO Algorithm",
        "abstract": "Shooting three same surfaces of revolution(SOR) with the camera results in a special image. Through studying the geometric of SOR in this image, we show that such image can provide sufficient information for camera calibration. Experiment proves that ...",
        "keywords": [
            "fuzzy adaptive pso algorithm",
            "camera result",
            "camera calibration",
            "grey model",
            "sufficient information",
            "special image",
            "chinese international airlines forecasting",
            "convergence",
            "technology forecasting",
            "aviation industry",
            "avionics",
            "fuzzy system",
            "information science",
            "particle swarm optimization",
            "travel industry",
            "economic forecasting",
            "predictive models",
            "mathematical model",
            "algorithm design and analysis",
            "aerospace industry",
            "computational intelligence",
            "fuzzy systems",
            "information technology"
        ],
        "authors": [
            {
                "name": "Dongshan Gong",
                "org": ""
            },
            {
                "name": "Yuanyuan Wang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            }
        ],
        "venue": "ISISE '08 Proceedings of the 2008 International Symposium on Information Science and Engieering - Volume 01",
        "year": 2008
    },
    "n68Sxb5N": {
        "id": "n68Sxb5N",
        "title": "Short-term load forecasting using a kernel-based support vector regression combination model",
        "abstract": "",
        "keywords": [
            "support vector regression",
            "kernel"
        ],
        "authors": [
            {
                "name": "jinxing che",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            }
        ],
        "venue": "Applied Energy",
        "year": 2014
    },
    "vuUpneJ0": {
        "id": "vuUpneJ0",
        "title": "Decision Support in Cancer Base on Fuzzy Adaptive PSO for Feedforward Neural Network Training",
        "abstract": "In the last decade, the use of artificial neural networks (ANN) has become widely accepted in medical applications for accuracy for predictive inference, with potential to support and flexible non-linear modelling of large data sets. Feedforward neural network (FNN) is a kind of artificial neural networks, which has a better structure and been widely used. But there are still many drawbacks if we simply use feedforward neural network, such as slow training rate, easy to trap into local minimum point, and bad ability on global search. In this paper, feedforward neural network trained by fuzzy adaptive particle swarm optimization (FPSO) algorithm is proposed for breast cancer diagnosis. The results which are compared with FNN trained by PSO algorithm show much more accurate and stable, converges quickly towards the optimal position and can avoid overfitting in some extent. In the computer-aided decision systems, the accurate and stable computer algorithms are very important to help a physician in diagnosing a patient.",
        "keywords": [
            "feedforward neural network training",
            "fuzzy system",
            "fuzzy set theory",
            "fuzzy adaptive pso",
            "feedforward neural network (fnn)",
            "server key management protocol",
            "predictive inference",
            "wimax security",
            "decision support",
            "inference mechanisms",
            "particle swarm optimization (pso) algorithm",
            "learning (artificial intelligence)",
            "particle swarm optimisation",
            "wireless network",
            "breast cancer diagnosis",
            "artificial neural networks",
            "fuzzy adaptive particle swarm optimization algorithm",
            "feedforward neural nets",
            "authenticated client",
            "knowledge engineering",
            "computer-aided decision systems",
            "cancer",
            "decision support systems",
            "security sub-layer",
            "cancer base",
            "medical diagnostic computing",
            "access control",
            "feedforward neural networks",
            "artificial neural network",
            "feedforward neural network",
            "learning artificial intelligence",
            "breast cancer"
        ],
        "authors": [
            {
                "name": "Liman Zhang",
                "org": ""
            },
            {
                "name": "Haiming Wang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            }
        ],
        "venue": "ISCSCT (1)",
        "year": 2008
    },
    "PDeZUtui": {
        "id": "PDeZUtui",
        "title": "Analysis and forecasting of the particulate matter (PM) concentration levels over four major cities of China using hybrid models",
        "abstract": "",
        "keywords": [
            "cuckoo search"
        ],
        "authors": [
            {
                "name": "shanshan qin",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "beibei sun",
                "org": ""
            }
        ],
        "venue": "Atmospheric Environment",
        "year": 2014
    },
    "WJU3vVW6": {
        "id": "WJU3vVW6",
        "title": "A novel hybrid approach for wind speed prediction.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jujie Wang",
                "org": ""
            },
            {
                "name": "Wenyu Zhang",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Tingting Han",
                "org": ""
            },
            {
                "name": "Lingbin Kong",
                "org": ""
            }
        ],
        "venue": "Inf. Sci.",
        "year": 2014
    },
    "pfGSwaih": {
        "id": "pfGSwaih",
        "title": "Ontology-based assembly design and information sharing for supply chain information",
        "abstract": "Nowadays, supply chain information is increasingly used by many entities around the world. Then, the need of sharing information from different sources is an obvious consequence from such proliferation of systems. Unfortunately, integrating supply chain information is not a trivial issue, because data and knowledge exchange among users of supply chain information systems presents many challenges. We must deal with the heterogeneity problem, which increase complexity of integration approaches. This paper discusses issues related to the use of ontologies in the development of supply chain information systems and proposes the creation of software components from diverse ontologies as a way to share data and supply chain information. Copyright© (2008) by Computers & Industrial Engineering.",
        "keywords": [
            "Heterogeneity problem",
            "Information sharing and reusing",
            "Ontology",
            "Supply chain"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Huiting Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Donghuai Sun",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            }
        ],
        "venue": "38th International Conference on Computers and Industrial Engineering 2008",
        "year": 2008
    },
    "micVfwHJ": {
        "id": "micVfwHJ",
        "title": "Estimation methods review and analysis of offshore extreme wind speeds and wind energy resources",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "shanshan qin",
                "org": ""
            },
            {
                "name": "shiqiang jin",
                "org": ""
            },
            {
                "name": "jie wu",
                "org": ""
            }
        ],
        "venue": "Renewable & Sustainable Energy Reviews",
        "year": 2015
    },
    "J3FiBvku": {
        "id": "J3FiBvku",
        "title": "Short-Term Wind Speed Forecasting Using Support Vector Regression Optimized by Cuckoo Optimization Algorithm",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "qingping zhou",
                "org": ""
            },
            {
                "name": "haiyan jiang",
                "org": ""
            },
            {
                "name": "ru hou",
                "org": ""
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2015
    },
    "VvAzNhZX": {
        "id": "VvAzNhZX",
        "title": "An improved new approach for electric capacity forecasting based on historical data of GDP",
        "abstract": "Prediction is important for the electricity capacity management. Accurate prediction can help the policymaker make correct decision and promote the decision making quality. For improving an accuracy of prediction, in this paper, we adopt the theory of Grey prediction to develop a new forecasting approach that integrates historical data of the gross domestic products (GDP) into an electric capacity forecasting. We adopted Grey prediction as a forecasting means because of its fast calculation with as few as four data inputs needed. As a result, our study considered that Wu and Chen proposed a modeling method of the improved grey relational analysis and main shows that the general Grey model, GM (1, 1), which is an especial case, is adequate to handle an electrical power system. In this study, the prediction is improved significantly by applying the transformed Grey model and the concept of average system slope. The adaptive value of a in the Grey differential equation is obtained quickly with the average system slope technique. In such a way, the wastage of electric consumption can be avoided. That is, it is another achievement of virtual electric power plant. ©2008 IEEE.",
        "keywords": [
            "electric capacity forecasting",
            "grey prediction",
            "grey relational analysis",
            "gross domestic products (gdp)",
            "predictive models",
            "energy management",
            "gdp",
            "economic forecasting",
            "economic indicators",
            "artificial intelligence",
            "accuracy",
            "technology forecasting",
            "differential equations"
        ],
        "authors": [
            {
                "name": "Jianning Wen",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Haiyan Lu",
                "org": "University of Technology Sydney(University of Technology,University of Technology Sydney),Sydney,Australia"
            }
        ],
        "venue": "2008 3rd IEEE Conference on Industrial Electronics and Applications, ICIEA 2008",
        "year": 2008
    },
    "GrIQO8nl": {
        "id": "GrIQO8nl",
        "title": "Application of residual modification approach in seasonal ARIMA for electricity demand forecasting: A case study of China",
        "abstract": "Electricity demand forecasting could prove to be a useful policy tool for decision-makers; thus, accurate forecasting of electricity demand is valuable in allowing both power generators and consumers to make their plans. Although a seasonal ARIMA model is widely used in electricity demand analysis and is a high-precision approach for seasonal data forecasting, errors are unavoidable in the forecasting process. Consequently, a significant research goal is to further improve forecasting precision. To help people in the electricity sectors make more sensible decisions, this study proposes residual modification models to improve the precision of seasonal ARIMA for electricity demand forecasting. In this study, PSO optimal Fourier method, seasonal ARIMA model and combined models of PSO optimal Fourier method with seasonal ARIMA are applied in the Northwest electricity grid of China to correct the forecasting results of seasonal ARIMA. The modification models forecasting of the electricity demand appears to be more workable than that of the single seasonal ARIMA. The results indicate that the prediction accuracy of the three residual modification models is higher than the single seasonal ARIMA model and that the combined model is the most satisfactory of the three models. © 2012 Elsevier Ltd.",
        "keywords": [
            "electricity demand",
            "residual modification model",
            "seasonal arima"
        ],
        "authors": [
            {
                "name": "Yuanyuan Wang",
                "org": "Ningbo University of Technology(Ningbo University of Technology),Ningbo,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Ge Zhao",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Energy Policy",
        "year": 2012
    },
    "1uikmCXf": {
        "id": "1uikmCXf",
        "title": "Interval forecasts of a novelty hybrid model for wind speeds",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shanshan qin",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "yiliao song",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "t1aLUSCb": {
        "id": "t1aLUSCb",
        "title": "A novel hybrid approach for wind speed prediction",
        "abstract": "",
        "keywords": [
            "neural network",
            "seasonal adjustment",
            "exponential smoothing"
        ],
        "authors": [
            {
                "name": "wenyu zhang",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "tingting han",
                "org": ""
            },
            {
                "name": "lingbin kong",
                "org": ""
            }
        ],
        "venue": "Information Sciences",
        "year": 2014
    },
    "kSYx6XTP": {
        "id": "kSYx6XTP",
        "title": "A novel model: Dynamic choice artificial neural network (DCANN) for an electricity price forecasting system.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Feng Liu",
                "org": ""
            },
            {
                "name": "Yiliao Song",
                "org": ""
            },
            {
                "name": "Jing Zhao",
                "org": ""
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2016
    },
    "8qwWlCVJ": {
        "id": "8qwWlCVJ",
        "title": "A combined model based on data pre-analysis and weight coefficients optimization for electrical load forecasting",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "liye xiao",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "ru hou",
                "org": ""
            },
            {
                "name": "jie wu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "ax6TbPDE": {
        "id": "ax6TbPDE",
        "title": "A novel sub-models selection algorithm based on max-relevance and min-redundancy neighborhood mutual information",
        "abstract": "Abstract   Combination models are regarded as a popular approach to improve forecasting accuracy. Determining how to select optimal sub-models from all possible candidate models is considered to be a challenge in combination models because of the high computational overhead. However, there is fewer studies on sub-models selection for combination approaches. To this end, this study proposes a novel sub-models selection algorithm named neighborhood mutual information (NMI) theory-based maximizing linear relevance and minimizing linear redundancy (NMI-MRMR) to select the optimal sub-models set. Cuckoo search (CS) is used to find the optimal parameter of a neighborhood for the proposed algorithm by avoiding the evaluation of all possible parameters. Three cases are used to validate the performance of the proposed approach. The experimental forecasting results demonstrate that the combination of the individual models selected by the NMI-MRMR based CS algorithm significantly outperforms the combination of the individual models selected by traditional approaches. Furthermore, a comparison with two other artificial intelligence algorithms and a traversal algorithm indicate that the CS algorithm is more suitable for choosing the optimal parameter for the proposed algorithm. The proposed approach not only overcomes the shortcomings of combining all individual models but is also able to select the optimal sub-models set.",
        "keywords": "",
        "authors": [
            {
                "name": "Ling Xiao",
                "org": ""
            },
            {
                "name": "Chen Wang",
                "org": ""
            },
            {
                "name": "Yunxuan Dong",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            }
        ],
        "venue": "Information Sciences",
        "year": 2019
    },
    "Tl1XsKlj": {
        "id": "Tl1XsKlj",
        "title": "ARMA Model identification using Particle Swarm Optimization Algorithm",
        "abstract": "In this paper, a new approach to ARMA model identification using evolutionary particle swarm optimization (PSO) algorithm has been proposed. ARMA is a popular method to analyze stationary univariate time series data. Stationarity checking, model identification, model estimation and model checking are usually four main stages to build an ARMA model and model identification is the most important stage in building ARMA models. However there is no method suitable for ARMA model that can overcome the problem of local optima, which is suitable for any ARMA model. The effectiveness of PSO Algorithm which is used to choose the parameters of ARMA Model automatically is tested for ARMA (2,2) model example. The identification of model ARMA(2,2): xt +0.1xt-1-0.2xt-2 = at+0.2at-1-0.5at-2. The simulation shows that the PSO-based model identification method can present better solutions than the MINIC model identification method.",
        "keywords": [
            "particle swarm optimization (pso)",
            "arma model identification",
            "evolutionary computation",
            "univariate time series",
            "model identification",
            "model checking",
            "arma model",
            "evolutionary particle swarm optimization",
            "particle swarm optimisation",
            "autoregressive moving average processes",
            "popular method",
            "model estimation",
            "model example",
            "minic model identification method",
            "particle swarm optimization algorithm",
            "stationarity checking",
            "minic algorithm",
            "pso-based model identification method",
            "time series",
            "model arma",
            "time series analysis",
            "computational modeling",
            "mathematical model",
            "estimation",
            "data models",
            "time series data"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Jinzhao Liang",
                "org": ""
            },
            {
                "name": "Jinxing Che",
                "org": ""
            },
            {
                "name": "Donghuai Sun",
                "org": ""
            }
        ],
        "venue": "Singapore",
        "year": 2008
    },
    "kLRlcaoD": {
        "id": "kLRlcaoD",
        "title": "The Combination Forecasting of Electricity Price Based on Price Spikes Processing: A Case Study in South Australia",
        "abstract": "Electricity price forecasting holds very important position in the electricity market. Inaccurate price forecasting may cause energy waste and management chaos in the electricity market. However, electricity price forecasting has always been regarded as one of the largest challenges in the electricity market because it shows high volatility, which makes electricity price forecasting difficult. This paper proposes the use of artificial intelligence optimization combination forecasting models based on preprocessing data, called \"chaos particles optimization (CPSO) weight-determined combination models.\" These models allow for the weight of the combined model to take values of [-1, 1]. In the proposed models, the density-based spatial clustering of applications with noise (DBSCAN) algorithm is used to identify outliers, and the outliers are replaced by a new data-produced linear interpolation function. The proposed CPSO weight-determined combination models are then used to forecast the projected future electricity price. In this case study, the electricity price data of South Australia are simulated. The results indicate that, while the weight of the combined model takes values of [-1, 1], the proposed combination model can always provide adaptive, reliable, and comparatively accurate forecast results in comparison to traditional combination models.",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": "Dongbei Univ Finance & Econ, Sch Stat, Dalian 116025, Peoples R China"
            },
            {
                "name": "ling xiao",
                "org": "Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China"
            },
            {
                "name": "jun shi",
                "org": "Lanzhou Univ, Sch Informat Sci & Engn, Lanzhou 730000, Peoples R China"
            }
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2014
    },
    "VfUQp2mE": {
        "id": "VfUQp2mE",
        "title": "Forecasting wind speed using empirical mode decomposition and Elman neural network",
        "abstract": "Because of the chaotic nature and intrinsic complexity of wind speed, it is difficult to describe the moving tendency of wind speed and accurately forecast it. In our study, a novel EMD-ENN approach, a hybrid of empirical mode decomposition (EMD) and Elman neural network (ENN), is proposed to forecast wind speed. First, the original wind speed datasets are decomposed into a collection of intrinsic mode functions (IMFs) and a residue by EMD, yielding relatively stationary sub-series that can be readily modeled by neural networks. Second, both IMF components and residue are applied to establish the corresponding ENN models. Then, each sub-series is predicted using the corresponding ENN. Finally, the prediction values of the original wind speed datasets are calculated by the sum of the forecasting values of every sub-series. Moreover, in the ENN modeling process, the neuron number of the input layer is determined by a partial autocorrelation function. Four prediction cases of wind speed are used to test the performance of the proposed hybrid approach. Compared with the persistent model, back-propagation neural network, and ENN, the simulation results show that the proposed EMD-ENN model consistently has the minimum statistical error of the mean absolute error, mean square error, and mean absolute percentage error. Thus, it is concluded that the proposed approach is suitable for wind speed prediction.",
        "keywords": [
            "emd",
            "elman neural network",
            "hybrid model",
            "pacf",
            "wind speed prediction"
        ],
        "authors": [
            {
                "name": "Jujie Wang",
                "org": ""
            },
            {
                "name": "Wenyu Zhang",
                "org": ""
            },
            {
                "name": "Yaning Li",
                "org": ""
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Zhangli Dang",
                "org": ""
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2014
    },
    "Y8BqDu24": {
        "id": "Y8BqDu24",
        "title": "Short-term electricity price forecast based on the improved hybrid model",
        "abstract": "Half-hourly electricity price in power system are volatile, electricity price forecast is significant information which can help market managers and participants involved in electricity market to prepare their corresponding bidding strategies to maximize their benefits and utilities. However, the fluctuation of electricity price depends on the common effect of many factors and there is a very complicated random in its evolution process. Therefore, it is difficult to forecast half-hourly prices with traditional only one model for different behaviors of half-hourly prices. This paper proposes the improved forecasting model that detaches high volatility and daily seasonality for electricity price of New South Wales in Australia based on Empirical Mode Decomposition, Seasonal Adjustment and Autoregressive Integrated Moving Average. The prediction errors are analyzed and compared with the ones obtained from the traditional Seasonal Autoregressive Integrated Moving Average model. The comparisons demonstrate that the proposed model can improve the prediction accuracy noticeably. © 2011 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "electricity price",
            "empirical mode decomposition",
            "seasonal adjustment",
            "prediction error",
            "seasonality",
            "power system",
            "electricity market",
            "moving average"
        ],
        "authors": [
            {
                "name": "Yao Dong",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "He Jiang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jie Wu",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2011
    },
    "7UU8IEx2": {
        "id": "7UU8IEx2",
        "title": "Using multi-output feedforward neural network with empirical mode decomposition based signal filtering for electricity demand forecasting",
        "abstract": "For accurate electricity demand forecasting, this paper proposes a novel approach, MFES, that combines a multi-output FFNN (feedforward neural network) with EMD (empirical mode decomposition)-based signal filtering and seasonal adjustment. In electricity demand forecasting, noise signals, caused by various unstable factors, often corrupt demand series. To reduce these noise signals, MFES first uses an EMD-based signal filtering method which is fully data-driven. Secondly, MFES removes the seasonal component from the denoised demand series and models the resultant series using FFNN model with a multi-output strategy. This multi-output strategy can overcome the limitations of common multi-step-ahead forecasting approaches, including error amplification and the neglect of dependency between inputs and outputs. At last, MFES obtains the final prediction by restoring the season indexes back to the FFNN forecasts. Using the half-hour electricity demand series of New South Wales in Australia, this paper demonstrates that the proposed MFES model improves the forecasting accuracy noticeably comparing with existing models. © 2012 Elsevier Ltd.",
        "keywords": [
            "electricity demand forecasting",
            "emd-based signal filtering",
            "feedforward neural network",
            "multi-output forecasting",
            "seasonal adjustment"
        ],
        "authors": [
            {
                "name": "Ning An",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Weigang Zhao",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Duo Shang",
                "org": "Stony Brook University State University of New York(State University of New York,State University of New York at Stony Brook,Stony Brook University),Stony Brook,United States"
            },
            {
                "name": "Erdong Zhao",
                "org": "North China Electric Power University(North China Electric Power University),Beijing,China"
            }
        ],
        "venue": "Energy",
        "year": 2013
    },
    "CCQ4A5SD": {
        "id": "CCQ4A5SD",
        "title": "A novel non-linear combination system for short-term wind speed forecast",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": ""
            },
            {
                "name": "Shiqi Wang",
                "org": ""
            },
            {
                "name": "Wendong Yang",
                "org": ""
            }
        ],
        "venue": "Renewable Energy",
        "year": 2019
    },
    "cPkGpseO": {
        "id": "cPkGpseO",
        "title": "Research on Real Estate Early Warning System Based on Decision Tree and Fuzzy Recognition Theory",
        "abstract": "This paper presents a pre-warning system developed to monitor and provide pre-warning to the governmental decision makers in real estate market, applying the grey relational analysis and model design method, with the fuzzy recognition theory based on decision tree and its effectiveness. The real estate early warning system has been designed successfully by the three sub-modules of feature selection on each non-terminating node, decision rule on each non-terminating node and a new fuzzy decision tree method, early warning for the real estate market. The article details analysis and recognition module, a set of factors are selected by grey relational analysis and fuzzy recognition early-warning method is used, which can monitor the real estate property market, is developed. Empirical results indicate that the pre-warning system can provide useful information to regulate the property market.",
        "keywords": [
            "fuzzy set theory",
            "grey systems",
            "decision making",
            "governmental decision maker",
            "decision rule",
            "model design method",
            "fuzzy recognition",
            "real estate early warning",
            "real estate market",
            "fuzzy membership function",
            "non-terminating node",
            "pre-warning system",
            "real estate early warning system",
            "fuzzy recognition theory",
            "prewarning system",
            "early warning",
            "economics",
            "new fuzzy decision tree",
            "decision tree",
            "real estate",
            "decision trees",
            "property market",
            "grey relational analysis",
            "classification algorithms",
            "early warning system",
            "feature extraction",
            "feature selection",
            "decision maker",
            "forecasting"
        ],
        "authors": [
            {
                "name": "Jian-zhou Wang",
                "org": ""
            },
            {
                "name": "Jin-xing Che",
                "org": ""
            },
            {
                "name": "Jin-zhao Liang",
                "org": ""
            },
            {
                "name": "Haiyan Lu",
                "org": ""
            }
        ],
        "venue": "FSKD (3)",
        "year": 2008
    },
    "hk2I5I6B": {
        "id": "hk2I5I6B",
        "title": "An Experimental Investigation of FNN Model for Wind Speed Forecasting Using EEMD and CS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "haiyan jiang",
                "org": ""
            },
            {
                "name": "bohui han",
                "org": ""
            },
            {
                "name": "qingping zhou",
                "org": ""
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2015
    },
    "8pVlwpiZ": {
        "id": "8pVlwpiZ",
        "title": "Comprehensive assessment of wind resources and the low-carbon economy: An empirical study in the Alxa and Xilin Gol Leagues of inner Mongolia, China",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "he jiang",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "yao dong",
                "org": ""
            },
            {
                "name": "haiyan lu",
                "org": ""
            }
        ],
        "venue": "Renewable & Sustainable Energy Reviews",
        "year": 2015
    },
    "N1Ka0Q91": {
        "id": "N1Ka0Q91",
        "title": "Combining forecasts of electricity consumption in China with time-varying weights updated by a high-order Markov chain model",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weigang zhao",
                "org": ""
            },
            {
                "name": "jianzhou wang",
                "org": ""
            },
            {
                "name": "haiyan lu",
                "org": ""
            }
        ],
        "venue": "Omega-international Journal of Management Science",
        "year": 2014
    },
    "5Et7iT7J": {
        "id": "5Et7iT7J",
        "title": "Optimal parameters estimation and input subset for grey model based on chaotic particle swarm optimization algorithm",
        "abstract": "Optimum prediction is a difficult problem, because there are no optimal models for all forecasting problems. In this paper, the authors attempt to find the high precision prediction for grey forecasting model (GM). Considering that chaotic particle swarm optimization algorithm (CPSO) will not get into local optimum and is easy to implement, the paper develops an approach for grey forecasting model, which is particularly suitable for small sample forecasting, based on chaotic particle swarm optimization and optimal input subset which is a new concept. The input subset of traditional time series consists of the whole original data, but the whole original does not always reflect the internal regularity of time series, so the new optimal subset method is proposed to better reflect the internal characters of time series and improve the prediction precision. The numerical simulation result of financial revenue demonstrates that developed algorithm provides very remarkable results compared to traditional grey forecasting model for small dataset forecasting.",
        "keywords": [
            "grey forecasting model",
            "time series",
            "grey model",
            "small sample forecasting",
            "high precision prediction",
            "traditional grey forecasting model",
            "optimal input subset",
            "small dataset forecasting",
            "input subset",
            "chaotic particle swarm optimization algorithm",
            "chaotic particle swarm optimization",
            "new optimal subset method",
            "optimal parameters estimation",
            "forecasting problem",
            "numerical simulation",
            "parameter estimation"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, PR China"
            },
            {
                "name": "Suling Zhu",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, PR China"
            },
            {
                "name": "Weigang Zhao",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, PR China"
            },
            {
                "name": "Wenjin Zhu",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, PR China"
            }
        ],
        "venue": "Expert Syst. Appl.",
        "year": 2011
    },
    "HK9mBf5J": {
        "id": "HK9mBf5J",
        "title": "The Application of PBL Teaching Method in the Teaching of Pharmacology",
        "abstract": "Objective:the teaching method of Problem-Based Learning is applied in the teaching of pharmacology.The followings are the methods and the result the writers adopt and get.Methods:the Problem-Based Teaching method was put into application in the class of Anaesthesia Speciality of Grade 2004.The writers made an analysis of this teaching by way of questionnaire.Result:The questionnaire shows that a remarkable difference exists between the problem-based teaching method and the traditional one both in the students'study attitude,their ability,quality and speciality study.The conclusion is that the former one is much better than the latter one.",
        "keywords": [
            "Problem-based learning",
            "Pharmacology",
            "Practice"
        ],
        "authors": [
            {
                "name": "LAN Xing-lian",
                "org": "Department of Pharmacology,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "PAN Long-rui",
                "org": "Department of Pharmacology,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "GONG Xin-rong",
                "org": "Department of Pharmacology,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "YU Long-shun",
                "org": "Department of Pharmacology,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "LU Juan",
                "org": "Department of Pharmacology,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Pharmacology,Yunyang Medical College,Shiyan ,China"
            }
        ],
        "venue": "Researches in Medical Education",
        "year": 2007
    },
    "ZFDm32t0": {
        "id": "ZFDm32t0",
        "title": "Analysis of Statistical Deficiencies in Original Articles of an Academic Journal",
        "abstract": "Objective To investigate the status of statistical deficiencies in the original articles of an academic journal.Methods Totally 320 original articles published in an academic journal during the period of 1999～2007 were statistically analyzed.Results The total incidence rate of statistical deficiencies was 53.1%.The average incidence rate of descriptive statistical deficiencies was 15.6%,and the average incidence rate of inferential statistical deficiencies was 51.2%.The percentages of 6 inferential statistical deficiencies were 7.3%,54.3%,1.2%,3.1%,17.7%,and 6.7%,respectively.And the most common deficiency was that the statistical method did not accord with types of design.The incidence rate fell gradually from 1999 to 2007.Conclusions The incidence rate of statistical deficiencies of original articles published in the journal fell year by year,but it was higher than that of Chinese core medical journals.It is necessary to pay more attention to familiar statistical deficiencies for authors and editors.",
        "keywords": [
            "Statistical analysis",
            "Periodical",
            "Deficiency"
        ],
        "authors": [
            {
                "name": "GUO Huai-lan",
                "org": "Department of Preventive Medicine,Yunyang Medical College,Shiyan ,Hubei,China"
            },
            {
                "name": "WANG Jing",
                "org": "Department of Preventive Medicine,Yunyang Medical College,Shiyan ,Hubei,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Preventive Medicine,Yunyang Medical College,Shiyan ,Hubei,China"
            }
        ],
        "venue": "Practical Preventive Medicine",
        "year": 2010
    },
    "0z3at29T": {
        "id": "0z3at29T",
        "title": "INVESTIGATION AND ANALYSIS OF COLLEGE STUDENTS' HIV/AIDS KNOWLEDGE AND ATTITUDE IN MEDICAL COLLEGE",
        "abstract": "[Objective] To find out the degree of the acquaintance of AIDS among the college students from freshman to senior in medical college for the past five years, which will help further improve health education. [Methods] The college stu-dents from freshman to senior were surveyed by KABP questionnaire. [Results] There were few differences on the HIV / AIDS basic knowledge among varied grades, but differences existed in the ways of spread and clinic treatments of AIDS among differ-ent professional students. The knowledge differences between male and female students were almost non-existent. Family educa-tion need to be strengthened in the HIV / AIDS knowledge, attitude, prevention, and so on. [Conclusion] In recent years students’ knowledge, attitude, clinic treatment and prevention on the HIV / AIDS has increased. Health education and health promotion must be multi-pronged and the whole of society \"you and I have taken part in\" could contain AIDS.",
        "keywords": [
            "Behavior",
            "College students",
            "Analysis",
            "AIDS",
            "Knowledge"
        ],
        "authors": [
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Preventive Medicine, Yunyang Medicine College, Shiyan , China"
            },
            {
                "name": "ZHANG Shun-yue",
                "org": "Department of Preventive Medicine, Yunyang Medicine College, Shiyan , China"
            },
            {
                "name": "GUO Huai-lan",
                "org": "Department of Preventive Medicine, Yunyang Medicine College, Shiyan , China"
            },
            {
                "name": "WANG J",
                "org": "Department of Preventive Medicine, Yunyang Medicine College, Shiyan , China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2009
    },
    "RTMtkk8y": {
        "id": "RTMtkk8y",
        "title": "Application of Problem-based Teaching Method in Teaching of Pharmacology",
        "abstract": "Objective To explore problem-based teaching method applied in pharmacology teaching.Methods Problem-based teaching method was used in the year 2004 undergraduate students of stomatology specialty.We made an analysis of this teaching method by questionnaire.Results The questionnaire showed remarkable differences between problem-based teaching method and the traditional one in the students' study attitude,abilities,quality and study of specialized knowledge.Conclusion Problem-based teaching method is obviously superior to the traditional teaching method.",
        "keywords": [
            "teaching result",
            "problem-based teaching method",
            "pharmacology"
        ],
        "authors": [
            {
                "name": "LAN Xing-lian",
                "org": "Department of Pharmacology"
            },
            {
                "name": "YU Long-shun",
                "org": "Department of Pharmacology"
            },
            {
                "name": "PAN Long-rui",
                "org": "Department of Pharmacology"
            },
            {
                "name": "GONG Xin-rong",
                "org": "Department of Pharmacology"
            },
            {
                "name": "ZHU Ke-gang",
                "org": "Department of Pharmacology"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Preventive Medicine,Yunyang Medical College,Shiyan ,China"
            }
        ],
        "venue": "Northwest Medical Education",
        "year": 2007
    },
    "IfVY9NTH": {
        "id": "IfVY9NTH",
        "title": "RESEARCH OF TEACHING OF PREVENTIVE MEDICINE SET FOR CLINICAL MEDICINE UNDERGRADUATES",
        "abstract": "[Objective] To enhance teaching of preventive medicine set for medical undergraduates specialized at clinical medicine.[Methods] Interest in preventive medicine,problems in teaching methods and contents were surveyed and a new all-around experiment was tried in partial students.[Results] Most of medical undergraduates specialized at clinical Medicine were not interested in preventive medicine,but were interested in SPSS and the all-around experiments were welcome by majority.[Conclusion] The results provide the foundation and new orientation for teaching innovation of preventive medicine.",
        "keywords": [
            "Research of teaching",
            "Clinical medicine",
            "Preventive medicine"
        ],
        "authors": [
            {
                "name": "GUO Huai-lan",
                "org": "Department of Preven-tive Medicine,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "WANG Jian-zhou",
                "org": "Department of Preven-tive Medicine,Yunyang Medical College,Shiyan ,China"
            },
            {
                "name": "WANG Jing",
                "org": "Department of Preven-tive Medicine,Yunyang Medical College,Shiyan ,China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2009
    },
    "ZAlOyozv": {
        "id": "ZAlOyozv",
        "title": "Multistep Forecasting for Short-Term Wind Speed Using an Optimized Extreme Learning Machine Network with Decomposition-Based Signal Filtering",
        "abstract": "Since wind fluctuates with strong variation even within a short-term period, it is quite difficult to describe the characteristics of wind or to estimate the power output that will be injected into the grid. In particular, short-term wind speed forecasting, an essential support for regulatory actions and short-term load dispatching planning during the operation of wind farms, is currently regarded as one of the most difficult problems to solve. This paper contributes to multistep forecasting for short-term wind speed by developing a three-stage hybrid approach named MECE; it is a combination of the ensemble empirical model decomposition (EEMD) method, cuckoo search (CS) algorithm, and extreme learning machine (ELM) method. As the first stage of the hybrid MECE approach, a signal filtering based on a decomposition and reconstruction strategy is adopted and copied by the EEMD method, and a denoised series can be obtained. Then, the CS-optimized ELM is designed as a novel learning method to construct a single layer feed-forward neural network (SLFN); the input weights and biases are determined by the CS algorithm instead of the random initialization within the original ELM. Next, a training and forecasting stage is taken; three different strategies are adopted for multistep forecasting. The chosen data sets are half-hour wind speed observations, including 16 samples, and the simulation indicates that the proposed MECE approach performs much better than the traditional ones when addressing short-term wind speed forecasting problems.",
        "keywords": [
            "Multi-step strategy",
            "Ensemble empirical model decomposition",
            "Cuckoo search",
            "Extreme learning machine",
            "Hybrid forecasting method"
        ],
        "authors": [
            {
                "name": "jing zhao",
                "org": "Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China"
            },
            {
                "name": "jianzhou wang",
                "org": "Dongbei Univ Finance & Econ, Sch Stat, Dalian 116025, Peoples R China"
            },
            {
                "name": "feng liu",
                "org": "Lanzhou Univ, Sch Math & Stat, Lanzhou 730000, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF ENERGY ENGINEERING",
        "year": 2016
    },
    "lsNe8ruX": {
        "id": "lsNe8ruX",
        "title": "An improved grey model optimized by multi-objective ant lion optimization algorithm for annual electricity consumption forecasting.",
        "abstract": "Abstract   Accurate and stable annual electricity consumption forecasting play vital role in modern social and economic development through providing effective planning and guaranteeing a reliable supply of sustainable electricity. However, establishing a robust method to improve prediction accuracy and stability simultaneously of electricity consumption forecasting has been proven to be a highly challenging task. Most previous researches only pay more attention to enhance prediction accuracy, which usually ignore the significant of forecasting stability, despite its importance to the effectiveness of forecasting models. Considering the characteristics of annual power consumption data as well as one criterion i.e. accuracy or stability is insufficient, in this study a novel hybrid forecasting model based on an improved grey forecasting mode optimized by multi-objective ant lion optimization algorithm is successfully developed, which can not only be utilized to dynamic choose the best input training sets, but also obtain satisfactory forecasting results with high accuracy and strong ability. Case studies of annual power consumption datasets from several regions in China are utilized as illustrative examples to estimate the effectiveness and efficiency of the proposed hybrid forecasting model. Finally, experimental results indicated that the proposed forecasting model is superior to the comparison models.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "Department of Software Engineering, University of Technology, Sydney, Australia"
            },
            {
                "name": "Wendong Yang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Tong Niu",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2018
    },
    "6McY1dVh": {
        "id": "6McY1dVh",
        "title": "Particle-swarm optimization of ensemble neural networks with negative correlation learning for forecasting short-term wind speed of wind farms in western China.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tao Ma",
                "org": "School of Mathematical and Computer Science, Ningxia Normal University, Guyuan, Ningxia 756000, China"
            },
            {
                "name": "Chen Wang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianjun Cheng",
                "org": "School of Information Science and Engineering, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Xiaoyun Chen",
                "org": "School of Information Science and Engineering, Lanzhou University, Lanzhou 730000, China"
            }
        ],
        "venue": "Inf. Sci.",
        "year": 2019
    },
    "y2GGonSF": {
        "id": "y2GGonSF",
        "title": "Distributed HS-ARTMAP and its forecasting model for electricity load",
        "abstract": "This paper proposes a new network named dHS-ARTMAP based on ARTMAP.The method reduces proliferation problems, retains stable memories, and enjoys noise tolerance.dHS-ARTMAP model achieves excellent results compared with other models. Intelligence technology develops quickly to predict and respond to the actions of electric power users to maintain a reliable and secure electricity infrastructure. This paper proposed a new on-line training network called distributed hyper-spherical ARTMAP (dHS-ARTMAP) to forecast the electricity load. The new model constructs a more compact network structure and largely decreases the proliferation problem that Fuzzy ARTMAP models usually encounter. Experiments of short-term electricity load forecasting are made with the data from Queensland, Australia. Results are compared with other methods. The effectiveness of the dHS-ARTMAP network proves itself a promising alternative to put into practical use.",
        "keywords": [],
        "authors": [
            {
                "name": "Xing Lu",
                "org": "School of Mathematical Sciences, Fudan University, 200433, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, 116025, China"
            },
            {
                "name": "Yuan Cai",
                "org": "School of Mathematics and Statistics, Lanzhou University, 730000, China"
            },
            {
                "name": "Jing Zhao",
                "org": "School of Mathematics and Statistics, Lanzhou University, 730000, China"
            }
        ],
        "venue": "Applied Soft Computing",
        "year": 2015
    },
    "MCwfHmJk": {
        "id": "MCwfHmJk",
        "title": "A hybrid short-term electricity price forecasting framework: Cuckoo search-based feature selection with singular spectrum analysis and SVM",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaobo Zhang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Yuyang Gao",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Energy Economics",
        "year": 2019
    },
    "CoBePSC1": {
        "id": "CoBePSC1",
        "title": "Bayesian regularisation neural network based on artificial intelligence optimisation",
        "abstract": "Stock prediction is generally considered to be challenging and known for its high noise and strong nonlinearities in financial time series analysis. However, current forecasting models ignore the importance of model parameter optimisation and the use of recent data. In this article, a novel forecasting approach with a Bayesian-regularised artificial neural networks (BR-ANN) was proposed. The weight of the proposed model (BR-ANN) is determined by the particle swarm optimisation (PSO) algorithm. Daily market prices and financial technical indicators are utilised as inputs to predict the one day future closing price of the Shanghai (in China) composite index. The Bayesian-regularised network uses a probabilistic nature for the network weights and can reduce the potential for over-fitting and over-training. Our empirical study and the results of our K-line theory analysis indicate that PSO is determined to be an effective algorithm to optimise the parameters of the Bayesian neural network compared with other ...",
        "keywords": "",
        "authors": [
            {
                "name": "Dingqi Yan",
                "org": "School of Mathematic and Statistic, Lanzhou University, Lanzhou, China"
            },
            {
                "name": "Qi Zhou",
                "org": "Sun Yat-sen Business School, Sun Yat-sen University, Guangzhou, China; School of Mathematic and Statistic, Lanzhou University, Lanzhou, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Na Zhang",
                "org": "School of Mathematic and Statistic, Lanzhou University, Lanzhou, China"
            }
        ],
        "venue": "International Journal of Production Research",
        "year": 2017
    },
    "8KNLVB6d": {
        "id": "8KNLVB6d",
        "title": "Improved v -Support vector regression model based on variable selection and brain storm optimization for stock price forecasting.",
        "abstract": "Display Omitted Original v-support vector regression is improved from two aspects.Principal component analysis is used to select suitable inputs for v-SVR.Brain storm optimization is first used to optimize three parameters of v-SVR.Two case studies of representative Chinese stock indices are presented.The developed hybrid model outperforms competing models for stock price forecast. Big data mining, analysis and forecasting always play a vital role in modern economic and industrial fields, and selecting an optimization model to improve time series forecasting accuracy is challenging. A support vector regression (SVR) model is widely used forecasting and data processing, but the individual SVR cannot always satisfy the requirements of time series forecasting. In this paper, a hybrid v-SVR model is developed and combined with principal component analysis (PCA) and brain storm optimization (BSO) for stock price index forecasting. Correlation analysis and PCA are conducted initially to select the input variables of the v-SVR from 20 technical indicators, while the advanced BSO algorithm is used to search for optimal parameters of v-SVR. Case studies of the China Securities Index 300 (CSI300) and the Shenzhen Stock Exchange Component Index (SZSE Component Index) are examined as illustrative examples to evaluate the effectiveness and efficiency of the developed hybrid forecast strategy. Numerical results indicate that the developed hybrid model is not only simple but also able to satisfactorily approximate the actual CSI300stock price index, and it can be an effective tool in stock market mining and analysis.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Ru Hou",
                "org": "School of Mathematics & Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Chen Wang",
                "org": "School of Mathematics & Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Lin Shen",
                "org": "School of Mathematics & Statistics, Lanzhou University, Lanzhou 730000, China"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2016
    },
    "tCx6SNmd": {
        "id": "tCx6SNmd",
        "title": "A novel hybrid air quality early-warning system based on phase-space reconstruction and multi-objective optimization: A case study in China",
        "abstract": "Abstract   With the haze pollution occurred frequently in recent years, establishing an effective air quality early-warning system has become the top priority. Nowadays, researchers have provided numerous methods for air quality early-warning. However, the majority of studies ignores the significance of data preprocessing and air quality evaluation while designing an early-warning system, which leads to poor forecasting performance and insufficient information. A novel hybrid air quality early-warning system that consists of three modules: data preprocessing, forecasting and air quality evaluation module is designed in this paper. Aiming at extract chaotic characteristics of raw data, a new hybrid data preprocessing strategy is firstly developed to construct a more stable series of pollutant data for forecasting. Then a multi-objective grasshopper optimization algorithm is adopted in order to enhance the forecasting capability of accuracy and stability in the forecasting module. Moreover, a fuzzy evaluation module of air quality is proposed to provide comprehensive results for the system. Through the eighteen data sets’ experimental process, the results and discussions indicate that not only the forecasting method achieves higher accuracy and stronger stability than other comparison models, but also the evaluation module provides sufficient air quality information, which forms a scientific guidance to decision-makers against air pollution.",
        "keywords": "",
        "authors": [
            {
                "name": "Ying Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China"
            },
            {
                "name": "Zhiwu Li",
                "org": "Institute of Systems Engineering, Macau University of Science and Technology, Taipa, Macau, China"
            }
        ],
        "venue": "Journal of Cleaner Production",
        "year": 2020
    },
    "httrCvIi": {
        "id": "httrCvIi",
        "title": "A novel model",
        "abstract": "Display Omitted The set of bad subsamples is defined.The IBSM is proposed to confirm the set of bad subsamples.A novel method called DCANN is able to select the proper input for each output.The Optimization Algorithm is utilized to update the original DCANN.The proposed model has a minimum MAPE in the simulations conducted in four seasons. Big data mining, analysis, and forecasting always play a vital role in modern economic and industrial fields. Thus, how to select an optimization model to improve the forecasting accuracy of electricity price is not only an extremely challenging problem but also a concerned problem for different participants in an electricity market due to our society becoming heavily reliant on electricity. Many researchers developed hybrid models through the use of optimization methods, classical statistical models, artificial intelligence approaches and de-noising methods. However, few researchers aim to select reasonable samples and determine appropriate features when forecasting electricity price. Based on the Index of Bad Samples Matrix (IBSM), a novel method to dynamically confirm bad training samples, and the Optimization Algorithm (OA), DCANN and Updated DCANN are proposed in this paper for forecasting the day-ahead electricity price. This model is a hybrid system of supervised and unsupervised learning and creatively applies the idea of deleting bad samples and searching quality inputs to develop and learn, which is unlike BPANN, RBFN, SVM and LSSVM. Numerical results show that the proposed model is not only able to approximate the actual electricity price (normal or high volatility) but also an effective tool for h-step-ahead forecasting (h is less than 10) compared to benchmarks.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Feng Liu",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Yiliao Song",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Jing Zhao",
                "org": "State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China"
            }
        ],
        "venue": "Applied Soft Computing",
        "year": 2016
    },
    "Dbc6XISu": {
        "id": "Dbc6XISu",
        "title": "Hybrid forecasting model-based data mining and genetic algorithm-adaptive particle swarm optimisation: a case study of wind speed time series",
        "abstract": "Wind energy has been part of the fastest growing renewable energy sources and is clean and pollution-free. Wind energy has been gaining increasing global attention, and wind speed forecasting plays a vital role in the wind energy field. However, such forecasting has been demonstrated to be a challenging task due to the effect of various meteorological factors. This study proposes a hybrid forecasting model that can effectively provide preprocessing for the original data and improve forecasting accuracy. The developed model applies a genetic algorithm-adaptive particle swarm optimisation algorithm to optimise the parameters of the wavelet neural network (WNN) model. The proposed hybrid method is subsequently examined in regard to the wind farms of eastern China. The forecasting performance demonstrates that the developed model is better than some traditional models (for example, back propagation, WNN, fuzzy neural network, and support vector machine), and its applicability is further verified by the paired-sample T tests.",
        "keywords": [
            "data mining",
            "genetic algorithms",
            "particle swarm optimisation",
            "power engineering computing",
            "wavelet neural nets",
            "weather forecasting",
            "wind power",
            "WNN model",
            "eastern China",
            "genetic algorithm-adaptive particle swarm optimisation algorithm",
            "hybrid forecasting model-based data mining",
            "paired-sample T test",
            "renewable energy source",
            "wavelet neural network model",
            "wind energy",
            "wind farm",
            "wind speed forecasting",
            "wind speed time series"
        ],
        "authors": [
            {
                "name": "jianzhou wang",
                "org": "dongbei university of finance and economics"
            },
            {
                "name": "fanyong zhang",
                "org": "lanzhou university"
            },
            {
                "name": "feng liu",
                "org": "dongbei university of finance and economics"
            },
            {
                "name": "jianjun ma",
                "org": "lanzhou university"
            }
        ],
        "venue": "IET Renewable Power Generation",
        "year": 2016
    },
    "kcZ1xeY4": {
        "id": "kcZ1xeY4",
        "title": "A Novel Framework of Reservoir Computing for Deterministic and Probabilistic Wind Power Forecasting",
        "abstract": "The path towards wind power forecasting has yielded huge socio–economic benefits at a global scale. However, most of the previous studies tend to emphasize the improvement of deterministic forecasting, usually losing sight of the significance of probabilistic forecasting. In this paper, a novel forecasting system that can perform deterministic and probabilistic forecasting of wind power simultaneously, composed by the modules of feature selection, forecasting, system optimization, and system evaluation is presented to further supplement the existing studies in this field. Concretely, a hybrid feature selection strategy is proposed in the feature selection module to determine optimal system input; superior to traditional gradient descent algorithm, a dynamic reservoir theory-based recurrent neural network is developed in the forecasting module; an enhanced multi-objective optimization algorithm with the objectives of accuracy and stability is proposed in the system optimization module to provide an optimal scenario for system parameters; the effectiveness and feasibility of the proposed system is then validated in the evaluation module. Moreover, the comprehensive performance analysis of the proposed system is investigated in depth. Finally, the experimental results demonstrate that the proposed system has a significant advantage over the benchmarks considered, further verifying its tremendous potential to be used in a practical wind power system.",
        "keywords": [
            "Forecasting",
            "Wind power generation",
            "Computational modeling",
            "Reservoirs",
            "Predictive models",
            "Feature extraction",
            "Probabilistic logic"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Tong Niu",
                "org": "Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "Department of Software Engineering, University of Technology, Sydney, NSW, Australia"
            },
            {
                "name": "Wendong Yang",
                "org": "Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Pei Du",
                "org": "Dongbei University of Finance and Economics, Dalian, China"
            }
        ],
        "venue": "IEEE Transactions on Sustainable Energy",
        "year": 2020
    },
    "UEsakdSF": {
        "id": "UEsakdSF",
        "title": "Developing an early-warning system for air quality prediction and assessment of cities in China",
        "abstract": "An early-warning system is developed for air quality.Pollutant emission characteristics are analyzed using distribution functions.Dynamic forecast intervals are constructed for addressing the uncertainty.Air quality is evaluated by integrating fuzzy set theory and AHP.The results show that the developed early-system is effective and reliable. Air quality has received continuous attention from both environmental managers and citizens. Accordingly, early-warning systems for air pollution are very useful tools to avoid negative health effects and develop effective prevention programs. However, developing robust early-warning systems is very challenging, as well as necessary. This paper develops a reliable and effective early-warning system that consists of air quality prediction and assessment modules. In the prediction module, a hybrid forecasting method is developed for predicting pollutant concentrations that effectively estimates future air quality conditions. In developing this proposed model, we suggest the use of a back propagation neural network algorithm, combined with a probabilistic parameter model and data preprocessing techniques, to address the uncertainties involved in future air quality prediction. Meanwhile, a pre-analysis is implemented, primarily by using optimized distribution functions to examine and analyze statistical characteristics and emission behaviors of air pollutants. The second method, which is developed as part of the second module, is based on fuzzy set theory and the Analytic Hierarchy Process, and it performs air quality assessments to provide a clear and intelligible description of air quality conditions. Using data from the Ministry of Environmental Protection of China and six stages of air quality classification levels, specifically good, moderate, lightly polluted, moderately polluted, heavily polluted and severely polluted, two cities in China, Chengdu and Hangzhou, are used as illustrative examples to verify the effectiveness of the developed early-warning system. The results demonstrate that the proposed methods are effective and reliable for use by environmental supervisors in air pollution monitoring and management.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Xiaobo Zhang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Zhenhai Guo",
                "org": "State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "School of Software, Faculty of Engineering and Information Technology, University of Technology, Sydney, Australia"
            }
        ],
        "venue": "Expert Syst. Appl.",
        "year": 2017
    },
    "ru0XYAsj": {
        "id": "ru0XYAsj",
        "title": "Research on a combined model based on linear and nonlinear features - A case study of wind speed forecasting",
        "abstract": "As one of the most promising sustainable energy sources, wind energy is being paid more attention by the researchers. Because of the volatility and instability of wind speed series, wind power integration faces a severe challenge; thus, an accurate wind energy forecasting plays a key role in smart grid planning and management. However, many traditional forecasting models do not consider the necessity and importance of data preprocessing and neglect the limitation of using a single forecasting model, which leads to poor forecasting accuracy. To solve these problems, a novel combined model based on two linear and four nonlinear forecasting algorithms is proposed to adapt both the linear and nonlinear characteristics of the wind energy time series. In addition, a modified Artificial Fish Swarm Algorithm and Ant Colony Optimization (AFSA-ACO) algorithm is proposed and employed to determine the optimal weight coefficients of the combined models. To verify the forecasting performance of the developed combined model, several experiments were implemented by using 10-min interval wind speed data in Shandong, China. Then, one-step (10-min), three-step (30-min) and five-step (50-min) predictions were conducted. The experimental results indicate that the developed combined model is remarkably superior to all benchmark models for the high precision and stability of wind-speed predictions.",
        "keywords": "",
        "authors": [
            {
                "name": "Kequan Zhang",
                "org": "A Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Zongxi Qu",
                "org": "A Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Yunxuan Dong",
                "org": "School of Mathematics and Statics, Lanzhou University, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "Faculty of Engineering and Information Technology, University of Technology, Sydney, Australia"
            },
            {
                "name": "Wennan Leng",
                "org": "A Key Laboratory of Arid Climatic Change and Reducing Disaster of Gansu Province, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, China"
            },
            {
                "name": "Wenyu Zhang",
                "org": ""
            }
        ],
        "venue": "Renewable Energy",
        "year": 2019
    },
    "lq5w2R9A": {
        "id": "lq5w2R9A",
        "title": "Developing a Deep Learning Framework with Two-Stage Feature Selection for Multivariate Financial Time Series Forecasting",
        "abstract": "Abstract   Intelligent financial forecasting modeling plays an important role in facilitating investment-related decision-making activities in financial markets. However, accurate multivariate financial time series forecasting remains a challenge due to its complex nonlinear pattern. Aiming to fill the gap in the field, a novel forecasting framework, based on a two-stage feature selection model, deep learning model, and error correction model, is presented in this study, aiming at effectively capturing the nonlinearity inherent in multivariate financial time series. Concretely, the proposed two-stage feature selection model is utilized to determine the optimal feature set to further improve the generalization of the proposed deep learning model based on three deep learning units. Meanwhile, the error correction model is used to correct the forecasts and improve the accuracy further. To validate the performance of the forecasting framework, the case studies and the corresponding sensitivity analysis are carried out, consequently demonstrating its superiority, as compared to 16 benchmarks considered.",
        "keywords": "",
        "authors": [
            {
                "name": "Tong Niu",
                "org": "Center for Energy, Environment & Economy Research, Zhengzhou University, Zhengzhou, 450001, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "School of Computer Science, Faculty of Engineering and Information Technology, University of Technology Sydney, Australia"
            },
            {
                "name": "Wendong Yang",
                "org": "School of Computer Science, Faculty of Engineering and Information Technology, University of Technology Sydney, Australia"
            },
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China"
            }
        ],
        "venue": "Expert Syst. Appl.",
        "year": 2020
    },
    "3QM4UGYu": {
        "id": "3QM4UGYu",
        "title": "Container throughput forecasting using a novel hybrid learning method with error correction strategy.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Wendong Yang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Tong Niu",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Knowl.-Based Syst.",
        "year": 2019
    },
    "JPKzF70K": {
        "id": "JPKzF70K",
        "title": "A novel system for multi-step electricity price forecasting for electricity market management",
        "abstract": "Abstract   Electricity price forecasting is an important and challenging issue for all participants in the power market because of the wide application of electricity in our society and its inherent features. In this context, some current forecasting systems use data preprocessing and optimization for theoretical and practical achievements. However, some limitations to these systems exist which need to be urgently solved. First, future information is overdrawn in the data preprocessing stage of these forecasting systems, which is actually unknown in practical applications. The crucial question, therefore, is how to develop a forecasting system without using any future information. Second, the complex features of original nonlinear and nonstationary electricity price have a negative influence on the generalization ability of these previously developed models. To decrease the negative effects on management, a method to develop a forecasting system to improve the model’s generalization ability is required. Therefore, in this study, we developed an adaptive deterministic and probabilistic interval forecasting system for multi-step electricity price forecasting, which can present more valuable information to power market decision makers. Two cases and one comparative study are provided and analyzed to validate the performance of the developed system in multi-step electricity price forecasting. Furthermore, further discussions are presented to illustrate the significance of this study, thus proving that the results of the present study fill the present knowledge gap and provide some new future directions for related studies.",
        "keywords": "",
        "authors": [
            {
                "name": "Wendong Yang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Tong Niu",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2020
    },
    "ybLRP2XS": {
        "id": "ybLRP2XS",
        "title": "Uncertainty modeling for chaotic time series based on optimal multi-input multi-output architecture: Application to offshore wind speed",
        "abstract": "Abstract   Wind energy is attracting more attention with the growing demand for energy. However, the efficient development and utilization of wind energy are restricted due to the intermittency and randomness of wind speed. Although abundant investigations concerning wind speed forecasting have been conducted by numerous researchers, most of the studies merely attach importance to point forecasts, which cannot quantitatively characterize the uncertainties as developing intervals. In this study, a novel interval prediction architecture has been designed, aiming at constructing effective prediction intervals for a wind speed series, composed of a preprocessing module, a feature selection module, an optimization module, a forecast module and an evaluation module. The feature selection module, in cooperation with the preprocessing module, is developed to determine the optimal model input. Furthermore, the forecast module optimized by the optimization module is considered a predictor for giving prediction intervals. The experimental results shed light on the architecture that not only outperforms the benchmark models considered, but also has great potential for application to wind power systems.",
        "keywords": "",
        "authors": [
            {
                "name": "Tong Niu",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "Department of Software Engineering, University of Technology, Sydney, Australia"
            },
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2018
    },
    "yZmHLeCR": {
        "id": "yZmHLeCR",
        "title": "Application of a novel early warning system based on fuzzy time series in urban air quality forecasting in China.",
        "abstract": "Abstract   With atmospheric environmental pollution becoming increasingly serious, developing an early warning system for air quality forecasting is vital to monitoring and controlling air quality. However, considering the large fluctuations in the concentration of pollutants, most previous studies have focused on enhancing accuracy, while few have addressed the stability and uncertainty analysis, which may lead to insufficient results. Therefore, a novel early warning system based on fuzzy time series was successfully developed that includes three modules: deterministic prediction module, uncertainty analysis module, and assessment module. In this system, a hybrid model combining the fuzzy time series forecasting technique and data reprocessing approaches was constructed to forecast the major air pollutants. Moreover, an uncertainty analysis was generated to further analyze and explore the uncertainties involved in future air quality forecasting. Finally, an assessment module proved the effectiveness of the developed model. The experimental results reveal that the proposed model outperforms the comparison models and baselines, and both the accuracy and the stability of the developed system are remarkable. Therefore, fuzzy logic is a better option in air quality forecasting and the developed system will be a useful tool for analyzing and monitoring air pollution.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Hongmin Li",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Haiyan Lu",
                "org": "School of Software, Faculty of Engineering and Information Technology, University of Technology, Sydney, Australia"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2018
    },
    "YQ7YljyZ": {
        "id": "YQ7YljyZ",
        "title": "Research and application of a hybrid forecasting model based on secondary denoising and multi-objective optimization for an air pollution early warning system",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116023, RP China"
            },
            {
                "name": "Lu Bai",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116023, RP China"
            },
            {
                "name": "Siqi Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116023, RP China"
            },
            {
                "name": "Chen Wang",
                "org": "School of Mathematics & Statistics, Lanzhou University, Lanzhou, 730000, RP China"
            }
        ],
        "venue": "Journal of Cleaner Production",
        "year": 2019
    },
    "iJ8Eu5DH": {
        "id": "iJ8Eu5DH",
        "title": "Where is the future of China’s biogas? Review, forecast, and policy implications",
        "abstract": "This paper discusses the history and present status of different categories of biogas production in China, most of which are classified into rural household production, agriculture-based engineering production, and industry-based engineering production. To evaluate the future biogas production of China, five models including the Hubbert model, the Weibull model, the generalized Weng model, the H–C–Z model, and the Grey model are applied to analyze and forecast the biogas production of each province and the entire country. It is proved that those models which originated from oil research can also be applied to other energy sources. The simulation results reveal that China’s total biogas production is unlikely to keep on a fast-growing trend in the next few years, mainly due to a recent decrease in rural household production, and this greatly differs from the previous goal set by the official department. In addition, China’s biogas production will present a more uneven pattern among regions in the future. This paper will give preliminary explanation for the regional difference of the three biogas sectors and propose some recommendations for instituting corresponding policies and strategies to promote the development of the biogas industry in China.",
        "keywords": [
            "Biogas production",
            " China",
            " Temporal–spatial",
            " Forecast",
            " Policy"
        ],
        "authors": [
            {
                "name": "Lei Gu",
                "org": "College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, China"
            },
            {
                "name": "Yi-Xin Zhang",
                "org": "School of Mathematics and Statistics, Lanzhou University, Lanzhou, China"
            },
            {
                "name": "Jian-Zhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, China"
            },
            {
                "name": "Gina Chen",
                "org": "School of Law, Northwestern University, Chicago, USA"
            },
            {
                "name": "Hugh Battye",
                "org": "School of History and Culture, Lanzhou University, Lanzhou, China"
            }
        ],
        "venue": "Petroleum Science",
        "year": 2016
    },
    "1y0oOZUl": {
        "id": "1y0oOZUl",
        "title": "Research and application of local perceptron neural network in highway rectifier for time series forecasting.",
        "abstract": "Abstract   Time series forecasting is one of the most effective ways to settle the elusive problems of increased penetration of energy industry and financial field. In recent years, neural networks are utilized in time series forecasting owing to the rationality and practicability. However, neural networks always overrate the performance of training data, which results in underestimating the test error. In this work, four important training tactics are proposed for the training and modeling of the networks, which promote forecasting percentages of the convolutional networks and get a better extrapolation performance. The numerical simulation shows that the proposed methods have broader application in time series forecasting, it is not only effective for over-fitting problems but also has promoted the model accuracy considerably.",
        "keywords": "",
        "authors": [
            {
                "name": "Yunxuan Dong",
                "org": "School of Mathematics and Statistics, Lanzhou University, Gansu, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Zhen-hai Guo",
                "org": "State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 10029, China"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2018
    },
    "6T0leYyD": {
        "id": "6T0leYyD",
        "title": "An innovative hybrid model based on outlier detection and correction algorithm and heuristic intelligent optimization algorithm for daily air quality index forecasting.",
        "abstract": "Air pollution forecasting plays an important role in helping reduce air pollutant emission and guiding people's daily activities and warning the public in advance. Nevertheless, previous articles still have many shortcomings, such as ignoring the importance of outlier point detection and correction of original time series, and random initial parameters of models, and so on. A new hybrid model using outlier detection and correction algorithm and heuristic intelligent optimization algorithm is proposed in this study to address the above mentioned problems. First, data preprocessing algorithms are conducted to detect and correct outliers, excavate the main characteristics of the original time series; second, a widely used heuristic intelligent optimization algorithm is adopted to optimize the parameters of extreme learning machine to obtain the forecasting results of each subseries with improvement in accuracy; finally, experimental results and analysis show that the presented hybrid model provides accurate prediction, outperforming other comparison models, which emphasize the importance of outlier point detection and correction and optimization parameters of models, it also give a new feasible method for air pollution prediction, and contribute to make effective plans for air pollutant emissions.",
        "keywords": [
            "Air quality index",
            "Hybrid forecasting model",
            "Outlier detection and correction",
            "Sine cosine algorithm"
        ],
        "authors": [
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China."
            },
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China. Electronic address: renshengdp@126.com."
            },
            {
                "name": "Yan Hao",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China."
            },
            {
                "name": "Xin Ma",
                "org": "School of Science, Southwest University of Science and Technology, 621010, Mianyang, China."
            },
            {
                "name": "Tong Niu",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China."
            },
            {
                "name": "Wendong Yang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian, 116025, China."
            }
        ],
        "venue": "Journal of environmental management",
        "year": 2019
    },
    "ncFkzUq5": {
        "id": "ncFkzUq5",
        "title": "A novel hybrid model for short-term wind power forecasting",
        "abstract": "Abstract   Wind energy prediction has a significant effect on the planning, economic operation and security maintenance of the wind power system. However, due to the high volatility and intermittency, it is difficult to model and predict wind power series through traditional forecasting approaches. To enhance prediction accuracy, this study developed a hybrid model that incorporates the following stages. First, an improved complete ensemble empirical mode decomposition with adaptive noise technology was applied to decompose the wind energy series for eliminating noise and extracting the main features of original data. Next, to achieve high accurate and stable forecasts, an improved wavelet neural network optimized by optimization methods was built and used to implement wind energy prediction. Finally, hypothesis testing, stability test and four case studies including eighteen comparison models were utilized to test the abilities of prediction models. The experimental results show that the average values of the mean absolute percent errors of the proposed hybrid model are 5.0116% (one-step ahead), 7.7877% (two-step ahead) and 10.6968% (three-step ahead), which are much lower than comparison models.",
        "keywords": "",
        "authors": [
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Wendong Yang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Tong Niu",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Applied Soft Computing",
        "year": 2019
    },
    "1h0iDcVq": {
        "id": "1h0iDcVq",
        "title": "Predicting Beijing's tertiary industry with an improved grey model.",
        "abstract": "Abstract   In the context of the growth slowdown in China, it is important to accurately forecast the future economic trend to guide policy-makers the direction of adjusting their current economic policies. In this paper, we intend to predict Beijingu0027s tertiary industry, whose datasets are small, irregular and non-stationary, leading to a difficulty of building an accurate prediction model. To this end, we present an improved grey model, named PRGM(1,1), which extends the grey prediction model by integrating two techniques, i.e., the particle swarm optimization algorithm for parameter optimization and the exponential preprocessing method for data cleaning. The experimental results show that PRGM(1,1) outperforms other variants of the grey prediction model in predicting Beijingu0027s tertiary industry, and is viable to do reasonable prediction over short and fluctuated economic data sequences. In addition, we employ PRGM(1,1) in the economic prediction of Beijingu0027s tertiary industry in the next five years, and conclude that the growth rate will decelerate. Our prediction result seems to be in line with the economic slowdown in China this year.",
        "keywords": "",
        "authors": [
            {
                "name": "Qianru Wang",
                "org": "Faculty of Materials and Energy, Southwest University, Chongqing 400715, PR China"
            },
            {
                "name": "Li Liu",
                "org": "Ministry of Education, Key Laboratory of Dependable Service Computing in Cyber Physical Society, Chongqing 400044, PR China"
            },
            {
                "name": "Shu Wang",
                "org": "Faculty of Materials and Energy, Southwest University, Chongqing 400715, PR China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, PR China"
            },
            {
                "name": "Ming Liu",
                "org": "Faculty of Computer and Information Science, Southwest University, Chongqing 400715, PR China"
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2017
    },
    "EUKScHKg": {
        "id": "EUKScHKg",
        "title": "Research and application of a novel hybrid forecasting system based on multi-objective optimization for wind speed forecasting",
        "abstract": "Abstract   Accurate and stable wind speed forecasting is a crucial issue in the wind power industry, which has a significant effect on power system operation, power grid security and market economics. However, most prior articles only attach importance to improving the accuracy or stability, few of them focus on the accuracy and stability, simultaneously. Therefore, considering one criterion i.e. accuracy or stability is insufficient, in this study a novel powerful hybrid forecasting system is successfully developed, which contains four modules: data preprocessing module, optimization module, forecasting module and evaluation module. In this system, decomposing algorithm is applied to divide the original wind speed data into a finite set of components. Moreover, to achieve high accuracy and strong stability simultaneously, multi-objective ant lion optimization is employed to optimize the initial weights between layers and thresholds of the Elman neutral network in the optimization module, which overcomes the drawbacks of single-objective optimization algorithms. Finally, evaluation module including hypothesis testing and evaluation criteria is introduced to make a comprehensive evaluation for this system. The experimental results indicate that the average values of the mean absolute percent errors of the developed model utilizing 10-min, 30-min and 60-min interval data are 2.8220%, 5.0216% and 7.7205%, respectively, which are much lower than those of the comparison models.",
        "keywords": "",
        "authors": [
            {
                "name": "Pei Du",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Jianzhou Wang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            },
            {
                "name": "Zhenhai Guo",
                "org": "State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China"
            },
            {
                "name": "Wendong Yang",
                "org": "School of Statistics, Dongbei University of Finance and Economics, Dalian 116025, China"
            }
        ],
        "venue": "Energy Conversion and Management",
        "year": 2017
    },
    "HXBOH4XP": {
        "id": "HXBOH4XP",
        "title": "LIF Protection of Photoreceptor from Light Damage Correlates with Stat3 Activation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yumi ueki",
                "org": "university of oklahoma health sciences center"
            },
            {
                "name": "jianzhou wang",
                "org": "university of oklahoma health sciences center"
            },
            {
                "name": "s chollangi",
                "org": "university of oklahoma"
            },
            {
                "name": "j d ash",
                "org": "university of oklahoma health sciences center"
            }
        ],
        "venue": "Investigative Ophthalmology & Visual Science",
        "year": 2007
    },
    "o7d2N8Tm": {
        "id": "o7d2N8Tm",
        "title": "Hepatitis C and hepatitis B nucleic acids are present in intrahepatic cholangiocarcinomas from the United States.",
        "abstract": "Intrahepatic cholangiocarcinomas (IHCs) are rare in the United States, but the prevalence is steadily increasing and risk factors are poorly understood. Tissues were obtained at the time of surgical resection, and 11 cases of IHC were retrospectively studied for the presence of hepatitis B virus (HBV) DNA and hepatitis C virus (HCV) RNA. Hemi-nested and real-time polymerase chain reaction assays were used to detect HBV DNA, and nested reverse transcriptase-polymerase chain reaction was used to detect HCV RNA. Genotypes were determined for both HBV and HCV. The cases were predominantly from women (10/11), with an average age at surgery of 63 years and an average tumor size of 6 cm. Three cases (27%) were positive for either HBV or HCV nucleic acids: HBV alone (n = 1), HCV alone (1), coinfection with HBV and HCV (1). Both HBV-positive cases were genotype A, and both HCV cases were genotype 1a. Hepatitis B and C viral copy numbers were low in all cases. Evidence for active HBV replication was found in both HBV-positive cases, as they were positive for covalently closed circular DNA. In this study, 27% of ICC cases contained HBV and/or HCV nucleic acids, suggesting an etiologic role for these viruses in some cases of IHC.",
        "keywords": [
            "hepatitis b",
            "hepatitis c",
            "intrahepatic cholangiocarcinoma",
            "nucleic acid"
        ],
        "authors": [
            {
                "name": "Vivekanandan Perumal",
                "org": "Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Department of Anatomic Pathology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA"
            },
            {
                "name": "Paul Thuluvath",
                "org": "Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"
            },
            {
                "name": "Michael Choti",
                "org": "Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA"
            },
            {
                "name": "Michael Torbenson",
                "org": ""
            }
        ],
        "venue": "Human pathology",
        "year": 2006
    },
    "7azb56Ss": {
        "id": "7azb56Ss",
        "title": "Leiomyosarcoma of the breast: a pathologic and comparative genomic hybridization study of two cases.",
        "abstract": "Leiomyosarcoma is an extremely rare form of primary breast sarcoma. We present the pathologic and genetic findings of two cases of leiomyosarcoma of the breast. The patients were 44 and 52 years of age and they presented with circumscribed masses of 3.0 and 4.5 cm, (greatest dimension) respectively. Microscopically, the two tumors showed diffuse proliferation of spindle cells with oval and blunt-ended nuclei arranged in short fascicles or bundles. There was moderate cytologic atypia in both cases, and 6 and 12 mitotic figures per 10 high power fields, respectively. No epithelial component was identified. The tumor cells were strongly immunoreactive for markers of smooth-muscle differentiation, including desmin, muscle-specific actin, and smooth-muscle actin. Comparative genomic hybridization analysis showed losses of 10q (two of two cases), 13q (two of two cases), 17p (one of two cases), and gains of 1q (one of two cases) and 17p (one of two cases). The patterns of chromosomal imbalances identified in leiomyosarcoma of the breast are similar to those reported in leiomyosarcoma of soft tissue and uterus and are different from those reported for leiomyoma, indicating that these alterations may be important for development of malignant smooth-muscle tumors regardless of site or organ of origin.",
        "keywords": [
            "soft tissue",
            "genetics"
        ],
        "authors": [
            {
                "name": "Jiyun Lee",
                "org": "Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA"
            },
            {
                "name": "Shibo Li",
                "org": "Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA"
            },
            {
                "name": "Michael Torbenson",
                "org": "Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD USA"
            },
            {
                "name": "Qiong Z Liu",
                "org": "Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA"
            },
            {
                "name": "Stuart Lind",
                "org": "Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA"
            },
            {
                "name": "John J Mulvihill",
                "org": "Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA"
            },
            {
                "name": "Barbara Bane",
                "org": "Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK USA"
            },
            {
                "name": "Jianzhou Wang",
                "org": ""
            }
        ],
        "venue": "Cancer genetics and cytogenetics",
        "year": 2004
    },
    "PUcyRe9j": {
        "id": "PUcyRe9j",
        "title": "Hepatocellular carcinomas show abnormal expression of fibronectin protein.",
        "abstract": "Fibronectin plays an important role in cell-to-cell adhesion, cell migration, and cell signaling. In the liver, fibronectin expression has been studied primarily as a component of the extracellular matrix, but little information is available on the expression of fibronectin protein in the neoplastic cells of hepatocellular carcinomas (HCCs). Twenty-four surgically resected HCCs were immunostained with fibronectin. Tumor and normal liver tissues were concurrently analyzed in all cases, and expression in the tumor was evaluated in comparison to the nonneoplastic liver. The average age at resection was 54 +/- 18 years for the 18 men and 6 women. Twenty-one of the cases were classic HCCs including 6 cases that were well differentiated, 12 cases moderately differentiated, and 3 cases poorly differentiated. The remaining 3 cases were moderately differentiated fibrolamellar carcinomas. In the normal liver, fibronectin labeled the sinusoids and weakly to moderately stained the cytoplasm of hepatocytes. In HCCs, 15/24 showed overexpression of fibronectin in the cytoplasm, 8/24 showed no change from the nonneoplastic liver, and one case showed decreased cytoplasmic staining. In addition, an abnormal membranous staining pattern was noted in 16/24 HCCs. In contrast to the HCCs, none of the three fibrolamellar carcinomas showed increased cytoplasmic or membranous staining. Excluding fibrolamellar carcinoma, increased cytoplasmic staining and/or an abnormal membranous staining was noted in 19/21 (90%) of HCCs. Fibronectin shows abnormal cytoplasmic and/or membranous staining in the majority of HCCs. The implications of fibronectin overexpression are uncertain but may reflect a critical step in tumor genesis.",
        "keywords": [
            "apoptosis",
            " clinical pathology",
            " clinical chemistry",
            " surgical pathology",
            " cytopathology",
            " immunohistology",
            " and electron microscopy",
            " clinical biochemistry",
            " clinical microbiology",
            " hematopathology",
            " anatomic pathology",
            " coagulation",
            " cytogenetics",
            " histochemical stain",
            " immunohistochemical stain",
            " histology",
            " prognostic marker",
            " angiogenesis",
            " modpathol",
            " nature magazines",
            " nature publishing group."
        ],
        "authors": [
            {
                "name": "Michael Torbenson",
                "org": "johns hopkins hospital"
            },
            {
                "name": "Jianzhou Wang",
                "org": "university of oklahoma health sciences center"
            },
            {
                "name": "michael a choti",
                "org": "johns hopkins hospital"
            },
            {
                "name": "Raheela Ashfaq",
                "org": "university of texas southwestern medical center"
            },
            {
                "name": "Anirban Maitra",
                "org": "johns hopkins hospital"
            },
            {
                "name": "Robb E Wilentz",
                "org": "johns hopkins hospital"
            },
            {
                "name": "john k boitnott",
                "org": "johns hopkins hospital"
            }
        ],
        "venue": "Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc",
        "year": 2002
    },
    "QNqlA2sa": {
        "id": "QNqlA2sa",
        "title": "Stat3 is Essential for Chronic Stress-Induced Endogenous Protection of Photoreceptors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "j d ash",
                "org": "Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, Oklahoma"
            },
            {
                "name": "j wang",
                "org": "Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, Oklahoma"
            },
            {
                "name": "ana j chucairelliott",
                "org": "universidad nacional del sur"
            },
            {
                "name": "yumi ueki",
                "org": "Univ of Oklahoma Hlth Sci Ctr, Oklahoma City, Oklahoma"
            }
        ],
        "venue": "Investigative Ophthalmology & Visual Science",
        "year": 2010
    },
    "fKjxsvCO": {
        "id": "fKjxsvCO",
        "title": "Role of LIFR-gp130 Activation in Endogenous Neuroprotection of Retinal Photoreceptors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "s chollangi",
                "org": "university of oklahoma health sciences center"
            },
            {
                "name": "jianzhou wang",
                "org": "university of oklahoma health sciences center"
            },
            {
                "name": "yumi ueki",
                "org": "university of oklahoma health sciences center"
            },
            {
                "name": "j d ash",
                "org": "university of oklahoma health sciences center"
            }
        ],
        "venue": "Investigative Ophthalmology & Visual Science",
        "year": 2007
    },
    "rk7IPKJs": {
        "id": "rk7IPKJs",
        "title": "Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation.",
        "abstract": " Background: Survivin is a recently described anti-apoptotic protein that is suppressed by wild-type p53 and is overexpressed in 41–70% of hepatocellular carcinomas from Asia. Two alternatively spliced transcripts have also been described: anti-apoptotic survivin-ΔEx3 and non—anti-apoptotic survivin-2B. Survivin splice variant expression has not been studied in HCC, and little is known about survivin expression in hepatocellular carcinomas arising in other parts of the world, where risk factors are often different than they are in Asia.",
        "keywords": [
            "Hepatocellular carcinoma",
            " survivin",
            " p53"
        ],
        "authors": [
            {
                "name": "Rajesh Kannangai",
                "org": "Department of Pathology,The Johns Hopkins Hospital,Baltimore"
            },
            {
                "name": "Jianzhou Wang",
                "org": "Department of Pathology,University of Oklahoma,Oklahoma City"
            },
            {
                "name": "Qiong Z Liu",
                "org": "Department of Pathology,University of Oklahoma,Oklahoma City"
            },
            {
                "name": "Fikret Sahin",
                "org": "Department of Pathology,The Johns Hopkins Hospital,Baltimore"
            },
            {
                "name": "Michael Torbenson",
                "org": "Department of Pathology,The Johns Hopkins Hospital,Baltimore"
            }
        ],
        "venue": "International Journal of Gastrointestinal Cancer",
        "year": 2005
    },
    "Exa0PyCd": {
        "id": "Exa0PyCd",
        "title": "CliniQA : highly reliable clinical question answering system.",
        "abstract": "Evidence-based medicine (EBM) aims to apply the best available evidences gained from scientific method to clinical decision making. From the computer science point of view, the current bottleneck of applying EBM by a decision maker (either a patient or a physician) is the time-consuming manual retrieval, appraisal, and interpretation of scientific evidences from large volume of and rapidly increasing medical research reports. Patients do not have the expertise to do it. For physicians, study has shown that they usually have insufficient time to conduct the task. CliniQA tries to shift the burden of time and expertise from the decision maker to the computer system. Given a single clinical foreground question, the CliniQA will return a highly reliable answer based on existing medical research reports. Besides this, the CliniQA will also return the analyzed information from the research report to help users appraise the medical evidences more efficiently.",
        "keywords": [
            "evidence based medicine (ebm)",
            "natural language processing (nlp)",
            "question & answering system (qa)"
        ],
        "authors": [
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Huijia Zhu",
                "org": ""
            },
            {
                "name": "Peng Cai",
                "org": ""
            },
            {
                "name": "Lei Zhang",
                "org": ""
            },
            {
                "name": "Zhaoming Qui",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            }
        ],
        "venue": "MIE",
        "year": 2012
    },
    "fqVALEQ1": {
        "id": "fqVALEQ1",
        "title": "Density-Based Clustering over an Evolving Data Stream with Noise",
        "abstract": "Clustering is an important task in mining evolving data streams. Beside the limited memory and one-pass con- straints, the nature of evolving data streams implies the following requirements for stream clustering: no as- sumption on the number of clusters, discovery of clus- ters with arbitrary shape and ability to handle outliers. While a lot of clustering algorithms for data streams have been proposed, they oer no solution to the combi- nation of these requirements. In this paper, we present DenStream, a new approach for discovering clusters in an evolving data stream. The \"dense\" micro-cluster (named core-micro-cluster) is introduced to summarize the clusters with arbitrary shape, while the potential core-micro-cluster and outlier micro-cluster structures are proposed to maintain and distinguish the potential clusters and outliers. A novel pruning strategy is de- signed based on these concepts, which guarantees the precision of the weights of the micro-clusters with lim- ited memory. Our performance study over a number of real and synthetic data sets demonstrates the eective- ness and eciency",
        "keywords": [
            "of our method. keywords: data mining algorithms",
            "evolving data streams.",
            "density based clustering",
            "synthetic data"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Martin Ester",
                "org": ""
            },
            {
                "name": "Weining Qian",
                "org": ""
            },
            {
                "name": "Aoying Zhou",
                "org": ""
            }
        ],
        "venue": "SDM",
        "year": 2006
    },
    "Wx4zxABq": {
        "id": "Wx4zxABq",
        "title": "Efficient clustering of uncertain data streams",
        "abstract": "Clustering uncertain data streams has recently become one of the most challenging tasks in data management because of the strict space and time requirements of processing tuples arriving at high speed and the difficulty that arises from handling uncertain data. The prior work on clustering data streams focuses on devising complicated synopsis data structures to summarize data streams into a small number of micro-clusters so that important statistics can be computed conveniently, such as Clustering Feature (CF) (Zhang et al. in Proceedings of ACM SIGMOD, pp 103---114, 1996) for deterministic data and Error-based Clustering Feature (ECF) (Aggarwal and Yu in Proceedings of ICDE, 2008) for uncertain data. However, ECF can only handle attribute-level uncertainty, while existential uncertainty, the other kind of uncertainty, has not been addressed yet. In this paper, we propose a novel data structure, Uncertain Feature (UF), to summarize data streams with both kinds of uncertainties: UF is space-efficient, has additive and subtractive properties, and can compute complicated statistics easily. Our first attempt aims at enhancing the previous streaming approaches to handle the sliding-window model by using UF instead of old synopses, inclusive of CluStream (Aggarwal et al. in Proceedings of VLDB, 2003) and UMicro (Aggarwal and Yu in Proceedings of ICDE, 2008). We show that such methods cannot achieve high efficiency. Our second attempt aims at devising a novel algorithm, cluUS , to handle the sliding-window model by using UF structure. Detailed analysis and thorough experimental reports on synthetic and real data sets confirm the advantages of our proposed method.",
        "keywords": [
            "clustering",
            "sliding-window model",
            "uncertain stream"
        ],
        "authors": [
            {
                "name": "Cheqing Jin",
                "org": "Shanghai Key Laboratory of Trustworthy Computing, Software Engineering Institute,East China Normal University,Shanghai,China"
            },
            {
                "name": "Jeffrey Xu Yu",
                "org": "Department of S.E.E.M,Chinese University of Hong Kong,Hong Kong,China"
            },
            {
                "name": "Aoying Zhou",
                "org": "Shanghai Key Laboratory of Trustworthy Computing, Software Engineering Institute,East China Normal University,Shanghai,China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM Research - China,Shanghai,China"
            }
        ],
        "venue": "Knowl. Inf. Syst.",
        "year": 2014
    },
    "tRuHsrtg": {
        "id": "tRuHsrtg",
        "title": "Tracking clusters in evolving data streams over sliding windows",
        "abstract": "Mining data streams poses great challenges due to the limited memory availability and real-time query response requirement. Clustering an evolving data stream is especially interesting because it captures not only the changing distribution of clusters but also the evolving behaviors of individual clusters. In this paper, we present a novel method for tracking the evolution of clusters over sliding windows. In our SWClustering algorithm, we combine the exponential histogram with the temporal cluster features, propose a novel data structure, the Exponential Histogram of Cluster Features (EHCF). The exponential histogram is used to handle the in-cluster evolution, and the temporal cluster features represent the change of the cluster distribution. Our approach has several advantages over existing methods: (1) the quality of the clusters is improved because the EHCF captures the distribution of recent records precisely; (2) compared with previous methods, the mechanism employed to adaptively maintain the in-cluster synopsis can track the cluster evolution better, while consuming much less memory; (3) the EHCF provides a flexible framework for analyzing the cluster evolution and tracking a specific cluster efficiently without interfering with other clusters, thus reducing the consumption of computing resources for data stream clustering. Both the theoretical analysis and extensive experiments show the effectiveness and efficiency of the proposed method.",
        "keywords": [
            "individual cluster",
            "temporal cluster feature",
            "cluster evolution",
            "exponential histogram",
            "data stream clustering",
            "mining data stream",
            "in-cluster evolution",
            "cluster distribution",
            "specific cluster",
            "cluster tracking · evolving · data streams · sliding windows",
            "data stream",
            "real time",
            "response time",
            "tracking",
            "histogram",
            "data mining",
            "availability",
            "cluster analysis",
            "data structure",
            "data streams",
            "sliding window",
            "classification",
            "information extraction",
            "data analysis"
        ],
        "authors": [
            {
                "name": "Aoying Zhou",
                "org": "Fudan University, Department of Computer Science and Engineering, 200433, Shanghai, P.R. China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Lab, 100094, Beijing, P.R. China"
            },
            {
                "name": "Weining Qian",
                "org": "Fudan University, Department of Computer Science and Engineering, 200433, Shanghai, P.R. China"
            },
            {
                "name": "Cheqing Jin",
                "org": "Fudan University, Department of Computer Science and Engineering, 200433, Shanghai, P.R. China and East China University of Science and Technology, Department of Computer Science, 200237, Shanghai ..."
            }
        ],
        "venue": "Knowl. Inf. Syst.",
        "year": 2008
    },
    "IjfTLJuw": {
        "id": "IjfTLJuw",
        "title": "Translation system and method for SPARQL queries",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "gang hu",
                "org": ""
            },
            {
                "name": "li ma",
                "org": ""
            },
            {
                "name": "yue pan",
                "org": ""
            },
            {
                "name": "xing zhi sun",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "0utWyXgG": {
        "id": "0utWyXgG",
        "title": "RTS - an integrated analytic solution for managing regulation changes and their impact on business compliance",
        "abstract": "Governance, Risk Management and Compliance are key success factors for corporations. Every company worldwide must ensure a proper compliance level with current and future laws and regulations, but managing the dynamic nature of the regulatory environment is a challenge, for both small and medium business as well as large corporations. Specifically the challenge is knowing and interpreting which regulations impact a particular business. Governments and standard bodies keep producing new, revised legislation, and businesses today rely on employees and consultants for tracking and understanding impact on their operations. This paper introduces a novel prototype solution that addresses these concerns through the use of advanced text analytics. In particular the system is able to discover sources of regulatory content on the world wide web, track the changes to these regulations, extract metadata and semantic information and use these to provide a semantically guided comparison of regulation versions. Moreover, by leveraging the IBM DeepQA architecture, the solution is able to cross reference business objectives with the regulatory database and provide insights about the impact of new and revised laws on a company's business.",
        "keywords": [
            "integrated analytic solution",
            "novel prototype solution",
            "medium business",
            "understanding impact",
            "regulations impact",
            "regulatory content",
            "regulation change",
            "revised law",
            "reference business objective",
            "regulatory database",
            "regulatory environment",
            "business compliance",
            "particular business",
            "document processing",
            "question answering",
            "text analytics"
        ],
        "authors": [
            {
                "name": "Davide Pasetto",
                "org": "IBM T.J. Watson Research Center, Yorktown Heights, NY"
            },
            {
                "name": "Hubertus Franke",
                "org": "IBM T.J. Watson Research Center, Yorktown Heights, NY"
            },
            {
                "name": "Weihong Qian",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Zhili Guo",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Honglei Guo",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Dongxu Duan",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Yuan Ni",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Yingxin Pan",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Shenghua Bao",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Lab"
            },
            {
                "name": "Zhong Su",
                "org": "IBM China Research Lab"
            }
        ],
        "venue": "Conf. Computing Frontiers",
        "year": 2013
    },
    "edv7cRyA": {
        "id": "edv7cRyA",
        "title": "Improving physician practice efficiency by learning lab test ordering pattern.",
        "abstract": "The system of electronic medical records (EMR) has been widely used in physician practice. In China, physicians have the time pressure to provide care to many patients in a short period. Improving practice efficiency is a promising direction to mitigate this predicament. During the encounter, ordering lab test is one of the most frequent actions in EMR system. In this paper, our motivation is to save physician's time by providing lab test ordering list to facilitate physician practice. To this end, we developed weight based multi-label classification framework to learn to order lab test for the current encounter according to the historical EMR. Particularly, we propose to learn the physician-specific lab test ordering pattern as different physicians may have different practice behavior on the same population. Experimental results on the real data set demonstrate that physician-specific models can outperform the baseline.",
        "keywords": [
            "electronic medical records",
            "lab test",
            "multi-label classification",
            "physician-specific practice pattern"
        ],
        "authors": [
            {
                "name": "Peng Cai",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Weijia Shen",
                "org": ""
            },
            {
                "name": "Tao Zheng",
                "org": ""
            }
        ],
        "venue": "MedInfo",
        "year": 2013
    },
    "77csguEV": {
        "id": "77csguEV",
        "title": "Method and Apparatus for Providing the Information of Adverse Drug Effects",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "gang hu",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "yue pan",
                "org": ""
            },
            {
                "name": "wang xiaoyuan",
                "org": ""
            },
            {
                "name": "xing zhi sun",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "iw2Rlmrd": {
        "id": "iw2Rlmrd",
        "title": "Distributed Data Stream Clustering: A Fast EM-based Approach",
        "abstract": "Clustering data streams has been attracting a lot of research efforts recently. However, this problem has not received enough consideration when the data streams are generated in a distributed fashion, whereas such a scenario is very common in real life applications. There exist constraining factors in clustering the data streams in the distributed environment: the data records generated are noisy or incomplete due to the unreliable distributed system; the system needs to on-line process a huge volume of data; the communication is potentially a bottleneck of the system. All these factors pose great challenge for clustering the distributed data streams. In this paper, we proposed an EM-based (Expectation Maximization) framework to effectively cluster the distributed data streams, with the above fundamental challenges in mind. In the presence of noisy or incomplete data records, our algorithms learn the distribution of underlying data streams by maximizing the likelihood of the data clusters. A test-and-cluster strategy is proposed to reduce the average processing cost, which is especially effective for online clustering over large data streams. Our extensive experimental studies show that the proposed algorithms can achieve a high accuracy with less communication cost, memory consumption and CPU time.",
        "keywords": [
            "unreliable distributed system",
            "expectation-maximisation algorithm",
            "online clustering",
            "pattern clustering",
            "fast em-based approach",
            "data streams clustering",
            "expectation maximization framework",
            "distributed processing",
            "distributed data stream clustering",
            "distributed environment",
            "application software",
            "clustering algorithms",
            "sensor fusion",
            "expectation maximization",
            "data clustering",
            "gaussian processes",
            "distributed system",
            "testing"
        ],
        "authors": [
            {
                "name": "Aoying Zhou",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Ying Yan",
                "org": ""
            },
            {
                "name": "Chaofeng Sha",
                "org": ""
            },
            {
                "name": "Xiaofeng He",
                "org": ""
            }
        ],
        "venue": "ICDE",
        "year": 2007
    },
    "Q9ZILKy3": {
        "id": "Q9ZILKy3",
        "title": "Supporting Ontology-Based Dynamic Property and Classification in WebSphere Metadata Server",
        "abstract": "Metadata management is an important aspect of today's enterprise information systems. Metadata management systems are growing from toolspecific repositories to enterprise-wide metadata repositories. In this context, one challenge is the management of the evolving metadata whose schema or meta-model itself may evolve, e.g., dynamically-added properties, which are often hard to predict upfront at the initial meta-model design time; another challenge is to organize the metadata by semantically-rich classification schemes. In this paper, we present a practical system which provides support for users to dynamically manage semantically-rich properties and classifications in the IBM WebSphere Metadata Server (MDS) by integrating an OWL ontology repository. To enable the smooth acceptance of Semantic Web technologies for developers of commercial software which must run 24 hours/day, 7 days/week, the system is designed to consist of integrated modeling paradigms, with an integrated query language and runtime repository. Specifically, we propose the modeling of dynamic properties on structured metadata as OWL properties and the modeling of classification schemes as OWL ontologies for metadata classification. We present a natural extension to OQL (Object Query Language)-like query language to embrace dynamic properties and metadata classification. We also observe that hybrid storage, i.e., horizontal tables for structured metadata and vertical triple tables for dynamic properties and classification, is suitable for the storage and query processing of co-existing structured metadata and semantic metadata. We believe that our study and experience are not specific to MDS, but are valuable for the community trying to apply Semantic Web technologies to the structured data management area.",
        "keywords": [
            "metadata management",
            "ontology-based dynamic property",
            "semantic web technology",
            "dynamic property",
            "structured metadata",
            "metadata management system",
            "metadata classification",
            "websphere metadata server",
            "semantically-rich classification scheme",
            "classification scheme",
            "semantic metadata",
            "metadata repository",
            "object query language",
            "meta model",
            "structured data",
            "query language",
            "enterprise information system"
        ],
        "authors": [
            {
                "name": "Shengping Liu",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Yang Yang",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Guotong Xie",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Chen Wang",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Cassio Santos",
                "org": "IBM Software Group, Westborough, USA MA 01581"
            },
            {
                "name": "Bob Schloss",
                "org": "IBM Watson Research Center, Yorktown Heights, USA NY 10598"
            },
            {
                "name": "Yue Pan",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Kevin Shank",
                "org": "IBM Software Group, Westborough, USA MA 01581"
            },
            {
                "name": "John Colgrave",
                "org": "IBM Software Group, Westborough, USA MA 01581"
            }
        ],
        "venue": "International Semantic Web Conference",
        "year": 2008
    },
    "oQYI7L15": {
        "id": "oQYI7L15",
        "title": "An Effective SPARQL Support over Relational Databases",
        "abstract": "Supporting SPARQL queries over relational databases becomes an active topic recently. However, it has not received enough consideration when SPARQL queries include restrictions on values (i.e filter expressions), whereas such a scenario is very common in real life applications. Challenges to solve this problem come from two aspects, (1) databases aspect. In order to fully utilize the well-developed SQL optimization engine, the generated SQL query is desired to be a single statement. (2) SPARQL query aspect. A practical SPARQL query often embeds several filters, which require comparisons between RDF results of different types. The type of RDF resources needs to be dynamically determined in the translation. In this paper, we propose an effective approach to support SPARQL queries over relational databases, with the above challenges in mind. To ensure the seamless translation, a novel facet-based scheme is designed to handle filter expressions. Optimization strategies are proposed to reduce the complexity of the generated SQL query. Experimental results confirm the effectiveness of our proposed techniques.",
        "keywords": [
            "databases aspect",
            "rdf result",
            "sparql query",
            "well-developed sql optimization engine",
            "practical sparql query",
            "relational databases",
            "sparql query aspect",
            "optimization strategy",
            "sql query",
            "rdf resource",
            "effective sparql support",
            "relational database"
        ],
        "authors": [
            {
                "name": "Jing Lu",
                "org": "Shanghai Jiao Tong University, Shanghai, China 200030 and IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Li Ma",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Yong Yu",
                "org": "Shanghai Jiao Tong University, Shanghai, China 200030"
            },
            {
                "name": "Yue Pan",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            }
        ],
        "venue": "SWDB-ODBIS",
        "year": 2008
    },
    "6L1EBvfp": {
        "id": "6L1EBvfp",
        "title": "SMDM: enhancing enterprise-wide master data management using semantic web technologies",
        "abstract": "Motivated by evolving business requirements and novel enterprise applications, we propose and implement the Semantic Master Data Management (SMDM), a semantics-level enhancement to the existing MDM solutions. The SMDM system publishes relational-based master data as virtual RDF store, and injects instantaneous reasoning capabilities into semantic queries. Two kinds of ontologies are introduced to the system, the core MDM ontology and the external imported domain ontology. SMDM enables data linking among multi-domains, implicit relationship discovery, and declarative definition and extension of business policies and entities. Based on these functions, modern companies can customize their applications and services on demand within the MDM hub. In the demonstration, we build the system environment based on IBM's MDM solution, and run the use cases on the master data of an insurance company.",
        "keywords": [
            "master data",
            "business requirement",
            "smdm system",
            "existing mdm solution",
            "business policy",
            "relational-based master data",
            "core mdm ontology",
            "system environment",
            "mdm solution",
            "mdm hub",
            "semantic web technology",
            "enterprise-wide master data management",
            "use case",
            "data management"
        ],
        "authors": [
            {
                "name": "Xiaoyuan Wang",
                "org": "IBM China Research Lab, China"
            },
            {
                "name": "Xingzhi Sun",
                "org": "IBM China Research Lab, China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Lab, China"
            },
            {
                "name": "Li Ma",
                "org": "IBM China Research Lab, China"
            },
            {
                "name": "Nick Kanellos",
                "org": "IBM Software Group, Canada"
            },
            {
                "name": "Kang Zhang",
                "org": "Shanghai Jiao Tong University, China"
            },
            {
                "name": "Yue Pan",
                "org": "IBM China Research Lab, China"
            },
            {
                "name": "Yong Yu",
                "org": "Shanghai Jiao Tong University, China"
            }
        ],
        "venue": "PVLDB",
        "year": 2009
    },
    "9GaIZzpW": {
        "id": "9GaIZzpW",
        "title": "MeDetect: Domain Entity Annotation in Biomedical References Using Linked Open Data.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Li Tian",
                "org": ""
            },
            {
                "name": "Weinan Zhang",
                "org": ""
            },
            {
                "name": "Haofen Wang",
                "org": ""
            },
            {
                "name": "Chenyang Wu",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Yong Yu",
                "org": ""
            }
        ],
        "venue": "International Semantic Web Conference (Posters & Demos)",
        "year": 2012
    },
    "CcnqNsXE": {
        "id": "CcnqNsXE",
        "title": "Fine-grained clinical outcome extraction and polarity classification.",
        "abstract": "Clinical outcome information is helpful for clinicians to understand the effect of a given intervention. Generally speaking, the outcome generated by an intervention has several aspects, and each aspect has different polarity. In this work we adopt structure learning algorithm to extract fine-grained outcome information and then determine the polarity of each aspect by trained classifier. Word and POS features are integrated by structure learning algorithm. The performance is evaluated on our labeled dataset. Experimental results indicate that although POS information can improve the performance of fine-grained outcome extraction it should be leveraged carefully.",
        "keywords": [
            "adaboost",
            "outcome extraction",
            "polarity classification",
            "structured perceptron"
        ],
        "authors": [
            {
                "name": "Peng Cai",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Yuan Ni",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Huijia Zhu",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            }
        ],
        "venue": "Studies in health technology and informatics",
        "year": 2012
    },
    "UpQI4fZP": {
        "id": "UpQI4fZP",
        "title": "An Effective SPARQL Support over Relational Databases, Semantic Web, Ontologies and Databases: VLDB Workshop, SWDB-ODBIS 2007, Vienna, Austria, September 24, 2007, Revised …",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Lu",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Li Ma",
                "org": ""
            },
            {
                "name": "Yong Yu",
                "org": ""
            },
            {
                "name": "Yue Pan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "VoUCi3ra": {
        "id": "VoUCi3ra",
        "title": "Semantic Enhancement for Enterprise Data Management",
        "abstract": "Taking customer data as an example, the paper presents an approach to enhance the management of enterprise data by using Semantic Web technologies. Customer data is the most important kind of core business entity a company uses repeatedly across many business processes and systems, and customer data management (CDM) is becoming critical for enterprises because it keeps a single, complete and accurate record of customers across the enterprise. Existing CDM systems focus on integrating customer data from all customer-facing channels and front and back office systems through multiple interfaces, as well as publishing customer data to different applications. To make the effective use of the CDM system, this paper investigates semantic query and analysis over the integrated and centralized customer data, enabling automatic classification and relationship discovery. We have implemented these features over IBM Websphere Customer Center, and shown the prototype to our clients. We believe that our study and experiences are valuable for both Semantic Web community and data management community.",
        "keywords": [
            "business process",
            "semantic web community",
            "semantic web technology",
            "enterprise data management",
            "data management community",
            "enterprise data",
            "cdm system",
            "customer data management",
            "centralized customer data",
            "semantic enhancement",
            "core business entity",
            "customer data",
            "data management",
            "semantic web",
            "reasoning"
        ],
        "authors": [
            {
                "name": "Li Ma",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Xingzhi Sun",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Chen Wang",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Xiaoyuan Wang",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            },
            {
                "name": "Nick Kanellos",
                "org": "IBM Software Group, USA 78758-3415"
            },
            {
                "name": "Dan Wolfson",
                "org": "IBM Software Group, USA 78758-3415"
            },
            {
                "name": "Yue Pan",
                "org": "IBM China Research Laboratory, Beijing, China 100094"
            }
        ],
        "venue": "International Semantic Web Conference",
        "year": 2009
    },
    "PXrjARa0": {
        "id": "PXrjARa0",
        "title": "MeDetect: A LOD-Based System for Collective Entity Annotation in Biomedicine",
        "abstract": "With the ever-growing use of textual biomedical data, domain entity annotation has become very important in biomedicine. Previous works on annotating domain entities from biomedical references suffer from several issues, such as a data flexibility problem, language dependency, and limitations with respect to word sense disambiguation. Meanwhile, the Linked Open Data (LOD) Initiative aims at interlinking data from various open knowledge bases. The numbers of entities and properties describing semantic relationships between entities within the linked data cloud have become very large. In this paper, we propose a knowledge-incentive approach for entity annotation in biomedicine, and present Me Detect, a prototype system that we developed based on this approach. With this approach, we over-come the problems of previous works using LOD-based collective annotation. Finally, we present the results of experiments that verify the effectiveness and efficiency of our approach.",
        "keywords": [
            "lod-based system",
            "biomedical references",
            "medical information systems",
            "medetect",
            "language dependency",
            "previous work",
            "knowledge based systems",
            "domain entity annotation",
            "biomedical reference",
            "linked open data",
            "interlinking data",
            "annotating domain entity",
            "collective entity annotation",
            "data flexibility problem",
            "linked open data initiative",
            "textual biomedical data",
            "biomedicine",
            "bio-informatics",
            "knowledge-incentive approach",
            "lod-based collective annotation",
            "entity annotation",
            "text analysis",
            "word sense disambiguation",
            "open knowledge bases"
        ],
        "authors": [
            {
                "name": "Li Tian",
                "org": ""
            },
            {
                "name": "Weinan Zhang",
                "org": ""
            },
            {
                "name": "Antonis Bikakis",
                "org": ""
            },
            {
                "name": "Haofen Wang",
                "org": ""
            },
            {
                "name": "Yong Yu",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            }
        ],
        "venue": "Web Intelligence",
        "year": 2013
    },
    "XPERJQDy": {
        "id": "XPERJQDy",
        "title": "Mining information dependency in outpatient encounters for chronic disease care.",
        "abstract": "Chronic disease care, e.g., care of type 2 diabetes mellitus, is a long-term, complex process involving collaboration and coordination among multiple healthcare providers. To facilitate and accelerate the process, it is key to understand the information flow and identify the information dependency (e.g., temporal dependency of co-occurrence and sequential occurrence) during care provision, which is also the objective of this work. Since most health interventions and decisions are made in outpatient encounters for chronic patients, in this paper, we propose an approach to mine temporal information dependency in outpatient encounter records using sequential pattern mining techniques. By exploring the real data of over 10,000 type 2 diabetes patients from three hospitals, the proposed approach effectively works out sets of meaningful information dependency patterns for different patient groups. The discovered information dependency can be used to guide the information sharing between different health providers, and optimize the chronic disease care coordination.",
        "keywords": [
            "information dependency",
            "outpatient encounter",
            "type 2 diabetes mellitus",
            "data mining",
            "chronic disease care"
        ],
        "authors": [
            {
                "name": "Wen Sun",
                "org": "IBM Research - China, Beijing, China."
            },
            {
                "name": "Weijia Shen",
                "org": ""
            },
            {
                "name": "Xiang Li",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Haifeng Liu",
                "org": ""
            },
            {
                "name": "Guotong Xie",
                "org": ""
            }
        ],
        "venue": "MedInfo",
        "year": 2013
    },
    "3XyI7LaL": {
        "id": "3XyI7LaL",
        "title": "SMDM: Enhancing enterprisewide master data management using semantic web technologies",
        "abstract": "Motivated by evolving business requirements and novel en-terprise applications, we propose and implement the Se-mantic Master Data Management (SMDM), a semantics-level enhancement to the existing MDM solutions. The SMDM system publishes relational-based master data as vir-tual RDF store, and injects instantaneous reasoning capabil-ities into semantic queries. Two kinds of ontologies are intro-duced to the system, the core MDM ontology and the exter-nal imported domain ontology. SMDM enables data linking among multi-domains, implicit relationship discovery, and declarative definition and extension of business policies and entities. Based on these functions, modern companies can customize their applications and services on demand within the MDM hub. In the demonstration, we build the system environment based on IBM's MDM solution, and run the use cases on the master data of an insurance company. © 2009 VLDB Endowment.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Xiaoyuan Wang",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Xingzhi Sun",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Li Ma",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Nick Kanellos",
                "org": "International Business Machines(IBM),Armonk,United States"
            },
            {
                "name": "Kang Zhang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yue Pan",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Yong Yu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Proceedings of the VLDB Endowment",
        "year": 2009
    },
    "cxw4Xfk3": {
        "id": "cxw4Xfk3",
        "title": "MDS++: Supporting Ontology-based Dynamic Classification in WebSphere Metadata Server",
        "abstract": "Metadata management systems are growing from tool-specific repositories to enterprise-wide metadata repositori es. In this context, one challenge is the management of the evo lving metadata whose schema or meta-model itself may evolve, e.g., dynamically-added properties, which are often hard to predict upfront at the initial meta-model design time; anot her challenge is to organize the metadata by semantically-rich class ification schemes. In this paper, we demonstrate a practical system which provides support for users to dynamically manage se mantically- rich properties and classifications in the IBM WebS phere Metadata Server (MDS) by integrating an OWL ontology repository. To enable the smooth acceptance of Semantic Web technologies, the system is designed to consist of integrated modeling paradigms, with an integrated query language and runtime repository.",
        "keywords": [
            "meta model",
            "query language"
        ],
        "authors": [
            {
                "name": "Shengping Liu",
                "org": ""
            },
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Guo Tong Xie",
                "org": ""
            },
            {
                "name": "Chen Wang",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Cassio Santos",
                "org": ""
            },
            {
                "name": "Robert J. Schloss",
                "org": ""
            },
            {
                "name": "Yue Pan",
                "org": ""
            },
            {
                "name": "Kevin Shank",
                "org": ""
            },
            {
                "name": "John Colgrave",
                "org": ""
            }
        ],
        "venue": "International Semantic Web Conference (Posters & Demos)",
        "year": 2008
    },
    "1139d4t9": {
        "id": "1139d4t9",
        "title": "Automatic information extraction for computerized clinical guideline.",
        "abstract": "Clinical Guidelines (CG) are recommendations on the appropriate treatment and care of people with specific diseases and conditions. CG should be used by both physicians and patients to make the informed decision. However, the CGs are not well used due to their complexity and because they are frequently updated. The computerized CGs are proposed to make use of the computer to do the decision making. However, it needs a lot of human effort to transform the narrative CG into computerized CG. In this paper, we proposed a method to use the NLP techniques to extract the fine-grained information from the text based CG automatically. Such information could be easily converted to the computer interpretable models.",
        "keywords": [
            "clinical guideline",
            "information extraction"
        ],
        "authors": [
            {
                "name": "Huijia Zhu",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Peng Cai",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            }
        ],
        "venue": "MedInfo",
        "year": 2013
    },
    "qQBVmdbu": {
        "id": "qQBVmdbu",
        "title": "Effective and efficient semantic web data management over DB2",
        "abstract": "With the fast growth of Semantic Web, more and more RDF data and ontologies are created and widely used in Web applications and enterprise information systems. It is reported that the W3C Linking Open Data community project consists of over two billion RDF triples, which are interlinked by about three million RDF links. Recently, efficient RDF data management on top of relational databases gains particular attentions from both Semantic Web community and database community. In this paper, we present effective and efficient Semantic Web data management over DB2, including efficient schema and indexes design for storage, practical ontology reasoning support, and an effective SPARQL-to-SQL translation method for RDF query. Moreover, we show the performance and scalability of our system by an evaluation among well-known RDF stores and discuss future work.",
        "keywords": [
            "Ontology",
            "RDF",
            "Semantic web",
            "SPARQL",
            "Triple store"
        ],
        "authors": [
            {
                "name": "Li Ma",
                "org": "IBM China Research Lab, BeiJing, China"
            },
            {
                "name": "Chen Wang",
                "org": "IBM China Research Lab, BeiJing, China"
            },
            {
                "name": "Jing Lu",
                "org": "Shanghai JiaoTong University, ShangHai, China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Lab, BeiJing, China"
            },
            {
                "name": "Yue Pan",
                "org": "IBM China Research Lab, BeiJing, China"
            },
            {
                "name": "Yong Yu",
                "org": "Shanghai JiaoTong University, Shang Hai, China"
            }
        ],
        "venue": "SIGMOD Conference",
        "year": 2008
    },
    "ybmpR02h": {
        "id": "ybmpR02h",
        "title": "Automatic extracting of patient-related attributes: disease, age, gender and race.",
        "abstract": "In the Evidence-based Medicine (EBM), PICO format is designed to easily and correctly search for the best available evidence. As the main element of PICO, the Patient/Problem (P) represents the attributes of patient in the clinical question and studies. In order to better understand the clinical problems, patient attribute identification is crucial and indispensable. Due to the richness of the human nature language, many issues like various term representations, grammar structures and abbreviations present challenges for automatically extracting the patient-related attributes from the unstructured data. In this paper, we employed the nature language processing (NLP) technologies to deeply analyze the linguistic characteristics of the attributes. Based on the NLP analysis results, we built the rule sets for different attributes and applied the rule-based approach to extract the patient-related attributes.",
        "keywords": [
            "natural language processing (nlp)",
            "pico",
            "evidence based medicine (ebm)",
            "information extraction",
            "patient/population/problem"
        ],
        "authors": [
            {
                "name": "Huijia Zhu",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Yuan Ni",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Peng Cai",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Zhaoming Qiu",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China Research Laboratory(IBM China Research Laboratory,IBM China Research Lab.,IBM China Research Lab),Beijing,China"
            }
        ],
        "venue": "Studies in health technology and informatics",
        "year": 2012
    },
    "mmQWNDCc": {
        "id": "mmQWNDCc",
        "title": "METHOD AND APPARATUS FOR PROCESSING MEDICAL DATA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "xiang li",
                "org": ""
            },
            {
                "name": "jing mei",
                "org": ""
            },
            {
                "name": "yuan ni",
                "org": ""
            },
            {
                "name": "weijia shen",
                "org": ""
            },
            {
                "name": "wen sun",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "AsowLC1R": {
        "id": "AsowLC1R",
        "title": "SPOCS : a smarter point of care system for coordinated chronic disease management.",
        "abstract": "null",
        "keywords": [
            "chronic disease management",
            "coordinated care",
            "physician practice pattern"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Weijia Shen",
                "org": ""
            },
            {
                "name": "Wen Sun",
                "org": ""
            },
            {
                "name": "Xiang Li",
                "org": ""
            },
            {
                "name": "Tao Zheng",
                "org": ""
            }
        ],
        "venue": "MedInfo",
        "year": 2013
    },
    "125qZz8B": {
        "id": "125qZz8B",
        "title": "Using data mining techniques on discovering physician practice patterns regarding to medication prescription - an exploratory study.",
        "abstract": "In this paper, we propose a data mining method for exploring the decision-making processes of physicians from electronic patient records and test it on the medical records of patients with type-2 diabetes mellitus. This method runs in two modes: general and partitioned. In the general mode, it mines rules from the whole medical records. In the partitioned mode, with a given partition factor, medical records are assigned into categories and a corresponding set of rules will be discovered for each category. Medication prescription predictions can be provided based on these rules. By comparing mined rules and prescription prediction accuracy under different modes, we discover that: 1) both the averaged precision and recall rate of the general mode can reach around 80%; 2) physicians tend to conform to the guideline instead of having their own preferences; 3) the medication decision can be affected by some hidden factors. These findings suggest this method show promise in discovering physician practice patterns and obtaining insights from real medical records.",
        "keywords": [
            "clinical decision support system",
            "practice pattern analysis",
            "prescription prediction",
            "type-2 diabetes"
        ],
        "authors": [
            {
                "name": "Jianzhou Feng",
                "org": ""
            },
            {
                "name": "Weijia Shen",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Yuan Ni",
                "org": ""
            },
            {
                "name": "Peng Cai",
                "org": ""
            },
            {
                "name": "Wen Sun",
                "org": ""
            },
            {
                "name": "Xiang Li",
                "org": ""
            }
        ],
        "venue": "MedInfo",
        "year": 2013
    },
    "ijlJputH": {
        "id": "ijlJputH",
        "title": "Adaptive scheduling for shared window joins over data streams",
        "abstract": "Recently a few Continuous Query systems have been developed to cope with applications involving continuous data streams. At\n the same time, numerous algorithms are proposed for better performance. A recent work on this subject was to define scheduling\n strategies on shared window joins over data streams from multiple query expressions. In these strategies, a tuple with the\n highest priority is selected to process from multiple candidates. However, the performance of these static strategies is deeply\n influenced when data are bursting, because the priority is determined only by static information, such as the query windows,\n arriving order, etc. In this paper, we propose a novel adaptive strategy where the priority of a tuple is integrated with\n realtime information. A thorough experimental evaluation has demonstrated that this new strategy can outperform the existing\n strategies.",
        "keywords": [
            "data streams",
            "continuous query",
            "shared window joins"
        ],
        "authors": [
            {
                "name": "Cheqing Jin",
                "org": "East China University of Science and Technology Department of Computer Science and Engineering Shanghai 200237 China"
            },
            {
                "name": "Aoying Zhou",
                "org": "Fudan University Department of Computer Science and Engineering Shanghai 200433 China"
            },
            {
                "name": "Jeffrey Xu Yu",
                "org": "The Chinese University of Hong Kong Department of Systems Engineering and Engineering Management China"
            },
            {
                "name": "Joshua Zhexue Huang",
                "org": "The University of Hong Kong E-Business Technology Institute China"
            },
            {
                "name": "Feng Cao",
                "org": "IBM China-Research Lab Beijing 100094 China"
            }
        ],
        "venue": "Frontiers of Computer Science in China",
        "year": 2007
    },
    "xLenYJRr": {
        "id": "xLenYJRr",
        "title": "Ontology-based knowledge management for personalized adverse drug events detection.",
        "abstract": "Since Adverse Drug Event (ADE) has become a leading cause of death around the world, there arises high demand for helping clinicians or patients to identify possible hazards from drug effects. Motivated by this, we present a personalized ADE detection system, with the focus on applying ontology-based knowledge management techniques to enhance ADE detection services. The development of electronic health records makes it possible to automate the personalized ADE detection, i.e., to take patient clinical conditions into account during ADE detection. Specifically, we define the ADE ontology to uniformly manage the ADE knowledge from multiple sources. We take advantage of the rich semantics from the terminology SNOMED-CT and apply it to ADE detection via the semantic query and reasoning.",
        "keywords": [
            "adverse drug events (ade) detection",
            "knowledge management",
            "ontology",
            "semantic reasoning"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Xingzhi Sun",
                "org": ""
            },
            {
                "name": "Xiaoyuan Wang",
                "org": ""
            },
            {
                "name": "Bo Li",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Yue Pan",
                "org": ""
            }
        ],
        "venue": "MIE",
        "year": 2011
    },
    "flAmi2NW": {
        "id": "flAmi2NW",
        "title": "Correlation between rational formation pressure and water cut",
        "abstract": "Formation pressure is one of the important marks to determine the state of formation energy, and thus the rational formationpressure needs to be determined. On the basis of the fundamental principle of petroleum engineering and relative permeability,the relational expression showing the correlation between the nondimensional fluid productivity index and productivity index and thewater cut are deduced. Then, according to the normalization processing of relative permeability curves from reservoirs and applying theprinciple of injection-production ratio, the paper presents the relationship between the rational pressure and water cut as well as injection-production under different oil production rate, and gives the practical application to oilfields. The result of study indicates that therational formation pressure maintenance will decrease dramatically when the nondimensional fluid productivity index or productivityindex takes the minimum value. This method has some scientific guidance and practical value for the analysis of the waterflood technologyand production rate of low-to-moderate water development phase.",
        "keywords": [
            "injection-production ratio",
            "oil production rate",
            "rational formation pressure",
            "water cut",
            "nondimensional fluid productivity index"
        ],
        "authors": [
            {
                "name": "GUO Fenzhuan",
                "org": " Southwest Petroleum University, Chengdu , China"
            },
            {
                "name": "TANG Hai",
                "org": " Southwest Petroleum University, Chengdu , China"
            },
            {
                "name": "LV Dongliang",
                "org": " Southwest Petroleum University, Chengdu , China"
            },
            {
                "name": "CAO Feng",
                "org": " CNPC Pipe Institute, Xi'an , China"
            }
        ],
        "venue": "Oil Drilling & Production Technology",
        "year": 2010
    },
    "KIbIm1fZ": {
        "id": "KIbIm1fZ",
        "title": "Discussions on the Stationary Supervision over the Production of Oil Casing Pipes",
        "abstract": "The stationary supervision of oil casing pipes takes an important role in the improvement of long,safe and reliable operation of oil casing pipes. Based on the experiences of supervising the production of oil casing pipes for many years in the Institute of Tubing Materials,several links of supervising the oil casing pipes are explained briefly. The ideas of stationary supervision over the oil casing pipes are presented in the paper,which are \"to enter the production as early as possible,track the whole process,and combine the supervision with the service\".",
        "keywords": [
            "oil casing pipes",
            "supervision over the production",
            "quality"
        ],
        "authors": [
            {
                "name": "Cao Feng",
                "org": ",et al"
            },
            {
                "name": "Wei Dong",
                "org": ",et al"
            },
            {
                "name": "Li Liang",
                "org": ",et al"
            }
        ],
        "venue": "Technology Supervision in Petroleum Industry",
        "year": 2010
    },
    "aiLPiwfx": {
        "id": "aiLPiwfx",
        "title": "Discussions on the Screw Quality Problem of ф508 mm Casing Tubes",
        "abstract": "It is difficult to process the screws of Φ508 mm casing tubes with high quality,which are caused by three aspects: tube diameter,manufacturing tube technology and screw parameter inspection.Then the paper studies the influential mechanism of tube diameter,manufacturing tube technology and screw inspection on the quality of screw processing,and systematically analyzes the reasons why it is difficult to control the screws processing quality of Φ508 mm casing tubes.Finally,one set of technologies about tube manufacturing,screw processing and inspection of Φ508 mm casing tubes are optimized according to the characteristics of present manufacturing tube techniques and screw processing technology.",
        "keywords": [
            "casing tubes",
            "quality",
            "production technology/processing technology",
            "inspection"
        ],
        "authors": [
            {
                "name": "Cao Feng",
                "org": ",et al"
            },
            {
                "name": "Xu Yanlin",
                "org": ",et al"
            },
            {
                "name": "Du Ailong",
                "org": ",et al"
            }
        ],
        "venue": "Technology Supervision in Petroleum Industry",
        "year": 2012
    },
    "LTAcHeC1": {
        "id": "LTAcHeC1",
        "title": "Defect Analysis and Testing Equipment Research of Drill Pipe Upset Parts",
        "abstract": "Washout failure on upset parts of the drill pipe caused serious damage to the drilling project,mainly due to upset of parts of the drill pipe design is unreasonable,or the existence of sharp corners,protrusions,so that the formation of vortex upset transition zone,resulting in drill pipe piercing.Defect detector drill upset parts of the measurement principle and structure are introduced to prevent defects in the provision of technical means to go down the drill pipe.",
        "keywords": [
            "drill pipe upset",
            "failure analysis",
            "detector",
            "drill pipe"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "CNPC Tubular Goods Research Institute,Xi'an ,China"
            },
            {
                "name": "GUO Fen-zhuan",
                "org": "Southwest Petroleum University,Chengdu ,China"
            },
            {
                "name": "WEI Dong",
                "org": "CNPC Tubular Goods Research Institute,Xi'an ,China"
            },
            {
                "name": "FENG Zhen-jun",
                "org": "CNPC Tubular Goods Research Institute,Xi'an ,China"
            },
            {
                "name": "YANG Li-neng",
                "org": "CNPC Tubular Goods Research Institute,Xi'an ,China"
            },
            {
                "name": "MA Yue-peng",
                "org": "CNPC Tubular Goods Research Institute,Xi'an ,China"
            }
        ],
        "venue": "Oil Field Equipment",
        "year": 2011
    },
    "xufROVdw": {
        "id": "xufROVdw",
        "title": "Effects of seepage threshold pressure gradient on areal sweep efficiency for five-spot pattern of low permeability reservoirs",
        "abstract": "The Areal sweep efficiency formula and water breakthrough time formula of considering the start-up pressure gradient are presented for the five-spot well pattern,which is by means of characteristics of five-spot water flooding exploitation in low-permeability reservoir and on the basis of stream tube model and the Beckley-Leverett equation.According to calculation and analysis results by actual oil production data,this theory solve the theoretical calculation problem of production well breakthrough time and areal sweep efficiency on the state of low-speed non-Darcy seepage flow different from Darcy seepage flow.This method can be used for quantitative characterization of reservoir produced degree in five-spot pattern and provide theory basis for development and evaluation of low-permeability reservoir.",
        "keywords": [
            "five-spot pattern",
            "seepage threshold pressure gradient",
            "low permeability reservoir",
            "water breakthrough time",
            "areal sweep efficiency"
        ],
        "authors": [
            {
                "name": "GUO Fen-zhuan",
                "org": "School of Petroleum Engineering,Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "TANG Hai",
                "org": "School of Petroleum Engineering,Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "LV Dong-liang",
                "org": "School of Petroleum Engineering,Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "CAO Feng",
                "org": "Tubular Goods Research of CNPC,Xi'an,Shanxi ,China"
            }
        ],
        "venue": "Journal of Daqing Petroleum Institute",
        "year": 2010
    },
    "bErXSBef": {
        "id": "bErXSBef",
        "title": "Effects of seepage threshold pressure gradient on areal sweep efficiency for 4-spot pattern of low permeability reservoir",
        "abstract": "According to the characteristics of the pattern water flooding exploitation in low-permeability reservoir,the stream tube model was constructed on the basis of 4-spot pattern flooding unit.Then,the areal sweep efficiency formula and water breakthrough time formula with consideration of the start-up pressure gradient were presented for the 4-spot pattern.The concept of non-sweep efficiency of 4-spot water flooding in low-permeability reservoir was put forward to characterize the ultimate undisplacement degree of 4-spot pattern in different injector producer distances and injector producer pressure differences.According to the calculation and analysis of actual oil production data,this theory solves the theoretical calculation problem of production well breakthrough time and areal sweep efficiency on the state of low-speed non-Darcy seepage flow different from Darcy seepage flow.This method provides theoretical foundation for the exploitation and evaluation of low-permeability reservoirs.",
        "keywords": [
            "low-permeability reservoir",
            "threshold pressure",
            "non-sweep efficiency",
            "water breakthrough time",
            "areal sweep efficiency",
            "4-spot pattern"
        ],
        "authors": [
            {
                "name": "GUO Fen-zhuan",
                "org": "School of Petroleum Engineering,Southwest Petroleum University,Chengdu,Sichuan,,China"
            },
            {
                "name": "TANG Hai",
                "org": "School of Petroleum Engineering,Southwest Petroleum University,Chengdu,Sichuan,,China"
            },
            {
                "name": "CAO Feng",
                "org": "Tubular Goods Research of CNPC,Xi'an,Shanxi ,China"
            },
            {
                "name": "ZHOU Ke",
                "org": "School of Petroleum Engineering,Southwest Petroleum University,Chengdu,Sichuan,,China"
            }
        ],
        "venue": "Journal of Daqing Petroleum Institute",
        "year": 2010
    },
    "zaGMaGjp": {
        "id": "zaGMaGjp",
        "title": "Development of the Study on the Oil Well Tubes",
        "abstract": "The status of the study about oil well tubes are generalized from three aspects like kinds,uses and problems of tubes.And then the discussion focuses on the problems existing in the study and production of oil well exploration & exploitation and oil well tubes,coupled with the development tendency in the future.At last,it is presented that there is a large gap between advanced countries and our country in the technical fields of high-end products,so it is necessary to speed up the localization of oil well tubes with high quality.",
        "keywords": [
            "expansion tubes",
            "coiled tubes",
            "oil well tubes",
            "drill string tubes"
        ],
        "authors": [
            {
                "name": "Feng Zhenjun",
                "org": ",et al"
            },
            {
                "name": "Cao Feng",
                "org": ",et al"
            },
            {
                "name": "Yang Lineng",
                "org": ",et al"
            }
        ],
        "venue": "Technology Supervision in Petroleum Industry",
        "year": 2010
    },
    "JAReUTzd": {
        "id": "JAReUTzd",
        "title": "Quality Control over High-Nickel Alloy Pipes",
        "abstract": "An introduction is given to the major production and inspection process at first. And then the analysis focuses on the problems easily appearing in the process of production and inspection. Based on the above analysis,some critical points of controlling the quality of this type of pipes are suggested at last.",
        "keywords": [
            "high-nickel alloy pipes",
            "quality control",
            "inspection procedure",
            "production procedure"
        ],
        "authors": [
            {
                "name": "Li liang",
                "org": ",et al"
            },
            {
                "name": "Li Jianai",
                "org": ",et al"
            },
            {
                "name": "Cao Feng",
                "org": ",et al"
            }
        ],
        "venue": "Technology Supervision in Petroleum Industry",
        "year": 2010
    },
    "LTBRYYnd": {
        "id": "LTBRYYnd",
        "title": "Calculation of water breakthrough time in non-Darcy seepage flow well pattern of low permeability reservoirs",
        "abstract": "The water breakthrough time formula of considering the startup pressure gradient is presented for the 4-spot,5-spot and invert 9-spot well patterns by means of characteristics of the pattern water flooding exploitation in low permeability reservoirs and on the basis of stream tube model,along with calculation and analysis results by actual oil production data.This method solves the theoretical calculation problem of production well breakthrough time in low-speed non-Darcy flow different from Darcy flow,which serves as the basis of water-flooding program design in low permeability reservoirs.",
        "keywords": [
            "seepage threshold pressure gradient",
            "pattern water flooding",
            "low permeability reservoir",
            "non-Darcy seepage flow",
            "water breakthrough time"
        ],
        "authors": [
            {
                "name": "GUO Fen-zhuan",
                "org": "Graduate School of Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "TANG Hai",
                "org": "Graduate School of Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "LV Dong-liang",
                "org": "Graduate School of Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "CAO Feng",
                "org": "Tubular Goods Institute of CNPC,Xi'an,Shanxi ,China"
            }
        ],
        "venue": "Journal of Daqing Petroleum Institute",
        "year": 2011
    },
    "9KiLD0e4": {
        "id": "9KiLD0e4",
        "title": "Research on rational formation pressure maintenance level in low permeability reservoir",
        "abstract": "A relational expression of non-dimensional fluid productivity index,water saturation and water cut has been derived by considering the influence factor of threshold pressure for low permeability reservoirs based on the fundamentals of petroleum engineering and relative permeability.The relationship between rational formation pressure and water cut as well as threshold pressure influence factor is established at different injection-production ratio for low permeability reservoirs.The calculation result of a field case indicates that under present injection-production ratio,good development response can be achieved by maintaining formation pressure at about 110%.The computed result is consistent with the actual oilfield result,demonstrating the feasibility of this theory and method,which are of guidance significance and practical value for analysis of water flooding technology and production rate for the development stage of low-to-moderate water cut.",
        "keywords": [
            "non-dimensional fluid productivity index",
            "injection-production ratio",
            "rational formation pressure",
            "low permeability reservoir",
            "threshold pressure influence factor"
        ],
        "authors": [
            {
                "name": "GUO Fen-zhuan",
                "org": "Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "TANG Hai",
                "org": "Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "LV Dong-liang",
                "org": "Southwest Petroleum University,Chengdu,Sichuan ,China"
            },
            {
                "name": "CAO Feng",
                "org": "Tubular Goods Research Institute of CNPC,Xi'an,Shaanxi ,China"
            },
            {
                "name": "BAI Yan",
                "org": "Changqing Oilfield Company,PetroChina,Yulin,Shaanxi ,China"
            }
        ],
        "venue": "Special Oil & Gas Reservoirs",
        "year": 2011
    },
    "yIJ07h13": {
        "id": "yIJ07h13",
        "title": "Discussions on the Preventative Measures of Drilling Rod Failure",
        "abstract": "Some concrete measures of preventing the failure of drilling rods are discussed from different angles like the design of drilling rod structure,the control of production quality and maintenance.It is suggested that defaults of technological design can be removed by optimizing the structure design of drilling rod;that quality of drilling rod can be controlled from the origin by means of executing mill supervision;and service period of drilling rod can be extended through the daily maintenance,periodic examination,and the establishment of drilling electronic records.",
        "keywords": [
            "electronic records",
            "failure analysis",
            "mill supervision",
            "drilling rod"
        ],
        "authors": [
            {
                "name": "Cao Feng",
                "org": ",et al"
            },
            {
                "name": "Wu Jianwen",
                "org": ",et al"
            },
            {
                "name": "Wei Dong",
                "org": ",et al"
            }
        ],
        "venue": "Technology Supervision in Petroleum Industry",
        "year": 2012
    },
    "tudW8XaP": {
        "id": "tudW8XaP",
        "title": "N-Type TaCoSn-Based Half-Heuslers as Promising Thermoelectric Materials.",
        "abstract": "Half-Heusler compounds are recognized as promising thermoelectric materials for high-temperature power generation, but their relatively high lattice thermal conductivity impedes further improvement of . Here, we report the synthesis of a new half-Heusler compound TaCoSn with a low thermal conductivity. Experimentally, the pristine TaCoSn exhibits a low lattice thermal conductivity of ~5.7 W m-1 K-1 at 300 K, which is lower than most of the other half-Heusler compounds. Phonon calculations by density functional theory indicate that the low phonon velocity, small Debye temperature, and large Grüneisen parameter are the contributors to the low thermal conductivity of TaCoSn. Importantly, intense point-defect scattering can be induced by alloying Nb at the Ta site, which further suppresses the thermal conductivity of TaCoSn. Additionally, Sb has been identified as an efficient dopant for supplying high electron concentration. Finally, the optimized n-type TaNbCoSnSb demonstrates a peak  above 0.7 at 973 K. Our work demonstrates that the TaCoSn-based half-Heuslers are promising thermoelectric materials.",
        "keywords": [
            "half-Heusler",
            "TaCoSn",
            "thermoelectric",
            "defects",
            "lattice thermal conductivity"
        ],
        "authors": [
            {
                "name": "Shan Li",
                "org": "Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, Guangdong 518055, P.R. China"
            },
            {
                "name": "Hangtian Zhu",
                "org": "Department of Physics and Texas Center for Superconductivity, University of Houston, Houston, Texas 77204, United States"
            },
            {
                "name": "Jun Mao",
                "org": "Department of Physics and Texas Center for Superconductivity, University of Houston, Houston, Texas 77204, United States"
            },
            {
                "name": "Zhenzhen Feng",
                "org": "Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, United States"
            },
            {
                "name": "Xiaofang Li",
                "org": "Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, Guangdong 518055, P.R. China"
            },
            {
                "name": "Chen Chen",
                "org": "Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, Guangdong 518055, P.R. China"
            },
            {
                "name": "Feng Cao",
                "org": "School of Science, Harbin Institute of Technology, Shenzhen, Guangdong 518055, P.R. China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, Guangdong 518055, P.R. China"
            },
            {
                "name": "David J Singh",
                "org": "Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, United States"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Department of Physics and Texas Center for Superconductivity, University of Houston, Houston, Texas 77204, United States"
            },
            {
                "name": "Qian Zhang",
                "org": "Department of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, Guangdong 518055, P.R. China"
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2019
    },
    "nNiYJIQf": {
        "id": "nNiYJIQf",
        "title": "Nanofluid of graphene-based amphiphilic Janus nanosheets for tertiary or enhanced oil recovery: High performance at low concentration",
        "abstract": "Abstract The current simple nanofluid flooding method for tertiary or enhanced oil recovery is inefficient, especially when used with low nanoparticle concentration. We have designed and produced a nanofluid of graphene-based amphiphilic nanosheets that is very effective at low concentration. Our nanosheets spontaneously approached the oil–water interface and reduced the interfacial tension in a saline environment (4 wt % NaCl and 1 wt % CaCl2), regardless of the solid surface wettability. A climbing film appeared and grew at moderate hydrodynamic condition to encapsulate the oil phase. With strong hydrodynamic power input, a solid-like interfacial film formed and was able to return to its original form even after being seriously disturbed. The film rapidly separated oil and water phases for slug-like oil displacement. The unique behavior of our nanosheet nanofluid tripled the best performance of conventional nanofluid flooding methods under similar conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Dan Luo",
                "org": "aDepartment of Physics and Texas Center for Superconductivity, University of Houston, Houston, TX 77204;"
            },
            {
                "name": "Dan Luo",
                "org": "aDepartment of Physics and Texas Center for Superconductivity, University of Houston, Houston, TX 77204;"
            },
            {
                "name": "Dan Luo",
                "org": "aDepartment of Physics and Texas Center for Superconductivity, University of Houston, Houston, TX 77204;"
            },
            {
                "name": "Feng Wang",
                "org": "University of Houston"
            },
            {
                "name": "Jingyi Zhu",
                "org": "cState Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, Sichuan 610500, China;"
            },
            {
                "name": "Feng Cao",
                "org": "University of Houston"
            },
            {
                "name": "Yuan Liu",
                "org": "University of Houston"
            },
            {
                "name": "Xiaogang Li",
                "org": "cState Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, Sichuan 610500, China;"
            },
            {
                "name": "Richard C. Willson",
                "org": "bDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204;"
            },
            {
                "name": "Richard C. Willson",
                "org": "bDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204;"
            },
            {
                "name": "Zhaozhong Yang",
                "org": "cState Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu, Sichuan 610500, China;"
            },
            {
                "name": "Ching-Wu Chu",
                "org": ""
            },
            {
                "name": "Ching-Wu Chu",
                "org": ""
            },
            {
                "name": "Zhifeng Ren",
                "org": "University of Houston"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2016
    },
    "E0mLbhlq": {
        "id": "E0mLbhlq",
        "title": "Gradient SiNO Anti-Reflective Layers in Solar Selective Coatings",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhifeng ren",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "tianyi sun",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "a3AjB9YD": {
        "id": "a3AjB9YD",
        "title": "Enhanced thermoelectric performance of p-ty pe Mg3Sb2 by lithium do ping and its tunability in an anionic framework",
        "abstract": "\nMg3Sb2-based Zintl compounds are considered as promising thermoelectric materials due to their low thermal conductivity and high Seebeck coefficient. In this paper, we studied the thermoelectric properties of p-type lithium (Li)-doped Mg3Sb2 prepared by ball milling and hot pressing. A maximum ZT value ~ 0.6 at about 773 K was achieved in Mg2.975Li0.025Sb2, which was ascribed to the increased carrier concentration by Li doping. Mixed scattering mechanism is dominated at lower temperature, yielding higher carrier mobility. Isoelectronic substitution of Zn on the Mg site further increased the electrical conductivity by narrowing the band gap and decreased the lattice thermal conductivity by double substitution, contributing to an enhanced average ZT in Mg2.475Zn0.5Li0.025Sb2.",
        "keywords": "",
        "authors": [
            {
                "name": "Chen Chen",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Xiaofang Li",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Shan Li",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Xinyu Wang",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Zongwei Zhang",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Jiehe Sui",
                "org": "State Key Laboratory of Advanced Welding and Joining,Harbin Institute of Technology,Harbin,China"
            },
            {
                "name": "Feng Cao",
                "org": "School of Science,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            },
            {
                "name": "Qian Zhang",
                "org": "Department of Materials Science and Engineering,Harbin Institute of Technology,Shenzhen,People’s Republic of China"
            }
        ],
        "venue": "Journal of Materials Science",
        "year": 2018
    },
    "burPxmUe": {
        "id": "burPxmUe",
        "title": "A broadband solar absorber with 12 nm thick ultrathin a-Si layer by using random metallic nanomeshes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tianyi sun",
                "org": ""
            },
            {
                "name": "chuan fei guo",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "eser metin akinoglu",
                "org": ""
            },
            {
                "name": "yang wang",
                "org": ""
            },
            {
                "name": "michael giersig",
                "org": ""
            },
            {
                "name": "zhifeng ren",
                "org": ""
            },
            {
                "name": "k kempa",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2014
    },
    "kmoxvZGL": {
        "id": "kmoxvZGL",
        "title": "Deep defect level engineering: A strategy of optimizing the carrier concentration for high thermoelectric performance",
        "abstract": "Thermoelectric properties are heavily dependent on the carrier concentration, and therefore the optimization of carrier concentration plays a central role in achieving high thermoelectric performance. The optimized carrier concentration is highly temperature-dependent and could even possibly vary within one order of magnitude in the temperature range of several hundreds of Kelvin. Practically, however, the traditional doping strategy will only lead to a constant carrier concentration, and thus the thermoelectric performance is only optimized within a limited temperature range. Here, we demonstrate that a temperature-dependent carrier concentration can be realized by simultaneously introducing shallow and deep defect levels. In this work, iodine (I) and indium (In) are co-doped in PbTe, where iodine acts as the shallow donor level that supplies sufficient electrons and indium builds up the localized half-filled deep defect state in the band gap. The indium deep defect state traps electrons at a lower temperature and the trapped electrons will be thermally activated back to the conduction band when the temperature rises. In this way, the carrier concentration can be engineered as temperature-dependent, which matches the theoretically predicted optimized carrier concentration over the whole temperature range. As a result, a room temperature ZT of similar to 0.4 and a peak ZT of similar to 1.4 at 773 K were obtained in the n-type In/I co-doped PbTe, leading to a record-high average ZT of similar to 1.04 in the temperature range of 300 to 773 K. Importantly, since deep defect levels also exist in other materials, the strategy of deep defect level engineering should be widely applicable to a variety of materials for enhancing the thermoelectric performance across a broad temperature range.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Qian",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Song Qichen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Wang Xinyu",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Sun Jingying",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Zhu Qing",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Dahal Keshab",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Lin Xi",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Cao Feng",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Zhou Jiawei",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Chen Shuo",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Chen Gang",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Mao Jun",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            }
        ],
        "venue": "ENERGY & ENVIRONMENTAL SCIENCE",
        "year": 2018
    },
    "cP1E8zZh": {
        "id": "cP1E8zZh",
        "title": "Heavy Doping by Bromine to Improve the Thermoelectric Properties of n-type Polycrystalline SnSe.",
        "abstract": "Single crystal tin selenide (SnSe) has attracted much attention for its excellent thermoelectric performance. However, polycrystalline SnSe exhibits unsatisfactory figure-of-merit due to the inferior electrical properties, especially for n-type SnSe. In this work, a high concentration of Br doping (6-12 atm%) on the Se site effectively increases the Hall carrier concentration from 1.6 x 10(17) cm(-3) (p-type) in undoped SnSe to 1.3 x 10(19) cm(-3) (n-type) in Br-doped SnSe0.88Br0.12, leading to an increased electrical conductivity close to that of a single crystal. Combined with the decreased lattice thermal conductivity due to the enhanced phonon scattering by composition fluctuation and dislocations, a peak ZT of approximate to 1.3 at 773 K, together with the enhanced average ZT is obtained in SnSe0.9Br0.1 along the hot pressing direction.",
        "keywords": [
            "carrier concentration",
            "highly doping",
            "n-type",
            "thermoelectric"
        ],
        "authors": [
            {
                "name": "Shan Li",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Yumei Wang",
                "org": "Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China"
            },
            {
                "name": "Chen Chen",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Xiaofang Li",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Wenhua Xue",
                "org": "Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China"
            },
            {
                "name": "Xinyu Wang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Zongwei Zhang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Jiehe Sui",
                "org": "Harbin Inst Technol, State Key Lab Adv Welding & Joining, Harbin 150001, Heilongjiang, Peoples R China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Qian Zhang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            }
        ],
        "venue": "ADVANCED SCIENCE",
        "year": 2018
    },
    "DH3kfQQy": {
        "id": "DH3kfQQy",
        "title": "Study of the Thermoelectric Properties of Lead Selenide Doped with Boron, Gallium, Indium, or Thallium",
        "abstract": "Group IIIA elements (B, Ga, In, and Tl) have been doped into PbSe for enhancement of thermoelectric properties. The electrical conductivity, Seebeck coefficient, and thermal conductivity were systematically studied. Room-temperature Hall measurements showed an effective increase in the electron concentration upon both Ga and In doping and the hole concentration upon Tl doping to similar to 7 x 10(19) cm(-3). No resonant doping phenomenon was observed when PbSe was doped with B, Ga, or In. The highest room-temperature power factor x 10(-3)W m(-1) K-2 was obtained for PbSe doped with 2 atom % B. However, the power factor in B-doped samples decreased with increasing temperature, opposite to the trend for the other dopants. A figure of merit (ZT) of similar to 1.2 at similar to 873 K was achieved in PbSe doped with 0.5 atom % Ga or In. With Tl doping, modification of the band structure around the Fermi level helped to increase the Seebeck coefficient, and the lattice thermal conductivity decreased, probably as a result of effective phonon scattering by both the heavy Tl3+ ions and the increased grain boundary density after ball milling. The highest p-type ZT value was similar to 1.0 at similar to 723 K.",
        "keywords": [],
        "authors": [
            {
                "name": "Qian Zhang",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Kevin Lukas",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Weishu Liu",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Keivan Esfarjani",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Cyril Opeil",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "David Broido",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "David Parker",
                "org": "Oak Ridge Natl Lab, Div Mat Sci & Technol, Oak Ridge, TN 37831 USA"
            },
            {
                "name": "David J Singh",
                "org": "Oak Ridge Natl Lab, Div Mat Sci & Technol, Oak Ridge, TN 37831 USA"
            },
            {
                "name": "Gang Chen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            }
        ],
        "venue": "JOURNAL OF THE AMERICAN CHEMICAL SOCIETY",
        "year": 2012
    },
    "2PNnv0jQ": {
        "id": "2PNnv0jQ",
        "title": "Studies on thermoelectric figure of merit of Na-doped p-type polycrystalline SnSe",
        "abstract": "SnSe has attracted some attention due to the recent report of record high thermoelectric figure-of-merit (ZT) of similar to 2.6 at about 923 K in single crystals. Even though the ZT is high in single crystal SnSe, it was very low in its polycrystalline form due to the very low electrical conductivity (<10(3) S m(-1)) from 300 K to 700 K. In this work, we report studies on enhancement of electrical conductivity by Na doping to optimize the carrier concentration in polycrystalline SnSe prepared by melting and hot pressing. A room temperature carrier concentration of similar to 2.7 x 10(19) cm(-3) was obtained in 2 atm% Na-doped SnSe samples with the highest power factor obtained in 1.5 atm% Na-doping. A peak ZT of similar to 0.8 was achieved at 773 K along the hot pressing direction and the average ZT was improved.",
        "keywords": [],
        "authors": [
            {
                "name": "eyob kebede chere",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Zhang Qian",
                "org": ""
            },
            {
                "name": "Dahal Keshab",
                "org": ""
            },
            {
                "name": "Cao Feng",
                "org": ""
            },
            {
                "name": "Mao Jun",
                "org": ""
            },
            {
                "name": "Ren Zhifeng",
                "org": ""
            }
        ],
        "venue": "JOURNAL OF MATERIALS CHEMISTRY A",
        "year": 2016
    },
    "GflQeiiE": {
        "id": "GflQeiiE",
        "title": "Concentrating solar thermoelectric generators with a peak efficiency of 7.4%",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Daniel Kraemer",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "Kenneth McEnaney",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "Lee A. Weinstein",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "James Loomis",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "Gang Chen",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "Qing Jie",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Weishu Liu",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            }
        ],
        "venue": "Nature Energy",
        "year": 2016
    },
    "AYgg0uF4": {
        "id": "AYgg0uF4",
        "title": "Enhancement of thermoelectric performance in n-type PbTe1-ySey by doping Cr and tuning Te:Se ratio",
        "abstract": "Lead telluride and its alloys have been extensively studied for medium temperature thermoelectric applications due to decent figure-of-merit (ZT) at temperature close to 900K. However, little emphasis has been given to improve the ZT near room temperature. In this investigation, we report a systematic study of Cr doping in PbTe1−ySey with y=0, 0.25, 0.5, 0.75, 0.85, and 1. We found the peak ZT temperature increased with increasing concentration of Se. The highest ZT of ~0.6 at room temperature in Te-rich Cr0.015Pb0.985Te0.75Se0.25 was obtained due to a lowered thermal conductivity and enhanced power factor resulted from high Seebeck coefficient of about −220µVK−1 and high Hall mobility ~1120cm2V−1s−1 at room temperature. A room temperature ZT of ~0.5 and peak ZT of ~1 at about 573–673K is shown by Se-rich sample Cr0.01Pb0.99Te0.25Se0.75. This improvement of the room temperature ZT improved the average ZT over a wide temperature range and could potentially lead to a single leg efficiency of thermoelectric conversion for Te-rich Cr0.015Pb0.985Te0.75Se0.25 up to ~11% and Se-rich Cr0.01Pb0.99Te0.25Se0.75 up to ~13% with cold side and hot side temperature at 300K and 873K, respectively, if matched with appropriate p-type legs.",
        "keywords": [
            "Thermoelectric",
            "Cr doping",
            "Te:Se ratio",
            "Average ZT",
            "Efficiency"
        ],
        "authors": [
            {
                "name": "eyob kebede chere",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Zhang Qian",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "McEnaney Kenneth",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"
            },
            {
                "name": "Yao Mengliang",
                "org": "Department of Physics, Boston College, Chestnut Hill, MA 02467, USA"
            },
            {
                "name": "Cao Feng",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Sun Jingying",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Chen Shuo",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "cyril p opeil",
                "org": "Department of Physics, Boston College, Chestnut Hill, MA 02467, USA"
            },
            {
                "name": "Chen Gang",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            }
        ],
        "venue": "Nano Energy",
        "year": 2015
    },
    "vyzRwins": {
        "id": "vyzRwins",
        "title": "High performance mid-temperature selective absorber based on titanium oxides cermet deposited by direct current reactive sputtering of a single titanium target",
        "abstract": "This article reports the design and fabrication of a new double cermet-based low-mid temperature solar selective absorber based on TiOx cermet layers, which were deposited with a single Ti target by varying O2 partial pressure in sputtering chamber as reactive gas. High metal volume fraction cermet 1 and low metal volume fraction cermet 2 were deposited with O2 partial pressure of 0.15 mTorr and 0.25 mTorr, respectively, with direct current power density of 6.58 W cm−2. The complex refractive indices from ellipsometry were used to design solar selective absorber. The reflectance, thermal stability, and morphology were studied in absorbers on Cu and stainless steel. The effect of TiO2 and SiO2 as anti-reflective coating layers was investigated. The absorber on Cu substrate has high absorptance of 90.8% and low emittance of 4.9% (100 °C), and changed to 96.0% and 6.6%, respectively, after annealing at 300 °C for 4 days.",
        "keywords": "",
        "authors": [
            {
                "name": "Lu Tang",
                "org": "#N#Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Feng Cao",
                "org": "#N#Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Yang Li",
                "org": "#N#Department of Electrical and Computer Engineering, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Jiming Bao",
                "org": "#N#Department of Electrical and Computer Engineering, University of Houston, Houston, Texas 77204, USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "#N#Department of Physics and TcSUH, University of Houston, Houston, Texas 77204, USA"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2016
    },
    "YxUqPyHW": {
        "id": "YxUqPyHW",
        "title": "Balancing the anionic framework polarity for enhanced thermoelectric performance in YbMg2Sb2 Zintl compounds",
        "abstract": "1-2-2-type Zintl phase compound has aroused great interest for potential thermoelectric applications. However, YbMg2Sb2 is seldom studied due to the very low electrical conductivity resulting from the large difference in the electronegativity between Mg and Sb. In this paper, we adjust the covalently bonded network of MgSb by replacing part of the Mg with Zn which has the electronegativity closer to that of Sb. The decreased polarity in the anionic framework offers more free distance for electrons for the enhanced Hall mobility and electrical conductivity. Together with the increased point defect and the decreased lattice thermal conductivity by introduction of Zn, the maximum ZT value of ∼0.8 at 773 K is achieved in YbMg0.9Zn1.1Sb2 which is ∼100% enhancement compared with that of YbMg2Sb2.",
        "keywords": [
            "Thermoelectric",
            "Zintl phase",
            "YbMg2Sb2",
            "Polarity",
            "Electronegativity"
        ],
        "authors": [
            {
                "name": "Zongwei Zhang",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Xinyu Wang",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Yijie Liu",
                "org": "School of Science, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Chen Chen",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Honghao Yao",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Li Yin",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Xiaofang Li",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Shan Li",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Fan Zhang",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Fengxian Bai",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Jiehe Sui",
                "org": "State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, China"
            },
            {
                "name": "Bo Yu",
                "org": "Ningbo Fengcheng Advanced Energy Materials Research Institute, Fenghua District, Ningbo, Zhejiang, 315500, China"
            },
            {
                "name": "Feng Cao",
                "org": "School of Science, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Jun Mao",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX, 77204, USA"
            },
            {
                "name": "Guoqiang Xie",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            },
            {
                "name": "Qian Zhang",
                "org": "Department of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, China"
            }
        ],
        "venue": "Journal of Materiomics",
        "year": 2019
    },
    "jAbMxjDQ": {
        "id": "jAbMxjDQ",
        "title": "A high-temperature stable spectrally-selective solar absorber based on cermet of titanium nitride in SiO2 deposited on lanthanum aluminate",
        "abstract": "Spectrally-selective solar absorber is required to be thermally stable at high operational temperature. However the currently available absorbers aren't stable beyond 700 degrees C. Here we explore a new absorber with cermet of TiN in SiO2 on LaAlO3 substrate that can be used for long term at 700 degrees C. The optimized cermets contain TiN with volume fraction of 60% and 65% as sun-light absorption media, SiO2 as anti-reflection coating (ARC), and tungsten (W) as infrared (IR) reflection layer. The absorbers demonstrate an absorptance higher than similar to 95% before annealing and similar to 94% after annealing at 700 degrees C, which will be useful for especially concentrated solar applications.",
        "keywords": [
            "Solar absorber",
            "Cermet",
            "Solar absorptance",
            "Thermal eminence",
            "Spectral selectivity"
        ],
        "authors": [
            {
                "name": "Cao Feng",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Guangdong, Peoples R China; Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Tang Lu",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Li Yang",
                "org": "Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA"
            },
            {
                "name": "Litvinchuk, Alexander P.",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Bao Jiming",
                "org": "Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, TcSUH, Houston, TX 77204 USA"
            }
        ],
        "venue": "SOLAR ENERGY MATERIALS AND SOLAR CELLS",
        "year": 2017
    },
    "X0y3Cvhb": {
        "id": "X0y3Cvhb",
        "title": "Zintl-phase Eu2ZnSb2: A promising thermoelectric material with ultralow thermal conductivity",
        "abstract": "Zintl compounds are considered to be potential thermoelectric materials due to their \"phonon glass electron crystal\" (PGEC) structure. A promising Zintl-phase thermoelectric material, 2-1-2-type Eu2ZnSb2 (P6(3)/mmc), was prepared and investigated. The extremely low lattice thermal conductivity is attributed to the external Eu atomic layers inserted in the [Zn2Sb2](2-) network in the structure of 1-2-2-type EuZn2Sb2 (P (3) over bar m1), as well as the abundant inversion domain boundary. By regulating the Zn deficiency, the electrical properties are significantly enhanced, and the maximum ZT value reaches similar to 1.0 at 823 K for Eu2Zn0.98Sb2. Our discovery provides a class of Zintl thermoelectric materials applicable in the medium-temperature range.",
        "keywords": [
            "thermoelectric properties",
            "Zintl phase",
            "low thermal conductivity",
            "Eu2ZnSb2"
        ],
        "authors": [
            {
                "name": "Chen Chen",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Xue Wenhua",
                "org": "Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China"
            },
            {
                "name": "Li Shan",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Zhang Zongwei",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Li Xiaofang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wang Xinyu",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Liu Yijie",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Sui Jiehe",
                "org": "Harbin Inst Technol, State Key Lab Adv Welding & Joining, Harbin 150001, Heilongjiang, Peoples R China"
            },
            {
                "name": "Liu Xingjun",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China; Harbin Inst Technol, State Key Lab Adv Welding & Joining, Harbin 150001, Heilongjiang, Peoples R China"
            },
            {
                "name": "Cao Feng",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, Texas Ctr Superconduct, Houston, TX 77204 USA"
            },
            {
                "name": "Chu Ching-Wu",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA; Univ Houston, Texas Ctr Superconduct, Houston, TX 77204 USA"
            },
            {
                "name": "Wang Yumei",
                "org": "Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China"
            },
            {
                "name": "Zhang Qian",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China; Harbin Inst Technol, Inst Mat Genome & Big Data, Shenzhen 518055, Peoples R China"
            }
        ],
        "venue": "PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA",
        "year": 2019
    },
    "w6Iw4DsO": {
        "id": "w6Iw4DsO",
        "title": "Study of the Thermoelectric Properties of Lead Selenide Doped with Boron, Gallium, Indium, or Thallium",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "kevin lukas",
                "org": ""
            },
            {
                "name": "weishu liu",
                "org": ""
            },
            {
                "name": "keivan esfarjani",
                "org": ""
            },
            {
                "name": "cyril p opeil",
                "org": ""
            },
            {
                "name": "david broido",
                "org": ""
            },
            {
                "name": "david parker",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            },
            {
                "name": "zhifeng ren",
                "org": ""
            },
            {
                "name": "david j singh",
                "org": ""
            },
            {
                "name": "qian zhang",
                "org": ""
            }
        ],
        "venue": "Journal of the American Chemical Society",
        "year": 2012
    },
    "28wilSHJ": {
        "id": "28wilSHJ",
        "title": "Heavy doping and band engineering by potassium to improve the thermoelectric figure of merit in p-type PbTe, PbSe, and PbTe(1-y)Se(y).",
        "abstract": "We present detailed studies of potassium doping in PbTe1-ySey (y = 0, 0.15, 0.25, 0.75, 0.85, 0.95, and 1). It was found that Se increases the doping concentration of K in PbTe as a result of the balance of electronegativity and also lowers the lattice thermal conductivity because of the increased number of point defects. Tuning the composition and carrier concentration to increase the density of states around the Fermi level results in higher Seebeck coefficients for the two valence bands of PbTe1-ySey. Peak thermoelectric figure of merit (ZT) values of similar to 1.6 and similar to 1.7 were obtained for Te-rich K0.02Pb0.98Te0.75Se0.25 us at 773 K and Se-rich K0.02Pb0.98Te0.15Se0.85 at 873 K, respectively. However, the average ZT was higher in Te-rich compositions than in Se-rich compositions, with the best found in K0.02Pb0.98Te0.75Se0.25. Such a result is due to the improved electron transport afforded by heavy K doping with the assistance of Se.",
        "keywords": [],
        "authors": [
            {
                "name": "Qian Zhang",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Weishu Liu",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Kevin Lukas",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Bo Yu",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Shuo Chen",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Cyril Opeil",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "David Broido",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Gang Chen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            }
        ],
        "venue": "JOURNAL OF THE AMERICAN CHEMICAL SOCIETY",
        "year": 2012
    },
    "fzlgfTLw": {
        "id": "fzlgfTLw",
        "title": "Metallic nanostructures for light trapping in energy-harvesting devices",
        "abstract": "Solar energy is abundant and environmentally friendly. Light trapping in solar-energy-harvesting devices or structures is of critical importance. This article reviews light trapping with metallic nanostructures for thin film solar cells and selective solar absorbers. The metallic nanostructures can either be used in reducing material thickness and device cost or in improving light absorbance and thereby improving conversion efficiency. The metallic nanostructures can contribute to light trapping by scattering and increasing the path length of light, by generating strong electromagnetic field in the active layer, or by multiple reflections/absorptions. We have also discussed the adverse effect of metallic nanostructures and how to solve these problems and take full advantage of the light-trapping effect.",
        "keywords": [
            "conversion efficiency",
            "light trapping",
            "photovoltaics",
            "plasmonics",
            "solar absorber"
        ],
        "authors": [
            {
                "name": "Chuan Fei Guo",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Tianyi Sun",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Qian Liu",
                "org": "Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            }
        ],
        "venue": "LIGHT-SCIENCE & APPLICATIONS",
        "year": 2014
    },
    "Nt1jOui0": {
        "id": "Nt1jOui0",
        "title": "Manipulating the intrinsic vacancies for enhanced thermoelectric performance in Eu2ZnSb2 Zintl phase",
        "abstract": "Zintl compounds have caught great attention in thermoelectric applications due to their intrinsic “electron-crystal, phonon-glass” structures. Previous studies suggested that Zintl-phase Eu2ZnSb2 was a promising thermoelectric material due to its ultralow thermal conductivity. In this work, we used Ag to regulate the Zn–Sb framework for enhanced electrical properties, and prepared Eu2Zn1-0.5xAgxSb2 (x = 0.02, 0.06, and 0.1) by ball milling and spark plasma sintering. The additional Ag fills the initial vacancies and causes both increased carrier concentration and mobility. The maximum ZT reaches ~0.92 at 823 K for Eu2Zn0.97Ag0.06Sb2. By further reducing the Zn content, the carrier concentration increases close to the optimum value, and a peak ZT value of ~1.1 at 823 K was achieved for Eu2Zn0.95Ag0.06Sb2.",
        "keywords": [
            "Thermoelectric",
            "Zintl phase",
            "Eu2ZnSb2",
            "Carrier mobility",
            "Intrinsic vacancies"
        ],
        "authors": [
            {
                "name": "Chen Chen",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Xiaofang Li",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Wenhua Xue",
                "org": "Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Science, Beijing, 100190, PR China"
            },
            {
                "name": "Fengxian Bai",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Yifang Huang",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Honghao Yao",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Shan Li",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Zongwei Zhang",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Xinyu Wang",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Jiehe Sui",
                "org": "State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin, 150001, PR China"
            },
            {
                "name": "Xingjun Liu",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Feng Cao",
                "org": "School of Science, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            },
            {
                "name": "Yumei Wang",
                "org": "Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Science, Beijing, 100190, PR China"
            },
            {
                "name": "Qian Zhang",
                "org": "School of Materials Science and Engineering, Institute of Materials Genome & Big Data, Harbin Institute of Technology, Shenzhen, 518055, PR China"
            }
        ],
        "venue": "Nano Energy",
        "year": 2020
    },
    "sgYZ6xJB": {
        "id": "sgYZ6xJB",
        "title": "Tuning the shape and thermoelectric property of PbTe nanocrystals by bismuth doping.",
        "abstract": "We report the synthesis of a series of monodispersed Bi-doped PbTe nanocrystals with tunable morphologies by using a doping precursor of bismuth(III) 2-ethylhexanoate. The as-synthesized Pb(1-x)Bi(x)Te (x = 0.005, 0.010, 0.015, 0.020) nanocrystals are characterized by X-ray diffraction, X-ray photoelectron spectroscopy and Hall measurements. The nanocrystals with controlled spherical, cuboctahedral, and cubic shapes were readily prepared by varying the Bi doping concentration. Thermoelectric investigation of these nanocrystals shows that the Bi(3+) doping increases electrical conductivity from 350 to 650 K and changes the Seebeck coefficient sign from positive to negative.",
        "keywords": [
            "electric conductivity",
            "x ray diffraction",
            "x ray photoelectron spectroscopy"
        ],
        "authors": [
            {
                "name": "Qian Zhang",
                "org": ""
            },
            {
                "name": "Ting Sun",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Ming Li",
                "org": ""
            },
            {
                "name": "Minghui Hong",
                "org": ""
            },
            {
                "name": "Jikang Yuan",
                "org": ""
            },
            {
                "name": "Qingyu Yan",
                "org": ""
            },
            {
                "name": "Huey Hoon Hng",
                "org": ""
            },
            {
                "name": "Nianqiang Wu",
                "org": ""
            },
            {
                "name": "Xiaogang Liu",
                "org": ""
            }
        ],
        "venue": "Nanoscale",
        "year": 2010
    },
    "c0vxlZpx": {
        "id": "c0vxlZpx",
        "title": "Heavy Doping and Band Engineering by Potassium to Improve the Thermoelectric Figure of Merit in p-Type PbTe, PbSe, and PbTe[subscript 1– y]Se[subscript y]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qian zhang",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "weishu liu",
                "org": ""
            },
            {
                "name": "kevin lukas",
                "org": ""
            },
            {
                "name": "bo yu",
                "org": ""
            },
            {
                "name": "shuo chen",
                "org": ""
            },
            {
                "name": "cyril p opeil",
                "org": ""
            },
            {
                "name": "david broido",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            },
            {
                "name": "zhifeng ren",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "Zllk0fmB": {
        "id": "Zllk0fmB",
        "title": "Heavy Doping and Band Engineering by Potassium to Improve the Thermoelectric Figure of Merit in p-Type PbTe, PbSe, and PbTe1-ySey",
        "abstract": "We present detailed studies of potassium doping in PbTe1-ySey (y = 0, 0.15, 0.25, 0.75, 0.85, 0.95, and 1). It was found that Se increases the doping concentration of K in PbTe as a result of the balance of electronegativity and also lowers the lattice thermal conductivity because of the increased number of point defects. Tuning the composition and carrier concentration to increase the density of states around the Fermi level results in higher Seebeck coefficients for the two valence bands of PbTe1-ySey. Peak thermoelectric figure of merit (ZT) values of similar to 1.6 and similar to 1.7 were obtained for Te-rich K0.02Pb0.98Te0.75Se0.25 us at 773 K and Se-rich K0.02Pb0.98Te0.15Se0.85 at 873 K, respectively. However, the average ZT was higher in Te-rich compositions than in Se-rich compositions, with the best found in K0.02Pb0.98Te0.75Se0.25. Such a result is due to the improved electron transport afforded by heavy K doping with the assistance of Se.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Qian",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Cao Feng",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Liu Weishu",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Lukas Kevin",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Yu Bo",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Chen Shuo",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "cyril p opeil",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Broido David",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Chen Gang",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            }
        ],
        "venue": "JOURNAL OF THE AMERICAN CHEMICAL SOCIETY",
        "year": 2012
    },
    "zCTIIs32": {
        "id": "zCTIIs32",
        "title": "Enhancement of Thermoelectric Performance of n-Type PbSe by Cr Doping with Optimized Carrier Concentration",
        "abstract": "Ti, V, Cr, Nb, and Mo are found to be effective at increasing the Seebeck coefficient and power factor of n-type PbSe at temperatures below 600 K. It is found that the higher Seebeck coefficients and power factors are due to higher Hall mobility approximate to 1000 cm(2) V-1 s(-1) at lower carrier concentration. A larger average ZT value (relevant for applications) can be obtained by an optimization of carrier concentration to approximate to 10(18)-10(19) cm(-3). Even though the highest room temperature power factor approximate to 3.3 x 10(-3) W m(-1) K-2 is found in 1 at% Mo-doped PbSe, the highest ZT is achieved in Cr-doped PbSe. Combined with the lower thermal conductivity, ZT is improved to approximate to 0.4 at room temperature and peak ZTs of approximate to 1.0 are observed at approximate to 573 K for Pb0.9925Cr0.0075Se and approximate to 673 K for Pb0.995Cr0.005Se. The calculated device efficiency of Pb0.995Cr0.005Se is as high as approximate to 12.5% with cold side 300 K and hot side 873 K, higher than those of all the n-type PbSe materials reported in the literature.",
        "keywords": [],
        "authors": [
            {
                "name": "Qian Zhang",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Eyob Kebede Chere",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Kenneth McEnaney",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Mengliang Yao",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Yizhou Ni",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Shuo Chen",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Cyril Opeil",
                "org": "Boston Coll, Dept Phys, Chestnut Hill, MA 02467 USA"
            },
            {
                "name": "Gang Chen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            }
        ],
        "venue": "ADVANCED ENERGY MATERIALS",
        "year": 2015
    },
    "nWkXEP8Z": {
        "id": "nWkXEP8Z",
        "title": "A high-performance spectrally-selective solar absorber based on a yttria-stabilized zirconia cermet with high-temperature stability",
        "abstract": "Spectrally-selective solar absorbers are widely used in solar hot water and concentrating solar power (CSP) systems. However, their performance at high temperatures (>450 degrees C) is still not satisfactory due to high infrared (IR) emittance and lack of long-term thermal stability. Here, we explore yttria-stabilized zirconia (YSZ) cermet-based spectrally-selective surfaces for high-temperature solar absorber applications. The developed multilayer selective surface comprises two sunlight-absorbing W-Ni-YSZ cermet layers with different W-Ni volume fractions inside the YSZ matrix, two anti-reflection coatings (ARCs), and one tungsten IR reflection layer for reduced IR emittance and improved thermal stability, deposited on a polished stainless steel (SS) substrate. The fabricated solar absorbers are tested for their long-term thermal stability at 600 degrees C. We find a distinct change in the surface morphology of the solar absorbers when oxygen is highly deficient in the YSZ-ARC layers. The oxygen deficiency can be effectively overcome through increasing the oxygen partial pressure during sputtering, which leads to a stable solar absorber with a solar absorptance of similar to 0.91 and a total hemispherical emittance of similar to 0.13 at 500 degrees C. Those values are obtained at the actual operating temperature using an absolute and direct method that measures the total hemispherical emittance with high accuracy. In contrast, most reports on solar absorber development in the literature to date use only near room-temperature spectroscopy techniques that have been shown to significantly underestimate the total hemispherical emittance. This makes our experimentally demonstrated total hemispherical emittance value the lowest ever reported for a high-temperature stable solar absorber with solar absorptance above 0.9.",
        "keywords": [],
        "authors": [
            {
                "name": "feng cao",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "daniel kraemer",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "lu tang",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "yang li",
                "org": "Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA"
            },
            {
                "name": "a p litvinchuk",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "jiming bao",
                "org": "Univ Houston, Dept Elect & Comp Engn, Houston, TX 77204 USA"
            },
            {
                "name": "gang chen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "zhifeng ren",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            }
        ],
        "venue": "ENERGY & ENVIRONMENTAL SCIENCE",
        "year": 2015
    },
    "2H1UcTkk": {
        "id": "2H1UcTkk",
        "title": "High thermoelectric performance of n-type PbTe1-ySy due to deep lying states induced by indium doping and spinodal decomposition",
        "abstract": "Good thermoelectric materials should have high engineering figure-of-merit (ZT)eng, not peak ZT, to achieve high conversion efficiency. In this work, we achieved a good (ZT)eng by optimizing the carrier concentration to improve the room temperature ZT using deep lying dopant, indium, in PbTe1−ySy. It was found that a room temperature ZT as high as ~0.5 and a peak ZT ~1.1 at about 673K were obtained in Pb0.98In0.02Te0.8S0.2 due to a lower thermal conductivity by alloy scattering and Spinodal decomposition. The calculated efficiency could be as high as ~12% at cold side 323K and hot side 773K. The approach is expected to work in other materials systems too.",
        "keywords": [
            "Thermoelectrics",
            "Deep lying doping",
            "Spinodal decomposition",
            "Conversion efficiency"
        ],
        "authors": [
            {
                "name": "Zhang Qian",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Chere Eyob Kebede",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Wang Yumei",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Kim Hee Seok",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "He Ran",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Cao Feng",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Dahal Keshab",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            },
            {
                "name": "Broido David",
                "org": "Department of Physics, Boston College, Chestnut Hill, MA 02467, USA"
            },
            {
                "name": "Chen Gang",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Department of Physics and TcSUH, University of Houston, Houston, TX 77204, USA"
            }
        ],
        "venue": "Nano Energy",
        "year": 2016
    },
    "1JIfqYB0": {
        "id": "1JIfqYB0",
        "title": "Increased thermoelectric performance by Cl doping in nanostructured AgPb18SbSe20-xClx",
        "abstract": "The quaternary AgPb18SbTe20 (LAST) alloy is well known for having low thermal conductivity and high ZT. Nano-precipitates of AgSbTe2 contribute significantly to the decrease of the lattice thermal conductivity. In this work, Te was completely substituted by the more economically available Se in LAST. Low thermal conductivity was achieved in AgPb18SbSe20 (LASS) made by melting and hot pressing. We subsequently studied the thermoelectric properties of LASS with different dopants, and found Cl was effective in increasing the carrier concentration and power factor, which enhanced ZT to ~1.3 in n-type AgPb18SbSe19.928Cl0.072 at about 873K.",
        "keywords": [
            "Thermoelectrics",
            "AgPb18SbSe20",
            "Cl doping",
            "Nanoregions"
        ],
        "authors": [
            {
                "name": "Zhang Qian",
                "org": "Department of Physics, University of Houston and TcSUH, Houston, TX 77204, USA"
            },
            {
                "name": "Lan Yucheng",
                "org": "Department of Physics, University of Houston and TcSUH, Houston, TX 77204, USA"
            },
            {
                "name": "Yang Silong",
                "org": "McGill University, Montreal, PQ, Canada H3A 0G4"
            },
            {
                "name": "Cao Feng",
                "org": "Department of Physics, University of Houston and TcSUH, Houston, TX 77204, USA"
            },
            {
                "name": "Yao Mengliang",
                "org": "Department of Physics, Boston College, Chestnut Hill, MA 02467, USA"
            },
            {
                "name": "Opeil Cyril",
                "org": "Department of Physics, Boston College, Chestnut Hill, MA 02467, USA"
            },
            {
                "name": "Broido David",
                "org": "Department of Physics, Boston College, Chestnut Hill, MA 02467, USA"
            },
            {
                "name": "Chen Gang",
                "org": "Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"
            },
            {
                "name": "Ren Zhifeng",
                "org": "Department of Physics, University of Houston and TcSUH, Houston, TX 77204, USA"
            }
        ],
        "venue": "Nano Energy",
        "year": 2013
    },
    "6IikPFAH": {
        "id": "6IikPFAH",
        "title": "Enhanced Thermoelectric Performance of Zintl Phase Ca9Zn4+xSb9 by Beneficial Disorder on the Selective Cationic Site.",
        "abstract": "Zintl phase compounds Ca9Zn4+xSb9 have promising thermoelectric properties due to the complex crystal structure and the tunable interstitial Zn. In this work, we prepared nominal Ca9Zn4+xSb9 (x = 0.5, 0.6, 0.7, and 0.8) using ball milling and hot pressing. Further decreased lattice thermal conductivity was obtained by isoelectronic substitution of Eu on the selective Ca site, which is farther away from the framework of [Zn4+xSb9]- for the less disturbance of carrier transport. Together with the intensively enhanced carrier mobility, which is attributed to the decreased effective mass and the increased interstitial Zn by inclusion of Eu, an increased peak ZT value to ~1.05 at 773 K and an enhanced average ZT value to ~0.73 from 300 K to 823 K were achieved in Ca6.75Eu2.25Zn4.7Sb9.",
        "keywords": [
            "thermoelectric",
            "Zintl phase",
            "Ca9Zn4+xSb9",
            "mobility",
            "thermal conductivity"
        ],
        "authors": [
            {
                "name": "Chen Chen",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wenhua Xue",
                "org": "Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan 030024, Shanxi, Peoples R China"
            },
            {
                "name": "Xiaofang Li",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Yucheng Lan",
                "org": "Morgan State Univ, Dept Phys & Engn Phys, Baltimore, MD 21254 USA"
            },
            {
                "name": "Zongwei Zhang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Xinyu Wang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Fan Zhang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Honghao Yao",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Shan Li",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiehe Sui",
                "org": "Harbin Inst Technol, State Key Lab Adv Welding & Joining, Harbin 150001, Heilongjiang, Peoples R China"
            },
            {
                "name": "Peide Han",
                "org": "Taiyuan Univ Technol, Minist Educ, Key Lab Interface Sci & Engn Adv Mat, Taiyuan 030024, Shanxi, Peoples R China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Yumei Wang",
                "org": "Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Inst Phys, Beijing 100190, Peoples R China"
            },
            {
                "name": "Qian Zhang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China"
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2019
    },
    "dUncK4BO": {
        "id": "dUncK4BO",
        "title": "Defect engineering for realizing p-type AgBiSe2 with promising thermoelectric performance",
        "abstract": "Realization of ambipolar doping (n- and p-type) in thermoelectric materials is highly critical for module design. However, many thermoelectric materials can only be doped into one type, due to the Fermi-level pinning by intrinsic defects, or have poor performance for one doping type. AgBiSe2 is a typical case that shows persistent n-type doping while p-type AgBiSe2 has been predicted to exhibit higher thermoelectric performance but has not been reliably obtained nor has the performance been demonstrated. Here, we demonstrate the successful experimental synthesis of p-type AgBiSe2 by suppressing Se vacancies via adding an excess amount of Se. In addition, we show that Pb doping at the Bi site can effectively increase the hole concentration and optimize the power factor of p-type AgBiSe2. This leads to promising thermoelectric performance close to room temperature. Our work demonstrates the importance of defect engineering for overcoming the doping bottleneck, thus promoting the discovery of new thermoelectric materials.",
        "keywords": "",
        "authors": [
            {
                "name": "Shan Li",
                "org": "Univ Houston, Dept Phys, Univ Houston TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Zhenzhen Feng",
                "org": "Univ Missouri, Dept Phys & Astron, Columbia, MO 65211 USA"
            },
            {
                "name": "Zhongjia Tang",
                "org": "Univ Houston, Dept Chem, Houston, TX 77204 USA"
            },
            {
                "name": "Fanghao Zhang",
                "org": "Univ Houston, Dept Phys, Univ Houston TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Harbin Inst Technol, Sch Sci, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Harbin Inst Technol, Sch Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "David J. Singh",
                "org": "Univ Missouri, Dept Phys & Astron, Columbia, MO 65211 USA"
            },
            {
                "name": "Jun Mao",
                "org": "Univ Houston, Dept Phys, Univ Houston TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Univ Houston, Dept Phys, Univ Houston TcSUH, Houston, TX 77204 USA"
            },
            {
                "name": "Qian Zhang",
                "org": "Harbin Inst Technol, Sch Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            }
        ],
        "venue": "CHEMISTRY OF MATERIALS",
        "year": 2020
    },
    "WCQrsOUH": {
        "id": "WCQrsOUH",
        "title": "Enhanced Thermal Stability of W‐Ni‐Al2O3 Cermet‐Based Spectrally Selective Solar Absorbers with Tungsten Infrared Reflectors",
        "abstract": "Solar thermal technologies such as solar hot water and concentrated solar power trough systems rely on spectrally selective solar absorbers. These solar absorbers are designed to efficiently absorb the sunlight while suppressing re-emission of infrared radiation at elevated temperatures. Efforts for the development of such solar absorbers must not only be devoted to their spectral selectivity but also to their thermal stability for high temperature applications. Here, selective solar absorbers based on two cermet layers are fabricated on mechanically polished stainless steel substrates using a magnetron sputtering technique. The targeted operating temperature is 500-600 degrees C. A detrimental change in the morphology, phase, and optical properties is observed if the cermet layers are deposited on a stainless steel substrate with a thin nickel adhesion layer, which is due to the diffusion of iron atoms from the stainless steel into the cermet layer forming a FeWO4 phase. In order to improve thermal stability and reduce the infrared emittance, tungsten is found to be a good candidate for the infrared reflector layer due to its excellent thermal stability and low infrared emittance. A stable solar absorptance of approximate to 0.90 is demonstrated, with a total hemispherical emittance of 0.15 at 500 degrees C.",
        "keywords": [
            "solar absorbers",
            "cermet",
            "solar absorptance",
            "thermal emittance",
            "spectral selectivity"
        ],
        "authors": [
            {
                "name": "feng cao",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "daniel kraemer",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "tianyi sun",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "yucheng lan",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "gang chen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "zhifeng ren",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            }
        ],
        "venue": "ADVANCED ENERGY MATERIALS",
        "year": 2015
    },
    "7tasmwmB": {
        "id": "7tasmwmB",
        "title": "Toward versatile applications via tuning transition wavelength of the WTa-SiO2 based spectrally selective absorber",
        "abstract": "Controlling solar spectra via the careful design could realize the optimized utilization of energy. Especially for spectrally selective solar absorbers, achieving the appropriate transition wavelength can boom conversion efficiency for a certain application under the consideration of cost. Here, we experimentally demonstrated a kind of WTa-SiO2 cermet based absorbers with transition wavelength of around 1500 nm, 2000 nm, and 2500 nm, which can meet the versatile applications under the conditions of different operating temperatures and different optical concentrations. All the absorbers possess a promising solar absorptance of above 95% and photothermal efficiency of above 91% at 82 degrees C with 1 sun, as well as the superior thermal stability at 600 degrees C due to the formation of tantalum oxide in WTa-SiO2 cermet in the annealing process.",
        "keywords": [
            "Spectrally selective absorber",
            "WTa alloy",
            "Quasi-optical microcavity",
            "Thermal stability"
        ],
        "authors": [
            {
                "name": "Zuoxu Wu",
                "org": "Minist Ind & Informat Technol, Key Lab Micronano Optoelect Informat Syst, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Wenhua Xue",
                "org": "Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter, Beijing 100190, Peoples R China"
            },
            {
                "name": "Yijie Liu",
                "org": "Minist Ind & Informat Technol, Key Lab Micronano Optoelect Informat Syst, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Dong Wei",
                "org": "Minist Ind & Informat Technol, Key Lab Micronano Optoelect Informat Syst, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Jian Wang",
                "org": "Minist Ind & Informat Technol, Key Lab Micronano Optoelect Informat Syst, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Li Yin",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Yumei Wang",
                "org": "Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter, Beijing 100190, Peoples R China"
            },
            {
                "name": "Xingjun Liu",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Qian Zhang",
                "org": "Harbin Inst Technol, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Minist Ind & Informat Technol, Key Lab Micronano Optoelect Informat Syst, Shenzhen 518055, Guangdong, Peoples R China"
            }
        ],
        "venue": "SOLAR ENERGY",
        "year": 2020
    },
    "ddsSkSWJ": {
        "id": "ddsSkSWJ",
        "title": "Accurate determination of the total hemispherical emittance and solar absorptance of opaque surfaces at elevated temperatures",
        "abstract": "",
        "keywords": [
            "spectral reflectance"
        ],
        "authors": [
            {
                "name": "daniel kraemer",
                "org": ""
            },
            {
                "name": "kenneth mcenaney",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "zhifeng ren",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            }
        ],
        "venue": "Solar Energy Materials and Solar Cells",
        "year": 2015
    },
    "BTgHdrZ8": {
        "id": "BTgHdrZ8",
        "title": "Studies on Thermoelectric Properties of n-type Polycrystalline SnSe1-xSx by Iodine Doping",
        "abstract": "Iodine-doped n-type SnSe polycrystalline by melting and hot pressing is prepared. The prepared material is anisotropic with a peak ZT of approximate to 0.8 at about 773 K measured along the hot pressing direction. This is the first report on thermoelectric properties of n-type Sn chalcogenide alloys. With increasing content of iodine, the carrier concentration changed from 2.3 x 10(17) cm(-3) (p-type) to 5.0 x 10(15) cm(-3) (n-type) then to 2.0 x 10(17) cm(-3) (n-type). The decent ZT is mainly attributed to the intrinsically low thermal conductivity due to the high anharmonicity of the chemical bonds like those in p-type SnSe. By alloying with 10 at% SnS, even lower thermal conductivity and an enhanced Seebeck coefficient were achieved, leading to an increased ZT of approximate to 1.0 at about 773 K measured also along the hot pressing direction.",
        "keywords": [],
        "authors": [
            {
                "name": "Qian Zhang",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Eyob Kebede Chere",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Jingying Sun",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Keshab Dahal",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Shuo Chen",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            },
            {
                "name": "Gang Chen",
                "org": "MIT, Dept Mech Engn, Cambridge, MA 02139 USA"
            },
            {
                "name": "Zhifeng Ren",
                "org": "Univ Houston, Dept Phys, Houston, TX 77204 USA"
            }
        ],
        "venue": "ADVANCED ENERGY MATERIALS",
        "year": 2015
    },
    "QeQMAQS2": {
        "id": "QeQMAQS2",
        "title": "A Variety of Gas Detector of Verification and Calibration",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "关武",
                "org": ""
            },
            {
                "name": "白旭",
                "org": ""
            },
            {
                "name": "曹峰",
                "org": ""
            }
        ],
        "venue": "Metrology & Measurement Technique",
        "year": 2013
    },
    "DNl3ykYW": {
        "id": "DNl3ykYW",
        "title": "Determination of Evaporation Residue and Other Items in Composite Packaging Materials",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "范维刚",
                "org": ""
            },
            {
                "name": "穆克然木",
                "org": ""
            },
            {
                "name": "曹峰",
                "org": ""
            }
        ],
        "venue": "Metrology & Measurement Technique",
        "year": 2012
    },
    "V8uwWyfK": {
        "id": "V8uwWyfK",
        "title": "Maintenance and Use and Maintenance of Industrial pH Meter Electrode FAQS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "曹峰",
                "org": ""
            }
        ],
        "venue": "Metrology & Measurement Technique",
        "year": 2012
    },
    "jyjKIYfb": {
        "id": "jyjKIYfb",
        "title": "Trouble Analysis and Shooting in Verification or Calibration of Atomic Absorption Spectrophotometry",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "曹峰",
                "org": ""
            }
        ],
        "venue": "Metrology & Measurement Technique",
        "year": 2012
    },
    "zbbl6GME": {
        "id": "zbbl6GME",
        "title": "Routine Maintenance and Calibration of Inductively Coupled Plasma Quadrupole Mass Spectrometry",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "白旭",
                "org": ""
            },
            {
                "name": "曹峰",
                "org": ""
            }
        ],
        "venue": "Metrology & Measurement Technique",
        "year": 2012
    },
    "S0lfvA2D": {
        "id": "S0lfvA2D",
        "title": "Clinical investigation of intravenous multiple-low-dose L-carnitine in hemodialysis patients",
        "abstract": "OBJECTIVE To evaluate the predialysis and postdialysis plasma concentrations in hemodialysis patients during multiple-low-dose administration of L-carnitine.METHODS Intravenous L-carnitine in hemodialysis patients after each dialysis session in a doseage of 1 g for 8 weeks.The FC level in plasma、dialysate was determined by enzymatic UV test before and after administration of L-carnitine.RESULTS within single hemodialysis session,plasma L-carnitine level decreased by approximately 50%-70%.During repeated administration of L-carnitine,the plasma L-carnitine level increased steadily,reaching a steady state after 8 weeks.CONCLUSION Patients undergoing long-time hemodialysis had plasma L-carnitine level lower than normal.Intravenous multiple-low-dose L-carnitine in hemodialysis patients could improve the dialysis-related carnitine deficiency.",
        "keywords": [
            "intravenous",
            "L-carnitine",
            "hemodialysis"
        ],
        "authors": [
            {
                "name": "CHEN Yan-min",
                "org": "Fuxing Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "Fuxing Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hospital Pharmacy",
        "year": 2007
    },
    "FyjqYCYP": {
        "id": "FyjqYCYP",
        "title": "Application of Antihypertensives in Yuetan Health Service Center and Its Stations",
        "abstract": "Objective To investigate the present situation of antihypertensive application in Yuetan Health Service Centre and its subordinate stations.Methods The antihypertensive sorts,sum of expenses,defined daily doses (DDDs) and defined daily consumption (DDDc) of antihypertensives in prescriptions from November 2007 to February 2008 were analyzed statistically.Results The money expenses of calcium antagonists (CCB),angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocker (ARB) ranked in the first three places.The DDDs of CCB AND ACEI were largest.The DDDc of ARB was highest.Conclusion The CCB is in a leading place in application of antihypertensives in communities.",
        "keywords": [
            "Antihypertensive",
            "Community health service organization",
            "DDDs",
            "DDDc"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": ".Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medicine University,Beijing ,China"
            },
            {
                "name": "DING Jing",
                "org": ".Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medicine University,Beijing ,China"
            },
            {
                "name": "PING Chun-rong",
                "org": ".Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medicine University,Beijing ,China"
            }
        ],
        "venue": "Chinese General Practice",
        "year": 2009
    },
    "nHmuC86Z": {
        "id": "nHmuC86Z",
        "title": "Analysis of Anesthetics Used in Hospitalized Patients During 2004-2007",
        "abstract": "Objective: To investigate the utilization and medication frequency of the anesthetics used in hospitalized patients of our hospital, and to promote the clinical rational use of the anesthetics. Methods: The consumption of anesthetics used in our hospitalized patients was analyzed statistically during 2004- 2007. Results: The anesthetic dosage and cost were increasing year by year. The consumption quantity of morphine was much more than other drugs and the oral administration also increased. Conclusion: The use of anesthetics is almost rational in our hospitalized patients.",
        "keywords": [
            "Anesthetic",
            "Hospitalized patients",
            "DDDs"
        ],
        "authors": [
            {
                "name": "CHEN Yan-min",
                "org": "Department of Pharmacy, Fuxing Hospital Affiliated to Capital University of Medical Science, Beijing, "
            },
            {
                "name": "CAO Feng",
                "org": "Department of Pharmacy, Fuxing Hospital Affiliated to Capital University of Medical Science, Beijing, "
            }
        ],
        "venue": "Chinese Journal of Drug Application and Monitoring",
        "year": 2009
    },
    "daoxLhos": {
        "id": "daoxLhos",
        "title": "68 Adverse drug reactions due to medical herbal material for injection",
        "abstract": "Objective:To investigate adverse reactions caused by Chinese herbal medicines for injection. Methods:A retrospective analysis of 68 adverse drug reactions(ADR)reported from 2003 to 2005 in this hospital was conducted. Results:The most ADRs were classified as allergic reactions, manifesting disorders of skin and its appendage,gastrointestinal tract,CNS,PNS and cardiovascular and respiratory system. Conclusion:Chinese herbal medicine for injection should be closely monitored on their adverse effects.",
        "keywords": [
            "adverse effects",
            "allergic reaction",
            "Chinese herbal medicine for injection"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "Department of Pharmacy, Fuxing Hospital of Capital Medical University, Beijing , China"
            },
            {
                "name": "WANG Jin-yan",
                "org": "Department of Pharmacy, Fuxing Hospital of Capital Medical University, Beijing , China"
            },
            {
                "name": "CHEN Yan-min",
                "org": "Department of Pharmacy, Fuxing Hospital of Capital Medical University, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2006
    },
    "9fbuP3cW": {
        "id": "9fbuP3cW",
        "title": "Application of Anti-Infective in Yuetan Community Health Service Center and Its Subordinate Stations from 2007 to 2009",
        "abstract": "Objective To survey the situation and trend of antibacterial usage in Yuetan health service center and its subordinate stations.Methods The sales volume,drug types,defined daily dose(DDDs) and defined daily cost of antibacterail drugs from 2007 to 2009 were statistically analyzed,and the ration of sequence between amount of money and DDDs of different categories of antibacterial drugs was calculated.Results The sales volumes of antimicrobial drugs were 7.84%,7.52% and 8.06% separately in each year.The oral drugs were most frequently used mode.The first four drugs of DDDs were always Cefuroxime Axetil,Amoxicillin-Clavulanate Potassium,Levofloxacin and Azithromycin.The minimum of defined daily cost were Metronidazole and Norfloxacin.Conclusion The application of the anti-infective drugs is basically rational;however,great attention should be paid to the monitoring on untoward reaction of antimicrobials.",
        "keywords": [
            "ADR",
            "Anti-infective agents",
            "DDDs"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": ".Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medicine University,Beijing ,China"
            },
            {
                "name": "WU Hui-ling",
                "org": ".Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medicine University,Beijing ,China"
            },
            {
                "name": "DING Jing",
                "org": ".Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medicine University,Beijing ,China"
            }
        ],
        "venue": "Chinese General Practice",
        "year": 2011
    },
    "xydSNVZh": {
        "id": "xydSNVZh",
        "title": "Application of Hypoglycemic Drugs in Yuetan Community Health Service Center and Its Subordinate Station",
        "abstract": "Objective To survey the situation and trend of the usage of hypoglycemic drugs in Yuetan health service center and its subordinate station.Methods The sale volume,types,defined daily doses(DDDs) of hypoglycemic drugs from 2009 to 2011 were statistically analyzed.Results The sale volumes of hypoglycemic drugs were 18.1%,19.0% and 22.4% respectively in each year,with a yearly increasing trend.The injection drugs accounted for 20.0%,and the oral drugs were most frequently used form.The top three drugs of DDDs were Metformin,Acarbose,and Gliquidone.Conclusion The usage of hypoglycemic drugs is basically rational,and the diabetics′ blood sugar is effectively controlled according to the guidance of diabetic prevention and control.However,comprehensive treat and management of diabetes mellitus should be strengthened.",
        "keywords": [
            "Community",
            "Hypoglycemic drugs",
            "Defined daily doses"
        ],
        "authors": [
            {
                "name": "DING Jing",
                "org": ",et al.Beijing Xicheng District Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ",et al.Beijing Xicheng District Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Jing-yu",
                "org": ",et al.Beijing Xicheng District Yuetan Community Health Service Center of Fuxing Hospital Affiliated to Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese General Practice",
        "year": 2013
    },
    "fc2ug6Ke": {
        "id": "fc2ug6Ke",
        "title": "Monitoring the concentration of Valproic acid and its clinical sense",
        "abstract": "Objective:To give some informations for rationally administrating oral valproic acid to epileptic patients in clinic.Methods:The serum concentrations of valproic acid of 143 epileptic patients were determined by fluorescence polarization immunoassay.The results and the therapeutic effect were studied.Results:222 of the patients were within the normal concentration range,accounting for 68.5% of total patients observed,while 6 of patients whose serum drug concentration had normal range of concentration did not have their epilepsy controlled,13 of patients had appeared toxic reaction.102 of patients had higher or lower concentration than normal,accounting for 31.5%.Conclusion:The serum concentration monitoring for valproic acid might play a key role in guiding rational use of antiepileptic drugs,there exists big individual among the drug serum concentration.It is suggested that an individual administrated scheme should be applied in clinical practice.",
        "keywords": [
            "Drug administration with individuation",
            "Anti-epileptic drug",
            "Valproic acid",
            "Monitoring serum concentration"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "Affiliated Fuxing Hospital of Capital University of Medical Sciences,Beijing,"
            },
            {
                "name": "CHEN Yan-min",
                "org": "Affiliated Fuxing Hospital of Capital University of Medical Sciences,Beijing,"
            }
        ],
        "venue": "Chinese Journal of Drng Application and Monitoring",
        "year": 2005
    },
    "nPWMLQWk": {
        "id": "nPWMLQWk",
        "title": "Re: How to predict the severity of acute pancreatitis? An ongoing debate",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Liu",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing, Peoples R China"
            },
            {
                "name": "Xiao min Dong",
                "org": "Capital Med Univ, Expt Ctr Basic Med Teaching, Beijing, Peoples R China"
            },
            {
                "name": "Peng yu Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing, Peoples R China"
            },
            {
                "name": "Hai chao Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing, Peoples R China"
            },
            {
                "name": "Bao ju Qi",
                "org": "Capital Med Univ, Daxing Teaching Hosp, Dept Gen Surg, Beijing, Peoples R China"
            },
            {
                "name": "Fei li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing, Peoples R China"
            }
        ],
        "venue": "TURKISH JOURNAL OF GASTROENTEROLOGY",
        "year": 2017
    },
    "Vf19oYQ7": {
        "id": "Vf19oYQ7",
        "title": "Preoperative Concurrent Chemoradiotherapy Combined with Total Mesorectal Excision in Treatment for Locally Advanced Lower Rectal Cancer",
        "abstract": "Objective To evaluate the efficacy of preoperative concurrent chemoradiotherapy combined with total mesorectal excision(TME)in treatment for locally advanced lower rectal cancer.Methods The clinical data of 31 patients with locally advanced lower rectal cancer received concurrent chemoradiotherapy from January 2009 to December 2011 in this hospital were analyzed retrospectively.Conventional fraction radiotherapy with total dose 50 Gy and chemotherapy with mFOLFOX6 or CapeOX regimen were taken.The efficacy was assessed by recording results of clinical and pathological examination.The function of sphincter was also recorded.Results All 31 patients underwent TME operation.The complication morbidity and mortality was 12.9%(4/31)and 3.2%(1/31),respectively.As a result of the preoperative management,the tumor was reduced by an average of 21.9%,down-regulation of T stage was observed in 48.4%(15/31)patients,the frequency of lymph node metastasis decreased from 83.9%(26/31)to 38.7%(12/31).Pathological complete response was observed in 5 patients(16.1%)and the total response rate was 74.2%(23/31),grade 3/4 toxicity was occurred in 2(6.5%)patients.84.6%(22/26)of patients underwent sphincter preservation surgery reserved good function of sphincter.Conclusions Preoperative concurrent chemoradiotherapy combined with TME in treatment for locally advanced lower rectal cancer is effective and safe,which can lead to pathological complete response,decrease the tumor stage and the rate of lymph node metastasis,and can also increase the efficacy of operation.",
        "keywords": [
            "Preoperative chemoradiotherapy",
            "Total mesorectal excision",
            "Rectal cancer"
        ],
        "authors": [
            {
                "name": "LI Ang",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "FANG Yu",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Jia",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHANG Yu-peng",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Dian-gang",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ". Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2012
    },
    "i6Du0h49": {
        "id": "i6Du0h49",
        "title": "Two cases of agenesis of the dorsal pancreas and a review of the literature.",
        "abstract": "Agenesis of the dorsal pancreas (ADP) is a very rare disease with no specific symptoms, and the pathogenesis is not clear. Some patients will be accompanied by other diseases, such as pancreatic tumor or pancreatitis. But most cases are very atypical and difficult to distinguish. Some syndromes of pancreatic exocrine insufficiency are common in patients with ADP. Here, we report two cases of ADP and summarize the clinical features, diagnosis, and treatment of ADP. Case A is a 65-year-old Chinese woman who presented with abdominal pain accompanied by nausea, bloating and acid reflux. The enhanced abdominal CT scan found nothing meaningful except the absence of the body and tail of the pancreas. The diagnosis was considered as gastrointestinal dysfunction cause by exocrine pancreatic insufficiency and recovered after symptomatic treatment. Case B is a 61-year-old Chinese woman who presented with abdominal pain accompanied by fever, vomiting and bloating. The abdominal CT showed multiple stones in the gallbladder, and the body and tail of the patient’s pancreas were absent. She was diagnosed with cholelithiasis and recovered after laparoscopic cholecystectomy. Agenesis of the dorsal pancreas (ADP) is a rare congenital disease with an unclear pathogenesis that presents multiple symptoms. It should be considered when the patients have non-specific, persistent and unexplained symptoms such as bloating or uncontrolled blood sugar. Imaging examination is helpful for diagnosis. And it does not require surgical intervention unless it accompanies other diseases, EPI need to be considered when the non-specific gastrointestinal symptoms appear.",
        "keywords": [
            "Agenesis of the dorsal pancreas (ADP)",
            " Pancreatic disease",
            " Pancreatic dysplasia",
            " Case report"
        ],
        "authors": [
            {
                "name": "Wentong Mei",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"
            },
            {
                "name": "Feng Cao",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"
            },
            {
                "name": "Fei Li",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China"
            }
        ],
        "venue": "BMC Gastroenterology",
        "year": 2020
    },
    "Lm9tX0EN": {
        "id": "Lm9tX0EN",
        "title": "Clinical Application of Laparoscopic Operation for Colon Cancer",
        "abstract": "Objective: To investigate the clinical efficacy of laparoscopic colon cancer surgery.Methods: 44 patients with colon cancer treated in our hospital were picked up and divided into observation group and control group randomly,with 22 cases in each group.The observation group had laparoscopic surgery,and the control group had conventional open surgery.The treatment effectiveness and safety were compared between two groups.Results: The operation time were nearly the same in two groups.There was no statistical difference(P>0.05).Intraoperative blood loss was much fewer,the anus exhaust time,ache lasting time and length of stay in hospital were significantly shorter in observation group than in control group(P<0.05).The complication incidence rates of observation group and control group were 9.09% and 22.73%,respectively,the differences were significant(P<0.05).The local recurrence,metastasis,implantation metastasis and survival rates in two groups have no statistical differences(P>0.05).Conclusion: Laparoscopic colon cancer surgery is effective and safe,with advantages of small wound,fast recovery and few complications.It is suit for widely using in clinic.",
        "keywords": [
            "Laparoscopic operation",
            "Clinical application",
            "Colon cancer"
        ],
        "authors": [
            {
                "name": "YANG Peng",
                "org": " The ICU of mentougou district hospital of Beijing city,Beijing,,China"
            },
            {
                "name": "ZHU Yan",
                "org": " General surgery department Of Xuanwu hospital of The capital university of medical sciences,Beijing,,China"
            },
            {
                "name": "CHEN Hong",
                "org": " General surgery department Of Xuanwu hospital of The capital university of medical sciences,Beijing,,China"
            },
            {
                "name": "YANG Lei",
                "org": " General surgery department Of Xuanwu hospital of The capital university of medical sciences,Beijing,,China"
            },
            {
                "name": "CAO Feng",
                "org": " General surgery department Of Xuanwu hospital of The capital university of medical sciences,Beijing,,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2013
    },
    "F0qSGnxq": {
        "id": "F0qSGnxq",
        "title": "Nonoperative management for perforated peptic ulcer: who can benefit?",
        "abstract": "Although nonoperative management for perforated peptic ulcer (PPU) has been used for several decades, the indication is still unclear. A clinicoradiological score was sought to predict who can benefit from it.A clinicoradiological protocol for the assessment of patients presenting with PPU was used. A logistic regression model was applied to identify determinant variables and construct a clinical score that would identify patients who can be successfully treated with nonoperative management.Of 241 consecutive patients with PPU, 107 successfully received nonoperative management, and 134 required surgery. In multivariable analysis, the following four variables correlated with surgery and were given one point each toward the clinical score: age ≥70 years, fluid collection detection by ultrasound, contrast extravasation detection by water-soluble contrast examination, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score ≥8. Eighty-five percent of patients with a score of 1 or less were successfully treated with nonoperative management, whereas 23 of 29 patients with a score of 3 or more required surgery. The area under the receiver operating characteristic curve was 0.804 (95% confidence interval = 0.717-0.891).By combining clinical, radiological parameters, and APACHE II score, the clinical score allowed early identification of PPU patients who can benefit from nonoperative management.",
        "keywords": [
            "perforated peptic ulcer",
            "surgery",
            "treatment"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "These two authors contributed equally to this work."
            },
            {
                "name": "Jia Li",
                "org": "These two authors contributed equally to this work."
            },
            {
                "name": "Ang Li",
                "org": "Department of General SurgeryXuanwu HospitalCapital Medical UniversityNumber 45, Changchun StreetBeijing100053PR China"
            },
            {
                "name": "Yu Fang",
                "org": "Department of General SurgeryXuanwu HospitalCapital Medical UniversityNumber 45, Changchun StreetBeijing100053PR China"
            },
            {
                "name": "Ya-Jun Wang",
                "org": "Department of General SurgeryXuanwu HospitalCapital Medical UniversityNumber 45, Changchun StreetBeijing100053PR China"
            },
            {
                "name": "Fei Li",
                "org": "Corresponding author. Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China"
            }
        ],
        "venue": "Asian Journal of Surgery",
        "year": 2014
    },
    "97BTnYco": {
        "id": "97BTnYco",
        "title": "Meta-analysis of modified Blumgart anastomosis and interrupted transpancreatic suture in pancreaticojejunostomy after pancreaticoduodenectomy.",
        "abstract": "At current level of evidence, modified Blumgart anastomosis is superior to interrupted transpancreatic suture in terms of grade B/C POPF and intra-abdominal abscess. However, high-grade evidence will be necessary to confirm these results.",
        "keywords": [
            "Meta-analysis",
            "Pancreaticoduodenectomy",
            "Pancreaticojejunostomy"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China."
            },
            {
                "name": "Xiaogang Tong",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China."
            },
            {
                "name": "Ang Li",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China."
            },
            {
                "name": "Jia Li",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China. Electronic address: lij@xwhosp.org."
            },
            {
                "name": "Fei Li",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, PR China. Electronic address: feili36@ccmu.edu.cn."
            }
        ],
        "venue": "Asian journal of surgery",
        "year": 2020
    },
    "CJwuZXub": {
        "id": "CJwuZXub",
        "title": "Percutaneous Catheter Drainage Versus Needle Aspiration in Management of Bacterial Liver Abscess",
        "abstract": "Objective To determine the effectiveness of percutaneous catheter drainage(PCD) and to compare PCD with percutaneous needle aspiration(PNA) in the management of bacterial liver abscess.Methods The medical records of 206 patients with bacterial liver abscess admitted to this hospital between January 1989 and December 2009 were analyzed retrospectively.The outcomes of 96 patients receiving percutaneous treatment including PCD(PCD group,n=56) and PNA(PNA group,n=40) were compared,including the length of hospital stay,rates of procedure-related complications,treatment success,and death.Results There was no statistical difference in patients' demographics or abscess characteristics between two groups(P>0.05).The morbidity,mortality,and length of hospital stay in the PCD group and the PNA group were 1.79% vs 2.50%,1.79% vs 2.50%,and(19.2±13.1) d vs(20.2±12.9) d,respectively,and the P values were 1.000,1.000,and 0.887,respectively.There was statistically significant difference in successful rate between two groups(96.43% vs 75.00%,P=0.002),but all simple abscesses with diameter of 5 cm or less were successfully managed in both PNA group and PCD group(13/13 vs 16/17,P=1.000).Conclusions PCD is more effective than PNA in the management of bacterial liver abscess.PNA can be used as a valid alternative for simple abscesses with 5 cm in diameter or smaller.",
        "keywords": [
            "Percutaneous needle aspiration",
            "Complication",
            "Percutaneous catheter drainage",
            "Bacterial liver abscess"
        ],
        "authors": [
            {
                "name": "LIU Qiang",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ya-jun",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Jia-feng",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2010
    },
    "cAoDOyFc": {
        "id": "cAoDOyFc",
        "title": "Comparison of one-stage resection and anastomosis of acute complete obstruction of right and left colonic carcinoma",
        "abstract": "Objective:To compare the short-term result of one-stage resection and anastomosis for patients with acute complete obstruction of the right and left colonic carcinoma.Methods:The clinical data of 80 patients undergoing emergency one-stage resection and anastomosis of acute complete obstruction for left and right colonic carcinoma were retrospectively analyzed.Results:Thirty-seven patients were operated on for obstructive carcinoma of the right colon,the mortality was 5.4%(2/37),the rate of complication was 21.6%(8/37),the mean hospital stay and cost was(31.6±12.8)d and(52794.9±60804.3)Yuan RMB,respectively.Forty-three patients were operated on for obstructive carcinoma of the left colon.the mortality was 2.3%(1/43),the rate of complication was 25.6%(11/43),the mean hospital stay and cost was(29.6±14.8)d and(50 192.8 ±39 727.4) Yuan RMB respectively.There was one case of anastomotic leakage in both groups.There were no significant differences of mortality and the rate of complication of the two groups.Conclusions:One-stage resection and anastomosis of acute complete obstruction of left colonic carcinoma can be performed as safely as in those with acute obstruction of right.Intraoperative decompression should be considered seriously in left colonic obstruction prior to the anastomosis following colonic resection.",
        "keywords": [
            "Colonic neoplasm·Intestinal obstruction·Resection·Anastomosis"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "WANG Ya-jun",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "LI Fei",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "FANG Yu",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "LI Ang",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "LI Jia",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "ZHANG Yu-peng",
                "org": "Bei-jing 10053,China"
            },
            {
                "name": "SUN Jia-bang",
                "org": "Bei-jing 10053,China"
            }
        ],
        "venue": "Chinese Journal of Current Advances in General Surgery",
        "year": 2009
    },
    "Wm5r4r6C": {
        "id": "Wm5r4r6C",
        "title": "Infection recurrence following minimally invasive treatment in patients with infectious pancreatic necrosis.",
        "abstract": "BACKGROUND In recent decades, an increasing number of patients have received minimally invasive intervention for infected pancreatic necrosis (IPN) because of the benefits in reducing postoperative multiple organ failure and mortality. However, there are limited published data regarding infection recurrence after treatment of this patient population. AIM To investigate the incidence and prediction of infection recurrence following successful minimally invasive treatment in IPN patients. METHODS Medical records for 193 IPN patients, who underwent minimally invasive treatment between February 2014 and October 2018, were retrospectively reviewed. Patients, who survived after the treatment, were divided into two groups: one group with infection after drainage catheter removal and another group without infection. The morphological and clinical data were compared between the two groups. Significantly different variables were introduced into the correlation and multivariate logistic analysis to identify independent predictors for infection recurrence. Sensitivity and specificity for diagnostic performance were determined. RESULTS Of the 193 IPN patients, 178 were recruited into the study. Of them, 9 (5.06%) patients died and 169 patients survived but infection recurred in 13 of 178 patients (7.30%) at 7 (4-10) d after drainage catheters were removed. White blood cell (WBC) count, serum C-reactive protein (CRP), interleukin-6, and procalcitonin levels measured at the time of catheter removal were significantly higher in patients with infection than in those without (allP< 0.05). In addition, drainage duration and length of the catheter measured by computerized tomography scan were significantly longer in patients with infection (P= 0.025 andP< 0.0001, respectively). Although these parameters all correlated positively with the incidence of infection (allP< 0.05), only WBC, CRP, procalcitonin levels, and catheter length were identified as independent predictors for infection recurrence. The sensitivity and specificity for infection prediction were high in WBC count (>= 9.95 x 10(9)/L) and serum procalcitonin level (>= 0.05 ng/mL) but moderate in serum CRP level (cut-off point >= 7.37 mg/L). The catheter length (cut-off value >= 8.05 cm) had a high sensitivity but low specificity to predict the infection recurrence. CONCLUSION WBC count, serum procalcitonin, and CRP levels may be valuable for predicting infection recurrence following minimally invasive intervention in IPN patients. These biomarkers should be considered before removing the drainage catheters.",
        "keywords": [
            "Infectious pancreatic necrosis",
            "Drainage",
            "Minimally invasive intervention",
            "Infection recurrence",
            "C-reactive protein",
            "Procalcitonin"
        ],
        "authors": [
            {
                "name": "Chong-Chong Gao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Jia Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Xiao-Hui Wang",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Ang Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Zhe Wang",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Fei Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            }
        ],
        "venue": "WORLD JOURNAL OF GASTROENTEROLOGY",
        "year": 2020
    },
    "wlGoxPht": {
        "id": "wlGoxPht",
        "title": "Indications of Non-Operative Management for Perforated Peptic Ulcer",
        "abstract": "Objective To discuss the indications of the non-operative management for perforated peptic ulcer.Methods Clinical data of 145 patients with perforated peptic ulcer,aged below 70 years old,with first attack and onset time<12 h,admitted to our hospital between January 2002 and December 2009,were analyzed respectively.Patients who were negative for fluid of abdominopelvic cavity in ultrasound examination and leakage in water-soluble contrast examination received non-operative management,otherwise underwent operation directly(If the patients were being on medication for the ulcer,they should also go directly to surgery).Non-operative patients were converted to operation if the symptom had not relieved during the first 12 h.When admitted,the APACHE Ⅱ score was calculated for all patients.Results Seventy-four and 71 patients underwent non-operative management and operation directly respectively.Sex,age,onset time,perforation site and so on were comparable between the two groups(P>0.05),while APACHE Ⅱ score over 8 was 25.7% and 76.1% respectively with significant difference(P=0.000).In non-operative group,11(14.9%) patients were converted to operation.The mortality(4.1% vs 9.8%,P=0.203),mobility(16.2% vs 25.3%,P=0.175),hospital stay((11.4±2.5) d vs(11.3±1.3) d,P=0.447),and cost((11 657.3±2 826.4) yuan vs(10 013.0±1 877.4) yuan,P=0.212) between two groups had also no significant difference.The mean APACHE Ⅱ score was significant different between the survivors and the dead(9.3 vs 20.2,P=0.000).APACHE Ⅱ score was positively related to mortality and morbility(r=0.98,P=0.000;r=0.52,P=0.000).Conclusions Non-operative management is a safe and effective way in selected patients with perforated peptic ulcer,such as APACHE Ⅱ score ≤8,negative for fluid of abdominopelvic cavity in ultrasound examination,and leakage in water-soluble contrast examination.APACHE Ⅱ score is an important factor in prognosis of these patients.",
        "keywords": [
            "Peptic ulcer",
            "Perforation",
            "Non-operative treatment",
            "Surgical indications",
            "Treatment"
        ],
        "authors": [
            {
                "name": "FANG Yu",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Ang",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHANG Yu-peng",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Dong-bin",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUN Jia-bang",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ya-jun",
                "org": ".General Surgical Department,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2011
    },
    "oM40cBlo": {
        "id": "oM40cBlo",
        "title": "Analysis of Diagnosis and Treatment of Pancreatic Cystic Tumors",
        "abstract": "Objective To discuss the methods of diagnosis and treatment of cystic neoplasms of pancreas.Methods Demographic data,clinical manifestations,diagnostic exams,surgical procedures,pathological diagnosis,postoperative complications,and follow-up data of 29 patients with cystic neoplasms of pancreas were analyzed retrospectively.Results There were 8(28%) serous cystic tumors(SCN),12(41%) mucinous cystic tumors(MCN),3(10%) intraductal papillary mucinous tumors(IPMN),and 6(21%) solid pseudopapillary tumors(SPT).Eight cases of SCN,7 cases of MCN,1 case of IPMN,and 5 cases of SPT were all benign.The ages of the patients were from 15 to 78 years (average,(49±17) years) and all tumors were more common in female(76%,22/29).Twenty-three cases of 29 patients were performed operations,22 cases were underwent surgical resection,and 1 case was performed exploration and biopsy.There was no surgery-related death.The rest 6 cases were not performed operation.Twenty-one cases followed-up for 6 months to 8 years(average,(2.7±2.3) years),8 cases didn't followed-up.Sixteen cases with surgical resection had no recurrence during follow-up period,1 case performed exploration and biopsy died in 1 year after operation,and 4 cases of SCN without surgery didn't deteriorate.Conclusions The most common cystic neoplasms of pancreas are mucinous and serous cysts.These tumors are more frequent in female.Although almost all serous cysts are benign,42% of mucinous cysts are malignant.Misdiagnosis may delay appropriate treatment and increase mortality.The resection rate of pancreatic cystic tumor is high,and the prognosis is good after radical resection.",
        "keywords": [
            "Serous cystic tumor",
            "Solid pseudopapillary tumor",
            "Intraductal papillary mucinous tumor",
            "Pancreatic neoplasms",
            "Mucinous cystic tumor"
        ],
        "authors": [
            {
                "name": "WANG Ya-jun",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUN Jia-bang",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Ang",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "FANG Yu",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Jia",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "JIA jian-guo",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Hong",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Peng",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2012
    },
    "XX7X4U73": {
        "id": "XX7X4U73",
        "title": "A Prognostic Nomogram Based on Immune Scores Predicts Postoperative Survival for Patients with Hepatocellular Carcinoma.",
        "abstract": "Background. Increasing research attention has focused on tumor-infiltrating immune cells. However, the threshold of an immune score for use in predicting overall survival (OS) and disease-free survival (DFS) in hepatocellular carcinoma (HCC) is not defined. This study aims at exploring the association between immune scores with prognosis and building a clinical nomogram for predicting the survival of HCC patients.Material and Methods. A total of 299 patients were enrolled in this study. Their clinical pathological characteristics and immune scores downloaded from The Cancer Genome Atlas (TCGA) database were analyzed. Survival differences between different immune score subgroups were compared, and a final nomogram was built using the Cox proportional hazards regression model. The predictive performance of the nomogram was assessed using the concordance index (C-index) and a calibration plot.Results. All the patients were divided into three subgroups based on immune scores. Patients with medium and high immune scores had significantly better OS (HR and 95% CI: 0.417 [0.186-0.937] and 0.299 [0.146-0.616]) and DFS (HR and 95% CI: 0.575 [0.329-1.004] and 0.451 [0.278-0.733], respectively, compared with those with low immune scores. The C indices for OS and DFS were 0.748 (95% CI, 0.687-0.809) and 0.675 (95% CI, 0.630-0.720), respectively. A calibration plot used to determine the probability of survival at 3 or 5 years (OS and DFS) showed a significant agreement between nomogram predictions and actual observations.Conclusions. Medium and high immune scores are significantly associated with prolonged OS and DFS in HCC patients. Nomograms built in this study can help doctors and patients assess prognosis and guide treatment.",
        "keywords": "",
        "authors": [
            {
                "name": "Jukun Wang",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Chao Zhang",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Ang Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Dongbin Liu",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Fei Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Tao Luo",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            }
        ],
        "venue": "BIOMED RESEARCH INTERNATIONAL",
        "year": 2020
    },
    "CVVQfi1y": {
        "id": "CVVQfi1y",
        "title": "Surgical strategy for middle-preserving pancreatectomy",
        "abstract": "As one of parenchyma-sparing pancreatectomies,middle-preserving pancreatectomy (MPP) has been performed frequently with expanding indications. However,MPP is still an immature surgical procedure with lots of questions,for example,how to maintain enough blood supply to residual pancreas,how to ensure the R0 resection of tumor,and how to determine the function of residual pancreas, and the specific indications and long-term effect of MPP. Owing to the difficulty of the operation and risk of severe complications,MPP is only suitable for trial in experienced center of pancreatic diseases.",
        "keywords": [
            "Fostoperative complications",
            "Pancreastic neoplasms",
            "Pancreatectomy"
        ],
        "authors": [
            {
                "name": "LI Fei",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ". Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)",
        "year": 2013
    },
    "cE3W2on7": {
        "id": "cE3W2on7",
        "title": "Therapeutic effect analysis of preoperative biliary drainage for obstructive jaundice",
        "abstract": "Objective To determine the benefits and harms of preoperative biliary drainage(PBD) for obstructive jaundice.Methods Cochrane systematic evaluation was used to search data between 1966 and 2010 through Cochrane libraries of clinical comparative trials,PubMed,Embase,Cancer Lit and the Chinese BioMedical Literature on disc.The quality of literatures was independently evaluated and cross-checked by two evaluators.The indicators for assessment included overall mortality,overall morbidity and postoperative morbidity.The results were analyzed with RevMan 4.2 software.Results Eight articles were involved in the Meta analysis with total 728 patients.No statistical differences were found in the overall mortality(OR 1.08,95%CI 0.68-1.73,P=0.74),overall morbidity(OR 1.72,95%CI 0.86-3.45,P=0.13) and postoperative morbidity(OR 0.6,95%CI 0.35-1.03,P=0.06) between the groups.Conclusion The potential benefits of PBD in terms of postoperative rates of death and complications do not outweigh the disadvantage of the drainage procedure and should be performed cautiously now.",
        "keywords": [
            "biliary drainage",
            "obstructive jaundice",
            "Meta-analysis"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Practical Surgery",
        "year": 2011
    },
    "JkYQpNAz": {
        "id": "JkYQpNAz",
        "title": "Characteristics in elderly patients over 80 years old with acute abdomen",
        "abstract": "Objective To evaluate the characteristics of diagnosis and treatment in elderly patients over 80 years old with acute abdomen.Methods 5426 elderly patients with acute abdomen were enrolled from January 1,2002 to December 31,2009 in our hospital and were divided into two groups according age: one group with patients≥80 years old(420 cases) and another group <80 years old(5006 cases).Data were analyzed include operability rate,mortality,lenght of stay and admission fee.Results More and more aged patients were treated in hospital.They went to hospital in from 2 h to 21 d after unfitness.They often have several complications including respiratory,cardiovascular system diseases.Compared with<80 group,operability rate was lower(48.09% vs 64.19%,P<0.01),mortality was higher(3.33% vs 1.38%,P<0.01),mean hospital length of stay was longer(16.76±11.49 d vs 14.50±16.08 d,P<0.01),admission fee was more significantly increased(RMB 23 733.11±30 571.75 vs 18 530.83±29 637.46,P<0.01)in group≥80.Conclusions Characteristic of elderly patients should be payed attention to in favor of increasing efficiency in diagnosis and treatment and making medical policy.",
        "keywords": [
            "acute abdomen",
            "characteristics of diagnosis and treatment",
            "aged over 80"
        ],
        "authors": [
            {
                "name": "ZHENG Ya-min",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Qiang",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Dong-bin",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Jia-feng",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ".Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Practical Geriatrics",
        "year": 2011
    },
    "3LHCo5hB": {
        "id": "3LHCo5hB",
        "title": "Clinical features of 85 elderly patients with pyogenic liver abscess",
        "abstract": "Objective To summarize the clinical features and management of 85 elderly patients with pyogenic liver abscess.Methods Two hundred and six patients with pyogenic liver abscess were enrolled from January 1989 to February 2009 and were divided into elderly group(≥60 years) and younger group.The data of the clinical features,laboratory examination,imaging and microbiological examinations,treatment and outcome were analyzed between 2 groups.Results Compared with younger group,the incidence of associated diseases and the levels of serum creatinine(115.1±44.2 mmol/L vs 88.5±37.3 mmol/L,P<0.01) and APACHE Ⅱ score(8.7±4.1 vs 6.2±4.0,P<0.05) in elderly group were higher.Multiple abscess and bilobar abscess were more often found in elderly group than younger group(32.9% vs 20.7%,18.8%vs 8.3%,P<0.05).There were no significant differences in the length of hospital stay,overall complication rate and hospital mortality rate between 2 groups(P>0.05).Conclusions Elderly patients with pyogenic liver abscess have their own characteristics in clinical and laboratory presentation.Active management is tolerated well,with the same prognosis in young patients.",
        "keywords": [
            "treatment",
            "pyogenic liver abscess",
            "aged"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Qiang",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Jia-feng",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Dong-bin",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Practical Geriatrics",
        "year": 2012
    },
    "h0FOjul2": {
        "id": "h0FOjul2",
        "title": "Progression in treatment of colorectal liver metastases with radiofrequency ablation",
        "abstract": "Colorectal liver metastases(CRLM) is the most common metastatic liver cancer.Recent years,radiofrequency(RFA) ablation has been applied more frequently.This review focuses on the treatment of CRLM by RFA.",
        "keywords": [
            "colorectal cancer",
            "liver metastases",
            "radiofrequency ablation",
            "surgery"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Yue-hua",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Clinical Oncology",
        "year": 2009
    },
    "S9i5oujB": {
        "id": "S9i5oujB",
        "title": "Long-Term Outcome of Breast-Conserving Therapy Versus Mastectomy Therapy for Early Stage Invasive Breast Cancer:Result of Meta Analysis",
        "abstract": "Objective To compare the long-term outcome between breast-conserving therapy with mastectomy therapy for early stage invasive breast cancer through a Meta analysis of the randomized controlled trials published worldwide.Methods Cochrane systematic evaluation was used to search through Cochrane libraries of clinical comparative trials,PubMed,Embase,Cancer Lit,and so on.The quality of literatures was independently evaluated and cross-checked by two evaluators,indicators for assessment including death number at the end of follow-up,locoregional and total recurrence.The results were analyzed with RevMan 4.2.2 software.Results Six articles were involved in the Meta analysis with total 3 933 patients.No statistical difference was found in the death at the end of follow-up between breast-conserving therapy group and mastectomy therapy group(OR=1.05,95% CI=0.93-1.19,P=0.45).Locoregional and total recurrence rate of breast-conserving therapy group were statistical higher than those in mastectomy therapy group(OR=1.64,95% CI:1.10-2.44,P=0.01;OR=1.42,95% CI:1.22-1.64,P<0.01).Conclusions Breast-conserving therapy and mastectomy therapy have comparable effects on mortality in patient with early stage invasive breast cancer,even after long-term follow up.However,breast-conserving therapy is associated with significantly greater risk of locoregional recurrence.",
        "keywords": [
            "Breast-conserving surgery",
            "Meta analysis",
            "Breast cancer",
            "Mastectomy"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": ".Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2010
    },
    "NC05MvbX": {
        "id": "NC05MvbX",
        "title": "Continuous Hemofiltration Reduces Mortality in Severe Acute Pancreatitis: A Meta-Analysis.",
        "abstract": "Background. Severe acute pancreatitis (SAP) is a deadly condition, with a mortality rate ranging from 15% to 30%. Recently, blood purification therapy has been adopted in administrating SAP patients. The present study aimed at evaluating the effect of continuous hemofiltration therapy for SAP. Methods. A systematic search of Cochrane Library, PubMed, and Embase was carried out until October 1st, 2019. Prospective studies comparing outcomes for SAP patients between continuous hemofiltration and standard therapy were enrolled. Results. Continuous hemofiltration therapy was associated with lower level of PACHE II score (MD = -1.49; 95% CI: -2.69 to -0.29, P = 0.02), CRP (MD = -1.56 mg/L; 95% CI: -2.64 to -0.47, P = 0.005), Cr (MD = -3.57 umol/L; 95% CI: -5.50 to -1.65, P = 0.003), and Bun (MD = -3.63 mmol/L; 95% CI: -6.07 to -1.20, P = 0.003) at 72 h after onset of treatment. Continuous hemofiltration therapy was associated with shorter length of abdominal pain relief time (MD = -1.82 hours; 95% CI: -2.93 to -0.71, P = 0.001), lower surgery rate (OR = 0.15; 95% CI: 0.03 to 0.78, P = 0.02), and mortality rate (OR = 0.54; 95% CI: 0.37 to 0.77, P = 0.0007). Conclusions. continuous hemofiltration therapy could effectively alleviate SAP as early as 72 hours after onset of treatment, lowering the level of Bun, Cr, CRP, and APACHE II scores. Continuous hemofiltration therapy could confer SAP patients with lower mortality rates.",
        "keywords": "",
        "authors": [
            {
                "name": "Yulin Guo",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            },
            {
                "name": "Chen Li",
                "org": "PLA Army Gen Hosp, Dept Gen Surg, Beijing 100853, Peoples R China"
            },
            {
                "name": "Huaxia Yang",
                "org": "PLA Army Gen Hosp, Dept Gen Surg, Beijing 100853, Peoples R China"
            },
            {
                "name": "Shaoyou Xia",
                "org": "PLA Army Gen Hosp, Dept Gen Surg, Beijing 100853, Peoples R China"
            },
            {
                "name": "Fei Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            }
        ],
        "venue": "EMERGENCY MEDICINE INTERNATIONAL",
        "year": 2020
    },
    "mlJANpLI": {
        "id": "mlJANpLI",
        "title": "Percutaneous and surgical treatment of pyogenic liver abscesses",
        "abstract": "Objective: To assess the effect of percutaneous and surgical treatments of pyogenic liver abscesses. Methods: The medical records of 193 patients with pyogenic liver abscess were analysed retrospectively. The patitents were divided into two groups (percutaneously group and surgical group)according to the different treatment method. The length of hospital stay, pro-cedure-related complications, the rate of treatment success and death were compared between the groups. Results: Ninty-six patients were treated percutaneously, either by needle aspiration or catheter drainage and 97 patients were treated surgically. There was no statistically significant difference in patients' demographics or abscess characteristics between groups. The success rate, mortality and length of hospital stay in percutaneous and surgical group was 87.5% vs 94.8%,2.1% vs 2.1% and(20.8±12.4)d vs(18.9±13.5)d, respectively with no significantly difference (P>0.05). There was statistically significant difference in morbidity rate between the groups (2.1% vs 9.3%, P=0.037). Conclusions: Percutaneous and surgical treatment of pyogenic liver abscesses are both effective, nevertheless percutaneous drainage carries lower morbidity and should be the first-line treatment.",
        "keywords": [
            "operation",
            "pyogenic·Punctures·Surgical procedure",
            "Liver abscess"
        ],
        "authors": [
            {
                "name": "LIU Qiang",
                "org": "Beijing , China"
            },
            {
                "name": "WANG Ya-jun",
                "org": "Beijing , China"
            },
            {
                "name": "CAO Feng",
                "org": "Beijing , China"
            },
            {
                "name": "LIU Dong-bin",
                "org": "Beijing , China"
            },
            {
                "name": "LIU Jia-feng",
                "org": "Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Current Advances in General Surgery",
        "year": 2010
    },
    "sKVU7AlO": {
        "id": "sKVU7AlO",
        "title": "Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis.",
        "abstract": "BACKGROUND Acute pancreatitis (AP) is a common acute abdominal disease worldwide, and its incidence rate has increased annually. Approximately 20% of AP patients develop into necrotizing pancreatitis (NP), and 40% to 70% of NP patients have infectious complications, which usually indicate a worse prognosis. Infection is an important sign of complications in NP patients. AIM To investigate the difference in infection time, infection site, and infectious strain in NP patients with infectious complications. METHODS The clinical data of AP patients visiting the Department of General Surgery of Xuanwu Hospital of Capital Medical University from January 1, 2014 to December 31, 2018 were collected retrospectively. Enhanced computerized tomography or magnetic resonance imaging findings in patients with NP were included in the study. Statistical analysis of infectious bacteria, infection site, and infection time in NP patients with infectious complications was performed, because knowledge about pathogens and their antibiotic susceptibility patterns is essential for selecting an appropriate antibiotic. In addition, the factors that might influence the prognosis of patients were analyzed. RESULTS In this study, 539 strains of pathogenic bacteria were isolated from 162 patients with NP infection, including 212 strains from pancreatic infections and 327 strains from extrapancreatic infections. Gram-negative bacteria were the main infectious species, the most common of which were Escherichia coli and Pseudomonas aeruginosa. The extrapancreatic infection time (9.1 +/- 8.8 d) was earlier than the pancreatic infection time (13.9 +/- 12.3 d). Among NP patients with early extrapancreatic infection (< 14 d), bacteremia (25.12%) and respiratory tract infection (21.26%) were predominant. Among NP patients with late extrapancreatic infection (> 14 d), bacteremia (15.94%), respiratory tract infection (7.74%), and urinary tract infection (7.71%) were predominant. Drug sensitivity analysis showed that P. aeruginosa was sensitive to enzymatic penicillins, third- and fourth-generation cephalosporins, and carbapenems. Acinetobacter baumannii and Klebsiella pneumoniae were sensitive only to tigecycline; Staphylococcus epidermidis and Enterococcus faecium were highly sensitive to linezolid, tigecycline, and vancomycin. CONCLUSION In this study, we identified the timing, the common species, and site of infection in patients with NP.",
        "keywords": [
            "Necrotizing pancreatitis",
            "Extrapancreatic infection",
            "Pathogenic bacteria",
            "Drug sensitivity test"
        ],
        "authors": [
            {
                "name": "Jiong-Di Lu",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Yi-Xuan Ding",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Yu-Duo Wu",
                "org": "Capital Univ Med Sci, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing 100029, Peoples R China"
            },
            {
                "name": "Yu-Lin Guo",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            },
            {
                "name": "Fei Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing 100053, Peoples R China"
            }
        ],
        "venue": "WORLD JOURNAL OF GASTROENTEROLOGY",
        "year": 2019
    },
    "Q2GjvuUb": {
        "id": "Q2GjvuUb",
        "title": "HES 1 is essential for chemoresistance induced by stellate cells and is associated with poor prognosis in pancreatic cancer.",
        "abstract": "The role of pancreatic stellate cells (PSCs) has been established in many studies. However, the potential mechanism for the chemoresistance induced by PSCs has not been fully elucidated. In the present study, human pancreatic cancer cell lines were directly or indirectly co-cultured with PSCs. The inhibition rate and IC50 values were assessed to determine the ability of chemoresistance. RT-PCR and western blot analysis were used to evaluate Hes 1 and Jagged 1 expression before and after co-culture with PSCs. To determine the relationship between Hes 1 expression and survival in pancreatic cancer patients, Kaplan-Meier survival analysis was performed. PSCs promoted the expression of Hes 1 in both PANC-1 and BxPC-3 cell lines and induced chemoresistance to gemcitabine. A Notch signaling pathway inhibitor (L1790) and Hes 1 siRNA reversed the chemoresistance induced by PSCs. In 72 resected pancreatic cancer patients, high Hes 1 expression was observed in 34 patients with shorter overall and progression-free survival times. In conclusion, Hes 1 is essential for chemoresistance induced by PSCs and is associated with poor prognosis in pancreatic cancer patients. Therapy targeting the Notch signaling pathway may reverse chemoresistance and improve survival in patients with pancreatic cancer.",
        "keywords": [
            "cell cycle",
            "oncology",
            "cell",
            "molecular medicine",
            "apoptosis",
            "cancer",
            "gene"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China."
            },
            {
                "name": "Jia Li",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China."
            },
            {
                "name": "Haichen Sun",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China."
            },
            {
                "name": "Shuang Liu",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China."
            },
            {
                "name": "Yeqing Cui",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China."
            },
            {
                "name": "Fei Li",
                "org": "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R. China."
            }
        ],
        "venue": "Oncology reports",
        "year": 2015
    },
    "qSJPklWh": {
        "id": "qSJPklWh",
        "title": "Prognostic significance of positive peritoneal cytology in resectable pancreatic cancer: a systemic review and meta-analysis.",
        "abstract": "Although peritoneal cytology has been used to determine pancreatic cancer staging for more than three decades, its prognostic significance in potentially resectable pancreatic cancer is inconclusive. We therefore conducted this meta-analysis to investigate the impact of peritoneal cytology status on the clinicopathological features and survival outcomes in potentially resectable pancreatic cancer. Ten studies were identified for this meta-analysis after searching the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) electronic databases. Our results showed that positive peritoneal cytology was associated with tumor size (OR 11.65, P = 0.001), tumor location (OR 0.37, P = 0.000), serosal invasion (OR 3.89, P = 0.000), portal vein invasion (OR 1.82, P = 0.016), lymph vessel invasion (OR 2.71, P = 0.026), T stage (OR 2.65, P = 0.037) and N stage (OR 2.34, P = 0.001) in resectable pancreatic cancer. Patients with positive peritoneal cytology demonstrated poor overall survival (OS; HR 3.18, P = 0.000) and disease-free survival (DFS; HR 2.88, P = 0.000) times. Based on our meta-analysis, we conclude that positive peritoneal cytology is an indicator of advanced stage pancreatic cancer with a poor prognosis; hence, radical resection should not be performed on these patients.",
        "keywords": [
            "pancreatic cancer",
            "surgery",
            "cytology",
            "overall survival",
            "meta-analysis"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            },
            {
                "name": "Jia Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            },
            {
                "name": "Ang Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            },
            {
                "name": "Fei Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, Beijing 100053, Peoples R China"
            }
        ],
        "venue": "ONCOTARGET",
        "year": 2017
    },
    "tOJiQ1NK": {
        "id": "tOJiQ1NK",
        "title": "Preoperative diagnosis of pancreatic intraductal papillary mucinous neoplasm",
        "abstract": "With the development of radiology and molecular biology,great progress has been made in the preoperative diagnosis and differential diagnosis of pancreatic intraductal papillary mucinous neoplasm.This paper presents an overview on the advances in this field.",
        "keywords": [
            "Diagnosis",
            "Pancreas",
            "Intraductal papillary mucinous neoplasm"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Dong-bin",
                "org": "Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": "Department of General Surgery,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Journal of Medical Postgraduates",
        "year": 2011
    },
    "E8G7oWP6": {
        "id": "E8G7oWP6",
        "title": "Head and body/tail pancreatic neuroendocrine tumors have different biological characteristics and clinical outcomes.",
        "abstract": "Purpose The incidence of pancreatic neuroendocrine tumors (pNETs) has continued to increase, but for pNETs, there is still no distinction between treatments based on anatomical location. We aim to determine whether NETs located at the head and body/tail of the pancreas are different. Patients and methods Within the Surveillance, Epidemiology, and End Results database (2004-2016), we focused on pNETs patients with comprehensive information. The patients were divided into two groups based on tumors' location. We compared the characteristics of the two groups and assessed the risk factors for lymphatic metastasis. Survival analysis was performed based on the biological characteristics of the tumor. Results In all 3011 patients, pNETs were more common in the body/tail (62.94%) than in the head (37.06%) of the pancreas. The risk factors for lymph node metastasis in the two groups were different. Nonmetastatic, low-grade pancreatic body/tail NETs had the best prognosis (p < 0.001). For low-grade tumors (G1-G2), lymphatic metastasis did not significantly affect the prognosis of patients with pancreatic head NETs (p = 0.098) but affected the overall survival of patients with pancreatic body/tail NETs (p < 0.001). The tumors at the pancreatic head were larger (p = 0.001), more likely to have positive lymph nodes (p < 0.001) and more prone to locally advanced and distant invasion (p < 0.001). The prognosis of pancreatic head NETs 21-40 mm was worse than that of body/tail pNETs (p < 0.001). For non-functional NETs, the overall survival of pancreatic body/tail tumors was better (p < 0.001). Conclusion The pancreatic head and pancreatic body/tail NETs have different biological characteristics and clinical outcomes and they should be treated differently.",
        "keywords": [
            "Pancreatic neuroendocrine tumors",
            "Tumor biological characteristics",
            "Clinical outcomes",
            "Prognosis"
        ],
        "authors": [
            {
                "name": "Wentong Mei",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing, Peoples R China"
            },
            {
                "name": "Yixuan Ding",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing, Peoples R China"
            },
            {
                "name": "Shuo Wang",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing, Peoples R China"
            },
            {
                "name": "Yuchen Jia",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing, Peoples R China"
            },
            {
                "name": "Fei Li",
                "org": "Capital Med Univ, Xuanwu Hosp, Dept Gen Surg, 45 Changchun St, Beijing, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY",
        "year": 2020
    },
    "1ev1Snjs": {
        "id": "1ev1Snjs",
        "title": "Classic Citation Analysis on Surgical Treatment for Type 2 Diabetes",
        "abstract": "Objective To analyze the citation classics articles,and approach the research development history and the research direction in the future about surgical treatment for type 2 diabetes.Methods The most frequently cited articles had published in Social Sciences Citation Index database by the end of October 30,2012 were retrieved.The 50 most frequently cited articles were selected.Articles were evaluated for several characteristics,including number of citations,publication time,country of origin,institution,journal,publication type of article,and authorship.Results The most frequently cited article received 1 751 citations and the least frequently cited article received 73 citations,with a mean of 242.76 citations per article.These citation classics were published in 18 high-impact journals,led by Annals of Surgery and Obesity Research as 10 papers.Of the 50 articles,18 articles were clinical observational study,20 articles concerned basic science,10 articles were review articles,and 2 articles were commentary.These citation classics were published from 1990 to 2009,most of them(40) from 2000 to 2009.Three institutions produced 2 top-cited articles,including Medical College of Virginia,Monash University,and East Carolina University.These articles originated from 14 countries,the top was USA(22 articles).Two persons authored 3 published papers(Cummings DE and Rubino F).Conclusion Most \"citation classics\" in research about surgery for type 2 diabetes are observational studies published in high-impact journals by US-based authors after 1990.",
        "keywords": [
            "Scientometrics",
            "Classic citation analysis",
            "Surgery",
            "Publication",
            "Type 2 diabetes"
        ],
        "authors": [
            {
                "name": "ZHENG Ya-min",
                "org": " Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": " Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Fei",
                "org": " Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2012
    },
    "RjaWVkZQ": {
        "id": "RjaWVkZQ",
        "title": "Landscape Planning of Beijing Tongzhou International Garden",
        "abstract": "Through reviewing background,analyzing base,design basis and location target of Beijing Tongzhou Xintong International Garden residential area,the designing principle,idea and scheme of the project were put forward.For meeting residents’ demand,community-based landscape planning followed by the public semi-public-private logic progressive relationship,emphasizing combination and uniformity of point,line and surface.",
        "keywords": [
            "Principle",
            "Modern style",
            "Enclosed",
            "Fashion"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei "
            }
        ],
        "venue": "Journal of Anhui Agricultural Sciences",
        "year": 2011
    },
    "a84saR8b": {
        "id": "a84saR8b",
        "title": "The landscape design of the \"Five sub-city\" of Tianjin,north residential area",
        "abstract": "Jixian,Tianjin is a historical and cultural city,west of the construction of five foot \"five sub-city\" community and strategic location,the living landscape of the region in order to create an environment of comfortable,healthy and civilized,picturesque living environment for the design philosophy,classical Chinese auspicious the theme of words and patterns to design,Content and form to create a harmonious unity,unique design,superior results with green exotic beautiful environment,not only to meet the spiritual needs of people and good people to meet the rest of the material needs of entertainment",
        "keywords": [
            "Jixian",
            "Five sub-city",
            "landscape",
            "residential area"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "LI Yan",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "WANG Qian",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "LIU Jin-chuan",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            }
        ],
        "venue": "Hebei Journal of Forestry and Orchard Research",
        "year": 2010
    },
    "Zk4Alumy": {
        "id": "Zk4Alumy",
        "title": "Study on the Landscape Architecture Models with Ornamental Halophyte in Tianjin Binhai Area",
        "abstract": "On basis of investigation with resources of wild ornamental halophyte in Tianjin Binhai Area,more than 20 species local halophytes were selected out which have higher ornamental and ecological ualue,the Landscape application was also analized depthly,the Landscape Architecture models with Ornamental Halophyte were put forward in the site of severe degree saline soil and park site,so as to provide reference for Landscape construction of Tianjin Binhai Area.",
        "keywords": [
            "landscape architecture",
            "halophyte resources",
            "ecological value",
            "ornamental value",
            "Tianjin Binhai Area"
        ],
        "authors": [
            {
                "name": "Wen Jing",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding Hebei "
            },
            {
                "name": "Li Yan",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding Hebei "
            },
            {
                "name": "Cao Feng",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding Hebei "
            },
            {
                "name": "Zhang Xiaoman",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding Hebei "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2010
    },
    "wmVJulNA": {
        "id": "wmVJulNA",
        "title": "The research of protection to landscape design",
        "abstract": "To create a modern urban landscape environment not only need to respect history and life,but also require the unity of historical landscape and technological civilization.The rational reuse and adjustment not only can save the resource and construction cost,but also can represent the historical memory of the site.The protection of landscape design as a method,through concrete examples explained the importance of design protection and the methods of protective design were discussed in this paper.How to rebuild the value of the historical landscape and make them be harmonious with nowadays life,development,and aesthetics is a very meaningful topic.",
        "keywords": [
            "protection",
            "landscape design",
            "historical landscape",
            "urban landscape",
            "transformation"
        ],
        "authors": [
            {
                "name": "LI Yan",
                "org": "Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "CAO Feng",
                "org": "Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "FAN Xiao-mei",
                "org": "Agricultural University of Hebei,Baoding ,China"
            }
        ],
        "venue": "Hebei Journal of Forestry and Orchard Research",
        "year": 2011
    },
    "gpWK6jzX": {
        "id": "gpWK6jzX",
        "title": "Landscape Design of the Proctor & Gamble Beijing Technical Center",
        "abstract": "Procter & Gamble Beijing Technical center garden landscape mainly designed roof garden and combined with the design of green space planning practices,Which aimed to present corporate culture and highlight the technology,and culture and technology,space and the arts,the traditional and the modern were unified.On the basis of the \"people first\" principle and practicality,to meet the aesthetic needs,and to improve the human environment,to create a new space,expanding the city's multi-dimensional nature of the green form factors,play a P & G's brand culture \"close to life,and beautify the living\".",
        "keywords": [
            "Roof garden",
            "Space planning",
            "People-oriented",
            "Close to green",
            "Landscaping"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei "
            }
        ],
        "venue": "Journal of Anhui Agricultural Sciences",
        "year": 2010
    },
    "ec7yyOPR": {
        "id": "ec7yyOPR",
        "title": "Cultural Origins of the Lotus Pond's Landscape Construction in Baoding",
        "abstract": "The ancient Lotus Pond,located in Baoding,Hebei Province,China,is a compounded buildings and gardens integrated with the functions of landscape architecture,school,and royal palace.Its construction deeply influenced by traditional Chinese cultures,such as confucianism,taoism,and buddhism.It included traditional Chinese culture of landscape and architecture,manifested by its construction philosophy of adoring the nature,enjoying green mountains and beautiful water.By analyzing intention and conception of the Lotus Pond,its cultural thought and taste of artistic conception hiding in the architectural language.",
        "keywords": [
            "landscape construction",
            "buddhism",
            "Lotus Pond",
            "taoism",
            "culture",
            "confucianism"
        ],
        "authors": [
            {
                "name": "SHENG Ran",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei ,China"
            },
            {
                "name": "CAO Feng",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei ,China"
            },
            {
                "name": "LIU Gui-lin",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei ,China"
            },
            {
                "name": "LIU Hai-bo",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei ,China"
            },
            {
                "name": "WANG Yan",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei ,China"
            },
            {
                "name": "WANG Jing-hua",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding,Hebei ,China"
            }
        ],
        "venue": "Journal of Northwest Forestry University",
        "year": 2009
    },
    "2U922LVf": {
        "id": "2U922LVf",
        "title": "Landscaping planning on the residential green space of Yezhuang Country of Tangxian",
        "abstract": "According to the Outline About Overall Planning of:Yezhuang Country,we carry on a overall greening planning in oder to improve the green coverage and ecological environment.Paper analyzed the problems faced by the Yezhuang Country,designed to response to specific problems in planning.It not only reserves the original special features,but also integrates modern elements to it,in order to set up a village whith has the character of the \"Garden City\",and providing a comfortable,of well ecological living condition to the residents.",
        "keywords": [
            "greening level",
            "residence",
            "well ecological",
            "character of county"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": " College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "WANG Qian",
                "org": " College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "GENG He-ping",
                "org": " Fuping Forestry Bureau of Hebei,Fuping ,China"
            }
        ],
        "venue": "Hebei Journal of Forestry and Orchard Research",
        "year": 2010
    },
    "z78ARaBc": {
        "id": "z78ARaBc",
        "title": "Study on landscape details",
        "abstract": "The construction of a morden Landscape Architecture which is high-quality,humanized design and characteristic needs pay attention to Landscape details.In this paper,according to the in-depth research of the details arrive at a conclusion that Landscape details design must be considered together with the whole landscape,and to ensure that from the detailed design to construction and then to the later maintenance one by onet.Furthermore,solution countermeasures for missing Landscape details were presented with a view to the future research of Landscape details.",
        "keywords": [
            "later maintenance",
            "landscape details",
            "detail design",
            "solution countermeasure",
            "construction"
        ],
        "authors": [
            {
                "name": "WEN Jing",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "CAO Feng",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            },
            {
                "name": "WANG Qian",
                "org": "College of Landscape Architecture and Tourism,Agricultural University of Hebei,Baoding ,China"
            }
        ],
        "venue": "Hebei Journal of Forestry and Orchard Research",
        "year": 2010
    },
    "JhYf5lLw": {
        "id": "JhYf5lLw",
        "title": "Some issues related to soil-groundwater environment research in northern Haihe plain,China",
        "abstract": "Northern Haihe plain in situated within the semi-arid region of China is still being more and more arid.Proluvio-fluvial plain,fluvial plain,fluvial-marine plain is in deposit sequence from hillside to seashore in northern Haihe plain.The contents of Ca,Mg and F in soil are high,and Se,Mo and I are low.The soil is featured by weak alkaline and is now acidizing.The unconfined groundwater is fresh or fresh-salty and weak alkaline but being basification.Together with natural driving force,artificial driving force has becoming one of the important driving forces to the evolution of soil-groundwater environment,which plays different role in different area.The soil environment is good and the groundwater environment is not good.But both of them are being aggravated.",
        "keywords": [
            "some scientific problems",
            "evolution and driving forces",
            "soil-groundwater environment",
            "northern Haihe plain"
        ],
        "authors": [
            {
                "name": "LI Rui-min",
                "org": "China Institute for Geo-environmental Monitoring,Beijing ,China"
            },
            {
                "name": "WANG Yi",
                "org": "China Institute for Geo-environmental Monitoring,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute for Geo-environmental Monitoring,Beijing ,China"
            },
            {
                "name": "XU Hui-zhen",
                "org": "China Institute for Geo-environmental Monitoring,Beijing ,China"
            },
            {
                "name": "LIU Yong-sheng",
                "org": "China Institute for Geo-environmental Monitoring,Beijing ,China"
            },
            {
                "name": "HAO Chun-ming",
                "org": "China Institute for Geo-environmental Monitoring,Beijing ,China"
            },
            {
                "name": "MA Zhong-she",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "GUO Hai-quan",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "ZHAO Geng-xin",
                "org": "Tianjin Institute of Geology and Mineral Resources,China Geological Survey,Tianjin ,China"
            },
            {
                "name": "CAO Shu-ping",
                "org": "Tianjin Institute of Geological Survey,Tianjin ,China"
            },
            {
                "name": "LI Wen-wei",
                "org": "Beijing Institute of Geological Survey,Beijing ,China"
            },
            {
                "name": "LIU Feng-chuan",
                "org": "Hebei Institute of Geo-environment Monitoring,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "LIU Jiu-rong",
                "org": "Beijing Institute of Geo-environment Monitoring,Beijing ,China"
            },
            {
                "name": "LIN Jian",
                "org": "Beijing Institute of Geo-environment Monitoring,Beijing ,China"
            },
            {
                "name": "XU Yi-qing",
                "org": "School of Environmental Study,China University of Geosciences,Wuhan ,Hubei,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2010
    },
    "pYd4AfLD": {
        "id": "pYd4AfLD",
        "title": "The Investigation and Evaluation of the Heavy Metal Pollution in Farmland Soil and Crop in the Qingyuan of Hebei, China",
        "abstract": "Based on the 1∶250 000 target regional geochemical survey of Hebei geological survey bureau, study the soil and corn seeds sampling, analyse the area of soil heavy metal concentration degree emphatically, and use enrichment factor and single factor soil pollution index methods for contamination assessment. Results showed that the soil of the study area was polluted by Cu, Zn, Cr, Pb and Cd seriously, includ- ing Cd had achieved significant enrichment degree;it indicated that the crop had been polluted though the statistical of the heavy metal in the corn seeds, such as the content of Ni and Pb in corn seeds exceed the food hygiene standards. Through the geo-statistical methods to analyse and reveal the spatial distribution characteristics of the heavy metal of Zn, Cu, Pb and Cr which had serious pollution, and explore the main reasons of heavy metal pollution.",
        "keywords": [
            "farmland soil",
            "heavy metal",
            "Qingyuan of Hebei",
            "pollution evaluation",
            "crop"
        ],
        "authors": [
            {
                "name": "ZHANG Li-hong",
                "org": "China University of Geosciences, Beijing , China"
            },
            {
                "name": "XU Hui-zhen",
                "org": "China Institute of Geo-Environment Monitoring, Beijing , China"
            },
            {
                "name": "YU Qing-chun",
                "org": "China University of Geosciences, Beijing , China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute of Geo-Environment Monitoring, Beijing , China"
            },
            {
                "name": "MA Zhong-she",
                "org": "Ge-ology Survey Institution of Hebei Province, Shijiazhuang , China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute of Geo-Environment Monitoring, Beijing , China"
            },
            {
                "name": "LI Hong-liang",
                "org": "Ge-ology Survey Institution of Hebei Province, Shijiazhuang , China"
            }
        ],
        "venue": "Journal of Agro-Environment Science",
        "year": 2010
    },
    "KFi3NaQZ": {
        "id": "KFi3NaQZ",
        "title": "Preliminary study on source area and physical and chemical characteristics for aeoliandust deposits in Beijing,China",
        "abstract": "The intention of this paper is to survey dust in atmosphere of Beijing City.The purpose of this research is figuring out the relation of the dust and soil around Beijing.The dust samples of different height at 325m Meteorological Tower of Institute of Atmospheric Physics(IAP) were collected in two time period(2007.6.7-2007.11.6 and 2007.11.6-2008.6.12).The characters of physical and chemical analysis indicated that the primary factor of influence dust is wind power which has perfectly mixed the matter of local place and far off place.The matters of far off place are much more than local place with height increasing.It has a linear relation between ratio of Si/Al and heigth of dust sample.From the relation,we can imprecisely figure out the approximate heigth of the equal proportion mix matter in local place and far off place.",
        "keywords": [
            "ratio of Si/Al",
            "factor enrichment",
            "dust",
            "factors analysis",
            "Beijing",
            "REE"
        ],
        "authors": [
            {
                "name": "LIU Yong-sheng",
                "org": "China University of Geosciences,Beijing ,China"
            },
            {
                "name": "YANG Bing",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "WANG Yi",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "XU Hui-zhen",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "LI Ai-guo",
                "org": "Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2010
    },
    "PO7NPjjt": {
        "id": "PO7NPjjt",
        "title": "Geologic and geochemical evolutive feature of topsoil in northland of Haihe River piedmont plain to coastal plain,China",
        "abstract": "This article is based on the analysis of top soil powder size,mineral composition and element geochemistry character in the different types of geomorphology in northland of Haihe plain.The result shows that the geologic and geochemical characteristics of top soil from piedmont plain to coastal plain are controled by depositional environment,and the characteristics chang with the geomorphology and sedimentary environment.",
        "keywords": [
            "evolutive feature",
            "geology and geochemistry",
            "topsoil",
            "depositional environment",
            "Haihe plain"
        ],
        "authors": [
            {
                "name": "WANG Yi",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "MA Zhong-she",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "GUO Hai-quan",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "MA Hao",
                "org": "China University of Geosciences,Beijing ,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2010
    },
    "1tgEy4SR": {
        "id": "1tgEy4SR",
        "title": "THE STUDY AND APPLICATION OF THE RESPONSE RELATION ABOUT CHROMIUM IN THE SOIL-WHEAT SYSTEM IN HUANGHUAI PLAIN,HENAN PROVINCE,CHINA",
        "abstract": "By using the data from Agricultural Geological Environment Survey in the Huanghuai Plain,Henan Province,the distribution of chromium in the soil-wheat system was analyzed.Through research on the correlativity of Cr contents between wheat seed and soil,the physical and chemical properties of the soil parameters,and different chromium configurations,the statistical model of forecasting Cr contents of wheat seed has been established under the above conditions.It can provide the scientific basis for the ecological risk analysis on the basis of the response relation of Cr.",
        "keywords": [
            "response relation",
            "correlation analysis",
            "forecasting model",
            "chromium",
            "wheat seed",
            "soil"
        ],
        "authors": [
            {
                "name": "HE Feng",
                "org": "Environment College,China University of Geosciences,Wuhan ,China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute of Geo-environment Monitoring,Beijing ,China"
            },
            {
                "name": "WANG Yi",
                "org": "China Institute of Geo-environment Monitoring,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute of Geo-environment Monitoring,Beijing ,China"
            },
            {
                "name": "ZHANG Yan-ping",
                "org": "Henan Institute of Geology Survey,Zhengzhou ,China"
            },
            {
                "name": "HU Yong-hua",
                "org": "Henan Institute of Geology Survey,Zhengzhou ,China"
            },
            {
                "name": "WAN Jun-wei",
                "org": "Environment College,China University of Geosciences,Wuhan ,China"
            }
        ],
        "venue": "Earth and Environment",
        "year": 2008
    },
    "gwbBpa09": {
        "id": "gwbBpa09",
        "title": "Indicator of selenium in soils for land ecological security assessments in the Datong basin,northern Shanxi,China",
        "abstract": "Geochemical investigation of Se concentrations in softs in the Datong basin and study of the relation of the selenium con- centration of 160 groups of maize grain and that in its rhizosphere softs indicate that:(1) the selenium concentration of top softs in the Datong basin generally ranges from 100 to 200 ng/g,with an average of 152 ng/g,;(2) the selenium concentration of maize grain had a reasonable correspondence with the total concentration of selenium and concentrations of water-soluble,ion-exchange and carbon- ate Se species in top softs,which statistically verifies the hypothesis that the mineral nutrient elements in plants are mainly derived from softs and solutions in softs;(3) the total concentration of selenium in top softs may serve as one of the important indicators for soft envi- ronmental quality assessments and it is proposed that the standard values for assessments of selenium deficiency and sufficiency be 180 ng/g and 360 ng/g respectively;and (4) soils in which selenium is extensively deficient or sufficient in the study area of the Datong basin are distributed only in Hunyuan County and the east of the Shuozhou area.",
        "keywords": [
            "Datong basin",
            "Indicator of evaluation",
            "Se in soils",
            "Standard of evaluation"
        ],
        "authors": [
            {
                "name": "LI Rui-min",
                "org": ""
            },
            {
                "name": "WANG Zhi-nong",
                "org": ""
            },
            {
                "name": "CAO Feng",
                "org": ""
            },
            {
                "name": "JiHua Zhou",
                "org": "Shanxi Institute of Geological Survey(Shanxi Institute of Geological Survey,Shanxi Geological Survey),Taiyuan,China"
            },
            {
                "name": "WANG Jian-wu",
                "org": "Shanxi Institute of Geological Survey,Taiyuan ,Shanxi,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2007
    },
    "N49YVmq4": {
        "id": "N49YVmq4",
        "title": "Soil geochemical baseline and environmental background values in northern Haihe plain,China",
        "abstract": "Based on the data obtained from the multipurpose regional geochemical survey(1:250000) in the Beijing,Tianjin and Heibei Province,and the basic conception of geochemical baseline and environmental background values,the study area(Northern Haihe plain) was divided into three statistical units in light of the different depositional conditions.By using the method of standardization,that is,after repeatedly crossing out the surface soil anomalous data,geochemical baselines of various indicators were obtained through the correlation between other elements and inert element Ti,and after repeatedly crossing out the deep soil anomalous data,mean values,standard deviations and variation coefficients of 34 indicators were obtained,and thus characterized the background values.The above study may be cited as major scientific basis for regional soil environmental quality evaluation and monitoring.",
        "keywords": [
            "soil environmental background values",
            "geochemical baseline",
            "northern Haihe plain"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "WANG Yi",
                "org": "China Institute for Geo-Environmental Monitoring,Beijing ,China"
            },
            {
                "name": "MA Zhong-she",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "GUO Hai-quan",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "ZHAO Geng-xin",
                "org": "Tianjin Centre,China Geological Survey,Tianjin ,China"
            },
            {
                "name": "CAO Shu-ping",
                "org": "Tianjin Institute of Geological Survey,Tianjin ,China"
            },
            {
                "name": "LI Wen-wei",
                "org": "Beijing Institute of Geo-exploration Technology,Beijing ,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2010
    },
    "6SpuPehS": {
        "id": "6SpuPehS",
        "title": "The main soilgroundwater environmental problems and influencing factors in northern Haihe plain,China",
        "abstract": "Taking soil and unconfined groundwater as a interreaction system,soil acidification and groundwater alkalinization and wetland degradation were analyzed in study area in this paper.The influencing factors of soil and unconfined groundwater environment were analyzed.Based on the realtest date of soil profiles and groundwater monitoring date,the research results were educed that soil environment was controlled mainly by natural factor,but the influence of human activity could not be ignored;unconfined groundwater environment was controlled by natural factor and human activity.The conclusion is very important for protecting soil and groundwater environment.",
        "keywords": [
            "wetland degradation",
            "groundwater alkalinization",
            "human activity",
            "soil acidification",
            "natural factor",
            "northern Haihe plain"
        ],
        "authors": [
            {
                "name": "XU Hui-zhen",
                "org": "China Institute for Geo-Environmental Monitoring,Beijng ,China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute for Geo-Environmental Monitoring,Beijng ,China"
            },
            {
                "name": "WANG Yi",
                "org": "China Institute for Geo-Environmental Monitoring,Beijng ,China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute for Geo-Environmental Monitoring,Beijng ,China"
            },
            {
                "name": "MA Zhong-she",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "GUO Hai-quan",
                "org": "Hebei Institute of Geological Survey,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "LIU Jiu-rong",
                "org": "Beijing Geo-Environmental Monitoring Station,Beijing ,China"
            },
            {
                "name": "LIN Jian",
                "org": "Beijing Geo-Environmental Monitoring Station,Beijing ,China"
            },
            {
                "name": "CAO Shu-ping",
                "org": "Tianjin Institute of Geological Survey,Tianjin ,China"
            },
            {
                "name": "ZHANG Ya-na",
                "org": "Tianjin Institute of Geological Survey,Tianjin ,China"
            },
            {
                "name": "LIU Feng-chuan",
                "org": "Heibei Geo-Environmental Monitoring Station,Shijiazhuang ,Hebei,China"
            },
            {
                "name": "ZHAO Jie",
                "org": "Heibei Geo-Environmental Monitoring Station,Shijiazhuang ,Hebei,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2010
    },
    "UetmSq4c": {
        "id": "UetmSq4c",
        "title": "Ecological safely evaluation of Cr in soils based on the soil-seed system in Henan,China",
        "abstract": "Cr safety limits in different soil types were obtained by using the method and principle of agro-geological geochemical evaluation and measured data of Cr in the soil-wheat system in the Henan Huanghuai plain,Henan.Then the \"practical critical values\" were used to revise the safely limits and establish the evaluation standard value.Finally,the evaluation standard value was used to conduct the Cr ecological safety evaluation of soils in Henan.",
        "keywords": [
            "Agro-geological geochemical evaluation",
            "Cr content",
            "Ecological safety estimation",
            "Henan",
            "Soil-wheat system"
        ],
        "authors": [
            {
                "name": "HE Feng",
                "org": "Environment College,China University of Geosciences,Wuhan ,Hubei,China"
            },
            {
                "name": "LI Rui-min",
                "org": "China Institute of Geo-Environment Monitoring,Beijing ,China"
            },
            {
                "name": "WANG Yi",
                "org": "China Institute of Geo-Environment Monitoring,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "China Institute of Geo-Environment Monitoring,Beijing ,China"
            },
            {
                "name": "YongHua Hu",
                "org": "Henan Provincial Geological Survey Institute(Henan Institute of Geological Survey),Zhengzhou,China"
            },
            {
                "name": "ZhiKun Wang",
                "org": "Henan Provincial Geological Survey Institute(Henan Institute of Geological Survey),Zhengzhou,China"
            },
            {
                "name": "WAN Jun-wei",
                "org": "Environment College,China University of Geosciences,Wuhan ,Hubei,China"
            }
        ],
        "venue": "Geological Bulletin of China",
        "year": 2008
    },
    "y5X0uWbk": {
        "id": "y5X0uWbk",
        "title": "Molecular Imaging of Apelin on Proliferation and Function of Adipose Tissue Derived Mesenchymal Stem Cells: Molecular Imaging of Apelin on Proliferation and Function of Adipose Tissue Derived Mesenchymal Stem Cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dong liang",
                "org": ""
            },
            {
                "name": "l i shuang",
                "org": ""
            },
            {
                "name": "rongqing zhang",
                "org": ""
            },
            {
                "name": "l i congye",
                "org": ""
            },
            {
                "name": "shunming zhu",
                "org": ""
            },
            {
                "name": "lina gao",
                "org": ""
            },
            {
                "name": "haichang wang",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "cFmzyWpi": {
        "id": "cFmzyWpi",
        "title": "Abstract 8993: Protective Effects of Glucagon-like Peptide-1 on Cardiac Microvessels Injury via cAMP/PKA/Rho Dependent Pathway in Diabetic Rats",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dongjuan wang",
                "org": ""
            },
            {
                "name": "peng luo",
                "org": ""
            },
            {
                "name": "haichang wang",
                "org": ""
            },
            {
                "name": "nan liu",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2012
    },
    "BVekqsxK": {
        "id": "BVekqsxK",
        "title": "Abstract 16334: Molecular Imaging of Atherosclerotic Plaque via Profilin-1 Antibody Labeled PEI-Fe3O4 Magnetic Nanoparticles",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yabin Wang",
                "org": ""
            },
            {
                "name": "Tao Su",
                "org": ""
            },
            {
                "name": "Shun Qi",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2013
    },
    "rJGqgZYf": {
        "id": "rJGqgZYf",
        "title": "Autophagy regulates the apoptosis of bone marrow-derived mesenchymal stem cells under hypoxic condition via AMP-activated protein kinase/mammalian target of rapamycin pathway.",
        "abstract": "Bone marrow-derived mesenchymal stem cells (BM-MSCs) have been demonstrated as an ideal autologous stem cells source for cell-based therapy for myocardial infarction (MI). However, poor viability of donor stem cells after transplantation limits their therapeutic efficiency, whereas the underlying mechanism is still poorly understood. Autophagy, a highly conserved process of cellular degradation, is required for maintaining homeostasis and normal function. Here, we investigated the potential role of autophagy on apoptosis in BM-MSCs induced by hypoxic injury. BM-MSCs, isolated from male C57BL/6 mice, were subjected to hypoxia and serum deprivation (H/SD) injury for 6, 12, and 24 h, respectively. The autophagy state was regulated by 3-methyladenine (3MA) and rapamycin administration. Furthermore, compound C was administrated to inhibit AMPK. The apoptosis induced by H/SD was determined by TUNEL assays. Meanwhile, autophagy was measured by GFP-LC3 plasmids transfection and transmission electron microscope. Moreover, protein expressions were evaluated by Western blot assay. In the present study, we found that hypoxic stress increased autophagy and apoptosis in BM-MSCs time dependently. Meanwhile, hypoxia increased the activity of AMPK/mTOR signal pathway. Moreover, increased apoptosis in BM-MSCs under hypoxia was abolished by 3-MA, whereas was aggravated by rapamycin. Furthermore, the increased autophagy and apoptosis in BM-MSCs induced by hypoxia were abolished by AMPK inhibitor compound C. These data provide evidence that hypoxia induced AMPK/mTOR signal pathway activation which regulated the apoptosis and autophagy in BM-MSCs. Furthermore, the apoptosis of BM-MSCs under hypoxic condition was regulated by autophagy via AMPK/mTOR pathway.",
        "keywords": [
            "AMPK/mTOR",
            "apoptosis",
            "autophagy",
            "bone marrow-mesenchymal stem cells",
            "hypoxia"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Ming Yang",
                "org": "Taishan Med Univ, Sch Basic Med Sci, Tai An 271000, Shandong, Peoples R China"
            },
            {
                "name": "Yabin Wang",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Le Wang",
                "org": "Guangzhou Med Univ, Affiliated Hosp 3, Inst Orthopaed & Traumatol, Guangzhou 510000, Guangdong, Peoples R China"
            },
            {
                "name": "Zhitao Jin",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Liping Ding",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Lijuan Zhang",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Lina Zhang",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Wei Jiang",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Guojie Gao",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Junke Yang",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Bingwei Lu",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Taohong Hu",
                "org": "Gen Hosp PLA Rocket Force, Dept Cardiol, Beijing 100088, Peoples R China"
            }
        ],
        "venue": "CELL BIOLOGY INTERNATIONAL",
        "year": 2016
    },
    "6AECh0pQ": {
        "id": "6AECh0pQ",
        "title": "e0082 Molecular imaging of apelin on survival and function of mesenchymal stem cells in hindlimb mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dong liang",
                "org": "fourth military medical university"
            },
            {
                "name": "w li",
                "org": "fourth military medical university"
            },
            {
                "name": "shuang li",
                "org": "fourth military medical university"
            },
            {
                "name": "rongqing zhang",
                "org": "fourth military medical university"
            },
            {
                "name": "lina gao",
                "org": "fourth military medical university"
            },
            {
                "name": "shunming zhu",
                "org": "fourth military medical university"
            },
            {
                "name": "yabin wang",
                "org": "fourth military medical university"
            },
            {
                "name": "haichang wang",
                "org": "fourth military medical university"
            },
            {
                "name": "feng cao",
                "org": "fourth military medical university"
            }
        ],
        "venue": "Heart",
        "year": 2010
    },
    "lRNIYcdb": {
        "id": "lRNIYcdb",
        "title": "CARDIOPROTECTIVE EFFECTS OF TANSHINONE IIA PRETREATMENT VIA KININ B2 RECEPTOR-AKT-GSK-3ß DEPENDENT PATHWAY IN EXPERIMENTAL DIABETIC CARDIOMYOPATHY",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dongdong sun",
                "org": ""
            },
            {
                "name": "haichang wang",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2011
    },
    "OhdmeUdL": {
        "id": "OhdmeUdL",
        "title": "[Exploration of omics mechanism and drug prediction of coronavirus-induced heart failure based on clinical bioinformatics].",
        "abstract": " Present study investigated the mechanism of heart failure associated with coronavirus infection and predicted potential effective therapeutic drugs against heart failure associated with coronavirus infection.  Coronavirus and heart failure were searched in the Gene Expression Omnibus (GEO) and omics data were selected to meet experimental requirements. Differentially expressed genes were analyzed using the Limma package in R language to screen for differentially expressed genes. The two sets of differential genes were introduced into the R language cluster Profiler package for gene ontology (GO) and Kyoto gene and genome encyclopedia (KEGG) pathway enrichment analysis. Two sets of intersections were taken. A protein interaction network was constructed for all differentially expressed genes using STRING database and core genes were screened. Finally, the apparently accurate treatment prediction platform (EpiMed) independently developed by the team was used to predict the therapeutic drug.  The GSE59185 coronavirus data set was searched and screened in the GEO database, and divided into wt group, ΔE group, Δ3 group, Δ5 group according to different subtypes, and compared with control group. After the difference analysis, 191 up-regulated genes and 18 down-regulated genes were defined. The GEO126062 heart failure data set was retrieved and screened from the GEO database. A total of 495 differentially expressed genes were screened, of which 165 were up-regulated and 330 were down-regulated. Correlation analysis of differentially expressed genes between coronavirus and heart failure was performed. After cross processing, there were 20 GO entries, which were mainly enriched in virus response, virus defense response, type Ⅰ interferon response, γ interferon regulation, innate immune response regulation, negative regulation of virus life cycle, replication regulation of viral genome, etc . There are 5 KEGG pathways, mainly interacting with tumor necrosis factor signaling pathway, IL-17 signaling pathway, cytokine and receptor interaction, Toll-like receptor signaling pathway, human giant cells viral infection related. All differentially expressed genes were introduced into the SREING online analysis website for protein interaction network analysis, and core genes such as signal transducer and activator of transcription 3, IL-10, IL17, TNF, interferon regulatory factor 9, 2'-5'-oligoadenylate synthetase 1, mitogen-activated protein kinase 3, radical s-adenosyl methionine domain containing 2, c-x-c motif chemokine ligand 10, caspase 3 and other genes were screened. The drugs predicted by EpiMed's apparent precision treatment prediction platform for disease-drug association analysis are mainly TNF-α inhibitors, resveratrol, ritonavir, paeony, retinoic acid, forsythia, and houttuynia cordata.  The abnormal activation of multiple inflammatory pathways may be the cause of heart failure in patients after coronavirus infection. Resveratrol, ritonavir, retinoic acid, amaranth, forsythia, houttuynia may have therapeutic effects. Future basic and clinical research is warranted to validate present results and hypothesis.",
        "keywords": [
            "Bioinformatics",
            "Coronavirus infections",
            "Drug prediction",
            "Heart failure"
        ],
        "authors": [
            {
                "name": "X M Chen",
                "org": "National Medical Center for Geriatric Diseases, Department of Hematology, Second Medical Center, General Hospital of Chinese People's Liberation Army, Beijing 100853, China."
            },
            {
                "name": "F Cao",
                "org": "Department of Cardiology, First Medical Center, General Hospital of Chinese People's Liberation Army, Beijing 100853, China."
            },
            {
                "name": "H M Zhang",
                "org": "National Medical Center for Geriatric Diseases, Department of Hematology, Second Medical Center, General Hospital of Chinese People's Liberation Army, Beijing 100853, China."
            },
            {
                "name": "H R Chen",
                "org": "School of Management, Shanxi Medical University, Taiyuan 0300022, China."
            },
            {
                "name": "J D Zhang",
                "org": "Graduate school of Medical College of Chinese People's Liberation Army, Beijing 100853, China."
            },
            {
                "name": "P Zhi",
                "org": "School of Management, Shanxi Medical University, Taiyuan 0300022, China."
            },
            {
                "name": "Z Y Li",
                "org": "School of Management, Shanxi Medical University, Taiyuan 0300022, China."
            },
            {
                "name": "Y X Wang",
                "org": "Department of Traditional Chinese Medicine, Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China."
            },
            {
                "name": "X C Lu",
                "org": "National Medical Center for Geriatric Diseases, Department of Hematology, Second Medical Center, General Hospital of Chinese People's Liberation Army, Beijing 100853, China."
            }
        ],
        "venue": "Zhonghua xin xue guan bing za zhi",
        "year": 2020
    },
    "ChDVR3tv": {
        "id": "ChDVR3tv",
        "title": "Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction.",
        "abstract": "This study demonstrates that HPC may improve the functional survival and the therapeutic efficiencies of engrafted BM-MSCs, at least in part through autophagy regulation. Hypoxic preconditioning may serve as a promising strategy for optimizing cell-based cardiac regenerative therapy.",
        "keywords": [
            "Apoptosis",
            "Autophagy",
            "Hypoxic preconditioning",
            "Mesenchymal stem cells",
            "Myocardial infarction"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "Department of Cardiology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China."
            },
            {
                "name": "Chao Yang",
                "org": "Department of Blood Transfusion, The General Hospital of the PLA Rocket Force, Beijing, 100088, China."
            },
            {
                "name": "Mingzhi Shen",
                "org": "Department of Cardiology, Hainan Branch of PLA General Hospital, Sanya, 572013, China."
            },
            {
                "name": "Ming Yang",
                "org": "School of Basic Medical Sciences, Taishan Medical University, Taian, Shandong, 271000, China."
            },
            {
                "name": "Zhitao Jin",
                "org": "Department of Cardiology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China."
            },
            {
                "name": "Liping Ding",
                "org": "Department of Cardiology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China."
            },
            {
                "name": "Wei Jiang",
                "org": "Department of Cardiology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China."
            },
            {
                "name": "Junke Yang",
                "org": "Department of Cardiology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China."
            },
            {
                "name": "Haixu Chen",
                "org": "Core Laboratory of Translational Medicine, Institute of Geriatrics, PLA general Hospital, Beijing, 100853, China."
            },
            {
                "name": "Feng Cao",
                "org": "Department of Cardiology, The General Hospital of Chinese People's Liberation Army, Beijing, 100853, China. wind8828@gmail.com."
            },
            {
                "name": "Taohong Hu",
                "org": "Department of Cardiology, The General Hospital of the PLA Rocket Force, Beijing, 100088, China. Hutaohong2010@163.com."
            }
        ],
        "venue": "Stem cell research & therapy",
        "year": 2017
    },
    "Gcwdqzsq": {
        "id": "Gcwdqzsq",
        "title": "AS-5: Long-Term Myocardial Functional Improvement after Autologous Bone Marrow Mononuclear Cell Transplantation in Patients with ST-Segment Elevation Myocardial Infarction (STEMI): 4-Years Follow-Up",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Xijing Hosp, Xian, Peoples R China"
            },
            {
                "name": "Dong Dong Sun",
                "org": "Xijing Hosp, Xian, Peoples R China"
            },
            {
                "name": "Cheng Xiang Li",
                "org": "Xijing Hosp, Xian, Peoples R China"
            },
            {
                "name": "Kazim Narsinh",
                "org": "Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA"
            },
            {
                "name": "Wenyi Guo",
                "org": "Xijing Hosp, Xian, Peoples R China"
            },
            {
                "name": "Xue Li",
                "org": "Xijing Hosp, Xian, Peoples R China"
            },
            {
                "name": "Xu Yang Fen",
                "org": "Xijing Hosp, Xian, Peoples R China"
            },
            {
                "name": "Haichang Wang",
                "org": "Xijing Hosp, Xian, Peoples R China"
            }
        ],
        "venue": "AMERICAN JOURNAL OF CARDIOLOGY",
        "year": 2009
    },
    "Y9moQH6G": {
        "id": "Y9moQH6G",
        "title": "Precise theranostic nanomedicines for inhibiting vulnerable atherosclerotic plaque progression through regulation of vascular smooth muscle cell phenotype switching.",
        "abstract": "Coronary heart disease is a prevalent and fatal killer caused by vulnerable atherosclerotic plaques (VASPs). However, the precise detection and treatment of VASPs remains a difficult challenge. Here, we present the development of noninvasive human serum albumin (HSA)-based theranostic nanomedicines (NMs) for the specific diagnosis and effective therapy of VASPs. Methods: The ICG/SRT@HSA-pept NMs were formulated to contain payloads of the near-infrared (NIR) fluorescent dye indocyanine green (ICG) and the sirtuin 1 (Sirtl) activator SRT1720, and modified with a peptide moiety targeting osteopontin (OPN). The in vivo atherosclerotic mouse model was established with the high-fat diet (HFD). The in vitro vascular smooth muscle cells (VSMCs) phenotypic switching was induced using the ox-LDL stimulation. Results: Due to the overexpression of OPN in activated VSMCs and VASPs, the targeted NMs specifically accumulated within the VASPs region after intravenous injection into the atherosclerotic mice, achieving the precise detection of VASPs. In addition, in the presence of SRT1720, the NMs could activate intracellular Sirtl and activate an antiatherogenesis effect by inhibiting the phenotypic switching of VSMCs, which is an essential contributor to the vulnerability and progression of atherosclerotic plaques. After therapeutic administration of the ICG/SRT@HSA-pept NMs for two weeks, the physiological sizes and plaque compositions of VASPs were markedly improved. Furthermore, ICG/SRT@HSA-pept NMs-treated mice presented a more favorable plaque phenotype than that was observed in free SRT1720-treated mice, suggesting the enhanced delivery of pharmaceutical agents to the atherosclerotic lesions and improved therapeutic efficacy of NMs compared with free SRT1720. Conclusions: The theranostic ICG/SRT@HSA-pept NMs showed great potential for the precise identification and targeted treatment of atherosclerotic diseases.",
        "keywords": [
            "atherosclerosis",
            "theranostic nanomedicines",
            "sirtuin 1",
            "osteopontin",
            "vascular smooth muscle cells"
        ],
        "authors": [
            {
                "name": "Sai Ma",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Seyed Mohammad Motevalli",
                "org": "Chinese Acad Sci, Lab Controllable Nartopharmaceut, Ctr Excellence Nanosci, Beijing 100190, Peoples R China"
            },
            {
                "name": "Jiangwei Chen",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Meng-Qi Xu",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Yabin Wang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Jing Feng",
                "org": "Jinling Hosp, Dept Emergency Med, Nanjing 210000, Jiangsu, Peoples R China"
            },
            {
                "name": "Ya Qiu",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Dong Han",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Miaomiao Fan",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Meiling Ding",
                "org": "Fourth Mil Med Univ, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Li Fan",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China"
            },
            {
                "name": "Weisheng Guo",
                "org": "Chinese Acad Sci, Lab Controllable Nartopharmaceut, Ctr Excellence Nanosci, Beijing 100190, Peoples R China"
            },
            {
                "name": "Xing-Jie Liang",
                "org": "Chinese Acad Sci, Lab Controllable Nartopharmaceut, Ctr Excellence Nanosci, Beijing 100190, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            }
        ],
        "venue": "THERANOSTICS",
        "year": 2018
    },
    "8Qm7f0Ab": {
        "id": "8Qm7f0Ab",
        "title": "Abstract 9321: Selective Inhibition of Inositol Hexakisphosphate Kinases Enhances Mesenchymal Stem Cell Engraftment and Improves Therapeutic Efficacy for Myocardial Infarction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhang zheng",
                "org": ""
            },
            {
                "name": "xue gao",
                "org": ""
            },
            {
                "name": "haichang wang",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2013
    },
    "HWsgFjwu": {
        "id": "HWsgFjwu",
        "title": "INOSITOL HEXAKISPHOSPHATE KINASES’ (IP6KS) SELECTIVE INHIBITION ENHANCES MESENCHYMAL STEM CELLS ENGRAFTMENT AND IMPROVES THERAPEUTIC EFFICACY FOR MYOCARDIAL INFARCTION",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng cao",
                "org": "Xijing Hospital, Xi an, People's Republic of China"
            },
            {
                "name": "zheng zhang",
                "org": "Xijing Hospital, Xi an, People's Republic of China"
            },
            {
                "name": "dongdong sun",
                "org": "Xijing Hospital, Xi an, People's Republic of China"
            },
            {
                "name": "haichang wang",
                "org": "Xijing Hospital, Xi an, People's Republic of China"
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2013
    },
    "NcUCm0ge": {
        "id": "NcUCm0ge",
        "title": "Abstract 16413: Molecular Imaging of Apelin on Enhancing Survival of Mesenchymal Stem Cells in Hindlimb Mice by Differential Regulation of Autophagy",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Dong Liang",
                "org": ""
            },
            {
                "name": "Ke Ma",
                "org": ""
            },
            {
                "name": "Xiujuan Li",
                "org": ""
            },
            {
                "name": "Yabin Wang",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2013
    },
    "3lHprKh9": {
        "id": "3lHprKh9",
        "title": "Comparison of Sonazoid and Sonovue in the Diagnosis of Focal Liver Lesions: A Preliminary Study.",
        "abstract": "Objective This study aimed to compare the efficacy of Sonazoid and SonoVue in subjects with focal liver lesions. Methods The patients who had untreated focal solid liver lesions confirmed by B-mode ultrasonography were eligible for the study. The target lesion and whole liver were scanned by gray scale ultrasonography; then, contrast-enhanced ultrasonography was performed, and the results were evaluated blindly. The main end point was accuracy improvement with postcontrast versus precontrast ultrasound examination for diagnosis of the target lesion of interest as malignant or benign against the reference standard. Results There were 65 patients with 65 hepatic tumors enrolled in the study. The improvement of diagnostic accuracy was 0.30 in the Sonazoid group and 0.16 in the SonoVue group (95% confidence interval, -0.828-0.168; P = .24). Using 20% as the noninferiority margin, the upper limit of the 95% confidence interval (0.168) was less than 0.20. The number of lesions detected during the whole-liver scanning in the Sonazoid group was significantly more than that detected in the SonoVue group (P = .024). Conclusion The diagnosis value of Sonazoid is noninferior to SonoVue, and this new contrast agent can improves the whole-liver image quality.",
        "keywords": [
            "detection efficacy",
            "diagnostic efficacy",
            "focal liver lesion",
            "Sonazoid",
            "SonoVue"
        ],
        "authors": [
            {
                "name": "Hong-Yan Zhai",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Intervent Ultrasound, 28 Fuxing Rd, Beijing 100853, Peoples R China"
            },
            {
                "name": "Ping Liang",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Intervent Ultrasound, 28 Fuxing Rd, Beijing 100853, Peoples R China"
            },
            {
                "name": "Jie Yu",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Intervent Ultrasound, 28 Fuxing Rd, Beijing 100853, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Cardiovasc, Beijing, Peoples R China"
            },
            {
                "name": "Ming Kuang",
                "org": "Sun Yat Sen Univ, Affiliated Hosp 1, Dept Med Ultrasound, Div Intervent Ultrasound, Guangzhou, Guangdong, Peoples R China"
            },
            {
                "name": "Feng-Yong Liu",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Intervent Ultrasound, 28 Fuxing Rd, Beijing 100853, Peoples R China"
            },
            {
                "name": "Fang-Yi Liu",
                "org": "Gen Hosp Chinese Peoples Liberat Army, Dept Intervent Radiol, Beijing, Peoples R China"
            },
            {
                "name": "Xin-Yuan Zhu",
                "org": "Tianjin Med Univ, Dept Cardiovasc Surg, Gen Hosp, Tianjin, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF ULTRASOUND IN MEDICINE",
        "year": 2019
    },
    "ST6tdPSq": {
        "id": "ST6tdPSq",
        "title": "MOLECULAR IMAGING OF ATHEROSCLEROTIC PLAQUE VIA PROFILIN-1 ANTIBODY LABELLED QUATERNISED CHITOSAN ENCAPSULATED MAGNETIC NANOPARTICLES",
        "abstract": "",
        "keywords": [
            "epidemiology"
        ],
        "authors": [
            {
                "name": "yabin wang",
                "org": "fourth military medical university"
            },
            {
                "name": "hongbin deng",
                "org": ""
            },
            {
                "name": "tao su",
                "org": "fourth military medical university"
            },
            {
                "name": "feng cao",
                "org": "fourth military medical university"
            }
        ],
        "venue": "Heart",
        "year": 2012
    },
    "W0lbE5eG": {
        "id": "W0lbE5eG",
        "title": "Predictive value of P wave dispersion on paroxysmal atrial fibrillation of patients with essential hypertension",
        "abstract": "Objective:To investigate the predictive value of P wave dispersion(Pd) on atrial fibrillation(AF) of patients with essential hypertension.Methods:Ninety-five patients were divided into two groups,including the essential hypertensive patients with(the observation group,n=48) or without AF(the control group,n=47).The maximum P wave duration (Pmax),the minimum P wave duration(Pmin) and Pd were measured in both groups through the 12-lead surface electrocardiogram.Left atrial dimension (LAD) and left ventricular ejection fraction (LVEF) were also measured by echocardiography.Pmax,Pmin,Pd,LAD and LVEF were compared between the two groups.Results:Compared with the control group,the observation group was significantly increased Pmax and Pd(P<0.05),between the two groups Pmin,LAD and LVEF were no significant differences(P>0.05),Pmax>110 ms + Pd≥40 ms predict the sensitivity of atrial fibrillation and the negative predictive value decreased,but the specificity and positive predictive value increase.Conclusion:Pd is a significant predictor on AF in patients with essential hypertension.Its predictive value is higher when combined Pd and Pmax.",
        "keywords": [
            "Atrial fibrillation",
            "P wave dispersion",
            "Hypertension"
        ],
        "authors": [
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,the People's Hospital of Wuhan University,Hubei Province,Wuhan ,China"
            },
            {
                "name": "LI Xia",
                "org": "Department of Cardiology,the People's Hospital of Wuhan University,Hubei Province,Wuhan ,China"
            }
        ],
        "venue": "China Modern Medicine",
        "year": 2010
    },
    "wUPX0hy0": {
        "id": "wUPX0hy0",
        "title": "Effects of carvedilol on atrial gap junctional remodeling after chronic left ventricular myocardial infarction",
        "abstract": "Objective: To investigate the effects of Carvedilol on atrial gap junctional remodeling in a rabbit model of chronic left ventricular myocardial infarction (MI). Methods: Thirty rabbits were randomly divided into three groups: control group (n=10, thoracotomy, left anterior descending artery was not ligated) and MI (n = 10, thoracotomy + MI, left anterior descending artery was ligated) group, and Carvedilol group (n = 10). The rabbits in the Carvedilol group received oral Carvedilol [5 mg/(kg · d)] for eight weeks. The rabbits in the other two groups received a matching saline. Eight weeks after operation, distribution of atrial connexin 40(Cx40) and its protein level were studied by immunohistochemistry and Western blot. Results: In MI group, atrial Cx40 level of left atrial appendage decreased significantly than that in control group (P<0. 01). The distribution Cx40 was changed. The side-to-side junctions increased, while the end-to-end junctions decreased. Atrial Cx40 in MI group was highly heterogeneous. In the Carvedilol group, the atrial Cx40 level increased significantly than that in MI group (P<0.05). Conclusion: Chronic left ventricular myocardial infarction can results in atrial Cx40 remodeling. Carvedilol can attenuate the Cx40 remodeling effectively.",
        "keywords": [
            "Atrial fibrillation",
            "Carvedilol",
            "Gap junction",
            "Myocardial infarction"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Congxin Huang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Hong Jiang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Xia Li",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "MingWei Bao",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Yanhong Tang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            }
        ],
        "venue": "Medical Journal of Wuhan University",
        "year": 2007
    },
    "Nfaci9bk": {
        "id": "Nfaci9bk",
        "title": "Radiofrequency catheter ablation of premature ventricular contractions in hypertensive patients: A medium and long-term follow-up",
        "abstract": "Objective: To evaluate the medium and long-term effects of radiofrequency catheter ablation (RFCA) on the hyptensive patients with premature ventricular contractions (PVCs). Methods: Radiofrequency catheter ablation (RFCA) was performed in 27 patients. The 24-hour ambulatory electrocardiographic monitoring, echocardiography, quality of life, healthcare resources utilization and cost were assessed at a screening visit and 3 and 12 months after RFCA. Patients were treated with RFCA and followed up over 6 months as outpatients. Cardiac troponin I(cTnI) level was repeatedly checked before and after RFCA. Results: Patients' PVCs were dramatically decreased to less than 1 000 beats per day by successful RFCA, left ventricular (LV) end-diastolic dimension (LVEDd) and end-systolic dimension (LVESd) measured by echocardiography had significant changes during the follow-up period (LV dimensions decreased significantly and LVEF increased significantly during the follow-up period as following: LVEDd: (44. 40 ± 5. 07) to (42.44 ± 5.60)mm, P<0. 01; LVESd: (33.07 ± 2.30) to (31. 66 ± 2. 20) mm, P<0. 01; LVEF: (56.07 ± 1.59) to (59.92 ± 1.49)%, P<0. 01); cTnI level: (0.15 ± 0. 19) to (1. 09 ± 0. 40)μg/L, P<0. 01, but still in normal range. This resulted in a significant improvement in quality of life at 3 and 12 months after the procedure. There were no major complications related to the procedure. It also reduced healthcare resource utilization and cost. Conclusion: Radiofrequency catheter ablation is a safe and effective treatment for hypertensive patients with premature ventricular contractions, and it is a viable alternation to drugs in the presence of disabling symptoms, and a protective method for hypertensive patients.",
        "keywords": [
            "Hypertension",
            "Premature ventricular contractions",
            "Radiofrequency catheter ablation"
        ],
        "authors": [
            {
                "name": "Jinjun Liang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Congxin Huang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Bo Yang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Hong Jiang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Jun Wan",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "He Huang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Yanhong Tang",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Gang Wu",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            },
            {
                "name": "Feng Cao",
                "org": "Hubei General Hospital(Wuhan University,Renmin Hospital of Wuhan University),Wuhan,China"
            }
        ],
        "venue": "Medical Journal of Wuhan University",
        "year": 2007
    },
    "arHqehlO": {
        "id": "arHqehlO",
        "title": "Effects of irbesartan on atrial cell electrophysiology.",
        "abstract": "Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice.~1  Its incidence increases with age and the presence of structural heart disease. It is a major cause of stroke, especially in the elderly. It has been shown that angiotensin converting enzyme inhibitor (ACEI) can reduce the incidence of AF after acute myocardial infarction.~2  Several studies have shown that activation of the rennin-angiotensin system is associated with the mechanisms of AF. Irbesartan is a long-acting angiotensin Ⅱ type 1 receptor antagonist used widely in the treatment of hypertension.~3  In recent years, it has been demonstrated that patients treated with amiodarone plus irbesartan had a lower rate of recurrence of atrial fibrillation than did patients treated with amiodarone alone.~4  These findings suggest that the inhibition of angiotensin Ⅱ may prevent AF, but its underlying electrophysiological mechanisms are obscure. The purpose of this study is to investigate the effects of irbesartan on atrial cell electrophysiology.",
        "keywords": [
            "irbesartan · arrhythmia · electrophysiology · ion channels"
        ],
        "authors": [
            {
                "name": "Cong-Xin Huang",
                "org": "Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China."
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Hong Jiang",
                "org": ""
            },
            {
                "name": "Teng Wang",
                "org": ""
            },
            {
                "name": "Xia Li",
                "org": ""
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2005
    },
    "D9ZxHIae": {
        "id": "D9ZxHIae",
        "title": "The beta-adrenergic blocker carvedilol restores L-type calcium current in a myocardial infarction model of rabbit.",
        "abstract": "Carvedilol, an antagonist of alpha1- and beta-adrenergic receptors, has shown efficacy in reducing all-cause death and arrhythmia death for ischemic heart disease and congestive heart failure in several large-scale trials. It has been found to prevent ventricular remodeling, and recently was reported to reverse down-regulation of Na+ channel in a chronic heart failure model. This study was conducted to investigate whether carvedilol could reverse the ion remodeling in a myocardial infarction model of rabbit.After the procedure of coronary ligation, animals were randomized to placebo or carvedilol treatment (5 mg/kg). Action potentials, L-type calcium current (Ica L) and the effect of isoproterenol stimulation on Ica L were measured using whole-cell patch method. Evaluation of the expression of calcium channel subunits was carried out by RT-PCR and Western blot.The results indicate that mean peak Ica L densities (pA/pF) at +10 mV was reduced in postinfarction myocytes (5.33 +/- 0.45, n = 25) compared to sham myocytes (6.52 +/- 0.21, n = 20). Treatment of myocardial infarction rabbits with carvedilol could restore it partially (5.91 +/- 0.39, n = 20, P < 0.05). However, steady-state activation parameters were similar in three groups. With stimulation by isoproterenol (1 micromol/L) Ica L increased in all three groups, but the increase was smaller in postinfarction myocytes. mRNA levels of calcium channel subunit CaA1 gene was decreased but CaB2a, CaB2b and CaB3 mRNA levels did not change after MI. Corresponding change in CaA1 protein was also observed.The results demonstrate that carvedilol restores Ica L density and reverse the downregulation of CaA1 postinfarction.",
        "keywords": [
            "myocardial infarction · calcium channel · ventricular remodeling · beta-adrenergic blockers"
        ],
        "authors": [
            {
                "name": "Xia Li",
                "org": "Department of Cardiology, People's Hospital of Wuhan University, Wuhan 430060, China. summermm@vip.sina.com"
            },
            {
                "name": "Cong-Xin Huang",
                "org": ""
            },
            {
                "name": "Hong Jiang",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Teng Wang",
                "org": ""
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2005
    },
    "v0dYWiA5": {
        "id": "v0dYWiA5",
        "title": "Translation of duck hepatitis B virus reverse transcriptase by ribosomal shunting.",
        "abstract": "The duck hepatitis B virus (DHBV) polymerase (P) is translated by de novo initiation from a downstream open reading frame (ORF) that partially overlaps the core (C) ORF on the bicistronic pregenomic RNA (pgRNA). The DHBV P AUG is in a poor context for translational initiation and is preceded by 14 AUGs that could intercept scanning ribosomes, yet P translation is unanticipatedly rapid. Therefore, we assessed C and P translation in the context of the pgRNA. Mutating the upstream C ORF revealed that P translation was inversely related to C translation, primarily due to occlusion of P translation by ribosomes translating C. Translation of the pgRNA was found to be cap dependent, because inserting a stem-loop (BamHI-SL) that blocked >90% of scanning ribosomes at the 5' end of the pgRNA greatly inhibited C and P synthesis. Neither mutating AUGs between the C and P start sites in contexts similar to that of the P AUG nor blocking ribosomal scanning by inserting the BamHI-SL between the C and P start codons greatly altered P translation, indicating that most ribosomes that translate P do not scan through these sequences. Finally, optimizing the P AUG context did not increase P translation. Therefore, the majority of the ribosomes that translate P are shunted from a donor region near the 5' end of the pgRNA to an acceptor site at or near the P AUG, and the shunt acceptor sequences may augment initiation at the P AUG.",
        "keywords": [
            "open reading frames",
            "reverse transcriptase",
            "ribosomes",
            "protein biosynthesis"
        ],
        "authors": [
            {
                "name": "Nandini Sen",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "John E Tavis",
                "org": ""
            }
        ],
        "venue": "Journal of virology",
        "year": 2004
    },
    "BbxPb4f0": {
        "id": "BbxPb4f0",
        "title": "Multiple effects of silymarin on the hepatitis C virus lifecycle.",
        "abstract": "Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV) infection, both in vitro and in vivo. In the current study, we further characterized silymarin's antiviral actions. Silymarin had antiviral effects against hepatitis C virus cell culture (HCVcc) infection that included inhibition of virus entry, RNA and protein expression, and infectious virus production. Silymarin did not block HCVcc binding to cells but inhibited the entry of several viral pseudoparticles (pp), and fusion of HCVpp with liposomes. Silymarin but not silibinin inhibited genotype 2a NS5B RNA-dependent RNA polymerase (RdRp) activity at concentrations 5 to 10 times higher than required for anti-HCVcc effects. Furthermore, silymarin had inefficient activity on the genotype 1b BK and four 1b RDRPs derived from HCV-infected patients. Moreover, silymarin did not inhibit HCV replication in five independent genotype 1a, 1b, and 2a replicon cell lines that did not produce infectious virus. Silymarin inhibited microsomal triglyceride transfer protein activity, apolipoprotein B secretion, and infectious virion production into culture supernatants. Silymarin also blocked cell-to-cell spread of virus.Although inhibition of in vitro NS5B polymerase activity is demonstrable, the mechanisms of silymarin's antiviral action appear to include blocking of virus entry and transmission, possibly by targeting the host cell.",
        "keywords": [],
        "authors": [
            {
                "name": "Jessica Wagoner",
                "org": ""
            },
            {
                "name": "Amina Negash",
                "org": ""
            },
            {
                "name": "Olivia J Kane",
                "org": ""
            },
            {
                "name": "Laura E Martinez",
                "org": ""
            },
            {
                "name": "Yaakov Nahmias",
                "org": ""
            },
            {
                "name": "Nigel Bourne",
                "org": ""
            },
            {
                "name": "David M Owen",
                "org": ""
            },
            {
                "name": "Joe Grove",
                "org": ""
            },
            {
                "name": "Claire Brimacombe",
                "org": ""
            },
            {
                "name": "Jane A McKeating",
                "org": ""
            },
            {
                "name": "Eve-Isabelle Pécheur",
                "org": ""
            },
            {
                "name": "Tyler N Graf",
                "org": ""
            },
            {
                "name": "Nicholas H Oberlies",
                "org": ""
            },
            {
                "name": "Volker Lohmann",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "John E Tavis",
                "org": ""
            },
            {
                "name": "Stephen J Polyak",
                "org": ""
            }
        ],
        "venue": "Hepatology (Baltimore, Md.)",
        "year": 2010
    },
    "kjFlD7n2": {
        "id": "kjFlD7n2",
        "title": "Combining genetic and biochemical approaches to identify functional molecular contact points",
        "abstract": "Protein-protein interactions are required for many viral and cellular functions and are potential targets for novel therapies.\n Here we detail a series of genetic and biochemical techniques used in combination to find an essential molecular contact point\n on the duck hepatitis B virus polymerase. These techniques include differential immunoprecipitation, mutagenesis and peptide\n competition. The strength of these techniques is their ability to identify contact points on intact proteins or protein complexes\n employing functional assays. This approach can be used to aid identification of putative binding sites on proteins and protein\n complexes which are resistant to characterization by other methods.",
        "keywords": [
            "genetics",
            "binding site",
            "bioinformatics",
            "protein complex",
            "biomedical research",
            "protein protein interaction"
        ],
        "authors": [
            {
                "name": "Matthew P. Badtke",
                "org": "Saint Louis University School of Medicine Department of Molecular Microbiology and Immunology 1402 S. Grand Blvd. 63104 St. Louis MO USA"
            },
            {
                "name": "Feng Cao",
                "org": "Saint Louis University School of Medicine Department of Molecular Microbiology and Immunology 1402 S. Grand Blvd. 63104 St. Louis MO USA"
            },
            {
                "name": "John E. Tavis",
                "org": "Saint Louis University School of Medicine Department of Molecular Microbiology and Immunology and Saint Louis University Liver Center 63104 St. Louis MO USA"
            }
        ],
        "venue": "Biological Procedures Online",
        "year": 2006
    },
    "gEEc3YE8": {
        "id": "gEEc3YE8",
        "title": "Herpes simplex virus 2 UL13 protein kinase disrupts nuclear lamins",
        "abstract": "Herpesviruses must cross the inner nuclear membrane and underlying lamina to exit the nucleus. HSV-1 US3 and PKC can phosphorylate lamins and induce their dispersion but do not elicit all of the phosphorylated lamin species produced during infection. UL13 is a serine threonine protein kinase conserved among many herpesviruses. HSV-1 UL13 phosphorylates US3 and thereby controls UL31 and UL34 nuclear rim localization, indicating a role in nuclear egress. Here, we report that HSV-2 UL13 alone induced conformational changes in lamins A and C and redistributed lamin B1 from the nuclear rim to intranuclear granular structures. HSV-2 UL13 directly phosphorylated lamins A, C, and B1 in vitro , and the lamin A1 tail domain. HSV-2 infection recapitulated the lamin alterations seen upon expression of UL13 alone, and other alterations were also observed, indicating that additional viral and/or cellular proteins cooperate with UL13 to alter lamins during HSV-2 infection to allow nuclear egress.",
        "keywords": [
            "Nuclear",
            "Phosphorylation",
            "HSV-2",
            "UL13",
            "Lamin",
            "Egress",
            "Herpes simplex virus"
        ],
        "authors": [
            {
                "name": "Gina L. Cano-Monreal",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Blvd., St. Louis, MO 63104, USA."
            },
            {
                "name": "Kristine M. Wylie",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Blvd., St. Louis, MO 63104, USA"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Blvd., St. Louis, MO 63104, USA"
            },
            {
                "name": "John E. Tavis",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 South Grand Blvd., St. Louis, MO 63104, USA"
            },
            {
                "name": "Lynda A. Morrison",
                "org": ""
            }
        ],
        "venue": "Virology",
        "year": 2009
    },
    "9YaPVri9": {
        "id": "9YaPVri9",
        "title": "Pre-P is a secreted glycoprotein encoded as an N-terminal extension of the duck hepatitis B virus polymerase gene.",
        "abstract": "The duck hepatitis B virus (DHBV) pregenomic RNA is a bicistronic mRNA encoding the core and polymerase proteins. Thirteen AUGs (C2 to C14) and 10 stop codons (S1 to S10) are located between the C1 AUG for the core protein and the P1 AUG that initiates polymerase translation. We previously found that the translation of the DHBV polymerase is initiated by ribosomal shunting. Here, we assessed the biosynthetic events after shunting. Translation of the polymerase open reading frame was found to initiate at the C13, C14, and P1 AUGs. Initiation at the C13 AUG occurred through ribosomal shunting because translation from this codon was cap dependent but was insensitive to blocking ribosomal scanning internally in the message. C13 and C14 are in frame with P1, and translation from these upstream start codons led to the production of larger isoforms of P. We named these isoforms \"pre-P\" by analogy to the pre-C and pre-S regions of the core and surface antigen open reading frames. Pre-P was produced in DHBV16 and AusDHBV-infected duck liver and was predicted to exist in 80% of avian hepadnavirus strains. Pre-P was not encapsidated into DHBV core particles, and the viable strain DHBV3 cannot make pre-P, so it is not essential for viral replication. Surprisingly, we found that pre-P is an N-linked glycoprotein that is secreted into the medium of cultured cells. These data indicate that DHBV produces an additional protein that has not been previously reported. Identifying the role of pre-P may improve our understanding of the biology of DHBV infection.",
        "keywords": [
            "glycoproteins",
            "viral replication",
            "protein biosynthesis",
            "isoenzymes",
            "messenger rna",
            "genes",
            "codons",
            "glycoprotein",
            "chickens",
            "n terminal",
            "ribosomes",
            "translation",
            "cell line",
            "open reading frame",
            "open reading frames"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Catherine A Scougall",
                "org": ""
            },
            {
                "name": "Allison R Jilbert",
                "org": ""
            },
            {
                "name": "John E Tavis",
                "org": ""
            }
        ],
        "venue": "Journal of virology",
        "year": 2009
    },
    "n3vBD9PV": {
        "id": "n3vBD9PV",
        "title": "Detection and characterization of cytoplasmic hepatitis B virus reverse transcriptase.",
        "abstract": "It was recently found that the Duck hepatitis B virus (DHBV) reverse transcriptase is primarily a non-encapsidated cytoplasmic molecule that is rapidly translated and has a very short half-life. Here, a non-encapsidated reverse transcriptase from the human Hepatitis B virus (HBV) was characterized. HBV polymerase accumulated in the cytoplasm in a manner similar to non-encapsidated DHBV polymerase. However, the HBV polymerase accumulated at an apparently lower concentration and had a longer half-life than the DHBV enzyme, and it displayed no evidence of the post-translational modifications observed for DHBV. Unlike the DHBV polymerase, immunofluorescence detection of the HBV polymerase in cells was suppressed by the core protein, and this suppression occurred independently of encapsidation. This implies an interaction between the polymerase and core in addition to encapsidation, but the polymerase and core did not co-immunoprecipitate, so the interaction might not be direct. These data indicate that production of cytoplasmic, non-encapsidated polymerase is conserved among the hepadnaviral genera. Furthermore, conservation of the cytoplasmic form of the polymerase suggests that it might have function(s) in virus replication or pathology beyond copying the viral genome.",
        "keywords": [],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "John E Tavis",
                "org": ""
            }
        ],
        "venue": "The Journal of general virology",
        "year": 2004
    },
    "dVAnbsP4": {
        "id": "dVAnbsP4",
        "title": "An interdomain RNA binding site on the hepadnaviral polymerase that is essential for reverse transcription",
        "abstract": "The T3 motif on the duck hepatitis B virus reverse transcriptase (P) is proposed to be a binding site essential for viral replication, but its ligand and roles in DNA synthesis are unknown. Here, we found that T3 is needed for P to bind the viral RNA, the first step in DNA synthesis. A second motif, RT-1, was predicted to assist T3. T3 and RT-1 appear to form a composite RNA binding site because mutating T3 and RT-1 had similar effects on RNA binding, exposure of antibody epitopes on P, and DNA synthesis. The T3 and RT-1 motifs bound RNA non-specifically, yet they were essential for specific interactions between P and the viral RNA. This implies that specificity for the viral RNA is provided by a post-binding step. The T3:RT-1 motifs are conserved with the human hepatitis B virus and may be an attractive target for novel antiviral drug development.",
        "keywords": [],
        "authors": [
            {
                "name": "Matthew P. Badtke",
                "org": ""
            },
            {
                "name": "Irfan Khan",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, MO, USA"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, MO, USA"
            },
            {
                "name": "Jianming Hu",
                "org": "Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA, USA"
            },
            {
                "name": "John E. Tavis",
                "org": ""
            }
        ],
        "venue": "Virology",
        "year": 2009
    },
    "PnVEJyls": {
        "id": "PnVEJyls",
        "title": "Identification of an essential molecular contact point on the duck hepatitis B virus reverse transcriptase.",
        "abstract": "The hepadnaviral polymerase (P) functions in a complex with viral nucleic acids and cellular chaperones. To begin to identify contacts between P and its partners, we assessed the exposure of the epitopes of six monoclonal antibodies (MAbs) to the terminal protein domain of the duck hepatitis B virus P protein in a partially denaturing buffer (RIPA) and a physiological buffer (IPP150). All MAbs immunoprecipitated in vitro translated P well in RIPA, but three immunoprecipitated P poorly in IPP150. Therefore, the epitopes for these MAbs were obscured in the native conformation of P but were exposed when P was in RIPA. Epitopes for MAbs that immunoprecipitated P poorly in IPP150 were between amino acids (aa) 138 and 202. Mutation of a highly conserved motif within this region (T3; aa 176 to 183) improved the immunoprecipitation of P by these MAbs and simultaneously inhibited DNA priming by P. Peptides containing the T3 motif inhibited DNA priming in a dose-dependent manner, whereas eight irrelevant peptides did not. T3 function appears to be conserved among the hepadnaviruses because mutating T3 ablated DNA synthesis in both duck hepatitis B virus and hepatitis B virus. These results indicate that (i) the conserved T3 motif is a molecular contact point whose ligand can be competed by soluble T3 peptides, (ii) the occupancy of T3 obscures the epitopes for three MAbs, and (iii) proper occupancy of T3 by its ligand is essential for DNA priming. Therefore, small-molecule ligands that compete for binding to T3 with its natural ligand could form a novel class of antiviral drugs.",
        "keywords": [
            "amino acid sequence",
            "reverse transcriptase",
            "dna",
            "binding sites",
            "epitopes"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Matthew P Badtke",
                "org": ""
            },
            {
                "name": "Lisa M Metzger",
                "org": ""
            },
            {
                "name": "Ermei Yao",
                "org": ""
            },
            {
                "name": "Babatunde Adeyemo",
                "org": ""
            },
            {
                "name": "Yunhao Gong",
                "org": ""
            },
            {
                "name": "John E Tavis",
                "org": ""
            }
        ],
        "venue": "Journal of virology",
        "year": 2005
    },
    "qf752Jyi": {
        "id": "qf752Jyi",
        "title": "Suppression of mRNA accumulation by the duck hepatitis B virus reverse transcriptase.",
        "abstract": "Hepadnaviruses establish chronic liver infections, but the mechanisms of persistence and immune evasion are poorly understood. We previously found that the duck hepatitis B virus (DHBV) and hepatitis B virus reverse transcriptases (P protein) unexpectedly accumulate in the cytoplasm where they could affect function(s) beyond viral DNA synthesis, such as gene expression. Therefore, we measured effects of DHBV P on gene expression from reporter constructs and the viral genome. P reduced reporter expression at the mRNA level to approximately 30-40%, independent of reporter tested. Accumulation of the viral pregenomic RNA from its native promoter was suppressed three-to four-fold by P, and accumulation of the capsid protein and intracellular core particles was similarly suppressed because the pregenomic RNA encodes the capsid protein. Therefore, suppression of the pregenomic RNA by DHBV P creates a negative feedback loop to limit viral antigen accumulation and replication, possibly contributing to maintenance of chronic infection.",
        "keywords": [
            "reverse transcriptase",
            "mrna",
            "viral replication",
            "duck hepatitis b virus",
            "polymerase",
            "gene regulation",
            "chronic infection"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1402 S. Grand Blvd., St. Louis, MO 63104, USA"
            },
            {
                "name": "John E Tavis",
                "org": ""
            }
        ],
        "venue": "Virology",
        "year": 2006
    },
    "xy5erXV1": {
        "id": "xy5erXV1",
        "title": "An identity based universal designated verifier signature scheme secure in the standard model",
        "abstract": "Universal designated verifier signature was first introduced by Steinfeld, Bull, Wang and Pieprzyk in Asiacrypt 2003. In the universal designated verifier signature scheme, any holder of a signature can designate the signature to any desired designated verifier, such that only the designated verifier will believe that the signature holder holds a valid signature. In SecUbiq'05 [Zhang Fangguo, Susilo Willy, Mu Yi, Chen Xiaofeng, 2005. Identity-based universal designated verifier signatures. In: The First International Workshop on Security in Ubiquitous Computing Systems, Nagasaki, Japan, LNCS 3823. Springer-Verlag, Berlin, pp. 825-834] first extended this notion to the identity based setting and proposed two identity based universal designated verifier signature schemes. However, the security of their scheme is based on the random oracle model. Up to now, there is no provably secure identity based universal designated verifier signature scheme in the standard model. In this paper, we propose the first identity based universal designated verifier signature scheme whose security can be proven in the standard model based on the hardness of the computational Diffie-Hellman (CDH) problem.",
        "keywords": [
            "provably secure",
            "first international workshop",
            "signature holder",
            "standard model",
            "random oracle model",
            "chen xiaofeng",
            "valid signature",
            "provably secure identity",
            "identity based",
            "universal designated verifier signature",
            "verifier signature scheme",
            "verifier signature",
            "mu yi",
            "ubiquitous computing",
            "universal design",
            "provable security"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"
            },
            {
                "name": "Zhenfu Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"
            }
        ],
        "venue": "Journal of Systems and Software",
        "year": 2009
    },
    "x348r0eL": {
        "id": "x348r0eL",
        "title": "A secure identity-based proxy multi-signature scheme",
        "abstract": "In a proxy multi-signature scheme, a designated proxy signer can generate the signature on behalf of a group of original signers. To our best knowledge, most of existing proxy multi-signature schemes are proposed in public key infrastructure setting, which may be the bottleneck due to its complexity. To deduce the complexity, several proxy multi-signature schemes are proposed in the ID-based setting. However, no formal definitions on ID-based proxy are proposed until now. To fill the gap, this paper proposes the formal definition. Furthermore, we present a proven secure ID-based proxy multi-signature scheme, which is more efficient than existing schemes in term of computational cost.",
        "keywords": [
            "public key infrastructure setting",
            "id-based proxy",
            "best knowledge",
            "id-based setting",
            "proxy signer",
            "computational cost",
            "formal definition",
            "secure identity-based proxy multi-signature",
            "multi-signature scheme",
            "proxy multi-signature scheme",
            "proven secure id-based proxy",
            "security model",
            "public key infrastructure",
            "digital signature",
            "provable security"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"
            },
            {
                "name": "Zhenfu Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"
            }
        ],
        "venue": "Inf. Sci.",
        "year": 2009
    },
    "DLUjzae8": {
        "id": "DLUjzae8",
        "title": "More efficient identity-based authenticated key agreement with perfect forward secrecy",
        "abstract": "In 2002, Chen and Kudla proposed a novel identity-based authenticated key agreement protocol using elliptic curve bilinear pairings. Their protocol (referred to as Protocol 2' in their paper) is the most efficient one among such identity-based authenticated key agreement protocols that provides perfect forward secrecy (PFS) with only 1 pairing evaluation for each protocol participant. But, each party needs to transmit 2 elliptic curve points to its partner. In this paper, we propose a new identity-based authenticated key agreement protocol which is not only more computationally efficient but also, most importantly, reduces the total communication overheads to 50%. Furthermore, we show that our new protocol, same as Protocol 2′, achieves perfect forward secrecy as well as all the other desirable security attributes of authenticated key agreement protocols.",
        "keywords": [
            "Authenticated key agreement (AK)",
            "Bilinear pairing",
            "Cryptographic protocol",
            "Identity-based cryptosystem",
            "Perfect forward secrecy (PFS)"
        ],
        "authors": [
            {
                "name": "ShengBao Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Zhenfu Cao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Feng Cao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of Information and Computational Science",
        "year": 2007
    },
    "LGNVmmQE": {
        "id": "LGNVmmQE",
        "title": "Efficient Identity-based Authenticated Key Agreement Protocol with PKG Forward Secrecy",
        "abstract": "For an identity-based authenticated key agreement (ID- AK) protocol, PKG forward secrecy is the strongest notion of forward secrecy, which is about the security of previ- ously established session keys after the master secret key of the Private Key Generatior (PKG) is compromised. In this paper, we put forward a new identity-based authen- ticated key agreement protocol which achieves PKG for- ward secrecy. On its performance, we show that it is more computational efficient than a previously proposed proto- col of Chen and Kudla (called Protocol 20). Furthermore, we examine other security attributes that our new proto- col possesses one bye one.",
        "keywords": [
            "bilinear pairing",
            "identity-based cryptosys- tem",
            "pkg forward secrecy pkg-fs",
            "authenticated key agreement ak",
            "cryptographic protocol",
            "col",
            "key agreement protocol",
            "forward secrecy"
        ],
        "authors": [
            {
                "name": "Shengbao Wang",
                "org": ""
            },
            {
                "name": "Zhenfu Cao",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            }
        ],
        "venue": "I. J. Network Security",
        "year": 2008
    },
    "INLZjp8J": {
        "id": "INLZjp8J",
        "title": "Security model of proxy-multi signature schemes",
        "abstract": "In a proxy multi-signature scheme, a designated proxy signer can generate the signature on behalf of a group of original signers. Although some work has been done in proxy-multi signature schemes, until now there is no formalized definition and security model for them. In this paper, we will give the formal definition and a security model of proxy-multi signature scheme. We also constructed a proxy-multi signature scheme based on the BLS short signature scheme and proved its security in our security model.",
        "keywords": [
            "formalized definition",
            "proxy signer",
            "formal definition",
            "bls short signature scheme",
            "security model",
            "original signer",
            "proxy multi-signature scheme",
            "proxy-multi signature scheme",
            "it security"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China"
            },
            {
                "name": "Zhenfu Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, P.R. China"
            }
        ],
        "venue": "CANS",
        "year": 2006
    },
    "2PWV00uf": {
        "id": "2PWV00uf",
        "title": "An Identity Based Proxy Signature Scheme Secure in the Standard Model",
        "abstract": "Identity-based proxy signature scheme is a special identity-based public key cryptography. In 2005, Gu and Zhu showed how to construct an identity-based proxy signature scheme from any secure identity-based signature scheme, but this construction need PKG to extract the secret proxy signing keys. David Galindo, Javier Herranz and Eike Kiltz proposed another generic construction of identity-based proxy signature scheme in Asiacrypt 2006. This construction method leads to schemes that are somewhat inefficient. This paper present the first direct construction of an identity based proxy signature scheme. Our scheme is based on an identity based signature scheme proposed by Paterson and Schuldt in 2006. The scheme's security is proven in the standard model and rests on the hardness of the computational Diffie-Hellman problem in groups equipped with a pairing.",
        "keywords": [
            "direct construction",
            "identity based proxy signature scheme",
            "standard model",
            "david galindo",
            "security",
            "pkg",
            "secret proxy signing key",
            "signature",
            "signature scheme",
            "proxy signature scheme secure",
            "construction method",
            "biometrics (access control)",
            "proxy signature scheme",
            "identity-based proxy signature scheme",
            "public key cryptography",
            "digital signatures",
            "secure identity-based signature scheme",
            "identity-based public key cryptography",
            "provably secure",
            "generic construction",
            "diffie-hellman problem",
            "identity based",
            "computational modeling",
            "algorithm design and analysis",
            "cryptography",
            "provable security",
            "construction industry"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Zhenfu Cao",
                "org": ""
            }
        ],
        "venue": "GrC",
        "year": 2010
    },
    "64IdHmAg": {
        "id": "64IdHmAg",
        "title": "A secure identity-based multi-proxy signature scheme",
        "abstract": "In a multi-proxy signature scheme, an original signer could authorize a proxy group as his proxy agent. Then only the cooperation of all the signers in the proxy group can generate the proxy signatures on behalf of the original signer. Plenty of multi-proxy signature schemes have been proposed under the certificate-based public key systems. Due to the various applications of the bilinear pairings in cryptography, many identity-based signature schemes have been proposed. In this paper, we give the first formal definition and security model of an identity-based multi-proxy signature scheme, then propose an identity-based multi-proxy signature scheme from bilinear pairings and prove its security in our security model.",
        "keywords": [
            "security model",
            "proxy signature",
            "identity-based signature scheme",
            "certificate-based public key system",
            "provable security",
            "digital signature",
            "bilinear pairings",
            "identity based",
            "proxy agent",
            "proxy group",
            "multi-proxy signature",
            "multi-proxy signature scheme",
            "identity-based multi-proxy signature scheme",
            "original signer",
            "secure identity-based multi-proxy signature",
            "it security",
            "public key"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"
            },
            {
                "name": "Zhenfu Cao",
                "org": "Department of Computer Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China"
            }
        ],
        "venue": "Computers & Electrical Engineering",
        "year": 2009
    },
    "g4ufHeIx": {
        "id": "g4ufHeIx",
        "title": "Biased Bit Commitment and Applications",
        "abstract": "We bring forward the primitive of biased bit commitment, define the security of the model, and present a concrete biased bit commitment scheme based on the braid conjugator search problem. The presented scheme is proved to be information-theoretically hiding and computationally binding in the defined model. Finally, to argue the usefulness of this work, we also sketch out some new applications based on this new primitive.",
        "keywords": [
            "biased bit commitment",
            "braid group",
            "conjugactor search problem",
            "coin tossing",
            "lot-casting"
        ],
        "authors": [
            {
                "name": "Licheng Wang",
                "org": "Shanghai Jiao Tong Univ, Dept Comp Sci & Engn, Shanghai 200030, Peoples R China"
            },
            {
                "name": "Zhenfu Cao",
                "org": "Shanghai Jiao Tong Univ, Dept Comp Sci & Engn, Shanghai 200030, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Shanghai Jiao Tong Univ, Dept Comp Sci & Engn, Shanghai 200030, Peoples R China"
            },
            {
                "name": "Haifeng Qian",
                "org": "Shanghai Jiao Tong Univ, Dept Comp Sci & Engn, Shanghai 200030, Peoples R China"
            },
            {
                "name": "Haiyong Bao",
                "org": "Shanghai Jiao Tong Univ, Dept Comp Sci & Engn, Shanghai 200030, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF INFORMATION SCIENCE AND ENGINEERING",
        "year": 2008
    },
    "zdeJ9yMI": {
        "id": "zdeJ9yMI",
        "title": "Abstract 3125: Noninvasive Imaging of Bone Marrow Stem Cell Homing, Survival, and Proliferation in Ischemic Myocardium",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shuan lin",
                "org": ""
            },
            {
                "name": "ahmad y sheikh",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "sanjiv s gambhir",
                "org": ""
            },
            {
                "name": "robert c robbins",
                "org": ""
            },
            {
                "name": "joseph c wu",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2006
    },
    "wSdexR2W": {
        "id": "wSdexR2W",
        "title": "Effects of long-term culture on human embryonic stem cell aging.",
        "abstract": "In recent years, human embryonic stem (hES) cells have become a promising cell source for regenerative medicine. Although hES cells have the ability for unlimited self-renewal, potential adverse effects of long-term cell culture upon hES cells must be investigated before therapeutic applications of hES cells can be realized. Here we investigated changes in molecular profiles associated with young (<60 passages) and old (>120 passages) cells of the H9 hES cell line as well as young (<85 passages) and old (>120 passages) cells of the PKU1 hES cell line. Our results show that morphology, stem cell markers, and telomerase activity do not differ significantly between young and old passage cells. Cells from both age groups were also shown to differentiate into derivatives of all 3 germ layers upon spontaneous differentiation in vitro. Interestingly, mitochondrial dysfunction was found to occur with prolonged culture. Old passage cells of both the H9 and PKU1 lines were characterized by higher mitochondrial membrane potential, larger mitochondrial morphology, and higher reactive oxygen species content than their younger counterparts. Teratomas derived from higher passage cells were also found to have an uneven preference for differentiation compared with tumors derived from younger cells. These findings suggest that prolonged culture of hES cells may negatively impact mitochondrial function and possibly affect long-term pluripotency.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Asimina Hiona",
                "org": ""
            },
            {
                "name": "Andrew Stephen Lee",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Mei Huang",
                "org": ""
            },
            {
                "name": "Zongjin Li",
                "org": ""
            },
            {
                "name": "Athena Cherry",
                "org": ""
            },
            {
                "name": "Xuetao Pei",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "Stem cells and development",
        "year": 2011
    },
    "joadbpAl": {
        "id": "joadbpAl",
        "title": "e0469 Multimodality imaging evaluation of functional and clinical benefits of percutaneous coronary intervension on patients with chronic total occlusion lesion",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dongdong sun",
                "org": ""
            },
            {
                "name": "jing wang",
                "org": ""
            },
            {
                "name": "yue tian",
                "org": ""
            },
            {
                "name": "kazim h narsinh",
                "org": ""
            },
            {
                "name": "haichang wang",
                "org": ""
            },
            {
                "name": "chengxiang li",
                "org": ""
            },
            {
                "name": "xiaowei ma",
                "org": ""
            },
            {
                "name": "yabing wang",
                "org": ""
            },
            {
                "name": "dongjuan wang",
                "org": ""
            },
            {
                "name": "joseph c wu",
                "org": ""
            },
            {
                "name": "jie tian",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            }
        ],
        "venue": "Heart",
        "year": 2012
    },
    "Wj2FIvz0": {
        "id": "Wj2FIvz0",
        "title": "Influences of Percusurge distal protection device on the level of plasma P-selection,tissue type plasminogen activator,plasminogen activator inhibitor-1 in coronary intervention in acute myocardial infarction",
        "abstract": "AIM To investigate influences of Percusurge distal protection device(DPD) on the level of P-selection,tissue-type plasminogen activator and plasminogen activator inhibitor-1 during coronary intervention with acute myocardial infarction.METHODS 72 acute ST-elevation myocardial infarctiion patients received primary coronary intervention were included into this study.Patients were divided into two groups,test group:percusurge DPD were attempted during emergency PCI(n=39);control group:percusurge DPD were not attempted(n=33).Placing a right coronary artery catheter into the coronary sinus,blood samples were drawed to measure plasma P-selection(Ps),tissue type plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1).RESULTS ①The test group Ps level after 6 hours PCI was significantly lower than that of control group(P<0.05).The t-PA level decreased and PAI-1 level increased significantly during the frist 6 hours after the PCI,but both of them were not significant different with control group(P<0.05);②The incidence rate of major adverse cardiac events(MACE) was no significant difference between two groups during hospitalization.CONCLUSION DPD can protect the distal vessels,reduce the activity of the platelet,and the no-flow phenomenon in the thrombus laden arteries reperfusion in acute myocardial infarction.",
        "keywords": [
            "plasminogen activator inhibitor-1",
            "percutaneous coronary intervention",
            "P-selection",
            "myocardial infarction",
            "Percusurge guardwire distal protection system",
            "tissue-type plasminogen activator"
        ],
        "authors": [
            {
                "name": "GUO Xuan",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            },
            {
                "name": "LI Cheng-xiang",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            },
            {
                "name": "WANG Hai-chang",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            },
            {
                "name": "JIA Guo-liang",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            },
            {
                "name": "FENG Xu-yang",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            },
            {
                "name": "GAO Yan",
                "org": "Department of Cardiology,Xijing Hospital,Fouth Military Medical University,Xi′an,Shaanxi "
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2006
    },
    "fxxmgsuG": {
        "id": "fxxmgsuG",
        "title": "Roles of miRNA in cardiovascular development and dysfunction.",
        "abstract": "Non-coding RNAs, especially microRNAs (miRNAs), have been recently found to play a major role in the post-transcriptional regulation of both development and dysfunction of the cardiovascular system. Mechanistically, the induction or repression of miRNAs occurring in cardiovascular dysfunction triggers downstream cardiac events in a cell-type-specific manner. More importantly, the endogenous microRNAs' disturbance can be modified to rescue cardiac function through exogenous overexpressing or neutralizing strategy. In this paper, we summarizes the current knowledge about miRNAs functions as well as their role in cardiac development and disease, and reports novel miRNAs-based therapeutic approaches to counteract maladaptive remodeling upon cardiac dysfunction.",
        "keywords": [
            "Cardiovascular",
            "development",
            "dysfunction",
            "miRNA"
        ],
        "authors": [
            {
                "name": "W Huang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China"
            },
            {
                "name": "Q Yu",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China"
            },
            {
                "name": "Q Wang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China"
            },
            {
                "name": "F Cao",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China"
            }
        ],
        "venue": "CURRENT MEDICINAL CHEMISTRY",
        "year": 2013
    },
    "Rdr3K5I0": {
        "id": "Rdr3K5I0",
        "title": "Advances in the Study of Molecular Imaging for microRNA Regulation",
        "abstract": "MicroRNAs(miRNAs) are RNA molecules of approximately 22 nucleotides(nt) that recognize target mRNAs by perfect or imperfect complementary base-pairing and thereby result in mRNA degradation or translation repression.A large number of studies have revealed essential roles for miRNAs in a wide variety of biological processes such as cellular proliferation,differentiation,apoptosis and tumorigenesis.Currently,methods like northern blot,real-time PCR or microarray,have been widely used to quantify miRNA expression.However,these techniques are often time-consuming,laborious and of requiring repetitive sampling and invasive procedures.Recently,the remarkable development of molecular imaging techniques have enabled repeated noninvasive quantitative imaging of miRNAs in living cells.Herein,we reviewed the molecular imaging strategies that have been developed to visualize miRNA expression in living subjects based on different reporter gene systems.",
        "keywords": [
            "MicroRNAs",
            "Molecular imaging",
            "Reporter gene system"
        ],
        "authors": [
            {
                "name": "WANG Fu",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China;Life Sciences Research Center,School of Life Sciences and Technology,Xidian University,Xi'an ,China"
            },
            {
                "name": "TIAN Jie",
                "org": "Life Sciences Research Center,School of Life Sciences and Technology,Xidian University,Xi'an ,China;Institute of Automation,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            }
        ],
        "venue": "Acta Biophysica Sinica",
        "year": 2011
    },
    "rDgmUq30": {
        "id": "rDgmUq30",
        "title": "Protective effects and mechanism of simvastatin on hypoxia/reoxygenation-induced apoptosis in rat cardiomyocyte",
        "abstract": "AIM: To explore the protective effects and mechanism of simvastatin on hypoxia/reoxygenation-induced cardiac injury.METHODS: Cultured cardiomyocytes from neonatal rats subjected to hypoxia for 2 h and reoxygenation for 4 h were divided randomly into four groups: control group,hypoxia 2h/reoxygenation 4 h group(H/R 4 h),simvastatin(SIM) pretreated group(concentration: 0.1 μmol/L,1 μmol/L,10 μmol/L),and neutralizing antibody group of TLR4: MTS510(10 μg/L).Cardiomyocyte apoptosis was detected by flow cytometry,concentration of LDH was measured by ELISA and expression of TLR4 protein was measured by Western blot.RESULTS: Compared with that in control and H/R 4 h groups,H/R-induced apoptosis was markedly attenuated in SIM group in a dose-dependent manner.Protective effects of simvastatin began at 0.1 μmol/L and the maximal effects reached at 10 μmol/L.After the addition of neutralizing antibody of TLR4,cardiocyte apoptosis and activities of LDH decreased.CONCLUSION: Simvastatin protects hypoxia/reoxygenation-induced cardiac injury in a dose-dependent manner,and the protective effects are in association with TLR4 signalling pathway.",
        "keywords": [
            "apoptosis",
            "simvastatin",
            "cardiac myocytes",
            "TLR4",
            "hypoxia/reoxygenation"
        ],
        "authors": [
            {
                "name": "ZHANG Shen-wei",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "GAO Hao-kao",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CHEN Jiang-hong",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "LI Cong-ye",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "PAN Yun-hu",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "Guo Wen-yi",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2011
    },
    "UgJPBxOf": {
        "id": "UgJPBxOf",
        "title": "Efficacy study of recombinant human brain natriuretic peptide in patients with acute decompensated heart failure and different severities of H_2O/Na~+ retention",
        "abstract": "AIM: To compare the effect of intravenous infusion of recombinant human brain natriuretic peptide(rhBNP) on the hemodynamic profile and its clinical efficacy in patients with acute decompensated heart failure(ADHF).METHODS: Forty ADHF patients enrolled in our hospital were randomized equally to catheter group where hemodynamic changes were monitored with Swan-Ganz and noncatheter group(n=20 in each group).Pulmonary capillary wedge pressure(PCWP),pulmonary artery pressure(PAP) and right atrial pressure(RAP) were recorded and cardiac output(CO) and cardiac index(CI) were assessed by heat-sensitive dilution method before drug administration and 0.5,1,3,6 and 24 h after drug administration.Patients were divided into experiment group and control group and all patients received rhBNP with an initial i.v.bolus of 2 μg/kg followed by continuous i.v.titration of 0.01 μg/(kg·min) for 24 h.Dyspnea,overall symptom improvement in clinical conditions and fluid input and output were recorded before and 0.5,1,3,6 and 24 h after drug administration.RESULTS: The alleviation of dyspnea and overall symptoms were more significant in experimental group compared to those in control group,accompanied by enhanced natriuretic effect [(2.7±0.8) L vs.(1.7±0.4) L,P=0.01].Patients in the experiment group experienced more rapid,apparent,stable and long-lasting declines in PCWP and RAP,with significant difference between groups.No significant intergroup difference was found in PAP between groups and no inter-and intra-group significant differences were observed in CI.CONCLUSION: Compared with ADHF patients with less severe H2O/Na+ retention,ADHF patients with more serious H2O/Na+ retention have more favorable acute hemodynamic profile and better clinical response to rhBNP treatment.ADHF patients with severe H2O/Na+ retention may be the optimal target population for clinical application of rhBNP treatment.",
        "keywords": [
            "decompensated heart failure",
            "brain natriuretic peptide",
            "hemodynamics"
        ],
        "authors": [
            {
                "name": "TAO Bo",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHAO Zhi-jing",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "LI Wei-jie",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Hai-chang",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2010
    },
    "CM1jdreS": {
        "id": "CM1jdreS",
        "title": "Molecular Imaging for Monitoring Survival and Proliferation of Adipose Derived Mesenchymal Stem Cells in vitro and in vivo after Pretreatment with VEGF",
        "abstract": "Although stem cell therapy holds promise for the regenerative treatment of ischemic heart disease,the tragic fate of engrafted stem cells is still a hurdle for the therapeutic effect.Previous studies showed that molecular imaging could be a realtime and quantitative effective approach to visualize and monitor stem cells,while vasoactive factors such as vascular endothelial growth factor(VEGF) may have protective effect on the stem cell.In this study,adipose tissue derived mesenchymal stem cells(ADMSCs),which stably expressed firefly luciferase gene,were cultured at the first step.Then bioluminescence imaging and other methods were used to visualize and quantify the ADMSCs' survival and proliferation,and confirmed whether VEGF pretreatment could affect the cells' viability.The results from bioluminescence imaging and quantitative analysis implied that VEGF pretreatment significantly enhanced the survival and proliferation of ADMSCs after hypoxia/reoxygenation injury in vitro,and prolonged ADMSCs' lifetime in vivo.Eventually,it concluded that reporter gene molecular imaging could be a direct,efficient and noninvasive strategy for monitoring the MSCs' biological process in vitro and in vivo,while it could well evaluate the effect of protective factors,such as VEGF,on MSCs with high efficacy.",
        "keywords": [
            "Mesenchymal stem cells",
            "VEGF",
            "Molecular imaging"
        ],
        "authors": [
            {
                "name": "FAN Weiwei",
                "org": ""
            },
            {
                "name": "WANG Yabin",
                "org": ""
            },
            {
                "name": "ZHANG Rongqing",
                "org": ""
            },
            {
                "name": "LI Congye",
                "org": ""
            },
            {
                "name": "LI Shuang",
                "org": ""
            },
            {
                "name": "CAO Feng",
                "org": ""
            }
        ],
        "venue": "Acta Biophysica Sinica",
        "year": 2011
    },
    "gzvOzyrB": {
        "id": "gzvOzyrB",
        "title": "Impact of the residual SYNTAX score on clinical outcomes after percutaneous coronary intervention for patients with chronic renal insufficiency.",
        "abstract": "Objectives This study demonstrated the prognostic value of the residual SYNTAX score (rSS) for patients with chronic renal insufficiency (CRI). Background The rSS has been proposed as a useful tool for quantifying and stratifying the degree and complexity of residual stenosis and predicting long-term clinical outcomes following percutaneous coronary intervention (PCI). However, it has never been validated for patients with CRI. Methods A total of 2,468 consecutive patients with an estimated glomerular filtration rate 0 were defined as having incomplete revascularization and were stratified into the reasonable incomplete revascularization (RICR; 0 < rSS <= 8) group or the incomplete revascularization (ICR; rSS >8) group. Their outcomes were compared to those of the complete revascularization (CR) group. Results During follow-up (median, 3 years; range, 1.5-5 years), the ICR group had the highest incidence of all-cause death, cardiac death, myocardial infarction (MI), unplanned revascularization, stroke, and major adverse cardiovascular and cerebrovascular events (MACCE). Despite having higher rates of unplanned revascularization and MACCE, RICR group had comparable all-cause mortality, cardiac mortality, MI, and stroke with CR group. A multivariable Cox analysis indicated that rSS was an independent predictor of cardiac death, MI, unplanned revascularization, stroke, and MACCE. Furthermore, compared with baseline SYNTAX score, rSS had stronger prognostic accuracy when predicting the risk of unplanned revascularization, stroke, and MACCE at the 3-year follow-up. Conclusions The rSS is a powerful indicator of clinical outcomes and may help determine reasonable levels of revascularization for patients with CRI following PCI.",
        "keywords": [
            "cardiac death",
            "coronary artery disease",
            "myocardial infarction",
            "revascularization"
        ],
        "authors": [
            {
                "name": "Liqiu Yan",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Peiyao Li",
                "org": "Tsinghua Univ, Dept Comp Sci, Beijing, Peoples R China"
            },
            {
                "name": "Yabin Wang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Dong Han",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian, Shaanxi, Peoples R China"
            },
            {
                "name": "Sulei Li",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Jibin Zhang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Min Jiang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Li Fan",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "Yaling Han",
                "org": "Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Liaoning, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            }
        ],
        "venue": "CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS",
        "year": 2020
    },
    "Rcghwz2l": {
        "id": "Rcghwz2l",
        "title": "Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe.",
        "abstract": "Pro-inflammatory M1 macrophage is identified as a prominent component initializing the progress of vulnerable atherosclerotic plaque. Here, we constructed anti-MARCO NaGdF4:Yb,Er@NaGdF4 upconversion nanoparticles (UCNPs) by conjugating polyclonal MARCO antibody to the surface of NaGdF4:Yb,Er@NaGdF4 via condensation reaction. UCNPs displayed highly mono-dispersion with average sizes of 26.7 ± 0.8 nm and favorable biocompatibility. In vivo upconversion optical imaging revealed that distinctive fluorescence signal could be observed in the regions of carotid artery 10 min post-injection, reached peak value at 1 h and decreased back to baseline at 24 h post-injection. The carotid artery wall demonstrated high signal intensity on T1-weighted MR images after anti-MARCO UCNPs injection, as determined by 7.0T MRI. Immunofluorescence staining of tissue section of carotid artery revealed that MARCO was highly abundant in shoulder regions of plaque. Anti-MARCO UCNPs is a promising optical/MRI dual-modality imaging probe which can non-invasively reflect M1 phenotype macrophages behavior in vivo.",
        "keywords": [
            "Vulnerable atherosclerotic plaque",
            "M1 macrophage polarization",
            "Multimodality molecular imaging",
            "Upconversion nanoprobe"
        ],
        "authors": [
            {
                "name": "Yabin Wang",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Yan Zhang",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Zhao Wang",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Jibin Zhang",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Rui Rui Qiao",
                "org": "Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing, 100190, China"
            },
            {
                "name": "Mengqi Xu",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Ning Yang",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Lei Gao",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            },
            {
                "name": "Hongyu Qiao",
                "org": "Department of Pediatric, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China"
            },
            {
                "name": "Mingyuan Gao",
                "org": "Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing, 100190, China"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, 2nd Medical Center of Chinese PLA General Hospital, Beijing, 100853, China"
            }
        ],
        "venue": "Biomaterials",
        "year": 2019
    },
    "7Vjw613O": {
        "id": "7Vjw613O",
        "title": "Molecular imaging and transcriptional profiling of bone marrow cell therapy for ischemic heart disease",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ahmad y sheikh",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "joshua m spin",
                "org": ""
            },
            {
                "name": "diego ardigo",
                "org": ""
            },
            {
                "name": "daniel l kraft",
                "org": ""
            },
            {
                "name": "giovanni farjardo",
                "org": ""
            },
            {
                "name": "daniel bernstein",
                "org": ""
            },
            {
                "name": "sanjiv s gambhir",
                "org": ""
            },
            {
                "name": "irving l weissman",
                "org": ""
            },
            {
                "name": "r c robbins",
                "org": ""
            },
            {
                "name": "joseph wu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "oSHtRVVI": {
        "id": "oSHtRVVI",
        "title": "NDRG2: a newly identified mediator of insulin cardioprotection against myocardial ischemia-reperfusion injury.",
        "abstract": "The N-myc downstream-regulated gene 2 (NDRG2) is involved in cell apoptosis and survival. Although reported to be highly expressed in the cardiac tissue, the biological function of NDRG2 in the heart remains to be established. Insulin exerts protective effects against myocardial ischemia/reperfusion (I/R) injury through the PI3K/Akt pathway. Here, we examined the changes in phosphorylation of NDRG2, a novel substrate and phosphoprotein of Akt, in insulin-induced protection against myocardial I/R. Rat hearts were subjected to 30 min regional ischemia followed by reperfusion with or without insulin at the onset of reperfusion. Reperfusion with insulin inhibited myocardial apoptosis and reduced infarct size, as well as significantly up-regulated myocardial Akt and NDRG2 phosphorylation levels compared with the I/R group. These effects of insulin were blocked by pretreatment with the PI3K inhibitor wortmannin or Akt inhibitor. To further ascertain the role of NDRG2 in insulin-induced cardioprotection, cardiomyocytes were transduced with a lentivirus encoding shRNA targeting NDRG2 (loss-of-function), which rendered the cells more susceptible to I/R injury and significantly blunted the anti-apoptotic effect of insulin. Moreover, the NDRG2 shRNA lentivirus was tested in vivo, and NDRG2 knockdown aggravated myocardial I/R injury and attenuated the insulin-mediated cardioprotection against I/R injury. Taken together, these results suggest a novel role of PI3K/Akt/NDRG2 signaling in the cardioprotective effect of insulin.",
        "keywords": [
            "ndrg2",
            "heart",
            "akt",
            "ischemia/reperfusion injury",
            "insulin"
        ],
        "authors": [
            {
                "name": "Zhongchan Sun",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Guang Tong",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Nan Ma",
                "org": "Tangdu Hospital, Fourth Military Medical University(Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Jianying Li",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Xiujuan Li",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Shuang Li",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Jingyu Zhou",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Lize Xiong",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Feng Cao",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Libo Yao",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Haichang Wang",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Lan Shen",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            }
        ],
        "venue": "Basic research in cardiology",
        "year": 2013
    },
    "LSyDdMi1": {
        "id": "LSyDdMi1",
        "title": "Transcriptional and functional profilling of human embryonic stem cell-derived cardiomyocytes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ronald a li",
                "org": ""
            },
            {
                "name": "andrew lee",
                "org": ""
            },
            {
                "name": "j d fu",
                "org": ""
            },
            {
                "name": "irving l weissman",
                "org": ""
            },
            {
                "name": "kitchener d wilson",
                "org": ""
            },
            {
                "name": "robert c robbins",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "roger a wagner",
                "org": ""
            },
            {
                "name": "micha drukker",
                "org": ""
            },
            {
                "name": "xudong xie",
                "org": ""
            },
            {
                "name": "sanjiv s gambhir",
                "org": ""
            },
            {
                "name": "joseph c wu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "vNK4pw6j": {
        "id": "vNK4pw6j",
        "title": "Molecular Imaging of Apelin on Proliferation and Function of Adipose Tissue Derived Mesenchymal Stem Cells",
        "abstract": "Apelin,a novel peptide with significant cardioactive properties,has various beneficial effects on vascular protection.This study was designed to evaluate the contribution of apelin to the therapeutic efficacy of mesenchymal stem cells under ischemia.Adipose derived mesenchymal stem cells(AD-MSCs) stablely expressing firefly luciferase(Fluc) were isolated from β-actin-luc transgenic mice and characterized by flow cytometry and bioluminescence imaging(BLI).AD-MSCs were subjected to normal control,hypoxia 6 h + reoxygen 2 h(H/R) and H/R+apelin(10-10~10-5 mol/L).Cell survival and proliferation were assessed by BLI and MTT assay.The expressions of Akt and pAkt after apelin administration were analyzed by Western blot.It was found that AD-MSCs were positive for the CD44 and CD90 by flow cytometry.The firefly luciferase expression was well correlated with cell numbers which proved by both BLI and luciferase assay.Administration of apelin increased proliferation of AD-MSCs under hypoxia compared with control groups.Western blot assay revealed the phosphorylation of Akt was higher in apelin group than that in control groups.The results suggested that apelin has beneficial effects on the proliferation and survival of mesenchymal stem cells under hypoxia and might constitute an important therapy target in stem cell therapy for ischemic disease.",
        "keywords": [
            "Mesenchymal stem cells",
            "Apelin",
            "Hypoxia",
            "pAkt",
            "Molecular imaging"
        ],
        "authors": [
            {
                "name": "LIANG Dong",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "LI Shuang",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "ZHANG Rongqing",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "LI Congye",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "ZHU Shunming",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "GAO Lina",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "WANG Haichang",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            },
            {
                "name": "CAO Feng",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an ,China"
            }
        ],
        "venue": "Acta Biophysica Sinica",
        "year": 2011
    },
    "6dLgAru2": {
        "id": "6dLgAru2",
        "title": "GW25-e4495 ZP2495 improves cardiomyocyte energy metabolism post myocardial ischemia-reperfusion injury in db/db diabetic mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "li shuang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shanxi, Peoples R China"
            },
            {
                "name": "dongdong sun",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shanxi, Peoples R China"
            },
            {
                "name": "feng cao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY",
        "year": 2014
    },
    "nUOAWFIC": {
        "id": "nUOAWFIC",
        "title": "Electroacupuncture pre-treatment ameliorates myocardial ischaemia/reperfusion injury through regulation of cannabinoid receptor type 2",
        "abstract": "Electroacupuncture (EA) therapy has widely been accepted as a useful therapeutic technique with low risk in the clinical setting for prevention from cardiac disease. However, the physiological mechanism under which this protective effect works remains unclear. The present study investigated the effects of EA pretreatment on myocardial ischaemia/reperfusion (MI/R) injury in mice and its possible signalling pathway. Mice were randomly divided into Sham, MI/R, EA + MI/R, EA(-) + MI/R, and AM630 + EA + MI/R groups. We reported that EA pretreatment significantly ameliorated MI/R injury, evidenced by increased cardiac function, reduced infarct size, and decreased apoptosis. This was associated with a reduction of oxidative stress in the infarcted myocardium, which was through CB2. The CB2 expression was up-regulated in the heart after EA pretreatment, as well as heart tissue content of N-arach-idonoylethanolamine-anandamide and 2-arachidonylglycerol. Furthermore, the expression of adenosine monophosphate-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) in the left ventricular myocardial tissue was decreased in the MI/R group, whereas increased in the EA pretreatment group. Administration of AM630 before EA pretreatment did not improve cardiac function and inhibit oxidative stress. Preinjection of AM630 or AMPK inhibitor compound C could partially decrease the expression of EA pretreatment-mediated AMPK or PGC-1 alpha. Pretreatment with EA increased the production of endocannabinoid, which elicited protective effects against MI/R injury through CB2 activation. The mechanism of this effect was related to the activation of AMPK/PGC-1 alpha pathway, followed by an inhibition of oxidative stress.",
        "keywords": [
            "Electroacupuncture",
            "Cannabinoid receptor type 2",
            "Myocardial ischemia/reperfusion",
            "Oxidative stress"
        ],
        "authors": [
            {
                "name": "dongjuan wang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "ran zhang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "xuan zhou",
                "org": "Gen Hosp Guang Zhou Mil Command, Dept Cardiol, Guangzhou 510011, Guangdong, Peoples R China"
            },
            {
                "name": "sai ma",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "xing qin",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "jinda wang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "haokao gao",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "qiang wang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "congye li",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "yundai chen",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China"
            },
            {
                "name": "lize xiong",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Anesthesiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "feng cao",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            }
        ],
        "venue": "EUROPEAN HEART JOURNAL SUPPLEMENTS",
        "year": 2015
    },
    "SyvigdzW": {
        "id": "SyvigdzW",
        "title": "A PKC-β inhibitor protects against cardiac microvascular ischemia reperfusion injury in diabetic rats",
        "abstract": "PKC-beta inhibitor Ruboxistaurin (RBX or LY333531) can be used to reverse diabetic microvascular complication. However, it has not been previously established whether RBX can protect against ischemia/reperfusion (I/R) injury of cardiac microvessels in diabetic rats. STZ-induced diabetic rats were randomized into four groups and underwent I/R procedures. Cardiac barrier function and the region of cardiac microvascular lesion were examined. Cell monolayer barrier function was detected in cultured cardiac microvascular endothelial cells (CMECs) subjected to simulated I/R (SI/R). PKC-beta siRNA was transfected into CMECs to silence PKC-beta. Apoptosis Index of CMECs was detected by TUNEL assay and phosphor-LIMK2 protein expression was examined by Western blot analysis. RBX and insulin administration significantly reduced the cardiac microvascular lesion region and Apoptosis Index of endothelial cells (all P < 0.05 vs. no-treatment group). RBX decreased phosphor-LIMK2 expression (P < 0.05 vs. no-treatment group). RBX pretreatment and transfection with PKC-beta siRNA induced a rapid barrier enhancement in CMECs monolayer as detected by increased transendothelial electrical resistance (TER) and decreased FITC-dextran clearance (all P < 0.05 vs. no-treatment group). Meanwhile, RBX pretreatment and transfection with PKC-beta siRNA significantly decreased TUNEL positive CMECs and phosphor-LIMK2 expression in cultured CMECs (all P < 0.05 vs. no-treatment group). RBX pretreatment reduced F-actin/G-actin in cultured CMECs, reproducing the same effect as PKC-beta siRNA. These data indicate that PKC-beta inhibitor (RBX) may be helpful in attenuating the risk of severe cardiac microvascular I/R injury in diabetic rats partly due to its maintenance of endothelial barrier function and anti-apoptotic effect.",
        "keywords": [
            "Hyperglycemia",
            "PKC-β",
            "Cardiac microvascular endothelial cells",
            "Ischemia/reperfusion",
            "Apoptosis",
            "Permeability"
        ],
        "authors": [
            {
                "name": "Liping Wei",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Dongdong Sun",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Zhiyong Yin",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Yuan Yuan",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Andrew Hwang",
                "org": "Stanford University Department of Radiology, Molecular Imaging Program of Stanford Stanford CA USA"
            },
            {
                "name": "Yingmei Zhang",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Rui Si",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Rongqing Zhang",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Wenyi Guo",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Feng Cao",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            },
            {
                "name": "Haichang Wang",
                "org": "Fourth Military Medical University Department of Cardiology, Xijing Hospital 710032 Xi’an Shaanxi China"
            }
        ],
        "venue": "Apoptosis : an international journal on programmed cell death",
        "year": 2010
    },
    "c9a1ykrN": {
        "id": "c9a1ykrN",
        "title": "MTORC1 AND MTORC2 PLAY DIFFERENT ROLES IN THE FUNCTIONAL SURVIVAL OF TRANSPLANTED ADIPOSE-DERIVED STROMAL CELLS IN HINDLIMB ISCHAEMIA MICE VIA REGULATING INFLAMMATION IN VIVO",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "x qin",
                "org": ""
            },
            {
                "name": "kuoliang cheng",
                "org": ""
            },
            {
                "name": "wei fan",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "k wu",
                "org": ""
            },
            {
                "name": "liansong xiong",
                "org": ""
            },
            {
                "name": "chunyan li",
                "org": ""
            },
            {
                "name": "shiying hu",
                "org": ""
            },
            {
                "name": "shaoyu wang",
                "org": ""
            },
            {
                "name": "kazim h narsinh",
                "org": ""
            }
        ],
        "venue": "Heart",
        "year": 2012
    },
    "k4as6gNH": {
        "id": "k4as6gNH",
        "title": "AS-5: Long-Term Myocardial Functional Improvement after Autologous Bone Marrow Mononuclear Cell Transplantation in Patients with ST-Segment Elevation Myocardial Infarction (STEMI): 4-Years Follow-Up",
        "abstract": "",
        "keywords": [
            "myocardial infarct",
            "mononuclear cell"
        ],
        "authors": [
            {
                "name": "xue li",
                "org": ""
            },
            {
                "name": "haichang wang",
                "org": ""
            },
            {
                "name": "dong dong sun",
                "org": ""
            },
            {
                "name": "cheng xiang li",
                "org": "university of california"
            },
            {
                "name": "kazim h narsinh",
                "org": ""
            },
            {
                "name": "xu yang fen",
                "org": ""
            },
            {
                "name": "wenyi guo",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            }
        ],
        "venue": "American Journal of Cardiology",
        "year": 2009
    },
    "X3Kbjh1X": {
        "id": "X3Kbjh1X",
        "title": "In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.",
        "abstract": "Recent studies have shown that stem cell therapy can promote tissue regeneration; however, monitoring stem cells in vivo remains problematic owing to limitations of conventional histological assays and imaging modalities.Murine embryonic stem (ES) cells were stably transduced with a lentiviral vector carrying a novel triple-fusion (TF) reporter gene that consists of firefly luciferase, monomeric red fluorescence protein, and truncated thymidine kinase (fluc-mrfp-ttk). ES cell viability, proliferation, and differentiation ability were not adversely affected by either reporter genes or reporter probes compared with nontransduced control cells (P=NS). Afterward, 1x10(7) of ES cells carrying the TF reporter gene (ES-TF) were injected into the myocardium of adult nude rats (n=20). Control animals received nontransduced ES cells (n=6). At day 4, the bioluminescence and positron emission tomography signals in study animals were 3.7x10(7)+/-5.8x10(6) photons.s(-1).cm(-2) per steradian (sr) and 0.08+/-0.03% injected dose/g, respectively (P<0.05 versus control). Both signals increased progressively from week 1 to week 4, which indicated ES cell survival and proliferation in the host. Histological analysis demonstrated the formation of intracardiac and extracardiac teratomas. Finally, animals (n=4) that were treated with intraperitoneal injection of ganciclovir (50 mg/kg) did not develop teratomas when compared with control animals (n=4) treated with saline (1 mL/kg).This is the first study to characterize ES cells that stably express fluorescence, bioluminescence, and positron emission tomography reporter genes and monitor the kinetics of ES cell survival, proliferation, and migration. This versatile imaging platform should have broad applications for basic research and clinical studies on stem cell therapy.",
        "keywords": [
            "heart diseases stem cells positron emission tomography nuclear medicine molecular imaging",
            "nuclear medicine",
            "molecular imaging",
            "stem cell",
            "embryonic stem cell"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Shuan Lin",
                "org": ""
            },
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Pritha Ray",
                "org": ""
            },
            {
                "name": "Manishkumar Patel",
                "org": ""
            },
            {
                "name": "Xianzhong Zhang",
                "org": ""
            },
            {
                "name": "Micha Drukker",
                "org": ""
            },
            {
                "name": "Scott J Dylla",
                "org": ""
            },
            {
                "name": "Andrew J Connolly",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            },
            {
                "name": "Irving L Weissman",
                "org": ""
            },
            {
                "name": "Sanjiv S Gambhir",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2006
    },
    "5q4jnxD4": {
        "id": "5q4jnxD4",
        "title": "Protective effects of ghrelin on rat coronary microvascular endothelial cells",
        "abstract": "AIM: To investigate the effects of ghrelin on the proliferation,migration and nitric oxide(NO) secretion in rat cardiac microvascular endothelial cells(CMECs).METHODS: CMECs were isolated from rat left ventricles by enzyme digestion and cultured in fibronectin-coated dishes.The obtained CMECs were identified by Dil-ac-LDL phagocytosis and collected cells were divided into control group,groups with different doses of ghrelin(1×10-9 mol/L,1×10-8 mol/L,1×10-7 mol/L) and ghrelin + antagon LY294002 group(1×10-7 mol/L ghrelin+20 mol/L LY294002).After 24 h exposure,proliferation capability was measured by MTT assay,migration of CMECs was detected by transwell assay and NO secretion of CMECs was measured by nitrate reduction.RESULTS: CMECs were successfully obtained by enzyme digestion and ghrelin at 10-8-10-7 mol/L promoted proliferation,migration and NO secretion of CMECs(P<0.05).However,LY294002 inhibited the ghrelin-promoting proliferation and migration of CMECs and decreased ghrelin-stimulating NO secretion of CMECs.CONCLUSION: Ghrelin can promote proliferation,migration and NO secretion of rat coronary microvascular endothelial cells at some dose.This may be related to the activation of AKT/PI3K signal pathway.",
        "keywords": [
            "cell proliferation",
            "ghrelin",
            "nitric oxide",
            "cardiac microvascular endothelial cell"
        ],
        "authors": [
            {
                "name": "WANG Ya-bin",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "SUN Dong-dong",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHAO Li",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Rong-qing",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Hai-Chang",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2010
    },
    "dAisszBg": {
        "id": "dAisszBg",
        "title": "In vivo visualization of apelin in survival and function of adipose-derived mesenchymal stem cells in hind limb of ischemic mice",
        "abstract": "AIM:To evaluate the contribution of apelin,a novel peptide with significant cardioactive properties and the therapeutic efficacy of mesenchymal stem cells in hind limb ischemia mice.METHODS: Adipose-derived mesenchymal stem cells(AD-MSCs) expressing firefly luciferase(Fluc) were isolated from β-actin-luc mice and characterized by flow cytometry and bioluminescence imaging(BLI).Male FVB mice underwent femoral artery ligation and received AD-MSCs(1×106) or AD-MSCs with apelin intraquadriceps femoris muscle injection.Cell survival was imaged by BLI and expressions of Akt and pAkt after cellular therapy were analyzed by Western blot.RESULTS: In vivo BLI revealed acute donor cell death of AD-MSCs within 1 week after transplantation.In contrast,signals of injected cells were still present after 1 week in AD-MSCs in apelin group(P<0.05).In vitro apelin treatment of AD-MSCs exposed to hypoxia increased cell proliferation and considerable increases in phosphorylation of Akt were found in AD-MSCs pretreated with apelin.CONCLUSION: Apelin has beneficial effects on the therapeutic efficacy and survival maintenance of AD-MSCs in hind limb ischemia and may constitute an important target therapy in ischemic disease.",
        "keywords": [
            "mesenchymal stem cells",
            "molecular imaging",
            "apelin",
            "ischemia"
        ],
        "authors": [
            {
                "name": "LIANG Dong",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "DUAN Hong-li",
                "org": "Department of Cardiology,People' s Hospital,Lintong District,Xi' an ,Shaanxi,China"
            },
            {
                "name": "QIN Xing",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "CHENG Kang",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "MA Ke",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "LIU Tong",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2012
    },
    "v12qEito": {
        "id": "v12qEito",
        "title": "Protective effects of low-frequency magnetic fields on cardiomyocytes from ischemia reperfusion injury via ROS and NO/ONOO-.",
        "abstract": "Background. Cardiac ischemia reperfusion (I/R) injury is associated with overproduction of reactive oxygen species (ROS). Low frequency pulse magnetic fields (LFMFs) have been reported to decrease ROS generation in endothelial cells. Whether LFMFs could assert protective effects on myocardial from I/R injury via ROS regulation remains unclear. Methods. To simulate in vivo cardiac I/R injury, neonatal rat cardiomyocytes were subjected to hypoxia reoxygenation (H/R) with or without exposure to LFMFs. Cell viability, apoptosis index, ROS generation (including O-2(-) and ONOO-), and NO production were measured in control, H/R, and H/R + LFMF groups, respectively. Results. H/R injury resulted in cardiomyocytes apoptosis and decreased cell viability, whereas exposure to LFMFs before or after H/R injury significantly inhibited apoptosis and improved cell viability (P < 0.05). LFMFs treatment could suppress ROS (including O-2(-) and ONOO-) generation induced by H/R injury, combined with decreased NADPH oxidase activity. In addition, LFMFs elevated NO production and enhanced NO/ONOO- balance in cardiomyocytes, and this protective effect was via the phosphorylation of endothelial nitric oxide synthase (eNOS). Conclusion. LFMFs could protect myocardium against I/R injury via regulating ROS generation and NO/ONOO- balance. LFMFs treatment might serve as a promising strategy for cardiac I/R injury.",
        "keywords": [
            "magnetic fields",
            "oxygen",
            "apoptosis",
            "nitric oxide",
            "phosphorylation",
            "reactive oxygen species"
        ],
        "authors": [
            {
                "name": "Sai Ma",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Zhengxun Zhang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Fu Yi",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Yabin Wang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Xiaotian Zhang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Xiujuan Li",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Yuan Yuan",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shannxi, Peoples R China"
            }
        ],
        "venue": "OXIDATIVE MEDICINE AND CELLULAR LONGEVITY",
        "year": 2013
    },
    "alznvJcS": {
        "id": "alznvJcS",
        "title": "Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.",
        "abstract": "Human embryonic stem cells (hESCs) can serve as a potentially limitless source of cells that may enable regeneration of diseased tissue and organs. Here we investigate the use of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in promoting recovery from cardiac ischemia reperfusion injury in a mouse model. Using microarrays, we have described the hESC-CM transcriptome within the spectrum of changes that occur between undifferentiated hESCs and fetal heart cells. The hESC-CMs expressed cardiomyocyte genes at levels similar to those found in 20-week fetal heart cells, making this population a good source of potential replacement cells in vivo. Echocardiographic studies showed significant improvement in heart function by 8 weeks after transplantation. Finally, we demonstrate long-term engraftment of hESC-CMs by using molecular imaging to track cellular localization, survival, and proliferation in vivo. Taken together, global gene expression profiling of hESC differentiation enables a systems-based analysis of the biological processes, networks, and genes that drive hESC fate decisions, and studies such as this will serve as the foundation for future clinical applications of stem cell therapies.",
        "keywords": [
            "chemistry",
            "molecular imaging",
            "cell differentiation",
            "embryonic stem cells",
            "medicine",
            "engineering",
            "physics",
            "biological process",
            "gene expression profiling",
            "biology",
            "spectrum"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Roger A Wagner",
                "org": ""
            },
            {
                "name": "Kitchener D Wilson",
                "org": ""
            },
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Ji-Dong Fu",
                "org": ""
            },
            {
                "name": "Micha Drukker",
                "org": ""
            },
            {
                "name": "Andrew Lee",
                "org": ""
            },
            {
                "name": "Ronald A Li",
                "org": ""
            },
            {
                "name": "Sanjiv S Gambhir",
                "org": ""
            },
            {
                "name": "Irving L Weissman",
                "org": ""
            },
            {
                "name": "Robert C Robbins",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2008
    },
    "OnDsj6fJ": {
        "id": "OnDsj6fJ",
        "title": "Induced Pluripotent Stem Cells and Cardiovascular Disease",
        "abstract": "Several types of terminally differentiated somatic cells can be reprogrammed to the pluripotent state by ectopic expression of Klf4,Oct3/4,Sox2 and c-Myc.Such induced pluripotent stem cells(iPSCs) have the potential to serve as an autologous source of cells for tissue repair.However,there are still a series of problems with this technology that remain unsolved such as low productivity,increased risk of tumorigenesis,and the residual presence of integrated transgenes.This article reviews the latest progress on research involved in iPS cells cardiac differentiation,characteristic of iPSCs-derived cardiomyocytes and their applications in cardiovascular regenerative medicine.",
        "keywords": [
            "cardiac differentiation",
            "induced pluripotent stem cells-derived cardiomyocytes",
            "induced pluripotent stem cells",
            "regenerative medicine"
        ],
        "authors": [
            {
                "name": "LIU Tong",
                "org": "Department of Cardiology,Xijing Hospital,The Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": "Department of Cardiology,Xijing Hospital,The Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,The Fourth Military Medical University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Advances in Cardiovascular Diseases",
        "year": 2011
    },
    "f8gF4qTC": {
        "id": "f8gF4qTC",
        "title": "Trafficking the fate of mesenchymal stem cells in vivo",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hui wang",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "abhijit de",
                "org": ""
            },
            {
                "name": "sanjiv s gambhir",
                "org": ""
            },
            {
                "name": "joseph wu",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "Lpfn0Qri": {
        "id": "Lpfn0Qri",
        "title": "Can insulin resistance be reversed by insulin therapy?",
        "abstract": "Insulin resistance (IR) is a state of decreased tissue sensitivity to insulin, which commonly exists in patients with metabolic syndrome and diabetes, and leads to compensatory hyperinsulinemia to maintain normoglycemia. It is characterized by pathway-specific inhibition of the PI3K/Akt signaling, which concerns the positive actions of insulin including glucose and lipid metabolism, while other pathways including the Ras/MAPK pathway, which accounts for the negative actions of insulin such as stimulation of smooth muscle proliferation and secretion of endothelin-1, stay unaffected. Thus it was concerned that insulin therapy may exacerbate the negative effects of insulin in IR states. However, treatment of diabetes with insulin in clinical practice showed uniformly beneficial rather than harmful results. So we hypothesize that insulin therapy may itself reverse insulin resistance, thus avoiding magnification of the MAPK pathway-related deleterious effects. The mechanisms may include the recently revealed anti-inflammatory effects of insulin as well as its conventional glucose and free fatty acids lowering effects, and possibly may also include changes in body fat distribution and plasma adiponectin level. Whether there are direct mechanisms that insulin therapy modulates insulin sensitivity remains to be investigated.",
        "keywords": [],
        "authors": [
            {
                "name": "Li Zhao",
                "org": "Department of cardiovascular medicine, Xijing Hospital, the Fourth Military Medical University, 15 West Changle Road, 710032 Xi’an, Shaanxi, China"
            },
            {
                "name": "Dongdong Sun",
                "org": "Department of cardiovascular medicine, Xijing Hospital, the Fourth Military Medical University, 15 West Changle Road, 710032 Xi’an, Shaanxi, China"
            },
            {
                "name": "Feng Cao",
                "org": "Department of cardiovascular medicine, Xijing Hospital, the Fourth Military Medical University, 15 West Changle Road, 710032 Xi’an, Shaanxi, China"
            },
            {
                "name": "Tao Yin",
                "org": "Department of cardiovascular medicine, Xijing Hospital, the Fourth Military Medical University, 15 West Changle Road, 710032 Xi’an, Shaanxi, China"
            },
            {
                "name": "Haichang Wang",
                "org": "Corresponding author. Tel.: +86 29 84773469; fax: +86 29 84773469."
            }
        ],
        "venue": "Medical Hypotheses",
        "year": 2009
    },
    "iWuRzYfT": {
        "id": "iWuRzYfT",
        "title": "Effect of autologous bone marrow mononuclear cells transplantation in diabetic patients with ST-segment elevation myocardial infarction.",
        "abstract": "To investigate the efficacy and proposed mechanism of bone marrow mononuclear cells (BMMNCs) transplantation for diabetic and non-diabetic patients with ST-segment elevation myocardial infarction (STEMI).One hundred and sixteen patients with STEMI who had successfully undergone percutaneous coronary intervention (PCI) were divided into a diabetic group (n=51) and non-diabetic group (n=65). All of the patients received intracoronary injection of BMMNCs.Diabetes down-regulated IGF-1, IGFBP-5, VEGF, SDF-1, IL-6, IL-1α and TNF-α expression and affected the expression of Bmi-1, Gfi1, Tel and Hox-B4 which could prevent premature senescence and maintain the self-renewal capacity of stem cells. Event-free survival rates were not statistically different between the diabetic and non-diabetic group (80% vs. 72.5%, p=0.382). LV ejection fraction (LVEF) and wall motion score index (WMSI) were evaluated by echocardiography and found to be significantly improved in the non-diabetic group compared to the diabetic group over the 4-year follow-up period. Improved myocardial perfusion and reduced infarct size in the non-diabetic group compared to the diabetic group was verified using single-photon emission computed tomographic (SPECT) imaging. The non-diabetic group also had reduced anginal symptoms as assessed by changes in their Seattle Angina Questionnaire scores and Canadian Cardiovascular Society (CCS) Functional Angina classification. An improvement of 6-minute walk distance (6MWD) was also noted to be higher in the non-diabetic group during the follow-up period.This study indicates that the beneficial effect of BMMNCs transplantation for STEMI is less pronounced in diabetic patients. The mechanism is associated with decreased BMMNCs function in diabetic patients.",
        "keywords": [
            "Diabetes",
            "Bone marrow mononuclear cells",
            "ST-segment elevation myocardial infarction",
            "Percutaneous coronary intervention",
            "Left ventricular function"
        ],
        "authors": [
            {
                "name": "Dongdong Sun",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            },
            {
                "name": "kazim h narsinh",
                "org": "Department of Radiology, Stanford University School of Medicine, CA, USA"
            },
            {
                "name": "Haichang Wang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            },
            {
                "name": "Chengxiang Li",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            },
            {
                "name": "Weijie Li",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            },
            {
                "name": "Zheng Zhang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            },
            {
                "name": "Jiayi Li",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"
            }
        ],
        "venue": "International Journal of Cardiology",
        "year": 2013
    },
    "TpLlOD4V": {
        "id": "TpLlOD4V",
        "title": "Evaluation of fractional flow reserve in patients with stable angina: can CT compete with angiography?",
        "abstract": "We aimed to compare the performance of FFRCT and FFRQCA in assessing the functional significance of coronary artery stenosis in patients suffering from coronary artery disease with stable angina. A total of 101 stable coronary heart disease (CAD) patients with 181 lesions were recruited. FFRCT and FFRQCA were compared using invasive fractional flow reserve (FFR) as a reference standard. Comparisons between FFRCT and FFRQCA were conducted based on strategies of the geometric reconstruction, boundary conditions, and geometric characteristics. The performance of FFRCT and FFRQCA in detecting hemodynamic significance was also investigated. The performance of FFRCT and FFRQCA in discriminating hemodynamically significant lesions was compared. Good correlation and agreement with invasive FFR was found using FFRCT and FFRQCA (r = 0.809, p < 0.001 and r = 0.755, p < 0.001). A significant difference was observed in the complex coronary artery tree, in which relatively better prediction was observed using FFRCT than FFRQCA when analyzing the stenosis distributed in the middle segment of a stenotic branch (p = 0.036). Moreover, FFRCT was found to be better at predicting hemodynamically insignificant stenosis than FFRQCA (p = 0.007), while the performance of the two parameters was similar in discriminating functional significant lesions using an FFR threshold of ≤ 0.8 as a reference standard. FFRCT and FFRQCA could both accurately rule out functional insignificant lesions in stable CAD patients. FFRCT was found to be better for the noninvasive screening of CAD patients with stable angina than FFRQCA. \n                  • FFR\n                  \n                    CT\n                  \n                  and FFR\n                  \n                    QCA\n                  \n                  were both in good correlation and agreement with invasive FFR measurements.\n                 \n                  • FFR\n                  \n                    CT\n                  \n                  is superior in accuracy and consistency compared to FFR\n                  \n                    QCA\n                  \n                  in patients with stenoses distributed in left coronary artery.\n                 \n                  • The noninvasive nature of FFR\n                  \n                    CT\n                  \n                  could provide potential benefit for stable CAD patients on disease management.",
        "keywords": [
            "Myocardial fractional flow reserve",
            " Computed tomography angiography",
            " Coronary artery disease",
            " Hemodynamics",
            " Myocardial ischemia"
        ],
        "authors": [
            {
                "name": "Xin Liu",
                "org": "Shenzhen Institutes of Advanced Technology & National Clinical Research Center of Geriatric Disease, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Yabin Wang",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Heye Zhang",
                "org": "Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China"
            },
            {
                "name": "Youbing Yin",
                "org": "Shenzhen Keya Medical Technology, Shenzhen, China"
            },
            {
                "name": "Kunlin Cao",
                "org": "Shenzhen Keya Medical Technology, Shenzhen, China"
            },
            {
                "name": "Zhifan Gao",
                "org": "The School of Schulich Medicine and Dentistry, Western University, London, Canada"
            },
            {
                "name": "Huafeng Liu",
                "org": "State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "William Kongto Hau",
                "org": "Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Lei Gao",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Yundai Chen",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Cardiology & National Clinical Research Center of Geriatric Disease, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Wenhua Huang",
                "org": "School of Basic Medical Science, Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, Southern Medical University, Guangzhou, China"
            }
        ],
        "venue": "European Radiology",
        "year": 2019
    },
    "AlXPf1ML": {
        "id": "AlXPf1ML",
        "title": "Identification of angiogenesis and viable myocardium using hybrid cardiac imaging.",
        "abstract": "The existing hybrid cardiac imaging approaches focus on predicting the adverse cardiac events or disease diagnosis, yet do not offer any insight into the pathological advance in the repair process. Angiogenesis is one of the most important mechanism in the repair process after ischemic injury and has shown benefit to the prognosis of occlusive cardiovascular disorders, thus becomes a target of molecular therapies. In vivo monitoring of angiogenesis and comprehensive evaluation of cardiac function associated with angiogenesis are urgently needed in both research and clinical practice. In this paper, a multimodality image fusion strategy was proposed for angiogenesis and viable myocardium identification. Imaging approaches including coronary computed tomography angiography(CCTA), 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]DG) PET/CT, [68Ga]-1,4,7-triazacyclononane-1,4,7-triacetic acid-(Arg-Gly-Asp)2 ([Ga-68]-NOTA-PRGD2) PET/CT and Tc-99m-sestamibi (Tc-99m-MIBI) myocardial perfusion SPECT/CT scanning were performed to acquire both anatomy and three kinds of function information. All of these modality images were then fused by an automatic strategy consisting of ROI segmentation and cross modality registration. The left ventricle myocardium was categorized into 4 groups based on fusion result according to the respective relative tracer uptake. The final results intuitively reflected the extent of the [F-18]DG and Tc-99m-MIBI uptake defect, the perfusion-metabolism mismatch area, as well as the location of the [Ga-68]-NOTA-PRGD2 signal. The hybrid CCTA-PET-SPECT image verified the occurrence of angiogenesis based on the in vivo noninvasive molecular imaging approaches and visualized the hibernating myocardium. The presented fusion strategy is helpful in facilitating the study of the relationship between viability, perfusion and blocked coronary arteries, as well as angiogenesis.",
        "keywords": [
            "Hybrid cardiac imaging",
            "Angiogenesis",
            "Hibernating myocardium",
            "Image fusion"
        ],
        "authors": [
            {
                "name": "Zhenzhen Xu",
                "org": "Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China"
            },
            {
                "name": "Bo Tao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100089, Peoples R China"
            },
            {
                "name": "Shenghan Ren",
                "org": "Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100089, Peoples R China"
            },
            {
                "name": "Jimin Liang",
                "org": "Xidian Univ, Sch Life Sci & Technol, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2019
    },
    "NPnvcJpX": {
        "id": "NPnvcJpX",
        "title": "The synergistic effect of valsartan and LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] on vascular oxidative stress and inflammation in type 2 diabetic mice.",
        "abstract": "Aim. To investigate the combination effects and mechanisms of valsartan (angiotensin II type 1 receptor blocker) and LAF237 (DPP-IV inhibitor) on prevention against oxidative stress and inflammation injury in db/db mice aorta. Methods. Db/db mice (n = 40) were randomized to receive valsartan, LAF237, valsartan plus LAF237, or saline. Oxidative stress and inflammatory reaction in diabetic mice aorta were examined. Results. Valsartan or LAF237 pretreatment significantly increased plasma GLP-1 expression, reduced apoptosis of endothelial cells isolated from diabetic mice aorta. The expression of NAD(P)H oxidase subunits also significantly decreased resulting in decreased superoxide production and ICAM-1 (fold change: valsartan : 7.5 +/- 0.7, P < 0.05; LAF237: 10.2 +/- 1.7, P < 0.05), VCAM-1 (fold change: valsartan : 5.2 +/- 1.2, P < 0.05; LAF237: 4.8 +/- 0.6, P < 0.05), and MCP-1 (fold change: valsartan: 3.2 +/- 0.6, LAF237: 4.7 +/- 0.8; P < 0.05) expression. Moreover, the combination treatment with valsartan and LAF237 resulted in a more significant increase of GLP-1 expression. The decrease of the vascular oxidative stress and inflammation reaction was also higher than monotherapy with valsartan or LAF237. Conclusion. These data indicated that combination treatment with LAF237 and valsartan acts in a synergistic manner on vascular oxidative stress and inflammation in type 2 diabetic mice.",
        "keywords": [
            "apoptosis"
        ],
        "authors": [
            {
                "name": "Min Shen",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Dongdong Sun",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Weijie Li",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Bing Liu",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Shenxu Wang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Zheng Zhang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China"
            }
        ],
        "venue": "EXPERIMENTAL DIABETES RESEARCH",
        "year": 2012
    },
    "g8ylQkiF": {
        "id": "g8ylQkiF",
        "title": "18F-labeled bombesin analogs for targeting GRP receptor-expressing prostate cancer.",
        "abstract": "The gastrin-releasing peptide receptor (GRPR) is found to be overexpressed in a variety of human tumors. The aim of this study was to develop 18F-labeled bombesin analogs for PET of GRPR expression in prostate cancer xenograft models.[Lys3]Bombesin ([Lys3]BBN) and aminocaproic acid-bombesin(7-14) (Aca-BBN(7-14)) were labeled with 18F by coupling the Lys3 amino group and Aca amino group, respectively, with N-succinimidyl-4-18F-fluorobenzoate (18F-SFB) under slightly basic condition (pH 8.5). Receptor-binding affinity of FB-[Lys3]BBN and FB-Aca-BBN(7-14) was tested in PC-3 human prostate carcinoma cells. Internalization and efflux of both radiotracers were also evaluated. Tumor-targeting efficacy and in vivo kinetics of both radiotracers were examined in male athymic nude mice bearing subcutaneous PC-3 tumors by means of biodistribution and dynamic microPET imaging studies. 18F-FB-[Lys3]BBN was also tested for orthotopic PC-3 tumor delineation. Metabolic stability of 18F-FB-[Lys3]BBN was determined in mouse blood, urine, liver, kidney, and tumor homogenates at 1 h after injection.The typical decay-corrected radiochemical yield was about 30%-40% for both tracers, with a total reaction time of 150 +/- 20 min starting from 18F-. 18F-FB-[Lys3]BBN had moderate stability in the blood and PC-3 tumor, whereas it was degraded rapidly in the liver, kidneys, and urine. Both radiotracers exhibited rapid blood clearance. 18F-FB-[Lys3]BBN had predominant renal excretion. 18F-FB-Aca-BBN(7-14) exhibited both hepatobiliary and renal clearance. Dynamic microPET imaging studies revealed that the PC-3 tumor uptake of 18F-FB-[Lys3]BBN in PC-3 tumor was much higher than that of 18F-FB-Aca-BBN(7-14) at all time points examined (P < 0.01). The receptor specificity of 18F-FB-[Lys3]BBN in vivo was demonstrated by effective blocking of tumor uptake in the presence of [Tyr4]BBN. No obvious blockade was found in PC-3 tumor when 18F-FB-Aca-BBN(7-14) was used as radiotracer under the same condition. 18F-FB-[Lys3]BBN was also able to visualize orthotopic PC-3 tumor at early time points after tracer administration, at which time minimal urinary bladder activity was present to interfere with the receptor-mediated tumor uptake.This study demonstrates that 18F-FB-[Lys3]BBN and PET are suitable for detecting GRPR-positive prostate cancer in vivo.",
        "keywords": [
            "at which time minimal urinary bladder activity was present to interfere with the receptor-mediated tumor uptake. conclusion: this study demonstrates that 18f-fb- lys3bbn and pet are suitable for detecting grpr-positive pros- tate cancer in vivo. key words: prostate cancer",
            "18f-bombesin",
            "microct j nucl med 2006",
            "also able to visualize orthotopic pc-3 tumor at early time points after tracer administration",
            "micropet",
            "47:492-501",
            "grp receptor",
            "receptor binding",
            "kinetics",
            "reaction time"
        ],
        "authors": [
            {
                "name": "Xianzhong Zhang",
                "org": "Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, USA."
            },
            {
                "name": "Weibo Cai",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Eduard Schreibmann",
                "org": ""
            },
            {
                "name": "Yun Wu",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            },
            {
                "name": "Lei Xing",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Journal of nuclear medicine : official publication, Society of Nuclear Medicine",
        "year": 2006
    },
    "e5vg7trw": {
        "id": "e5vg7trw",
        "title": "Abstract 2713: Molecular Imaging of Cardiac Stem Cell Mediated Angiogenic Gene Therapy",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoyan xie",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "ahmad y sheikh",
                "org": ""
            },
            {
                "name": "zongjin li",
                "org": ""
            },
            {
                "name": "xuetao pei",
                "org": ""
            },
            {
                "name": "sanjiv s gambhir",
                "org": ""
            },
            {
                "name": "renke li",
                "org": ""
            },
            {
                "name": "robert c robbins",
                "org": ""
            },
            {
                "name": "joseph c wu",
                "org": ""
            }
        ],
        "venue": "Circulation",
        "year": 2006
    },
    "unAsMGGX": {
        "id": "unAsMGGX",
        "title": "Moderate dose insulin promotes function of endothelial progenitor cells.",
        "abstract": "EPCs (endothelial progenitor cells) regenerate the vascular endothelial cells and keep the integrity of the vascular endothelium and thus may retard the onset of atherosclerosis. Steady state levels of EPCs in the circulation were found to be correlated with cardiovascular event risks. Given the close relationship between insulin and the cardiovascular system, we tested the long-term effects of moderate-dose insulin treatment on bone marrow-derived EPCs. Rat bone marrow EPCs were exposed to various levels of insulin under normal (5 mmol/l) or high (40 mmol/l) glucose conditions for 7 days. Insulin at levels near the physiological range (0.1, 1 nmol/l) up-regulated EPCs proliferation, stimulated NO (nitric oxide) production and reduced EPC senescence and ROS (reactive oxygen species) generation under both normal- and high-glucose conditions. Glucose exerted deleterious effects on EPCs contrary to insulin. Western blot analysis suggested concomitant decrease of Akt phosphorylation and eNOS (endothelial nitric oxide synthase) expression by high-glucose treatment and increase with insulin administration. Thus, insulin promoted several activities of EPCs, which suggested a potential endothelial protective role of insulin. Akt/eNOS pathway may be involved in the modulation of EPCs function by glucose and insulin.",
        "keywords": [
            "endothelial progenitor cell (EPC)",
            "glucose",
            "insulin",
            "nitric oxide (NO)",
            "senescence"
        ],
        "authors": [
            {
                "name": "Li Zhao",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            },
            {
                "name": "Feng Cao",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            },
            {
                "name": "Tao Yin",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            },
            {
                "name": "Dongdong Sun",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            },
            {
                "name": "Kang Cheng",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            },
            {
                "name": "Jun Zhang",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            },
            {
                "name": "Haichang Wang",
                "org": "Fourth Mil Med Univ, Dept Cardiol, Xijing Hosp, Xian 710032, Peoples R China"
            }
        ],
        "venue": "CELL BIOLOGY INTERNATIONAL",
        "year": 2011
    },
    "afnqwRge": {
        "id": "afnqwRge",
        "title": "FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction.",
        "abstract": "The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which is cleaved from its precursor fibronectin type III domain-containing protein 5 (FNDC5), is believed to be involved in a cardioprotective effect, but little was known on injured BM-MSCs and MI repair yet. Here, we investigated whether FNDC5 or irisin could improve the low viability of transplanted BM-MSCs and increase their therapeutic efficacy after MI. BM-MSCs, isolated from dual-reporter firefly luciferase and enhanced green fluorescent protein positive (Fluc+–eGFP+) transgenic mice, were exposed to normoxic condition and hypoxic stress for 12 h, 24 h, and 48 h, respectively. In addition, BM-MSCs were treated with irisin (20 nmol/L) and overexpression of FNDC5 (FNDC5-OV) in serum deprivation (H/SD) injury. Furthermore, BM-MSCs were engrafted into infarcted hearts with or without FNDC5-OV. Hypoxic stress contributed to increased apoptosis, decreased cell viability, and paracrine effects of BM-MSCs while irisin or FNDC5-OV alleviated these injuries. Longitudinal in vivo bioluminescence imaging and immunofluorescence results illustrated that BM-MSCs with overexpression of FNDC5 treatment (FNDC5-MSCs) improved the survival of transplanted BM-MSCs, which ameliorated the increased apoptosis and decreased angiogenesis of BM-MSCs in vivo. Interestingly, FNDC5-OV elevated the secretion of exosomes in BM-MSCs. Furthermore, FNDC5-MSC therapy significantly reduced fibrosis and alleviated injured heart function. The present study indicated that irisin or FNDC5 improved BM-MSC engraftment and paracrine effects in infarcted hearts, which might provide a potential therapeutic target for MI.",
        "keywords": [
            "Bone marrow mesenchymal stem cells (BM-MSCs)",
            " Myocardial infarction (MI)",
            " Fibronectin type III domain-containing protein 5 (FNDC5)",
            " Irisin",
            " Apoptosis",
            " Cell viability"
        ],
        "authors": [
            {
                "name": "Jingyu Deng",
                "org": "Department of Cardiology, Postgraduate Training Base in PLA Rocket Force Characteristic Medical Center, Jinzhou Medical University, Jinzhou, China"
            },
            {
                "name": "Ning Zhang",
                "org": "Central Beijing Medical District, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Yong Wang",
                "org": "Department of Nuclear Medicine, the Fifth Medical Center,, Chinese PLA General Hospital (Former 307th Hospital of the PLA), Beijing, China"
            },
            {
                "name": "Chao Yang",
                "org": "Department of Cardiology, PLA Rocket Force Characteristic Medical Center, Beijing, China"
            },
            {
                "name": "Yabin Wang",
                "org": "National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Chao Xin",
                "org": "Department of Cardiology, PLA Rocket Force Characteristic Medical Center, Beijing, China"
            },
            {
                "name": "Jinming Zhao",
                "org": "Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China"
            },
            {
                "name": "Zhitao Jin",
                "org": "Department of Cardiology, PLA Rocket Force Characteristic Medical Center, Beijing, China"
            },
            {
                "name": "Feng Cao",
                "org": "National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese PLA General Hospital, Beijing, China"
            },
            {
                "name": "Zheng Zhang",
                "org": "Department of Cardiology, PLA Rocket Force Characteristic Medical Center, Beijing, China"
            }
        ],
        "venue": "Stem Cell Research & Therapy",
        "year": 2020
    },
    "MoZxU5Bj": {
        "id": "MoZxU5Bj",
        "title": "Alteration of Toll-like receptor 4 pathway expression in cardiac microvascular endothelial cells during hypoxia-reoxygenation injury",
        "abstract": "AIM: To detect the alteration of Toll-like receptor 4(TLR-4) pathway expression in cardiac microvascular endothelial cells(CMECs) during hypoxia-reoxygenation(H-R) injury.METHODS: CMECs isolated from the hearts of adult rats were exposed to hypoxia(94% N2,5% CO2,1% O2) for 6 h followed by 2,12 or 24 h reoxygenation(95% air,5% CO2).Proliferation of CMECs was assessed by MTT assay,TLR-4 and NF-κB expressions were analyzed by Western blot and levels of IL-6 and TNF-α were detected by ELISA kits.RESULTS: The proliferation ability of CMECs was significantly inhibited by H-R injury(P<0.01) and H-R injury increased the TLR-4 expression 2 and 12 h after reoxygenation(P<0.05).The level of NF-κB increased 2 and 24 h after reoxygenation(P<0.05) and H-R injury enhanced IL-6 and TNF-α secretion compared with those in control groups(P<0.05).CONCLUSION: H-R injury increases the TLR-4 and NF-κB expressions in CMECs and enhances secretion of IL-6 and TNF-α.Activation of TLR-4/NF-κB pathway may participate in H-R injury of CMECs.",
        "keywords": [
            "cardiac microvascular endothelial cells",
            "hypoxia-reoxygenation injury",
            "TLR-4"
        ],
        "authors": [
            {
                "name": "ZHANG Zheng",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Ya-bin",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "SUN Dong-dong",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHOU Xuan",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Hai-chang",
                "org": "Department of Cardiovascular Diseases,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2010
    },
    "dGDc2cRQ": {
        "id": "dGDc2cRQ",
        "title": "Culture and molecular imaging identification of adipose derived mesenchymal stem cells with stable reporter gene expression in vitro and in vivo",
        "abstract": "BACKGROUND:Previous studies show that molecular imaging can monitor the stem cell qualitatively and quantitatively at cellular and molecular levels in vivo and hold promise in long-time evaluation of the stem cell.OBJECTIVE:To construct adipose derived mesenchymal stem cells(ADMSCs) with stable reporter genes expression and identify it by reporter gene imaging in vitro and in vivo.METHODS:β-actin-luc transgenic mice were selected firstly.Then ADMSCs were cultured from β-actin-luc mice by modified collagenase method.ADMSCs at passage 3 were identified by flow cytometry.ADMSCs(1×106) were implanted into the muscles of hindlimb of BALB/c nude mice,then tracked and quantified by firefly luciferase(fluc) bioluminescence imaging(BLI) in vitro and in vivo.RESULTS AND CONCLUSION:The transgenic mice stably carried β-actin-luc reporter gene and the ADMSCs were positive for CD90 and CD44,while negative for CD45,CD34 and CD31.ADMSCs consistently expressed the fluc and a robust correlation existed between different cell numbers and fluc average radiance(r2=0.96).After 24-hours engrafted ADMSCs survived and displayed strong BLI signal,which increased rapidly and then decreased smoothly during 0-42 minutes after peritoneal injection of D-luciferin,the peak being(6.92×106±4.11×105) Photons·s-1·cm-2·sr-1 at 21 minutes.Results indicated that ADMSCs of β-actin-luc transgenic mice could highly express the markers of MSCs,stably carry the reporter gene and facilitate the tracking and quantifying by BLI in vitro and in vivo.",
        "keywords": [],
        "authors": [
            {
                "name": "Fan Wei-wei",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Wang Ya-bin",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Zhang Rong-qing",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Li Cong-ye",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Li Shuang",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China"
            },
            {
                "name": "Cao Feng",
                "org": " Department of Cardiology,Xijing Hospital,Fourth Military Medical University of Chinese PLA,Xi'an ,Shaanxi Province,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2011
    },
    "fNdfnBGh": {
        "id": "fNdfnBGh",
        "title": "Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes.",
        "abstract": "Apelin, a cytokine mainly secreted by adipocytes, is closely related with insulin resistance. The underlying molecular mechanisms of how apelin affects insulin resistance, however, are poorly understood. This study aimed to investigate the effect of apelin on glucose metabolism and insulin resistance in 3T3-L1 adipocytes. After 10 ng/ml TNF-α treatment for 24 h, insulin-stimulated glucose uptake was reduced by 47% in 3T3-L1 adipocytes. Apelin treatment improved glucose uptake in a time- and dose-dependent manner. Treatment of 1,000 nM apelin for 60 min maximally augmented glucose uptake in insulin-resistant 3T3-L1 adipocytes. Furthermore, apelin pre-incubation also increased adipocytes' insulin-stimulated glucose uptake, and PI3K/Akt pathway were involved in these effects. In addition, immunocytochemistry staining and western blotting analysis indicated that apelin could increase glucose transporter 4 translocation from the cytoplasm to the plasma membrane. Apelin also increased the anti-inflammatory adipokine adiponectin mRNA expression while reducing that of pro-inflammatory adipokine interleukin-6 in insulin-resistant 3T3-L1 adipocytes. These results suggest that apelin stimulates glucose uptake through the PI3K/Akt pathway, promotes GLUT4 translocation from the cytoplasm to the plasma membrane, and modulates inflammatory responses in insulin-resistant 3T3-L1 adipocytes.",
        "keywords": [
            "apelininsulin resistanceglucose uptake � aktglut4",
            "molecular mechanics",
            "glucose metabolism",
            "glucose transport"
        ],
        "authors": [
            {
                "name": "Shunming Zhu",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Fei Sun",
                "org": "Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Weijie Li",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Yanjie Cao",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Chen Wang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Yabin Wang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Dong Liang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Rongqing Zhang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Shenwei Zhang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Haichang Wang",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            },
            {
                "name": "Feng Cao",
                "org": "Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xian, 710032 Shaanxi, China"
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2011
    },
    "bH0uWA0g": {
        "id": "bH0uWA0g",
        "title": "e0009 Multimodality molecular imaging of adipose-derived mesenchymal stem cells with VEGF in hindlimb ischaemia mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "f weiwei",
                "org": ""
            },
            {
                "name": "cao feng",
                "org": ""
            },
            {
                "name": "wang yabin",
                "org": ""
            },
            {
                "name": "l junting",
                "org": "xidian university"
            },
            {
                "name": "li shuang",
                "org": ""
            },
            {
                "name": "zhang rongqing",
                "org": ""
            },
            {
                "name": "l congye",
                "org": ""
            },
            {
                "name": "li chengxiang",
                "org": ""
            },
            {
                "name": "tian jie",
                "org": "xidian university"
            }
        ],
        "venue": "Heart",
        "year": 2010
    },
    "Vo9p1Bor": {
        "id": "Vo9p1Bor",
        "title": "Low-frequency pulsed magnetic fields protect cardiomyocytes from hypoxia/reoxygenation injury by affecting the \"NO/ONOO-balance\"",
        "abstract": "AIM: To investigate the effect of low-frequency pulsed magnetic fields(LF-PMFs) on proliferation and apoptosis of neonatal cardiomyocytes after hypoxia/reoxygenation(H/R) injury and the mechanism of NO/ONOO-balance involved.METHODS: Cultured neonatal cardiomyocytes were randomized into three groups: control group,H/R group,and LF-PMFs+H/R group.Viability and apoptosis of cardiomyocytes were assessed by MTT and TUNEL and levels of superoxide anion and NO/ONOO-were tested by Superoxide Assay Kit and Griess Assay,respectively.RESULTS: LF-PMFs promoted proliferation and inhibited apoptosis of neonatal cardiomyocytes following H/R treatment.Pre-/pro-treatment with LF-PMFs significantly downregulated the level of superoxide anion and ONOO-and upregulated NO expression of cardiomyocytes in vitro.LF-PMFs with 15 Hz,4.5 mT yielded the most beneficial effect compared with magnetic fields at other levels.CONCLUSIONS: LF-PMFs exert protective effects on cardiomyocytes from H/R injury via balancing NO/ONOO-.",
        "keywords": [
            "cardiomyocyte",
            "Low-frequency pulsed magnetic fields",
            "NO/ONOO-balance",
            "hypoxia/reoxygenation"
        ],
        "authors": [
            {
                "name": "ZHANG Zheng-xun",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "YI Fu",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "FAN Wei-wei",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Rong-qing",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "WANG Dong-juan",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "LI Xiu-juan",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            },
            {
                "name": "CAO Feng",
                "org": "Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi' an ,Shaanxi,China"
            }
        ],
        "venue": "Chinese Heart Journal",
        "year": 2013
    },
    "ZueJ2ax1": {
        "id": "ZueJ2ax1",
        "title": "Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.",
        "abstract": "Numerous studies have demonstrated the potential use of stem cells for the repair and regeneration of injured tissues. However, tracking transplanted stem cell fate and function in vivo remains problematic. To address these issues, murine embryonic stem (ES) cells were stably transduced with self-inactivating lentiviral vectors carrying either a triple fusion (TF) or double fusion (DF) reporter gene construct. The TF consisted of monomeric red fluorescence protein (mrfp), firefly luciferase (Fluc), and herpes simplex virus truncated thymidine kinase (HSV-ttk) reporter genes. The DF consisted of enhanced green fluorescence protein (egfp) and Fluc reporter genes but lacked HSV-ttk. Stably transduced ES-TF or ES-DF cells were selected by fluorescence activated cell sorting based on either mrfp (TF) or egfp (DF) expression. Afterwards, cells were injected subcutaneously into the right (ES-TF cells) and left (ES-DF cells) shoulders of adult female nude mice. Cell survival was tracked noninvasively by bioluminescence and positron emission tomography imaging of Fluc and HSV-ttk reporter genes, respectively. Imaging signals progressively increased from day 2 to day 14, consistent with ES cell survival and proliferation in vivo. However, teratoma formation occurred in all nude mice after 5 weeks. Administration of ganciclovir (GCV), targeting the HSV-ttk gene, resulted in selective ablation of teratomas arising from the ES-TF cells but not ES-DF cells. These data demonstrate the novel use of multimodality imaging techniques to (1) monitor transplanted ES cell survival and proliferation in vivo and (2) assess the efficacy of suicide gene therapy as a backup safety measure against teratoma formation.",
        "keywords": [
            "embryonic stem cell",
            "molecular imaging"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Micha Drukker",
                "org": ""
            },
            {
                "name": "Shuan Lin",
                "org": ""
            },
            {
                "name": "Ahmad Y Sheikh",
                "org": ""
            },
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Zongjin Li",
                "org": ""
            },
            {
                "name": "Andrew J Connolly",
                "org": ""
            },
            {
                "name": "Irving L Weissman",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "Cloning and stem cells",
        "year": 2007
    },
    "fAFNL3V3": {
        "id": "fAFNL3V3",
        "title": "Genetic modification of embryonic stem cells with VEGF enhances cell survival and improves cardiac function.",
        "abstract": "Cardiac stem cell therapy remains hampered by acute donor cell death posttransplantation and the lack of reliable methods for tracking cell survival in vivo. We hypothesize that cells transfected with inducible vascular endothelial growth factor 165 (VEGF(165)) can improve their survival as monitored by novel molecular imaging techniques. Mouse embryonic stem (ES) cells were transfected with an inducible, bidirectional tetracycline (Bi-Tet) promoter driving VEGF(165) and renilla luciferase (Rluc). Addition of doxycycline induced Bi-Tet expression of VEGF(165) and Rluc significantly compared to baseline (p<0.05). Expression of VEGF(165) enhanced ES cell proliferation and inhibited apoptosis as determined by Annexin-V staining. For noninvasive imaging, ES cells were transduced with a double fusion (DF) reporter gene consisting of firefly luciferase and enhanced green fluorescence protein (Fluc-eGFP). There was a robust correlation between cell number and Fluc activity (R(2)=0.99). Analysis by immunostaining, histology, and RT-PCR confirmed that expression of Bi-Tet and DF systems did not affect ES cell self-renewal or pluripotency. ES cells were differentiated into beating embryoid bodies expressing cardiac markers such as troponin, Nkx2.5, and beta-MHC. Afterward, 5 x 10(5) cells obtained from these beating embryoid bodies or saline were injected into the myocardium of SV129 mice (n=36) following ligation of the left anterior descending (LAD) artery. Bioluminescence imaging (BLI) and echocardiography showed that VEGF(165) induction led to significant improvements in both transplanted cell survival and cardiac function (p<0.05). This is the first study to demonstrate imaging of embryonic stem cell-mediated gene therapy targeting cardiovascular disease. With further validation, this platform may have broad applications for current basic research and further clinical studies.",
        "keywords": [
            "embryonic stem cell",
            "embryonic stem cells",
            "cardiac function",
            "apoptosis",
            "vascular endothelial growth factor a",
            "genetic modification",
            "cell proliferation",
            "heart"
        ],
        "authors": [
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Ahmad Y Sheikh",
                "org": ""
            },
            {
                "name": "Zongjin Li",
                "org": ""
            },
            {
                "name": "Andrew J Connolly",
                "org": ""
            },
            {
                "name": "Xuetao Pei",
                "org": ""
            },
            {
                "name": "Ren-Ke Li",
                "org": ""
            },
            {
                "name": "Robert C Robbins",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "Cloning and stem cells",
        "year": 2007
    },
    "RSBTPrC8": {
        "id": "RSBTPrC8",
        "title": "Adipose stromal cells amplify angiogenic signaling via the VEGF/mTOR/Akt pathway in a murine hindlimb ischemia model: a 3D multimodality imaging study.",
        "abstract": "Although adipose-derived stromal cell (ADSC) transplantation has been demonstrated as a promising therapeutic strategy for peripheral arterial disease (PAD), the mechanism of action behind the observed therapeutic efficacy of ADSCs remains unclear. This study was designed to investigate the long-term outcome and therapeutic behavior of engrafted ADSCs in a murine hindlimb ischemia model using multimodality molecular imaging approaches. ADSCs (1.0×10(7)) were isolated from Tg(Fluc-egfp) mice which constitutively express dual-reporter firefly luciferase and enhanced green fluorescent protein (Fluc(+)-eGFP(+), mADSCs(Fluc+GFP+)), then intramuscularly injected into the hindlimb of BALB/c-nu mice after unilateral femoral artery ligation and excision. Abbreviated survival (∼5 weeks) of post-transplant mADSCs within the ischemic hindlimb was longitudinally monitored using noninvasive bioluminescence imaging (BLI), fluorescence imaging (FRI), and bioluminescence tomography with micro-computed tomography (BLT/micro-CT). Use of the BLT/micro-CT system enabled quantitative 3-dimensional (3D) imaging of the cells' distribution and kinetics in vivo. Engrafted mADSCs improved blood perfusion recovery, ambulatory performance and prognosis of the ischemic hindlimb, probably by inducing angiogenesis and formation of collateral vessels, which could be visualized using laser Doppler perfusion imaging (LDPI), micro-CT angiography, vascular-cast imaging, and immunofluorescence. mADSCs augmented activation of the pro-angiogenic VEGF/mTOR/Akt pathway in vivo, even though the cells failed to incorporate into the host microvasculature as functional components. Downregulation of VEGF/mTOR/Akt signaling using small molecule inhibitors counteracted mADSC-induced angiogenesis and perfusion restoration. This study demonstrates for the first time the spatiotemporal kinetics and functional survival of transplanted mADSCs in a PAD model using in vivo 3D multimodality imaging. Our study indicates that mADSCs potentiate pro-angiogenic signal amplification via a VEGF/mTOR/Akt-dependent pathway, and thereby promote recovery from hindlimb ischemia.",
        "keywords": [
            "biology",
            "ischemia",
            "engineering",
            "hindlimb",
            "adipose tissue",
            "stromal cells",
            "physics",
            "chemistry",
            "medicine",
            "signal transduction",
            "vascular endothelial growth factor a"
        ],
        "authors": [
            {
                "name": "Weiwei Fan",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Dongdong Sun",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Junting Liu",
                "org": "Xidian University(Xidian University,Xidian Univ.),Xi An,China"
            },
            {
                "name": "Dong Liang",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Yabin Wang",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Kazim H Narsinh",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "Yong Li",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Xing Qin",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Jimin Liang",
                "org": "Xidian University(Xidian University,Xidian Univ.),Xi An,China"
            },
            {
                "name": "Jie Tian",
                "org": "Xidian University(Xidian University,Xidian Univ.),Xi An,China"
            },
            {
                "name": "Feng Cao",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            }
        ],
        "venue": "PloS one",
        "year": 2012
    },
    "28A2szNA": {
        "id": "28A2szNA",
        "title": "Novel radiomics features from CCTA images for the functional evaluation of significant ischaemic lesions based on the coronary fractional flow reserve score.",
        "abstract": "To explore the superiority of radiomics analysis in the diagnostic performance of coronary computed tomography angiography (CCTA) for identifying myocardial ischaemia and predicting major adverse cardiovascular events (MACE). A total of 105 lesions from 88 patients who underwent CCTA and invasive fractional flow reserve measurement were collected as the training set, and another 31 patients with CCTA and clinical outcome information were used as the validation set. Conventional CCTA features included the stenosis diameter, length, Agatston score and high-risk plaque characteristics. After extracting and selecting radiomics features, the robustness of the radiomics features was examined, and then conventional and radiomics models were established using logistic regressions. The area under the receiver operating characteristic (ROC) curve (AUC) and Net Reclassification Index (NRI) were analysed to compare the discrimination and classification abilities between the two models in both the training and validation sets. A total of 1409 radiomics features were extracted, and three wavelet features were finally screened out. The robustness test showed good stability for the refined radiomics features. Compared with the conventional model, the radiomics model displayed a significantly improved diagnostic performance in the training set (AUC 0.762 vs. 0.631, 95% confidence interval [CI] 0.671-0.853 vs. 0.519-0.742, P = 0.058) but a slightly improved diagnostic performance in the validation set (AUC 0.671 vs. 0.592, 95% CI 0.466-0.875 vs. 0.519-0.742, P = 0.448). The NRI of the radiomics model was increased in both the training and validation sets (NRI 0.198 and 0.238, respectively). Quantitative radiomics analysis was feasible and might help to improve the diagnostic performance of CCTA but is still controversial for predicting MACE.",
        "keywords": [
            "CT angiography",
            "Coronary artery disease",
            "Myocardial ischaemia",
            "Radiomics"
        ],
        "authors": [
            {
                "name": "Wenchao Hu",
                "org": "Medical School of Chinese PLA & Department of Cardiology, Chinese PLA General Hospital, Beijing, China."
            },
            {
                "name": "Xiangjun Wu",
                "org": "CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China."
            },
            {
                "name": "Di Dong",
                "org": "CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China."
            },
            {
                "name": "Long-Biao Cui",
                "org": "Department of Clinical Psychology, School of Medical Psychology, PLA Air Force Medical University, Xi'an, China."
            },
            {
                "name": "Min Jiang",
                "org": "Medical School of Chinese PLA & Department of Cardiology, Chinese PLA General Hospital, Beijing, China."
            },
            {
                "name": "Jibin Zhang",
                "org": "Medical School of Chinese PLA & Department of Cardiology, Chinese PLA General Hospital, Beijing, China."
            },
            {
                "name": "Yabin Wang",
                "org": "Department of Cardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, China."
            },
            {
                "name": "Xinjiang Wang",
                "org": "Second Medical Center & National Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing, China."
            },
            {
                "name": "Lei Gao",
                "org": "Second Medical Center & National Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing, China."
            },
            {
                "name": "Jie Tian",
                "org": "Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, China. jie.tian@ia.ac.cn."
            },
            {
                "name": "Feng Cao",
                "org": "Second Medical Center & National Research Center for Geriatric Disease, Chinese PLA General Hospital, Beijing, China. fengcao8828@163.com."
            }
        ],
        "venue": "The international journal of cardiovascular imaging",
        "year": 2020
    },
    "bTlYbvuw": {
        "id": "bTlYbvuw",
        "title": "Spatial and temporal kinetics of teratoma formation from murine embryonic stem cell transplantation.",
        "abstract": "Pluripotent embryonic stem (ES) cells have the potential to form teratomas composed of derivatives from all three germ layers in animal models. This tumorigenic potential prevents clinical translation of ES cell research. In order to understand the biology and physiology of teratoma formation, we investigated the influence of undifferentiated ES cell number, migration, and long-term follow up after transplantation. Murine ES cells were stably transduced with a self-inactivating (SIN) lentiviral vector with a constitutive ubiquitin promoter driving a double-fusion (DF) reporter gene that consists of firefly luciferase and enhanced green fluorescent protein (Fluc-eGFP). To assess effects of cell numbers, varying numbers of ES-DF cells (1, 10, 100, 1,000, and 10,000) were injected subcutaneously into the dorsal regions of adult nude mice. To assess cell migration, 1 x 10(6) ES-DF cells were injected intramyocardially into adult Sv129 mice, and leakage to other extracardiac sites was monitored. To assess effects of long-term engraftment, 1 x 10(4) ES-DF cells were injected intramyocardially into adult nude rats, and cell survival response was monitored for 10 months. Our results show that ES-DF cells caused extracardiac teratoma in both immunocompetent and immunodeficient hosts; the lowest number of undifferentiated ES cells capable of causing teratoma was 500-1,000; and long-term engraftment could be shown for >300 days. Collectively, these results illustrate the potent tumorigenic potential of ES cells, which presents an enormous obstacle for future clinical studies.",
        "keywords": [
            "embryonic stem cell",
            "kinetics"
        ],
        "authors": [
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Koen E A van der Bogt",
                "org": ""
            },
            {
                "name": "Amir Sadrzadeh",
                "org": ""
            },
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Ahmad Y Sheikh",
                "org": ""
            },
            {
                "name": "Haichang Wang",
                "org": ""
            },
            {
                "name": "Andrew J Connolly",
                "org": ""
            },
            {
                "name": "Robert C Robbins",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "Stem cells and development",
        "year": 2007
    },
    "4DZ3ZRNL": {
        "id": "4DZ3ZRNL",
        "title": "Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects.",
        "abstract": "Human embryonic stem (hES) cells are pluripotent stem cells capable of self-renewal and differentiation into virtually all cell types. Thus, they hold tremendous potential as cell sources for regenerative therapies. The concurrent development of accurate, sensitive, and noninvasive technologies capable of monitoring hES cells engraftment in vivo can greatly expedite basic research prior to future clinical translation. In this study, hES cells were stably transduced with a lentiviral vector carrying a novel double-fusion reporter gene that consists of firefly luciferase and enhanced green fluorescence protein. Reporter gene expression had no adverse effects on cell viability, proliferation, or differentiation to endothelial cells (human embryonic stem cell-derived endothelial cells [hESC-ECs]). To compare the two popular imaging modalities, hES cells and hESC-ECs were then colabeled with superparamagnetic iron oxide particles before transplantation into murine hind limbs. Longitudinal magnetic resonance (MR) imaging showed persistent MR signals in both cell populations that lasted up to 4 weeks. By contrast, bioluminescence imaging indicated divergent signal patterns for hES cells and hESC-ECs. In particular, hESC-ECs showed significant bioluminescence signals at day 2, which decreased progressively over the following 4 weeks, whereas bioluminescence signals from undifferentiated hES cells increased dramatically during the same period. Post-mortem histology and immunohistochemistry confirmed teratoma formation after injection of undifferentiated hES cells but not hESC-ECs. From these data taken together, we concluded that reporter gene is a better marker for monitoring cell viability, whereas iron particle labeling is a better marker for high-resolution detection of cell location by MR. Furthermore, transplantation of predifferentiated rather than undifferentiated hES cells would be more suited for avoiding teratoma formation.",
        "keywords": [
            "bioluminescence imaging",
            "cell line",
            "embryonic stem cells",
            "endothelial cell",
            "reporter gene",
            "magnetic resonance spectroscopy",
            "cell differentiation",
            "iron",
            "human embryonic stem cells",
            "differentiation",
            "particle size",
            "magnetic resonance imaging"
        ],
        "authors": [
            {
                "name": "Zongjin Li",
                "org": ""
            },
            {
                "name": "Yoriyasu Suzuki",
                "org": ""
            },
            {
                "name": "Mei Huang",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
                "name": "Andrew J Connolly",
                "org": ""
            },
            {
                "name": "Phillip C Yang",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "Stem cells (Dayton, Ohio)",
        "year": 2008
    },
    "KXvAKuFr": {
        "id": "KXvAKuFr",
        "title": "Rosuvastatin Prevents Adipose-derived Mesenchymal Stem Cells from Hypoxia/Reoxygenation Injury through Activation of ERK and AKT",
        "abstract": "Objective: To investigate the effects of Rosuvastatin on the proliferation of adipose-derived mesenchymal stem cells (AD-MSCs)after hypoxia/reoxygenation (H/R) injury. Methods: AD-MSCs were isolated from Kunming mice and characterized by flowcytometry. AD-MSCs were divided into three groups: (1) control,(2) Hypoxia 6hrs+ Reoxygen 42hrs (H/R), (3) H/R+Rosuvastatin (10-8,10-7,10-6mol/L respectively). Cell proliferation was detected by MTT assays. The protein expressions of Akt, Akt, Erk and pErk were analyzed by Western blot assay. Results: The CD44 and CD90 of AD-MSCs were positive. Administration of Rosuvastatin in- creased proliferation of AD-MSCs after H/R injury (P<0.05). Western blot assay revealed that the levels of phosphorylated Akt and phos- phorylated Erk were higher in Rosuvastatin group than that in H/R group. Conclusion: Rosuvastatin promoted the proliferation of AD-MSCs after H/R injury by AKT and ERK.",
        "keywords": [
            "Rosuvastatin",
            "Adipose-derived mesenchymal stem cells",
            "Hypoxia/reoxygenation injury",
            "Erk",
            "Akt"
        ],
        "authors": [
            {
                "name": "LI Shuang",
                "org": " Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi , China"
            },
            {
                "name": "WU Hao",
                "org": " Department of Toxicology, Fourth Military Medical University, Xi'an, Shanxi , China"
            },
            {
                "name": "ZHANG Rong-qing",
                "org": " Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi , China"
            },
            {
                "name": "LI Cong-ye",
                "org": " Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi , China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi , China"
            },
            {
                "name": "CAO Feng",
                "org": " Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi , China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2011
    },
    "eAx19WSZ": {
        "id": "eAx19WSZ",
        "title": "Activation of Melatonin Receptor 2 But Not Melatonin Receptor 1 Mediates Melatonin-conferred Cardio-protection Against Myocardial Ischemia/Reperfusion Injury.",
        "abstract": "Accumulated pieces of evidence have proved the beneficial effects of melatonin on myocardial ischemia/reperfusion (MI/R) injury, and these effects were largely dependent on melatonin membrane receptor activation. In humans and other mammals, there are two types of melatonin receptors, including the melatonin receptor 1 (MT1, melatonin receptor 1a or MTNR1A) and melatonin receptor 1 (MT2, melatonin receptor 1b or MTNR1B) receptor subtypes. However, which receptor mediates melatonin-conferred cardioprotection remains unclear. In this study, we employed both loss-of-function and gain-of-function approaches to reveal the answer. Mice (wild-type; MT1 or MT2 silencing by in vivo minicircle vector; and those overexpressing MT1 or MT2 by in vivo AAV9 vector) were exposed to MI/R injury. Both MT1 and MT2 were present in wild-type myocardium. MT2, but not MT1, was essentially upregulated after MI/R Melatonin administration significantly reduced myocardial injury and improved cardiac function after MI/R Mechanistically, melatonin treatment suppressed MI/R-initiated myocardial oxidative stress and nitrative stress, alleviated endoplasmic reticulum stress and mitochondrial injury, and inhibited myocardial apoptosis. These beneficial actions of melatonin were absent in MT2-silenced heart, but not the MT1 subtype. Furthermore, AAV9-mediated cardiomyocyte-specific overexpression of MT2, but not MT1, mitigated MI/R injury and improved cardiac dysfunction, which was accompanied by significant amelioration of oxidative stress, endoplasmic reticulum stress, and mitochondrial dysfunction. Mechanistically, MT2 protected primary cardiomyocytes against hypoxia/reoxygenation injury via MT2/Notch1/Hes1/ROR alpha signaling. Our study presents the first direct evidence that the MT2 subtype, but not MT1, is a novel endogenous cardiac protective receptor against MI/R injury. Medications specifically targeting MT2 may hold promise in fighting ischemic heart disease.",
        "keywords": [
            "apoptosis",
            "melatonin",
            "myocardium",
            "oxidative stress",
            "reperfusion injury"
        ],
        "authors": [
            {
                "name": "Dong Han",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Yongjun Wang",
                "org": "Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan, Hubei, Peoples R China"
            },
            {
                "name": "Jiangwei Chen",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Jibin Zhang",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian, Shaanxi, Peoples R China"
            },
            {
                "name": "Peng Yu",
                "org": "Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian, Shaanxi, Peoples R China"
            },
            {
                "name": "Ran Zhang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Shuang Li",
                "org": "Chengdu Mil Gen Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China"
            },
            {
                "name": "Bo Tao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Yabin Wang",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Ya Qiu",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Mengqi Xu",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            },
            {
                "name": "Erhe Gao",
                "org": "Temple Univ, Sch Med, Ctr Translat Med, Philadelphia, PA 19122 USA"
            },
            {
                "name": "Feng Cao",
                "org": "Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Dept Cardiol, Beijing, Peoples R China"
            }
        ],
        "venue": "JOURNAL OF PINEAL RESEARCH",
        "year": 2019
    },
    "JJ4fN4zA": {
        "id": "JJ4fN4zA",
        "title": "Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging.",
        "abstract": "Tracking stem cell localization, survival, differentiation, and proliferation after transplantation in living subjects is essential for understanding stem cell biology and physiology. In this study, we investigated the long-term stability of reporter gene expression in an embryonic rat cardiomyoblast cell line and the role of epigenetic modulation on reversing reporter gene silencing. Cells were stably transfected with plasmids carrying cytomegalovirus promoter driving firefly luciferase reporter gene (CMV-Fluc) and passaged repeatedly for 3-8 months. Within the highest expressor clone, the firefly luciferase activity decreased progressively from passage 1 ( 843 +/- 28) to passage 20 ( 250 +/- 10) to passage 40 ( 44 +/- 3) to passage 60 ( 3 +/- 1 RLU/mu g; P < 0.05 vs. passage 1). Firefly luciferase activity was maximally rescued by treatment with 5-azacytidine ( DNA methyltransferase inhibitor) compared with trichostatin A ( histone deacetylase inhibitor) and retinoic acid ( transcriptional activator; P < 0.05). Increasing dosages of 5-azacytidine treatment led to higher levels of firefly luciferase mRNA ( RT-PCR) and protein ( Western blots) and inversely lower levels of methylation in the CMV promoter ( DNA nucleotide sequence). These in vitro results were extended to in vivo bioluminescence imaging (BLI) of cell transplant in living animals. Cells treated with 5-azacytidine were monitored for 2 wk compared with 1 wk for untreated cells ( P < 0.05). These findings should have important implications for reporter gene-based imaging of stem cell transplantation.",
        "keywords": [
            "gene silencing",
            "molecular imaging",
            "stem cell transplant"
        ],
        "authors": [
            {
                "name": "Manickam Krishnan",
                "org": ""
            },
            {
                "name": "Jinha M Park",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Dongxu Wang",
                "org": ""
            },
            {
                "name": "Ramasay Paulmurugan",
                "org": ""
            },
            {
                "name": "Jeffrey R Tseng",
                "org": ""
            },
            {
                "name": "Mark L Gonzalgo",
                "org": ""
            },
            {
                "name": "Sanjiv S Gambhir",
                "org": ""
            },
            {
                "name": "Joseph C Wu",
                "org": ""
            }
        ],
        "venue": "FASEB JOURNAL",
        "year": 2005
    },
    "Jwf7JA8S": {
        "id": "Jwf7JA8S",
        "title": "Molecular imaging of p53 signal pathway in lung cancer cell cycle arrest induced by cisplatin.",
        "abstract": "Cisplatin is a commonly employed chemotherapy drug for lung malignancy. However its efficacy is limited by acquired drug resistance and lacking of an in vivo real-time monitoring approach. The aim of this study is to investigate the effect of cisplatin on lung adenocarcinoma cell line p53-RE-Fluc/A549 in vivo via non-invasive reporter gene by molecular imaging. For this study, we employed p53-RE-Fluc/A549 cells that overexpressed a vector with three tandem repeats of p53 response element followed by the luciferase reporter gene. P53 activity was evaluated by optical imaging and verified by Western blot after cells were exposed to 10 µM cisplatin for 72 h. The cell cycle was mainly blocked at the S- and G2/M-phases after cisplatin treatment, whereas no significant change was observed in cell apoptotic index. Increased expression of p21 and Bcl-2 as well as decreased expression of Bax were observed after cisplatin treatment by Western blotting. Longitudinal in vivo bioluminescent imaging (BLI) revealed that the p53 activity was increased from 24 to 48 h after transient cisplatin treatment in p53-RE-Fluc/A549-bearing nude mice. RNA sequencing further revealed that cell cycle and p53 signaling pathway genes, such as E2F1, CCNA2, CDK1, and CCNE2 were significantly downregulated after long-term cisplatin treatment. Thus, our study showed that cisplatin exerts its cytotoxic effect through blockage of the cell cycle and may be partly regulated by the p53 signaling pathway. Furthermore, molecular imaging is a useful tool to investigate the mechanism and evaluate the effect of chemotherapy drugs both in vivo and in vitro.",
        "keywords": [
            "lung cancer",
            "p53",
            "cisplatin",
            "molecular imaging",
            "cell cycle"
        ],
        "authors": [
            {
                "name": "Shenxu Wang",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Weijie Li",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Zengfu Xue",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Yuanyuan Lu",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Kazim Narsinh",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "Weiwei Fan",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Xiujuan Li",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Qingting Bu",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Fu Wang",
                "org": "Xidian University(Xidian University,Xidian Univ.),Xi An,China"
            },
            {
                "name": "Jimin Liang",
                "org": "Xidian University(Xidian University,Xidian Univ.),Xi An,China"
            },
            {
                "name": "Kaichun Wu",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            },
            {
                "name": "Feng Cao",
                "org": "Xijing Hospital(Fourth Military Medical University,Xijing Hospital),Xi'an,China"
            }
        ],
        "venue": "Molecular carcinogenesis",
        "year": 2013
    },
    "g1kYQUrA": {
        "id": "g1kYQUrA",
        "title": "Double-fusion human embryonic stem cells, methods of making double-fusion human embryonic stem cells, triple-fusion human embryonic stem cells, methods of making triple-fusion human embryonic stem cells, and methods of monitoring double-fusion human embryonic stem cells and triple-fusion human embryonic stem cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "joseph c wu",
                "org": ""
            },
            {
                "name": "feng cao",
                "org": ""
            },
            {
                "name": "sanjiv s gambhir",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "xBWqeXIL": {
        "id": "xBWqeXIL",
        "title": "In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation.",
        "abstract": "Embryonic stem cell (ESC)-based transplantation is considered a promising novel therapy for a variety of diseases. This is bolstered by the suggested immune-privileged properties of ESCs. In this study, we used in vivo bioluminescent imaging (BLI) to non-invasively track the fate of transplanted murine ESCs (mESCs), which are stably transduced with a double fusion reporter gene consisting of firefly luciferase (FLuc) and enhanced green fluorescent protein (eGFP). Following syngeneic intramuscular transplantation of 1 x 10(6) mESCs, the cells survived and differentiated into teratomas. In contrast, allogeneic mESC transplants were infiltrated by a variety of inflammatory cells, leading to rejection within 28 days. Acceleration of rejection was observed when mESCs were allotransplanted following prior sensitization of the host. Finally, we demonstrate that the mESC derivatives were more rapidly rejected compared to undifferentiated mESCs. These data show that mESCs do not retain immune-privileged properties in vivo and are subject to immunological rejection as assessed by novel molecular imaging approaches.",
        "keywords": [
            "in vivo imaging",
            "embryonic stem cells",
            "diagnostic imaging",
            "embryonic stem cell"
        ],
        "authors": [
            {
                "name": "Rutger-Jan Swijnenburg",
                "org": ""
            },
            {
                "name": "Sonja Schrepfer",
                "org": ""
            },
            {
                "name": "Feng Cao",
                "org": ""
            },
            {
                "name": "Jeremy I Pearl",
                "org": ""
            },
            {
                "name": "Xiaoyan Xie",
                "org": ""
            },
            {
            